KR20220013224A - Cosmetic Composition for Smoothing Skin Containing Oryza Sativa Extract, Avena Sativa Kernel Extract and Cocos Nucifera Oil As Active Ingredient - Google Patents

Abstract

The present invention relates to a composition for soothing skin and alleviating irritation comprising a rice extract, an oat kernel extract, and coconut palm oil as an active ingredient. Specifically, in the present invention, the rice extract, the oat kernel extract, and the coconut palm oil are mixed in a specific weight ratio, thereby having a synergistic effect on soothing skin and alleviating irritation than when each component is used individually and also having high economic efficiency.

Description

Cosmetic Composition for Smoothing Skin Containing Oryza Sativa Extract, Avena Sativa Kernel Extract and Cocos Nucifera Oil As Active Ingredient containing rice extract, oat kernel extract and coconut palm oil as active ingredients

The present invention relates to a skin soothing cosmetic composition comprising rice extract, oat kernel extract and coconut palm oil as active ingredients. Specifically, the present invention relates to a cosmetic composition having a synergistic effect in soothing skin troubles than when using each component individually by mixing and including rice extract, oat kernel extract and coconut palm oil in a specific ratio.

Human skin experiences various skin troubles due to environmental changes and stress. In the case of infancy, skin problems such as atopic dermatitis are experienced, and in adolescence, acne due to excessive sebum secretion is experienced. In addition, it is easily sensitive to weak external stimuli and it takes a long time to recover. In particular, in recent years, various cosmetics are used and skin troubles are also becoming very diverse. Therefore, many efforts are being made to solve these skin troubles, and the representative method is to use natural plant ingredients to solve it, Many of these methods are used in

Korean Patent No. 10-1332214 discloses a cosmetic composition for relieving skin stress comprising a complex fermented extract of lotus flower, rice, and wormwood. In addition, Korean Patent Application Laid-Open No. 2015-0041938 discloses a cosmetic composition for skin protection including vegetable oil such as coconut oil.

The present inventors conducted research to develop a composition with excellent skin soothing and irritation alleviation effects, and as a result, among various substances, when rice extract, oat kernel extract, and coconut palm oil are used at the same time, synergistic effect is higher than when each is used. It was confirmed that the It is an object of the present invention to provide a cosmetic composition for skin soothing and irritation relief containing rice extract, oat kernel extract and coconut palm oil in a specific central ratio.

The above object is achieved by a cosmetic composition for skin soothing and irritation relief containing rice extract, oat kernel extract and coconut palm oil as active ingredients.

Preferably, the rice extract, oat kernel extract and coconut palm oil may be included in a weight ratio of 16 to 32: 4 to 8: 60 to 70.

Also preferably, the rice extract, oat kernel extract and coconut palm oil may be contained in an amount of 0.0001 to 10.0% by weight based on the total weight of the cosmetic composition.

Also preferably, the cosmetic composition may have a formulation selected from the group consisting of softening lotion, astringent lotion, nourishing lotion, nourishing cream, massage cream, essence, pack, oil balm, water-soluble gel, detergent, cleansing foam, and makeup cleansing. have.

The cosmetic composition comprising the rice extract, oat kernel extract and coconut palm oil of the present invention has a synergistic effect in soothing and alleviating skin irritation, and also has excellent skin soothing and irritation alleviation effects at a specific mixing ratio and content.

All technical terms used in the present invention, unless otherwise defined, have the following definitions and have the meanings as commonly understood by one of ordinary skill in the art of the present invention. In addition, although preferred methods and samples are described herein, similar or equivalent ones are also included in the scope of the present invention.

The term "about" means 30, 25, 20, 15, 10, 9, 8, 7, 6, 5, means an amount, level, value, number, frequency, percentage, dimension, size, amount, weight or length varying by 4, 3, 2 or 1%.

Throughout this specification, unless the context requires otherwise, the terms "comprises" and "comprising" include, but are not limited to, a given step or element, or group of steps or elements, but any other step or element, or It is to be understood that a step or group of elements is not excluded.

The present invention is to provide a cosmetic composition for skin soothing and irritation relief containing rice extract, oat kernel extract and coconut palm oil as active ingredients.

