KR20220003030A - 살아 있는 세포 계수 기술에 의한 유전적으로 조작된 미생물의 계수 - Google Patents

살아 있는 세포 계수 기술에 의한 유전적으로 조작된 미생물의 계수 Download PDF

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KR20220003030A
KR20220003030A KR1020217038657A KR20217038657A KR20220003030A KR 20220003030 A KR20220003030 A KR 20220003030A KR 1020217038657 A KR1020217038657 A KR 1020217038657A KR 20217038657 A KR20217038657 A KR 20217038657A KR 20220003030 A KR20220003030 A KR 20220003030A
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cells
pharmaceutical composition
live cells
approximately
gene
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Korean (ko)
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유진 안티포브
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신로직 오퍼레이팅 컴퍼니, 인코포레이티드
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    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
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KR1020217038657A 2019-04-29 2020-04-29 살아 있는 세포 계수 기술에 의한 유전적으로 조작된 미생물의 계수 Pending KR20220003030A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962840281P 2019-04-29 2019-04-29
US62/840,281 2019-04-29
US201962946785P 2019-12-11 2019-12-11
US62/946,785 2019-12-11
PCT/US2020/030468 WO2020223345A1 (en) 2019-04-29 2020-04-29 Enumeration of genetically engineered microorganisms by live cell counting techniques

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KR20220003030A true KR20220003030A (ko) 2022-01-07

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KR1020217038657A Pending KR20220003030A (ko) 2019-04-29 2020-04-29 살아 있는 세포 계수 기술에 의한 유전적으로 조작된 미생물의 계수

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US (1) US20220257732A1 (https=)
EP (1) EP3963046A1 (https=)
JP (1) JP2022530503A (https=)
KR (1) KR20220003030A (https=)
WO (1) WO2020223345A1 (https=)

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CN116847860A (zh) 2020-12-31 2023-10-03 同生运营公司 经工程化以减轻高苯丙氨酸血症的微生物
CN119162073A (zh) * 2024-11-01 2024-12-20 湖南省微生物研究院 一株柠檬酸杆菌基因工程菌株及其构建方法和应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9107305D0 (en) 1991-04-08 1991-05-22 Unilever Plc Probiotic
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US6203797B1 (en) 1998-01-06 2001-03-20 Stephen C. Perry Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome
EP1034787A1 (en) 1999-03-11 2000-09-13 Société des Produits Nestlé S.A. Lactobacillus strains preventing diarrhea caused by pathogenic bacteria
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
US7731976B2 (en) 2003-08-29 2010-06-08 Cobb And Company, Llp Treatment of irritable bowel syndrome using probiotic composition
US9084434B2 (en) 2006-09-27 2015-07-21 Little Calumet Holdings Llc Probiotic oral dosage forms
SG11201704543XA (en) 2014-12-05 2017-07-28 Synlogic Inc Bacteria engineered to treat diseases associated with hyperammonemia
JP7095993B2 (ja) 2015-03-02 2022-07-05 シンロジック オペレーティング カンパニー インコーポレイテッド 消化管炎症低下および／または消化管粘膜バリア強化の利益を享受する疾患処置のために操作された細菌
ES2881384T3 (es) * 2015-05-13 2021-11-29 Synlogic Operating Co Inc Bacterias manipuladas para reducir la hiperfenilalaninemia
WO2016200614A2 (en) 2015-06-10 2016-12-15 Synlogic, Inc. Bacteria engineered to treat diseases associated with hyperammonemia
AU2016276973B2 (en) 2015-06-10 2022-09-01 Synlogic Operating Company, Inc. Bacteria engineered to treat disorders involving the catabolism of a branched chain amino acid
WO2016210384A2 (en) 2015-06-25 2016-12-29 Synlogic, Inc. Bacteria engineered to treat metabolic diseases
US20170216370A1 (en) 2015-07-31 2017-08-03 Synlogic, Inc. Bacteria engineered to treat disorders involving propionate catabolism
US11273184B2 (en) 2015-08-31 2022-03-15 Synlogic Operating Company, Inc. Bacteria engineered to treat disorders in which oxalate is detrimental
EP3368696A1 (en) 2015-10-30 2018-09-05 Synlogic Operating Company, Inc. Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier
ES2925049T3 (es) 2015-11-16 2022-10-13 Synlogic Operating Co Inc Bacterias manipuladas para reducir la hiperfenilalaninemia
WO2017123676A1 (en) 2016-01-11 2017-07-20 Synlogic, Inc. Recombinant bacteria engineered to treat diseases and disorders associated with amino acid metabolism and methods of use thereof
WO2017123418A1 (en) 2016-01-11 2017-07-20 Synlogic, Inc. Bacteria engineered to treat metabolic diseases
EP3411051A2 (en) 2016-02-04 2018-12-12 Synlogic Operating Company, Inc. Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier
WO2017136795A1 (en) 2016-02-04 2017-08-10 Synlogic, Inc. Bacteria engineered to treat diseases associated with tryptophan metabolism
WO2017139697A1 (en) 2016-02-10 2017-08-17 Synlogic, Inc. Bacteria engineered to treat diseases associated with hyperammonemia
BR112019013863A2 (pt) 2017-01-06 2020-03-03 Synlogic Operating Company, Inc. Micro-organismos programados para produzir moduladores imunes e terapêuticos anticâncer em células tumorais
CN111655841A (zh) 2017-06-21 2020-09-11 同生运营公司 用于治疗紊乱的细菌
JP2020527025A (ja) 2017-07-12 2020-09-03 シンロジック オペレーティング カンパニー インコーポレイテッド 腫瘍細胞において免疫モジュレーターおよび抗がん治療剤を産生するようにプログラムされた微生物

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