KR20200116933A - 인간 심근세포에서 디스트로핀 돌연변이를 교정하기 위한 조성물 및 방법 - Google Patents

인간 심근세포에서 디스트로핀 돌연변이를 교정하기 위한 조성물 및 방법 Download PDF

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KR20200116933A
KR20200116933A KR1020207022943A KR20207022943A KR20200116933A KR 20200116933 A KR20200116933 A KR 20200116933A KR 1020207022943 A KR1020207022943 A KR 1020207022943A KR 20207022943 A KR20207022943 A KR 20207022943A KR 20200116933 A KR20200116933 A KR 20200116933A
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에릭 엔. 올슨
쳉주 롱
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더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템
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Abstract

본 개시내용은 뒤센 근 이영양증 (DMD) 치료 또는 예방을 필요로 하는 대상체에게 Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및 gRNA, 또는 gRNA를 코딩하는 서열을 투여하는 단계를 포함하고, 여기서, gRNA는 디스트로핀 유전자의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하는 것인, DMD 치료 또는 예방을 필요로 하는 대상체에서 DMD를 치료 또는 예방하는 방법을 제공한다. 투여는 대상체의 심근세포의 적어도 서브세트에서 디스트로핀 발현을 회복시키고, 적어도 부분적으로 또는 완전히 심수축성을 회복시킬 수 있다.

Description

인간 심근세포에서 디스트로핀 돌연변이를 교정하기 위한 조성물 및 방법
관련 출원에 대한 상호 참조
본 출원은 2018년 1월 31일 출원된 미국 특허 가출원 시리얼 번호 62/624,748의 우선권을 주장하며, 상기 특허는 그 전문이 본원에서 모든 목적을 위해 참조로 포함된다.
연방 정부 기금 지원 조항
본 발명은 미국 국립 보건원(National Institutes of Health: NIH)에 의해 부여된 보조금 번호 HL-130253, HL-077439, DK-099653, 및 AR-067294 하의 정부 지원으로 이루어졌다. 정부는 본 발명에 특정 권리를 갖는다.
서열 목록
본 출원은 ASCII 포맷으로 전자적으로 제출되고, 그의 전문이 본원에서 참조로 포함된 서열 목록을 포함한다. 2019년 1월 31일자로 작성된, 상기 ASCII 카피 파일명은 UTFDP0002WO.txt이고, 크기는 1,722,119 바이트이다.
본 개시내용의 분야
본 개시내용은 분자 생물학, 의약 및 유전학 분야에 관한 것이다. 더욱 특히, 본 개시내용은 엑손-스키핑 접근법을 사용하여 생체내에서 돌연변이를 교정하기 위한 유전자 편집을 위한 조성물 및 그의 용도에 관한 것이다.
배경
근 이영양증 (MD)은 운동을 제어하는 골격근의 점진적 약화 및 퇴행을 특징으로 하는 30개 초과의 유전 질환 중의 한 그룹이다. 뒤센 근 이영양증(Duchenne Muscular dystrophy: DMD)은 5,000명의 남아 중 대략 1명에서 발병되는, MD의 가장 중증 형태 중 하나이며, 점진적 근육 약화 및 조기성숙 사망을 특징으로 한다. 심근증 및 심부전은 DMD의 일반적이고, 치유불가능하며, 치명적인 특징이다. 본 질환은 세포 표면의 디스트로글리칸 복합체를 기초 세포골격과 연결하여 수축 동안에 근세포 막의 무결성을 유지하는 세포내 단백질인, 디스트로핀을 코딩하는 유전자 (DMD) 중의 돌연변이에 의해 유발된다. 디스트로핀 유전자 중의 돌연변이는 디스트로핀의 발현의 손실을 야기하여, 근막 허약 및 점전적인 근육 소모를 유발한다.
요약
CRISPR/Cas9를 이용한 유전자 편집은 질환 유발 돌연변이를 교정하거나, 또는 완화시키는 유망한 새로운 접근법이다. 뒤센 근 이영양증 (DMD)은 X-연관 디스트로핀 유전자 (DMD) 중의 3,000개 초과의 상이한 돌연변이에 의해 유발되는 심근 및 골격근의 치명적 퇴행과 연관이 있다. 상기 돌연변이는 대부분 "핫스팟"에 군집되어 있다. 본원 실시예에 기술되어 있는 바와 같이, 돌연변이 핫스팟 내의 또는 그 인접부에서의 가장 공통된 돌연변이체 또는 프레임 밖의 DMD 엑손의 스키핑을 잠재적으로 허용하는, 12개의 엑손 중의 보존적 RNA 스플라이스 부위를 폐기하는 삽입/결실 (indel) 돌연변이를 비상동성 말단 연결에 의해 도입할 수 있는 최적의 가이드 RNA에 대한 스크린을 수행하였다. 엑손 스키핑에 의한 DMD 돌연변이 교정은 본원에서 "근편집"으로 지칭한다. 개념 증명 연구에서, DMD 유전자 내에 큰 결실, 점 돌연변이, 또는 중복을 갖는 다수의 환자로부터의 대표적인 유도 만능성 줄기 세포에서 근편집이 수행되었고, 이는 유도 심근세포에서 디스트로핀 단백질 발현을 효율적으로 회복시켰다. 3차원의 조작된 심장 근육 (EHM)에서, DMD 돌연변이의 근편집이 디스트로핀 발현 및 상응하는 기계적 수축 장력을 회복시켰다. 심근세포의 서브세트만 (30 내지 50%)을 교정하는 것도 돌연변이체 EHM 표현형을 거의 정상에 가까운 제어 수준으로까지 구제하는 데에는 충분하였다. 따라서, 보존적 RNA 스플라이싱 수용자/공여자 부위를 폐기하고, 근편집을 통해 돌연변이체 또는 프레임 밖의 엑손을 스키핑하도록 스플라이싱 기구를 유도함으로써 질환의 근본적인 유전적 이유를 제거하여 DMD와 연관된 심장 이상을 교정할 수 있을 것으로 보인다.
따라서, 일부 실시양태에서, 본 개시내용은 심근세포를, Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및 gRNA, 또는 gRNA를 코딩하는 서열과 접촉시키는 단계를 포함하고, 여기서, gRNA는 디스트로핀 유전자의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하는 것인, 심근세포에서 돌연변이체 디스트로핀 유전자를 편집하는 방법을 제공한다.
본 개시내용은 또한 뒤센 근 이영양증 (DMD) 치료 또는 예방을 필요로 하는 대상체에게 Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및 gRNA, 또는 gRNA를 코딩하는 서열을 투여하는 단계를 포함하고, 여기서, gRNA는 디스트로핀 유전자의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하고; 여기서, 투여는 대상체의 심근세포의 적어도 10%에서 디스트로핀 발현을 회복시키는 것인, DMD 치료 또는 예방을 필요로 하는 대상체에서 DMD를 치료 또는 예방하는 방법을 제공한다.
본 개시내용은 또한 유도 만능성 줄기 세포 (iPSc)를, Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및 gRNA, 또는 gRNA를 코딩하는 서열과 접촉시키는 단계로서, 여기서, gRNA는 디스트로핀 유전자의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하는 것인 단계; iPSC를 심근세포로 분화시키는 단계; 및 심근세포를 뒤센 근 이영양증 (DMD) 치료 또는 예방을 필요로 하는 대상체에게 투여하는 단계를 포함하는, DMD 치료 또는 예방을 필요로 하는 대상체에서 DMD를 치료 또는 예방하는 방법을 제공한다.
본 개시내용의 방법에 따라 제조된 세포 (예컨대, 유도 만능성 줄기 세포 (iPSc) 또는 심근세포), 및 그의 조성물 또한 제공한다. 일부 실시양태에서, 세포는 디스트로핀 단백질을 발현한다.
Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및 gRNA, 또는 gRNA를 코딩하는 서열을 포함하는 유도 만능성 줄기 세포 (iPSc)로서, 여기서, gRNA는 디스트로핀 유전자의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하는 것인 유도 만능성 줄기 세포 (iPSc) 또한 제공한다.
본 명세서에서 사용되는 바, "하나"("a" 또는 "an")라는 것은 하나 이상의 것을 의미할 수 있다. 청구항(들)에서 사용되는 바, "포함하는"이라는 단어와 함께 사용하는 경우, "하나"라는 단어는 하나 또는 1개 초과를 의미할 수 있다.
청구범위에서 "또는"이라는 용어의 사용은, 달리 명확하게 명시되지 않는 한, 비록 본 개시내용은 단지 대안 및 "및/또는"만을 지칭하는 정의를 뒷받침하지만, 대안만을 지칭하거나, 또는 대안이 서로 배타적이라는 것을 지칭한다. 본원에서 사용되는 바, "또 다른"은 적어도 제2 이상을 의미한다.
본 출원 전체에 걸쳐, "약"이라는 용어는 값이 장치, 값을 측정하기 위해 사용된 방법, 또는 연구 대상체 중에 존재하는 것에 대한 고유한 오차 변동을 포함하는 것을 나타내는 데 사용된다. 이러한 고유한 변동은 언급된 값의 ±10%의 변동일 수 있다.
본 출원 전체에 걸쳐, 달리 명시되지 않는 한, 뉴클레오티드 서열은 5'에서 3' 방향으로 열거되고, 아미노산 서열은 N-말단에서 C-말단으로 열거된다.
본 발명의 다른 목적, 특징 및 장점은 하기 상세한 설명으로부터 자명해질 것이다. 그러나, 본 발명의 정신 및 범주 내의 다양한 변화 및 변형이 본 상세한 설명으로부터 당업자에게 자명해질 수 있는 바, 이에, 상세한 설명 및 구체적인 예는 본 발명의 바람직한 실시양태를 나타내지만, 이는 단지 예로서, 제공되는 것임을 이해하여야 한다.
도면의 간단한 설명
하기 도면은 본 명세서의 일부를 형성하고, 본 개시내용의 특정 측면을 추가로 입증하기 위해 포함된다. 본 개시내용은 본원에 제공된 구체적인 실시양태의 상세한 설명과 함께 조합하여 이들 도면들 중 하나 이상의 것을 참조함으로써 더욱 잘 이해하될 수 있다.
도 1a-1c. 근편집 전략법 및 DMD에서 상위 12개의 엑손을 표적화하는 최적의 가이드 RNA의 확인. (도 1a) 보존적 스플라이스 부위는 SpCas9에 의한 절단을 가능하게 하는 다중의 NAG 및 NGG 서열을 함유한다. 수치는 존재 빈도(%)를 나타낸다. (도 1b) 인간 DMD 엑손 구조. 인트론-엑손 연접부의 형상은 스플라이싱시, 오픈 리딩 프레임을 유지하는 상보성을 나타낸다. 적색 화살촉 표시는 상위 12개의 표적화된 엑손을 나타낸다. 숫자는 엑손의 순서를 나타낸다. (도 1c) 상위 12개의 엑손에 대한 상응하는 가이드 RNA (gRNA), SpCas9, 및 GFP를 발현하는 플라스미드로 형질감염된 인간 293 세포에서의 T7E1 검정법. CRISPR/Cas9-매개 유전자 편집에 의해 유발되는 이종이중체 DNA에 특이적인 T7 엔도뉴클레아제 I (T7E1)을 이용하여 GFP+ 및 GFP- 세포로부터 PCR 생성물을 절단하였다. 적색 화살촉 표시는 T7E1의 절단 밴드를 나타낸다. M은 크기 마커 레인을 표시한다. bp는 마커 밴드의 염기쌍 길이를 나타낸다.
도 2a-2j. 다양한 돌연변이를 포함하는 iPSC -유래 심근세포에서의 근편집에 의해 디스트로핀 mRNA 발현 구제. (도 2a) DMD iPSC 및 3D-EHM 기반 기능성 검정법의 근편집에 관한 개략도. (도 2b) 근편집은 Del DMD iPSC에서 엑손 51 스플라이스 수용자 부위를 표적화한다. DMD 환자에서 결실 (엑손 48 내지 50)은 엑손 51에서 프레임시프트 돌연변이를 생성한다. 적색 박스는 정지 코돈과 함께 프레임 밖의 엑손 51을 나타낸다. DMD iPSC에서의 엑손 51 스플라이스 수용자 파괴로 엑손 47에서 52로 스플라이싱될 수 있고, 디스트로핀 오픈 리딩 프레임이 회복될 수 있다. (도 2c) 가이드 RNA 라이브러리를 이용하여, 엑손 51의 5' 서열을 표적화하는 3개의 가이드 RNA (Ex51-g1, Ex51-g2, 및 Ex51-g3)를 선별하였다. 도 2c는 서열번호: 2481을 개시하는 것이다. (도 2d) 비교정된 DMD (Del), 교정된 DMD iPSC (Del-Cor.), 및 WT로부터 분화된 심근세포의 RT-PCR. 엑손 51의 스키핑을 통해 엑손 47에서 52로 스플라이싱될 수 있고 (하단 밴드), DMD 오픈 리딩 프레임이 회복될 수 있다. (도 2e) 슈도-엑손 47A (pEx)의 근편집 전략법. DMD 엑손은 청색 박스로 제시되어 있다. 정지 코돈과 함께 슈도-엑손 47A (적색)는 정지 사인으로 마킹되어 있다. 검은색 박스는 근편집-매개 삽입/결실(indel)을 나타낸다. (도 2f) pEx의 슈도-엑손 47A에 대한 가이드 RNA의 서열. DMD 엑손은 청색 박스로 제시되어 있고, 슈도-엑손은 적색 박스로 제시되어 있다 (47A). sgRNA, 단일-가이드 RNA. 도 2f는 출현 순서대로 각각 서열번호: 2482-2484를 개시한다. (도 2g) WT, 비교정된 DMD (pEx), 및 가이드 RNA In47A-g1 및 In47A-g2에 의해 교정된 DMD iPSC (pEx-Cor.)로부터 분화된 인간 심근세포의 RT-PCR. 슈도-엑손 47A의 스키핑을 통해 엑손 47에서 48로 스플라이싱될 수 있고 (하단 밴드), DMD 오픈 리딩 프레임이 회복될 수 있다. (도 2h) 엑손 55 내지 59의 중복 (Dup)에 대한 근편집 전략법. DMD 엑손은 청색 박스로 제시되어 있다. 중복된 엑손은 적색 박스로 제시되어 있다. 검은색 박스는 근편집-매개 삽입/결실(indel)을 나타낸다. (도 2i) Dup의 인트론 54에 대한 가이드 RNA (In54-g1, In54-g2, 및 In54-g3)의 서열. 도 2i는 출현 순서대로 각각 서열번호: 2485-2487을 개시한다. (도 2j) WT, 비교정된 DMD (Dup), 및 교정된 DMD iPSC (Dup-Cor.)로부터 분화된 인간 심근세포의 RT-PCR. 중복된 엑손 55 내지 59의 스키핑을 통해 엑손 54에서 55로 스플라이싱될 수 있고, DMD 오픈 리딩 프레임이 회복될 수 있다. 명시된 프라이머 세트 프라이머 (F 및 R) (표 4)를 이용하여 RNA의 RT-PCR을 수행하였다.
도 3a-3f. 면역세포화학법 및 웨스턴 블롯 분석은 근편집에 의해 구제된 디 스트로핀 단백질 발현을 보여준다. (도 3a 내지 3c) 디스트로핀 발현 (녹색)의 면역세포화학법은 디스트로핀 발현이 결여된 DMD iPSC 심근세포를 보여주는 것이다. 성공적인 근편집 후, 교정된 DMD iPSC 심근세포는 디스트로핀을 발현한다. 면역형광 (적색)은 심장 마커 트로포닌-I을 검출한다. 핵은 훽스트(Hoechst) 염료 (청색)에 의해 표지화된다. (도 3d 내지 3f) WT (100 및d 50%), 비교정된 (Del, pEx, 및 Dup) 및 교정된 DMD (Del-Cor#27, pEx-Cor#19, 및 Dup-Cor#6.) iCM의 웨스턴 블롯 분석. 적색 화살촉 표시 (250 kD 초과)는 디스트로핀의 면역반응성 밴드를 나타내는 것이다. 청색 화살촉 표시 (150 kD 초과)는 MyHC 로딩 대조군의 면역반응성 밴드를 나타내는 것이다. kD는 단백질을 분자량을 나타내는 것이다. 스케일 바, 100 mm.
도 4a-4f. 구제된 DMD 심근세포 -유래 EHM은 증강된 FOC (수축 장력)를 보였다. (도 4a) EHM 제조, 배양, 및 수축성 기능 분석을 위한 실험 셋업. (도 4b 내지 4d) DMD EHM에서의 수축성 기능 장애는 근편집에 의해 구제될 수 있다. 세포외 칼슘 농도 증가에 따른 반응으로 각 개별 EHM의 근육 함량으로 정규화된 FOC; n = 8/8/6/4/6/6/4/4; 이원분산 분석 (ANOVA) 및 터키 다중 비교 검정(Tukey's multiple comparison test)에 의하면, *P < 0.05. 명시된 DMD 세포주를 이용한 평행 실험으로부터 WT EHM 데이터를 풀링하고, 도 4 (b 내지 d)에 적용시킨다. (도 4e) WT로 정규화된 최대 심근세포 FOC. n = 8/8/6/4/6/6/4/4; 일원분산 분석 및 터키 다중 비교 검정에 의하면, *P < 0.05. (도 4f) 교정된 심근세포 적정 결과, EHM에서 표현형을 부분적으로 구제하기 위해서는 심근세포 중 30%가 수복되어야 하고, 표현형을 완전히 구제 (100% Del-Cor.)하기 위해서는 심근세포 중 50%가 수복되어야 하는 것으로 밝혀졌다. 도 4에 제시된 바와 같이, WT, Del, 및 100% Del-Cor.은 풀링된 데이터이다.
도 5a- 5b. CRISPR / Cas9에 의한 DMD 상위 12개의 엑손의 유전자 편집. (도 5a) 상응하는 가이드 RNA를 이용하여 SpCas9에 의해 편집된 GPF+ 인간 293 세포로부터의 DMD 상위 12개의 엑손 (51, 45, 53, 44, 46, 52, 50, 43, 6, 7, 8 및 55)의 DNA 서열 (표 5). 각 샘플의 게놈 DNA로부터의 PCR 생성물을 pCRII-TOPO 벡터로 서브클로닝하고, 개별 클론을 취하여 서열분석하였다. 비편집된 야생형 (WT) 서열은 상단에 있고, 대표적인 편집된 서열은 하단에 있다. 결실된 서열은 검은색 대시 표시로 대체되어 있다. 적색 소문자 (ag)는 스플라이스 수용자 부위 (SA, 인트론의 3' 말단)를 나타낸다. 청색 소문자 (gt)는 스플라이스 공여자 부위 (SD, 인트론의 5' 말단)를 나타낸다. 도 5a는 모두 각각 출현 순서대로 좌측 칼럼에서 서열번호: 2488-2526을 개시하고, 우측 칼럼에서는 서열번호: 2427-2546을 개시한다. (도 5b) 편집된 293 세포로부터의 RNA의 RT-PCR은 표적화된 DMD Dp140 이소폼 엑손 (51, 53, 46, 52, 50 및 55)의 결실을 나타낸다. 검은샌 화살표는 엑손 결실을 포함하는 RT-PCR 생성물을 나타낸다. M은 크기 마커 레인을 표시한다. bp는 마커 밴드의 길이를 나타낸다. 엑손 결실 밴드의 RT-PCR 생성물의 서열은 2개의 측면에서 위치하는 서열을 함유하였지만, 표적화된 엑손을 스키핑하였다. 예를 들어, ΔEx51 밴드의 RT-PCR 생성물의 서열을 통해, 엑손 51을 배제하고, 엑손 50이 엑손 52로 직접 스플라이싱되었다는 것이 확인되었다. 도 5b는 서열번호: 2547로서, "GAGCCTGCAACA", 서열번호: 2548로서, "ATCGAACAGTTG", 서열번호: 2549로서 "AAAGAGTTACTG", 서열번호: 2550로서, "CAGAAGTTGAAA", 서열번호: 2551로서 "GTGAAGCTCCTA" 및 서열번호: 2552로서 "TAAAAGGACCTC"를 개시한다.
