KR20220051721A - Medi-food composition for induce deep sleep - Google Patents

Abstract

The present invention relates to medi-food composition for inducing a sound sleep. According to the present invention, the medi-food composition for inducing a sound sleep includes a Heukharang lettuce extract, and at least one of a valerian extract and an herbal extract, wherein the herbal extract is an extract containing at least one of lavender, chamomile, peppermint and rosemary. The medi-food composition for inducing a sound sleep according to an embodiment of the present invention can shorten a time to fall asleep by utilizing the Heukharang lettuce extract, and greatly improve the quality of sleep by allowing a user to sleep without waking up at night.

Description

Medi-food composition for induce deep sleep

The present invention relates to a medi-food composition for inducing deep sleep, and more particularly, by using black harang lettuce extract to shorten the waking time and to take a deep sleep without waking up at night, which can greatly improve the quality of sleep. It relates to a medi-food composition for inducing deep sleep.

Sleep can be defined in many ways, but it is mainly defined as a state of motion in which the ability to perceive and respond to the external environment is reversible, repetitive, and normally stationary. Sleep is driven by brain activity, but it is also deeply related to physiological changes in other parts of the body.

Sleep disturbance is a very common disease that has been experienced or suffered by more than 20% of the population. Sleep disturbance can cause a variety of personal and social problems and cause learning disabilities, decreased efficiency, traffic accidents, safety accidents, emotional disorders, social adjustment disorders, dissatisfaction with marriage, and industrial accidents. In addition, if sleep disorders are not properly treated, medical, neurological, and psychiatric diseases already suffered may worsen or recovery may be delayed, and serious diseases such as myocardial infarction and stroke may result.

According to a survey by the National Health Insurance Corporation, from 2012 to 2016, the number of patients who received hospital treatment for insomnia increased by 34.3% from 403,417 in 2012 to 541,958 in 2016. It was found that more than 50% of the

As a result of a sleep survey of 773 office workers, 75.7% responded that they lacked sleep, and it was found that 6 hours was 2 hours less than the OECD average of 8 hours. showed

In order to treat these sleep disorders, chemical hypnotic agents that reversibly suppress the central nervous system to induce sleep and maintain a sleep state are used. Conventional sleeping pills have a central depressant action like anesthetics, so that a small amount of sedative action and a moderate amount of sleep action are performed, but a large amount of the drug has coma, paralysis, and respiratory depression. Barbital drugs have a problem with low safety and easy tolerance and dependence.

In order to improve these problems, sleep-related technologies are being actively developed, but these sleep-related technologies are concentrated in the sleep-tech industry using AI, IoT, and big data, and in the food sector, Medifood (supplements), As the fields such as herbal tea are limited, it is necessary to discover various materials and develop technologies.

On the other hand, Heukharang lettuce is a lettuce developed to differentiate it from commercial varieties by collecting our own native seeds, which have been disappearing since 2011, at the Jeonnam Agricultural Research and Extension Services. It is a new variety applied for variety protection in Jeollanam-do in 016.

Heukharang lettuce is characterized by a strong bitter taste due to its black-red leaf color and higher lactucin content than ordinary lettuce. It is also known to help relieve stress.

As the market for non-psychoactive insomnia treatments is rapidly growing due to the side effects of chemical sleeping pills, interest in using Heukharang varieties with high lactucin content is increasing as pharmaceutical companies are turning to plant-based natural substitutes.

As a prior art, Korean Patent Registration No. 10-0947353 (title of invention: health food composition for improvement of sleep disorders and good sleep) has been registered.

In order to solve the above problems, the present invention is a medi-food composition for inducing deep sleep that can greatly improve the quality of sleep by shortening the waking time by using the black harang lettuce extract, and taking a deep sleep without waking up at night. It aims to provide

In order to solve the above problems, the medi-food composition for inducing deep sleep according to an embodiment of the present invention includes a black harang lettuce extract, and includes at least one of a valerian extract and an herbal extract, and the herbal extract, It is characterized in that it is an extract comprising at least one of lavender, chamomile, peppermint and rosemarine.