Rice extract is an extract obtained after grinding or grinding rice (Oryza Sativa). Preferably, it may be extracted after pulverizing unpolished rice. Rice is a grass belonging to the subfamily Rice, and is cultivated in paddy fields or fields, and is cultivated in various countries such as Korea, southern China, Myanmar, Thailand, and India. Rice contains protein, small amounts of fat, minerals, vitamins, and dietary fiber.

The oat kernel extract is an extract obtained after grinding the refined grains (kernels) of oats (Avena Sativa). Oats are plants of the genus Avena of the Poapuaceae family and the genus of oats, and their origin is West Asia, and they are widely cultivated in Eastern Europe and Northern Europe, and the largest production area is Russia. Oats contain protein, vitamins, and carbohydrates, and are known to have effects such as cholesterol control, antioxidant effect, and digestion promotion.

In the present invention, the rice extract and oat kernel extract can be prepared according to a conventional method known in the art. For example, (a) a solvent extraction method, (b) a supercritical extraction method using reduced pressure and high temperature with carbon dioxide, or (c) an ultrasonic extraction method can be used for extraction.

In the present invention, preferably, a solvent extraction method using an extraction solvent was used.

In the present invention, rice extract and oat kernel extract are prepared using various extraction solvents, for example, water, anhydrous or hydrous lower alcohols having 1-4 carbon atoms (eg, methanol, ethanol, propanol and butanol), propylene glycol, 1,3 -It can be obtained using one or more extraction solvents selected from the group consisting of -butylene glycol, glycerin, acetone, diethyl ether, ethyl acetate, butyl acetate, dichloromethane, chloroform, nucleic acids, and mixtures thereof, preferably It is obtained by using 1,3-butylene glycol.

The extraction method by the supercritical extraction method by the reduced pressure by carbon dioxide and the high temperature refers to the supercritical fluid extraction method, and in general, the supercritical fluid is a liquid having a gas when it reaches a critical point under high temperature and high pressure conditions, and It has gaseous properties and chemically has a polarity similar to that of a non-polar solvent. Due to these properties, supercritical fluids are used for the extraction of fat-soluble substances (J. Chromatogr. A. 1998;479:200-205).

Carbon dioxide becomes a supercritical fluid with both liquid and gas properties as the pressure and temperature reach the critical point through the operation of the supercritical fluid device, and as a result, the solubility in fat-soluble solutes increases. When the supercritical carbon dioxide passes through an extraction vessel containing a certain amount of the sample, the fat-soluble substance contained in the sample is extracted into the supercritical carbon dioxide.

After extracting the fat-soluble substance, if supercritical carbon dioxide containing a small amount of co-solvent is again flowed through the sample remaining in the extraction container, components that were not extracted with pure supercritical carbon dioxide alone can be extracted.

The supercritical fluid used in the supercritical extraction method of the present invention can effectively extract the active ingredient by using supercritical carbon dioxide or a mixed fluid in which a cosolvent is additionally mixed with carbon dioxide.

As the co-solvent, one or a mixture of two or more selected from the group consisting of chloroform, olive oil, ethanol, methanol, water, ethyl acetate, nucleic acid and diethyl ether may be used. Preferably, one or a mixture of two or more selected from the group consisting of olive oil, ethanol, methanol, and water may be used.

Most of the extracted samples contain carbon dioxide, and since carbon dioxide is volatilized into the air at room temperature, the extract obtained by the above method can be used as a cosmetic composition, and the cosolvent can be removed by a vacuum evaporator.

In addition, the ultrasonic extraction method is an extraction method using energy generated by ultrasonic vibration, and ultrasonic waves can destroy an insoluble solvent contained in a sample in an aqueous solvent. Because the kinetic energy of the particles is increased, sufficient energy required for the reaction is obtained, and the high pressure is induced by the impact effect of ultrasonic energy to increase the mixing effect of the material and the solvent contained in the sample, thereby increasing the extraction efficiency.

The extraction solvent that can be used for the ultrasonic extraction method may be one or a mixture of two or more selected from the group consisting of chloroform, ethanol, methanol, water, ethyl acetate, nucleic acid, and diethyl ether. The extracted sample is vacuum filtered to recover the filtrate, then removed by a vacuum evaporator, and an extract can be obtained through a conventional extract preparation method of freeze-drying.