도 6a-6d. DMD iPSC 및 iPSC -유래 심근세포에서 큰 결실돌연변이 ( Del . Ex47-50)의 교정. (도 6a) SpCas9, gRNA (Ex51-g1, g2 및 g3), 및 GFP를 발현하는 플라스미드로 형질감염된 인간 293 세포를 사용하여 수행된 T7E1 검정법은 DMD 엑손 51에서의 게놈 절단을 보여준다. 적색 화살촉 표시는 절단 생성물을 가리킨다. M, 마커; bp, 염기쌍. (도 6b) SpCas9 및 가이드 RNA Ex51 g3에 의해 편집된 GPF+ DMD Del iPSC로부터의 DMD 엑손 51의 DNA 서열s. 근편집된 DMD iPSC의 혼합물의 게놈 DNA로부터의 PCR 생성물을 pCRII-TOPO 벡터로 서브클로닝하고, 상기 기술된 바와 같이 서열분석하였다. 비교정된 엑손 51 서열은 상단에 있고, 대표적인 편집된 서열은 하단에 있다. 결실된 서열은 검은색 대시 표시로 대체되어 있다. 적색 소문자 (ag)는 스플라이스 수용자 부위를 나타낸다. 결실된 뉴클레오티드의 번호는 (-)로 표시되어 있다. 도 6b는 출현 순서대로 각각 서열번호: 2553-2561을 개시한다. (도 6c) 도 2d로부터의 하단의 RT-PCR 밴드 (Del-Cor. 레인)의 서열을 통해, DMD ORF를 리프레이밍한 엑손 51의 스키핑이 확인된다 (엑손 47에서 52로의 디스트로핀 전사체). 도 6c는 서열번호: 2562를 개시한다. (도 6d) 면역세포화학법은 WT 및 비교정된 심근세포 (Del)와 비교하여, 가이드 RNA Ex51-g3을 이용한 SpCas9-매개 엑손 스키핑 이후의, iPSC-유래 심근세포 혼합물 (Del-Cor.) 및 단일 콜로니 (Del-Cor-Sc)에서의 디스트로핀 발현을 보여준다. 녹색, 디스트로핀 염색; 적색, 트로포닌 I 염색; 청색, 핵 염색. 스케일 바 = 100 ㎛.
도 7a- 7d. DMD iPSC 및 iPSC -유래 심근세포에서의 슈도 -엑손 돌연변이 (pEx47A)의 교정. (도 7a) SpCas9, gRNA (pEx47A-g1 및 g2), 및 GFP를 발현하는 벡터로 뉴클레오펙션된 DMD pEx47A iPSC를 사용하여 수행된 T7E1 검정법은 DMD 슈도-엑손 47A에서의 게놈 절단을 보여준다. 적색 화살촉 표시는 절단 생성물을 가리킨다. M, 마커; bp, 염기쌍. (도 7b) SpCas9 및 가이드 RNA pEx47A-g1 및 g2에 의해 편집된 GPF+ DMD Del iPSC로부터의 DMD 슈도-엑손 47A의 DNA 서열. 근편집된 DMD iPSC의 혼합물의 게놈 DNA로부터의 PCR 생성물을 상기 기술된 바와 같이 서브클로닝하고, 서열분석하였다. 비교정된 슈도-엑손 47A 서열은 상단에 있고, 대표적인 편집된 서열은 하단에 있다. 결실된 서열은 검은색 대시 표시로 대체되어 있다. 적색 소문자 (g)는 잠재적 스플라이스 수용자 부위 중의 점 돌연변이를 나타낸다. 결실된 뉴클레오티드의 번호는 (-)로 표시되어 있다. 도 7b는 출현 순서대로 각각 서열번호: 2563-2567을 개시한다. (도 7c) 도 2g로부터의 하단의 RT-PCR 밴드 (pEx 및 pEx-Cor. 레인)의 서열을 통해, DMD ORF를 리프레이밍한 슈도-엑손 47A의 스키핑이 확인된다 (엑손 47에서 48로의 디스트로핀 전사체). 도 7c는 출현 순서대로 각각 서열번호: 2568-2569를 개시한다. (도 7d) 면역세포화학법은 WT 및 비교정된 심근세포 (pEx)와 비교하여, 가이드 RNA pEx47A-g2를 이용한 SpCas9-매개 엑손 스키핑 이후의, iPSC-유래 심근세포 혼합물 (pEx-Cor.) 및 단일 콜로니 (pEx-Cor-Sc)에서의 디스트로핀 발현을 보여준다. 녹색, 디스트로핀 염색; 적색, 트로포닌 I 염색; 청색, 핵 염색. 스케일 바 = 100 ㎛.
도 8a-8e. DMD iPSC 및 iPSC -유래 심근세포에서의 큰 중복 돌연변이 ( Dup . Ex55-59)의 교정. (도 8a) 상기 삽입 부위 (In59-In54 연접부)는 인트론 59를 표적화하는 정방향 프라이머 (F2) 및 인트론 54를 표적화하는 역방향 프라이머 (F1)를 사용하여 PCR에 의해 확인되었다 (도 2h 및 표 4). 중복-특이적 PCR 밴드는 WT 세포에는 존재하지 않았고, Dup 세포에는 존재하였다. (도 8b) SpCas9, gRNA (In54-g1, g2 및 g3), 및 GFP를 발현하는 벡터와 함께 293 세포를 사용하여 수행된 T7E1 검정법은 DMD 인트론 54에서의 게놈 절단을 보여준다. 적색 화살촉 표시는 절단 생성물을 가리킨다. M, 마커; bp, 염기쌍. (도 8c) 엑손 53 및 엑손 55의 중복 경계 측면에 위치하는 프라이머 (Ex53F, 엑손 53 및 Ex59R에서 정방향 프라이머, 엑손 59에서 역방향 프라이머)를 이용하여 RT-PCR에 의해 중복된 엑손을 갖는 mRNA를 반정량화하였다. 유사하게, 엑손 59 및 엑손 60의 중복 경계 측면에 위치하는 프라이머 (Ex59F, 엑손 59 및 Ex60R에서 정방향 프라이머, 엑손 60에서 역방향 프라이머)를 이용하여 RT-PCR에 의해 중복된 엑손을 반정량화하였다. 중복-특이적 RT-PCR 상단 밴드 (적색 화살촉 표시)는 WT 세포에는 존재하지 않았고, Dup-Cor. 세포.에서는 급격히 감소되었다. (도 8d) 3개의 대표적인 교정된 단일 콜로니 (Dup-Cor-SC #4, 6 및 26) 및 비교정된 대조군 (Dup)의 PCR 결과. 콜로니 4, 6, 및 26에서의 중복-특이적 PCR 밴드 (F2-R1) 부재를 통해 중복된 DNA 영역의 결실을 확인할 수 있었다. M은 크기 마커 레인을 나타낸다. bp는 마커 밴드의 길이는 나타낸다. (도 8e) 면역세포화학법은 WT 및 비교정된 심근세포 (Dup)와 비교하여, 가이드 RNA In54-g1을 이용한 SpCas9-매개 엑손 스키핑 이후의, iPSC-유래 심근세포 혼합물 (Dup-Cor.) 및 단일 콜로니 (Dup-Cor-SC #6)에서의 디스트로핀 발현을 보여준다. 녹색, 디스트로핀 염색; 적색, 트로포닌 I 염색; 청색, 핵 염색. 스케일 바 = 100 ㎛.
상세한 설명
DMD는 인간에서 확인된 4,000개 초과의 독립 돌연변이를 가진 신규한 돌연변이 증후군이다 (dmd.nl의 월드 와이드 웹). 환자 돌연변이 대다수는 핫스팟에 군집하는 결실을 포함하는 바, 특정의 엑손을 스키핑하기 위한 치료적 접근법이 다수의 환자 군에 적용된다. 엑손 스키핑 접근법의 근거는 DMD 환자와 베커 근 이영양증(Becker muscular dystrophy: BMD) 환자 사이의 유전적 차이에 기초한다. DMD 환자에서, 디스트로핀 mRNA의 리딩 프레임은 붕괴되어 미성숙하게 말단절단된, 비-기능성 디스트로핀 단백질을 생성한다. BMD 환자는 리딩 프레임을 유지하는 DMD 유전자내 돌연변이를 가짐으로써 내부적으로 결실되지만, 부분적으로 기능성인 디스트로핀의 생산을 허용함으로써 DMD 환자와 비교하여 훨씬 더 온화한 질환 증상을 야기한다.
뒤센 근 이영양증 (DMD)은 남성 5,000명 중 ~1명에서 발병되며, 이는 X-연관 디스트로핀 유전자 (DMD) 중의 돌연변이에 의해 유발된다. 돌연변이는 큰 결실, 거대 중복, 점 돌연변이, 및 다른 작은 돌연변이를 포함한다. 막대 형상의 디스트로핀 단백질은 근육 세포의 세포외 매트릭스 및 세포골격을 연결하고, 혈장의 무결성을 유지한다. 그의 부재시, 근육 세포는 퇴행한다. 비록 DMD가 다수의 중증 증상을 유발하지만, 확장성 심근증(dilated cardiomyopathy)이 DMD 환자 사망의 주 원인이다.
CRISPR (군집성의 규칙적인 간격을 갖는 짧은 회문구조 반복부)/Cas9 (CRISPR-연관 단백질 9)-매개 유전자 편집이 유전적 장애의 교정을 위한 유망한 도구로서 부상하고 있다. 간략하면, 조작된 RNA-가이드된 뉴클레아제, 예컨대, Cas9 또는 Cpf1은 짧은 프로토스페이서 인접한 모티프 (PAM) 서열에 인접한 표적화된 게놈 유전자좌에서 이중 가닥 파단 (DSb)을 생성한다. DSB를 수복시키는 주요 경로로 3가지가 존재한다: (i) 비상동성 말단 연결 (NHEJ)은 두 DNA 말단을 직접 라이게이션시켜 부정확한 삽입/결실(indel) 돌연변이를 유도한다. (ii) 상동성 유도 수복 (HDR)은 수복 주형으로서 자매 염색분체 또는 외인성 DNA를 사용하여 표적 부위에서 정확한 변형을 생성한다. (iii) 미세상동성-매개 말단 연결 (MMEJ)은 원래의 DSB 측면에 위치하는 뉴클레오티드 상동성의 짧은 서열 (5 내지 25개의 염기쌍)을 이용하여 파단 말단을 라이게이션시키고, 미세상동성 사이의 영역을 결실시킨다. 비록 NHEJ가 대부분의 세포 유형에서 삽입/결실(indel) 돌연변이를 효과적으로 생성할 수 있지만, HDR- 또는 MMEJ-매개 편집은 일반적으로 증식 세포로 한정되는 것으로 간주된다.
디스트로핀의 내부 프레임내 결실은 비교적 경미한 형태의 근 이영양증인 베커 근 이영양증 (BMD)과 연관이 있다. DMD 대비 BMD의 약화된 임상적 중증도에 영감을 받아, 엑손 스키핑은 DMD 유전자의 스플라이싱 패턴을 조정함으로써 디스트로핀 오픈 리딩 프레임을 파괴시키는 돌연변이를 우회하는 치료 전략법으로서 발전하고 있다. 최근 여러 연구에서 CRISPR/Cas9-매개 유전자 편집을 사용하여 인간 세포 및 마우스에서의 다양한 유형의 DMD 돌연변이를 교정하였다. 일부는 돌연변이 교정을 위해 가이드 RNA 쌍을 이용하였는데, 이 경우, DNA의 절단과 큰 개재 게놈 서열 (23 내지 725 kb)의 절제가 동시에 이루어져야 한다. 우발적으로, 가장 최초의, 및 가장 널리 사용되는 형태의 Cas9인 스트렙토코쿠스 피오게네스(Streptococcus pyogenes) Cas9 (SpCas9)에 대한 PAM 서열은 범용 스플라이스 수용자 서열 (AG) 및 대부분의 공여자 서열 (GG)에 상응하는 NAG 또는 NGG를 함유한다. 따라서, 원칙적으로, Cas9의 스플라이스 연접부로의 유도, 및 삽입/결실(indel)에 의한 이들 공통 서열의 제거를 통해 엑손 스키핑을 효율적으로 수행할 수 있다. 추가로, 스플라이스 부위를 파괴하는 DNA의 단 하나의 절단이 전체 엑손의 스키핑을 가능하게 할 수 있다.
수천 개의 개별 DMD 돌연변이가 인간에서 확인되었다는 점을 고려해 볼 때, 분명한 질문은 그 수많은 돌연변이가 어떻게 CRISPR/Cas9-매개 유전자 편집에 의해 교정될 수 있는지에 관한 것이다. 인간 DMD 돌연변이는 유전자의 특정 "핫스팟" 부위 (엑손 45 내지 55 및 엑손 2 내지 10)에 군집되어 있고, ("상위 12개의 엑손"으로 명명되는) 핫스팟 내의 또는 그 인근의 12개의 표적화된 엑손의 스키핑 1 또는 2가 원칙적으로는 DMD 환자 다수 (~60%)의 디스트로핀 기능을 구제할 수 있다. 여기서, CRISPR/Cas9는 DMD 돌연변이 앞의 보존적 스플라이스 수용자 또는 공여자 부위를 파괴시키거나, 또는 돌연변이체 또는 프레임 밖의 엑손을 우회함으로써 주변 엑손 사이의 스플라이싱이 돌연변이가 없는 프레임내 디스트로핀 단백질을 재생성할 수 있도록 하기 위해 단일-가이드 RNA와 함께 사용된다. 상기 접근법은 인근의 돌연변이 핫스팟 내의 가장 보편적으로 돌연변이화된 엑손 또는 프레임 밖의 엑손을 잠재적으로 스키핑할 수 있게 하는 DMD 12 엑손의 스키핑을 유도할 수 있는 최적의 가이드 RNA에 대해 스크리닝함으로써 최초로 시험되었다. 상기 접근법의 예로서, 엑손 결실 및 슈도-엑손 점 돌연변이를 보유하는 유도 만능성 줄기 세포 (iPSc) 유래 심근세포에서 디스트로핀 발현 회복이 입증되었다. 마지막으로, 인간 iPSC 유래 3차원의 (3D) 조작된 심장 근육 (EHM)을 사용하여 DMD와 연관된 심수축성 이상을 극복하는 유전자 편집의 효율에 대해 시험하였다. DMD 환자의 확장성 심근증 (DCM)의 임상적 표현형을 재현하는 DMD EHM에서 수축성 기능 장애가 관찰되었고, 수축성 기능은 교정된 DMD EHM에서 효과적으로 회복되었다. 따라서, 유전자 편집이 유전적 원인을 제거하고, DMD와 연관된 근육 및 심장 이상을 교정할 수 있는 강력한 수단임을 나타낸다.
본 개시내용의 상기 측면 및 다른 측면을 하기에서 추가로 상세하게 설명한다.
CRISPR 시스템
CRISPR (군집성의 규칙적인 간격을 갖는 짧은 회문구조 반복부)은 염기 서열의 짧은 반복부를 함유하는 DNA 유전자좌이다. 각 반복부 다음으로, 바이러스에 대한 이전의 노출로부터의 "스페이서 DNA"의 짧은 세그먼트가 이어진다. CRISPR은 서열분석된 진정세균 게놈의 대략 40% 및 서열분석된 고세균의 90%에서 발견된다. CRISPR은 대개 CRISPR과 관련된 단백질을 코딩하는 Cas 유전자와 연관되어 있다. CRISPR/Cas 시스템은 예컨대, 플라스미드 및 파지와 같은 외부 유전적 요소에 대한 내성을 부여하는 원핵성 면역계이며, 후천성 면역의 한 형태를 제공한다. CRISPR 스페이서는 진핵성 유기체 내에서 RNAi와 같은 이러한 외인성 유전적 요소를 인식하여 침묵화시킨다.
CRISPR 반복부 크기는 24 내지 48개의 염기쌍 범위이다. 이는 일반적으로 일부 2분 대칭을 나타내며, 헤어핀과 같은 2차 구조의 형성을 암시하지만, 실제로는 회문구조는 아니다. 반복부는 유사한 길이의 스페이서에 의해 이격되어 있다. 일부 스페이서는 원핵성 게놈 (자가-표적화 스페이서)와 일치하지만, 일부 CRISPR 스페이서 서열은 플라스미드 및 파지로부터의 서열과 정확하게 매칭된다. 새 스페이서는 파지 감염에 대한 반응으로 신속하게 첨가될 수 있다.
가이드 RNA ( gRNA). RNA 가이드된 단백질로서, Cas9는 DNA 표적의 인식을 지시하기 위해 짧은 RNA를 필요로 한다. Cas9는 우선적으로 PAM 서열 NGG를 함유하는 DNA 서열에서 정보를 얻지만, 이는 여기에 프로토스페이서 표적 없이 결합할 수 있다. 그러나, Cas9-gRNA 복합체는 gRNA에 매우 유사하게 매칭되어 이중 가닥 파닥을 형성하는 것을 필요로 한다. 박테리아에서 CRISPR 서열은 다중 RNA로 발현된 후, 이어서, 프로세싱되어 RNA에 대한 가이드 가닥을 생성한다. 진핵성 시스템에는 CRISPR RNA를 프로세싱하는 데 필요한 단백질 중 일부가 결여되어 있기 때문에, RNA 폴리머라제 III형 프로모터 U6을 사용하여 발현된 단일 RNA로 표적화하는 Cas9에 대한 RNA의 필수적인 조각을 조합하기 위해 합성 구축물 gRNA를 생성하였다. 합성 gRNA는 최소 길이로 100 bp를 약간 초과하고, PAM 서열 NGG 바로 앞의 20개의 프로토스페이서 뉴클레오티드를 표적화하는 부위를 함유하고; gRNA는 PAM 서열을 함유하지 않는다.
일부 실시양태에서, gRNA는 야생형 디스트로핀 유전자 내의 부위를 표적화한다. 예시적인 야생형 디스트로핀 유전자는 단백질 디스트로핀 (진뱅크 수탁 번호(GenBank Accession No.) AAA53189; 서열번호: 5)을 코딩하는, 인간 X 염색체 상에 위치하는 인간 서열 (진뱅크 수탁 번호 NC_000023.11)을 포함하고, 그의 서열은 하기에 재현되어 있다:
Figure pct00001
일부 실시양태에서, gRNA는 돌연변이체 디스트로핀 유전자 내의 부위를 표적화한다. 일부 실시양태에서, gRNA는 디스트로핀 인트론을 표적화한다. 일부 실시양태에서, gRNA는 디스트로핀 엑손을 표적화한다. 일부 실시양태에서, gRNA는 표 1에 제시된 디스트로핀 이소폼 중 하나 이상의 것에서 발현되고, 그에 존재하는 디스트로핀 엑손 중의 부위를 표적화한다. 실시양태에서, gRNA는 디스트로핀 스플라이스 부위를 표적화한다. 일부 실시양태에서, gRNA는 디스트로핀 유전자 상의 스플라이스 공여자 부위를 표적화한다. 실시양태에서, gRNA는 디스트로핀 유전자 상의 스플라이스 수용자 부위를 표적화한다.
