KR20220081631A - 염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도 - Google Patents

염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도 Download PDF

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Publication number
KR20220081631A
KR20220081631A KR1020200171340A KR20200171340A KR20220081631A KR 20220081631 A KR20220081631 A KR 20220081631A KR 1020200171340 A KR1020200171340 A KR 1020200171340A KR 20200171340 A KR20200171340 A KR 20200171340A KR 20220081631 A KR20220081631 A KR 20220081631A
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South Korea
Prior art keywords
compound
disease
inflammatory
pharmaceutically acceptable
isomer
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Pending
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KR1020200171340A
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English (en)
Korean (ko)
Inventor
김수찬
김대권
서동혁
김현경
김성환
황혜민
최지은
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보로노이 주식회사
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Priority to KR1020200171340A priority Critical patent/KR20220081631A/ko
Priority to CN202180093340.1A priority patent/CN116916929A/zh
Priority to JP2023535390A priority patent/JP2023553944A/ja
Priority to TW110146107A priority patent/TW202239403A/zh
Priority to EP21902773.7A priority patent/EP4259153A4/en
Priority to US17/643,554 priority patent/US20220257605A1/en
Priority to PCT/IB2021/000857 priority patent/WO2022123311A1/en
Publication of KR20220081631A publication Critical patent/KR20220081631A/ko
Priority to US18/486,783 priority patent/US12194048B2/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020200171340A 2020-12-09 2020-12-09 염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도 Pending KR20220081631A (ko)

Priority Applications (8)

Application Number Priority Date Filing Date Title
KR1020200171340A KR20220081631A (ko) 2020-12-09 2020-12-09 염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도
CN202180093340.1A CN116916929A (zh) 2020-12-09 2021-12-09 吡咯并吡啶衍生物用于预防或治疗发炎疾病的新颖用途
JP2023535390A JP2023553944A (ja) 2020-12-09 2021-12-09 炎症性疾患を予防または処置するためのピロロピリジン誘導体の新規な使用
TW110146107A TW202239403A (zh) 2020-12-09 2021-12-09 吡咯并吡啶衍生物用於預防或治療發炎疾病之新穎用途
EP21902773.7A EP4259153A4 (en) 2020-12-09 2021-12-09 NEW USE OF PYRROLOPYRIDINE DERIVATIVES FOR THE PREVENTION OR TREATMENT OF INFLAMMATORY DISEASES
US17/643,554 US20220257605A1 (en) 2020-12-09 2021-12-09 Novel use of pyrrolopyridine derivatives for preventing or treating inflammatory diseases
PCT/IB2021/000857 WO2022123311A1 (en) 2020-12-09 2021-12-09 Novel use of pyrrolopyridine derivatives for preventing or treating inflammatory diseases
US18/486,783 US12194048B2 (en) 2020-12-09 2023-10-13 Use of pyrrolopyridine derivatives for preventing or treating inflammatory diseases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020200171340A KR20220081631A (ko) 2020-12-09 2020-12-09 염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도

Publications (1)

Publication Number Publication Date
KR20220081631A true KR20220081631A (ko) 2022-06-16

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KR1020200171340A Pending KR20220081631A (ko) 2020-12-09 2020-12-09 염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도

Country Status (7)

Country Link
US (2) US20220257605A1 (https=)
EP (1) EP4259153A4 (https=)
JP (1) JP2023553944A (https=)
KR (1) KR20220081631A (https=)
CN (1) CN116916929A (https=)
TW (1) TW202239403A (https=)
WO (1) WO2022123311A1 (https=)

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WO2023220396A1 (en) * 2022-05-13 2023-11-16 Fresh Tracks Therapeutics, Inc. Methods of treatment using a dual specificity tyrosine-phosphorylation-regulated kinase 1a (dyrk1a) inhibitor
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CN120754103B (zh) * 2025-09-09 2025-11-28 苏州大学 阿巴卡韦在制备类风湿性关节炎治疗药物中的应用

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KR20220081631A (ko) 2020-12-09 2022-06-16 보로노이 주식회사 염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도

Also Published As

Publication number Publication date
US20220257605A1 (en) 2022-08-18
JP2023553944A (ja) 2023-12-26
EP4259153A4 (en) 2024-10-09
US12194048B2 (en) 2025-01-14
EP4259153A1 (en) 2023-10-18
TW202239403A (zh) 2022-10-16
WO2022123311A1 (en) 2022-06-16
US20240180918A1 (en) 2024-06-06
CN116916929A (zh) 2023-10-20

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