Here, the Heukharang lettuce extract is characterized in that it is extracted from the dried Heukharang lettuce having a lactucin and lactucopicrin content of 0.025 to 0.124 mg/g.

In addition, the heukharang lettuce extract, a drying step of drying the heukharang lettuce; Grinding step of pulverizing the dried heukharang lettuce; An extraction step of extracting the Heukharang lettuce extract by adding 5 to 15 parts by weight of the pulverized Heukharang lettuce powder to 150 to 300 parts by weight of the solvent, and a filtration step of filtering the Heukharang lettuce powder with a filter cloth after the extraction step. characterized by being

In addition, the drying step is characterized in that the heukharang lettuce is dried for 20 to 30 hours at a temperature of 50 to 59 ℃.

In addition, the extraction step is characterized in that the extraction of the black harang lettuce extract at a temperature of 55 to 85 ℃ for 3 to 5 hours.

In addition, the medi-food composition, including 20 to 35 parts by weight of the black harang lettuce extract, may include at least one of 12 to 23 parts by weight of the valerian extract and 4 to 12 parts by weight of the herbal extract.

In addition, it is possible to provide a medi-food for inducing deep sleep comprising the composition of any one of claims 1 to 6.

In addition, the medi-food for inducing deep sleep further includes a drug, and the drug may include one or more of burnet, lower leaf, and St. John's grass.

In addition, the medicine is characterized in that it is used in the form of an extract prepared by inoculating lactic acid bacteria after pasteurizing the dried powdered medicine, fermenting it at 35 to 50° C., and filtering it.

The medi-food composition for inducing deep sleep according to an embodiment of the present invention as described above uses the black harang lettuce extract to shorten the waking time and to take a deep sleep without waking up at night, thereby greatly improving the quality of sleep. .

Hereinafter, the description of the present invention with reference to the drawings is not limited to specific embodiments, and various modifications may be made and various embodiments may be provided. In addition, it should be understood that the contents described below include all transformations, equivalents, and substitutes included in the spirit and scope of the present invention.

In the following description, terms such as 1st, 2nd, etc. are terms used to describe various components, meanings are not limited thereto, and are used only for the purpose of distinguishing one component from other components.

Like reference numbers used throughout this specification refer to like elements.

As used herein, the singular expression includes the plural expression unless the context clearly dictates otherwise. In addition, terms such as "comprises", "comprises" or "have" described below are intended to designate the existence of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification. It should be construed as not precluding the possibility of addition or existence of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

Hereinafter, embodiments of the present invention will be described in detail.

Including the Heukharang lettuce extract according to an embodiment of the present invention, it may include at least one of a valerian extract and an herbal extract.

In this case, the medi-food composition includes 20 to 35 parts by weight of Heukharang lettuce extract, 12 to 23 parts by weight of valerian extract and 4 to 12 parts by weight of herbal extract, and 28 parts by weight of Heukharang lettuce extract. , It is most preferred to include 18 parts by weight of valerian extract and 6 parts by weight of herbal extract.

First of all, Heukharang lettuce extract is an extract of Heukharang lettuce, a new variety newly developed through an indigenous variety in Korea in 2016. Lactusin not only relieves tension and calms the mind, but also has an analgesic effect, which helps to improve insomnia and stress.

Heukharang lettuce of 1 to 4 leaves may be used depending on the collection period, and the length of the Heukharang lettuce is 120 to 230 mm, and the width is preferably 80 to 100 mm.

When the length and width of Heukharang lettuce is less than the lower limit or exceeds the upper limit, the lactucin and lactucopicrin contents are low from the Heukharang lettuce extract, which is undesirable.

In addition, it is most preferable to use Heukharang lettuce extract extracted from dried Heukharang lettuce having a lactucin or lactucopicrin content of 0.025 to 0.124 mg/g or more, but is not limited thereto.

Here, when the Heukharang lettuce extract is added in an amount of less than 12 parts by weight, the effect of lactucin is insignificant, and when it exceeds 23 parts by weight, the palatability of the medi-food deteriorates due to the characteristic bitter taste of Heukharang lettuce, which is not preferable.