Figure pct00002
Figure pct00003
Figure pct00004
Figure pct00005
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Figure pct00007
실시양태에서, 가이드 RNA는 돌연변이체 DMD 엑손을 표적화한다. 일부 실시양태에서, 돌연변이체 엑손은 엑손 23 또는 51이다. 일부 실시양태에서, 가이드 RNA는 디스트로핀 유전자의 엑손 1, 23, 41, 44, 46, 47, 48, 49, 50, 51, 52, 53, 54, 또는 55 중 적어도 하나를 표적화한다. 실시양태에서, 가이드 RNA는 디스트로핀 유전자의 인트론 44, 45, 50, 51, 52, 53, 54, 또는 55 중 적어도 하나를 표적화한다. 바람직한 실시양태에서, 가이드 RNA는 엑손 51 또는 엑손 23의 스키핑을 유도하도록 디자인된다. 실시양태에서, gRNA는 엑손 51 또는 엑손 23의 스플라이스 수용자 부위로 표적화된다.
본원에 개시된 다양한 조성물 및 방법에 사용하기에 적합한 gRNA 및 게놈 표적 서열은 서열번호: 60-705, 712-862, 및 947-2377로서 제공된다.
일부 실시양태에서, gRNA 또는 gRNA 표적 부위는 표 5-19에 제시된 gRNA 또는 gRNA 표적 부위 중 어느 하나의 서열을 갖는다.
일부 실시양태에서, 본 개시내용의 gRNA는 DMD 유전자에 상응하는 코딩 서열 또는 비-코딩 서열 내의 표적 서열에 상보적이고, 따라서, 표적 서열에 하이브리드화하는 서열을 포함한다. 일부 실시양태에서, Cpf1에 대한 gRNA는 직접 반복부 스캐폴드 서열에 이어서, 가이드 서열의 24개의 뉴클레오티드를 함유하는 단일의 crRNA를 포함한다. 일부 실시양태에서, crRNA의 "가이드" 서열은 표적 서열에 상보적인 gRNA의 서열을 포함한다. 일부 실시양태에서, 본 개시내용의 crRNA는 표적 서열에 상보적이지 않은 gRNA의 서열을 포함한다. 본 개시내용의 "스캐폴드" 서열은 gRNA를 Cpf1 폴리펩티드에 연결한다. 본 개시내용의 "스캐폴드" 서열은 gRNA-Cas9 구축물의 tracrRNA 서열과 등가의 것이 아니다.
일부 실시양태에서, 핵산은 gRNA를 코딩하는 하나 이상의 서열을 포함할 수 있다. 일부 실시양태에서, 핵산은 gRNA를 코딩하는 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 또는 20개의 서열을 포함할 수 있다. 일부 실시양태에서, 모든 서열이 동일한 gRNA를 코딩한다. 일부 실시양태에서, 모든 서열이 상이한 gRNA를 코딩한다. 일부 실시양태에서, 서열 중 적어도 2개가 동일한 gRNA를 코딩하고, 예를 들어, 서열 중 적어도 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 또는 20개가 동일한 gRNA를 코딩한다.
뉴클레아제
Cas 뉴클레아제. CRISPR-연관 (cas) 유전자는 대개 CRISPR 반복부-스페이서 어레이와 연관이 있다. 2013년 현재, 40개 초과의 상이한 Cas 단백질 패밀리가 기술되어 있다. 이들 단백질 패밀리 중에서, Cas1은 상이한 CRISPR/Cas 시스템 중에서 편재하는 것으로 보인다. cas 유전자와 반복부 구조의 특수한 조합을 사용하여 8개의 CRISPR 서브타입 (Ecoli, Ypest, Nmeni, Dvulg, Tneap, Hmari, Apern, 및 Mtube)을 정의하였으며, 이들 중 일부는 반복부-연관 미스테리 단백질 (RAMP)을 코딩하는 추가의 유전자 모듈과 연관이 있다. 1개 초과의 CRISPR 서브타입이 단일 게놈에 존재할 수 있다. CRISPR/Cas 서브타입의 산발적인 분포는 이러한 시스템이 미생물 진화 동안 수평적 유전자 전달에 적용됨을 시사하고 있다.
외인성 DNA는 겉보기상 Cas 유전자에 의해 코딩된 단백질에 의해 작은 요소 (~30개의 염기쌍 길이)로 프로세싱되며, 이는 이후에 어느 정도 리더 서열 인근의 CRISPR 유전자좌로 삽입된다. CRISPR 유전자좌로부터의 RNA는 구성적으로 발현되고, Cas 단백질에 의해, 측면에 위치하는 반복 서열을 가진 개별 외인성 유래 서열 요소로 구성된 작은 RNA로 프로세싱된다. RNA는 다른 Cas 단백질을 가이드하여 RNA 또는 DNA 수준에서 외인성 유전 요소를 침묵화시킨다. 증거는 CRISPR 서브타입 중의 기능적 다양성을 시사한다. Cse (Cas 서브타입 Ecoli) 단백질 (E. 콜라이(E. coli)에서 CasA-E로 명명됨)은 CRISPR RNA 전사체를 해당 캐스케이드가 보유한 스페이스-반복 단위로 프로세싱하는, 기능성 복합체인, 캐스케이드를 형성한다. 다른 원핵생물에서, Cas6는 CRISPR 전사체를 프로세싱한다. 흥미롭게도, E. 콜라이에서 CRISPR-기반 파지 불활성화는 캐스케이드 및 Cas3을 필요로 하지만, Cas1 및 Cas2는 필요로 하지 않는다. 피로코쿠스 푸리오수스(Pyrococcus furiosus) 및 다른 원핵생물에서 발견된 Cmr (Cas RAMP 모듈) 단백질은 상보성 표적 RNA를 인식하여 그를 절단하는 작은 CRISPR RNA와 기능성 복합체를 형성한다. RNA-가이드된 CRISPR 효소는 V형 제한 효소로 분류된다.
Cas9는 이중 나선의 각 가닥에 대해 하나씩 2개의 활성 절단 부위를 가지고, DNA를 절단하기 위한 것으로 특수화된 효소인 뉴클레아제이다. Cas9는 그의 표적 DNA를 국재화할 수 있는 능력은 보존하면서, 상기의 한 부위 또는 두 부위 모두 비활성화될 수 있다. 지네크(Jinek) 등 (문헌 [Jinek et al. (2012)])은 tracrRNA 및 스페이서 RNA를 "단일-가이드 RNA" 분자로 조합하였으며, 이는 Cas9와 혼합되어, 올바른 DNA 표적을 발견하여 절단할 수 있고, 이러한 합성 가이드 RNA는 유전자 편집에 사용된다.
Cas9 단백질은 병원성 및 공생 박테리아에 매우 풍부하다. CRISPR/Cas-매개 유전자 조절은 특히 진핵성 숙주와의 박테리아 상호작용 동안에 내인성 박테리아 유전자의 조절에 기여할 수 있다. 예를 들어, 프란시셀라 노비시다(Francisella novicida)의 Cas 단백질 Cas9는 유일의 작은 CRISPR/Cas-연관 RNA (scaRNA)를 사용하여 F. 노비시다(F. novicida)에 중요한 박테리아 지질단백질을 코딩하는 내인성 전사체를 억제함으로써 숙주 반응을 약화시키고, 병독성을 촉진시킨다. Cas9 mRNA 및 sgRNA의 생식세포계열 (접합체) 내로의 공동주사를 이용하여 돌연변이를 가진 마우스를 생성할 수 있는 것으로 나타났다. Cas9 DNA 서열 전달 또한 고려된다.
CRISPR/Cas 시스템은 3개 부류로 분류된다. 클래스 1은 CRISPR RNA (crRNA)와 함께 수개의 Cas 단백질을 사용하여 기능성 엔도뉴클레아제를 구축한다. 클래스 2 CRISPR 시스템은 crRNA를 지닌 단일 Cas 단백질을 사용한다. Cpf1은 최근 ~1,300개의 아미노산 단백질을 함유하는 클래스 II, 타입 V CRISPR/Cas로 확인되었다. 또한, 미국 특허 공개 2014/0068797 (상기 특허는 그 전문이 본원에서 참조로 포함된다) 또한 참조한다.
일부 실시양태에서, 본 개시내용의 조성물은 스타필로코쿠스 아우레우스(Staphylococcus aureus) (유니프로트 수탁 번호(UniProt Accession No.) J7RUA5)로부터의 Cas9의 작은 버전을 포함한다. Cas9의 작은 버전은 야생형 또는 전장의 Cas9에 비해 이점을 제공한다. 일부 실시양태에서, Cas9는 스트렙토코쿠스 피오게네스 (spCas9)이다.
Cpf1 뉴클레아제. 프레보텔라(Prevotella) 및 프란시셀라(Francisella) 1로부터의 군집성의 규칙적인 간격을 갖는 짧은 회문구조 반복부 또는 CRISPR/Cpf1은 CRISPR/Cas9 시스템과 일부 유사성을 공유하는 DNA-편집 기술이다. Cpf1은 부류 II CRISPR/Cas 시스템의 RNA-가이드된 엔도뉴클레아제이다. 이러한 후천성 면역 계는 프레보텔라 및 프란시셀라 박테리아에서 발견된다. 이는 바이러스로부터의 유전적 손상을 막는다. Cpf1 유전자는 가이드 RNA를 사용하여 바이러스 DNA를 발견하고, 이를 절단하는 엔도뉴클레아제를 코딩하는 CRISPR 유전자좌와 연관이 있다. Cpf1은 Cas9보다 더 작고, 더 간단한 엔도뉴클레아제이며, CRISPR/Cas9 시스템 한계 중 일부를 극복한다.
Cpf1은 많은 박테리아 종에서 출현한다. 게놈 편집을 위한 도구로 개발된 최종의 Cpf1 엔도뉴클레아제는 이를 보유한 것으로 공지된 처음 16개 종 중 하나로부터 입수되었다.
실시양태에서, Cpf1은 하기 기재된 서열을 갖는 악시드아미노코쿠스(Acidaminococcus) (종 BV3L6, 유니프로트 수탁 번호 U2UMQ6; 서열번호: 870)로부터의 Cpf1 효소이다:
Figure pct00008
일부 실시양태에서, Cpf1은 하기 기재된 서열을 갖는 라크노스피라세아에(Lachnospiraceae) (종 ND2006, 유니프로트 수탁 번호 A0A182DWE3; 서열번호: 871)로부터의 Cpf1 효소이다:
Figure pct00009
일부 실시양태에서, Cpf1은 포유동물 세포에서의 발현을 위해 코돈 최적화된다. 일부 실시양태에서, Cpf1은 인간 세포 또는 마우스 세포에서의 발현을 위해 코돈 최적화된다.
Cpf1 유전자좌는 혼합된 알파/베타 도메인, RuvC-I에 이은 나선 영역, RuvC-II 및 아연 핑거-유사 도메인을 함유한다. Cpf1 단백질은 Cas9의 RuvC 도메인과 유사한 RuvC-유사 엔도뉴클레아제 도메인을 갖는다. 추가로, Cpf1은 HNH 엔도뉴클레아제 도메인을 가지지 않고, Cpf1의 N-말단은 Cas9의 알파-나선 인식 로브를 가지지 않는다.
도메인 구조는 Cpf1이 기능적으로 유일하며, 클래스 2, V형 CRISPR 시스템으로 분류됨을 나타낸다. Cpf1 유전자좌는 II형 시스템보다는 I형 및 III형과 더 유사한 Cas1, Cas2 및 Cas4 단백질을 코딩한다. 데이터베이스 검색은 많은 박테리아 종에서 Cpf1-패밀리 단백질의 풍부함을 시사한다.
기능성 Cpf1은 tracrRNA를 필요로 하지 않는 바, 오직 crRNA 만이 요구된다. 이는 Cpf1이 Cas9보다 더 작을 뿐만 아니라, 더 작은 sgRNA 분자 (대략 Cas9와 같이 많은 뉴클레오티드의 대략 1/2)를 가지므로 유전자 편집에 유리하다.
Cpf1-crRNA 복합체는 Cas9에 의해 표적화된 G가 풍부한 PAM과는 대조적으로, 프로토스페이서 인접한 모티프 5'-YTN-3' (여기서, "Y"는 피리미딘이고, "N"은 임의의 뉴클레오베이스이다) 또는 5'-TTN-3'의 확인에 의해 표적 DNA 또는 RNA를 절단한다. PAM의 확인 후, Cpf1은 4 또는 5개의 뉴클레오티드 오버행의 점착성-말단-유사 DNA 이중 가닥 파단을 도입한다.
CRISPR/Cpf1 시스템은 Cpf1 효소 및 이중 나선 상의 올바른 지점에서 복합체를 발견하고, 위치시켜 표적 DNA를 절단하는 가이드 RNA로 이루어져 있다. CRISPR/Cpf1 시스템 활성은 3개의 단계를 갖는다:
적합화, 이 단계 동안 Cas1 및 Cas2 단백질은 DNA의 작은 단편의 CRISPR 어레이로의 적합화를 촉진시킨다;
crRNA의 형성: Cas 단백질을 가이드하기 위해 성숙한 crRNA를 생산하는 프리-cr-RNA의 프로세싱; 및
간섭, 여기서, Cpf1은 crRNA에 결합하여 표적 DNA 서열을 확인하고, 절단하는 이원 복합체를 형성한다.
Cas9 대 Cpf1. Cas9는 DNA를 절단하기 위해 2개의 RNA 분자를 필요로 하지만, Cpf1은 하나의 DNA 분자를 필요로 한다. 단백질은 또한 상이한 위치에서 DNA를 절단하여, 편집 부위를 선택하는 경우 연구자에게 더 많은 옵션을 제공한다. Cas9는 동일한 위치에서 DNA 분자내 두 가닥 모두를 절단하여, '블런트' 말단을 남긴다. Cpf1은 다른 것보다 더 긴 하나의 가닥을 남김으로써, 함께 작업하기 더 쉬운 '점착성' 말단을 생성한다. Cpf1은 Cas9와 비교하여, 절단 부위에서 새로운 서열을 보다 더 삽입할 수 있는 것으로 여겨진다. CRISPR/Cas9 시스템은 유전자를 효율적으로 무능화시키지만, 이는 유전자를 삽입시키거나, 넉-인을 생성하기 위한 도전과제이다. Cpf1에는 tracrRNA이 결여되어 있고, T가 풍부한 PAM을 이용하고, 스태거드(staggered) DNA DSB를 통해 DNA를 절단한다.
요약하면, Cpf1 시스템과 Cas9 시스템 사이의 중요한 차이는 Cpf1이 상이한 PAM을 인식하여, 새로운 표적화 가능성을 가능하게 만들며, Cas9에 의해 생성된 블런트 말단 대신에, 4-5 nt 길이의 점착성 말단을 생성하며, 유전자 삽입의 효율 및 NHEJ 또는 HDR 동안의 특이성을 증진시키고, 표적 DNA를 PAM으로부터 더 멀리, Cas9 절단 부위로부터 더 멀리 절단하여, DNA를 절단하기 위한 새로운 가능성을 가능하게 만든다.
Cas9와 Cpf1의 차이
특징 Cas9 Cpf1
구조 2개의 RNA가 필요 (또는 1개의 융합 전사체 (crRNA+tracrRNA=gRNA)) 1개의 RNA가 필요
절단 기전 블런트 말단 절단 스태거드 말단 절단
절단 부위 인식 부위에 인접한 근위 인식 부위로부터 먼 원위
표적 부위 G가 풍부한 PAM T가 풍부한 PAM
다른 뉴클레아제. 일부 실시양태에서, 뉴클레아제는 Cas9 또는 Cpf1 뉴클레아제이다. Cas9 뉴클레아제 및 Cpf1 뉴클레아제 이외에도, 다른 뉴클레아제가 본 개시내용의 조성물 및 방법에서 사용될 수 있다. 예를 들어, 일부 실시양태에서, 뉴클레아제는 타입 II, 타입 V-A, 타입 V-B, 타입 V-C, 타입 V-U, 타입 VI-B 뉴클레아제이다. 일부 실시양태에서, 뉴클레아제는 Cas9, Cas12a, Cas12b, Cas12c, Tnp-B 유사, Cas13a (C2c2), 또는 Cas13b 뉴클레아제이다. 일부 실시양태에서, 뉴클레아제는 TAL 뉴클레아제, 메가뉴클레아제, 또는 아연-핑거 뉴클레아제이다.
CRISPR -매개 유전자 편집. CRISPR/Cpf1 또는 CRISPR/Cas9 (또는 또 다른 뉴클레아제)를 사용하여 DMD 유전자를 편집하는 데 있어서 제1 단계는 게놈 표적 서열을 확인하는 것이다. 본 개시내용의 gRNA에 대한 게놈 표적은 임의의 대략 24개의 뉴클레오티드 DNA 서열일 수 있으며, 단, 서열은 게놈의 나머지와 비교하여 고유한 것이다. 일부 실시양태에서, 게놈 표적 서열은 인간 디스트로핀 유전자의 엑손 51, 엑손 45, 엑손 44, 엑손 53, 엑손 46, 엑손 52, 엑손 50, 엑손 43, 엑손 6, 엑손 7, 엑손 8, 및/또는 엑손 55 내의 서열에 상응한다. 일부 실시양태에서, 게놈 표적 서열은 인간 디스트로핀 유전자의 엑손 51, 엑손 45, 엑손 44, 엑손 53, 엑손 46, 엑손 52, 엑손 50, 엑손 43, 엑손 6, 엑손 7, 엑손 8, 및/또는 엑손 55의 5' 또는 3' 스플라이스 부위이다. 일부 실시양태에서, 게놈 표적 서열은 인간 디스트로핀 유전자의 엑손 51, 엑손 45, 엑손 44, 엑손 53, 엑손 46, 엑손 52, 엑손 50, 엑손 43, 엑손 6, 엑손 7, 엑손 8, 및/또는 엑손 55의 상류 또는 하류 방향으로 바로 옆의 인트론 내의 서열에 상응한다. 예시적인 게놈 표적 서열은 표 2, 6, 8, 10, 12, 14 및 19에서 살펴볼 수 있다.
DMD 유전자를 편집하는 데 있어 다음 단계는 표적화되는 유전자 영역내의 프로토스페이서 인접한 모티프 (PAM) 서열을 확인하는 것이다. 표적 서열은 PAM의 상류 방향으로 바로 옆에 위치하여야 한다. 일단 모든 가능한 PAM 서열 및 추정 표적 부위가 확인되고 나면, 다음 단계는 어느 부위가 가장 효율적인 온-타겟 절단을 생성할 가능성이 있는지 그 부위를 선택하는 것이다.　gRNA 표적화 서열은 표적 서열과 매칭되어야 하고, gRNA 표적화 서열은 게놈 내의 추가 부위와 매칭되지 않아야 한다. 바람직한 실시양태에서, gRNA 표적화 서열은 게놈내 어느 곳에서도 상동성을 보이지 않으며, 표적에 대해서는 완벽한 상동성을 갖는다. 일부 실시양태에서, 주어진 gRNA 표적화 서열은 부분 상동성이 존재하는 게놈 전체에 걸쳐 추가 부위를 가질 것이다. 이들 부위는 "오프-타겟"으로 명명되고, gRNA를 디자인하는 경우 고려되어야 한다. 일반적으로, 오프-타겟 부위는 PAM 서열 근처에서 미스매칭되는 경우에는 효율적으로 절단되지 않는 바, 이에, 상동성이 없는 gRNA, 또는 PAM 서열 근처에서 미스매칭이 이루어지는 gRNA는 최고의 특이성을 가질 것이다. "오프-타겟 활성" 이외에도, 원하한 표적 서열의 절단을 최대화하는 인자 ("온-타겟 활성")이 고려되어야만 한다. 각각 표적 DNA에 대해 100%의 상동성을 갖는, 2개의 gRNA 표적화 서열이 등가의 절단 효율을 생성하지 않을 수 있다는 것은 당업자에게 공지되어 있다. 실제로, 절단 효율은 선택된 표적 서열 내의 특이적인 뉴클레오티드에 의존하여 증가하거나 감소할 수 있다. 각각의 잠재적인 gRNA 표적화 서열의 예측된 온-타겟 및 오프-타겟 활성의 엄밀한 검사는 최고의 gRNA를 디자인하는 데 필요하다. 잠재적인 PAM 및 표적 서열을 위치시키고, 연관된 gRNA를 그의 예측된 온-타겟 및 오프-타겟 활성을 기반으로 하여 등급화할 수 있는 수개의 gRNA 디자인 프로그램이 개발되었다 (예컨대, CRISPRdirect, www.crispr.dbcls.jp에서 이용가능).
