KR20210018321A - 종양 특이적 신생항원 및 이를 사용하는 방법 - Google Patents

종양 특이적 신생항원 및 이를 사용하는 방법 Download PDF

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KR20210018321A
KR20210018321A KR1020207037379A KR20207037379A KR20210018321A KR 20210018321 A KR20210018321 A KR 20210018321A KR 1020207037379 A KR1020207037379 A KR 1020207037379A KR 20207037379 A KR20207037379 A KR 20207037379A KR 20210018321 A KR20210018321 A KR 20210018321A
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nucleic acid
cancer
subject
acid molecule
tumor
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Korean (ko)
Inventor
엘리자베스 케네디 듀퍼렛
알프레도 페랄레스 푸샬트
데이비드 위너
니란잔 와이. 사르데사이
Original Assignee
더 위스타 인스티튜트
지노스 세라퓨틱스, 인크.
이노비오 파마수티컬즈, 인크.
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/4201—Neoantigens
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020207037379A 2018-05-25 2019-05-28 종양 특이적 신생항원 및 이를 사용하는 방법 Pending KR20210018321A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862676563P 2018-05-25 2018-05-25
US62/676,563 2018-05-25
PCT/US2019/034229 WO2019227106A1 (en) 2018-05-25 2019-05-28 Tumor-specific neoantigens and methods of using the same

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KR20210018321A true KR20210018321A (ko) 2021-02-17

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KR1020207037379A Pending KR20210018321A (ko) 2018-05-25 2019-05-28 종양 특이적 신생항원 및 이를 사용하는 방법

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US (2) US12528848B2 (https=)
EP (1) EP3801597A4 (https=)
JP (2) JP2021525549A (https=)
KR (1) KR20210018321A (https=)
CN (1) CN112261947A (https=)
CA (1) CA3100974A1 (https=)
MX (1) MX2020012649A (https=)
WO (1) WO2019227106A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016341309A1 (en) 2015-10-22 2018-06-07 Modernatx, Inc. Cancer vaccines
IT201900016718A1 (it) * 2019-09-19 2021-03-19 Takis S R L Combinazione di agenti immunomodulatori con neoantigeni tumore-specifici per l’uso nella prevenzione e nel trattamento dei tumori.
CN112501201A (zh) * 2021-02-07 2021-03-16 无锡市人民医院 一种用于治疗非小细胞肺癌的rna疫苗及其构建方法
AU2023267771A1 (en) * 2022-05-10 2024-12-19 Geneos Therapeutics, Inc. Vaccines and methods of using the same to treat wnt-related cancer
KR20250024532A (ko) * 2022-05-10 2025-02-18 지노스 세라퓨틱스, 인크. 개인 맞춤형 암 에피토프 및 이의 사용 방법
WO2024102764A1 (en) * 2022-11-07 2024-05-16 The Wistar Institute Of Anatomy And Biology Compositions comprising neoantigens and methods of enhancing anti-pd1 therapy
CN116966105B (zh) * 2023-04-20 2025-12-19 合肥核信生物科技有限责任公司 促进皮肤细胞胶原蛋白生成的小分子及其应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8212000B2 (en) * 1970-02-11 2012-07-03 Immatics Biotechnologies Gmbh Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
US20110027310A1 (en) * 2007-05-04 2011-02-03 Medin Jeffrey A Compositions and Methods for Cancer Treatment
US20090041792A1 (en) * 2007-07-19 2009-02-12 Istituto Superiore Di Sanita Dendritic cells, uses therefor, and vaccines and methods comprising the same
EP2569633B1 (en) * 2010-05-14 2016-02-10 The General Hospital Corporation Compositions and methods of identifying tumor specific neoantigens
CN103068846B9 (zh) 2010-08-24 2016-09-28 弗·哈夫曼-拉罗切有限公司 包含二硫键稳定性Fv片段的双特异性抗体
PL3892295T3 (pl) 2011-05-24 2023-07-24 BioNTech SE Zindywidualizowane szczepionki przeciwnowotworowe
WO2012159643A1 (en) 2011-05-24 2012-11-29 Biontech Ag Individualized vaccines for cancer
CN103160473B (zh) * 2011-12-13 2014-08-20 北京微谷生物医药有限公司 用于拯救麻疹病毒的组合物、试剂盒、用途及方法
AU2013207669C1 (en) * 2012-01-13 2018-05-31 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
KR20150130284A (ko) * 2013-03-15 2015-11-23 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암 백신 및 이를 이용한 치료 방법
EP2983702A2 (en) 2013-04-07 2016-02-17 The Broad Institute, Inc. Compositions and methods for personalized neoplasia vaccines
JP6679484B2 (ja) * 2013-12-11 2020-04-15 ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド ヒトヘルペスウイルス三量体糖タンパク質Ｂ、三量体ｇＢを含むタンパク質複合体、及びワクチンとしてのそれらの使用
KR20230076867A (ko) * 2013-12-20 2023-05-31 더 브로드 인스티튜트, 인코퍼레이티드 신생항원 백신과의 병용 요법
WO2016040900A1 (en) 2014-09-14 2016-03-17 Washington University Personalized cancer vaccines and methods therefor
IL294183B2 (en) 2015-05-20 2023-10-01 Dana Farber Cancer Inst Inc shared neoantigens
MA42543A (fr) * 2015-07-30 2018-06-06 Modernatx Inc Arn épitope peptidiques concatémériques
SG11201803934YA (en) * 2015-11-11 2018-06-28 Intrexon Corp Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies
EP3400005A1 (en) * 2016-01-08 2018-11-14 Vaccibody AS Neoepitope rna cancer vaccine
WO2017139498A1 (en) * 2016-02-09 2017-08-17 Cour Pharmaceuticals Development Company Inc. Timps encapsulating japanese cedar pollen epitopes
WO2017152042A2 (en) 2016-03-04 2017-09-08 New York University Virus vectors expressing multiple epitopes of tumor associated antigens for inducing antitumor immunity
KR20180117227A (ko) * 2016-03-24 2018-10-26 난트셀, 인크. 네오에피토프 제시를 위한 시퀀스들 및 시퀀스 배열들
EP3452082A1 (en) * 2016-05-04 2019-03-13 Fred Hutchinson Cancer Research Center Cell-based neoantigen vaccines and uses thereof
US20190351040A1 (en) * 2017-02-01 2019-11-21 Modernatx, Inc. Rna cancer vaccines
EP3773649A4 (en) * 2018-03-28 2022-02-23 EpicentRx, Inc. PERSONALIZED CANCER VACCINE

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JP2021525549A (ja) 2021-09-27
US20210361755A1 (en) 2021-11-25
CA3100974A1 (en) 2020-11-28
EP3801597A1 (en) 2021-04-14
MX2020012649A (es) 2021-07-02
WO2019227106A1 (en) 2019-11-28
US12528848B2 (en) 2026-01-20
WO2019227106A9 (en) 2020-06-04
CN112261947A (zh) 2021-01-22
JP2024091964A (ja) 2024-07-05
US20260085100A1 (en) 2026-03-26
EP3801597A4 (en) 2022-05-04

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