KR20210076048A - 조혈 줄기 및 전구 세포 확장 시스템 - Google Patents

조혈 줄기 및 전구 세포 확장 시스템 Download PDF

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KR20210076048A
KR20210076048A KR1020217013899A KR20217013899A KR20210076048A KR 20210076048 A KR20210076048 A KR 20210076048A KR 1020217013899 A KR1020217013899 A KR 1020217013899A KR 20217013899 A KR20217013899 A KR 20217013899A KR 20210076048 A KR20210076048 A KR 20210076048A
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medium
inhibitor
acid
supplement
salts
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Korean (ko)
Inventor
자넷 세이
아비게일 베커
나브조트 카우어
모한 베무리
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라이프 테크놀로지스 코포레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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    • C12N2500/05—Inorganic components
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    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
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    • C12N2500/99—Serum-free medium
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/065—Modulators of histone acetylation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2303—Interleukin-3 (IL-3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2306—Interleukin-6 (IL-6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Biotechnology (AREA)
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  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020217013899A 2018-10-12 2019-10-14 조혈 줄기 및 전구 세포 확장 시스템 Ceased KR20210076048A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862745208P 2018-10-12 2018-10-12
US62/745,208 2018-10-12
US201962854250P 2019-05-29 2019-05-29
US62/854,250 2019-05-29
PCT/US2019/056145 WO2020077343A1 (en) 2018-10-12 2019-10-14 Hematopoietic stem and progenitor cell expansion system

Publications (1)

Publication Number Publication Date
KR20210076048A true KR20210076048A (ko) 2021-06-23

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KR1020217013899A Ceased KR20210076048A (ko) 2018-10-12 2019-10-14 조혈 줄기 및 전구 세포 확장 시스템

Country Status (6)

Country Link
US (1) US20210386787A1 (https=)
EP (1) EP3863648A1 (https=)
JP (2) JP2022504722A (https=)
KR (1) KR20210076048A (https=)
CN (1) CN112805015A (https=)
WO (1) WO2020077343A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024539519A (ja) * 2021-10-20 2024-10-28 エクシール， インク． 非ヒト霊長類の個別化されたゲノムアセンブリ及び人工多能性幹細胞株を前臨床評価に使用するための組成物及び方法
CN114891749B (zh) * 2022-07-13 2022-12-02 杭州艾名医学科技有限公司 一种胰腺癌类器官的培养基及胰腺癌类器官的培养方法
CN115975929A (zh) * 2022-08-18 2023-04-18 南通大学 Kat2a抑制剂在治疗脊髓及坐骨神经损伤中的应用
CN115644066B (zh) * 2022-12-02 2024-01-16 福建农林大学 利用外源多胺提高龙眼胚性愈伤组织生长量和类黄酮含量的方法
LU507930B1 (en) * 2024-08-05 2026-02-05 Luxembourg Institute Of Science And Tech Serum-free culture medium for the culture of human monocytic cells and method using the same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1170008A1 (en) * 2000-07-07 2002-01-09 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Valproic acid and derivatives thereof as histone deacetylase inhibitors
JP2009509911A (ja) * 2005-05-05 2009-03-12 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ リンパ造血組織を定着させるためのｍａｐｃまたはそれらの子孫の使用
KR20110019727A (ko) * 2008-04-07 2011-02-28 뉴포텐셜, 인크. Ｒｎａ 간섭을 통한 다능 유전자의 유도에 의한 세포 재프로그래밍
JP5694946B2 (ja) * 2008-12-03 2015-04-01 インターナショナル ステム セル コーポレイション 幹細胞から分化細胞を得る方法
WO2010108126A2 (en) * 2009-03-19 2010-09-23 Fate Therapeutics, Inc. Reprogramming compositions and methods of using the same
WO2011158806A1 (ja) * 2010-06-14 2011-12-22 日産化学工業株式会社 造血幹細胞の製造方法
WO2011159684A2 (en) * 2010-06-15 2011-12-22 Cellular Dynamics International, Inc. Generation of induced pluripotent stem cells from small volumes of peripheral blood
ES2769270T3 (es) * 2011-09-30 2020-06-25 Bluebird Bio Inc Compuestos para transducción viral mejorada
WO2013086029A1 (en) * 2011-12-05 2013-06-13 Primorigen Biosciences Inc. Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
EP2982745A1 (en) * 2014-08-06 2016-02-10 Johann Wolfgang Goethe-Universität, Frankfurt am Main Method for expanding immune cells
US10669528B2 (en) * 2015-06-25 2020-06-02 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
EP4049665B1 (en) * 2016-03-15 2025-03-12 The Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion
WO2018160028A1 (ko) * 2017-03-02 2018-09-07 주식회사 셀라토즈테라퓨틱스 신경세포 분화용 배지 조성물 및 상기 배지 조성물을 이용한 체세포로부터 신경세포로의 분화 방법

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Publication number Publication date
EP3863648A1 (en) 2021-08-18
CN112805015A (zh) 2021-05-14
JP2024137954A (ja) 2024-10-07
JP2022504722A (ja) 2022-01-13
US20210386787A1 (en) 2021-12-16
WO2020077343A1 (en) 2020-04-16

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