Coconut palm oil is a nonvolatile oil that can be obtained by pressing after removing the seed coat of the cocos palm tree, and contains a large amount of vitamins, minerals, and lauric acid. Coconut palm oil is widely used for skin care and food, and is known for its excellent moisturizing effect. In the present invention, coconut palm oil can be obtained by removing the outer skin of the coconut, cutting the coconut to remove the coconut juice, separating the inner skin and flesh of the coconut, crushing the excess bath, and pressing with a press.

The present invention provides a cosmetic composition exhibiting a synergistic effect by including rice extract, oat kernel extract and coconut palm oil in a specific weight ratio.

According to one embodiment of the present invention, the cosmetic composition is characterized in that it contains rice extract, oat kernel extract and coconut palm oil mixed in a weight ratio of 16 to 32: 4 to 8: 60 to 70. More preferably, the rice extract, oat kernel extract and coconut palm oil are preferably mixed in a weight ratio of 32:8:60.

The rice extract, oat kernel extract and coconut palm oil are preferably included in an amount of 0.0001 to 10.0% by weight based on the total weight of the cosmetic composition. If it is less than 0.0001% by weight, the skin soothing and irritation alleviation effect is insignificant, and when it exceeds 10.0% by weight, the degree of increase in the skin moisturizing effect with respect to the content increase is insignificant. More preferably, it is included in an amount of 0.01 to 1.0% by weight. In particular, when it exceeds 1.0 wt%, it was confirmed that the effect did not significantly increase compared to the content, resulting in lower economic efficiency.

In order to select the mixing weight ratio, the inhibitory effect of IL-α secretion in keratinocytes was evaluated according to the mixing ratio of rice extract and oat kernel extract. In addition, in order to select the optimal content thereof, it was evaluated through an actual use test within the range of 0.0001% to 10.00% in the formulation.

The ingredients included in the cosmetic composition of the present invention may include ingredients commonly used in cosmetic compositions in addition to the active ingredient as an active ingredient, for example, conventional ingredients such as antioxidants, stabilizers, solubilizers, vitamins, pigments and fragrances. adjuvants, and carriers.

The cosmetic composition of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing , oil, powder foundation, emulsion foundation, wax foundation, pack, massage cream, spray, etc., but is not limited thereto. More specifically, it may be prepared in the form of a softening lotion, a nourishing lotion, a nourishing cream, a massage cream, an essence, a pack, an oil balm, a water-soluble gel, a cleansing foam, or a makeup cleanser.

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylglycol oil, glycerol fatty ester, polyethylene glycol or fatty acid ester of sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Adult cellulose, aluminum metahydroxide, bentonite, agar or tracanth may be used.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additional chlorofluorohydrocarbon, propane /may contain propellants such as butane or dimethyl ether.

In the case of cleansing in which the formulation of the present invention contains a surfactant, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid as carrier components Amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters can be used.

When the cosmetic composition of the present invention is a soap, a surfactant-containing cleansing formulation, or a surfactant-free cleansing formulation, it may be applied to the skin and then wiped off, removed, or washed off with water. As a specific example, the soap is liquid soap, powder soap, solid soap, and oil soap, the surfactant-containing cleansing formulation is a cleansing foam, cleansing water, cleansing towel, and cleansing pack, and the surfactant-free cleansing formulation is a cleansing cream , cleansing lotion, cleansing water, and cleansing gel, but not limited thereto.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention in more detail, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not limited by these examples according to the gist of the present invention. .

Example 1: Rice extract: Preparation of samples by composition of oat kernel extract

(1) Preparation of rice extract

First, unpolished rice is finely ground and prepared. 30% by weight of rice powder was placed in a mixture of 30% by weight of 1,3-butylene glycol and 40% by weight of purified water, immersed at 45° C. for about 48 hours, and first centrifuged to obtain a supernatant. This supernatant was subjected to secondary filtration through a ceramic filter with pores of 0.5 μm or less to obtain a liquid rice extract.

(2) Preparation of oat kernel extract

First, the milled oats are finely ground and prepared. 30% by weight of this oat powder is placed in a mixture of 30% by weight of 1,3-butylene glycol and 40% by weight of purified water, immersed at 45° C. for about 48 hours, and first centrifuged to obtain a supernatant, This supernatant was subjected to secondary filtration through a ceramic filter having a pore size of 0.5 μm or less to obtain a liquid oat kernel extract.

