JP2021525549A - 腫瘍特異的ネオ抗原およびその使用方法 - Google Patents

腫瘍特異的ネオ抗原およびその使用方法 Download PDF

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JP2021525549A
JP2021525549A JP2021516553A JP2021516553A JP2021525549A JP 2021525549 A JP2021525549 A JP 2021525549A JP 2021516553 A JP2021516553 A JP 2021516553A JP 2021516553 A JP2021516553 A JP 2021516553A JP 2021525549 A JP2021525549 A JP 2021525549A
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nucleic acid
cancer
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cells
acid molecule
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エリザベス ケネディ デュペレット，
エリザベス ケネディ デュペレット，
アルフレッド ペラレス プチャルト，
アルフレッド ペラレス プチャルト，
デイビッド ウェイナー，
デイビッド ウェイナー，
ニランジャン ワイ． サーデサイ，
ニランジャン ワイ． サーデサイ，
Original Assignee
ザ ウィスター インスティテュート
ザ ウィスター インスティテュート
イノビオ ファーマシューティカルズ， インコーポレイテッド
イノビオ ファーマシューティカルズ， インコーポレイテッド
ジェネオス セラピューティクス， インコーポレイテッド
ジェネオス セラピューティクス， インコーポレイテッド
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Publication of JP2021525549A publication Critical patent/JP2021525549A/ja
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JP2021516553A 2018-05-25 2019-05-28 腫瘍特異的ネオ抗原およびその使用方法 Pending JP2021525549A (ja)

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016341309A1 (en) 2015-10-22 2018-06-07 Modernatx, Inc. Cancer vaccines
IT201900016718A1 (it) * 2019-09-19 2021-03-19 Takis S R L Combinazione di agenti immunomodulatori con neoantigeni tumore-specifici per l’uso nella prevenzione e nel trattamento dei tumori.
CN112501201A (zh) * 2021-02-07 2021-03-16 无锡市人民医院 一种用于治疗非小细胞肺癌的rna疫苗及其构建方法
AU2023267771A1 (en) * 2022-05-10 2024-12-19 Geneos Therapeutics, Inc. Vaccines and methods of using the same to treat wnt-related cancer
KR20250024532A (ko) * 2022-05-10 2025-02-18 지노스 세라퓨틱스, 인크. 개인 맞춤형 암 에피토프 및 이의 사용 방법
WO2024102764A1 (en) * 2022-11-07 2024-05-16 The Wistar Institute Of Anatomy And Biology Compositions comprising neoantigens and methods of enhancing anti-pd1 therapy
CN116966105B (zh) * 2023-04-20 2025-12-19 合肥核信生物科技有限责任公司 促进皮肤细胞胶原蛋白生成的小分子及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013539463A (ja) * 2010-08-24 2013-10-24 エフ．ホフマン−ラ ロシュ アーゲー ジスルフィドによって安定化されたＦｖ断片を含む二重特異性抗体
JP2017500298A (ja) * 2013-12-11 2017-01-05 ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド ヒトヘルペスウイルス三量体糖タンパク質Ｂ、三量体ｇＢを含むタンパク質複合体、及びワクチンとしてのそれらの使用
WO2017118702A1 (en) * 2016-01-08 2017-07-13 Vaccibody As Neoepitope rna cancer vaccine
WO2017139498A1 (en) * 2016-02-09 2017-08-17 Cour Pharmaceuticals Development Company Inc. Timps encapsulating japanese cedar pollen epitopes
WO2017152042A2 (en) * 2016-03-04 2017-09-08 New York University Virus vectors expressing multiple epitopes of tumor associated antigens for inducing antitumor immunity

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8212000B2 (en) * 1970-02-11 2012-07-03 Immatics Biotechnologies Gmbh Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
US20110027310A1 (en) * 2007-05-04 2011-02-03 Medin Jeffrey A Compositions and Methods for Cancer Treatment
US20090041792A1 (en) * 2007-07-19 2009-02-12 Istituto Superiore Di Sanita Dendritic cells, uses therefor, and vaccines and methods comprising the same
EP2569633B1 (en) * 2010-05-14 2016-02-10 The General Hospital Corporation Compositions and methods of identifying tumor specific neoantigens
PL3892295T3 (pl) 2011-05-24 2023-07-24 BioNTech SE Zindywidualizowane szczepionki przeciwnowotworowe
WO2012159643A1 (en) 2011-05-24 2012-11-29 Biontech Ag Individualized vaccines for cancer
CN103160473B (zh) * 2011-12-13 2014-08-20 北京微谷生物医药有限公司 用于拯救麻疹病毒的组合物、试剂盒、用途及方法
AU2013207669C1 (en) * 2012-01-13 2018-05-31 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
KR20150130284A (ko) * 2013-03-15 2015-11-23 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암 백신 및 이를 이용한 치료 방법
EP2983702A2 (en) 2013-04-07 2016-02-17 The Broad Institute, Inc. Compositions and methods for personalized neoplasia vaccines
KR20230076867A (ko) * 2013-12-20 2023-05-31 더 브로드 인스티튜트, 인코퍼레이티드 신생항원 백신과의 병용 요법
WO2016040900A1 (en) 2014-09-14 2016-03-17 Washington University Personalized cancer vaccines and methods therefor
IL294183B2 (en) 2015-05-20 2023-10-01 Dana Farber Cancer Inst Inc shared neoantigens
MA42543A (fr) * 2015-07-30 2018-06-06 Modernatx Inc Arn épitope peptidiques concatémériques
SG11201803934YA (en) * 2015-11-11 2018-06-28 Intrexon Corp Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies
KR20180117227A (ko) * 2016-03-24 2018-10-26 난트셀, 인크. 네오에피토프 제시를 위한 시퀀스들 및 시퀀스 배열들
EP3452082A1 (en) * 2016-05-04 2019-03-13 Fred Hutchinson Cancer Research Center Cell-based neoantigen vaccines and uses thereof
US20190351040A1 (en) * 2017-02-01 2019-11-21 Modernatx, Inc. Rna cancer vaccines
EP3773649A4 (en) * 2018-03-28 2022-02-23 EpicentRx, Inc. PERSONALIZED CANCER VACCINE

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013539463A (ja) * 2010-08-24 2013-10-24 エフ．ホフマン−ラ ロシュ アーゲー ジスルフィドによって安定化されたＦｖ断片を含む二重特異性抗体
JP2017500298A (ja) * 2013-12-11 2017-01-05 ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド ヒトヘルペスウイルス三量体糖タンパク質Ｂ、三量体ｇＢを含むタンパク質複合体、及びワクチンとしてのそれらの使用
WO2017118702A1 (en) * 2016-01-08 2017-07-13 Vaccibody As Neoepitope rna cancer vaccine
WO2017139498A1 (en) * 2016-02-09 2017-08-17 Cour Pharmaceuticals Development Company Inc. Timps encapsulating japanese cedar pollen epitopes
WO2017152042A2 (en) * 2016-03-04 2017-09-08 New York University Virus vectors expressing multiple epitopes of tumor associated antigens for inducing antitumor immunity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AURISICCHIO L. ET AL.: "A novel minigene scaffold for therapeutic cancer vaccines", ONCOIMMUNOLOGY, 2014, VOL. 3, NO. 1, E27529, JPN6023022004, ISSN: 0005444307 *
SZYMCZAK AL. ET AL.: "Correction of multi-gene deficiency in vivo using a single ‘self-cleaving’ 2A peptide-based retrov", NATURE BIOTECHNOLOGY, JPN6023022003, ISSN: 0005444308 *

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