KR20210015827A - 바이오-기반 의약품 및 환자 순응도를 향상시키는 방법 - Google Patents
바이오-기반 의약품 및 환자 순응도를 향상시키는 방법 Download PDFInfo
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- KR20210015827A KR20210015827A KR1020207034546A KR20207034546A KR20210015827A KR 20210015827 A KR20210015827 A KR 20210015827A KR 1020207034546 A KR1020207034546 A KR 1020207034546A KR 20207034546 A KR20207034546 A KR 20207034546A KR 20210015827 A KR20210015827 A KR 20210015827A
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Abstract
질병을 치료하는데 사용되는 의약품은 일반적으로 화석 연료에서 유래된 출발 물질로부터 만들어지므로 본질적으로 14C를 포함하지 않는다. 본 발명에서, 의약품은 생물학적 공급원으로부터 부분적으로 또는 완전히 유래될 수 있으므로 약 1 조분의 1 (ppt)의 14C를 함유한다. 이들 화합물은 환자 순응도를 상당히 증가시키는 것으로 밝혀졌기 때문에 질병 치료에 우수한 것으로 확인되었다. 대사 산물을 추적하기 위해 부분적으로 또는 완전히 바이오-기반 약학적 활성 화합물을 사용하는 화합물 및 방법이 또한 개시된다.
Description
본 발명은 바이오-기반 의약품 및 환자 순응도를 향상시키는 방법에 관한 것이다.
최적의 효과를 내기 위해 대부분의 약물은 일정 기간 동안 예정된대로 사용되어야 한다. 사람들이 요법을 따르는지 여부를 “순응도(compliance)” 또는 동일하게 “준수(adherence)”라고 하며, 사람들이 요법을 따르거나 준수하지 않는 것은 중요한 문제로 알려져 있다.
일반적인 환자에 대하여 말하면서, 세 개의 이전 발행물을 참조하는 McElnay 등은 “Self-reported medication non-compliance in the elderly,” Eur. J. Clin Pharmacol (1997) 53: 171-178에서 “일반적으로 환자의 3 분의 1이 40%에서 80% 사이의 용량을 ‘부분적으로’준수한다는 것이 널리 받아 들여지고 있다; 1/3은 ‘만족스럽게’준수하고, 때로는 더 많이 복용하고, 때로는 처방된 양보다 적게 복용한다; 6 분의 1은 매우 다양한 간격으로 처방된 용량의 40% 미만을 복용한다; 반면 6 분의 1은 좋은 순응자들이다.”라고 언급한다.
이 문제를 고려할 때, 환자 순응도를 개선할 수 있는 새로운 해결책을 제공할 강력한 동기가 있다.
요약
알려진 구조에 근거하여 약학적 활성 화합물이 개시되었는데, 상기 구조는 구조 또는 선택된 모이어티(moiety)에서 14C 함량이 살아있는 유기체의 14C 함량과 1 조당 1 부분 정도 유사한 바이오매스(biomass)로부터 전체 혹은 부분적으로 유래된 것이다. 또한, 상기 기재된 바이오-기반 약학적 화합물 또는 조성물 중 하나 이상을 환자에게 투여(또는 처방)하는 단계를 포함하는 환자를 치료하는 방법이 개시된다. 바람직하게는, 환자가 약물 조성물의 바이오 기반성을 알고 있는 것이다. 개시된 화합물은 화석-기반 화합물에 존재하는 것보다 더 높은 비율의 바이오-기반 탄소(즉, 더 높은 14C / 12C 동위 원소 비율)를 갖는다.
한가지 측면에서, 본 발명은 적어도 일부가 바이오매스로부터 유래된 약학적 활성 화합물을 제공한다. 바이오매스로부터 적어도 일부가 유래된 약학적 활성 화합물은 표 1의 화합물 중 임의의 것일 수 있다; 특히 바람직한 예로 다음을 포함한다: 클로르헥시딘 (클로르헥사메드 포르테) {Chlorhexidine(chlorhexamed forte)}, 암브록솔 (뮤코솔반) {Ambroxol (mucosolvan)}, 세티리진 (헥살) {Cetirizine (Hexal)}, 비사코딜 (듀코락스) {Bisacodyl (Ducolax)}, 자일로메타졸린 (올린쓰) {Xylomethazoline (Olynth)}, 디클로페낙 (통증 및 염증성 질환 치료를 위해 이용)(포르테 볼타렌) {Diclofenac (forte voltaren)}, 클로트리마졸 (카네스텐) {Clotrimazole (canesten)}, 오메프라졸 (오메프 헥살) {Omeprazole (omep Hexal)}, 플루르비프로펜 (통증 및 관절염 치료를 위한) (도벤단) {(Flurbiprofen (Dobendan)}, 나프록센 (돌로민) {Naproxen (Dolormin)}, 독실아민 (호가) {Doxilamine (Hoggar)}, 로페라미드 (Loperamide), 이부프로펜 (Ibuprofen) 또는 란소프라졸(lansoprazole). 일부 바람직한 실시 양태에서, 약학적 활성 화합물은 다음 특징 중 하나 이상을 갖는다: 바이오매스로부터 유래된 하나 이상의 방향족기(aromatic group)를 포함한다; 활성 화합물의 모든 방향족기는 바이오매스로부터 유래된다; 모든 화합물은 바이오매스로부터 유래된다; 약학적 활성 화합물은 살아있는 유기체의 14C : 12C 동위 원소 비율과 유사한 14C : 12C 동위 원소 비율을 갖는다(대략 1 조당 1 부분); 화합물은 순수하거나 하나 이상의 약학적으로 허용되는 부형제와 같은 혼합물 및/또는 적어도 2 개의 약학적 활성 화합물을 포함하는 혼합물로 존재할 수 있다; 화합물은 적어도 10%, 적어도 40%, 또는 적어도 50%, 또는 적어도 70%, 또는 100%, 또는 10 내지 90%, 또는 40 내지 90%, 또는 50 내지 90 질량%의 바이오-기반 탄소(백분율은 달리 표시되지 않는 한 항상 질량이다)를 함유한다. 위에 열거된 특정 화합물은 합성에 대한 특징적인 탄소 비율에 의해 특징될 수 있다. 앞서 언급한 비율 중 하나의 바이오-기반 탄소는 식물(이는 원료 식물 재료(raw plant materials) 또는 “환경-친화적 재생 가능한 원료 식물 재료”라고도 할 수 있다)에서 유래된 것일 수 있다. 조성물은 정제(tablet), 시럽(syrup), 수액(IV bag) 또는 캡슐과 같은 의약품 전달 형태이다. 화합물은 약물 전달 형태로서 적어도 1 mg, 또는 적어도 5 mg, 또는 적어도 10 mg, 또는 적어도 40 mg의 활성 화합물을 포함하는 조성물에 있다; 상기 조성물은 적어도 1%, 2% 또는 적어도 10%, 또는 적어도 50%, 또는 적어도 80 질량%의 활성 화합물을 포함한다; 및 / 또는 상기 화합물 또는 조성물은 적어도 10%, 또는 적어도 30%, 또는 20 내지 67%, 또는 20 내지 58%, 또는 10 내지 37%, 또는 10 내지 28% 또는 20 내지 28%의 순응도 상승에 의해 특징될 수 있다.
대안적인 측면에서, 본 발명은 약학적 투여용법에 대한 환자의 순응도를 개선하는데 사용하기 위한 물질 X로서 설명될 수 있는데, 상기 물질 X는 클로르헥시딘 (클로르헥사메드 포르테), 암브록솔 (뮤코솔반), 세티리진 (헥살), 비사코딜 (듀코락스), 자일로메타졸린 (올린쓰), 디클로페낙 (통증 및 염증성 질환 치료를 위해 이용)(포르테 볼타렌), 클로트리마졸 (카네스텐), 오메프라졸 (오메프 헥살), 플루르비프로펜 (통증 및 관절염 치료를 위한) (도벤단), 나프록센 (돌로민), 독실아민 (호가), 로페라미드 및 이부프로펜 중 하나이고, 상기 물질 X는 적어도 10 질량%의 바이오-기반 탄소를 포함한다. 바람직하게는 적어도 40%, 또는 적어도 50%, 또는 적어도 70% 또는 100% 바이오 기반 탄소이다. 마찬가지로, 이 물질은 추가로, 위에 설명되거나 아래의 구체적인 설명 섹션의 특징들 중 하나 또는 임의의 조합을 가질 수 있다. 더 넓은 측면에서 상기 물질은 표 1의 화합물 중 하나일 수 있다.
또 다른 측면에서, 본 발명은 탄소 원자의 10 내지 90 질량%가 바이오-기반 인 약학적 활성 화합물을 제공한다. 화합물은 표 1에서 선택될 수 있다. 화합물은 클로르헥시딘 (클로르헥사메드 포르테), 암브록솔 (뮤코솔반), 세티리진 (헥살, 비사코딜 (듀코락스), 자일로메타졸린 (올린쓰), 디클로페낙 (포르테 볼타렌), 클로트리마졸 (카네스텐), 오메프라졸 (오메프 헥살), 플루르비프로펜 (도벤단), 나프록센 (돌로민), 독실아민 (호가), 로페라미드 및 이부프로펜이다. 바람직하게는, 활성 화합물에서 탄소의 적어도 40%, 또는 적어도 50% 또는 적어도 70%는 바이오-기반 탄소이다. 이 화합물은 기존의 비-바이오-기반 약물(non-bio-based drug)과 비교하여 14C 함유 화합물 또는 모이어티의 대사산물, 수송 및/또는 분포를 평가함으로써 약물의 대사를 연구하는데 사용할 수 있다.
본 발명은 또한 바이오매스로부터 적어도 일부가 유래되고, 상기 특징 중 하나 또는 임의의 조합을 갖는, 약학적 활성 화합물을 포함하는 조성물을, 이를 필요로 하는 환자에게 투여하는 단계로 구성되는 질병 상태를 치료하는 방법을 포함한다. 바람직한 실시 양태에서, 환자는 적어도 하나의 약학적 활성 화합물이 적어도 일부가 바이오매스로부터 유래된다는 것을 알고 있다. 바람직하게는, 화합물은 적어도 3 일, 또는 적어도 5 일, 또는 적어도 10 일, 또는 적어도 30 일, 일부 실시 양태에서 3 일 내지 30 일, 기간에 걸쳐 투여되는 (일부 바람직한 실시 양태에서, 자가 투여되는) 다중 투여량으로 구성되는 투여 용법으로 투여된다. 질병 상태를 치료하는 방법은 바람직하게는 통상적으로 유래된(즉, 화석 연료로부터 유래된) 의약품과 비교하여 환자 순응도를 개선한다.
관련된 측면에서, 본 발명은 투여 용법에서 적어도 일부가 바이오매스로부터 유래된 약학적 활성 화합물을 투여하는 단계를 포함하는, 약학적 투여 용법에 대한 환자 순응도를 개선하는 방법을 제공한다.
일부 측면에서, 본 발명은 질병 상태를 치료하기 위한 바이오매스로부터 적어도 일부가 유래된 약학적 활성 화합물을 제공한다: 감염 치료 또는 대사 추적을 위한 클로르헥시딘, 호흡기 질환 치료를 위한 암브록솔, 알레르기 증상 치료를 위한 세티리진, 변비 치료를 위한 비사 코딜 , 코 막힘 치료를 위한 자일로메타졸린, 통증 및 염증성 질환 치료를 위한 디클로페낙 , 진균 감염 치료를 위한 클로트리마졸, 위궤양 및 위산 역류 치료를 위한 오메프라졸, 통증 및 관절염 치료를 위한 플루르비프로펜, 발열 및 통증 치료를 위한 나프록센, 알레르기 증상 치료를 위한 독실아민, 설사 치료를 위한 로페라미드, 열과 통증 치료를 위한 이부프로펜, 위궤양, 손상된 식도, 위식도 역류 질환 (GERD) 또는 높은 위산 수치 치료를 위한 란소프라졸, 저혈압 치료를 위한 메펜터민(mephentermine).
또 다른 측면에서, 약학적 활성 화합물은 통상적인 비-생물-기반 약물과 비교하여 14C 함유 화합물 또는 모이어티의 대사산물, 수송 및/또는 분포를 평가함으로써 약물의 대사를 연구하는데 사용된다. 본 발명은 (i) 적어도 일부가 바이오매스로부터 유래된 약학적 활성 화합물을 환자 집단의 환자에게 투여하는 단계 및 (ii) 약학적 활성 화합물의 적어도 하나의 대사 산물의 동위 원소 비율을 평가하는 단계를 포함하여, 환자 집단에서 약학적 활성 화합물의 대사를 평가하는 방법을 제공한다.
추가 측면에서, 본 발명은 바이오매스-기반 방향족을 다른 유기 분자와 반응시켜 적어도 일부가 바이오매스-기반 약학적 활성 분자를 생성하는 것을 포함하는 바이오매스-기반 약학적 활성 화합물의 제조 방법을 제공한다.
여기에 개시된 화합물, 조성물 및 방법은 약물 제품에 대한 증가된 환자 수용(patient acceptance) 및 환자 순응도를 포함하여 당업계에 특정한 장점을 제공한다. 의약품 또는 이를 구성하는 약학적 활성 화합물이 바이오매스, 바람직하게는 식물(목재, 콤 스토 버, 사탕 수수 사탕 수수, 기타 농업 자원을 포함하되 이에 제한되지 않음)과 같은 천연 공급 원료에서 공급된다는 환자 지식이 환자의 순응도를 향상시킨다는 점은 개시된 화합물, 조성물 및 방법의 유용한 점이다. 바이오-기반 치료에 대한 환자의 신뢰도가 높아짐에 따라, 개시된 화합물, 조성물 및 방법은 환자 순응도를 높이고(특정한 경우에 더 나은 효과와 증상 재발 감소) 환자 결과를 개선한다.
개시된 화합물, 조성물 및 방법의 추가적이고 뚜렷한 장점은 개시된 바이오-기반 화합물 중 임의의 것이 방사성 표지 연구(radio-labeled studies)에 사용될 수 있다는 것이다. 예를 들어, 이러한 연구는 약학적 활성 화합물 및 의약품의 대사 연구에 유용하다. 14C 대사 산물 및 모이어티는 이들이 살아있는 유기체와 상호 작용할 때 이동 및/또는 변화하면서 추적될 수 있다. 일부가 바이오-기반인 약학적 활성 화합물은 화합물이 생물학적 시스템에서 상호 작용하고 대사되기 때문에 모이어티를 추적하는 데 특히 유용할 수 있다. 약물 구조는 완전히 바이오-기반이거나 일부(일반적으로 아릴기(ary group)(들))만이 바이오-기반인 오직 일부 바이오-기반이기 때문에 다른 대사 산물이 서로 다른 14C/12C 비율을 갖는다.
용어설명:
방향족 - 여기서 사용된 용어 “방향족”또는“방향족 화합물”은 탄화수소 화합물 또는 하나 이상의 방향족기를 포함하는 화합물, 예를 들어 단일 방향족 고리 시스템(single aromatic ring systems) (예 : 벤질, 페닐 등) 및 융합된 다환 방향족 고리 시스템(fused polycyclic aromatic ring systems) (예 : 나프틸(naphthyl), 1,2,3,4- 테트라하이드로나프틸 등),을 지칭하는데 사용된다. 방향족 화합물의 예는 벤젠 (benzene), 톨루엔 (toluene), 인단 (indane), 인덴 (indene), 2-에틸 톨루엔 (2-ethyl toluene), 3-에틸 톨루엔, 4-에틸 톨루엔, 트리메틸 벤젠(trimethyl benzene) (예 : 1,3,5-트리메틸 벤젠, 1,2,4-트리메틸 벤젠, 1,2,3-트리메틸 벤젠 등), 에틸벤젠 (ethylbenzene), 스티렌 (styrene), 쿠멘 (cumene), 메틸벤젠 (methylbenzene), 프로필벤젠(propylbenzene), 자일렌 (xylenes) (예 : p-자일렌, m-자일렌, o-자일렌), 나프탈렌 (naphthalene), 메틸-나프탈렌 (예 : 1-메틸 나프탈렌), 안트라센 (anthracene), 9.10-디메틸 안트라센, 피렌 (pyrene), 페난트렌 (phenanthrene), 디메틸-나프탈렌 (예 : 1,5- 디메틸 나프탈렌, 1,6- 디메틸 나프탈렌, 2,5- 디메틸 나프탈렌 등), 에틸-나프탈렌, 히드린덴(hydrindene), 메틸-히드린덴 및 디메틸 히드린덴을 포함하나 이에 한정되지는 않는다. 단일-고리 및/또는 더 높은 고리 방향족이 또한 일부 실시 양태에서 생성될 수 있다. 방향족은 또한 헤테로원자 치환체(heteroatom substituents), 즉 페놀 (phenol), 크레졸 (cresol), 벤조푸란 (benzofuran), 아닐린 (aniline), 인돌 (indole) 등을 포함하는 단일 및 다중 고리 화합물도 포함한다.
바이오매스 - 여기서 사용되는 용어 “바이오매스”는 당업계에서 통상적인 의미를 말하며 재생 가능한 임의의 유기 에너지원 또는 화학 물질을 지칭하는데 사용된다. 이의 주요 구성 요소는 다음과 같다: (1) 나무(목재) 및 기타 모든 초목; (2) 농산물 및 폐기물 (옥수수, 과일, 엔실레지 쓰레기(garbage ensilage) 등); (3) 조류 및 기타 해양 식물; (4) 대사성 폐기물 (분뇨, 하수) 및 (5) 셀룰로오스 도시 폐기물. 예를 들어, 바이오매스 물질의 예는 “Huber, G.W. et al, “Synthesis of Transportation Fuels from Biomass: Chemistry, Catalysts, and Engineering,” Chem. Rev. 106, (2006), pp. 4044-4098.”에 기술되어 있다.
바이오매스는 살아있는 것이면서 최근 연료로서 사용이나 산업 생산을 위해 전환될 수 있는 죽은 생물학적 물질로 정의되었다. 바이오매스로서의 기준은 재료가 최근에 탄소 순환에 참여함으로써 연소 과정에서의 탄소 방출이 합리적으로 짧은 기간 동안 평균 순증가를 일으키지 않도록 하는 것이다 (이러한 이유로 토탄(peat), 갈탄(lignite) 및 석탄(coal)과 같은 화석 연료는 오랫동안 탄소 순환에 참여하지 않은 탄소를 포함하고 있어 연소 결과 대기 중 이산화탄소의 순증가가 발생하므로 이 정의에서 바이오 매스로 간주되지 않는다). 가장 일반적으로 바이오매스는 바이오연료로 사용하기 위해 재배한 식물 물질을 의미하지만, 섬유, 화학 물질 또는 열 생산에 사용되는 식물 또는 동물 물질도 포함한다. 바이오매스는 또한 생분해성 폐기물, 또는 도시 폐기물, 녹색 폐기물(잔디 또는 꽃베기나 울타리 다듬기와 같은 정원 또는 공원 폐기물로 구성된 생분해 성 폐기물)과 같이 연료로 태우거나 화학 물질로 전환될 수 있는 부산물, 가축 분뇨, 식품 가공 폐기물, 하수 슬러지, 목재 펄프 또는 조류의 흑액을 포함한 농업 부산물을 포함할 수 있다. 바이오 매스는 지질학적 과정에 의해 석탄, 오일 셰일 또는 석유와 같은 물질로 전환된 유기물질을 제외한다. 바이오매스는 모두 잠재적으로 유용한 뿌리, 줄기, 잎, 종자 껍질 및 과일과 함께 억새(miscanthus), 대극(spurge), 해바라기, 지팽이풀(switchgrass), 대마, 콘(옥수수), 포플러(poplar), 버드나무(willow), 사탕수수(sugarcane) 및 기름야자(야자유)를 포함한 식물로부터 광범위하고 일반적으로 재배된다. 바이오매스는 화석 연료에서 발견되는 양보다 훨씬 많은 양의 14C가 존재한다는 점에서 화석 유래 탄소와 구별될 수 있다.
“바이오기반”이란 약물 구조의 탄소 또는 약물 구조의 선택된 부분이 구조 또는 선택된 모이어티에서의 14C 함량이 1조당 1부분 정도로 살아있는 유기체의 14C 함량과 유사한 바이오 매스에서 유래된 것을 의미한다. 14C 함량은 방사선 계수 또는 가속기 질량 분석법으로 측정할 수 있다.