(3) Rice extract: Sample preparation by composition of oat kernel extract

A sample was prepared by mixing the rice extract and the oat kernel extract in the following weight ratio.

division rice extract oat kernel extract Preparation Example 1 0 100 Preparation 2 20 80 Preparation 3 40 60 Preparation 4 60 40 Preparation 5 80 20 Preparation 6 100 0

Experimental Example 1: Evaluation of IL-1α secretion inhibitory effect in HaCaT keratinocytes for a mixed sample of rice extract and oat kernel extract

HaCaT keratinocytes (German Cancer Research Institute, Germany) were inoculated with DMEM (Dulbeco's Modified Eagle's Medium, Gibco) supplemented with 10% FBS at a density of 2 × 10 ⁵ cells/well in a 24-well plate and humidified 37 ℃, 5% CO ₂ Cultured in an incubator for 1 day. After exchange with serum-free DMEM, all samples of Preparation Examples 1 to 6 were treated at 100 ppm and cultured for one day, and then treated with sodium dodecyl sulfate (Sigma) (SDS) and cultured for an additional 4 hours. After 4 hours, a portion of the culture medium was taken and used for IL-1α quantification and protein quantification. IL-1α quantification was performed according to the kit's IL-1α quantification method using Endogen's human IL-1α kit. The amount of IL-1α secretion per protein was measured. As a positive control, ketoprofen, which was previously used as a skin irritation alleviation material, was used, and the final IL-1α production rate (%) was obtained by Equation 1 below. The results are shown in Table 2.

[Equation 1]

Sample name IL-1α production rate (%) SDS only processing 100 ± 0.15 Preparation Example 1 90 ± 0.13 Preparation 2 85 ± 0.11 Preparation 3 80 ± 0.16 Preparation 4 78 ± 0.18 Preparation 5 76 ± 0.15 Preparation 6 88 ± 0.13 ketoprofen 55 ± 0.12

Referring to Table 2, in the sample of Preparation Example 5, it was found that the amount of IL-1α secretion from keratinocytes after SDS treatment was significantly reduced compared to other samples. In this experiment, the biosynthesis of IL-1α that can cause erythema that can occur on the skin was observed through SDS treatment. After calculating the amount of -1α produced, this is a percentage. That is, through this result, it can be said that the effect of alleviating troubles such as erythema that may occur on the skin by reducing the production of IL-1α in the sample of rice extract: oat kernel extract = 80: 20 (weight ratio) is great. .

Example 2: Mixing of the composition of Preparation Example 5 and coconut palm oil

(1) Coconut palm oil production

Remove the shell of the coconut, cut the coconut to remove the coconut juice, separate the inner shell and the pulp of the coconut, crush the coconut flesh to a size of 1 mm to 5 mm, press it with a press, and then centrifuge it, and freeze-dried Coconut palm oil was obtained through

(2) Mixing of the composition of Preparation Example 5 and coconut palm oil

division Rice Extract (80)+
Oat Kernel Extract (20) coconut palm oil Preparation 7 0 100 Preparation 8 20 80 Preparation 9 40 60 Preparation 10 60 40 Preparation 11 80 20

Experimental Example 2: Evaluation of IL-1α secretion inhibitory effect in HaCaT keratinocytes for a mixed sample of Preparation Example 5 and coconut palm oil

Experimental Example 2 was carried out in the same manner as Experimental Example 1.

Sample name IL-1α production rate (%) SDS only processing 100 ± 0.15 Preparation 7 75 ± 0.15 Preparation 8 67 ± 0.16 Preparation 9 60 ± 0.13 Preparation 10 73 ± 0.15 Preparation 11 74 ± 0.14 ketoprofen 55 ± 0.12

Referring to Table 4, in the sample of Preparation Example 9, it was found that the amount of IL-1α secretion from keratinocytes after SDS treatment was significantly reduced compared to other samples. Through this result, it can be said that the effect of alleviating troubles such as erythema that may occur on the skin by reducing the production amount of IL-1α in the sample of Preparation Example 5 composition: coconut palm oil = 40: 60 (weight ratio) is large. .

Example 3: Experiment by content in the formulation

Table 5 below shows that for Preparation Example 9, which showed the lowest amount of IL-1α production in Experimental Example 2, preparations were carried out for each content in the formulation. Formulation examples were prepared according to a conventional method in the cosmetic industry for preparing lotions. The unit is % by weight.