In addition, the black harang lettuce extract may be extracted through a drying step, a grinding step, an extraction step, and a filtration step.

First, the drying step is a step of drying Heukharang lettuce. The Heukharang lettuce can be dried at a temperature of 50 to 59 ° C. for 20 to 30 hours, and most preferably drying at a temperature of 55 ° C. for 24 hours, but is not limited thereto. does not

When the Heukharang lettuce is dried under these conditions, the drying yield of the Heukharang lettuce may be 6 to 16%, and most preferably 10%, but is not limited thereto.

In addition, when the heukharang lettuce is dried below the lower limit, the heukharang lettuce is not sufficiently dried, so it has a unique grassy odor and fishy smell, which results in low palatability. It is undesirable because the content of tucin is low.

The grinding step is a step of pulverizing the dried heukharang lettuce. By grinding the dried heukharang lettuce with a grinder, powdered heukharang lettuce can be obtained.

The extraction step is a step of extracting the Heukharang lettuce extract from the Heukharang lettuce powder, and may be extracted by adding the Heukharang lettuce powder to the solvent.

In addition, the black harang lettuce extract can be extracted by adding 5 to 15 parts by weight of black harang lettuce powder to 150 to 300 parts by weight of the solvent, and it is most preferable to add 10 parts by weight of black harang lettuce powder to 200 parts by weight of the solvent, but is not limited thereto. does not

At this time, in extracting the Heukharang lettuce extract, if it is added below the lower limit, the amount of the Heukharang lettuce extract may be small.

Here, the solvent may include at least one of purified water and alcohol, and it is most preferable to use a solvent in which purified water and alcohol are mixed in an 8:2 ratio, but is not limited thereto.

In addition, in the extraction step, after adding black harang lettuce powder to the solvent, extraction may be performed at a temperature of 55 to 85° C. for 3 to 5 hours, and extraction at 80° C. for 4 hours is most preferable.

In this case, when the extraction is performed less than the lower limit or exceeding the upper limit of the temperature or time, the lactucin content included in the Black Harang lettuce extract is reduced, which is not preferable.

Valerian extract is a valerian extract. Valerian is a perennial herb from the Matariaceae family, which has the effect of relieving spasms and relieving tension to help you sleep better. and is said to be effective against bruises.

In addition, in Europe, it is known for its excellent natural insomnia effect, so it is the most sold natural herb every year, and more than 50 tons are sold a year. In particular, the root of valerian is known to be rich in essential oils, so it has excellent anti-hysterical properties and has a strong effect on mental anxiety, irritability, nervous breakdown, and hysteria.

When this valerian extract is less than 12 parts by weight, the effect due to valerian is insignificant, and when it exceeds 23 parts by weight, the taste of medi-food may be deteriorated due to the unique scent and taste of valerian.

The herbal extract is an extract extracted from herbs, and may include one or more of lavender, chamomile, peppermint, and rosemarine.

At this time, the herbal extract may include 4 to 8 parts by weight of lavender, 3 to 10 parts by weight of chemomile, 2 to 5 parts by weight of peppermint, and 3 to 7 parts by weight of rosemarine, 5 parts by weight of lavender, 4 parts by weight of chemomile, 3 parts by weight of peppermint parts and 6 parts by weight of rosemarine.

First, lavender refers to all about 25 plants belonging to the genus Lamiaceae and Labandua, or one species of dicotyledonous plants.

The scent of lavender contains a large amount of acetic acid nallinyl, pinalol, pinene, limonene, geraniol, and siol, which stimulates the central nervous system and helps to stabilize the nerves. It is said to be effective in relieving symptoms such as fatigue and fatigue.

At this time, when the amount of lavender is less than 4 parts by weight, the effect due to lavender is insignificant, and when it exceeds 8 parts by weight, the palatability is deteriorated due to the strong scent of lavender and it is not preferable because it may cause a headache.

Chamomile is a plant in the daisy family, which means apple from the ground, and has been a medicinal herb for treating diseases thanks to various ingredients that help health since ancient times.

These chemomiles contain terpenes and flavonoids, which are very strong in antioxidants, and are very helpful in promoting health. It is said to be effective.