촉매 열분해는 탄화수소 물질을 촉매 존재하에서 급속 가열하여 화학 물질, 연료, 또는 화학 물질 및 연료로 전환하는 공정을 말한다. CFP에 적합한 장치 및 공정 조건의 예는 Huber 등의 미국특허 No 8,277,643, 및 9,169,442 그리고 Huber 등의 미국특허출원 2013/0060070 A1에 설명되어 있으며, 이는 본 명세서에 참고문헌으로 포함된다. 바이오 매스의 촉매 열분해를 위한 조건은 다음 특징 중 하나 또는 임의의 조합을 포함할 수 있다 (이는 본 발명의 더 넓은 측면을 제한하도록 의도한 것은 아님) : 제올라이트 촉매, ZSM-5 촉매; 다음 금속 중 하나 이상을 포함하는 제올라이트 촉매 : 티타늄, 바나듐, 크롬, 망간, 철, 코발트, 니켈, 구리, 아연, 갈륨, 백금, 팔라듐, 은, 인, 나트륨, 칼륨, 마그네슘, 칼슘, 텅스텐, 지르코늄, 세륨, 란타늄, 및 이들의 조합; 유동층, 순환층 또는 상승 반응기; 300 ~ 1000℃ 범위의 작동 온도; 및/또는 0.1 내지 40 사이의 고체 촉매 대 바이오매스 질량비.
“순응도(Compliance)”는 “준수(adherence)”로도 알려진 널리 알려진 용어이며, 환자가 투여용법을 따르는 정도를 의미한다. 이는 환자가 치료과정에서 처방된 양의 의약품을 처방된 시간 간격 동안 지속적으로 투여하는 정도와 동일하다. 여기서 “처방된”이란 의료 전문가(일반적으로 의사 또는 간호사)의 처방 또는 처방전 없이 구입할 수 있는 약품에 대해 라벨된 지침을 의미할 수 있다. 많은 약물 용법에 대한 환자의 순응도는 열악한 것으로 알려져 있으며, 심지어 생명을 위협하는 질병 치료용 의약품의 경우에도 환자 순응도는 50%까지 낮다. 순응도는, 예를 들어 환자들에게 그들의 투여에 대해 질문하거나, 소변이나 혈액을 검사하는 것과 같은 일반적인 방법으로 측정할 수 있다. 본 발명의 목적을 위해, 순응도는 예정된 환자에게 주어진 상황에서 그들의 순응도에 대해 질문하거나, 사람들, 바람직하게는 약의 사용자에게 주어진 상황에서 일반적으로 사용자의 순응도에 대해 질문함으로써 측정될 수도 있다. 일부 실시 양태에서, 순응도의 변화는, 예를 들어, 투여 용법에 순응할 가능성이 더 높고 훨씬 더 높은 카테고리를 추가하거나, 가능성이 낮고 훨씬 더 낮은 카테고리를 제거함으로써 계산될 수도 있다 (도 2 참조).
투여 용법은 투여 사이의 시간, 치료 기간 및 매번 복용해야 하는 양을 포함하는 약의 투약 일정이다. 투여용법에는 약을 복용하는 방법과 제형(투여 형태)도 포함된다. 이것은 일반적인 정의이며 최소한 2016년부터 유럽의 환자 아카데미(European’s Patient Academy)에서 찾은 정의이다.
표준 특허 용어와 마찬가지로, “본질적으로 구성되는(consisting essentially of)”이라는 용어는 방법에 실질적으로 영향을 미치는 추가 단계 또는 제품에 실질적으로 영향을 미치는 구성 요소의 존재를 배제한다. 일반적으로, 용어 “포함하는”을 사용하여 정의된 임의의 본 발명의 방법 또는 물건은 제한적인 용어 “본질적으로 구성되는” 또는 가장 좁은 경우 “구성되는”을 사용하여 특징될 수도 있다.
도 1은 소비자가 바이오-기반 의약품을 구매하게 만드는 제품 내 식물성(plant-based) 성분의 비율을 나타내는 소비자 비율을 보여주는 설문 조사 데이터를 요약한 그래프이다.
도 2는 독일, 스웨덴 및 영국 소비자에 의해 예상되는 바이오-기반 세티리진의 순응도 증가를 보여준다.
도 3은 기존의 이부프로펜과 비교하여 독일 소비자에 의해 기대되는 바이오-기반 이부프로펜의 순응도 증가를 보여준다.
도 2는 독일, 스웨덴 및 영국 소비자에 의해 예상되는 바이오-기반 세티리진의 순응도 증가를 보여준다.
도 3은 기존의 이부프로펜과 비교하여 독일 소비자에 의해 기대되는 바이오-기반 이부프로펜의 순응도 증가를 보여준다.
본 발명에서, 바이오-기반 의약품은 재생 가능한 소스(화석 연료가 아닌)로부터 공급되는 출발 물질로부터 합성된다. 재생 가능한 소스에서 바이오-기반 재료를 만드는 방법을 설명하는 특허와 논문은 많다. 본 발명에 따른 약학적 조성물을 제조하기 위한 바람직한 출발 물질은 상기 인용된 Huber 특허에 기술된 바와 같이 바이오매스의 열분해에 의해 제조된 방향족 생성물이다. 또 다른 예를 언급하기 위해 Miller 등 미국특허 No. 9,668,951 (아래에서 전체적으로 재현된 것처럼 여기에 통합됨)에서는 미생물 공정에서 바이오-기반 1,3-프로판디올을 만드는 방법을 설명한다. Cukalovic은“Use of microreactor technology and renewable resources to develop green chemical processes,” Ph.D. dissertation, Ghent University, (2012)에서 6-치환 3-피리디놀로 전환될 수 있는 (5-알킬아미노메틸-2-히드록스메틸) 푸란 구조를 생성하는 히드록시메틸푸란 (HMF)의 환원적 아민화가 감각 연구에 유용하거나 다양한 제약 또는 농약으로 추가 전환을 위한 출발 물질에 유용하다는 것을 기술한다 (Kohl et al, “The Selection of Pantoprazole as a clinical Candidate,” J. Med. Chem. (1992), vol. 35, Issue 6, pages 1049-1057 참조). Tsolakis 등은 Mapping supply dynamics in renewable feedstock enabled industries: A systems theory perspective on “green” pharmaceuticals, Operations Management Research (2018), Vol. 11, pages 83-104에서 파라세타몰(paracetamol)의 경우 활성 약학 성분 (API)이 리모넨(limonene) 또는 β-피넨(β-pinene)과 같은 테르페노이드(terpenoid) 공급 원료로 제조될 수 있다고 보고한다. 감귤류 폐기물에서 의미있는 농도로 발견되는 리모넨, 또는 조 황산염 테레빈유(crude sulphate turpentine)에서 상당한 양으로 추출되는 β-피넨의 공급자의 식별은 크래프트 종이 및 펄프 산업에서 오는 쓰레기에 기반한다. 마흐무드는 The selective synthesis of aromatics and furans from biomass-derived compounds, Thesis, 2016, University of Delaware에서 푸란의 Diels-Alder 반응은 이러한 화합물의 방향족 분자로의 전환, 의약품 합성 및 기타 중요한 분자의 다양성에 대한 중요한 반응이라고 언급한다. 바이오기반 물질을 설명하는 다른 발행물은 다음을 포함한다: Xu et ah, Direct production of indoles via thermos-catalytic conversion of bio-derived furans with ammonia over zeolites, Green Chemistry (2015), Vol. 17, pages 1281-1290; Carlson et ah, Aromatic Production from Catalytic Fast Pyrolysis of Biomass-derived Feedstock, Topics in Catalysis (2004), vol. 52, pages 241-252.
바이오-기반 탄소에 대한 테스트 방법은 잘 알려져 있다. ASTM D6866 - 18, 방사성 탄소 분석을 사용하여 고체, 액체 및 기체 샘플의 바이오기반 함량을 결정하는 표준 테스트 방법은 밭에서 자연적인 생활을 하는 작물이나 풀을 수확하는 것과 같이 호흡 또는 물질대사가 중단되는 시간에 탄소원이 대기 중 CO2와 직접 평형을 이루고 있는 물질(materials)에 정확한 바이오기반/생체탄소 함량 결과를 제공한다. 액체 신틸레이션 카운팅은(Liquid Scintillation Counting)은 화합물에서 14C의 분포를 분석하는데 사용할 수 있는 오래된 기술이다; 예를 들어, Kent et a , “A Method for Obtaining the 14C-Isotope Distribution in Malate (C-2,3),” Anal. Biochem. 80, 176-182 (1977). 좀 더 최근에는 가속기 질량 분석법(accelerator mass spectrometry)을 사용하여 화합물에서 14C의 분포를 분석할 수 있다. 본 발명에서, 일부가 바이오-기반인 화합물은 약물의 대사 변환(metabolic transformations), 수송(transport) 및/또는 분포(distribution)를 연구하는데 사용될 수 있다. 이것은 인간 또는 비-인간 피험자에게 완전 바이오-기반 또는 ,우선적으로, 일부 바이오-기반 화합물을 투여함으로써 수행될 수 있다; 그런 다음 체내에서 또는 체내로부터 배출된 샘플을 수집한다. 일반적으로 샘플은 농축 (필요한 경우 여러 피험자로부터 수집 및 농축)되고 14C의 존재, 농도 및/또는 분포에 대해 분석된다. 원하는 경우 결과를 동일한 구조를 가진 기존의 비-바이오 기반 의약품과 비교할 수 있다.
본 발명의 일부 바람직한 실시 양태에서, 방향족 출발 물질은 바이오매스의 열분해 (바람직하게는 식물 물질의 열분해)에 의하여 제공된다; 예를 들어, Huber 등의 방법에 의해 여기에 통합된다. 따라서 바람직한 출발 물질은 바이오-기반 벤젠, 톨루엔 및 자일렌을 포함한다. 나프탈렌 및 티오펜(thiophene)과 같은 다른 방향족 출발 물질이 사용될 수 있으며 또한 바이오매스의 열분해로부터 유도될 수도 있다.
본 발명의 측면에서, 바이오-기반 또는 일부 바이오-기반 약학적 활성 화합물 또는 약학 조성물의 약학적 유효량이 제공된다. 일부 실시 양태에서, 용량은 표 1에 제시된 약학적 활성 화합물 중 어느 하나를 포함하는 약학 조성물을 포함한다. 조성물은 순수한 활성 성분일 수 있거나 불활성 및/또는 다른 약리학적 활성 화합물과의 혼합물일 수 있다. 화합물은 표 1에 기재된 화합물 중 어느 하나에서 선택 될 수 있다. 하나의 예를 제공하기 위해, 바이오-기반 또는 일부 바이오-기반 란소프라졸 분자의 약학적 유효 용량은 아래에 서술된다.
이 화합물은 완전히 바이오-기반이거나 오직 페닐 그룹 (피리딘 그룹이 아님)만이 바이오-기반일 수 있다; 또는 란소프라졸 구조에서 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 또는 적어도 90%, 또는 30% 내지 90%, 또는 30% 내지 80%, 또는 40% 내지 90%, 또는 50% 내지 100%의 탄소 원자가 바이오 기반이다. 이 화합물은 실질적으로 완전히 바이오-기반일 수 있다. 위 실시예에서 “란소프라졸”을 대체하는 표 1의 각각의 화합물이 한 번에 하나씩 고려된다.
따라서, 다른 예에서, 아래에 서술된 바와 같이, 바이오-기반 또는 일부 바이오-기반 세티리진의 약학적 유효 용량이 제공된다:
이 화합물은 완전히 바이오-기반이거나 오직 페닐 그룹만이 바이오-기반일 수 있다; 또는 세티리진 구조에서 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 또는 적어도 90%, 또는 30% 내지 90%, 또는 30% 내지 80%, 또는 40% 내지 90%, 또는 50% 내지 100%의 탄소 원자가 바이오 기반이다. 화합물은 실질적으로 완전히 바이오-기반일 수 있다.
위 실시예에서 “세티리진”을 대체하는 표 1의 각각의 화합물이 한 번에 하나씩 고려된다.
반응식 1. 세티리진 하이드로클로라이드(Cetrizine hydrochloride)의 합성
세티리진의 위의 합성으로부터, 본 발명은 탄소 원자 (아릴기의 탄소) 중 12/20이 바이오-기반인 세티리진을 제공한다는 것을 일부 바람직한 실시예에서 쉽게 알 수 있다, 또는 13/20 탄소 원자 (3차 탄소 포함). 비-방향족 바이오-기반 화합물의 사용을 통해 더 높은 비율이 제공될 수도 있다.
세티리진 디하이드로클로라이드에 대한 대안적인 접근법은 4-클로로벤질 클로라이드에서 시작된다(Guangdong Huagong, 2008, 35, 66-67) (반응식 2).
반응식 2. 세티리진 디하이드로클로라이드로의 4-클로로벤질 클로라이드 접근법
세티리진 디하이드로클로라이드에 대한 가장 일반적인 접근방식은 4-클로로 벤조페논(4-chlorobenzophenone) 또는 4-클로로벤즈히드롤(4-chlorobenzhydrol)을 포함하는 화학물질을 사용한다. 경로 선택은 아래에 있다 (반응식 3).
반응식 3. 세티리진 중간체로의 경로
Org & Biomolecular Chem, 2017, 15, 4984-91
Zhumal Organicheskoi Khimii, 1989, 25, 2372-4
Tetrahedron Lett, 1983, 24, 5181-4
Zhongguo Kexue Jishu Daxue Xuebao, 1993, 23, 359-1
Jingxi Huagong, 2014,31,68-1
Tetrahedron Lett, 1987, 28, 2053-6
Chemical Engineering Journal, 2018, 331, 443-9
위의 화학반응에 사용된 기본 화학물질은 벤젠 또는 톨루엔에서 공급될 수 있다 - 예는 반응식 4에 나와 있다.
반응식 4. 벤젠 또는 톨루엔에서 파생된 중간체의 예
클로르헥시딘(클로헥사메드 포르테)의 합성
클로르헥시딘의 위의 합성으로부터, 일부 바람직한 실시 양태에서, 본 발명은 탄소 원자 (아릴기의 탄소)의 12/22가 바이오-기반인 클로르헥시딘을 제공함을 알 수 있다. 또는 바이오-기반 알킬아민이 사용될 경우 더 높다.
벤젠으로부터 4-클로로아닐린 중간체 :
암브록솔(뮤코솔반)의 합성
반응식 1. (CN 104788326 A)
톨루엔으로부터 2-니트로벤즈알데히드 중간체:
단계 1: Gerald Booth (2007). “Nitro Compounds, Aromatic”. Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH.
단계 2: Lauth, Bull. Soc. Chim. France, (3) 31, 133 (1904)
암브록솔의 위의 합성으로부터, 일부 바람직한 실시 양태에서, 본 발명은 탄소 원자 (톨루엔기의 탄소)의 7/13이 바이오-기반인 암브록솔을 제공함을 알 수 있다. 또는 바이오-기반 비방향족 출발물질이 사용될 경우 더 높다.
비사코딜(듀코락스)의 합성
반응식 1. Kottler 등 미국특허 2,764,590 Certain 4, 4'-disubstituted-diphenylpyridyl methanes and process
비사코딜의 위의 합성으로부터, 일부 바람직한 실시 양태에서, 본 발명은 탄소 원자 (아릴 기의 탄소)의 12/22가 바이오-기반인 클로르헥시딜을 제공함을 알 수 있다. 또는 바이오-기반 아세트산무수물이 이용하는 경우 16/22.
톨루엔으로부터 페놀 중간체
반응식 2. W. W. Kaeding et al. Ind. Eng. Chem. Process Des. Dev., 1965, 4 (1), pp 97-101, “Oxidation of Toluene and Other Alkylated Aromatic Hydrocarbons to Benzoic Acids and Phenols.”
자일로메타졸린 (올린쓰)의 합성
반응식 1. Hueni 미국특허 2,868,802 A 2-(y-Tert-butyl-o,o'-dimethyl-phenyl-methyl)-imidazoline and salts.
m-자일렌으로부터 파라-터셔리-부틸-오르쏘:오르쏘'-디메틸-페닐-아세토니트릴(para-tertiary-butyl-ortho:ortho'-dimethyl-phenyl-acetonitrile) 중간체
반응식 2.
단계 1: Mohammad Ismail et ah, Journal of Scientific & Industrial Research, Vol. 67, May 2008, pp 371-373, “Reaction of xylenes with tert-butylchloride in presence of anhydrous aluminium chloride.”
단계 2: Buu-Hoi and P. Cagniant, Bulletin de la Societe Chimique de France, 1942, vol.9, p.889
자일로메타졸린의 위의 합성으로부터, 일부 바람직한 실시 양태에서, 탄소 원자 (자일렌으로부터의 탄소)의 8/14가 바이오-기반인 자일로메타졸린을 제공함을 알 수 있다. 또는 바이오-기반 알킬아민을 포함하는 경우 10/14.
디클로페낙(포르테 볼타렌)의 합성
반응식 1. Journal of the Indian Chemical Society, Vol. 83, No. 8 p. 838 - 841
디클로페낙의 합성으로부터, 일부 바람직한 실시 양태에서, 본 발명은 탄소 원자 (벤젠과 톨루엔으로부터의 탄소)의 13/14가 바이오-기반인 디클로페낙을 제공함을 알 수 있다. 또는 바이오-기반 화합물을 포함하여 카르복실산기를 생성하는 경우 14/14.
중간체:
벤젠으로부터 2,6-디클로로아닐린
반응식 2.
단계 1: U. Beck, E. Loser, “Chlorinated Benzenes and other Nucleus-Chlorinated Aromatic Hydrocarbons” Ullmann's Encyclopedia of Industrial Chemistry, 2012, Wiley-VCH, Weinheim.
단계 2: Gerald Booth (2007). “Nitro Compounds, Aromatic”, Ullmann's Encyclopedia of Industrial Chemistry, 2012, Wiley-VCH, Weinheim.
단계 3: Rylander, P.N. Hydrogenation Methods, Academic Press, NY, 1985, pp. 104-116.
톨루엔으로부터 2-클로로페닐아세트산
반응식 3.
단계 1: Petroleum Chemistry, Vol. 39, No. 3 p. 188-190
단계 2: Kajigaeshi, Shoji et al. Tetrahedron Letters, 1988 , Vol. 29, No. 45 p. 5783 - 5786
단계 3: Journal of Organic Chemistry, Vol. 39, p. 2420 - 2424
클로트리마졸(카네스텐)의 합성
반응식 1. Arzneimittel-Forschung/Drug Research, Vol. 42, No. 6, p. 832 - 835
클로트리마졸의 합성으로부터, 일부 바람직한 실시 양태에서 본 발명은 탄소 원자의 17/20이 바이오-기반인 클로트리마졸을 제공함을 알 수 있다.
톨루엔으로부터 중간체 2-클로로벤조트리클로라이드
반응식 2.
단계 1: Justus Liebigs Annalen der Chemie, Vol. 146, p. 322-331
단계 2: Justus Liebigs Annalen der Chemie, Vol. 493, p. 153,156,164
오메프라졸(오메프 헥살)의 합성
반응식 1. Nicolau et al. 유럽특허 1992619 Al Process for preparing 2-(2-pyridylmethyl)-sulfinyl-lH-benzimidazoles and the intermediate compounds used therein.
중간체:
(Z)-3-아미노-2-메틸-2-부텐산 에틸 에스테르 및 디에틸 메틸말로네이트로부터의 4-메톡시-2,3,5-트리메틸피리딘
반응식 2.
단계 1-3: Mittelbach, et al. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , Vol. 42, No. 8 p. 524 - 529
오메프라졸의 위의 합성으로부터, 일부 바람직한 실시 양태에서, 본 발명은 탄소 원자의 6/17이 바이오-기반인 오메프라졸을 제공함을 알 수 있다; 더 높은 농도의 바이오-기반 탄소 원자는 바이오-기반 비방향족 화합물에서 얻을 수 있다.
반응식 3.
벤젠으로부터의 (-)-메틸 5-메톡시-2-벤즈이미다졸릴설피네이트((-)-menthyl 5-methoxy-2-benzimidazolylsulphinate)
단계 1: Justus Liebigs Annalen der Chemie, Vol. 164, p. 162,176.
단계 2: Fujimoto et al. Tetrahedron, 1996 , Vol. 52, No. 1 1 p. 3889 - 3896
단계 3: Derkacheva et al. J . Gen. Chem. USSR (Engl. Transl.), 1981 , vol. 51, No. 10 p. 2319-2324.
단계 4: Liao et al. Journal of Organic Chemistry, 2012 , Vol. 77, No. 15 p. 6653 - 6656
단계 5: Uchida et al. Chemical and Pharmaceutical Bulletin, 1989 , Vol. 37, No. 6 p. 1517 - 1523
단계 6 & 7: Nicolau 등 유럽특허 1992619 Al Process for preparing 2-(2-pyridylmethyl)-sulfinyl-lH-benzimidazoles and the intermediate compounds used therein.