Prize ingredient Formulation Example 1 Formulation Example 2 Formulation Example 3 Formulation Example 4 Formulation Example 5 A Purified water To 100 To 100 To 100 To 100 To 100 AHA 3.0000 3.0000 3.0000 3.0000 3.0000 Disodium EDIT 0.0200 0.0200 0.0200 0.0200 0.0200 glycerin 2.8000 2.8000 2.8000 2.8000 2.8000 1,2-Hexanediol 2.0000 2.0000 2.0000 2.0000 2.0000 B Polyglyceryl-3 methylglucose distearate 1.6000 1.6000 1.6000 1.6000 1.6000 PEG-4 Oliveate 0.4000 0.4000 0.4000 0.4000 0.4000 cetearyl alcohol 0.2000 0.2000 0.2000 0.2000 0.2000 squalane 4.5000 4.5000 4.5000 4.5000 4.5000 Caprylic/Capric Triglycerides 4.2000 4.2000 4.2000 4.2000 4.2000 dimethicone 1.3000 1.3000 1.3000 1.3000 1.3000 C Purified water 2.9400 2.9400 2.9400 2.9400 2.9400 Acrylate/C10-30 alkyl acrylate crosspolymer 0.0600 0.0600 0.0600 0.0600 0.0600 D Purified water 0.0738 0.0738 0.0738 0.0738 0.0738 potassium hydroxide 0.0082 0.0082 0.0082 0.0082 0.0082 F Preparation 9
(Rice Extract + Oat Kernel Extract + Coconut Palm Oil) 0.0000 0.0001 0.0100 1.0000 10.0000

The manufacturing method is as follows. After heating the A and B phases to 75 ℃, mix with a homogenizer at 3000 rpm for 5 minutes. After cooling to 65°C, the C phase is added and mixed with a homogenizer at 3000 rpm for 3 minutes, and then the D phase is added and mixed with a homogenizer at 2800 rpm for 3 minutes. Finally, the F phase sample of Preparation Example 9 was added for each content and mixed at 2800 rpm for 3 minutes. Formulation Examples 1 to 5 were all prepared in the same manner.

Experimental Example 3: Skin irritation relief effect of cosmetics containing Preparation Example 9

The irritation-relieving effect of the cosmetic of the present invention was evaluated through an actual use test. That is, 150 women were divided into 5 parts and used for 2 weeks using both sides of the face to evaluate whether irritation appeared on the skin. The evaluated stimulus relief effect is shown in Table 6 below.

division no irritation mild irritation strong irritation Effectiveness (%) Formulation Example 1 One 4 25 3.33 Formulation Example 2 10 15 0 40.00 Formulation Example 3 15 10 0 60.00 Formulation Example 4 28 2 0 93.33 Formulation Example 5 28 2 0 93.33

Referring to Table 6 above, all of Formulation Examples 2 to 5 showed a very high alleviation effect compared to Formulation Example 1. However, the effective rate of Formulation Example 4 containing 1.00% by weight of the composition of Preparation Example 9 and the effective rate of Formulation Example 5 containing 10.00% by weight show the same value, and it is judged that economic efficiency is low at 1.00% or more.

As described above in detail a specific part of the present invention, for those of ordinary skill in the art, this specific description is only a preferred embodiment, and it is clear that the scope of the present invention is not limited thereto.

Claims (4)

A cosmetic composition for skin soothing and irritation relief containing rice extract, oat kernel extract and coconut palm oil as active ingredients. The cosmetic composition of claim 1, wherein the rice extract, oat kernel extract and coconut palm oil are included in a weight ratio of 16 to 32: 4 to 8: 60 to 70. The cosmetic composition for skin soothing and irritation relief according to claim 1, wherein the rice extract, oat kernel extract and coconut palm oil are contained in an amount of 0.0001 to 10.0% by weight based on the total weight of the cosmetic composition. According to claim 1, wherein the cosmetic composition has a formulation selected from the group consisting of softening lotion, astringent lotion, nutrient lotion, nourishing cream, massage cream, essence, pack, oil balm, water-soluble gel, detergent, cleansing foam, and makeup cleansing. A cosmetic composition for skin soothing and irritation relief, characterized in that.