In this case, when the amount of chemomile is less than 3 parts by weight, the effect due to chemomile is insignificant, and when it exceeds 10 parts by weight, the taste is deteriorated due to the strong scent of chemomile, and it is not preferable because it may cause a headache.

Peppermint, belonging to the Asteraceae family, is a perennial herb with a strong fragrance and is widely cultivated around the world, and is said to be used as a raw material for food and cosmetic additives and pharmaceuticals. In addition, effects such as antioxidant, anti-inflammatory, anti-allergic, anti-viral, and antibacterial have been reported.

At this time, when the amount of peppermint is less than 2 parts by weight, the effect due to peppermint is insignificant, and when it exceeds 5 parts by weight, the palatability is deteriorated due to the unique flavor and taste of peppermint, and it is not preferable because it can cause a headache.

Rosemarine is an evergreen shrub native to the Mediterranean coast. It is an herb with a fresh and strong scent similar to camphor on sharp leaves like pine leaves. It has been mainly used as a perfume and medicine. It is known to enhance the preservation of food, such as its role, sterilization, antibacterial and antioxidant effects.

When the amount of rosemarine is less than 3 parts by weight, the effect due to rosemarine is insignificant, and when it exceeds 7 parts by weight, the palatability may deteriorate due to the strong scent of rosemarine, which is not preferable.

In addition, the medi-food for inducing deep sleep according to an embodiment of the present invention may further include a drug to add auxiliary efficacy.

At this time, the drug may include 1 to 4 parts by weight of the medi-food composition for inducing deep sleep, and 2 parts by weight is most preferred.

In addition, the medicinal material may include one or more of burnet, lower leaves, and St. John's grass.

At this time, the medicinal material may include 0.2 to 0.8 parts by weight of burnet, 0.1 to 0.3 parts by weight of the lower leaf, and 0.3 to 0.6 parts by weight of St. John's grass, and it is most preferable to include 0.5 parts by weight of burnet, 0.2 parts by weight of the lower leaf, and 0.4 parts by weight of St. John's grass. Do.

Burnet is a perennial plant that has strong cold resistance, grows well in any soil, and is easy to cultivate.

This burnet has a tonic effect and makes you feel good, so it was used to get rid of depression. It is also used as a preventative to protect the body from infectious diseases.

At this time, when the burnet is less than 0.2 parts by weight, the effect due to the burnet is insignificant, and when it exceeds 0.8 parts by weight, the unique flavor of the burnet may impair the palatability of Medifood.

The lower leaf is also called lotus leaf, and as a pharmacological action, it is used for diarrhea, headache and dizziness, hematemesis, bleeding such as nosebleeds, postpartum eohyeol treatment, enuresis, and neutralizes various toxic substances. In particular, for smokers, it has a detoxifying effect that removes nicotine. In addition, in general, lotus leaves purify blood with detoxifying effects, and are known to have hemostasis, antibacterial and blood pressure lowering effects. It is said that it has the effect of relaxing a woman's womb and getting rid of bad blood. As a tea using lotus leaves, there is Gambicha (減肥茶) from Chinese ancient times (contains lotus leaf, adil radish, hawthorn, dermis, etc.), which is known to be effective for diet and skin care.

At this time, when the lower leaf is less than 0.1 parts by weight, the effect due to the lower leaves is insignificant, and when it exceeds 0.3 parts by weight, the palatability of Medifood may be deteriorated due to the bitter taste caused by the lower leaf.

St. John's Grass is a medicinal herb known to be good for fibromyalgia and is mainly used to treat depression, and is known to be effective in treating depression.

In addition, St. John's grass is said to reduce pain and help treat insomnia.

When this St. John's grass is less than 0.3 parts by weight, the effect due to St. John's grass is insignificant, and when it exceeds 0.6 parts by weight, it is undesirable because it affects the taste of medi food due to the unique bitter taste of St. John's grass.

In addition, the medicine of the medi-food for inducing deep sleep according to an embodiment of the present invention may be in the form of an extract.