플루르비프로펜 (도벤단)의 합성
반응식 1 : Quasdorf, Kyle W. et al. Journal of the American Chemical Society, 2009, Vol. 131, No. 49 p. 17748 - 17749.
플루르비프로펜의 위의 합성으로부터, 일부 바람직한 실시 양태에서, 본 발명은 탄소 원자의 6/15가 바이오-기반 (페닐보론산의 아릴기로부터) 인 플루르비프로펜을 제공함을 알 수 있다; 또는 두 아릴기가 모두 바이오-기반인 경우 12/15.
벤젠으로부터 페닐보론산 중간체
반응식 2.
단계 1: Justus Liebigs Annalen der Chemie, Vol. 164, p. 162,176.
단계 2: Robertson, D. L. (2007-01-03). “Grignard Synthesis: Synthesis of Benzoic Acid and of Triphenylmethanol”
단계 3: Washburn, RM; Levens, E; Albright, CF; Billig, FA (1963). “Benzeneboronic anhydride” . Organic Syntheses.; Collective Volume, 4, p. 68
나프록센(돌로민)의 합성
단계 1. Harrison; Lewis; Nelson; Rooks; Roszkowski; Tomolonis; Fried Journal of medicinal chemistry, 1970, Vol. 13, No. 2, pp. 203-205.
나프탈렌으로부터의 6-메톡시-2-나프틸아세트산 중간체
반응식 2.
단계 1: Gerald Booth (2005), “Naphthalene Derivatives”, Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH.
단계 2: Org. Synth. 1940, 20, 18.
단계 3: Arakawa et al. Journal of Materials Chemistry, 2012, Vol. 22, No. 28 p. 13908 -13910.
단계 4 : Wu et al. Journal of the American Chemical Society, 2005, Vol. 127, No. 45 p. 15824-15832.
단계 5: Chemical Communications, Vol. 46, No. 10, p. 1697-
나프록센의 위의 합성으로부터, 일부 바람직한 실시 양태에서, 본 발명은 탄소 원자의 10/14가 바이오-기반 (나프탈렌으로부터) 인 나프록센을 제공함을 알 수있다. 또는 바이오-기반 시약의 사용을 통해 11/14 또는 14/14.
독실아민(호가)의 합성
반응식 1.
- 벤젠으로부터
단계 1: Justus Liebigs Annalen der Chemie, Vol. 164, p. 162,176.
단계 2-4: Nilesh et ah, World J . Pharm. Sci. 2016, 4(3), 478-481, efficient and safe process for synthesis of doxylamine succinate.”
독실아민의 위의 합성으로부터, 일부 바람직한 실시 양태에서, 본 발명은 탄소 원자의 6/17이 바이오-기반 (벤젠으로부터) 인 독실아민을 제공함을 알 수 있다; 또는 바이오-기반 시약을 사용하여 10/17 이상.
로페라미드의 합성
반응식 1. Chen, Zhengming et al. Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 2 1 p. 5275-5279.
벤젠으로부터 (3,3-디페닐옥솔란-2일리딘)-디메틸아자늄, 브롬화물 중간체
로페라미드의 위의 합성으로부터, 일부 바람직한 실시 양태에서, 본 발명은 탄소 원자의 18/29가 바이오-기반 (아릴 그룹으로부터) 인 로페라미드를 제공함을 알 수 있다; 또는 바이오-기반 시약의 사용을 통해 16/29 또는 22/29 (바이오-기반 에틸 아세테이트 포함) 이상.
반응식 2.
단계 1: Justus Liebigs Annalen der Chemie, Vol. 164, p. 162,176.
단계 2: Song, Bingrui et al. Advanced Synthesis and Catalysis, 2011, Vol. 353, No. 10 p. 1688 - 1694
단계 3: Arnold, Donald R. et al. Canadian Journal of Chemistry, 1987, Vol. 65, p. 2734 -2743.
단계 4: Synthetic Communications, Vol. 10, No. 1 1 p . 881-888.
단계 5: Yaksh 미국특허 5,994,372 A Peripherally active anti-hyperalgesic opiates.
단계 6: Chen et al. Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 2 1 p. 5275-5279.
또 다른 예에서, 약학적 유효량의 바이오-기반 또는 일부 바이오-기반 메펜터 민이 아래에 도시된 바와 같이 개시된다.
이 화합물은 완전히 바이오-기반이거나 페닐그룹만 바이오-기반일 수 있다; 또는 메펜터민 구조에 있는 탄소 원자의 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 또는 적어도 90%, 또는 30% 내지 90%, 또는 30%에서 80%, 또는 40%에서 90%, 또는 50%에서 100%는 바이오 기반이다. 이 화합물은 실질적으로 완전히 바이오-기반일 수 있다. 위 실시예에서 “메펜터민”을 대체하는 표 1의 각각의 화합물이 한 번에 하나씩 고려된다.
다른 바람직한 실시예에서, 활성 화합물은 이부프로펜이다:
이 화합물은 완전히 바이오-기반이거나 페닐기만 바이오-기반일 수 있다; 또는 이부프로펜 구조의 탄소 원자의 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 또는 적어도 90%, 또는 30% 내지 90% , 또는 30%에서 80%, 또는 40%에서 90%, 또는 50%에서 100%가 바이오-기반일 수 있다. 이 화합물은 실질적으로 완전히 바이오-기반일 수 있다.
또 다른 실시 양태에서, 약학적 유효 용량의 바이오 기반 또는 일부 바이오 기반 약학적 활성 화합물 또는 약학 조성물을 투여하거나 처방하는 것을 포함하는 환자 치료 방법이 개시된다. 일부 실시 양태에서, 환자는 화합물 또는 조성물이 바이오 기반임을 인지하거나 알고 있다. 일부의 경우에, 이 방법은 조성물이 바이오-기반 활성 성분을 포함하는 것을 환자에게 알리는 단계를 포함한다. 환자는 구두 또는 서면 (예로, 라벨을 통해), 또는 둘 다로 알림을 받을 수 있다.
또 다른 실시 양태에서, 약학적으로 유효한 바이오-기반 물질이 다른 약물 또는 약물들과 함께 두 물질을 모두 포함하여 공통 투여량으로 사용되는 치료, 바이오-기반 물질과 다른 물질(들)이 두 물질을 모두 포함하는 용법으로 투여를 하는 순차적인 치료에 사용되는 환자를 치료하는 방법이 개시된다.
개시된 조성물은 바이오-기반 약학적 활성 화합물에 더하여 통상적인 약학적 활성 화합물을 함유할 수 있다.
본 개시 내용은 약학적 활성 화합물이 제조되는 임의의 특정 방법 또는 방법들에 제한되지 않는다. 전형적으로, 본 발명의 구조는 촉매의 존재하에 바이오매스를 열분해하여 얻은 생성물을 사용하여 제조된다. 촉매 열분해 공정은 방향족, 특히 벤젠, 톨루엔 및 자일렌의 높은 수율을 생산하기 위해 수행될 수 있다. 약물 구조의 합성에서 이러한 바이오-기반 방향족의 후속 사용으로 방향족 고리 (부착된 메틸기 또는 메톡시기와 선택적으로 함께)가 바이오-기반인 약물 구조를 생성할 수 있다.
본원에 기술된 일부 또는 완전히 바이오-기반의 화합물 및 조성물은 석유-화학물질로부터 유래된 통상적인 약학 화합물 및 조성물을 대체한다. 대부분의 “천연물”은 단지 자연계에서의 존재 여부에 따라 발견될 뿐이고, 상업적 규모의 석유화학-기반의 합성 화학 공정을 통해 제조된다. 발효 과정을 통해 또는 천연 공급원으로부터 추출을 통해 제조되는 희귀한 상업적으로 이용 가능한 약학적 활성 화합물은 “바이오 공급원”(그리고 명백한 동위 원소 14C/12C 비율을 가짐)이며 이러한 상업적으로 이용 가능한 약학적 활성 화합물은 청구되는 소재(subject matter)에 포함되지 않는다; 더 높은 질량%의 바이오-기반 탄소를 갖는 일부 또는 완전히 바이오-기반인 화합물 및 조성물이 청구되는 소재에 포함된다.
일부 바람직한 실시 양태에서, 약물 구조는 세티리진 또는 방향족 고리 구조를 포함하는 다른 항히스타민이다. 일부 바람직한 실시 양태에서, 약물 구조는 적어도 부분적으로 바이오-기반인 벤젠, 톨루엔, 또는 자일렌, 또는 C9+ 방향족 또는 이들의 일부 혼합물을 사용하여 생성된다. 일부 실시 양태에서, 약학적으로 유효 용량은 약물 질량이 적어도 0.1 mg, 또는 적어도 0.5 mg, 또는 적어도 1 mg, 또는 적어도 5mg, 또는 적어도 10mg, 또는 0.01 내지 10mg, 또는 0.5 내지 5mg인 정제, 캡슐, 주사 가능하거나 기타 투여 형태의 형태이다.
실시예 - 환자 순응도
영국 (UK) 거주자 101 명, 독일 (DE) 거주자 106 명, 스웨덴 (SE) 거주자 63 명을 대상으로 설문 조사를 실시했으며 모두 세티리진을 사용한다. 이 설문 조사에 참여한 사람들은 세티리진에 대한 일련의 질문을 받았다. 도 1에서 볼 수 있듯이, 세티리진에 함유된 식물 물질의 비율이 높을수록 더 많은 사람들이 바이오-기반 의약품을 구매하게 된다. 설문 조사에 참여한 사람들은 또한“만약 약물이 환경 친화적인 재생 가능한 원료 식물 물질로 제조한 경우, 표준 물질/합성 화학 물질로 만든 동일한 약물일 경우보다 당신의 약물 치료 과정을 완료할 가능성이 더 높을 것이라 생각하는가? 1은 가능성이 훨씬 적고 5는 가능성이 훨씬 높은 1-5 점으로 평가하십시오”라는 질문을 받았다. 이 질문에서, 놀랍게도 바이오-기반 세티리진이 순응도 (순응도)를 증가시켜 사람들이 약물 복용에 순응할 가능성이 48% 내지 67% 더 높거나 훨씬 더 높음을 발견했다. 이러한 결과는 도 2에 나와 있다.
이부프로펜 약물에 대해서도 유사한 결과가 얻어졌다. 50% 식물 원료로 만든 이부프로펜 포장을 보여준 후 응답자들은“환자가 그의/그녀의 약을 평소에 복용하는 것보다 순응할 가능성이 더 높거나, 높거나, 또는 더 낮을 지”질문을 받았다. 도 3에서 볼 수 있듯이 405 명의 독일 거주자를 대상으로 한 설문 조사에서 응답자의 45%는 환자가 바이오-기반 약물 복용에 더 순응할 것이라고 생각했다.
따라서 데이터에 따르면 바이오-기반 의약품 (화석 연료에 비해 14C / 12C 비율이 높음)을 사용하면 환자 순응도가 놀랍도록 향상된다.
표 1은 저분자 약물 목록이다.
표 1 | 분자식 |
포스카르네트(foscarnet; Phosphonoformic acid; Phosphonoformate ...) | CH3O5P |
클로드로네이트(Clodronate; Clodronic Acid; Dichloromethanediphosphonic acid ...) | CH4Cl2O6P2 |
에티드로닉산(Etidronic acid; etidronate; HEDP ...) | C2H8O7P2 |
할로탄(halothane; Fluothane; Narcotan ...) | C2HBrClF3 |
파미드로네이트(pamidronate; PAMIDRONIC ACID; Amidronate ...) | C3H11NO7P2 |
엔플루란(enflurane; Ethrane; Methylflurether ...) | C3H2ClF5O |
이소플루란(isoflurane; Forane; Aerrane ...) | C3H2ClF5O |
수프란(Suprane; DESFLURANE; Desfluranum [INN-Latin] ...) | C3H2F6O |
페톡시플루란(methoxyflurane; Penthrane; Anecotan ...) | C3H4Cl2F2O |
니트로글리세린(nitroglycerin; Nitrostat; Glyceryl trinitrate ...) | C3H5N3O9 |
포스포마이신(FOSFOMYCIN; phosphomycin; Phosphonomycin ...) | C3H7O4P |
포스미도마이신(fosmidomycin; Fosmidomycina; Fosmidomycine ...) | C4H10NO5P |
메트포르민(metformin; Glucophage; Glumetza ...) | C4H11N5 |
트로메타민(TROMETHAMINE; Trometamol; Tris ...) | C4H11NO3 |
알렌드로네이트(alendronate; ALENDRONIC ACID; Fosamax ...) | C4H13NO7P2 |
세포플루란(sevoflurane; Ultane; Sevofluran ...) | C4H3F7O |
5-플루오로우라실(5-Fluorouracil; fluorouracil; 5-FU ...) | C4H3FN2O2 |
메티마졸(methimazole; thiamazole; Tapazole ...) | C4H6N2S |
아세타졸아미드(acetazolamide; Diamox; Diacarb ...) | C4H6N4O3S2 |
졸드론산(Zoledronic acid; Zoledronate; Reclast ...) | C5H10N2O7P2 |
메클로레타민(mechlorethamine; Chlormethine; Nitrogen mustard ...) | C5H11Cl2N |
D-페니실라민(D-Penicillamine; Cuprimine; Depen ...) | C5H11NO2S |
아캄프로세이트(Acamprosate; N-Acetylhomotaurine; Campral ...) | C5H11NO4S |
오로트산(Orotic acid; 6-Carboxyuracil; Orodin ...) | C5H4N2O4 |
알로푸리놀(allopurinol; Zyloprim; Lopurin ...) | C5H4N4O |
6-메르캡토퓨린(6-Mercaptopurine; mercaptopurine; Purinethol ...) | C5H4N4S |
피라진아미드(pyrazinamide; pyrazinecarboxamide; pyrazinoic acid amide ...) | C5H5N3O |
6-티오구아닌(6-Thioguanine; thioguanine; Tioguanine ...) | C5H5N5S |
메타졸아미드(methazolamide; Methenamide; Neptazaneat ...) | C5H8N4O3S2 |
카르무스틴(carmustine; BCNU; Carmustin ...) | C5H9Cl2N3O2 |
히스타민(histamine; 1H-Imidazole-4-ethanamine; 2-(4-Imidazolyl)ethylamine ...) | C5H9N3 |
베타졸(BETAZOLE; Ametazole; 1H-Pyrazole-3-ethanamine ...) | C5H9N3 |
L-프롤린(L-proline; proline; L-(-)-Proline ...) | C5H9NO2 |
N-아세틸-L-시스테인(N-Acetyl-L-cysteine; acetylcysteine; N-Acetylcysteine ...) | C5H9NO3S |
L-글루탐산(L-glutamic acid; L-glutamate; glutacid ...) | C5H9NO4 |
메글루톨(MEGLUTOL; 3-Hydroxy-3-methylglutaric acid; Dicrotalic acid ...) | C6H10O5 |
비가바트린(vigabatrin; Sabril; gamma-Vinyl GABA ...) | C6H11NO2 |
6-아미노카프로산(6-aminohexanoic acid; aminocaproic acid; 6-Aminocaproic acid ...) | C6H13NO2 |
이소파고민(Isofagomine; Afegostat; (3R,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-3,4-DIOL ...) | C6H13NO3 |
L-리신(L-lysine; lysine; lysine acid ...) | C6H14N2O2 |
L-아르기닌(L-arginine; arginine; L-(+)-Arginine ...) | C6H14N4O2 |
부설판(busulfan; Myleran; Busulphan ...) | C6H14O6S2 |
카르바콜린(Carbacholin; Carbacholine; Carbacolina ...) | C6H15N2O2+ |
디클로르펜아미드(dichlorphenamide; Diclofenamide; Dichlofenamide ...) | C6H6Cl2N2O4S2 |
린단(lindane; Kwell; beta-BHC ...) | C6H6Cl6 |
니코틴아미드(nicotinamide; niacinamide; 3-Pyridinecarboxamide ...) | C6H6N2O |
테모졸로미드(temozolomide; Methazolastone; Temodar ...) | C6H6N6O2 |
이소니아지드(isoniazid; Isonicotinic acid hydrazide; Isonicotinohydrazide ...) | C6H7N3O |
아밀로라이드(AMILORIDE; Amipramidin; Midamor ...) | C6H8ClN7O |
설파닐아미드(sulfanilamide; 4-Aminobenzenesulfonamide; Sulphanilamide ...) | C6H8N2O2S |
아스코르빅산(ascorbic acid; l-ascorbic acid; vitamin C ...) | C6H8O6 |
시트르산(citric acid; Citro; citrate ...) | C6H8O7 |
메트로니다졸(metronidazole; Flagyl; Metronidazol ...) | C6H9N3O3 |
트리메타디온(trimethadione; Troxidone; Tridione ...) | C6H9NO3 |
이소소르비드 모노니트레이트(ISOSORBIDE MONONITRATE; Monoket; Imdur ...) | C6H9NO6 |
카르비마졸(Carbimazole; Athyromazole; Carbimazol ...) | C7H10N2O2S |
프로필티오우라실(propylthiouracil; 6-Propyl-2-thiouracil; Procasil ...) | C7H10N2OS |
에토숙시마이드(ethosuximide; Zarontin; Etosuximida ...) | C7H11NO2 |
파라메타디온(PARAMETHADIONE; Paradione; Isoethadione ...) | C7H11NO3 |
리세드론산(Risedronate; Risedronic acid; 105462-24-6 ...) | C7H11NO7P2 |
시클로포스파미드(cyclophosphamide; Cyclophosphamid; Procytox ...) | C7H15Cl2N2O2P |
이포스파미드(ifosfamide; Isophosphamide; Iphosphamide ...) | C7H15Cl2N2O2P |
L-카르니틴(L-carnitine; Levocarnitine; Carnitor ...) | C7H15NO3 |
클로르족사존(chlorzoxazone; Paraflex; Biomioran ...) | C7H4ClNO2 |
클로로티아자이드(chlorothiazide; Diuril; Chlotride ..._ | C7H6ClN3O4S2 |
살리실산(salicylic acid; 2-Hydroxybenzoic acid; o-hydroxybenzoic acid ...) | C7H6O3 |
5-아미노살리실산(5-Aminosalicylic acid; mesalamine; Mesalazine ...) | C7H7NO3 |
하이드로클로로티아자이드(hydrochlorothiazide; Hypothiazide; Esidrix ...) | C7H8ClN3O4S2 |
에트클로르비놀(ethchlorvynol; Ethchlorovynol; Placidyl ...) | C7H9ClO |
엠트리시타바인(Emtricitabine; Coviracil; Emtriva ...) | C8H10FN3O3S |
설파아세트아미드(sulfacetamide; Sulphacetamide; Acetosulfamine ...) | C8H10N2O3S |
에티온아미드(ethionamide; Trecator; Ethioniamide ...) | C8H10N2S |
엔프로필린(ENPROFYLLINE; 3-Propylxanthine; 3-n-Propylxanthine ...) | C8H10N4O2 |
라미부딘(lamivudine; Epivir; Zeffix ...) | C8H11N3O3S |
아시클로버(acyclovir; Acycloguanosine; Aciclovir ...) | C8H11N5O3 |
도파민(dopamine; Hydroxytyramin; intropin ...) | C8H11NO2 |
피리독신(pyridoxine; Pyridoxol; Gravidox ...) | C8H11NO3 |
노르에피네프린(norepinephrine; noradrenaline; Arterenol ...) | C8H11NO3 |
베타히스타민(betahistine; 2-(2-METHYLAMINOETHYL)PYRIDINE; Vasomotal ...) | C8H12N2 |
페넬진(Phenelzine; Phenethylhydrazine; Nardil ...) | C8H12N2 |
바르비탈(barbital; Barbitone; Veronal ...) | C8H12N2O3 |
데시타빈(Decitabine; 5-Aza-2'-deoxycytidine; Dacogen ...) | C8H12N4O4 |
리바버린(ribavirin; Tribavirin; Virazole ...) | C8H12N4O5 |
5-아자시티딘(5-azacytidine; Azacitidine; Azacytidine ...) | C8H12N4O5 |
레비티라세탐(LEVITIRACETAM; Levetiracetam [INN]; Levetiracetamum [INN-Latin] ...) | C8H14N2O2 |
파모티딘(famotidine; PEPCID; Famodil ...) | C8H15N7O2S3 |
발프론산(VALPROIC ACID; 2-Propylpentanoic acid; Depakene ...) | C8H16O2 |
프레가발린(Pregabalin; Lyrica; 3-isobutyl GABA ...) | C8H17NO2 |
미그리톨(MIGLITOL; Glyset; 72432-03-2 ...) | C8H17NO5 |
릴루졸(riluzole; Rilutek; 1744-22-5 ...) | C8H5F3N2OS |
디아족사이드(diazoxide; Proglycem; Eudemine ...) | C8H7ClN2O2S |
푸라졸리돈(furazolidone; Furoxone; Furazolidine ...) | C8H7N3O5 |
이구아나벤즈(guanabenz; Wy 8678 base; Wytensin ...) | C8H8Cl2N4 |
트리클로르메티아자이드(trichlormethiazide; Trichloromethiazide; Naqua ...) | C8H8Cl3N3O4S2 |
하이드로플루메티아자이드(hydroflumethiazide; Diuredemina; Diurometon ...) | C8H8F3N3O4S2 |
조니스아미드(zonisamide; Zonegran; Exceglan ...) | C8H8N2O3S |
하이드랄라진(hydralazine; 1-Hydrazinophthalazine; Apresolin ...) | C8H8N4 |
아스트아미노펜(acetaminophen; Paracetamol; 4-Acetamidophenol ...) | C8H9NO2 |
클라벌란산(CLAVULANIC ACID; Clavulanate; Antibiotic MM 14151 ...) | C8H9NO5 |
비발리루딘(Bivalirudin; Angiomax; Hirulog ...) | C98H138N24O33 |
아프라클로니딘(apraclonidine; Iopidine; 4-Aminoclonidine ...) | C9H10Cl2N4 |