다음 단계는 원하는 gRNA를 합성하고, 클로닝하는 것이다. 표적화 올리고는 표준 제한-라이게이션 클로닝을 이용하여 합성하고, 어닐링하고, gRNA 스캐폴드를 함유하는 플라스미드 내로 삽입할 수 있다. 그러나, 정확한 클로닝 전략법은 선택되는 gRNA 벡터에 의존할 것이다. Cpf1에 대한 gRNA는 Cas9에 대한 gRNA보다 특히 더 간단하고, 이는 단지 직접 반복 스캐폴드 서열에 이어서, 가이드 서열의 대략 24개의 뉴클레오티드를 함유하는 단일 crRNA로만 구성된다.
이어서, 각각의 gRNA는 하나 이상의 표적 세포주에서 입증되어야 한다. 예를 들어, Cas9 또는 Cpf1 및 gRNA가 세포로 전달된 후, 게놈 표적 영역은 당업자에게 공지된 방법에 따라, PCR을 사용하여 증폭될 수 있고, 서열분석될 수 있다.
일부 실시양태에서, 유전자 편집은 시험관내 또는 생체외에서 수행될 수 있다. 일부 실시양태에서, 세포는 시험관내 또는 생체외에서 Cas9 또는 Cpf1 및 디스트로핀 스플라이스 부위를 표적화하는 gRNA와 접촉된다. 일부 실시양태에서, 세포는 Cas9 또는 Cpf1 및 가이드 RNA를 코딩하는 하나 이상의 핵산과 접촉된다. 일부 실시양태에서, 하나 이상의 핵산은 예를 들어, 리포펙션 또는 전기천공을 사용하여 세포 내로 도입된다. 유전자 편집은 또한 접합체 내에서 수행될 수 있다. 실시양태에서, 접합체는 Cas9 또는 Cpf1을 코딩하는 하나 이상의 핵산 및 디스트로핀 스플라이스 부위를 표적화하는 gRNA와 함께 주사될 수 있다. 이어서, 접합체는 숙주 내로 주사될 수 있다.
실시양태에서, Cas9 또는 Cpf1은 벡터 상에 제공된다. 실시양태에서, 벡터는 S. 피오게네스(S. pyogenes)로부터 유래된 Cas9 (SpCas9, 서열번호: 872)를 함유한다. 실시양태에서, 벡터는 S. 아우레우스(S. aureus)로부터 유래된 Cas9 (SaCas9, 서열번호: 873)를 함유한다. 실시양태에서, 벡터는 라크노스피라세아에 박테리아로부터 유래된 Cpf1 서열을 함유한다. 예를 들어, 유니프로트 수탁 번호 A0A182DWE3; 서열번호: 871을 참조한다. 실시양태에서, 벡터는 악시드아미노코쿠스 박테리아으로부터 유래된 Cpf1 서열을 함유한다. 예를 들어, 유니프로트 수탁 번호 U2UMQ6; 서열번호: 870을 참조한다. 일부 실시양태에서, Cas9 또는 Cpf1 서열은 인간 세포 또는 마우스 세포에서의 발현을 위해 코돈 최적화된다. 일부 실시양태에서, 벡터는, Cas9 또는 Cpf1-발현 세포가 형광 활성 세포 분류 (FACS)를 사용하여 분류될 수 있도록 하는, 형광성 단백질, 예컨대, GFP를 코딩하는 서열을 추가로 함유한다. 일부 실시양태에서, 벡터는 바이러스 벡터, 예컨대, 아데노-연관 바이러스 벡터이다.
실시양태에서, gRNA는 벡터 상에 제공된다. 일부 실시양태에서, 벡터는 바이러스 벡터, 예컨대, 아데노-연관 바이러스 벡터이다. 실시양태에서, Cas9 또는 Cpf1 및 가이드 RNA는 동일한 벡터 상에 제공된다. 실시양태에서, Cas9 또는 Cpf1 및 가이드 RNA는 상이한 벡터 상에 제공된다.
일부 실시양태에서, 세포는 단일-가닥 DNA 올리고뉴클레오티드와 추가로 접촉함으로써 상동성 유도 수복을 수행한다. 일부 실시양태에서, 작은 삽입/결실(INDEL)은 디스트로핀의 단백질 리딩 프레임을 회복한다 ("리프레이밍" 전략법)). 리프레이밍 전략법이 사용된 경우, 세포는 단일 gRNA와 접촉할 수 있다. 실시양태에서, 스플라이스 공여자 또는 스플라이스 수용자 부위 는 파괴되고, 그 결과로 엑손 스키핑 및 단백질 리딩 프레임 회복이 이루어진다 ("엑손 스키핑" 전략법). 엑손 스키핑 전략법이 사용되는 경우, 세포는 2개 이상의 gRNA와 접촉할 수 있다.
시험관내 또는 생체외 Cas9 또는 Cpf1-매개 DNA 절단의 효율은 당업자에게 공지된 기술, 예컨대, T7 E1 검정법을 사용하여 사정될 수 있다. DMD 발현의 회복은 당업자에게 공지된 기술, 예컨대, RT-PCR, 웨스턴 블롯팅, 및 면역세포화학법을 사용하여 확인할 수 있다.
일부 실시양태에서, 시험관내 또는 생체외 유전자 편집은 근육 또는 성상세포 세포에서 수행된다. 일부 실시양태에서, 유전자 편집은 iPSC iCM 세포에서 수행된다. 실시양태에서, iPSC 세포는 유전자 편집 이후에 분화된다. 예를 들어, iPSC 세포는 편집 이후에 근육 세포 또는 성상세포 세포로 분화될 수 있다. 실시양태에서, iPSC 세포는 심장 근육 세포, 골격근 세포, 또는 평활근 세포로 분화된다. 실시양태에서, iPSC 세포는 심근세포로 분화된다. iPSC 세포는 당업자에게 공지된 방법에 따라 분화되도록 유도될 수 있다.
일부 실시양태에서, 세포를 Cas9 또는 the Cpf1 및 gRNA와 접촉시키는 것이 디스트로핀 발현을 회복시킨다. 실시양태에서, 시험관내 또는 생체외에서 편집된 세포, 또는 그로부터 유래된 세포는 야생형 세포와 비교가능한 디스트로핀 단백질의 수준을 나타낸다. 실시양태에서, 편집된 세포, 또는 그로부터 유래된 세포는 야생형 디스트로핀 발현 수준의 50%, 60%, 70%, 80%, 90%, 95%, 또는 그 사이의 임의의 비율인 수준으로 디스트로핀을 발현한다. 실시양태에서, 시험관내 또는 생체외에서 편집된 세포, 또는 그로부터 유래된 세포는 야생형 세포와 비교가능한 미토콘드리아 개수를 갖는다. 실시양태에서, 편집된 세포, 또는 그로부터 유래된 세포는 야생형 세포만큼 많은 다수의 미토콘드리아를 50%, 60%, 70%, 80%, 90%, 95% 또는 그 사이의 임의의 비율로 갖는다. 실시양태에서, 편집된 세포, 또는 그로부터 유래된 세포는 기준선에서 비편집된 세포와 비교하여 산소 소비율 (OCR) 증가를 나타낸다.
핵산 발현 벡터. 상기에서 논의된 바와 같이, 특정 실시양태에서, 발현 카세트는 후속 정제 및 세포/대상체로의 전달을 위해, 또는 유전자-기반 전달 접근법에서 직접 사용하기 위해 전사 인자 생성물을 발현하는 데 사용된다. 본원에서는 Cas9 또는 Cpf1을 코딩하는 하나 이상의 핵산 및 디스트로핀 스플라이스 부위를 표적화하는 적어도 하나의 DMD 가이드 RNA를 코딩하는 하나 이상의 핵산을 함유하는 발현 벡터를 제공한다. 일부 실시양태에서, Cas9 또는 Cpf1을 코딩하는 핵산, 및 적어도 하나의 가이드 RNA를 코딩하는 핵산은 동일한 벡터 상에 제공된다. 추가의 실시양태에서, Cas9 또는 Cpf1을 코딩하는 핵산, 및 적어도 하나의 가이드 RNA를 코딩하는 핵산은 별개의 벡터 상에 제공된다.
발현은 적절한 신호가 벡터 내에 제공되는 것을 필요로 하며, 세포 내에서 관심 유전자의 발현을 구동시키는 바이러스 및 포유동물 공급원, 둘 모두로부터의 인핸서/프로모터와 같은 다양한 조절 요소를 포함한다. 메신저 RNA 안전성 및 숙주 세포내에서의 번역성을 최적화하도록 디자인된 요소 또한 정의된다. 생성물을 발현하는 영구적이고, 안정적인 세포 클론을 확립하기 위한 다수의 우성 약물 선별 마커를 사용하기 위한 조건은, 약물 선택 마커의 발현이 폴리펩티드의 발현과 연관이 있는 요소인 바, 이 또한 제공된다.
본 출원 전체에 걸쳐, "발현 카세트"라는 용어는 서열을 코딩하는 핵산 중 일부 또는 그 모두가 전사되고 번역될 수 있는, 즉, 프로모터의 제어하에 있는, 유전자 생성물을 코딩하는 핵산을 함유하는 임의 유형의 유전자 구축물을 포함하는 것을 의미한다. "프로모터"는 세포의 합성 기구 또는 도입된 합성 기구에 의해 인식되는, 유전자의 특이적인 전사를 개시하는 데 필요한 DNA 서열을 지칭한다. "전사 제어하에"라는 어구는 프로모터가 핵산과 관련하여 RNA 폴리머라제 개시 및 유전자의 발현을 제어하는 데 올바른 위치 및 배향으로 있다는 것을 의미한다. "발현 벡터"는 복제될 수 있는 유전 구축물 내에 포함됨으로써 하나 이상의 복제 기점, 전사 종결 신호, 폴리-A 영역, 선별가능한 마커, 및 다목적 클로닝 부위를 포함하는 발현 카세트를 포함하는 것을 의미한다.
조절 요소. 프로모터라는 용어는 RNA 폴리머라제 II에 대한 개시 부위 주변에 군집되는 전사 제어 모듈 군을 지칭하기 위해 본원에서 사용될 것이다. 프로모터가 구조화되는 방법에 대한 생각 대부분은 HSV 티미딘 키나제 (tk) 및 SV40 조기 전사 단위에 대한 것을 비롯한, 수개의 바이러스 프로모터의 분석으로부터 도출된 것이다. 더욱 최근의 연구에 의해 강화된 이들 연구 결과, 프로모터가, 각각은 대략 7-20 bp의 DNA로 이루어지고, 전사 활성인자 또는 억제인자 단백질에 대한 하나 이상의 인식 부위를 함유하는 것인 별개의 기능성 모듈로 구성되는 것으로 나타났다.
각 프로모터내의 적어도 하나의 모듈은 RNA 합성을 위한 출발 부위를 위치시키는 작용을 한다. 이의 가장 잘 알려진 예로는 TATA 박스이지만, TATA 박스가 없는 일부 프로모터, 예컨대, 포유동물 말단 데옥시뉴클레오티딜 트랜스퍼라제 유전자에 대한 프로모터 및 SV40 후기 유전자에 대한 프로모터에서, 출발 부위 자체에 놓여있는 별개의 요소는 개시의 위치를 고정시키는 것을 돕는다.
RNA 폴리머라제 및 Pol III 프로모터. 진핵생물에서, RNA 폴리머라제 III (이는 또한 Pol III으로도 명명됨)은 DNA를 전사하여 리보솜 5S rRNA, tRNA 및 다른 작은 RNA를 합성한다. RNA Pol III에 의해 전사된 유전자는 그의 발현이 모든 세포 유형 및 대부분의 환경 조건에서 요구되는 "하우스키핑" 유전자의 카테고리에 포함된다. 따라서, Pol III 전사의 조절은 주로 세포 성장 및 세포 주기의 조절과 관련이 있는 바, RNA 폴리머라제 II보다 더 적은 조절 단백질을 필요로 한다. 그러나, 스트레스 조건하에서, 단백질 Maf1은 Pol III 활성을 억제한다.
(임의의 폴리머라제에 의한) 전사 프로세스에는 3개의 주요 단계가 존재한다: (i) 유전자의 프로모터에서 RNA 폴리머라제 복합체의 구축을 필요로 하는 개시; (ii) RNA 전사체의 합성인 신장; 및 (iii) RNA 전사 종료 및 RNA 폴리머라제 복합체의 분해인 종결.
RNA Pol III의 제어하의 프로모터는 리보솜 5S rRNA, tRNA 및 더 소수의 작은 RNA, 예컨대, U6 스플라이스좀 RNA, RNase P 및 RNase MRP RNA, 7SL RNA (시그날 인식 입자의 RNA 성분), Vault RNA, Y RNA, SINE (짧은 산재된 반복 요소), 7SK RNA, 2개의 마이크로RNA, 수개의 작은 핵소체 RNA 및 수개의 소수의 조절 안티센스 RNA에 대한 것을 포함한다.
추가의 프로모터 및 요소
일부 실시양태에서, 본 개시내용의 Cas9 또는 Cpf1 구축물은 근육-세포 특이적 프로모터에 의해 발현된다. 상기 근육-세포 특이적 프로모터는 구성적으로 활성일 수 있거나, 또는 유도성 프로모터일 수 있다.
추가의 프로모터 요소는 전사 개시의 빈도를 조절한다. 전형적으로, 다수의 프로모터가 최근에 출발 부위 하류의 기능성 요소 또한 함유하는 것으로 밝혀졌지만, 이는 출발 부위로부터 상류쪽 30-110 bp 영역에 위치한다. 프로모터 요소 사이의 간격은 빈번하게는 고정되어 있는 바, 이에 요소가 서로 비교하였을 때, 역위되거나, 이동하는 경우 보존된다. tk 프로모터에서, 프로모터 요소 사이의 간격은 활성 감소가 시작되기 전에 50 bp 떨어져서 증가될 수 있다. 프로모터에 따라서, 이는 개별 요소가 공동으로 작동적으로 또는 독립적으로 작용하여 전사를 활성화시킬 수 있다.
특정 실시양태에서, 바이러스 프로모터, 예컨대, 인간 사이토메갈로바이러스 (CMV) 즉시 조기 유전자 프로모터, SV40 조기 프로모터, 라우스 육종 바이러스 긴 말단 반복부, 래트 인슐린 프로모터 및 글리세르알데히드-3-포스페이트 데히드로게나제를 사용하여 관심 코딩 서열을 고수준으로 발현시킬 수 있다. 발현 수준이 주어진 목적에 충분하다면, 관심 코딩 서열의 발현을 달성하기 위해 당업계에 널리 공지된 다른 바이러스 또는 포유동물 세포 또는 박테리아 파지 프로모터의 사용 또한 고려된다. 특성이 널리 공지된 프로모터를 사용함으로써, 형질감염 및 형질전환 후 관심 단백질의 발현 수준 및 패턴을 최적화시킬 수 있다. 추가로, 특이적인 생리학적 신호에 대한 반응으로 조절되는 프로모터의 선택은 유전자 생성물의 유도성 발현을 허용할 수 있다.
인핸서는 DNA의 동일한 분자에서 원위부에 위치하는 프로모터로부터 전사를 증가시키는 유전자 요소이다. 인핸서는 프로모터와 매우 유사하게 구조화된다. 즉, 이들은 많은 개별 요소로 구성되며, 이들은 각각은 하나 이상의 전사 단백질에 결합한다. 인핸서와 프로모터 사이의 기본적인 차이는 작동성이다. 인핸서 영역은 전체적으로 원위부에서 전사를 자극할 수 있어야만 하며; 이는 사실상 프로모터 영역 또는 그의 성분 인자일 필요는 없다. 한편, 프로모터는 특정 부위 및 특히 배향에서 RNA 합성의 개시를 지시하는 하나 이상의 요소를 가져야 하는 반면, 인핸서에는 이러한 특이성은 없다. 프로모터 및 인핸서는 대개 매우 유사한 모듈러 조직화를 갖는 것으로 보이며, 중복성이고, 연속적이다.
하기는 발현 구축물내 관심 유전자를 코딩하는 핵산과 함께 사용될 수 있는 프로모터/인핸서 및 유도성 프로모터/인핸서의 목록이다. 추가로, 임의의 프로모터/인핸서 조합 (진핵성 프로모터 데이터베이스(Eukaryotic Promoter Data Base) EPDB에 따라) 또한 유전자의 발현을 구동시키는 데 사용될 수 있다. 진핵 세포는 적절한 박테리아 폴리머라제가 전달 복합체의 일부로서 또는 추가의 유전자 발현 구축물로서 제공되는 경우, 특정의 박테리아 프로모터로부터의 세포질성 전사를 지원할 수 있다.
프로모터 및/또는 인핸서는 예를 들어, 면역글로불린 경쇄, 면역글로불린 중쇄, T-세포 수용체, HLA DQ a 및/또는 DQ β, β-인터페론, 인터루킨-2, 인터루킨-2 수용체, MHC 부류 II 5, MHC 부류 II HLA-Dra, β-액틴, 근육 크레아틴 키나제 (MCK), 프리알부민 (트랜스티레틴), 엘라스타제 I, 메탈로티오네인 (MTII), 콜라게나제, 알부민, α-페토단백질, t-글로빈, β-글로빈, c-fos, c-HA-ras, 인슐린, 신경 세포 부착 분자 (NCAM), α1-안티트리파인, H2B (TH2b) 히스톤, 마우스 및/또는 제I형 콜라겐, 글루코스-조절된 단백질 (GRP94 및 GRP78), 래트 성장 호르몬, 인간 혈청 아밀로이드 A (SAA), 트로포닌 I (TN I), 혈소판-유래 성장 인자 (PDGf), 뒤센 근 이영양증, SV40, 폴리오마, 레트로바이러스, 유두종 바이러스, B형 간염 바이러스, 인간 면역결핍증 바이러스, 사이토메갈로바이러스 (CMV), 및 긴팔 원숭이 백혈병 바이러스일 수 있다.
일부 실시양태에서, 유도성 요소가 사용될 수 있다. 일부 실시양태에서, 유도성 요소는 예를 들어, MTII, MMTV (마우스 유방 종양 바이러스), β-인터페론, 아데노바이러스 5 E2, 콜라게나제, 스트로멜리신, SV40, 뮤린 MX 유전자, GRP78 유전자, α-2-마크로글로불린, 비멘틴, MHC 부류 I 유전자 H-2κb, HSP70, 프롤리페린, 종양 괴사 인자, 및/또는 갑상선 자극 호르몬 유전자이다. 일부 실시양태에서, 유도인자는 포르볼 에스테르 (TFA), 중금속, 글루코코르티코이드, 폴리(rI)x, 폴리(rc), ElA, 포르볼 에스테르 (TPA), 인터페론, 뉴캐슬 질환 바이러스(Newcastle Disease Virus), A23187, IL-6, 혈청, 인터페론, SV40 거대 T 항원, PMA, 및/또는 갑상선 호르몬이다. 본원에 기술된 유도성 요소 중 임의의 것이 본원에 기술된 유도인자 중 임의의 것과 함께 사용될 수 있다.