In more detail, after pasteurization treatment of dry powdered medicinal materials, lactic acid bacteria are inoculated, fermented at 35 to 50 ° C. for 4 to 7 days, and filtered to prepare, and fermentation at 45 ° C. for 6 days is the most preferable. not limited

At this time, when the fermentation temperature of the drug inoculated with lactic acid bacteria is less than 35 ℃, the fermentation of the drug occurs insignificantly. It is undesirable as it may affect the smell.

In addition, if the fermentation period of the drug inoculated with lactic acid bacteria is less than 4 days, the effect of using the drug in the form of an extract is insignificant because the drug is not sufficiently fermented. don't

As such, by using the drug in the form of an extract, not only the efficacy of the drug is maximized, but also the immunity is improved due to the lactic acid bacteria.

As described above, the medi-food composition for inducing deep sleep according to an embodiment of the present invention can significantly improve the sleep quality of consumers with sleep disorders by manufacturing medi-food using black harang lettuce, which is helpful for deep sleep. there is.

Hereinafter, the medi-food composition for inducing deep sleep of the present invention will be described in detail through Examples, Comparative Examples, and Experimental Examples.

Hereinafter, experimental examples carried out are presented to aid understanding, and are merely illustrative of the present invention, and the scope of the present invention is not limited to the following experimental examples.

[Experimental Example 1] Contents of lactucin and lactucopicrin according to extraction time

The contents of lactucin and lactucopicrin extracted according to the extraction time of Heukharang lettuce of the present invention were investigated.

First, one leaf of Heukharang lettuce was dried at 55°C for 24 hours using a hot air dryer, and then 200 ml of purified water as an extraction solvent was added to 10 g of pulverized dried Heukharang lettuce powder and extracted at a temperature of 80°C.

As described above, the contents of lactucine and lactucopicrin were determined by analysis by HPLC.

The results are shown in Table 1 below.

extraction time Lactucine (mg/g) Lactucopicrin (mg/g) 2 hours 0.007 0.011 4 hours 0.009 0.010 6 hours 0.005 0.009

As can be seen from Table 1, when the extraction time was 4 hours, it was confirmed that the contents of lactucine and lactucoficrin were the highest.

Accordingly, the extraction time of Heukharang lettuce was set to 4 hours.

[Experimental Example 2] Contents of lactucin and lactucopicrin according to the extraction temperature

The contents of extracted lactucin and lactucopicrin according to the extraction temperature of Heukharang lettuce of the present invention were investigated.

Extraction was performed under the same conditions as in Experimental Example 1 except for the extraction temperature and extraction time.

Here, the extraction time was set to 4 hours through Experimental Example 1.

The results are shown in Table 2 below.

Extraction temperature (℃) Lactucine (mg/g) Lactucopicrin (mg/g) 60℃ 0.030 0.008 80℃ 0.009 0.010 100℃ 0.012 0.008

As can be seen from Table 2, when the extraction temperature was 60° C., it was confirmed that the contents of lactucine and lactucopiacrin were the highest.

Accordingly, the extraction temperature of Heukharang lettuce was set to 60 ℃.

[Example]

[Example 1]

A medi-food for inducing deep sleep was prepared, including 25 parts by weight of heukharang lettuce extract, 15 parts by weight of valerian extract and 10 parts by weight of herbal extract (5 parts by weight of lavender, 4 parts by weight of chemomile).

[Example 2]

A medi-food for inducing a good night's sleep, including 28 parts by weight of black harang lettuce extract, 18 parts by weight of valerian extract, and 4 parts by weight of herbal extract (5 parts by weight of lavender, 4 parts by weight of chemomile, 3 parts by weight of peppermint and 6 parts by weight of rosemarine) prepared.

[Example 3]

24 parts by weight of black harang lettuce extract, 18 parts by weight of valerian extract, 6 parts by weight of herbal extract (5 parts by weight of lavender, 4 parts by weight of chemomile, 3 parts by weight of peppermint and 6 parts by weight of rosemarine) and 2 parts by weight of medicinal substances (burnet 0.5 parts by weight) Part, 0.2 parts by weight of the lower leaf and 0.4 parts by weight of St. John's grass) for inducing a deep sleep was prepared.