페나세미드(phenacemide; Phenuron; Phenurone ...) | C9H10N2O2 |
아미노히푸르산(aminohippuric acid; 4-Aminohippuric acid; P-AMINOHIPPURIC ACID ...) | C9H10N2O3 |
설파메티졸(sulfamethizole; Sulphamethizole; Sulfamethizol ...) | C9H10N4O2S2 |
메티클로티아자이드(methyclothiazide; Aquatensen; Enduron ...) | C9H11Cl2N3O4S2 |
젬시타빈(gemcitabine; dFdC; Gemcin ...) | C9H11F2N3O4 |
플록스우리딘(floxuridine; 2'-Deoxy-5-fluorouridine; FUDR ...) | C9H11FN2O5 |
이독스우리딘(idoxuridine; 5-Iodo-2'-deoxyuridine; Stoxil ...) | C9H11IN2O5 |
벤조카인(benzocaine; Ethyl 4-aminobenzoate; Americaine ...) | C9H11NO2 |
L-페닐알라닌(L-phenylalanine; phenylalanine; 3-Phenyl-L-alanine ...) | C9H11NO2 |
L-티로신(L-tyrosine; tyrosine; (S)-Tyrosine ...) | C9H11NO3 |
레보도파(levodopa; L-dopa; Dopar ...) | C9H11NO4 |
덱스트로암페타민(dextroamphetamine; Dexamphetamine; D-Amphetamine ...) | C9H13N |
이프로니아지드(iproniazid; Marsilid; Rivivol ...) | C9H13N3O |
잘시타빈(zalcitabine; Dideoxycytidine; 2',3'-DIDEOXYCYTIDINE ...) | C9H13N3O3 |
시타라빈(cytarabine; Ara-C; Cytosine arabinoside ...) | C9H13N3O5 |
간시클로버(ganciclovir; Cytovene; Gancyclovir ...) | C9H13N5O4 |
페닐프로파놀라민(phenylpropanolamine; Norephedrine; Rhindecon ...) | C9H13NO |
에티나메이트(ethinamate; Ethinamat; Valmid ...) | C9H13NO2 |
메타라미놀(metaraminol; L-Metaraminol; Hydroxynorephedrine ...) | C9H13NO2 |
페닐에프린(phenylephrine; Neosynephrine; Mezaton ...) | C9H13NO2 |
레보노르데프린(levonordefrin; Nordefrin; Neo-Cobefrin ...) | C9H13NO3 |
에피네프린(epinephrine; Adrenalin; l-Adrenaline ...) | C9H13NO3 |
메스아비탈(metharbital; Gemonil; Methylbarbital ...) | C9H14N2O3 |
미녹시딜(minoxidil; Loniten; Rogaine ...) | C9H15N5O |
쿠반(Kuvan; 5,6,7,8-tetrahydrobiopterin; tetrahydrobiopterin ...) | C9H15N5O3 |
캡토프릴(captopril; Capoten; Cesplon ...) | C9H15NO3S |
루머스틴(lomustine; Belustine; CeeNU ...) | C9H16ClN3O2 |
아젤라산(azelaic acid; NONANEDIOIC ACID; Finacea ...) | C9H16O4 |
가바펜틴(gabapentin; Neurontin; Gabapentine ...) | C9H17NO2 |
메프로바메이트(meprobamate; Amepromat; Equanil ...) | C9H18N2O4 |
알트라타민(altretamine; Hexalen; Hexastat ...) | C9H18N6 |
이반드론산(Ibandronic Acid; Ibandronate; Bondronat ...) | C9H23NO7P2 |
할로프로진(haloprogin; Halotex; Mycanden ...) | C9H4Cl3IO |
클로록신(chloroxine; 5,7-Dichloro-8-hydroxyquinoline; Capitrol ...) | C9H5Cl2NO |
클리오퀴놀(clioquinol; Iodochlorhydroxyquin; Vioform ...) | C9H5ClINO |
라모트리진(lamotrigine; Lamictal; Lamictal Cd ...) | C9H7Cl2N5 |
아자티오프린(azathioprine; Imuran; Azothioprine ...) | C9H7N7O2S |
티자니딘(tizanidine; Sirdalud; Ternelin ...) | C9H8ClN5S |
클로니딘(clonidine; Duraclon; Chlornidinum ...) | C9H9Cl2N3 |
구안파신(GUANFACINE; Estulic; Intuniv ...) | C9H9Cl2N3O |
설파디아진(sulfadiazine; Sulphadiazine; Sulfapyrimidine ...) | C10H10N4O2S |
클로파라빈(Clofarabine; Clolar; Evoltra ...) | C10H11ClFN5O3 |
트리플루리딘(Trifluridine; Viroptic; TRIFLUOROTHYMIDINE ...) | C10H11F3N2O5 |
설파메톡사졸(sulfamethoxazole; Sulfisomezole; Gantanol ...) | C10H11N3O3S |
퀴네타존(QUINETHAZONE; Chinethazonum; Quinethazon ...) | C10H12ClN3O3S |
클라드리빈(Cladribine; 2-Chloro-2'-deoxyadenosine; Leustatin ...) | C10H12ClN5O3 |
바클로펜(baclofen; Lioresal; Baclon ...) | C10H12ClNO2 |
톨라졸린(tolazoline; Priscoline; 2-Benzylimidazoline ...) | C10H12N2 |
스타부딘(stavudine; sanilvudine; Zerit ...) | C10H12N2O4 |
디다노신(didanosine; DIDEOXYINOSINE; Videx ...) | C10H12N4O3 |
타조박탐(Tazobactam; 89786-04-9; CHEMBL404 ...) | C10H12N4O5S |
클로르프로파미드(chlorpropamide; Chloropropamide; Diabinese ...) | C10H13ClN2O3S |
플루다라빈(fludarabine phosphate; fludara; FAMP ...) | C10H13FN5O7P |
데브리소퀸(Debrisoquine; Debrisoquin; Debrisochinum ...) | C10H13N3 |
비다라빈(Vidarabine; Ara-A; Vira-A ...) | C10H13N5O4 |
지도부딘(zidovudine; Azidothymidine; Retrovir ...) | C10H13N5O4 |
아데노신(adenosine; Adenocard; Adenoscan ...) | C10H13N5O4 |
텐암페타민(Tenamfetamine; 3,4-methylenedioxyamphetamine;) Methylenedioxyamphetamine ... | C10H13NO2 |
펜아세틴(phenacetin; Acetophenetidin; Acetophenetin ...) | C10H13NO2 |
메티로신(Metirosine; METYROSINE; Methyltyrosine ...) | C10H13NO3 |
메틸도파(methyldopa; Aldomet; Alphamethyldopa ...) | C10H13NO4 |
N-니코틴(Black leaf; L-Nicotine; Nicocide ...) | C10H14N2 |
알루레이트(APROBARBITAL; Alurate; Allypropymal ...) | C10H14N2O3 |
카르비도파(carbidopa; Lodosyn; N-Aminomethyldopa ...) | C10H14N2O4 |
텔비부딘(Telbivudine; Tyzeka; L-Thymidine ...) | C10H14N2O5 |
다이필린(dyphylline; Diprophylline; Glyphylline ...) | C10H14N4O4 |
아데닐산(5'-adenylic acid; adenylic acid; Adenosine monophosphate ...) | C10H14N5O7P |
메스암페타민(METHAMPHETAMINE; Metamfetamine; d-Deoxyephedrine ...) | C10H15N |
펜테르민(phentermine; Duromine; Ionamin ...) | C10H15N |
펜포민(PHENFORMIN; Phenformine; Fenformin ...) | C10H15N5 |
펜시클로버(penciclovir; Denavir; Vectavir ...) | C10H15N5O3 |
슈도에페드린(PSEUDOEPHEDRINE; Isoephedrine; d-Pseudoephedrine ...) | C10H15NO |
피포브로만(pipobroman; Vercyte; Amedel ...) | C10H16Br2N2O2 |
부타바르비탈(butabarbital; Secbutabarbital; Butisol ...) | C10H16N2O3 |
도르졸아미드(dorzolamide; 1cil; Trusopt (TN) ...) | C10H16N2O4S3 |
에데트산(EDTA; Edetic acid; Ethylenediaminetetraacetic acid ...) | C10H16N2O8 |
시메티딘(cimetidine; Tagamet; Cimetag ...) | C10H16N6S |
아만타딘(amantadine; 1-Adamantanamine; 1-Aminoadamantane ...) | C10H17N |
덱스프라미펙솔(Dexpramipexole; 104632-28-2; Pramipexol ...) | C10H17N3S |
메티프릴론(methyprylon; Noludar; Metiprilon ...) | C10H17NO2 |
구아나드렐(GUANADREL; Hylorel; Guanadrelum [INN-Latin] ...) | C10H19N3O2 |
디설피람(disulfiram; Tetraethylthiuram disulfide; Antabuse ...) | C10H20N2S4 |
I-멘톨(l-Menthol; (-)-menthol; Levomenthol ...) | C10H20O |
디에틸카르바마진(diethylcarbamazine; Carbamazine; Hetrazan ...) | C10H21N3O |
미글루스타트(Miglustat; Zavesca; N-Butylmoranoline ...) | C10H21NO4 |
보글리보스(voglibose; Basen; Glustat ...) | C10H21NO7 |
구아네티딘(GUANETHIDINE; Ismelin; Oktadin ...) | C10H22N4 |
아나그렐리드(anagrelide; Anagrelida; Anagrelidum ...) | C10H7Cl2N3O |
티아벤다졸(thiabendazole; Tiabendazole; Mintezol ...) | C10H7N3S |
페미로라스트(Pemirolast; Pemirolastum [INN-Latin]; Pemirolast [INN] ...) | C10H8N6O |
암리논(Amrinone; inamrinone; Inocor ...) | C10H9N3O |
브리모니딘(brimonidine; Bromoxidine; 59803-98-4 ...) | C11H10BrN5 |
메토프린(METOPRINE; Methodichlorophen; DDMP ...) | C11H10Cl2N4 |
플루트아미드(flutamide; Eulexin; Niftolide ...) | C11H11F3N2O3 |
설파피리딘(sulfapyridine; Sulphapyridine; 2-Sulfapyridine ...) | C11H11N3O2S |
로펙시딘(Lofexidine; Britlofex; Lofexidinum [INN-Latin] ...) | C11H12Cl2N2O |
클로르메자논(chlormezanone; Chlormethazanone; Trancopal ...) | C11H12ClNO3S |
안티피린(antipyrine; Phenazone; Anodynin ...) | C11H12N2O |
에토토인(ethotoin; Peganone; Ethotoine [INN-French] ...) | C11H12N2O2 |
L-트립토판(L-tryptophan; tryptophan; Tryptophane ...) | C11H12N2O2 |
질루톤(ZILEUTON; Zyflo; Leutrol ...) | C11H12N2O2S |
레바미솔(levamisole; L-Tetramisole; Lepuron ...) | C11H12N2S |
설파메라진(sulfamerazine; Sulphamerazine; Sulfamethyldiazine ...) | C11H12N4O2S |
설파렌(SULFALENE; Sulfamethopyrazine; Kelfizina ...) | C11H12N4O3S |
폴리티아지드(polythiazide; Renese; Drenusil ...) | C11H13ClF3N3O4S3 |
파르글린(pargyline; Eudatin; Paragyline ...) | C11H13N |
설프이속사졸(sulfisoxazole; Sulfafurazole; Sulphafurazole ...) | C11H13N3O3S |
펠바메이트(felbamate; Felbatol; Felbamyl ...) | C11H14N2O4 |
넬아라빈(Nelarabine; Nelzarabine; Arranon ...) | C11H15N5O5 |
펜메트라진(phenmetrazine; 3-Methyl-2-phenylmorpholine; Oxazimedrine ...) | C11H15NO |
프롤암페타민(Brolamfetamine; 4-Bromo-2,5-dimethoxyamphetamine; DOB-4 ...) | C11H16BrNO2 |
프로구아닐(proguanil; Chloroguanide; Chlorguanide ...) | C11H16ClN5 |
토카나이드(tocainide; Tonocard; Tocainidum [INN-Latin] ...) | C11H16N2O |
필로카르핀(pilocarpine; Isoptocarpine; Pilocarpin ...) | C11H16N2O2 |
불타비탈(butalbital; Allylbarbital; Itobarbital ...) | C11H16N2O3 |
덱스라족산(Dexrazoxane; Zinecard; Cardioxane ...) | C11H16N4O4 |
브레틸리움(Bretylium; Bretylium tolsylate; Bretylum ...) | C11H17BrN+ |
메펜테르민(MEPHENTERMINE; Mephenterdrine; Mefenterdrin ...) | C11H17N |
멕실레틴(Mexiletine; Mexiletene; Mexiletina ...) | C11H17NO |
이소프로테레놀(isoproterenol; Isoprenaline; Norisodrine ...) | C11H17NO3 |
메타프로테레놀(metaproterenol; ORCIPRENALINE; Alupent ...) | C11H17NO3 |
메톡사민(methoxamine; Methoxamedrine; Methoxamin ...) | C11H17NO3 |
아모바르비탈(amobarbital; Amylobarbitone; Amytal ...) | C11H18N2O3 |
펜토바르비탈(pentobarbital; Pentobarbitone; Nembutal ...) | C11H18N2O3 |
메카밀아민(mecamylamine; Versamine; Mecamine ...) | C11H21N |
메나디온(menadione; Vitamin K3; 2-Methyl-1,4-naphthoquinone ...) | C11H8O2 |
소르비닐(Sorbinil; Sorbinilo; Sorbinilum ...) | C11H9FN2O3 |
닐루타미드(nilutamide; Anandron; Nilandron ...) | C12H10F3N3O4 |
시녹사신(cinoxacin; Cinobac; Compound 64716 ...) | C12H10N2O5 |
푸로세미드(furosemide; Frusemide; Lasix ...) | C12H11ClN2O5S |
펠데신(PELDESINE; Peldesine [USAN]; BCX-34 ...) | C12H11N5O |
트리암테렌(triamterene; Dyrenium; Noridil ...) | C12H11N7 |
댑손(dapsone; Diaphenylsulfone; Sulfona ...) | C12H12N2O2S |
에녹시몬(ENOXIMONE; Perfan; Fenoximone ...) | C12H12N2O2S |
날리딕스산nalidixic acid; Nalidixin; Nevigramon ... | C12H12N2O3 |
페노바르비탈(phenobarbital; Luminal; Phenobarbitol ...) | C12H12N2O3 |
다족시벤(DAZOXIBEN; Dazoxiben [INN-Spanish]; Dazoxibene [INN-French] ...) | C12H12N2O3 |
피리메타민(pyrimethamine; Daraprim; Ethylpyrimidine ...) | C12H13ClN4 |
라사질린(rasagiline; 136236-51-6; (R)-N-(2-Propynyl)-2,3-dihydroinden-1-amine ...) | C12H13N |
이소카르복사지드(isocarboxazid; Isocarbonazid; Isocarboxazide ...) | C12H13N3O2 |
메스석시미드(METHSUXIMIDE; Mesuximide; Celontin ...) | C12H13NO2 |
메페니토인(MEPHENYTOIN; Methoin; Phenantoin ...) | C12H14N2O2 |
프리미돈(primidone; Primaclone; Mysoline ...) | C12H14N2O2 |
설파메타진(sulfamethazine; Sulfadimidine; Sulfadimezine ...) | C12H14N4O2S |
설파시틴(sulfacytine; Renoquid; 1-Ethyl-N-sulfanilylcytosine ...) | C12H14N4O3S |
설파독신(SULFADOXINE; Sulphadoxine; Sulforthomidine ...) | C12H14N4O4S |
클로피브레이트(clofibrate; Atromid; Atromid-S ...) | C12H15ClO3 |
알벤다졸(albendazole; Valbazen; Albenza ...) | C12H15N3O2S |
엔테카비르(Entecavir; Baraclude; 142217-69-4 ...) | C12H15N5O3 |
펜플루라민(fenfluramine; Adifax; d-Fenfluramine ...) | C12H16F3N |
헥소바르비탈(Hexobarbital; Hexobarbitone; Evipal ...) | C12H16N2O3 |
이미페넴(imipenem; Imipemide; Tienamycin ...) | C12H17N3O4S |
티아민(thiamine; thiamin; Aneurin ...) | C12H17N4OS+ |
시클로피록스(CICLOPIROX; Loprox; Penlac ...) | C12H17NO2 |
클렌부테롤(clenbuterol; Planipart; Clenbuterolum ...) | C12H18Cl2N2O |
티아밀랄(thiamylal; Thioseconal; Surital ...) | C12H18N2O2S |
톨부타미드(tolbutamide; Orinase; Diabetol ...) | C12H18N2O3S |
미도드린(midodrine; Midodrin; Midodrinum [INN-Latin] ...) | C12H18N2O4 |
프로포폴(propofol; 2,6-DIISOPROPYLPHENOL; Diprivan ...) | C12H18O |
프로카르바진(procarbazine; Natulan; Ibenzmethyzin ...) | C12H19N3O |
테르부탈린(terbutaline; Bricanyl; Brican ...) | C12H19NO3 |
피르부테롤(PIRBUTEROL; pyrbuterol; Maxair ...) | C12H20N2O3 |
소타롤(sotalol; beta-Cardone; Sotalolum ...) | C12H20N2O3S |
자나미비르(zanamivir; Relenza; Zanamavir ...) | C12H20N4O7 |
메만틴(memantine; Memantinum [INN-Latin]; Memantina [INN-Spanish] ...) | C12H21N |
리마타딘(rimantadine; Remantadine; Riamantadine ...) | C12H21N |
브린졸아민(Brinzolamide; Azopt; Birnzolamide ...) | C12H21N3O5S3 |
니자티딘(nizatidine; Axid; Acinon ...) | C12H21N5O2S2 |
토피라메이트(topiramate; Topamax; Epitomax ...) | C12H21NO8S |
비티오놀(bithionol; Lorothidol; Bithin ...) | C12H6Cl4O2S |
트리클로산(triclosan; 5-CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL; 3380-34-5 ...) | C12H7Cl3O2 |
레플루미드(leflunomide; Arava; 75706-12-6 ...) | C12H9F3N2O2 |
밀리논(milrinone; Primacor; 78415-72-2 ...) | C12H9N3O |
니타족사니드(NITAZOXANIDE; Alinia; 55981-09-4 ...) | C12H9N3O5S |
탈리도미드(thalidomide; Thalomid; Distaval ...) | C13H10N2O4 |
프로플라빈(Proflavin; Proflavine; 3,6-ACRIDINEDIAMINE ...) | C13H11N3 |
테녹시캄(tenoxicam; Mobiflex; Tilcotil ...) | C13H11N3O4S2 |
에타크리린산(ETHACRYNIC ACID; Edecrin; Hydromedin ...) | C13H12Cl2O4 |
플루코나졸(fluconazole; Diflucan; Triflucan ...) | C13H12F2N6O |
니메설파이드(nimesulide; Mesulid; Nimed ..._ | C13H12N2O5S |
모노벤존(Monobenzone; 4-Benzyloxyphenol; 4-(Benzyloxy)phenol ...) | C13H12O2 |
레날리도미드(Lenalidomide; Revlimid; Revimid ...) | C13H13N3O3 |
세파세트릴(Cephacetrile; Cefacetrile; Cefacetril ...) | C13H13N3O6S |
세피티족심(ceftizoxime; Ceftizoximum; Ceftizoxima ...) | C13H13N5O5S2 |
타크린(Tacrine; Tetrahydroaminoacridine; Romotal ...) | C13H14N2 |
메포바르비탈(Mephobarbital; Mebaral; Mephobarbitone ...) | C13H14N2O3 |
클로길린(Clorgiline; CLORGYLINE; Chlorgyline ...) | C13H15Cl2NO |
글루테티미드(glutethimide; Doriden; Noxiron ...) | C13H15NO2 |
케타민(ketamine; Ketaject; Ketanest ...) | C13H16ClNO |