특히 관심의 대상이 되는 것은 근육 특이적 프로모터이다. 이는 미오신 경쇄-2 프로모터, α-액틴 프로모터, 트로포닌 1 프로모터; Na+/Ca2 + 교환체 프로모터, 디스트로핀 프로모터, α7 인테그린 프로모터, 뇌 나트륨뇨설의 펩티드 프로모터, 및 αB-결정질/소형 열 쇼크 단백질 프로모터, α-미오신 중쇄 프로모터, 및 ANF 프로모터를 포함한다. 일부 실시양태에서, 근육 특이적 프로모터 CK8 프로모터이다. CK8 프로모터는 하기 서열 (서열번호: 874)을 갖는다:
Figure pct00010
일부 실시양태에서, 근육 세포 세 특이적 프로모터는 CK8e로 명명되는, CK8 프로모터의 변이체이다. CK8e 프로모터는 하기 서열 (서열번호: 875)을 갖는다:
Figure pct00011
cDNA 삽입체가 사용되는 경우, 전형적으로는 유전자 전사체의 적절한 폴리아데닐화를 달성하기 위한 폴리아데닐화 신호를 포함하는 것이 바람직할 것이다. 예컨대, 인간 성장 호르몬 및 SV40 폴리아데닐화 신호와 같은 임의의 폴리아데닐화 서열이 사용될 수 있다. 또한 발현 카세트의 요소로서 종결인자가 고려된다. 이들 요소는 전령 수준을 증강시키고, 카세트로부터 다른 서열로의 번역초과를 최소화시키는 작용을 할 수 있다.
치료 조성물
AAV - Cas9 벡터
일부 실시양태에서, Cas9는 AAV 벡터 내로 패키징될 수 있다. 일부 실시양태에서, AAV 벡터는 야생형 AAV 벡터이다. 일부 실시양태에서, AAV 벡터는 하나 이상의 돌연변이를 함유한다. 일부 실시양태에서, AAV 벡터는 혈청형 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 및 양 AAV 또는 그의 임의 조합의 AAV 벡터로부터 단리 또는 유래된 것이다.
예시적인 AAV-Cas9 벡터는 Cas9 서열을 포함하는 중심 서열 영역 측면에 위치하는 2개의 ITR (역위 말단 반복) 서열을 함유한다. 일부 실시양태에서, ITR은 혈청형 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 및 양 AAV 또는 그의 임의 조합의 AAV 벡터로부터 단리 또는 유래된 것이다. 일부 실시양태에서, ITR은 AAV 혈청형에 대한 전장 및/또는 야생형 서열을 포함하거나, 또는 그로 구성된다. 일부 실시양태에서, ITR은 AAV 혈청형에 대한 말단절단된 서열을 포함하거나, 또는 그로 구성된다. 일부 실시양태에서, ITR은 AAV 혈청형에 대한 연장된 서열을 포함하거나, 또는 그로 구성된다. 일부 실시양태에서, ITR은 동일한 AAV 혈청형에 대한 야생형 서열과 비교하여 서열 변이를 포함하는 서열을 포함하거나, 또는 그로 구성된다. 일부 실시양태에서, 서열 변이는 치환, 결실, 삽입, 역위, 또는 전좌 중 하나 이상의 것을 포함한다. 일부 실시양태에서, ITR은 적어도 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149 또는 150개의 염기쌍을 포함하거나, 또는 그로 구성된다. 일부 실시양태에서, ITR은 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149 또는 150개의 염기쌍을 포함하거나, 또는 그로 구성된다. 일부 실시양태에서, ITR의 길이는 110 ± 10개의 염기쌍 길이이다. 일부 실시양태에서, ITR의 길이는 120 ± 10개의 염기쌍 길이이다. 일부 실시양태에서, ITR의 길이는 130 ± 10개의 염기쌍 길이이다. 일부 실시양태에서, ITR의 길이는 140 ± 10개의 염기쌍 길이이다. 일부 실시양태에서, ITR의 길이는 150 ± 10개의 염기쌍 길이이다. 일부 실시양태에서, ITR의 길이는 115, 145, 또는 141개의 염기쌍 길이이다.
일부 실시양태에서, AAV-Cas9 벡터는 하나 이상의 핵 국재화 신호 (NLS)를 함유할 수 있다. 일부 실시양태에서, AAV-Cas9 벡터는 1, 2, 3, 4, 또는 5개의 핵 국재화 신호를 함유한다. 예시적인 NLS는 c-myc NLS (서열번호: 884), SV40 NLS (서열번호: 885), hnRNPAI M9 NLS (서열번호: 886), 뉴클레오플라스민 NLS (서열번호: 887), 임포르틴-알파로부터의 IBB 도메인의 서열 RMRKFKNKGKDTAELRRRRVEVSVELRKAKKDEQILKRRNV (서열번호: 888), 근종 T 단백질의 서열 VSRKRPRP (서열번호: 889) 및 서열 PPKKARED (서열번호: 890), 인간 p53의 서열 PQPKKKPL (서열번호: 891), 마우스 c-abl IV의 서열 SALIKKKKKMAP (서열번호: 892), 인플루엔자 바이러스 NS1의 서열 DRLRR (서열번호: 893) 및 서열 KQKKRK (서열번호: 894), 간염 바이러스 델타 항원의 서열 RKLKKKIKKL (서열번호: 895) 및 마우스 Mx1 단백질의 서열 REKKKFLKRR (서열번호: 896)을 함유한다. 추가의 허용되는 핵 국재화 신호는 2부 핵 국재화　서열, 예컨대, 인간 폴리(ADP-리보스)폴리머라제의 서열 KRKGDEVDGVDEVAKKKSKK (서열번호: 897) 또는 스테로이드 호르몬 수용체 (인간) 글루코코르티코이드의 서열 RKCLQAGMNLEARKTKK (서열번호: 898)을 포함한다.
일부 실시양태에서, AAV-Cas9 벡터는 벡터의 패키징 및 Cas9의 발현을 촉진시키기 위해 추가의 인자를 포함할 수 있다. 일부 실시양태에서, AAV-Cas9 벡터는 폴리A 서열을 포함할 수 있다. 일부 실시양태에서, 폴리A 서열은 미니-폴리A 서열일 수 있다. 일부 실시양태에서, AAV-CAs9 벡터는 전위 요소를 포함할 수 있다. 일부 실시양태에서, AAV-Cas9 벡터는 조절인자 요소를 포함할 수 있다. 일부 실시양태에서, 조절인자 요소는 활성인자 또는 억제인자를 포함할 수 있다.
일부 실시양태에서, AAV-Cas9는 하나 이상의 프로모터를 함유할 수 있다. 일부 실시양태에서, 하나 이상의 프로모터는 Cas9의 발현을 구동시킨다. 일부 실시양태에서, 하나 이상의 프로모터는 근육-특이적인 프로모터이다. 예시적인 근육-특이적인 프로모터로는 미오신 경쇄-2 프로모터, α-액틴 프로모터, 트로포닌 1 프로모터, Na+/Ca2+ 교환체 프로모터, 디스트로핀 프로모터, α7 인테그린 프로모터, 뇌 나트륨뇨설의 펩티드 프로모터, αB-결정질/소형 열 쇼크 단백질 프로모터, α-미오신 중쇄 프로모터, ANF 프로모터, CK8 프로모터 및 CK8e 프로모터를 포함한다.
일부 실시양태에서, AAV-Cas9 벡터는 효모, 박테리아, 곤충 세포, 또는 포유동물 세포에서의 생산을 위해 최적화될 수 있다. 일부 실시양태에서, AAV-Cas9 벡터는 인간 세포에서의 발현을 위해 최적화될 수 있다. 일부 실시양태에서, AAV-Cas9 벡터는 배큘로바이러스 발현 시스템에서의 발현을 위해 최적화될 수 있다.
AAV - sgRNA 벡터
일부 실시양태에서, 적어도 gRNA를 코딩하는 제1 서열 및 gRNA를 코딩하는 제2 서열은 AAV 벡터 내로 패키징될 수 있다. 일부 실시양태에서, 적어도 gRNA를 코딩하는 제1 서열, gRNA를 코딩하는 제2 서열, 및 gRNA를 코딩하는 제3 서열은 AAV 벡터 내로 패키징될 수 있다. 일부 실시양태에서, 적어도 gRNA를 코딩하는 제1 서열, gRNA를 코딩하는 제2 서열, gRNA를 코딩하는 제3 서열, 및 gRNA를 코딩하는 제4 서열은 AAV 벡터 내로 패키징될 수 있다. 일부 실시양태에서, 적어도 gRNA를 코딩하는 제1 서열, gRNA를 코딩하는 제2 서열, gRNA를 코딩하는 제3 서열, 및 gRNA를 코딩하는 제4 서열은 AAV 벡터 내로 패키징될 수 있다. 일부 실시양태에서, 적어도 gRNA를 코딩하는 제1 서열, gRNA를 코딩하는 제2 서열, gRNA를 코딩하는 제3 서열, gRNA를 코딩하는 제4 서열, 및 gRNA를 코딩하는 제5 서열은 AAV 벡터 내로 패키징될 수 있다. 일부 실시양태에서, gRNA를 코딩하는 서열 다수가 AAV 벡터 내로 패키징된다. 예를 들어, gRNA를 코딩하는 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 또는 20개의 서열이 AAV 벡터 내로 패키징될 수 있다. 일부 실시양태에서, gRNA를 코딩하는 각 서열은 상이한 것이다. 일부 실시양태에서, gRNA를 코딩하는 적어도 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 또는 20개의 서열은 동일한 것이다. 일부 실시양태에서, gRNA를 코딩하는 서열 모두 동일한 것이다.
일부 실시양태에서, AAV 벡터는 야생형 AAV 벡터이다. 일부 실시양태에서, AAV 벡터는 하나 이상의 돌연변이를 함유한다. 일부 실시양태에서, AAV 벡터는 혈청형 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 및 양 AAV 또는 그의 임의 조합의 AAV 벡터로부터 단리 또는 유래된 것이다.
예시적인 AAV-sgRNA 벡터는 sgRNA 서열을 포함하는 중심 서열 영역 측면에 위치하는 2개의 ITR (역위 말단 반복) 서열을 함유한다. 일부 실시양태에서, ITR은 혈청형 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 및 양 AAV 또는 그의 임의 조합의 AAV 벡터로부터 단리 또는 유래된 것이다. 일부 실시양태에서, ITR은 제1 혈청형의 AAV 벡터로부터 단리 또는 유래된 것이고, AAV-sgRNA 벡터의 캡시드 단백질을 코딩하는 서열은 제2 혈청형의 AAV 벡터로부터 단리 또는 유래된 것이다. 일부 실시양태에서, 제1 혈청형 및 제2 혈청형은 동일한 것이다. 일부 실시양태에서, 제1 혈청형 및 제2 혈청형은 동일하지 않은 것이다. 일부 실시양태에서, 제1 혈청형은 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 및 양 AAV이다. 일부 실시양태에서, 제2 혈청형은 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 및 양 AAV이다. 일부 실시양태에서, 제1 혈청형은 AAV2이고, 제2 혈청형은 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 및 양 AAV이다. 일부 실시양태에서, 제1 혈청형은 AAV2이고, 제2 혈청형은 AAV9이다.
일부 실시양태에서, 제1 ITR은 제1 혈청형의 AAV 벡터로부터 단리 또는 유래된 것이고, 제2 ITR은 제2 혈청형의 AAV 벡터로부터 단리 또는 유래된 것이고, AAV-sgRNA 벡터의 캡시드 단백질을 코딩하는 서열은 제3 혈청형의 AAV 벡터로부터 단리 또는 유래된 것이다. 일부 실시양태에서, 제1 혈청형 및 제2 혈청형은 동일한 것이다. 일부 실시양태에서, 제1 혈청형 및 제2 혈청형은 동일하지 않은 것이다. 일부 실시양태에서, 제1 혈청형, 제2 혈청형, 및 제3 혈청형은 동일한 것이다. 일부 실시양태에서, 제1 혈청형, 제2 혈청형, 및 제3 혈청형은 동일하지 않은 것이다. 일부 실시양태에서, 제1 혈청형은 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 또는 양 AAV이다. 일부 실시양태에서, 제2 혈청형은 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 또는 양 AAV이다. 일부 실시양태에서, 제3 혈청형은 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 또는 양 AAV이다. 일부 실시양태에서, 제1 혈청형은 AAV2이고, 제2 혈청형은 AAV4이고, 제3 혈청형은 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, 또는 AAV11이다. 일부 실시양태에서, 제1 혈청형은 AAV2이고, 제2 혈청형은 AAV4이고, 제3 혈청형은 AAV9이다. 예시적인 AAV-sgRNA 벡터는 sgRNA 서열을 포함하는 중심 서열 영역 측면에 위치하는 2개의 ITR (역위 말단 반복) 서열을 함유한다. 일부 실시양태에서, ITR은 혈청형 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 양 AAV 또는 그의 임의 조합의 AAV 벡터로부터 단리 또는 유래된 것이다. 일부 실시양태에서, ITR은 AAV 혈청형에 대한 전장 및/또는 야생형 서열을 포함하거나, 또는 그로 구성된다. 일부 실시양태에서, ITR은 AAV 혈청형에 대한 말단절단된 서열을 포함하거나, 또는 그로 구성된다. 일부 실시양태에서, ITR은 AAV 혈청형에 대한 연장된 서열을 포함하거나, 또는 그로 구성된다. 일부 실시양태에서, ITR은 동일한 AAV 혈청형에 대한 야생형 서열과 비교하여 서열 변이를 포함하는 서열을 포함하거나, 또는 그로 구성된다. 일부 실시양태에서, 서열 변이는 치환, 결실, 삽입, 역위, 또는 전좌 중 하나 이상의 것을 포함한다. 일부 실시양태에서, ITR은 적어도 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149 또는 150개의 염기쌍을 포함하거나, 또는 그로 구성된다. 일부 실시양태에서, ITR은 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149 또는 150개의 염기쌍을 포함하거나, 또는 그로 구성된다. 일부 실시양태에서, ITR의 길이는 110 ± 10개의 염기쌍 길이이다. 일부 실시양태에서, ITR의 길이는 120 ± 10개의 염기쌍 길이이다. 일부 실시양태에서, ITR의 길이는 130 ± 10개의 염기쌍 길이이다. 일부 실시양태에서, ITR의 길이는 140 ± 10개의 염기쌍 길이이다. 일부 실시양태에서, ITR의 길이는 150 ± 10개의 염기쌍 길이이다. 일부 실시양태에서, ITR의 길이는 115, 145, 또는 141개의 염기쌍 길이이다.
일부 실시양태에서, AAV-sgRNA 벡터는 벡터의 패키징 및 sgRNA의 발현을 촉진시키기 위해 추가의 인자를 포함할 수 있다. 일부 실시양태에서, AAV-sgRNA 벡터는 전위 요소를 포함할 수 있다. 일부 실시양태에서, AAV-sgRNA 벡터는 조절인자 요소를 포함할 수 있다. 일부 실시양태에서, 조절인자 요소는 활성인자 또는 억제인자를 포함한다. 일부 실시양태에서, AAV-sgRNA 서열은 비-기능성이거나, 또는 "스터퍼(stuffer)" 서열을 포함할 수 있다. 본 개시내용의 예시적인 스터퍼 서열은 포유동물 (인간 포함)의 게놈 서열과 일부 (0%가 아닌) 동일성 또는 상동성을 가질 수 있다. 대안적으로, 본 개시내용의 예시적인 스터퍼 서열은 포유동물 (인간 포함)의 게놈 서열과 동일성 또는 상동성을 가지지 않을 수 있다. 본 개시내용의 예시적인 스터퍼 서열은 자연적으로 발생된 비-코딩 서열, 또는 대상체에게로의 AAV 벡터 투여 후 전사되지 않거나 번역되지 않은 서열을 포함하거나, 또는 그로 구성될 수 있다.
일부 실시양태에서, AAV-sgRNA 벡터는 효모, 박테리아, 곤충 세포, 또는 포유동물 세포에서의 생산을 위해 최적화될 수 있다. 일부 실시양태에서, AAV-sgRNA 벡터는 인간 세포에서의 발현을 위해 최적화될 수 있다. 일부 실시양태에서, AAV-Cas9 벡터는 배큘로바이러스 발현 시스템에서의 발현을 위해 최적화될 수 있다.
일부 실시양태에서, AAV-sgRNA 벡터는 적어도 하나의 프로모터를 포함한다. 일부 실시양태에서, AAV-sgRNA 벡터는 적어도 2개의 프로모터를 포함한다. 일부 실시양태에서, AAV-sgRNA 벡터는 적어도 3개의 프로모터를 포함한다. 일부 실시양태에서, AAV-sgRNA 벡터는 적어도 4개의 프로모터를 포함한다. 일부 실시양태에서, AAV-sgRNA 벡터는 적어도 5개의 프로모터를 포함한다. 예시적인 프로모터는 예를 들어, 면역글로불린 경쇄, 면역글로불린 중쇄, T-세포 수용체, HLA DQ a 및/또는 DQ β, β-인터페론, 인터루킨-2, 인터루킨-2 수용체, MHC 부류 II 5, MHC 부류 II HLA-Dra, β-액틴, 근육 크레아틴 키나제 (MCK), 프리알부민 (트랜스티레틴), 엘라스타제 I, 메탈로티오네인 (MTII), 콜라게나제, 알부민, α-페토단백질, t-글로빈, β-글로빈, c-fos, c-HA-ras, 인슐린, 신경 세포 부착 분자 (NCAM), α1-안티트리파인, H2B (TH2b) 히스톤, 마우스 및/또는 제I형 콜라겐, 글루코스-조절된 단백질 (GRP94 및 GRP78), 래트 성장 호르몬, 인간 혈청 아밀로이드 A (SAA), 트로포닌 I (TN I), 혈소판-유래 성장 인자 (PDGf), 뒤센 근 이영양증, SV40, 폴리오마, 레트로바이러스, 유두종 바이러스, B형 간염 바이러스, 인간 면역결핍증 바이러스, 사이토메갈로바이러스 (CMV), 및 긴팔 원숭이 백혈병 바이러스를 포함한다. 추가의 예시적인 프로모터로는 U6 프로모터, H1 프로모터, 및 7SK 프로모터를 포함한다.
일부 실시양태에서, gRNA를 코딩하는 서열 또는 게놈 표적 서열은 서열번호: 60-705, 712-862, 및 947-2377로부터 선택되는 서열을 포함한다.
제약 조성물 및 전달 방법
본원에서는 또한 본 개시내용의 하나 이상의 벡터 및/또는 핵산을 포함하는 조성물을 제공한다. 일부 실시양태에서, 조성물은 제약상 허용되는 담체를 추가로 포함한다.
임상 적용을 위해, 제약 조성물은 의도된 적용을 위해 적절한 형태로 제조된다. 일반적으로, 이는 본질적으로, 발열 물질 뿐만 아니라, 인간 또는 동물에 유해할 수 있는 다른 불순물도 함유하지 않는 조성물을 제조함을 포함한다.