[Comparative Example 1]

A medi-food for inducing deep sleep was prepared, including 18 parts by weight of black harang lettuce extract, 20 parts by weight of valerian extract and 12 parts by weight of herbal extract (5 parts by weight of lavender, 4 parts by weight of chemomile).

[Comparative Example 2]

A medi-food for inducing a good night's sleep, comprising 20 parts by weight of heukharang lettuce extract, 26 parts by weight of valerian extract, and 4 parts by weight of herbal extract (5 parts by weight of lavender, 4 parts by weight of chemomile, 3 parts by weight of peppermint and 6 parts by weight of rosemarine) prepared.

[Comparative Example 3]

Heukharang lettuce extract 24 parts by weight, valerian extract 15 parts by weight, herbal extract 5 parts by weight (lavender 5 parts by weight, chemomile 4 parts by weight, peppermint 3 parts by weight and rosemarine 6 parts by weight) and 6 parts by weight of medicinal substances (burnet 0.5 parts by weight) Part, 0.2 parts by weight of the lower leaf and 0.4 parts by weight of St. John's grass) for inducing deep sleep was prepared.

[Experimental Example 3] Sensory evaluation

Examples 1 to 3 and Comparative Examples 1 to 3 were subjected to sensory evaluation.

Among trained professional sensory test agents (50 [25 men, 25 women] with more than 2 years of sensory test experience), 30 people with relatively excellent taste were selected and divided into taste, scent and preference for quantitative descriptive analysis (Quantitative Descriptive Analysis (QDA) was performed. The sensory test was performed using a 5-point measurement method (1: very bad, 2: bad, 3: average, 4: good, 5: very good). The results are shown in Table 3 below.

taste incense symbol Example 1 4.02 4.21 4.33 Example 2 4.19 4.34 4.42 Example 3 3.91 4.17 4.32 Comparative Example 1 3.21 3.17 3.61 Comparative Example 2 3.17 3.33 3.12 Comparative Example 3 2.34 3.78 3.61

As can be seen from Table 3, it was confirmed that Examples 1 to 3 were superior to Comparative Examples 1 to 3 in all items.

Although embodiments of the present invention have been described above with reference to the accompanying drawings, those of ordinary skill in the art to which the present invention pertains can practice the present invention in other specific forms without changing the technical spirit or essential features of the present invention. you will be able to understand Accordingly, the embodiments described above are illustrative in all respects and not restrictive.

Claims (7)

Including black harang lettuce extract,
at least one of a valerian extract and an herbal extract;
The herbal extract is
A medi-food composition for inducing deep sleep, characterized in that it is an extract comprising at least one of lavender, chamomile, peppermint and rosemarin.
According to claim 1,
The black harang lettuce extract,
A medi-food composition for inducing deep sleep, characterized in that it is extracted from dried heukharang lettuce having a lactucine or lactucopicrin content of 0.025 to 0.124 mg/g.
According to claim 1,
The black harang lettuce extract,
Drying step of drying the heukharang lettuce;
Grinding step of pulverizing the dried heukharang lettuce;
An extraction step of extracting the Heukharang lettuce extract by adding 5 to 15 parts by weight of the pulverized Heukharang lettuce powder to 150 to 300 parts by weight of the solvent;
After the extraction step, the medi-food composition for inducing deep sleep, characterized in that extracted through a filtering step of filtering the black harang lettuce powder with a filter cloth.
4. The method of claim 3,
The drying step is
A medi-food composition for inducing deep sleep, characterized in that the black harang lettuce is dried at a temperature of 50 to 59 °C for 20 to 30 hours.
4. The method of claim 3,
The extraction step is
A medi-food composition for inducing deep sleep, characterized in that the extract of black harang lettuce is extracted at a temperature of 55 to 85 °C for 3 to 5 hours.
According to claim 1,
The medi food composition,
Including 20 to 35 parts by weight of the black harang lettuce extract,
A medi-food composition for inducing deep sleep comprising at least one of 12 to 23 parts by weight of a valerian extract and 4 to 12 parts by weight of an herbal extract.
A medi-food for inducing deep sleep comprising the composition of any one of claims 1 to 6.