메데토미딘(Medetomidine; Medetomidinum [Latin]; Medetomidina [Spanish] ...) | C13H16N2 |
아미노글루테티미드(aminoglutethimide; Cytadren; Orimeten ...) | C13H16N2O2 |
벨리파리브(Veliparib; ABT-888; 912444-00-9 ...) | C13H16N4O |
메클로베미드(moclobemide; Aurorix; Manerix ...) | C13H17ClN2O2 |
셀레길린(selegiline; Emsam; Jumex ...) | C13H17N |
암페부타몬(Amfebutamone; bupropion; Amfebutamon ...) | C13H18ClNO |
헵타바르비탈(Heptabarbital; Heptabarb; Heptabarbitone ...) | C13H18N2O3 |
페톡시필린(pentoxifylline; Trental; Oxpentifylline ...) | C13H18N4O3 |
이부프로펜(ibuprofen; Motrin; Brufen ...) | C13H18O2 |
클로로프로카인(CHLOROPROCAINE; Chloroprocain; Halestyn ...) | C13H19ClN2O2 |
디에틸프로피온(DIETHYLPROPION; Amfepramone; Diethylpropione ...) | C13H19NO |
프로베네시드(probenecid; Benemid; Probecid ...) | C13H19NO4S |
프릴로카인(prilocaine; Propitocaine; Citanest ...) | C13H20N2O |
브로카인(procaine; Novocaine; Duracaine ...) | C13H20N2O2 |
발라시클로버(valacyclovir; Valaciclovir; Valtrex ...) | C13H20N6O4 |
브로카인아미드(PROCAINAMIDE; Novocainamide; Biocoryl ...) | C13H21N3O |
살부타몰(Salbutamol; albuterol; Proventil ...) | C13H21NO3 |
이소에타린(isoetharine; Isoetarin; Isoetarine ...) | C13H21NO3 |
티모롤(timolol; Betimol; Istalol ...) | C13H24N4O3S |
헥사클로로펜(hexachlorophene; Hexachlorofen; Hexachlorophen ...) | C13H6Cl6O2 |
디플루니살(diflunisal; Dolobid; Dolobis ...) | C13H8F2O3 |
니플룸산(niflumic acid; Nifluril; Landruma ...) | C13H9F3N2O2 |
브로마제팜(bromazepam; Compedium; Lectopam ...) | C14H10BrN3O |
미토탄(mitotane; Lysodren; Chlodithane ...) | C14H10Cl4 |
니티시논(Nitisinone; Orfadin; 104206-65-7 ...) | C14H10F3NO5 |
단트롤렌(dantrolene; Dantroleno; Dantrolenum [INN-Latin] ...) | C14H10N4O5 |
살살레이트(Salsalate; sasapyrine; Disalcid ...) | C14H10O5 |
디클로페낙(diclofenac; Diclofenac acid; dichlofenac ...) | C14H11Cl2NO2 |
메클로페나메이트(meclofenamate; meclofenamic acid; Arquel ...) | C14H11Cl2NO2 |
클로르탈리돈(chlorthalidone; Chlortalidone; Phthalamudine ...) | C14H11ClN2O4S |
톨카폰(Tolcapone; Tasmar; 134308-13-7 ...) | C14H11NO5 |
레보시멘단(LEVOSIMENDAN; Simdax; Levosimedan ...) | C14H12N6O |
벤질벤조에이트(BENZYL BENZOATE; Ascabiol; Novoscabin ...) | C14H12O2 |
옥시벤존(oxybenzone; 2-HYDROXY-4-METHOXYBENZOPHENONE; 131-57-7 ...) | C14H12O3 |
서프로펜(suprofen; Profenal; Maldocil ...) | C14H12O3S |
티아프로펜산(tiaprofenic acid; Tiaprofensaeure; Surgam ...) | C14H12O3S |
멜록시캄(meloxicam; Mobic; Movalis ...) | C14H13N3O4S2 |
세프디니르(cefdinir; Omnicef; CFDN ...) | C14H13N5O5S2 |
티클로피딘(ticlopidine; Ticlid; Ticlopidina ...) | C14H14ClNS |
나파졸린(naphazoline; Naphthizine; Clearine ...) | C14H14N2 |
메티라폰(metyrapone; Metopirone; Metopiron ...) | C14H14N2O |
DL-나프록센(DL-Naproxen; Floginax; Naprius ...) | C14H14O3 |
나프록센(NAPROXEN; 22204-53-1; Naproxene ...) | C14H14O3 |
엔타카폰(ENTACAPONE; Comtan; Comtess ...) | C14H15N3O5 |
이로서스타트(Irosustat; 667-Coumate; 667 coumate ...) | C14H15NO5S |
시클로티아지드(cyclothiazide; Anhydron; Aquirel ...) | C14H16ClN3O4S2 |
이미퀴모드(IMIQUIMOD; Aldara; 99011-02-6 ...) | C14H16N4 |
오파비랄린(Opaviraline; GW420867X; Isopropyl (2s)-2-Ethyl-7-Fluoro-3-Oxo-3,4-Dihydroquinoxaline-1(2h)-Carboxylate ...) | C14H17FN2O3 |
플로바트립탄(Frovatriptan; Frova; Miguard ...) | C14H17N3O |
파수딜(Fasudil; AT 877; Fasudil [INN] ...) | C14H17N3O2S |
이부딜라스트(ibudilast; Ketas; Ke Tas ...) | C14H18N2O |
메토헥시탈(METHOHEXITAL; Methohexitone; Brevital ...) | C14H18N2O3 |
트리메토프림()trimethoprim; Proloprim; Trimpex ... | C14H18N4O3 |
클로람부실(chlorambucil; Leukeran; Ambochlorin ...) | C14H19Cl2NO2 |
팜시클로버(famciclovir; Famvir; 104227-87-4 ...) | C14H19N5O4 |
메틸페니데이트(methylphenidate; Daytrana; Methylphenidan ...) | C14H19NO2 |
핀돌롤(pindolol; Visken; Prinodolol ...) | C14H20N2O2 |
보리노스타트(Vorinostat; SAHA; Zolinza ...) | C14H20N2O3 |
수마트립탄(sumatriptan; Imitrex; Sumatran ...) | C14H21N3O2S |
옥삼니퀸(oxamniquine; Vansil; Mansil ...) | C14H21N3O3 |
톨라자미드(tolazamide; Tolinase; Norglycin ...) | C14H21N3O3S |
메토클로프라미드(metoclopramide; Primperan; Reliveran ...) | C14H22ClN3O2 |
리도카인(lidocaine; Xylocaine; Lignocaine ...) | C14H22N2O |
리바스티그민(rivastigmine; ENA 713 free base; 123441-03-2 ...) | C14H22N2O2 |
아테놀롤(atenolol; Tenormin; Prenormine ...) | C14H22N2O3 |
발간시클로버(Valganciclovir; Cymeval; L-Valine, ester with ganciclovir ...) | C14H22N6O5 |
스펙티노마이신(Spectinomycin; actinospectacin; Trobicin ...) | C14H24N2O7 |
엘라그산(ellagic acid; Benzoaric acid; Lagistase ...) | C14H6O8 |
에파비렌즈(efavirenz; Sustiva; Stocrin ...) | C14H9ClF3NO2 |
로라제팜(lorazepam; Ativan; Temesta ...) | C15H10Cl2N2O2 |
클로나제팜(clonazepam; Rivotril; Antelepsin ...) | C15H10ClN3O3 |
페닌디온(phenindione; 2-Phenyl-1,3-indandione; Phenylindanedione ...) | C15H10O2 |
옥사제팜(oxazepam; Adumbran; Serax ...) | C15H11ClN2O2 |
L-티록신(L-thyroxine; levothyroxine; synthroid ...) | C15H11I4NO4 |
니트라제팜(nitrazepam; Benzalin; Mogadon ..). | C15H11N3O3 |
브로페낙(Bromfenac; Duract; Xibrom ...) | C15H12BrNO3 |
카르프로펜(carprofen; Rimadyl; Imadyl ...) | C15H12ClNO2 |
리오티로닌(liothyronine; triiodothyronine; Tresitope ...) | C15H12I3NO4 |
카르바마제핀(carbamazepine; Tegretol; Carbamazepen ...) | C15H12N2O |
페니토인(phenytoin; 5,5-DIPHENYLHYDANTOIN; Diphenylhydantoin ...) | C15H12N2O2 |
옥스카르바제핀(OXCARBAZEPINE; Trileptal; Oxcarbamazepine ...) | C15H12N2O2 |
루미라콕시브(Lumiracoxib; Prexige; COX 189 ...) | C15H13ClFNO2 |
플루비프로펜(flurbiprofen; Ansaid; Froben ...) | C15H13FO2 |
피록시캄(piroxicam; Feldene; 36322-90-4 ...) | C15H13N3O4S |
케토롤락(ketorolac; Ketoralac; Ketorolacum [Latin] ...) | C15H13NO3 |
벤즈티아지드(benzthiazide; Benzothiazide; Aquatag ...) | C15H14ClN3O4S3 |
벤드로플루메티아지드(BENDROFLUMETHIAZIDE; Bendrofluazide; Naturetin ...) | C15H14F3N3O4S2 |
플루마제닐(flumazenil; Flumazepil; Romazicon ...) | C15H14FN3O3 |
네비라핀(nevirapine; Viramune; 129618-40-2 ...) | C15H14N4O |
세프티부텐(ceftibuten; Cedax; Ceftibuteno ...) | C15H14N4O6S2 |
페노프로펜(fenoprofen; 2-(3-Phenoxyphenyl)propanoic acid; Nalfon ...) | C15H14O3 |
메페남산(mefenamic acid; Ponstel; Parkemed ...) | C15H15NO2 |
톨메틴(tolmetin; Tolectin; Tolmetine ...) | C15H15NO3 |
나부메톤(nabumetone; Relafen; Listran ...) | C15H16O2 |
에녹사신(enoxacin; Penetrex; Comprecin ...) | C15H17FN4O3 |
세프포독심(CEFPODOXIME; Cefpodoxima; Cefpodoximum ...) | C15H17N5O6S2 |
세프메타졸(cefmetazole; Cefmetazolum; Cefmetazolo ...) | C15H17N7O5S3 |
미토마이신(mitomycin C; Mutamycin; Ametycine ...) | C15H18N4O5 |
리자트립탄(rizatriptan; Risatriptan; MK 462 free base ...) | C15H19N5 |
아세토헥사미드(acetohexamide; Dymelor; Gamadiabet ...) | C15H20N2O4S |
플루복사민(fluvoxamine; Floxyfral; Dumirox ...) | C15H21F3N2O2 |
펜캄파민(Fencamfamin; Euvitol; Reactivan ...) | C15H21N |
프리마퀸(PRIMAQUINE; Neo-Quipenyl; Primachin ...) | C15H21N3O |
피조스티그민(physostigmine; Eserine; Antilirium ... | C15H21N3O2 |
글릭라지드(gliclazide; Diamicron; Glimicron ...) | C15H21N3O3S |
메페리딘(meperidine; Pethidine; Demerol ...) | C15H21NO2 |
카페시타빈(CAPECITABINE; Xeloda; 154361-50-9 ...) | C15H22FN3O6 |
메피바카인(mepivacaine; Carbocaine; Scandicain ...) | C15H22N2O |
밀나시프란(Milnacipran; Midalcipran; Toledomin ...) | C15H22N2O |
젬피브로질(gemfibrozil; Lopid; Decrelip ...) | C15H22O3 |
메실리남(Mecillinam; Coactin; AMDINOCILLIN ...) | C15H23N3O3S |
시클라실린(ciclacillin; CYCLACILLIN; Bastcillin ...) | C15H23N3O4S |
설피리드(sulpiride; Aiglonyl; Sulpirid ...) | C15H23N3O4S |
알프레놀롤(alprenolol; Alfeprol; Yobir ...) | C15H23NO2 |
옥스프레놀롤(oxprenolol; Coretal; dl-Oxprenolol ...) | C15H23NO3 |
리스덱삼페타민(Lisdexamfetamine; NRP104; 608137-32-2 ...) | C15H25N3O |
메토프롤롤(metoprolol; Lopressor; Seloken ...) | C15H25NO3 |
마리마스타트(Marimastat; Marimastat [USAN]; BB-2516 ...) | C15H29N3O5 |
플루디아제팜(fludiazepam; Erispan; Fludiazepamum [INN-Latin] ...) | C16H12ClFN2O |
베녹사프로펜(Benoxaprofen; Oraflex; Inflamid ...) | C16H12ClNO3 |
플루니트라제팜(flunitrazepam; Rohypnol; Narcozep ...) | C16H12FN3O3 |
아니신디온(anisindione; Miradon; Anisin indandione ...) | C16H12O3 |
티오코나졸(tioconazole; Vagistat-1; Trosyl ...) | C16H13Cl3N2OS |
디아제팜(diazepam; Valium; Ansiolisina ...) | C16H13ClN2O |
마진돌(mazindol; Mazanor; Sanorex ...) | C16H13ClN2O |
클로바잠(Clobazam; Chlorepin; Urbanyl ...) | C16H13ClN2O2 |
테마제팜(temazepam; Crisonar; Restoril ...) | C16H13ClN2O2 |
메벤다졸(mebendazole; Vermox; Telmin ...) | C16H13N3O3 |
클로르디아제폭시드(chlordiazepoxide; Chlozepid; Elenium ...) | C16H14ClN3O |
란소프라졸(lansoprazole; Bamalite; Monolitum ...) | C16H14F3N3O2S |
보리코나졸(Voriconazole; Vfend; 137234-62-9 ...) | C16H14F3N5O |
톨레스타트(TOLRESTAT; Alredase; Tolrestatum ...) | C16H14F3NO3S |
암렉사녹스(amlexanox; Aphthasol; Amoxanox ...) | C16H14N2O4 |
케토프로펜(ketoprofen; Orudis; Profenid ...) | C16H14O3 |
클로티아제팜(clotiazepam; Trecalmo; Rizen ...) | C16H15ClN2OS |
판토프라졸(pantoprazole; Protonix; Pantozol ...) | C16H15F2N3O4S |
시타글립틴(Sitagliptin; Xelevia; Januvia ...) | C16H15F6N5O |
포스페니토인(Fosphenytoin; Prodilantin; Fosfenitoina [INN-Spanish] ...) | C16H15N2O6P |
에피나스틴(epinastine; Epinastinum [Latin]; Epinastina [Spanish] ...) | C16H15N3 |
타나프로게트(Tanaproget; 1zuc; NSP-989 ...) | C16H15N3OS |
인다파미드(indapamide; Tertensif; Arifon ...) | C16H16ClN3O3S |
메톨라존(metolazone; Zaroxolyn; Mykrox ...) | C16H16ClN3O3S |
클로피도그렐(clopidogrel; Plavix; (S)-Clopidogrel ...) | C16H16ClNO2S |
페놀도팜(fenoldopam; Corlopam; Fenoldopamum [Latin] ...) | C16H16ClNO3 |
페북소스타트(Febuxostat; 144060-53-7; Uloric ...) | C16H16N2O3S |
세팔로틴(cephalothin; Cefalotin; Cephalothinum ...) | C16H16N2O6S2 |
지멜딘(Zimeldine; Zimelidine; cis-Zimelidine ...) | C16H17BrN2 |
세팔렉신(cephalexin; Cefalexin; Cephacillin ...) | C16H17N3O4S |
세폭시틴(cefoxitin; Mefoxitin; Mefoxin ...) | C16H17N3O7S2 |
노르플록사신(norfloxacin; Noroxin; Chibroxin ...) | C16H18FN3O3 |
노미펜신(Nomifensine; nomifensin; Linamiphen ...) | C16H18N2 |
페니실린 g(penicillin g; Benzylpenicillin; Pencillin G ...) | C16H18N2O4S |
페니실린 v(penicillin v; Phenomycilline; Beromycin ...) | C16H18N2O5S |
프로페니라민(BROMPHENIRAMINE; Dimetane; Bromfeniramina ...) | C16H19BrN2 |
클로르페니라민(chlorpheniramine; Chlorphenamine; Chlor-trimeton ...) | C16H19ClN2 |
카르비녹사민(carbinoxamine; Paracarbinoxamine; Allergefon ...) | C16H19ClN2O |
세프라딘(cephradine; Cefradine; Anspor ...) | C16H19N3O4S |
암피실린(ampicillin; Omnipen; Ampicillin acid ...) | C16H19N3O4S |
아목시실린(amoxicillin; Amoxycillin; Amoxicilline ...) | C16H19N3O5S |
티비라핀(Tivirapine; CHEMBL58711; NSC636661 ...) | C16H20ClN3S |
리네졸리드(linezolid; Zyvox; Zyvoxid ...) | C16H20FN3O4 |
페니라민(pheniramine; Prophenpyridamine; Tripoton ...) | C16H20N2 |
토르세미드(TORSEMIDE; Torasemide; Demadex ...) | C16H20N4O3S |
타소시티니브(Tasocitinib; Tofacitinib; 477600-75-2 ...) | C16H20N6O |
트리펠레나민(tripelennamine; Pyribenzamine; Tripelennamin ...) | C16H21N3 |
라멜테온(Ramelteon; Rozerem; TAK-375 ...) | C16H21NO2 |
프로프라놀롤(propranolol; Propanolol; beta-Propranolol ...) | C16H21NO2 |
레목시프리드(Remoxipride; Romoxipride; Remoxipridum [INN-Latin] ...) | C16H23BrN2O3 |
펙실카인(HEXYLCAINE; Hexylcainum [INN-Latin]; Hexilcaina [INN-Spanish] ...) | C16H23NO2 |
옥시메타졸린(oxymetazoline; Oxymethazoline; Oxylazine ...) | C16H24N2O |
로피니롤(ropinirole; ReQuip; ropinirol ...) | C16H24N2O |
몰린돈(MOLINDONE; Moban; (+-)-Molindone ...) | C16H24N2O2 |
카르테오롤(CARTEOLOL; Carteololum; Carteololum [INN-Latin] ...) | C16H24N2O3 |
데스벤라팍신(Desvenlafaxine; O-Desmethylvenlafaxine; 93413-62-8 ...) | C16H25NO2 |
트라마돌(Tramadol; Ultram; Ralivia flashtab ...) | C16H25NO2 |
데스몰롤(ESMOLOL; (+-)-Esmolol; Esmolol [INN:BAN] ...) | C16H25NO4 |
프로파라카인(proparacaine; Ophthaine; Proxymetacaine ...) | C16H26N2O3 |
실라스타틴(Cilastatin; Cilastatina; Cilastatine ...) | C16H26N2O5S |
오셀타미비르(oseltamivir; Tamiflu; Tamvir ...) | C16H28N2O4 |
팔미트산(palmitic acid; Hexadecanoic acid; Cetylic acid ...) | C16H32O2 |
제나레스타트(Zenarestat; Zenarestatum; Zenarestatum [INN-Latin] ...) | C17H11BrClFN2O4 |
쿠아제팜(quazepam; Doral; Dormalin ...) | C17H11ClF4N2S |
레트로졸(letrozole; Femara; Letrozol ...) | C17H11N5 |
트리아졸람(triazolam; Halcion; Clorazolam ...) | C17H12Cl2N4 |
할라제팜(Halazepam; Paxipam; Pacinone ...) | C17H12ClF3N2O |
알프라졸람(alprazolam; Xanax; Cassadan ...) | C17H13ClN4 |
셀레콕시브(celecoxib; Celebrex; Celebra ...) | C17H14F3N3O2S |
로속사신(ROSOXACIN; Acrosoxacin; Eradacil ...) | C17H14N2O3 |
로페콕시브(rofecoxib; Vioxx; Ceoxx ...) | C17H14O4S |
잘레플론(zaleplon; Sonata; 151319-34-5 ...) | C17H15N5O |
아목사핀(amoxapine; Asendin; Demolox ...) | C17H16ClN3O |
라리암(Lariam; mefloquine; Mefloquinone ...) | C17H16F6N2O |
세르트라린(sertraline; Lustral; Zoloft ...) | C17H17Cl2N |
조피클론(zopiclone; Imovane; Amoban ...) | C17H17ClN6O3 |
세파피린(cephapirin; Cefapirin; Cephapirine ...) | C17H17N3O6S2 |
