KR20220030248A - 4-1bb 공동자극 도메인을 갖는 키메라 항원 수용체 - Google Patents

4-1bb 공동자극 도메인을 갖는 키메라 항원 수용체 Download PDF

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KR20220030248A
KR20220030248A KR1020227001944A KR20227001944A KR20220030248A KR 20220030248 A KR20220030248 A KR 20220030248A KR 1020227001944 A KR1020227001944 A KR 1020227001944A KR 20227001944 A KR20227001944 A KR 20227001944A KR 20220030248 A KR20220030248 A KR 20220030248A
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cancer
cells
antigen
cell
domain
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KR1020227001944A
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English (en)
Korean (ko)
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권병에스.
김광희
정지원
장영균
이보림
이정윤
이새롬
손현태
이혜미
유은혜
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주식회사 유틸렉스
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Priority claimed from PCT/KR2019/010244 external-priority patent/WO2020032784A1/ko
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Publication of KR20220030248A publication Critical patent/KR20220030248A/ko

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KR1020227001944A 2019-06-27 2020-06-26 4-1bb 공동자극 도메인을 갖는 키메라 항원 수용체 KR20220030248A (ko)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201962867503P 2019-06-27 2019-06-27
US62/867,503 2019-06-27
KRPCT/KR2019/010244 2019-08-12
PCT/KR2019/010244 WO2020032784A1 (ko) 2018-08-10 2019-08-12 Hla-dr에 결합하는 키메라 항원 수용체 및 car-t 세포
US16/715,462 2019-12-16
US16/715,462 US11013765B2 (en) 2018-08-10 2019-12-16 Chimeric antigen receptor that binds HLA-DR and CAR-T cell
US202062991493P 2020-03-18 2020-03-18
US62/991,493 2020-03-18
US202063004827P 2020-04-03 2020-04-03
US63/004,827 2020-04-03
US202063043237P 2020-06-24 2020-06-24
US63/043,237 2020-06-24
PCT/IB2020/056097 WO2020261231A1 (en) 2019-06-27 2020-06-26 Chimeric antigen receptor with 4-1bb costimulatory domain

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EP (1) EP3990626A4 (zh)
JP (1) JP2022538425A (zh)
KR (1) KR20220030248A (zh)
CN (1) CN114080452A (zh)
AU (1) AU2020307673A1 (zh)
BR (1) BR112021026406A2 (zh)
CA (1) CA3144875A1 (zh)
MX (1) MX2021015967A (zh)
WO (1) WO2020261231A1 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114007642A (zh) 2019-04-30 2022-02-01 森迪生物科学公司 嵌合受体及其使用方法
KR102671410B1 (ko) * 2021-03-03 2024-06-04 진화섭 RANK 리간드(RANK ligand)에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050113564A1 (en) * 2003-11-05 2005-05-26 St. Jude Children's Research Hospital Chimeric receptors with 4-1BB stimulatory signaling domain
JP4331227B2 (ja) * 2004-07-09 2009-09-16 中外製薬株式会社 抗グリピカン３抗体
AU2013204922B2 (en) * 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
US20160280798A1 (en) * 2013-11-06 2016-09-29 The United States Of America, As Represented By The Secretary Department Of Health & Human Service Alk antibodies, conjugates, and chimeric antigen receptors, and their use
CN106536564B (zh) * 2014-06-02 2021-08-31 美国卫生和人力服务部 靶向cd-19的嵌合抗原受体
US10195272B2 (en) * 2015-03-02 2019-02-05 The Nemours Foundation Adoptive t-cell therapy using FcεRI-based chimeric antigen receptors for treating IgE-mediated allergic diseases
CN107847601A (zh) * 2015-06-04 2018-03-27 南加利福尼亚大学 Lym‑1和lym‑2靶向的car细胞免疫疗法
EP3359562B1 (en) * 2015-10-09 2019-12-04 Miltenyi Biotec Technology, Inc. Chimeric antigen receptors and methods of use
CN106279438B (zh) * 2016-08-24 2019-10-22 北京领柯生物科技有限公司 新型嵌合抗原受体及其用途
WO2018106993A1 (en) * 2016-12-09 2018-06-14 H. Lee Moffitt Cancer Center And Research Institute Inc. Tlr9-binding chimeric antigen receptors
EP3568469A4 (en) * 2017-02-21 2020-11-11 Eutilex Co., Ltd. HLA-DR-CART COMPOSITIONS AND METHOD OF MANUFACTURING AND USING THEREOF
WO2018156711A1 (en) * 2017-02-22 2018-08-30 H. Lee Moffitt Cancer Center And Research Institute, Inc. Il13ra2-binding chimeric antigen receptors
WO2018236909A1 (en) * 2017-06-20 2018-12-27 La Jolla Institute For Allergy And Immunology T-MODIFIED LYMPHOCYTE RECEPTORS AND METHODS OF USE IN INFLAMMATORY RESPONMS MODULATION AND ATHEROSCLEROSIS TREATMENT
JP7237926B2 (ja) * 2017-07-31 2023-03-13 レンティジェン・テクノロジー・インコーポレイテッド 抗ｃｄ１９／ｃｄ２０免疫療法によりがんを処置するための組成物および方法
CN108715859B (zh) * 2018-05-31 2021-08-03 中国医学科学院血液病医院(中国医学科学院血液学研究所) 靶向cd22的嵌合抗原受体及其应用

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CN114080452A (zh) 2022-02-22
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BR112021026406A2 (pt) 2022-04-12
EP3990626A4 (en) 2023-09-20
MX2021015967A (es) 2022-04-06
WO2020261231A1 (en) 2020-12-30
AU2020307673A1 (en) 2022-01-20

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