KR20210016431A - 암 치료용 키메라 항원 수용체 t 세포 (car-t) - Google Patents

암 치료용 키메라 항원 수용체 t 세포 (car-t) Download PDF

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KR20210016431A
KR20210016431A KR1020207037911A KR20207037911A KR20210016431A KR 20210016431 A KR20210016431 A KR 20210016431A KR 1020207037911 A KR1020207037911 A KR 1020207037911A KR 20207037911 A KR20207037911 A KR 20207037911A KR 20210016431 A KR20210016431 A KR 20210016431A
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매튜 쿠퍼
존 에프. 디페르시오
쥴리 오닐
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워싱턴 유니버시티
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    • C07K2319/00Fusion polypeptide
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KR1020207037911A 2018-05-31 2019-05-31 암 치료용 키메라 항원 수용체 t 세포 (car-t) KR20210016431A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862678878P 2018-05-31 2018-05-31
US62/678,878 2018-05-31
US201962799513P 2019-01-31 2019-01-31
US62/799,513 2019-01-31
PCT/US2019/035010 WO2019232444A1 (en) 2018-05-31 2019-05-31 Chimeric antigen receptor t cells (car-t) for the treatment of cancer

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KR20210016431A true KR20210016431A (ko) 2021-02-15

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US (1) US20200071397A1 (de)
EP (1) EP3802798A4 (de)
JP (1) JP2021525524A (de)
KR (1) KR20210016431A (de)
CN (1) CN112912493A (de)
AU (1) AU2019279021A1 (de)
CA (1) CA3101505A1 (de)
IL (1) IL279063A (de)
SG (1) SG11202011383VA (de)
WO (1) WO2019232444A1 (de)

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CN110616188B (zh) * 2018-06-20 2023-05-09 上海隆耀生物科技有限公司 一种通用型car-t细胞及其制备方法和应用
CN118184800A (zh) 2019-05-07 2024-06-14 亘喜生物科技(上海)有限公司 靶向bcma的工程化免疫细胞及其用途
US11434291B2 (en) 2019-05-14 2022-09-06 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
EP4028031A4 (de) * 2019-09-13 2023-09-06 Memorial Sloan Kettering Cancer Center Auf cd371 abzielende antigenerkennende rezeptoren und deren verwendungen
US12006366B2 (en) 2020-06-11 2024-06-11 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
CN113214396B (zh) * 2020-07-31 2022-04-19 北京市神经外科研究所 抗tim3的单链抗体及其在制备治疗肿瘤的药物中的用途
US20240041932A1 (en) * 2020-09-14 2024-02-08 Vor Biopharma Inc. Compositions and methods for cd5 modification
CA3199621A1 (en) * 2020-10-26 2022-05-05 Memorial Sloan-Kettering Cancer Center Cells with cd70 knockout and uses for immunotherapy
WO2022098756A1 (en) * 2020-11-03 2022-05-12 WUGEN, Inc. Chimeric antigen receptor cell therapy
TW202330594A (zh) * 2021-09-29 2023-08-01 美商莫德斯醫療公司 抗原結合多肽、抗原結合多肽複合物及其使用方法
CN114369622A (zh) * 2021-12-31 2022-04-19 西安桑尼赛尔生物医药有限公司 同时靶向cd7和cd19的双特异通用型car-t细胞及其制备方法
CN114317607A (zh) * 2021-12-31 2022-04-12 西安桑尼赛尔生物医药有限公司 融合一代靶向cd7 car和二代靶向bcma的双靶点通用car-t细胞及制备方法
WO2024019961A1 (en) * 2022-07-18 2024-01-25 Cargo Therapeutics, Inc. Cd2 recruiting chimeric antigen receptors and fusion proteins
CN116284435A (zh) * 2022-09-19 2023-06-23 卡瑞济(北京)生命科技有限公司 EGFRvIII嵌合抗原受体及其用途
WO2024097797A1 (en) * 2022-11-02 2024-05-10 Medisix Therapeutics, Inc. Blockade of cd3 expression and chimeric antigen receptors for immunotherapy
CN116514992B (zh) * 2022-11-07 2024-05-24 武汉波睿达生物科技有限公司 一种信号肽序列优化的靶向cd19的嵌合抗原受体及其应用
CN117866110B (zh) * 2023-12-27 2024-06-11 广东唯泰生物科技有限公司 一种靶向flt-3的第四代嵌合抗原受体及其应用

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WO2003051926A2 (en) * 2001-12-14 2003-06-26 Friedrich-Alexander-Universitaet Erlangen-Nuernberg Anti-cd7 immunotoxin as fusion protein
US20130280220A1 (en) * 2012-04-20 2013-10-24 Nabil Ahmed Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes
JP6879910B2 (ja) * 2014-10-31 2021-06-02 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Cart細胞における遺伝子発現の改変およびその使用
US20180371052A1 (en) * 2015-12-22 2018-12-27 Icell Gene Therapeutics Llc Chimeric antigen receptors and enhancement of anti-tumor activity
WO2018027036A1 (en) * 2016-08-03 2018-02-08 Dipersio John F Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
US20200109364A1 (en) * 2018-05-31 2020-04-09 Washington University Methods for genome-editing and activation of cells
US20200054675A1 (en) * 2018-06-01 2020-02-20 Washington University Suppression of cytokine release syndrome in chimeric antigen receptor cell therapy

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WO2019232444A1 (en) 2019-12-05
AU2019279021A1 (en) 2020-12-10
CN112912493A (zh) 2021-06-04
EP3802798A1 (de) 2021-04-14
SG11202011383VA (en) 2020-12-30
JP2021525524A (ja) 2021-09-27
US20200071397A1 (en) 2020-03-05
EP3802798A4 (de) 2022-05-11
IL279063A (en) 2021-01-31
CA3101505A1 (en) 2019-12-05

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