플루옥세틴(fluoxetine; Pulvules; Portal ...) | C17H18F3NO |
시프로플록사신(ciprofloxacin; Ciprobay; Cipro ...) | C17H18FN3O3 |
피레타니드(piretanide; Tauliz; Arelix (TN) ...) | C17H18N2O5S |
니페디파인(nifedipine; Procardia; Adalat ...) | C17H18N2O6 |
카르베니실린(carbenicillin; Pyopen; Carboxybenzylpenicillin ..._ | C17H18N2O6S |
알로세트론(alosetron; Lotronex; Alosetron HCl ...) | C17H18N4O |
클로르프로마진(chlorpromazine; Largactil; Thorazine ...) | C17H19ClN2S |
로메플록사신(lomefloxacin; Lomefloxacine; Lomefloxacino ...) | C17H19F2N3O3 |
안타졸린(antazoline; Antasten; Phenazoline ...) | C17H19N3 |
미르타자핀(mirtazapine; Remeron; Remergil ...) | C17H19N3 |
펜톨라민(phentolamine; Regitine; Rogitine ...) | C17H19N3O |
오메프라졸(omeprazole; Prilosec; Antra ...) | C17H19N3O3S |
아나스트로졸(anastrozole; Arimidex; anastrazole ...) | C17H19N5 |
피리트렉심(Piritrexim; Piritrexime [French]; Piritreximum [Latin] ...) | C17H19N5O2 |
하이드로모르폰(hydromorphone; Dihydromorphinone; Dimorphone ..._ | C17H19NO3 |
옥시모르폰(oxymorphone; Numorphan; Oximorphonum ...) | C17H19NO4 |
프로미디펜히드라민(Bromdiphenhydramine; bromodiphenhydramine; Bromazine ...) | C17H20BrNO |
클로페디아놀(CHLOPHEDIANOL; Chlofedanol; Dencyl ...) | C17H20ClNO |
플렉카이니드(flecainide; Flecaine; Tambocor ...) | C17H20F6N2O3 |
페플록사신(Pefloxacin; Pefloxacine; Pefloxacinum ...) | C17H20FN3O3 |
트로피카미드(tropicamide; Tropicacyl; Mydriacyl ...) | C17H20N2O2 |
부메타니드(bumetanide; Bumex; Fordiuran ...) | C17H20N2O5S |
메티실린(methicillin; Meticillin; Methicillinum ...) | C17H20N2O6S |
프로마진(promazine; Protactyl; Sinophenin ...) | C17H20N2S |
프로메타진(promethazine; Proazamine; Diphergan ...) | C17H20N2S |
올란자핀(olanzapine; Zyprexa; Zyprexa Zydis ...) | C17H20N4S |
마이코페놀산(mycophenolic acid; Melbex; Mycophenolate ...) | C17H20O6 |
디펜하이드라민(diphenhydramine; Benadryl; Alledryl ...) | C17H21NO |
아토목세틴(Atomoxetine; Tomoxetine; Tomoxetinum ...) | C17H21NO |
에토돌락(etodolac; Etodolic acid; Lodine ...) | C17H21NO3 |
리토드린(ritodrine; Yutopar; Ritodrina [INN-Spanish] ...) | C17H21NO3 |
페노테롤(fenoterol; Phenoterol; Berotec ...) | C17H21NO4 |
독실아민(doxylamine; Dossilamina [DCIT]; Doxylaminum [INN-Latin] ...) | C17H22N2O |
에미비린(Emivirine; Coactinon; MKC-442 ...) | C17H22N2O3 |
미나프린(minaprine; Cantor; Brantur ...) | C17H22N4O |
PF-734200; PF-00734200; 869490-23-3 ... | C17H24F2N6O |
펜시클리딘(PHENCYCLIDINE; Angel dust; 1-(1-Phenylcyclohexyl)piperidine ...) | C17H25N |
알모트립탄(Almotriptan; Axert; Almogran ...) | C17H25N3O2S |
나라트립탄(naratriptan; Naramig; Amerge ...) | C17H25N3O2S |
시클로펜톨레이트(cyclopentolate; Cyclogyl; Ciclopentolato ...) | C17H25NO3 |
레보부놀롤(LEVOBUNOLOL; Betagan; Akbeta ...) | C17H25NO3 |
시부트라민(sibutramine; Reductil; Medaria ...) | C17H26ClN |
에메다스틴(emedastine; Emadine; Emedastinum [INN-Latin] ...) | C17H26N4O |
아미설프라이드(amisulpride; Solian; Aminosultopride ...) | C17H27N3O4S |
벤라팍신(venlafaxine; Elafax; Venlafaxina ...) | C17H27NO2 |
메티프라놀롤(Metipranolol; Trimepranol; Disorat ...) | C17H27NO4 |
나도롤(nadolol; Corgard; Solgol ...) | C17H27NO4 |
옥시부프로카인(Oxybuprocaine; Benoxinate; Oxybucaine ...) | C17H28N2O3 |
리도레스타트(Lidorestat; IDD-676; IDD-000676-01 ...) | C18H11F3N2O2S |
미다졸람(midazolam; Dormicum; Versed ...) | C18H13ClFN3 |
시놀라제팜(Cinolazepam; Gerodorm; Cinolazepamum ...) | C18H13ClFN3O2 |
미코나졸(miconazole; Monistat; Daktarin IV ...) | C18H14Cl4N2O |
(R)-비칼루타미드((R)-Bicalutamide; R-BICALUTAMIDE; CHEBI:3090 ...) | C18H14F4N2O4S |
에코나졸(econazole; Ecostatin; Pevaryl ...) | C18H15Cl3N2O |
에토리콕시브(Etoricoxib; Arcoxia; Tauxib ...) | C18H15ClN2O2S |
시탁센탄(Sitaxsentan; Sitaxentan; Thelin ...) | C18H15ClN2O6S2 |
옥사프로진(oxaprozin; Daypro; Deflam ...) | C18H15NO3 |
펜프로코우몬(PHENPROCOUMON; Phenprocoumarol; Liquamar ...) | C18H16O3 |
트라닐라스트(tranilast; Rizaben; Tranilastum ...) | C18H17NO5 |
록사핀(loxapine; Cloxazepine; Dibenzoazepine ...) | C18H18ClN3O |
세파만돌(cefamandole; Cefadole; Cefamandolum ...) | C18H18N6O5S2 |
세프트리악손(ceftriaxone; Biotrakson; Cefatriaxone ...) | C18H18N8O7S3 |
디에네스톨(dienestrol; Dehydrostilbestrol; Dienoestrol ...) | C18H18O2 |
펠로디핀(felodipine; Plendil; Perfudal ...) | C18H19Cl2NO4 |
클로자핀(clozapine; Leponex; Fazaclo ...) | C18H19ClN4 |
트리플루프로마진(triflupromazine; Fluopromazine; Siquil ...) | C18H19F3N2S |
온단세트론(ondansetron; Zofran; Zophren ...) | C18H19N3O |
로시글리타존(rosiglitazone; Avandia; Rosiglizole ...) | C18H19N3O3S |
세프프로질(cefprozil; Cefprozil anhydrous; Brisoral ...) | C18H19N3O5S |
세팔로글리신(Cefaloglycin; Cephaloglycine; CEPHALOGLYCIN ...) | C18H19N3O6S |
둘록세틴(duloxetine; Cymbalta; Yentreve ...) | C18H19NOS |
레보플록사신(LEVOFLOXACIN; Levaquin; Quixin ...) | C18H20FN3O4 |
미아세린(mianserin; Mianserine; Mianserina ...) | C18H20N2 |
니트레디핀(nitrendipine; Baypress; Bayotensin ...) | C18H20N2O6 |
메트딜라진(METHDILAZINE; Tacaryl; Methodilazine ...) | C18H20N2S |
디에틸스틸베스트롤(diethylstilbestrol; Stilbestrol; Distilbene ...) | C18H20O2 |
라베프라졸(rabeprazole; Rebeprazole sodium; 117976-89-3 ...) | C18H21N3O3S |
코데인(codeine; Methylmorphine; Codicept ...) | C18H21NO3 |
하이드로코돈(HYDROCODONE; Dihydrocodeinone; Hydrocodon ...) | C18H21NO3 |
옥시코돈(oxycodone; Dihydrone; Dihydroxycodeinone ...) | C18H21NO4 |
페녹시벤자민(phenoxybenzamine; Dibenyline; Dibenzyran ...) | C18H22ClNO |
데시프라민(desipramine; Norimipramine; Desmethylimipramine ...) | C18H22N2 |
시클리진(CYCLIZINE; Marezine; Nautazine ...) | C18H22N2 |
트리메프라진(trimeprazine; Methylpromazine; Alimemazine ...) | C18H22N2S |
에스트론(estrone; folliculin; Theelin ...) | C18H22O2 |
세포티암(cefotiam; Cefotiamum; Cefotiamum [INN-Latin] ...) | C18H23N9O4S3 |
오르페나드린(orphenadrine; Disipal; o-Methyldiphenhydramine ..._ | C18H23NO |
도부타민(dobutamine; racemic-Dobutamine; Dobutrex ...) | C18H23NO3 |
게네사(Genesa; ARBUTAMINE; Arbutaminum ...) | C18H23NO4 |
키트릴(Kytril; Granisetron base; Granisetronum [INN-Latin] ...) | C18H24N4O |
에스트라디올(estradiol; beta-Estradiol; 17beta-Estradiol ...) | C18H24O2 |
에스트리올(estriol; Oestriol; Estratriol ...) | C18H24O3 |
삭사글립틴(Saxagliptin; Onglyza; BMS-477118 ...) | C18H25N3O2 |
d-메토르판(d-Methorphan; dextromethorphan; Delsym ...) | C18H25NO |
클로로퀸(chloroquine; Aralen; Artrichin ...) | C18H26ClN3 |
하이드로클로로퀸(hydroxychloroquine; Oxichlorochinum; Oxychlorochin ...) | C18H26ClN3O |
디클로닌(dyclonine; Dyclocaine; Dyclocainum ...) | C18H27NO2 |
부피바카인(bupivacaine; Marcaine; Sensorcaine ...) | C18H28N2O |
레보부피바카인(Levobupivacaine; L(-)-Bupivacaine; (S)-bupivacaine) ... | C18H28N2O |
아세부톨롤(acebutolol; Acetobutolol; Neptal ...) | C18H28N2O4 |
밤부테롤(Bambuterol; Bambec; Bambuterolum ...) | C18H29N3O5 |
펜부톨롤(penbutolol; Betapressin; Levatol ...) | C18H29NO2 |
베탁솔롤(betaxolol; Betoptic; Betaxololum ...) | C18H29NO3 |
비소프롤롤(BISOPROLOL; Concor; Zebeta ...) | C18H31NO4 |
카나마이신(KANAMYCIN A; kanamycin; Kanamycin Base ...) | C18H36N4O11 |
제폴레스타트(ZOPOLRESTAT; CP-73850; 110703-94-1 ...) | C19H12F3N3O3S |
디쿠마롤(dicumarol; dicoumarol; Bishydroxycoumarin ...) | C19H12O6 |
아세노코우마롤(ACENOCOUMAROL; Acenocoumarin; Nicoumalone ...) | C19H15NO6 |
인도메타신(indomethacin; indometacin; Indocin ...) | C19H16ClNO4 |
워파린(warfarin; Coumafene; Coumadin ...) | C19H16O4 |
디클록사실린(dicloxacillin; Dicloxacycline; Dynapen ...) | C19H17Cl2N3O5S |
부토코나졸(Butoconazole; Butoconazolum; Butoconazol ...) | C19H17Cl3N2S |
플루클록사실린(Flucloxacillin; FLOXACILLIN; Floxapen ...) | C19H17ClFN3O5S |
프라제팜(prazepam; Demetrin; Lysanxia ...) | C19H17ClN2O |
올나프테이트(tolnaftate; Tinactin; Aftate ...) | C19H17NOS |
클록사실린(cloxacillin; Cloxacilline; Cloxacillinum ...) | C19H18ClN3O5S |
리바록사반(Rivaroxaban; Xarelto; 366789-02-8 ...) | C19H18ClN3O5S |
아디나졸람(ADINAZOLAM; Deracyn; Adinazolamum ...) | C19H18ClN5 |
데슬로라타딘(Desloratadine; Clarinex; Descarboethoxyloratadine ...) | C19H19ClN2 |
펜인다민(Phenindamine; Thephorin; Nolahist ...) | C19H19N |
옥사실린(oxacillin; Oxazocillin; MPI-penicillin ...) | C19H19N3O5S |
닐바디핀(nilvadipine; Escor; Nivadil ...) | C19H19N3O6 |
폴산(folic acid; Folate; Folvite ...) | C19H19N7O6 |
케토티펜(ketotifen; Ketotifene; Ketotifene [INN-French] ...) | C19H19NOS |
베자피브레이트(bezafibrate; Bezalip; Cedur ...) | C19H20ClNO4 |
파록세틴(paroxetine; Paxil; Aropax ...) | C19H20FNO3 |
페닐부타존(phenylbutazone; Butazolidin; Diphenylbutazone ...) | C19H20N2O2 |
피오글리타존(Pioglitazone; Actos; Pioglitazona ...) | C19H20N2O3S |
노르트립틸린(nortriptyline; Sensaval; Noritren ...) | C19H21N |
프로트립틸린(protriptyline; Amimetilina; Protryptyline ...) | C19H21N |
졸피뎀(zolpidem; Lorex; Zolpidemum [Latin] ...) | C19H21N3O |
이스라디핀(isradipine; DynaCirc; Lomir ...) | C19H21N3O5 |
피렌제핀(pirenzepine; Pirenzepin; Gastrozepin ...) | C19H21N5O2 |
프라조신(prazosin; Furazosin; Minipress ...) | C19H21N5O4 |
날록손(naloxone; l-Naloxone; n-Allylnoroxymorphone ...) | C19H21NO4 |
트라조돈(trazodone; Beneficat; Trazalon ...) | C19H22ClN5O |
스파플록사신(sparfloxacin; Zagam; CI-978 ...) | C19H22F2N4O3 |
그레파플록사신(Grepafloxacin; Raxar; Grepafloxacin [INN] ...) | C19H22FN3O3 |
가티플록사신(Gatifloxacin; Tequin; Zymar ...) | C19H22FN3O4 |
액티딜(Actidil; triprolidine; Myidyl ...) | C19H22N2 |
아세프로메타진(Acepromethazine; Aceprometazine; Aceprometazina ...) | C19H22N2OS |
클로미프라민(clomipramine; Chlorimipramine; Hydiphen ...) | C19H23ClN2 |
에르고메트린(Ergometrine; ERGONOVINE; Ergobasine ...) | C19H23N3O2 |
헤타실린(hetacillin; Versapen; Hetacillinum ...) | C19H23N3O4S |
트리메트렉세이트(trimetrexate; CI-898; Trimetrexatum [INN-Latin] ...) | C19H23N5O3 |
디페닐피랄린(diphenylpyraline; Allergen; Belfene ...) | C19H23NO |
레복세틴(Reboxetine; Esreboxetine; Davedax ...) | C19H23NO3 |
이미프라민(imipramine; Imidobenzyle; Melipramine ...) | C19H24N2 |
프라지콴텔(praziquantel; Biltricide; Droncit ...) | C19H24N2O2 |
라베탈롤(labetalol; Labetolol; Albetol ...) | C19H24N2O3 |
포르모테롤(formoterol; Oxis; Foradile ...) | C19H24N2O4 |
에토프로파진(ethopropazine; Parsidol; Profenmine ...) | C19H24N2S |
펜타미딘(pentamidine; Pentacarinat; 100-33-4 ...) | C19H24N4O2 |
세페핌(cefepime; Maxipime; Axepim ...) | C19H24N6O5S2 |
테스톨락톤(testolactone; Teslac; Fludestrin ...) | C19H24O3 |
보르테조미브(Bortezomib; PS-341; 179324-69-7 ...) | C19H25BN4O4 |
테라조신(terazosin; Terazosine; Flumarc ...) | C19H25N5O4 |
레발로르판(levallorphan; Naloxiphan; Lorfan ...) | C19H25NO |
페골리드(pergolide; Permax; Pergolidum [INN-Latin] ...) | C19H26N2S |
도페틸리드(Dofetilide; Tikosyn; Dofetilida ...) | C19H27N3O5S2 |
다피프라졸(Dapiprazole; Dapiprazol; Glamidolo ...) | C19H27N5 |
알푸조신(alfuzosin; Alfuzosinum; Alfusosine ...) | C19H27N5O4 |
펜타조신(pentazocine; Pentazocaine; Liticon ...) | C19H27NO |
테트라베나진(TETRABENAZINE; Nitoman; Rubigen ...) | C19H27NO3 |
테스토스테론(testosterone; Androderm; Testoderm ...) | C19H28O2 |
시크리민(cycrimine; Pagitane; Cicrimina ...) | C19H29NO |
프로시클리딘(procyclidine; Tricyclamol; Arpicolin ...) | C19H29NO |
디피베프린(dipivefrin; Dipivefrine; Propine ...) | C19H29NO5 |
옥산드롤론(OXANDROLONE; Oxandrin; Anavar ...) | C19H30O3 |
페린도프릴(PERINDOPRIL; Coversyl; ACEON ...) | C19H32N2O5 |
페르헥실린(PERHEXILINE; Perhexilene; 2-(2,2-Dicyclohexylethyl)piperidine ...) | C19H35N |
디시클로민(dicyclomine; Dicycloverin; Dicycloverine ...) | C19H35NO2 |
이오디파미드IODIPAMIDE; Adipiodone; Cholografin ... | C20H14I6N2O6 |
에트라비린(Etravirine; Intelence; TMC-125 ...) | C20H15BrN6O |
세르타코나졸(Sertaconazole; Sertaconazol [Spanish]; Sertaconazolum [Latin] ...) | C20H15Cl3N2OS |
트로바플록사신(Trovafloxacin; Trovan; TVFX ...) | C20H15F3N4O3 |
목사락탐(moxalactam; Latamoxef; Lamoxactam ...) | C20H20N6O9S |
페노피브레이트(fenofibrate; Lipanthyl; Antara ...) | C20H21ClO4 |
에시탈로프람(Escitalopram; (S)-Citalopram; S(+)-Citalopram ...) | C20H21FN2O |
시탈로프람(citalopram; Nitalapram; Cipram ...) | C20H21FN2O |
시클로벤자프린(cyclobenzaprine; Flexeril; Proheptatriene ...) | C20H21N |
알림타(Alimta; Pemetrexed [INN:BAN]; HSDB 7316 ...) | C20H21N5O6 |
세포라니드(CEFORANIDE; Precef; Ceforanido ...) | C20H21N7O6S2 |
아모디아퀸(amodiaquine; Amodiaquin; Camoquine ...) | C20H22ClN3O |
아자타딘(AZATADINE; Optimine; Azatadine maleate ...) | C20H22N2 |
메토트렉세이트(methotrexate; Amethopterin; Rheumatrex ...) | C20H22N8O5 |
아미트립틸린(amitriptyline; Damilen; Elavil ...) | C20H23N |
마프로틸린(maprotiline; Deprilept; Maprotylina [Polish] ...) | C20H23N |
날트렉손(naltrexone; Celupan; Vivitrex ...) | C20H23NO4 |
메틱사트(Methixart; Metixene; METHIXENE ...) | C20H23NS |
프로클로르페라진(prochlorperazine; Compazine; Prochlorperazin ...) | C20H24ClN3S |
디메틴딘(DIMETHINDENE; Dimetindene; Forhistal ...) | C20H24N2 |
리카이니드(Ricainid; INDECAINIDE; Ricainide ...) | C20H24N2O |
니솔디핀(nisoldipine; Sular; Nisocor ...) | C20H24N2O6 |