약물, 단백질 또는 전달 벡터를 안정화시키고, 표적 세포에 의해 흡수될 수 있도록 하는 데 적절한 염 및 완충제가 사용된다. 본 개시내용의 수성 조성물은 제약으로 허용되는 담체 또는 수성 매질 중에 용해되거나 분산된, 유효량의 약물, 벡터 또는 단백질을 포함한다. "제약상 또는 약리학상 허용되는"이라는 어구는 분자 엔티티 및 조성물이 동물 또는 인간에게 투여될 때, 부작용, 알레르기, 또는 다른 부적당한 반응을 일으키지 않는다는 것을 지칭한다. 본원에서 사용되는 바, "제약상 허용되는 담체"는 인간에게 투여하기에 적합한 제약과 같은 제약의 제제화용으로 허용되는 용매, 완충제, 용액, 분산 매질, 코팅제, 항박테리아제 및 항진균제, 등장성 제제 및 흡수 지연제 등을 포함한다. 제약상 활성 물질에 대한 상기 매질 및 작용제의 용도는 당업계에 널리 공지되어 있다. 본 개시내용의 활성 성분과 비화합성이 아닌 임의의 통상적인 매질 또는 작용제, 치료 조성물에서 그의 용도가 사용될 수 있다. 조성물의 벡터 또는 세포를 불활성화시키지 않는다면, 보충 활성 성분 또한 조성물 내로 도입될 수 있다.
일부 실시양태에서, 본 개시내용의 활성 조성물은 고전적인 제약 제제를 포함할 수 있다. 본 개시내용에 따른 상기 조성물의 투여는 표적 조직이 해당 경로를 통해 이용가능한 한, 임의의 일반적인 경로를 통해 이루어질 수 있지만, 일반적으로는 전신 투여를 포함한다. 이는 경구, 비강, 또는 협측을 포함한다. 대안적으로, 투여는 진피내, 피하, 근육내, 복강내 또는 정맥내 주사에 의해, 또는 근육 조직 내로의 직접 주사에 의해 이루어질 수 있다. 상기 조성물은 일반적으로 상기 기술된 바와 같이, 제약상 허용되는 조성물로서 투여될 수 있다.
활성 화합물은 또한 비경구적으로 또는 복강내로 투여될 수 있다. 예로서, 활성 화합물의 용액은 유리 염기 또는 약리학상 허용되는 염으로서 예컨대, 히드록시프로필셀룰로스와 같은 계면활성제와 적합하게 혼합된 물 중에서 제조될 수 있다. 분산액은 또한 글리세롤, 액체 폴리에틸렌 글리콜, 및 그의 혼합물 중에서 및 오일 중에서 제조될 수 있다. 통상의 보관 및 사용 조건하에서, 상기 제제는 일반적으로 미생물의 성장을 막기 위해 보존제를 함유한다.
주사용으로 적합한 제약 형태는 예를 들어, 멸균 수성 액제 또는 분산제, 및 멸균 주사용 액제 또는 분산제의 즉석 제조를 위한 멸균 분제를 포함한다. 일반적으로, 이러한 제제는 용이한 주사가능성이 존재하는 정도로 멸균성이고 유동성이다. 제제는 제조 및 보관 조건하에서 안정하여야 하고, 박테리아 및 진균과 같은, 미생물의 오염 작용으로부터 보존되어야 한다. 적절한 용매 또는 분산 매질은 예를 들어, 물, 에탄올, 폴리올 (예를 들어, 글리세롤, 프로필렌 글리콜, 및 액체 폴리에틸렌 글리콜 등), 그의 적합한 혼합물, 및 식물성 오일을 함유할 수 있다. 적절한 유동성은 예를 들어, 레시틴과 같은 코팅제를 사용함으로써, 분산제의 경우, 필요한 입자 크기를 유지시킴으로써 및 계면활성제의 사용에 의해 유지될 수 있다. 각종 항박테리아제 및 항진균제, 예를 들어, 파라벤, 클로로부탄올, 페놀, 소르브산, 티메로살 등에 의해 미생물의 작용을 방지할 수 있다. 다수의 경우에서, 등장제, 예를 들어, 당 또는 염화나트륨을 포함하는 것이 바람직할 것이다. 조성물에서 흡수를 지연시키는 작용제, 예를 들어, 알루미늄 모노스테아레이트 및 젤라틴을 사용함으로써 주사용 조성물의 흡수를 연장시킬 수 있다.
멸균 주사용 액제는 원하는 경우, 임의의 다른 성분 (예를 들어, 상기 열거된 것과 같은 성분)과 함께 적절한 양의 활성 성분을 용매 내에 도입시킨 후, 여과 멸균시킴으로써 제조될 수 있다. 일반적으로, 분산제는 각종의 멸균된 활성 성분을 기초 분산 매질, 및 예컨대, 상기 열거된 것과 같은, 원하는 다른 성분을 함유하는 멸균 비히클 내로 도입시킴으로써 제조된다. 멸균 주사용 액제의 제조를 위한 멸균 분제의 경우, 바람직한 제조 방법은 활성 성분(들)과 추가의 원하는 성분으로 이루어진 분제를, 이전에 멸균 여과된 그의 액제로부터 수득하는 진공-건조 및 동결-건조 기술을 포함한다.
일부 실시양태에서, 본 개시내용의 조성물은 중성 또는 염 형태로 제제화된다. 제약상 허용되는 염은 예를 들어, 무기 산 (예컨대, 염산 또는 인산)으로부터, 또는 유기산 (예컨대, 아세트산, 옥살산, 타르타르산, 만델산 등) 등으로부터 유도된 (단백질의 유리 아미노 기로 형성된) 산 부가염을 포함한다. 단백질의 유리 카르복실 기와 함께 형성된 염은 또한 무기 염기 (예컨대, 나트륨, 칼륨, 암모늄, 칼슘, 또는 수산화제2철)로부터, 또는 유기 염기 (예컨대, 이소프로필아민, 트리메틸아민, 히스티딘, 프로카인) 등으로부터 유도될 수 있다.
제제화시, 액제는 바람직하게는 투여 제제와 화합성인 방식으로 및 치료상 효과적인 양으로 투여된다. 제제는 예컨대, 주사용액제, 약물 방출 캡슐 등과 같은 다양한 투여 형태로 용이하게 투여될 수 있다. 수성 액제로 비경구적으로 투여하는 경우, 예를 들어, 액제는 일반적으로, 적합하게 완충처리되고, 액체 희석제는 먼저 예를 들어, 충분한 염수 또는 글루코스와 함께 등장성이 되도록 만든다. 상기 수성 액제는 예를 들어, 정맥내, 근육내, 피하 및 복강내 투여를 위해 사용될 수 있다. 바람직하게, 멸균 수성 매질은 당업자에게 공지되어 있는 바와 같이, 특히, 본 개시내용에 비추어 사용된다. 예시로서, 단일 용량을 1 ml의 등장성 NaCl 용액 중에 용해시키고, 1,000 ml의 대량피하주사 유액에 첨가하거나, 또는 제안된 주입 부위에 주사될 수 있다 (예를 들어, 문헌 ["Remington's Pharmaceutical Sciences" 15th Edition, pages 1035-1038 and 1570-1580] 참조). 필수적으로는 치료받는 대상체의 상태에 따라 투여량은 일부 변동될 것이다. 투여 담당자는 어느 경우에서든 개인 대상체에 적절한 용량을 결정할 수 있을 것이다. 또한, 인간 투여를 위해서는 제제는 FDA 사무국의 생물학적 제제 표준(FDA Office of Biologics standards)에 의해 요구되는 바와 같이, 멸균성, 발열원성, 일반적인 안전성 및 순도 표준을 충족시켜야 한다.
일부 실시양태에서, 본원에 기술된 Cas9 또는 Cpf1 및 gRNA는 입양 세포 전달 (ACT)을 사용하여 환자에게 전달될 수 있다. 입양 세포 전달시, 하나 이상의 발현 구축물은 생체외에서, 환자 (자가조직의)로부터 또는 환자 이외의 다른 1명 이상의 개체(들) (동종이계)로부터 유래되는 세포에 제공된다. 이어서, 세포는 환자에게 도입되거나 재도입된다. 따라서, 일부 실시양태에서, Cas9 또는 Cpf1을 코딩하는 하나 이상의 핵산 및 디스트로핀 스플라이스 부위를 표적화하는 가이드 RNA는 생체외에서, 세포가 환자에게 도입되거나 재도입되기 전에 세포에 제공된다.
세포 및 세포 조성물
본 개시내용의 하나 이상의 핵산을 포함하는 세포 또한 제공한다. 일부 실시양태에서, 세포는 인간 세포이다. 일부 실시양태에서, 세포는 근육 세포 또는 성상세포 세포이다. 일부 실시양태에서, 세포는 유도 만능성 줄기 (iPS) 세포이다. 일부 실시양태에서, 세포는 심근세포이다. 일부 실시양태에서, 세포 (예컨대, 심근세포)는 iPS 세포로부터 유래된 것이다.
본 개시내용의 하나 이상의 벡터를 포함하는 조성물을 포함하는 세포 또한 제공한다. 일부 실시양태에서, 세포는 인간 세포이다. 일부 실시양태에서, 세포는 근육 세포 또는 성상세포 세포이다. 일부 실시양태에서, 세포는 유도 만능성 줄기 (iPS) 세포이다. 일부 실시양태에서, 세포는 심근세포이다. 일부 실시양태에서, 세포 (예컨대, 심근세포)는 iPS 세포로부터 유래된 것이다.
본 개시내용의 하나 이상의 방법에 의해 제조된 세포 또한 제공한다. 일부 실시양태에서, 세포는 인간 세포이다. 일부 실시양태에서, 세포는 근육 세포 또는 성상세포 세포이다. 세포는 유도 만능성 줄기 (iPS) 세포이다. 일부 실시양태에서, 세포는 심근세포이다. 일부 실시양태에서, 세포 (예컨대, 심근세포)는 iPS 세포로부터 유래된 것이다.
본 개시내용의 하나 이상의 핵산을 포함하는 세포를 포함하는 조성물 또한 제공한다. 일부 실시양태에서, 조성물은 제약상 허용되는 담체를 추가로 포함한다.
치료 방법 및 용도
본 개시내용은 세포에서 디스트로핀 유전자, 예컨대, 돌연변이체 디스트로핀 유전자를 편집하는 방법을 제공한다. 일부 실시양태에서, 세포는 인간 세포이다. 일부 실시양태에서, 세포는 근육 세포 또는 성상세포 세포이다. 세포는 유도 만능성 줄기 (iPS) 세포이다. 일부 실시양태에서, 세포는 심근세포이다. 일부 실시양태에서, 세포 (예컨대, 심근세포)는 iPS 세포로부터 유래된 것이다.
일부 실시양태에서, 본 개시내용은 심근세포를, Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및 gRNA, 또는 gRNA를 코딩하는 서열과 접촉시키는 단계를 포함하고, 여기서, gRNA는 디스트로핀 유전자의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하는 것인, 심근세포에서 돌연변이체 디스트로핀 유전자를 편집하는 방법을 제공한다. 돌연변이체 디스트로핀 유전자는 하나 이상의 돌연변이, 예컨대, 점 돌연변이 (예컨대, 슈도엑손 돌연변이), 결실, 및/또는 중복 돌연변이를 포함할 수 있다. 결실은 적어도 20, 적어도 50, 적어도 100, 적어도 500, 적어도 1000, 적어도 3000개의 뉴클레오티드, 적어도 5000개의 뉴클레오티드 또는 적어도 10,000개의 뉴클레오티드의 결실일 수 있다. 일부 실시양태에서, 결실은 하나 이상의 엑손, 하나 이상의 인트론, 또는 한 인트론 및 한 엑손의 적어도 일부의 결실을 포함한다.
일부 실시양태에서, 본 개시내용은 뒤센 근 이영양증 (DMD) 치료 또는 예방을 필요로 하는 대상체에게 Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및 gRNA, 또는 gRNA를 코딩하는 서열을 투여하는 단계를 포함하고, 여기서, gRNA는 디스트로핀 유전자의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하고; 여기서, 투여는 대상체의 심근세포의 적어도 10%에서 디스트로핀 발현을 회복시키는 것인, DMD 치료 또는 예방을 필요로 하는 대상체에서 DMD를 치료 또는 예방하는 방법을 제공한다. 일부 실시양태에서, 투여는 대상체의 심근세포의 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 적어도 90%, 또는 적어도 95%에서 디스트로핀 발현을 회복시킨다. 평균 인간 심장은 대략 2 내지 30억 개의 심근세포를 갖는다. 따라서, 일부 실시양태에서, 투여는 적어도 2 x 108, 적어도 3 x 108, 적어도 4 x 108, 적어도 5 x 108, 적어도 6 x 108, 적어도 7 x 108, 적어도 8 x 108, 적어도 9 x 108, 적어도 10 x 108, 적어도 11 x 108, 적어도 12 x 108, 적어도 13 x 108, 적어도 14 x 108, 적어도 15 x 108, 적어도 16 x 108, 적어도 17 x 108, 적어도 18 x 108, 적어도 19 x 108, 적어도 20 x 108, 적어도 21 x 108, 적어도 22 x 108, 적어도 23 x 108, 적어도 24 x 108, 적어도 25 x 108, 적어도 26 x 108, 적어도 27 x 108, 적어도 28 x 108, 적어도 29 x 108, 적어도 30 x 108개의 대상체의 심근세포에서 디스트로핀 발현을 회복시킨다. 일부 실시양태에서, 대상체는 확장성 심근증을 앓는다. 일부 실시양태에서, 투여는 적어도 부분적으로 심수축성을 구제하거나, 또는 완전히 심수축성을 구제한다.
일부 실시양태에서, 유도 만능성 줄기 세포 (iPSc)를, Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및 gRNA, 또는 gRNA를 코딩하는 서열과 접촉시키는 단계로서, 여기서, gRNA는 디스트로핀 유전자의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하는 것인 단계; iPSC를 심근세포로 분화시키는 단계; 및 심근세포를 뒤센 근 이영양증 (DMD) 치료 또는 예방을 필요로 하는 대상체에게 투여하는 단계를 포함하는, DMD 치료 또는 예방을 필요로 하는 대상체에서 DMD를 치료 또는 예방하는 방법을 제공한다. 일부 실시양태에서, 적어도 1 x 103, 적어도 1 x 104, 적어도 1 x 105, 적어도 1 x 106, 적어도 1 x 107 또는 적어도 1 x 108개의 심근세포가 환자에게 투여된다.
gRNA는 예를 들어, 심근세포 디스트로핀 유전자의 엑손 51, 45, 53, 44, 46, 52, 50, 43, 6, 7, 8, 또는 55의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화할 수 있다. 일부 실시양태에서, gRNA 또는 게놈 표적화 서열은 서열번호: 60-705, 712-862, 947-2377 중 어느 하나의 서열을 갖는다. cas9 뉴클레아제는 예를 들어, S. 피오게네스 (spCas9) 또는 S. 아우레우스 cas9 (saCas9)로부터 단리되거나, 또는 그로부터 유래된 것일 수 있다.
일부 실시양태에서, gRNA, 또는 gRNA를 코딩하는 서열을 포함하는 벡터를 심근세포와 접촉시킨다. 벡터는 예를 들어, 비-바이러스 벡터, 예컨대, 플라스미드 또는 나노입자일 수 있다. 일부 실시양태에서, 벡터는 바이러스 벡터, 예컨대, 아데노-연관 바이러스 (AAV) 벡터일 수 있다. 일부 실시양태에서, AAV 벡터는 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 및 양 AAV로부터 선택된다.
일부 실시양태에서, Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및 gRNA, 또는 gRNA를 코딩하는 서열을 포함하는 단일 벡터를 심근세포와 접촉시킨다. 다른 실시양태에서, Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열을 포함하는 제1 벡터 및 gRNA, 또는 gRNA를 코딩하는 서열을 포함하는 제2 벡터를 심근세포와 접촉시킨다. 제1 및 제2 벡터는 동일한 벡터일 수 있거나, 또는 상이한 벡터일 수 있다. 예를 들어, 제1 벡터 및 제2 벡터 둘 모두 AAV일 수 있거나, 또는 제1 벡터는 AAV일 수 있고, 제2 벡터는 플라스미드일 수 있다.
가이드 RNA, Cas9 단백질, 또는 그의 뉴클레아제 도메인의 발현에 적합한 조건하에 세포를 본 개시내용의 하나 이상의 조성물과 접촉시키는 단계를 포함하고, 여기서, 가이드 RNA는 Cas9 단백질, 또는 그의 뉴클레아제 도메인과 복합체를 형성하여 적어도 하나의 가이드 RNA-Cas9 복합체를 형성하고, 여기서, 적어도 하나의 가이드 RNA-Cas9 복합체는 디스트로핀 스플라이스 부위를 파괴시키고, DMD 엑손의 선택적 스키핑 및/또는 리프레이밍을 유도하는 것인, 디스트로핀 결함을 교정하는 방법 또한 제공한다. 일부 실시양태에서, 적어도 하나의 가이드 RNA-Cas9 복합체는 디스트로핀 스플라이스 부위를 파괴시키고, 디스트로핀 리딩 프레임의 리프레이밍을 유도한다. 일부 실시양태에서, 적어도 하나의 가이드 RNA-Cas9 복합체는 디스트로핀 스플라이스 부위를 파괴시키고, 디스트로핀 단백질 리딩 프레임을 회복시키는 삽입을 생성한다. 일부 실시양태에서, 삽입은 단일 아데노신의 삽입을 포함한다.
가이드 RNA 및 Cas9 단백질, 또는 그의 뉴클레아제 도메인의 발현에 적합한 조건하에 세포를 본 개시내용의 하나 이상의 조성물과 접촉시키는 단계를 포함하고, 여기서, 가이드 RNA 및 제2 가이드 RNA가 Cas9 단백질, 또는 그의 뉴클레아제 도메인과 복합체를 형성하여 적어도 하나의 가이드 RNA-Cas9 복합체를 형성하고, 여기서, 적어도 하나의 가이드 RNA-Cas9 복합체는 디스트로핀 스플라이스 부위를 파괴시키고, DMD 엑손의 선택적 스키핑 및/또는 리프레이밍을 유도하는 것인, DMD 엑손의 선택적 스키핑 및/또는 리프레이밍을 유도하는 방법 또한 제공한다.
가이드 RNA 및 Cas9 단백질, 또는 그의 뉴클레아제 도메인의 발현에 적합한 조건하에 세포를 본 개시내용의 하나 이상의 조성물과 접촉시키는 단계를 포함하고, 여기서, 가이드 RNA가 Cas9 단백질, 또는 그의 뉴클레아제 도메인과 복합체를 형성하여 적어도 하나의 가이드 RNA-Cas9 복합체를 형성하고, 여기서, 가이드 RNA-Cas9 복합체는 디스트로핀 스플라이스 부위를 파괴시키고, DMD 엑손의 선택적 스키핑 및/또는 리프레이밍을 유도하는 것인, 디스트로핀 리딩 프레임에서 리프레이밍 이벤트를 유도하는 방법 또한 제공한다. 일부 실시양태에서, 적어도 하나의 가이드 RNA-Cas9 복합체는 디스트로핀 스플라이스 부위를 파괴시키고, 인간 DMD 유전자의 엑손 51의 선택적 스키핑 및/또는 리프레이밍을 유도한다.