루칸톤(LUCANTHONE; Lucanthon; Tixantone ...) | C20H24N2OS |
프로피마진(propiomazine; Phenoctyl; Propionylpromethazine ...) | C20H24N2OS |
에티닐 에스트라디올(ethinyl estradiol; Ethynylestradiol; Ethinyloestradiol ...) | C20H24O2 |
엑스메스탄(EXEMESTANE; Aromasin; Exemestance ...) | C20H24O2 |
소베티롬(Sobetirome; GC-1; QRX-431 ...) | C20H24O4 |
암로디핀(amlodipine; Amlodis; Amlocard ...) | C20H25ClN2O5 |
리세르지드(Lysergide; Lysergamid; LYSERGIC ACID DIETHYLAMIDE ...) | C20H25N3O |
메틸에르고노빈(methylergonovine; Methylergobasin; Methylergometrin ...) | C20H25N3O2 |
티아가빈(tiagabine; Tiagabinum [INN-Latin]; Tiagabina [INN-Spanish] ...) | C20H25NO2S2 |
킬로밀라스트(Cilomilast; Ariflo; 153259-65-5 ...) | C20H25NO4 |
트리미프라민(trimipramine; Trimeprimine; Sapilent ...) | C20H26N2 |
리서라이드(LISURIDE; Lysuride; lisuride maleate ...) | C20H26N4O |
노르에씬드론(norethindrone; Norethisterone; Micronor ...) | C20H26O2 |
실로스타졸(cilostazol; Pletal; Pletaal ...) | C20H27N5O2 |
글리속세피드(Glisoxepide; Glisoxepid; Glisepin ...) | C20H27N5O5S |
트릴로스탄(Trilostane; Modrastane; Modrenal ...) | C20H27NO3 |
베반톨롤(Bevantolol; Bevantololum; Bevantololum [INN-Latin] ...) | C20H27NO4 |
옥시펜시클리민(oxyphencyclimine; Manir; Oxiphencycliminum ...) | C20H28N2O3 |
레미펜타닐(REMIFENTANIL; Remifentanyl; Ultiva ...) | C20H28N2O5 |
탐설로신(TAMSULOSIN; Flomax; 106133-20-4 ...) | C20H28N2O5S |
일로마스타트(Ilomastat; Galardin; GM 6001 ...) | C20H28N4O4 |
레티노산(Retinoic acid; tretinoin; Vitamin A acid ...) | C20H28O2 |
플루옥시메스테론(fluoxymesterone; Fluoxymestrone; Halotestin ...) | C20H29FO3 |
디부카인(dibucaine; Cinchocaine; Nupercainal ...) | C20H29N3O2 |
레티놀(retinol; Vitamin A; all-trans-Retinol ...) | C20H30O |
팀노돈산(Timnodonic acid; Eicosapentaenoic acid; Icosapent ...) | C20H30O2 |
트리헥시페니딜(trihexyphenidyl; Benzhexol; Triphenidyl ...) | C20H31NO |
아데플로어 디피복실(ADEFOVIR DIPIVOXIL; Hepsera; Preveon ...) | C20H32N5O8P |
디노프로스톤(Dinoprostone; Prostaglandin E2; PGE2 ...) | C20H32O5 |
디노프로스트(dinoprost; prostaglandin F2alpha; amoglandin ...) | C20H34O5 |
알프로스타딜(alprostadil; Prostaglandin E1; Caverject ...) | C20H34O5 |
이부틸리드(Ibutilide; Ibutilidum [INN-Latin]; Corvert ...) | C20H36N2O3S |
소라페니브(Sorafenib; Nexavar; 284461-73-0 ...) | C21H16ClF3N4O3 |
페르메트린(Permethrin; Transpermethrin; Elimite ...) | C21H20Cl2O3 |
플라보피리돌(Flavopiridol; Alvocidib; FLAVO ...) | C21H20ClNO5 |
지프라시돈(Ziprasidone; Geodon; Zeldox ...) | C21H21ClN4OS |
시프로헵타딘(CYPROHEPTADINE; Eiproheptadine; Periactin ...) | C21H21N |
나프티핀(Naftifine; Naftifin; Naftifina ...) | C21H21N |
나자로텐(tazarotene; Tazorac; Zorac ...) | C21H21NO2S |
나프실린(nafcillin; Naphcillin; Nafcilin-1 ...) | C21H22N2O5S |
랄티트렉스드(Raltitrexed; Tomudex; ZD1694 ...) | C21H22N4O6S |
플루라제팜(flurazepam; Dalmane; Dalmadorm ...) | C21H23ClFN3O |
할로페리돌(haloperidol; Haldol; Aloperidol ...) | C21H23ClFNO2 |
페리시아진(periciazine; PERICYAZINE; Propericiazine ...) | C21H23N3OS |
올로파타딘(Olopatadine; Patanol; Opatanol ...) | C21H23NO3 |
트리플루오페라진(trifluoperazine; Trifluperazine; Trifluoroperazine ...) | C21H24F3N3S |
목시플록사신(moxifloxacin; Vigamox; Avelox I.V. ...) | C21H24FN3O4 |
세티리진(cetirizine; Virlix; Cetryn ...) | C21H25ClN2O3 |
테르비나핀(terbinafine; Lamisil; Lamasil ...) | C21H25N |
퀘티아핀(quetiapine; Seroquel; 111974-69-7 ...) | C21H25N3O2S |
메즐로실린(MEZLOCILLIN; Mezlin; Mezlocilina ...) | C21H25N5O8S2 |
페르페나진(perphenazine; Trilafon; Perfenazine ...) | C21H26ClN3OS |
클레마스틴(clemastine; Mecloprodin; Meclastin ...) | C21H26ClNO |
니모디핀(nimodipine; Nimotop; Periplum ...) | C21H26N2O7 |
메소리다진(mesoridazine; Lidanar; Serentil ...) | C21H26N2OS2 |
티오리다진(thioridazine; Mellaril; Melleril ...) | C21H26N2S2 |
메스트라놀(mestranol; Devocin; Norquen ...) | C21H26O2 |
프레드니손(prednisone; Deltasone; Meticorten ...) | C21H26O5 |
하이드록시진(hydroxyzine; Hychotine; Hydroxine ...) | C21H27ClN2O2 |
트리암시놀론(triamcinolone; Fluoxyprednisolone; Aristocort ...) | C21H27FO6 |
바캄피실린(bacampicillin; Penglobe; Bacampicilline ...) | C21H27N3O7S |
글리피지드(glipizide; Glucotrol; Glydiazinamide ...) | C21H27N5O4S |
디페니돌(Difenidol; DIPHENIDOL; Vontrol ...) | C21H27NO |
메타돈(methadone; Adanon; Dolophine ...) | C21H27NO |
프로파페논(propafenone; Rythmol; Propafenona ...) | C21H27NO3 |
레보노르게스트렐(Levonorgestrel; Mirena; D-Norgestrel ...) | C21H28O2 |
디드로게스테론(dydrogesterone; Isopregnenone; Hydrogesterone ...) | C21H28O2 |
프레드니솔론(prednisolone; Meticortelone; Metacortandralone ...) | C21H28O5 |
알도스테론(ALDOSTERONE; Aldocortin; Electrocortin ...) | C21H28O5 |
플루드로코르티손(fludrocortisone; Fluohydrisone; Fluorocortisol ...) | C21H29FO5 |
디소피라미드(disopyramide; Dicorantil; Ritmodan ...) | C21H29N3O |
비페리덴(biperiden; Akineton; Biperidene ...) | C21H29NO |
드로나비놀(Dronabinol; Marinol; Deltanyne ...) | C21H30O2 |
프로게스테론(progesterone; Crinone; Luteohormone ...) | C21H30O2 |
하이드로코르티손(hydrocortisone; Cortisol; Cortef ...) | C21H30O5 |
리시노프릴(lisinopril; Prinivil; Zestril ...) | C21H31N3O5 |
부스피론(buspirone; Ansial; Buspirona ...) | C21H31N5O2 |
알펜타닐(ALFENTANIL; Alfentanyl; Alfenta ...) | C21H32N6O3 |
옥시페노늄(oxyphenonium; Methacin; Oxiphenonum ...) | C21H34NO3+ |
헤마베이트(Hemabate; C21H36O5; 15-Methyl-PGF2alpha ...) | C21H36O5 |
크로트리마졸(clotrimazole; Lotrimin; Mycelex ...) | C22H17ClN2 |
비포나졸(bifonazole; Mycospor; Trifonazole ...) | C22H18N2 |
릴피브린(Rilpivirine; TMC278; TMC 278 ...) | C22H18N6 |
타달라필(Tadalafil; Cialis; Tadanafil ...) | C22H19N3O4 |
리모나반트(Rimonabant; Acomplia; Zimulti ...) | C22H21Cl3N4O |
시나칼셋(Cinacalcet; 226256-56-0; Cinacalcet [INN] ...) | C22H22F3N |
드로페리돌(droperidol; Droleptan; Inapsine ...) | C22H22FN3O2 |
세프타지딤(ceftazidime; Fortaz; ceftazidima ...) | C22H22N6O7S2 |
포도필로톡신(podophyllotoxin; Podofilox; Condylox ...) | C22H22O8 |
로라타딘(loratadine; Claritin; Loratidine ...) | C22H23ClN2O2 |
로사르탄(losartan; Lortaan; Hyzaar ...) | C22H23ClN6O |
네스부비르(Nesbuvir; HCV-796; Nesbuvir (USAN) ...) | C22H23FN2O5S |
에르로티닙(Erlotinib; 183321-74-6; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine ...) | C22H23N3O4 |
반데타닙(Vandetanib; Zactima; 443913-73-3 ...) | C22H24BrFN4O2 |
게피티닙(Gefitinib; Iressa; 184475-35-2 ...) | C22H24ClFN4O3 |
아젤라스틴(azelastine; Azelastinum [INN-Latin]; Azelastina [INN-Spanish] ...) | C22H24ClN3O |
돔페리돈(domperidone; Motilium; Nauzelin ...) | C22H24ClN5O2 |
주클로펜틱솔(Zuclopenthixol; Clopixol; Zuclopentixol [Spanish] ...) | C22H25ClN2OS |
네비볼롤(Nebivolol; Nebilet; Lobivon ...) | C22H25F2NO4 |
모리시진(MORICIZINE; Moracizine; Ethmozine ...) | C22H25N3O4S |
에르타페넴(Ertapenem; Invanz; Ertapenem (INN) ...) | C22H25N3O7S |
타미바로텐(Tamibarotene; Am 80; Tamibaro ...) | C22H25NO3 |
다사티닙(Dasatinib; Sprycel; BMS-354825 ...) | C22H26ClN7O2S |
플루페나진(FLUPHENAZINE; Triflumethazine; Fluorfenazine ...) | C22H26F3N3OS |
엘레트립탄(Eletriptan; Relpax; eletriptanum ...) | C22H26N2O2S |
딜티아젬(diltiazem; Cardizem; Anoheal ...) | C22H26N2O4S |
시프로테론(cyproterone; Gen-Cyproterone; CyPat ...) | C22H27ClO3 |
수니티닙(Sunitinib; Sutent; SU-11248 ...) | C22H27FN4O2 |
다나졸(danazol; Danocrine; Cyclomen ...) | C22H27NO2 |
아미넵틴(Amineptine; Amineptin; Amineptino ...) | C22H27NO2 |
펜타닐(fentanyl; Duragesic; Fentanest ...) | C22H28N2O |
아닐레리딘(ANILERIDINE; Alidine; Leritin ...) | C22H28N2O2 |
에토니타젠(Etonitazene; Etonitazine; Etonitazinum ...) | C22H28N4O3 |
미톡산트론(mitoxantrone; Mitozantrone; Dihydroxyanthraquinone ...) | C22H28N4O6 |
델라비르딘(Delavirdine; Rescriptor; 136817-59-9 ...) | C22H28N6O3S |
데속시메타손(desoximetasone; Topicort; Desoximetasona ...) | C22H29FO4 |
플루오로메톨론(fluorometholone; Oxylone; Fluormetholone ...) | C22H29FO4 |
덱사메타손(dexamethasone; Maxidex; Dexamethazone ...) | C22H29FO5 |
파라메타손(paramethasone; Cassenne; Cortiden ...) | C22H29FO5 |
베타메타손(betamethasone; Flubenisolone; Betadexamethasone ...) | C22H29FO5 |
티에틸파라진(thiethylperazine; Torecan; ETHYLTHIOPERAZINE ...) | C22H29N3S2 |
클로르헥시딘(chlorhexidine; Tubulicid; Hexadol ...) | C22H30Cl2N10 |
아프린딘(APRINDINE; Aprinidine; Aprindin ...) | C22H30N2 |
서펜타닐(SUFENTANIL; Chronogesic; Sufentanyl ...) | C22H30N2O2S |
스피라프릴(Spirapril; Renormax; Sandopril ...) | C22H30N2O5S2 |
실데나필(sildenafil; Revatio; 139755-83-2 ...) | C22H30N6O4S |
데소게스트렐(DESOGESTREL; Cerazette; desogen ...) | C22H30O |
메틸프레드니솔론(methylprednisolone; Medrol; Medrone ...) | C22H30O5 |
실라자프릴(cilazapril; Inhibace; Cilazaprilum [Latin] ...) | C22H31N3O5 |
옥시부티닌(oxybutynin; Oxytrol; Ditropan ...) | C22H31NO3 |
벤즈퀴나미드(benzquinamide; Quantril; Emete-con ...) | C22H32N2O5 |
메드리손(medrysone; Hydroxymesterone; Medritonic ...) | C22H32O3 |
테스토스테론 프로피오네이트(testosterone propionate; Agovirin; Testex ...) | C22H32O3 |
포르스콜린(forskolin; Colforsin; Coleonol ...) | C22H34O7 |
티로피반(tirofiban; Aggrastat; Tirofiban [BAN:INN] ...) | C22H36N2O5S |
미소프로스톨(misoprostol; Cytotec; Arthrotec ...) | C22H38O5 |
아미카신(amikacin; Amicacin; Amikavet ...) | C22H43N5O13 |
1-도코사놀(1-DOCOSANOL; Behenyl alcohol; Docosanol ...) | C22H46O |
브레퀴나르(Brequinar; 96187-53-0; brequinarum [Latin] ...) | C23H15F2NO2 |
설핀피라존(sulfinpyrazone; Sulphinpyrazone; Anturane ...) | C23H20N2O3S |
클로로트리아니센(chlorotrianisene; Chlortrianisestrol; Chlortrianizen ...) | C23H21ClO3 |
타소사르탄(TASOSARTAN; 145733-36-4; Verdia ...) | C23H21N7O |
토포테칸(topotecan; Hycamtin; Hycamptamine ...) | C23H23N3O5 |
독사조신(doxazosin; Doxazosinum; Doxazosina ...) | C23H25N5O5 |
아리피프라졸(Aripiprazole; Abilify; Abilitat ...) | C23H27Cl2N3O2 |
리스페리돈(risperidone; Risperdal; Risperidal ...) | C23H27FN4O2 |
팔리페리돈(Paliperidone; Invega; 9-Hydroxyrisperidone ...) | C23H27FN4O3 |
부테나핀(butenafine; Butenafina; Butenafinum ...) | C23H27N |
피페라실린(piperacillin; Pipracil; Pipercillin ...) | C23H27N5O7S |
글리부리드(glyburide; Glibenclamide; Glybenclamide ...) | C23H28ClN3O5S |
시나루카스트(Cinalukast; CHEBI:126598; Cinalukast [USAN:INN] ...) | C23H28N2O3S |
포라사르탄(Forasartan; Forasartan (USAN/INN); UNII-065F7WPT0B ...) | C23H28N8 |
시사프리드(cisapride; Propulsid; Acenalin ...) | C23H29ClFN3O4 |
틸로틱센(Tiotixene; Navane; cis-Thiothixene ...) | C23H29N3O2S2 |
메파크린(mepacrine; quinacrine; atabrine ...) | C23H30ClN3O |
프로판텔린(propantheline; Propanthelinium; Propanthelinum ...) | C23H30NO3+ |
메타딜 아세테이트(Methadyl acetate; Acetylmethadol; ALPHACETYLMETHADOL...) | C23H31NO2 |
레바세틸메타돌(Levacetylmethadol; Levomethadyl acetate; LAAM ...) | C23H31NO2 |
노르게스티메이트(NORGESTIMATE; Dexnorgestrel acetime; Ortho-Prefest ...) | C23H31NO3 |
마이코페놀레이트 모페틸(mycophenolate mofetil; CellCept; Munoloc ...) | C23H31NO7 |
라미프릴(ramipril; Tritace; Altace ...) | C23H32N2O5 |
바르데나필(Vardenafil; Levitra; 224785-90-4 ...) | C23H32N6O4S |
피나스테라이드(finasteride; Proscar; Propecia ...) | C23H36N2O2 |
프라바스타틴(pravastatin; Pravastatine [French]; Pravastatinum [Latin] ...) | C23H36O7 |
파로모마이신(paromomycin; Aminosidin; Paramomycin Sulfate ...) | C23H45N5O14 |
네오마이신(neomycin; NEOMYCIN B; Framycetin ...) | C23H46N6O13 |
칸데사르탄candesartan; Blopress; 139481-59-7 ... | C24H20N6O3 |
에제티미브(Ezetimibe; Zetia; Ezetrol ...) | C24H21F2NO3 |
에리박사반(eribaxaban; PD-0348292; 536748-46-6 ...) | C24H22ClFN4O4 |
알레글리타자르(Aleglitazar; Aleglitazar (USAN); 475479-34-6 ...) | C24H23NO5S |
플라복세이트(flavoxate; Urispas; Flavoxato ...) | C24H25NO4 |
니세로골린(nicergoline; Nicotergoline; Nimergoline ...) | C24H26BrN3O3 |
세르틴돌(SERTINDOLE; SerLect; Serdolect ...) | C24H26ClFN4O |
카르베디롤(carvedilol; Coreg; Carvedilolum ...) | C24H26N2O4 |
트로글리타존(troglitazone; Rezulin; Prelay ...) | C24H27NO5S |
베나제프릴(benazepril; Benazeprilum [Latin]; benazapril ...) | C24H28N2O5 |
벡사로텐(Bexarotene; Targretin; Targrexin ...) | C24H28O2 |
발사르탄(valsartan; Diovan; 137862-53-4 ...) | C24H29N5O3 |
도네페질(donepezil; Eranz; 120014-06-4 ...) | C24H29NO3 |
플루오시놀론(FLUOCINOLONE ACETONIDE; Synandone; Fluonid ...) | C24H30F2O6 |
독사프람(doxapram; Dopram; 309-29-5 ...) | C24H30N2O2 |
드로스피레논(Drospirenone; Dihydrospirorenone; Dehydospirorenone ...) | C24H30O3 |
로테프레드놀(Loteprednol etabonate; Lotemax; Alrex ...) | C24H31ClO7 |
플루니솔리드(flunisolide; Nasalide; Aerobid ...) | C24H31FO6 |
카르페나진(Carphenazine; Carfenazine; Carphenazin ...) | C24H31N3O2S |
에티노디올(ETHYNODIOL DIACETATE; Continuin; Femulen ...) | C24H32O4 |
스피로놀락톤(spironolactone; Aldactone; Verospiron ...) | C24H32O4S |
데소니드(DESONIDE; DesOwen; Tridesilon ...) | C24H32O6 |
라놀라진(RANOLAZINE; Ranexa; 95635-55-5 ...) | C24H33N3O4 |
베프리딜(bepridil; Bepadin; Vascor ...) | C24H34N2O |
트라돌라프린(trandolapril; Mavik; Gopten ...) | C24H34N2O5 |
글리메피리드(glimepiride; Amaryl; Amarel ...) | C24H34N4O5S |