근 이영양증 치료 또는 예방을 필요로 하는 대상체에게 치료 유효량의 본 개시내용의 하나 이상의 조성물을 투여하는 단계를 포함하는, 근 이영양증 치료 또는 예방을 필요로 하는 대상체에서 근 이영양증을 치료 또는 예방하는 방법 또한 제공한다. 일부 실시양태에서, 조성물은 국소적으로 투여된다. 일부 실시양태에서, 조성물은 근육 조직으로 직접 투여된다. 일부 실시양태에서, 조성물은 근육내 주입 또는 주사에 의해 투여된다. 일부 실시양태에서, 근육 조직은 전경골근 조직, 사두근 조직, 비장근 조직, 횡격막 조직, 또는 심장 조직을 포함한다. 일부 실시양태에서, 조성물은 심장내 주사에 의해 투여된다. 일부 실시양태에서, 조성물은 전신으로 투여된다. 일부 실시양태에서, 조성물은 정맥내 주입 또는 주사에 의해 투여된다. 일부 실시양태에서, 조성물의 투여 후, 대상체는 정상의 디스트로핀-양성 근섬유, 및 중심화된 핵을 함유하는 모자이크 디스트로핀-양성 근섬유, 또는 그의 조합을 나타낸다. 일부 실시양태에서, 조성물 투여 후, 대상체는 조성물 투여 전 정상적인 디스트로핀-양성 근섬유의 부재 또는 그의 존재비 수준과 비교하여 정상적인 디스트포린-양성 근섬유의 출현 또는 그의 존재비 수준 증가를 나타낸다. 일부 실시양태에서, 조성물 투여 후, 대상체는 조성물 투여 전 중심화된 핵을 함유하는 모자이크 디스트로핀-양성 근섬유의 부재 또는 그의 존재비 수준과 비교하여 중심화된 핵을 함유하는 모자이크 디스트로핀-양성 근섬유의 출현 또는 그의 존재비 수준 증가를 나타낸다. 일부 실시양태에서, 조성물 투여 후, 대상체는 조성물 투여 전 혈청 CK 수준과 비교하여 감소된 혈청 CK 수준을 나타낸다. 일부 실시양태에서, 조성물 투여 후, 대상체는 조성물 투여 전 악력과 비교하여 개선된 악력을 나타낸다. 일부 실시양태에서, 대상체는 신생아, 영아, 아동, 청소년, 또는 성인이다. 일부 실시양태에서, 대상체는 근 이영양증을 앓는 것이다. 일부 실시양태에서, 대상체는 근 이영양증에 대한 유전자 보유자이다. 일부 실시양태에서, 대상체는 남성이다. 일부 실시양태에서, 대상체는 여성이다. 일부 실시양태에서, 대상체는 무증상인 것으로 보이고, 유전자 진단을 통해 DMD 유전자 생성물의 기능을 손상시키는 DMD 유전자의 한 카피 또는 두 카피 모두에서에서의 돌연변이가 밝혀진다. 일부 실시양태에서, 대상체는 근 이영양증의 조기 징후 또는 증상을 나타낸다. 일부 실시양태에서, 근 이영양증의 조기 징후 또는 증상으로 근육량의 손실 또는 근위 근육 약화를 포함한다. 일부 실시양태에서, 근육량의 손실 또는 근위 근육 약화는 한쪽 다리 또는 양쪽 다리(들) 모두 및/또는 골반, 이어서, 하나 이상의 상체 근육(들)에서 발생한다. 일부 실시양태에서, 근 이영양증의 조기 징후 또는 증상으로는 가성비대, 낮은 지구력, 직립 곤란, 보행 곤란, 계단 오르기 곤란 또는 그의 조합을 추가로 포함한다. 일부 실시양태에서, 대상체는 근 이영양증의 점진적 징후 또는 증상을 나타낸다. 일부 실시양태에서, 근 이영양증의 점진적 징후 또는 증상으로는 근육 조직 소모, 근육 조직의 지방으로의 교체, 또는 근육 조직의 섬유성 조직으로의 교체를 포함한다. 일부 실시양태에서, 대상체는 근 이영양증의 말기 징후 또는 증상을 나타낸다. 일부 실시양태에서, 근 이영양증의 말기 징후 또는 증상으로는 비정상적인 골 발달, 척추 만곡, 운동 손실, 및 마비를 포함한다. 일부 실시양태에서, 대상체는 근 이영양증의 신경학적 징후 또는 증상을 나타낸다. 일부 실시양태에서, 근 이영양증의 신경학적 징후 또는 증상으로는 지적 장애 및 마비를 포함한다. 일부 실시양태에서, 조성물 투여는 대상체가 근 이영양증의 하나 이상의 점진적, 말기, 또는 신경학적 징후 또는 증상을 나타내기 이전에 진행된다. 일부 실시양태에서, 대상체는 18세 초과, 25세 초과, 또는 30세 초과이다. 일부 실시양태에서, 대상체는 18세 미만, 16세 미만, 12세 미만, 10세 미만, 5세 미만, 또는 2세 미만이다. 근 이영양증 치료를 필요로 하는 대상체에서 근 이영양증을 치료하기 위한, 치료 유효량의 본 개시내용의 하나 이상의 조성물의 용도 또한 제공한다.
전달 벡터
발현 벡터가 세포 내로 도입될 수 있는 방법은 다수 존재한다. 특정 실시양태에서, 발현 구축물은 바이러스 게놈으로부터 유래된 바이러스 또는 조작된 구축물을 포함한다. 수용체-매개 세포내이입을 통해 세포 내로 진입하고, 숙주 세포 게놈 내로 통합되고, 바이러스 유전자를 안정하고 효율적으로 발현시키는 특정 바이러스의 능력에 기인하여 바이러스는 외부 유전자를 포유동물 세포 내로 전달하는 데 있어 관심의 대상이 되는 후보물질이 될 수 있다. 이는 외부 DNA 서열에 대해 비교적 낮은 능력을 가지며, 제한된 숙주 스펙트럼을 갖는다. 추가로, 허용되는 세포에서 그의 발암성인 잠재적이고, 세포병리학적인 효과는 안전성에 관한 우려를 제기한다. 이들은 단지 최대 8 kB의 외부 유전 물질을 수용하지만, 다양한 세포주 및 실험실 동물에 쉽게 도입될 수 있다.
생체내 전달을 위한 바람직한 방법들 중 하나는 아데노바이러스 발현 벡터의 사용을 포함한다. "아데노바이러스 발현 벡터"는 구축물의 패키징을 지원하고, (b) 여기서 클로닝된 안티센스 폴리뉴클레오티드를 발현하기에 충분한 아데노바이러스 서열을 함유하는 구축물을 포함함을 의미한다. 이와 관련하여, 발현은 유전자 생성물이 합성되는 것을 필요로 하지 않는다.
발현 벡터는 아데노바이러스의 유전적으로 조작된 형태를 포함한다. 36 kB의, 선형 이중 가닥 DNA 바이러스인 아데노바이러스의 유전자 조직화에 관한 정보를 통해 큰 조각의 아데노바이러스 DNA를 최대 7 kB의 외부 서열로 치환할 수 있다. 레트로바이러스와 달리, 숙주 세포의 아데노바이러스 감염은 아데노바이러스 DNA가 잠재적인 유전독성없이 에피솜 방식으로 복제할 수 있기 때문에 염색체 통합을 일으키지 않는다. 또한, 아데노바이러스는 구조적으로 안정적이고, 대규모 증폭 후 게놈 재배열이 검출되지 않는다. 아데노바이러스는 그의 세포 주기 단계와는 상관없이 실제로 모든 상피 세포를 감염시킬 수 있다. 지금까지, 아데노바이러스 감염은 인간에서 예컨대, 급성 호흡기 질환과 같은 경증 질환에만 연관이 있는 것으로 보여지고 있다.
아데노바이러스는 그의 중간 크기인 게놈, 조작의 용이성, 높은 역가, 광범위한 표적 세포 범위 및 고감염성으로 인하여 유전자 전달 벡터로서 사용하기에 특히 적합하다. 바이러스 게놈의 양 말단 모두 100-200개의 염기쌍의 역위 반복부 (ITR)를 포함하며, 이는 바이러스 DNA 복제 및 패키징에 필수적인 시스 요소이다. 게놈의 조기 (e) 및 후기 (L) 영역은 바이러스 DNA 복제의 발생에 의해 분할된 상이한 전사 단위를 함유한다. E1 영역 (E1A 및 E1b)은 바이러스 게놈 및 소수의 세포 유전자의 전사의 조절을 담당하는 단백질을 코딩한다. E2 영역 (E2A 및 E2b)의 발현은 바이러스 DNA 복제를 위한 단백질의 합성을 야기한다. 이들 단백질은 DNA 복제, 후기 유전자 발현 및 숙주 세포 셧-오프(shut-off)에 관여한다. 대부분의 바이러스 캡시드 단백질을 포함하는, 후기 유전자의 생성물은 주요 후기 프로모터 (MLP)에 의해 비롯된 단일 1차 전사체의 유의적인 프로세싱 후에만 발현된다. MLP (16.8 m.u.에 위치)는 특히 감염 후기 단계 동안에 효율적이며, 이러한 프로모터로부터 비롯된 mRNA 모두는 이들을 번역에 바람직한 mRNA로 만드는 5'-트리파타이트 리더 (TPL) 서열을 지닌다. 한 시스템에서, 재조합 아데노바이러스는 셔틀 벡터와 프로바이러스 벡터 사이의 상동성 재조합으로부터 생성된다. 두 프로바이러스 벡터 사이의 가능한 재조합에 기인하여, 야생형 아데노바이러스는 이러한 프로세스로부터 생성될 수 있다. 그러므로, 개별 플라크로부터 바이러스의 단일 클론을 단리하고, 그의 게놈 구조를 조사하는 것이 중요하다.
복제 결핍성인, 현 아데노바이러스 벡터의 생성 및 증식은 293으로 지정된 유일한 헬퍼 세포주에 의존하며, 이는 인간 배아 신장 세포로부터 Ad5 DNA 단편에 의해 형질전환되어 E1 단백질을 구성적으로 발현하였다. E3 영역이 아데노바이러스 게놈으로부터 불필요하므로, 현 아데노바이러스 벡터는, 293 세포의 도움으로, E1, D3 영역 또는 두 영역 모두에 외부 DNA를 보유한다. 실제로, 아데노바이러스는 야생형 게놈의 대략 105%를 패키징할 수 있으며, 추가로 약 2 kb의 DNA에 대한 능력을 제공한다. E1 및 E3 영역에서 교체가능한 대략 5.5 kb의 DNA와 조합함으로써, 현 아데노바이러스 벡터의 최대 능력은 7.5 kb, 또는 벡터 총 길이의 약 15%이다. 80% 초과의 아데노바이러스 바이러스 게놈은 벡터 백본 내에 그대로 유지되고, 벡터 유래된 세포독성의 공급원이다. 또한, E1-결실된 바이러스의 복제 결핍성은 불완전하다.
헬퍼 세포주는 인간 배아 신장 세포, 근육 세포, 조혈 세포 또는 다른 인간 배아 중간엽 또는 상피 세포와 같이 인간 세포로부터 유래된 것일 수 있다. 대안적으로, 헬퍼 세포는 인간 아데노바이러스에 대해 허용성인 다른 포유동물 종의 세포로부터 유래될 수 있다. 상기 세포는 예컨대, Vero 세포 또는 다른 원숭이 배아 중간엽 또는 상피 세포를 포함한다. 상기 기술된 바와 같이, 바람직한 헬퍼 세포주는 293이다.
293 세포를 배양하고, 아데노바이러스를 증식시키는 개선된 방법은 당업계에 공지되어 있다. 한 포맷에서, 천연 세포 응집체는 개별 세포를 100-200 ml의 배지를 함유하는 1 ℓ의 실리콘 처리된 스피너 플라스크 (테크네(Techne: 영국 캠프릿지) 내로 접종함으로써 성장시킨다. 40 rpm으로 교반한 후, 세포 생존능을 트립판 블루로 추정한다. 또 다른 포맷에서, 피브라-셀(Fibra-Cel) 미세담체 (비비 스털링(Bibby Sterlin: 영국 스톤)) (5 g/ℓ)를 하기와 같이 사용한다. 5 ml의 배지에 재현탁된 세포 접종물을 250 ml의 에를렌마이어 플라스크(Erlenmeyer flask) 중 담체 (50 ml)에 첨가하고, 1 내지 4 h 동안 가끔씩 교반하면서 정지상 상태 그대로 방치한다. 이어서, 배지를 50 ml의 신선한 배지로 교체하고, 진탕을 개시한다. 바이러스 생산을 위해, 세포를 전면생장률이 약 80%가 될 때까지 성장시킨 후, 배지를 (최종 부피의 25%까지) 교체하고, 아데노바이러스를 0.05의 MOI로 첨가한다. 배양물을 밤새도록 정지상으로 방치한 후, 부피를 100%로 증가시키고, 추가의 또 다른 72 h 동안 진탕을 개시한다.
본 개시내용의 아데노바이러스는 복제 결함성이거나, 적어도 조건부로 복제 결함성이다. 아데노바이러스는 42개의 상이한 공지된 혈청형 또는 서브군 A-F 중 임의의 것일 수 있다. 서브군 C의 아데노바이러스 5형은 본 개시내용에서 사용하기 위한 조건부 복제-결함성 아데노바이러스 벡터를 수득하기 위한 바람직한 출발 물질이다.
상기 언급된 바와 같이, 본 개시내용에 따른 전형적인 벡터는 복제 결함성이고, 아데노바이러스 E1 영역은 가지지 않을 것이다. 따라서, 관심 유전자를 코딩하는 폴리뉴클레오티드를 E1-코딩 서열이 제거된 위치에 도입시키는 것이 가장 편리할 것이다. 그러나, 아데노바이러스 서열내 구축물의 삽입 위치는 중요하지 않다. 관심 유전자를 코딩하는 폴리뉴클레오티드는 또한 E3 대체 벡터내 결실된 E3 영역 대신에, 또는 헬퍼 세포주 또는 헬퍼 바이러스가 E4 결함을 보충하는 E4 영역에 삽입될 수 있다.
아데노바이러스는 성장 및 조작하기 용이하고, 시험관내 및 생체내에서 광범위한 숙주 범위를 나타낸다. 이러한 바이러스 군은 고 역가, 예컨대, 1 ml당 109-1012 플라크-형성 단위로 수득될 수 있으며, 고도의 감염성을 띤다. 아데노바이러스의 생활사는 숙주 세포 게놈 내로의 통합을 필요로 하지 않다. 아데노바이러스 벡터에 의해 전달된 외부 유전자는 에피솜이므로, 숙주 세포에 대해 낮는 유전독성을 갖는다. 야생형 아데노바이러스를 사용한 백신접종의 연구에서 부작용은 보고되어 있지 않으며, 이는 생체내 유전자 전달 벡터로서의 그의 안전성 및 치료학적 잠재능을 입증하는 것이다.
아데노바이러스 벡터는 진핵세포 유전자 발현 및 백신 개발에 사용되어 왔다. 동물 연구는 재조합 아데노바이러스가 유전자 요법에 사용될 수 있음을 제안하였다. 재조합 아데노바이러스를 상이한 조직에 투여하는 데 있어서의 연구는 기관 점적주입법, 근육 주사, 말초 정맥내 주사 및 뇌 내로의 정위 접종을 포함한다.
레트로바이러스는 역전사 프로세스에 의해 감염된 세포에서 이들의 RNA를 이중 가닥 DNA로 전환시킬 수 있는 능력을 특징으로 하는 단일 가닥 RNA 바이러스 군이다. 이어서, 생성된 DNA는 프로바이러스로서 세포 염색체 내로 안정적으로 통합되고, 바이러스 단백질의 합성을 지시한다. 통합을 통해 바이러스 유전자 서열은 수용체 세포 및 그의 자손에 유지된다. 레트로바이러스 게놈은 각각 캡시드 단백질, 폴리머라제 효소, 및 외피 성분을 코딩하는 3개의 유전자, gag, pol, 및 env를 함유한다. gag 유전자로부터 상류 방향에서 발견되는 서열은 비리온 내로 게놈을 패키징하기 위한 신호를 함유한다. 2개의 긴 말단 반복 (LTR) 서열은 바이러스 게놈의 5' 및 3' 말단에 존재한다. 이는 강력한 프로모터 및 인핸서 서열을 함유하며, 이는 또한 숙주 세포 게놈내 통합을 위해 요구된다.
레트로바이러스 벡터를 구축하기 위해, 관심 유전자를 코딩하는 핵산을 특정의 바이러스 서열 대신 바이러스 게놈 내로 삽입하여 복제-결함성인 바이러스를 제조한다. 비리온을 생산하기 위해, gag, pol, 및 env 유전자는 함유하지만, LTR 및 패키징 성분은 없는 패키징 세포주를 구축한다. 레트로바이러스 LTR 및 패키징 서열과 함께, cDNA를 함유하는 재조합 플라스미드를 (예를 들어, 인산칼슘 침전에 의해) 상기 세포주 내로 도입하는 경우, 패키징 서열을 통해 재조합체 플라스미드의 RNA 전사체는 바이러스 입자 내로 패키징될 수 있고, 이어서, 배양 배지 내로 분비된다. 이어서, 재조합 레트로바이러스를 함유하는 배지를 수집하고, 임의적으로 농축시키고, 유전자 전달을 위해 사용한다. 레트로바이러스 벡터는 광범위하게 다양한 세포 유형을 감염시킬 수 있다. 그러나, 통합 및 안정적인 발현을 위해서는 숙주 세포의 분열이 요구된다.
락토스 잔기를 바이러스 외피에 화학적으로 첨가함으로써 진행되는 레트로바이러스의 화학적 변형을 기반으로, 레트로바이러스 벡터를 특이적으로 표적화할 수 있도록 디자인된 새로운 접근법이 최근에 개발되었다. 이러한 변형은 시알로당단백질 수용체를 통한 간세포의 특이적인 감염을 허용할 수 있었다.
레트로바이러스 외피 단백질에 대한, 및 특이적인 세포 수용체에 대한 비오티닐화된 항체가 사용되는, 재조합 레트로바이러스를 표적화하기 위한 상이한 접근법을 사용할 수 있다. 항체는 스트렙트아비딘을 사용함으로써 비오틴 성분을 통해 커플링된다. 주요 조직적합성 복합체 제I 부류 및 제II 부류 항원에 대한 항체를 사용하여, 시험관내 동종지향성 바이러스로 이러한 표면 항원을 생성하는 다양한 인간 세포의 감염이 입증되어 왔다.
본 개시내용의 모든 측면에서 레트로바이러스 벡터의 사용에 대한 특정의 제한이 있다. 예를 들어, 레트로바이러스 벡터는 일반적으로 세포 게놈 내에 무작위 부위로 통합된다. 이는 숙주 유전자의 중단을 통해 또는 측면에 위치하는 유전자의 기능을 방해할 수 있는 바이러스 조절 서열의 삽입을 통해 삽입 돌연변이유발을 초래할 수 있다. 결함이 있는 레트로바이러스 벡터를 사용하는 경우에 있어 또 다른 우려는 패키징 세포 내에서 야생형 복제-적격성 바이러스의 잠재적인 출현이다. 이는, 재조합 바이러스로부터의 무손상 서열이 숙주 세포 게놈내 통합된 gag, pol, env 서열로부터 상류에 삽입되는 재조합 이벤트로부터 초래될 수 있다. 그러나, 재조합 가능성을 크게 감소시켜야 하는 새로운 패키징 세포주가 현재 이용가능하다 (예를 들어, 문헌 [Markowitz et al., 1988]; [Hersdorffer et al., 1990] 참조).