Org-6216; Vexol (TN); AC1NSKKX ... | C24H34O3 |
나빌론(Nabilone; Cesamet; 51022-71-0 ...) | C24H36O3 |
로바스타틴(lovastatin; mevinolin; Mevacor ...) | C24H36O5 |
디피리다몰(dipyridamole; Persantin; Curantyl ...) | C24H40N8O4 |
케노데옥시콜산(chenodeoxycholic acid; Chenodiol; Chenix ...) | C24H40O4 |
우르소디올(ursodiol; URSODEOXYCHOLIC ACID; Actigall ...) | C24H40O4 |
아픽사반(Apixaban; 503612-47-3; Eliquis ...) | C25H25N5O4 |
메클리진(meclizine; Meclozine; Parachloramine ...) | C25H27ClN2 |
이르베사르탄(irbesartan; Avapro; Aprovel ...) | C25H28N6O |
아미오다론(amiodarone; Cordarone; Amiodarona ...) | C25H29I2NO3 |
퀴나프릴(quinapril; Quinaprilum [Latin]; Quinaprilum ...) | C25H30N2O5 |
플루티카손(FLUTICASONE PROPIONATE; Cutivate; Flonase ...) | C25H31F3O5S |
클로베타솔 프로피오네이트(CLOBETASOL PROPIONATE; Clobex; Embeline ...) | C25H32ClFO5 |
네파조돈(nefazodone; Nefazodonum [Latin]; Nefazodona [Spanish] ...) | C25H32ClN5O2 |
퀴네스트롤(QUINESTROL; Estrovis; Estrovister ...) | C25H32O2 |
암프레나비르(amprenavir; Agenerase; Prozei ...) | C25H35N3O6S |
포삼프레나비르(Fosamprenavir; Telzir; Fosamprenavir [INN] ...) | C25H36N3O9PS |
우데나필(Udenafil; Zydena; DA-8159 ...) | C25H36N6O4S |
살메테롤(Salmeterol; Astmerole; Serevent ...) | C25H37NO4 |
비마토프로스트(Bimatoprost; Lumigan; Latisse ...) | C25H37NO4 |
플루나리진(flunarizine; Sibelium; Flunarizinum [INN-Latin] ...) | C26H26F2N2 |
이다루비신(IDARUBICIN; Idamycin; idarubicin hydrochloride ...) | C26H27NO9 |
케토덤(Ketoderm; Panfungol; Orifungal M ...) | C26H28Cl2N4O4 |
주클로미펜(Zuclomiphene; Cisclomiphene; Zuclomifene ...) | C26H28ClNO |
토레미펜(toremifene; Acapodene; Farestone ...) | C26H28ClNO |
시나리진(cinnarizine; Stugeron; Dimitronal ...) | C26H28N2 |
알미트린(ALMITRINE; Almitrin; Vectarion ...) | C26H29F2N7 |
레보카바스틴(levocabastine; Livostin; Levocabastinum [Latin] ...) | C26H29FN2O2 |
니카르디핀(nicardipine; Nicardipinum [INN-Latin]; Nicardipino [INN-Spanish] ...) | C26H29N3O6 |
타목시펜(tamoxifen; Crisafeno; Diemon ...) | C26H29NO |
할로판트린(Halofantrine; Halfan; Halofantrine [USAN] ...) | C26H30Cl2F3NO |
테르코나졸(terconazole; Triaconazole; Terazol ...) | C26H31Cl2N5O3 |
디플로라손 디아세테이트(Diflorasone diacetate; Florone; Psorcon ...) | C26H32F2O7 |
플루오시노니드(fluocinonide; Lidex; Fluocinolide ...) | C26H32F2O7 |
세리바스타틴(cerivastatin; Lipobay; cerivastatin acid ...) | C26H34FNO5 |
트라보프로스트(Travoprost; Travatan; Travatan Z ...) | C26H35F3O6 |
카베르골린(cabergoline; Dostinex; Cabaser ...) | C26H37N5O2 |
머피로신(Mupirocin; Pseudomonic acid; Bactroban ...) | C26H44O9 |
클로파지민(clofazimine; Lamprene; Lampren ...) | C27H22Cl2N4 |
보센탄(Bosentan; Tracleer; 147536-97-8 ...) | C27H29N5O6S |
다우노루비신(daunorubicin; Daunomycin; Rubidomycin ...) | C27H29NO10 |
독소루비신(doxorubicin; Adriamycin; Adriblastina ...) | C27H29NO11 |
글리퀴돈(Gliquidone; Glurenorm; glikvidon ...) | C27H33N3O6S |
모엑시프릴(MOEXIPRIL; Moexiprilum [INN-Latin]; 103775-10-6 ...) | C27H34N2O7 |
로코르텐(Locorten; FLUMETHASONE PIVALATE; Locacorten ...) | C27H36F2O6 |
레파글리니드(Repaglinide; Prandin; NovoNorm ...) | C27H36N2O4 |
다루나비르(Darunavir; Prezista; TMC-114 ...) | C27H37N3O7S |
베라파밀(VERAPAMIL; Iproveratril; Cordilox ...) | C27H38N2O4 |
파리칼시톨(Paricalcitol; Zemplar; 19-Nor-1alpha,25-dihydroxyvitamin D2 ...) | C27H44O3 |
라록시펜(raloxifene; Keoxifene; Raloxifenum [Latin] ...) | C28H27NO4S |
아다팔렌(ADAPALENE; Differin; Adaferin ...) | C28H28O3 |
피목지드(pimozide; Orap; Opiran ...) | C28H29F2N3O |
다리페나신(Darifenacin; Emselex; CHEBI:391960 ...) | C28H30N2O2 |
아스테미졸(astemizole; Hismanal; Alermizol ...) | C28H31FN4O |
부킬리진(Buclizine; Vibazine; Histabuticine ...) | C28H33ClN2 |
암시노니드(amcinonide; Cyclocort; amcinonida ...) | C28H35FO7 |
플러릭사포르(Plerixafor; Mozobil; AMD3100 ...) | C28H54N8 |
라파티닙(Lapatinib; Tykerb; 231277-92-2 ...) | C29H26ClFN4O4S |
올메사르탄 메독시밀(Olmesartan medoxomil; Benicar; 144689-63-4 ...) | C29H30N6O6 |
플루스피릴렌(Fluspirilene; Redeptin; Imap ...) | C29H31F2N3O |
이마티닙(Imatinib; 152459-95-5; sti-571 ...) | C29H31N7O |
에토포시드(etoposide; VePesid; Lastet ...) | C29H32O13 |
로페라미드(loperamide; Ioperamide; Loperacap ...) | C29H33ClN2O2 |
미페프리스톤(mifepristone; Mifeprex; Mifegyne ...) | C29H35NO2 |
미베프라딜(Mibefradil; Posicor; Mibefradil [INN:BAN] ...) | C29H38FN3O3 |
마라비록(Maraviroc; Celsentri; Selzentry ...) | C29H41F2N5O |
카녹사트릴(Candoxatril; CHEBI:3353; AC1NSFYL ...) | C29H41NO7 |
올리스타트(orlistat; Xenical; Tetrahydrolipstatin ...) | C29H53NO5 |
리비도마이신 A(lividomycin A; Lividomycin; Quintomycin B ...) | C29H55N5O18 |
디페녹실레이트(DIPHENOXYLATE; Difenossilato [DCIT]; Difenoxilato ...) | C30H32N2O2 |
알리스키렌(Aliskiren; Rasilez; Tekturna ...) | C30H53N3O6 |
티프라나비르(Tipranavir; Aptivus; PNU-140690 ...) | C31H33F3N2O5S |
자피르루카스트(zafirlukast; Accolate; 107753-78-6 ...) | C31H33N3O6S |
도라마피모드(Doramapimod; BIRB-796; BIRB 796 ...) | C31H37N5O3 |
프로부콜(probucol; Lorelco; Biphenabid ...) | C31H48O2S2 |
푸시디산(fusidic acid; Fusidine; Ramycin ...) | C31H48O6 |
코니밥탄(Conivaptan; YM 087; YM087 ...) | C32H26N4O2 |
데세르피딘(DESERPIDINE; Harmonyl; Raunormine ...) | C32H38N2O8 |
펙소페나딘(fexofenadine; Carboxyterfenadine; Terfenadine-COOH ...) | C32H39NO4 |
브로모크립틴(bromocriptine; Bromocriptin; Bromocryptine ...) | C32H40BrN5O5 |
테르페나딘(terfenadine; Seldane; Triludan ...) | C32H41NO2 |
넬피나비르(nelfinavir; 159989-64-7; AG1343 ...) | C32H45N3O4S |
풀베스트란트(Fulvestrant; Faslodex; ICI 182,780 ...) | C32H47F5O3S |
텔미사르탄(Telmisartan; Micardis; Pritor ...) | C33H30N4O2 |
아토르바스타틴(atorvastatin; Cardyl; Sotis ...) | C33H35FN2O5 |
에르고타민(Ergotamin; Ergostat; Gynergen ...) | C33H35N5O5 |
디하이드로에르고타민(dihydroergotamine; Ergomimet; Orstanorm ...) | C33H37N5O5 |
이리노테칸(irinotecan; Camptosar; (+)-Irinotecan ...) | C33H38N4O6 |
레세르핀(reserpine; Serpasil; Serpalan ...) | C33H40N2O9 |
몬텔루카스트(montelukast; Montair; Singular ...) | C35H36ClNO3S |
이트라코나졸(itraconazole; Sporanox; Oriconazole ...) | C35H38Cl2N8O4 |
레시나민(rescinnamine; Rescinnamin; Moderil ...) | C35H42N2O9 |
에날키렌(ENALKIREN; Enalquireno; Abbott-64662 ...) | C35H56N6O6 |
레르카니디핀(Lercanidipine; Lercanidipine [INN]; masnidipine ...) | C36H41N3O6 |
인디나비르(indinavir; Compound J; Crixivan ...) | C36H47N5O4 |
투보쿠라린(tubocurarine; d-Tubocurarine; Tubocurarin ...) | C37H41N2O6+ |
로피나비르(Lopinavir; Aluviran; ABT-378 ...) | C37H48N4O5 |
리토나비르(ritonavir; Norvir; Norvir Sec ...) | C37H48N6O5S2 |
에리트로마이신(erythromycin; Erythromycin A; Erymax ...) | C37H67NO13 |
아타자나비르(Atazanavir; Latazanavir; Zrivada ...) | C38H52N6O7 |
디지톡신(digitoxin; Digitoxoside; Crystodigin (TN) ...) | C41H64O13 |
트롤린도마이신(TROLEANDOMYCIN; Triacetyloleandomycin; Matromicina ...) | C41H67NO15 |
류코마이신 A3(Leucomycin A3; Turimycin A5; josamycin ...) | C42H69NO15 |
리팍시민(Rifaximin; Rifaxidin; Xifaxan ...) | C43H51N3O11 |
도세탁셀(docetaxel; Taxotere; Docetaxel anhydrous ...) | C43H53NO14 |
빈데신(vindesine; Desacetylvinblastine amide; Vindesin ...) | C43H55N5O7 |
비노렐빈(vinorelbine; Navelbine base; Navelbine ...) | C45H54N4O8 |
빈크리스틴(vincristine; Leurocristine; 22-Oxovincaleukoblastine ...) | C46H56N4O10 |
리파부틴(RIFABUTIN; Ansamycin; Mycobutin ...) | C46H62N4O11 |
탁솔(TAXOL; paclitaxel; Abraxane ...) | C47H51NO14 |
프리프틴(Priftin; RIFAPENTINE; Cyclopentyl rifampin ...) | C47H64N4O12 |
암포테리신 b(amphotericin b; Amphotericin; Ambisome ...) | C47H73NO17 |
테를리프레신(Terlipressin; glypressin; Lucassin ...) | C52H74N16O15S2 |
아니둘라펀진(Anidulafungin; Eraxis; Ecalta ...) | C58H73N7O17 |
미바쿠리움(Mivacurium; MIVACURIUM CHLORIDE; AC1NQXXZ ...) | C58H80N2O14+2 |
Claims (31)
- 식물 물질로부터 유래되고 적어도 50 질량%의 바이오-기반(bio-based) 탄소를 포함하는 세티리진(cetirizine)의 약학적 유효량을, 이를 필요로 하는 환자에게 투여하는 단계를 포함하는 질병 상태를 치료하는 방법.
- 제1항에 있어서, 상기 세티리진의 20개의 탄소 원자들 중 12 또는 13개가 바이오-기반인 것인, 질병 상태를 치료하는 방법.
- 제1항 또는 제2항에 있어서, 투여용법에 있어서 상기 세티리진이 적어도 5일에 걸쳐 수 회분 이상 투여되고, 환자 순응도(patient compliance)가 적어도 20%까지 증가되는 것인, 질병 상태를 치료하는 방법.
- 20개의 탄소 원자들 중 적어도 12개가 바이오-기반인 세티리진을 포함하는 약학적 활성 화합물.
- 식물 물질로부터 유래되고 적어도 50 질량%의 바이오-기반 탄소를 포함하는 화합물의 약학적 유효량을, 이를 필요로 하는 환자에게 투여하는 단계를 포함하고; 상기 화합물은 클로르헥시딘 (클로르헥사메드 포르테) {Chlorhexidine(chlorhexamed forte)}, 암브록솔 (뮤코솔반) {Ambroxol (mucosolvan)}, 비사코딜 (듀코락스) {Bisacodyl (Ducolax)}, 자일로메타졸린 (올린쓰) {Xylomethazoline (Olynth)}, 디클로페낙 (포르테 볼타렌) {Diclofenac (forte voltaren)}, 클로트리마졸 (카네스텐) {Clotrimazole (canesten)}, 오메프라졸 (오메프 헥살) {Omeprazole (omep Hexal)}, 플루르비프로펜 (도벤단) {(Flurbiprofen (Dobendan)}, 나프록센 (돌로민) {Naproxen (Dolormin)}, 독실아민 (호가) {Doxilamine (Hoggar)}, 로페라미드 (Loperamide) 및 이부프로펜 (Ibuprofen)인 것인, 질병 상태를 치료하는 방법.
- 적어도 일부가 바이오 매스로부터 유래되는 약학적 활성 화합물.
- 제6항에 있어서, 하나 이상의 방향족기를 포함하고, 화합물의 상기 하나 이상의 방향족기는 바이오매스로부터 유래되는 것인, 약학적 활성 화합물.
- 제7항에 있어서, 상기 전체 화합물은 바이오매스로부터 유도되는 것인, 약학적 활성 화합물.
- 살아있는 유기체의 14C : 12C 동위 원소 비율과 유사한 14C : 12C 동위 원소 비율을 갖는 약학적 활성 화합물.
- 약 1조분의 1의 14C 함량을 갖는 표 1의 목록으로부터 선택된 약학적 활성 화합물.
- 제6항에 있어서, 상기 화합물은 란소프라졸(lansoprazole) 또는 메펜터민(mephentermine)인 것인, 약학적 활성 화합물.
- 제1항 내지 제3항 중 어느 한 항에 따른 방법은 알레르기 증상의 치료를 위한 것인, 질병 상태를 치료하는 방법.
- 제6항 내지 제10항 중 어느 한 항에 따른 화합물을 적어도 하나 포함하는 약학 조성물.
- 제13항에 있어서, 적어도 하나의 약학적으로 허용 가능한 부형제를 더 포함하는 것인, 약학 조성물.
- 제13항에 있어서, 적어도 2개의 약학적 활성 화합물을 포함하는 것인, 약학 조성물.
- 제13항에 따른 조성물을, 이를 필요로 하는 환자에게 투여하는 단계를 포함하는 질환 상태를 치료하는 방법.
- 제13항에 따른 조성물을, 이를 필요로 하는 환자에게 투여하는 단계를 포함하는 질환 상태를 치료하는 방법.
- 제14항에 따른 조성물을, 이를 필요로 하는 환자에게 투여하는 단계를 포함하는 질환 상태를 치료하는 방법.
- 제1항 내지 제3항 및 제16항 내지 제18항 중 어느 한 항에 있어서, 하나 이상의 약학적 활성 화합물이 적어도 일부가 바이오 매스로부터 유래된 것임을 환자가 아는 것인, 질환 상태를 치료하는 방법.
- 제19항에 있어서, 환자 순응도(patient compliance)가 개선되는 것인, 질환 상태를 치료하는 방법.
- 약학적 투여용법으로 환자 순응도(patient compliance)를 개선하는 방법에 있어서, 상기 투여용법에서 적어도 일부가 바이오매스로부터 유래된 약학적 활성 화합물을 투여하는 단계를 포함하여 구성되는, 약학적 투여용법으로 환자 순응도를 개선하는 방법.
- 제21항에 있어서, 상기 투여용법이 적어도 3일에 걸친 다중 투약을 포함하는 것인, 약학적 투여용법으로 환자 순응도를 개선하는 방법.
- 약학적 투여용법으로 환자 순응도(patient compliance) 개선용 물질 X에 있어서, 상기 물질 X는 클로르헥시딘 (클로르헥사메드 포르테) {Chlorhexidine(chlorhexamed forte)}, 암브록솔 (뮤코솔반) {Ambroxol (mucosolvan)}, 세티리진 (헥살) {Cetirizine (Hexal)}, 비사코딜 (듀코락스) {Bisacodyl (Ducolax)}, 자일로메타졸린 (올린쓰) {Xylomethazoline (Olynth)}, 디클로페낙 (포르테 볼타렌) {Diclofenac (forte voltaren)}, 클로트리마졸 (카네스텐) {Clotrimazole (canesten)}, 오메프라졸 (오메프 헥살) {Omeprazole (omep Hexal)}, 플루르비프로펜 (도벤단) {(Flurbiprofen (Dobendan)}, 나프록센 (돌로민) {Naproxen (Dolormin)}, 독실아민 (호가) {Doxilamine (Hoggar)}, 로페라미드 (Loperamide) 및 이부프로펜 (Ibuprofen) 중 하나이고, 상기 물질 X는 적어도 10 질량%의 바이오-기반 탄소를 포함하는 것인, 약학적 투여용법으로 환자 순응도 개선용 물질 X.
- 탄소 원자의 10 내지 90 질량%가 바이오-기반인 약학적 활성 화합물.
- (i) 환자 집단의 환자에게 적어도 일부가 바이오매스로부터 유래된 약학적 활성 화합물을 투여하는 단계 및 (ii) 약학적 활성 화합물의 대사산물 중 적어도 하나의 대사산물의 동위 원소 비율을 평가하는 단계를 포함하는 환자 집단에서 약학적 활성 화합물의 대사를 평가하는 방법.
- 바이오매스-기반 방향족 화합물을 다른 유기 분자와 반응시켜 적어도 일부가 바이오매스-기반인 약학적 활성 분자를 생성하는 단계를 포함하는 바이오 매스 기반 약학적 활성 화합물의 제조방법.
- 제26항에 있어서, 상기 약학적 활성 화합물은 란소프라졸(lansoprazole), 세트리진(Cetirizine) 또는 메펜터민(mephentermine)인 것인, 바이오 매스 기반 약학적 활성 화합물의 제조방법.
- 제24항에 있어서, 상기 화합물은 클로르헥시딘(Chlorhexidine), 암브록솔(Ambroxol), 세티리진(Cetirizine), 비사코딜(Bisacodyl), 자일로메타졸린(Xylomethazoline), 디클로페낙(Diclofenac), 클로트리마졸(Clotrimazole), 오메프라졸(Omeprazole), 플루비프로펜(Flurbiprofen), 나프록센(Naproxen), 독실아민(Doxilamine),로페라미드(loperamide) 또는 이부프로펜(Ibuprofen)인 것인 약학적 활성 화합물.
- 일부 또는 전부가 바이오-기반인 탄소 원자를 포함하는 화합물에 있어서, 상기 화합물은 감염 치료 또는 대사 추적을 위한 클로르헥시딘 (Chlorhexidine), 호흡기 질환 치료를 위한 암브록솔 (Ambroxol), 알레르기 증상 치료를 위한 세티리진 (Cetirizine), 변비 치료를 위한 비사 코딜 (Bisacodyl), 코 막힘 치료를 위한 자일로메타졸린 (Xylomethazoline), 통증 및 염증성 질환 치료를 위한 디클로페낙 (Diclofenac), 진균 감염 치료를 위한 클로트리마졸 (Clotrimazole), 위궤양 및 위산 역류 치료를 위한 오메프라졸 (Omeprazole), 통증 및 관절염 치료를 위한 플루르비프로펜(Flurbiprofen), 발열 및 통증 치료를 위한 나프록센 (Naproxen), 알레르기 증상 치료를 위한 독실아민 (Doxilamine), 설사 치료를 위한 로페라미드 (loperamide), 열과 통증 치료를 위한 이부프로펜 (Ibuprofen)을 포함하고, 상기 약학적 활성 화합물은 적어도 10 질량%의 바이오-기반 탄소를 포함하고, 바람직하게는, 적어도 40%, 적어도 50%, 적어도 70% 또는 100% 바이오 기반 탄소를 포함하는 것인, 화합물.
- 제6항에 있어서, 상기 화합물은 22 개의 탄소 중 12 개가 바이오-기반인 클로르헥시딘 (Chlorhexidine), 13 개의 탄소 중 7 개가 바이오-기반인 암브록솔 (Ambroxol), 22 개의 탄소 중 12 개 또는 16 개가 바이오-기반인 비사코딜(Bisacodyl), 14 개의 탄소 중 8 개 또는 10 개가 바이오-기반인 자일로메타졸린 (Xylomethazoline), 14 개의 탄소 중 13 개가 바이오-기반인 디클로페낙 (Diclofenac), 20 개의 탄소 중 17 개가 바이오-기반인 클로트리마졸 (Clotrimazole), 17 개의 탄소 중 6 개가 바이오-기반인 오메프라졸 (Omeprazole), 15 개의 탄소 중 6 개 또는 12 개가 바이오-기반인 플루르비프로펜 (Flurbiprofen), 14 개의 탄소 중 10 개 또는 11 개가 바이오-기반인 나프록센 (Naproxen), 17 개의 탄소 중 6 개 또는 10 개가 바이오-기반인 독실아민 (Doxilamine), 29 개의 탄소 중 16 개, 18 개 또는 22 개가 바이오-기반인 로페라미드(loperamide)인 것인, 약학적 활성 화합물.
- 적어도 50%의 탄소가 식물로부터 유래되는 약학적 유효량의 이부프로펜을, 이를 필요로 하는 환자에게 투여하는 단계를 포함하는 질병 상태를 치료하는 방법.
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