다른 바이러스 벡터가 본 개시내용에서 발현 구축물로서 사용될 수 있다. 백시니아 바이러스 아데노-연관 바이러스 (AAV) 및 헤르페스바이러스와 같은 바이러스로부터 유래된 벡터가 사용될 수 있다. 이들은 다양한 포유동물 세포에 대한 수개의 관심가는 특징을 제공한다.
실시양태에서, AAV 벡터는 복제-결합성이거나, 조건부로 복제 결함성이다. 실시양태에서, AAV 벡터는 재조합 AAV 벡터이다. 일부 실시양태에서, AAV 벡터는 혈청형 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 또는 양 AAV 또는 그의 임의 조합의 AAV 벡터로부터 단리되거나 유래된 서열을 포함한다.
일부 실시양태에서, Cas9 또는 Cpf1을 코딩하는 핵산 및 적어도 하나의 gRNA를 세포로 전달하는 데 단일의 바이러스 벡터가 사용된다. 일부 실시양태에서, Cas9 또는 Cpf1은 제1 바이러스 벡터를 사용하여 세포로 제공되고, 적어도 하나의 gRNA는 제2 바이러스 벡터를 사용하여 세포로 제공된다.
일부 실시양태에서, Cas9 또는 Cpf1을 코딩하는 핵산 및 적어도 하나의 gRNA를 세포로 전달하는 데 단일의 바이러스 벡터가 사용된다. 일부 실시양태에서, Cas9 또는 Cpf1은 제1 바이러스 벡터를 사용하여 세포로 제공되고, 적어도 하나의 gRNA는 제2 바이러스 벡터를 사용하여 세포로 제공된다. 센스 또는 안티센스 유전자 구축물을 발현시키기 위해, 발현 구축물을 세포 내로 전달하여야 한다. 세포는 근육 세포, 성상 세포, 메소혈관모세포, 골수 유래된 세포, 기질 세포 또는 중간엽 줄기 세포일 수 있다. 실시양태에서, 세포는 심근 세포, 골격근 세포, 또는 블런트근 세포이다. 실시양태에서, 세포는 전경골근, 사두근, 비장근, 횡격막 또는 심장내 세포이다. 일부 실시양태에서, 세포는 유도 만능성 줄기 세포 (iPSc) 또는 내부 세포괴 세포 (iCM)이다. 추가의 실시양태에서, 세포는 인간 iPSC 또는 인간 iCM이다. 일부 실시양태에서, 본 개시내용의 인간 iPSC 또는 인간 iCM은 배양된 줄기 세포주, 성체 줄기 세포, 태반 줄기 세포, 또는 인간 배아의 파괴를 필요로 하지 않는 성체 또는 배아 줄기 세포의 또 다른 공급원으로부터 유래될 수 있다. 세포로의 전달은 세포주를 형질전환하기 위한 실험실 방법에서와 같이 시험관내에서, 또는 특정의 질환 상태의 치료에서와 같이 생체내 또는 생체외에서 달성될 수 있다. 한 전달 기전은 발현 구축물이 감염성 바이러스 입자 내에 캡시드화되는 바이러스 감염을 통하며 이루어지는 것이다.
배양된 포유동물 세포 내로 발현 구축물을 전달하기 위한 수개의 비-바이러스 방법 또한 본 개시내용에 의해 고려된다. 이는 인산칼슘 침전, DEAE-덱스트란, 전기천공, 직접적인 미세주입, DNA-로딩된 리포솜 및 리포펙타민-DNA 복합체, 세포 초음파, 고속 미세사출을 사용한 유전자 충격, 및 수용체-매개 형질감염을 포함한다. 이러한 기술 중 일부는 생체내 또는 생체외 사용을 위해 성공적으로 적합화될 수 있다.
일단 발현 구축물이 세포 내로 전달되고 나면, 관심 유전자를 코딩하는 핵산을 상이한 부위에 위치시키고, 발현시킬 수 있다. 특정 실시양태에서, 유전자를 코딩하는 핵산은 세포의 게놈 내로 안정하게 통합될 수 있다. 이러한 통합은 상동성 재조합 (유전자 대체)을 통해 동종 위치 및 배향으로 존재할 수 있거나, 또는 무작위의, 비-특이적인 위치 (유전자 증강) 내에 통합될 수 있다. 추가의 또 다른 실시양태에서, 핵산은 DNA의 별개의, 에피솜 세그먼트로서 세포 내에서 안정하게 유지될 수 있다. 상기 핵산 세그먼트 또는 "에피솜"은 숙주 세포 주기와는 독립적으로, 또는 숙주 세포 주기와 동기화된 유지 및 복제를 허용하기에 충분한 서열을 코딩한다. 발현 구축물이 세포로 전달되는 방법 및 세포 내에서 핵산이 유지되는 위치는 사용된 발현 구축물의 유형에 의존한다.
추가의 또 다른 실시양태에서, 발현 구축물은 간단하게 네이키드 재조합 DNA 또는 플라스미드로 구성될 수 있다. 구축물의 전달은 세포막을 물리적으로 또는 화학적으로 투과하는 상기 언급된 방법 중 임의의 것에 의해 수행할 수 있다. 이는 특히 시험관내 전달에 적용가능하지만, 생체내 용도에도 또한 적용될 수 있다.
네이키드 DNA 발현 구축물을 세포로 형질감염시키는 추가의 또 다른 실시양태에서, 입자 충격이 포함될 수 있다. 상기 방법은 DNA-코팅된 미세사출을 고속으로 가속화하여, 세포를 사멸시키지 않으면서, 이들이 세포막을 뚫고, 세포 내로 진입할 수 있도록 하는 능력에 의존한다. 작은 입자를 가속화하는 수개의 장치가 개발되어 왔다. 상기와 같은 한 장치는, 궁극적으로 추진력을 제공하는, 전류를 생성하기 위한 고압 방전에 의존한다. 사용된 미세사출은 예컨대, 텅스텐 또는 금 비드와 같이, 생물학적으로 불활성인 물질로 구성되었다.
일부 실시양태에서, 발현 구축물은 대상체의 간, 피부, 및/또는 근육 조직으로 직접 전달된다. 이는 총과 표적 기관 사이의 개입 조직을 제거하기 위해, 즉, 생체외 치료를 위해 조직 또는 세포의 외과적 노출을 필요로 할 수 있다. 또한, 특정 유전자를 코딩하는 DNA는 본 방법을 통해 전달될 수 있고, 본 개시내용에 추가로 포함될 수 있다.
추가 실시양태에서, 발현 구축물은 리포솜 내에 포획될 수 있다. 리포솜은 인지질 이중층 막 및 내부 수성 매질을 특징으로 하는 소포체 구조이다. 다층판 리포솜은 수성 매질에 의해 분리된 다중의 지질 층을 갖는다. 이들은 인지질이 과량의 수용액 중에 현탁되는 경우에 자발적으로 형성된다. 지질 성분은 밀폐된 구조를 형성하기 전에 자가 재배열되고, 지질 이중층 사이에 물과 용해된 용질을 포획한다. 또한, 리포펙타민-DNA 복합체도 고려된다.
시험관내 외부 DNA의 리포솜-매개 핵산 전달 및 발현은 매우 성공적이었다. 리포펙타민 2000™으로 공지된 시약은 광범위하게 사용되며, 상업적으로 이용가능하다.
특정 실시양태에서, 리포솜은 세포막과의 융합을 촉진시키고, 리포솜-캡슐화된 DNA의 세포 도입을 촉진하기 위해 헤마글루틴화 바이러스 (HVJ)와 복합체를 형성할 수 있다. 다른 실시양태에서, 리포솜은 핵 비-히스톤 염색체 단백질 (HMG-1)과 함께 복합체를 형성할 수 있거나, 또는 사용될 수 있다. 추가의 또 다른 실시양태에서, 리포솜은 HVJ 및 HMG-1, 둘 모두와 함께 복합체를 형성할 수 있거나, 또는 사용될 수 있다. 상기 발현 구축물이 시험관내 및 생체내에서 핵산의 전달 및 발현에 성공적으로 사용되어 왔다는 점에서, 이들은 본 개시내용에 적용가능하다. 박테리아 프로모터가 DNA 구축물에 사용되는 경우, 적절한 박테리아 폴리머라제를 리포솜 내에 포함시키는 것 또한 바람직할 것이다.
특정 유전자를 코딩하는 핵산을 세포 내로 전달하는데 사용될 수 있는 다른 발현 구축물은 수용체-매개 전달 비히클이다. 이는 거의 모든 진핵 세포에서 수용체-매개 세포내이입에 의해 거대분자의 선택적인 흡수를 이용한다. 다양한 수용체의 세포 유형-특이적인 분포로 인하여, 전달은 매우 특이적일 수 있다.
수용체-매개 유전자 표적화 비히클은 일반적으로 2개의 성분: 세포 수용체-특이적 리간드 및 DNA-결합제로 구성된다. 수개의 리간드는 수용체-매개 유전자 전달을 위해 사용되어 왔다. 가장 광범위하게 특징화된 리간드는 아시알로오로소무코이드(asialoorosomucoid: ASOR) 및 트랜스페린이다. ASOR과 동일한 수용체를 인식하는, 합성 네오당단백질이 유전자 전달 비히클로서 사용하여 왔으며, 표피 성장 인자 (EGf) 또한 편평 암종 세포로 유전자를 전달하는 데 사용되어 왔다.
뒤센 근 이영양증
뒤센 근 이영양증 (DMD)은 5,000명의 남아 중 대략 1명에서 발병되는, 열성 X-연관 형태의 근 이영양증이며, 이는 근육 퇴행 및 조기 사망을 야기한다. 상기 장애는, 단백질 디스트로핀 (진뱅크 수탁 번호 AAA53189; 서열번호: 5)을 코딩하는, 인간 X 염색체 상에 위치하는 유전자 디스트로핀 (진뱅크 수탁 번호 NC_000023.11)내 돌연변이에 의해 유발된다.
인간에서, 디스트로핀 mRNA는 79개의 엑손을 함유한다. 디스트로핀 mRNA는 선택적으로 스플라이싱되어 다양한 이소폼으로 생성되는 것으로 알려져 있다. 예시적인 디스트로핀 이소폼이 표 1에 열거되어 있다.
뮤린 디스트로핀 단백질은 하기 아미노산 서열 (유니프로트 수탁 번호(Uniprot Accession No.) P11531, 서열번호: 869)을 갖는다:
Figure pct00012
디스트로핀은 세포막의 디스트로글리칸 복합체 (DGc)에 대해 구조적 안정성을 제공하는 근 조직내의 중요한 성분이다. 두 성별 모두 돌연변이를 보유할 수 있지만, 여성이 골격근 형태의 질환에 걸리는 경우는 드물다.
돌연변이는 성질 및 빈도면에서 다양하다. 큰 유전적 결실은 사례의 약 60-70%에서 발견되며, 큰 중복은 사례의 약 10%에서 발견되고, 점 돌연변이 또는 다른 작은 변이는 사례의 약 15-30%를 차지한다. 일부 7,000개의 돌연변이를 연구한 블라덴(Bladen) 등 (문헌 [Bladen et al. (2015)])은 총 5,682개의 큰 돌연변이 (전체 돌연변이 중 80%)를 분류하였으며, 이중 4,894 (86%)가 결실 (1개의 엑손 또는 그 초과)이고 784개 (14%)는 중복 (1개 엑손 또는 그 초과)이었다. 1,445개의 작은 돌연변이 (1개의 엑손보다 작음, 모든 돌연변이의 20%)가 존재하였으며, 이중 358개 (25%)는 작은 결실이었고, 132개 (9%)는 작은 삽입인 반면, 199개 (14%)는 스플라이스 부위에 영향을 미쳤다. 점 돌연변이는 총 756개 (작은 돌연변이의 52%)였고, 726개 (50%)는 넌센스 돌연변이이고, 30개 (2%)는 미스센스 돌연변이였다. 마지막으로, 22개 (0.3%)의 중간 인트론 돌연변이가 관찰되었다. 추가로, 돌연변이는 정지 코돈 번역초과 요법 (총 돌연변이의 10%) 및 엑손 스키핑 요법 (결실의 80% 및 총 돌연변이의 55%)을 포함하는 DMD에 대한 신규한 유전자 요법으로부터 잠재적으로 이익을 얻을 할 수 있는 데이터베이스 내에서 확인되었다.
DMD 대상체 특징 및 임상 소견
증상은 일반적으로 2 내지 3세 연령 사이의 남아에서 출현하며, 영아 초기에도 가시화될 수 있다. 증상이 영아 초기에 출현하지만, 실험실 시험은 출생시 활성 돌연변이를 보유하는 아동을 확인할 수 있다. 근육량의 손실과 연관된 다리 및 골반의 점진적 근위근 약화가 처음 관찰된다. 결국, 상기 약화는 팔, 목, 및 다른 부위로 확산된다. 조기 징후로는 가성비대 (종아리 및 삼각근의 비대), 낮은 지구력, 및 도움없이는 직립 곤란 또는 계단 오르기 불능을 포함할 수 있다. 병태가 진행됨에 따라, 근육 조직은 소모되고, 결국 지방 및 섬유 조직으로 대체된다 (섬유증). 10세까지, 보행을 보조하기 위해 브레이스(brace)를 필요로 할 수 있지만, 대부분의 환자는 12세까지 휠체어에 의존한다. 말기 증상은 척추의 만곡을 포함하는, 골격 기형을 야기하는 비정상적인 골 발달을 포함할 수 있다. 근육의 점진적 악화로 인하여, 운동 손실이 발생하여, 궁극적으로 마비를 초래한다. 지적 장애가 존재할 수 있거나, 존재하지 않을 수 있지만, 존재하는 경우, 아동이 나이가 들어감에 따라 점진적으로 악화되지는 않는다. DMD를 앓는 남성에 대한 평균 기대 수명은 대략 25세이다.
점진적인 신경근 장애인, 뒤센 근 이영양증의 주요 증상은 근 소모와 연관된 근육 약화이며, 여기서, 수의근, 특히, 둔부, 골반 부위, 넙적다리, 어깨, 및 종아리의 수의근이 가장 먼저 영향을 받는다. 근육 약화는 또한 추후에 팔, 목, 및 다른 부위에서 발생한다. 종아리는 흔히 비대해진다. 증상은 일반적으로 6세 이전에 나타나며 영아 초기에 출현할 수 있다. 다른 신체적 증상은 하기와 같다:
1 부자연스러운 방식의 보행, 걸음, 또는 달리기 - (환자는 증가된 종아리 근 긴장으로 인하여, 그의 전족부로 경향이 있다. 또한, 발가락 보행은 무릎 신근 약화에 대한 보상 적응이다).
2. 빈번하게 넘어짐.
3. 피로.
4. 운동 기술 (달리기, 호핑, 점핑)의 곤란.
5. 가능하게는 둔부-굴근의 단축을 초래하는, 요추 과전만증(lumbar hyperlordosis). 이는 전반적인 자세 및 보행, 걸음, 또는 달리기 방식에 영향을 미친다.
6. 아킬레스 건 및 슬건(hamstring)의 근육 수축은 결합 조직내 근육 섬유의 단축 섬유화로 인하여 기능성을 손상시킨다.
7. 점진적인 보행 곤란.
8. 근육 섬유 변형.
9. 혀 및 종아리 근육의 가성비대 (비대). 근육 조직은 결국 지방 및 결합 조직으로 대체되므로, 용어는 가성비대가 된다.
10. 위험도가 더 높은 고위험의 신경행동 장애 (예컨대, ADHD), 학습 장애 (난독증), 및 특수한 인지 기술 (특히, 단기 언어 기억)에 있어서 비-진행적 약화, 이는 뇌 속에 디스트로핀의 부재 또는 기능장애의 결과인 것으로 여겨진다.
11. 결과적으로 보행 능력의 상실 (일반적으로 12세까지).
12. 골격 변형 (일부 경우에 척추측만증 포함).
13 눕거나, 앉은 자세에서 일어나기 어려움.
이러한 상태는 환자가 자신의 제1 단계에 들어가는 순간에서부터 임상적으로 관찰될 수 있으며, 보행 능력은 일반적으로 남아가 9세 내지 12세가 되는 사이에 완전히 와해된다. DMD를 앓는 대부분의 남성은 21세까지 본질적으로 "목 아래로부터 마비"된다. 근육 소비는 다리 및 골반에서 시작한 후, 어깨 및 목 근육으로 진행하고, 이후, 팔 근육 및 호흡 근육의 손실로 이어진다. 종아리 근육 비대 (가성비대)가 매우 명백하다. 특히 심근증 (확장성 심근증)이 일반적이지만, 울혈성 심부전 또는 부정맥 (불규칙적인 심박동)은 단지 가끔 일어난다.
양성 고워스 징후(Gowers' sign)는 하지 근육의 보다 심각한 중증 손상을 반영한다. 아동은 상지를 이용하여 혼자힘으로 일어나게 되는데; 먼저 자신의 팔 및 무릎에 의존하여 일어난 후, 자신의 손으로 다리를 들어서 똑바로 일어난다. 발병된 아동은 일반적으로 보다 더 쉽게 피로를 느끼고, 그 또래보다 전반적으로 힘이 더 약하다.
혈류 속의 크레아틴 키나제 (CPK-MM) 수준이 극도로 높다. 근전도검사 (EMG)는 약화가 신경에 대한 손상에 의해서라기 보다는 근육 조직의 파괴에 의해 유발됨을 나타낸다. 유전적 검사는 Xp21 유전자내 유전적 오류를 나타낼 수 있다. 근육 생검 (면역조직화학법 또는 면역블롯팅) 또는 유전적 시험 (혈액 검사)은 유전적 시험에 있어서의 개선으로 종종 이는 불필요하지만, 이는 디스트로핀의 부재를 확인한다.
DMD 환자는 하기로부터 고통받을 수 있다:
1. 비정상적인 심근 (심근증).
2. 울혈성 심부전 또는 불규칙적인 심박동 (부정맥).
3. 감스 및 등의 기형 (척추측만증).
4. 종아리, 둔부, 및 어깨 근육 비대 (대략 4 또는 5세). 상기 근육은 결국 지방 및 결합 조직으로 대체된다 (가성비대).
5. 근육량의 손실 (위축증).
6. 발뒷꿈치, 다리에서의 근육 수축.
7. 근육 변형.
8. 폐렴 및 폐내로 유입되는 음식물 또는 유체의 삼킴을 포함하는, 호흡기 장애 (질환의 마지막 단계).
뒤센 근 이영양증 (DMD)은 X 염색체의 짧은 아암에 위치하는, 유전자좌 Xp21에서의 디스트로핀 유전자의 돌연변이에 의해 유발된다. 디스트로핀은 많은 서브유닛을 함유하는 단백질 복합체를 통해, 기초 기저판 (세포외 매트릭스)에 각각의 근육 섬유의 세포골격을 연결시키는 데 관여한다. 디스트로핀의 부재는 과도한 칼슘이 근섬유막 (세포막)을 침투하도록 한다. 칼슘 및 신호전달 경로의 변경은 물이 미토콘드리아 내로 유입되도록 하며, 미토콘드리아는 이후 파열된다.
골격근 이영양증에서, 미토콘드리아 기능장애는 스트레스-유도된 시토졸 칼슘 신호의 증폭 및 스트레스-유도된 반응성-산소종(ROS) 생산의 증폭을 일으킨다. 여러 경로를 포함하고, 명확하게 이해되지 않는 복잡한 캐스캐이딩 프로세스에서, 세포내 증가된 산화 스트레스는 근섬유막을 손상시키고, 결국 세포의 사멸을 야기한다. 근육 섬유는 괴사되어 결국 근섬유막 및 결합 조직으로 대체된다.
DMD는 X-연관 열성 패턴으로 유전된다. 여성은 전형적으로 질환에 대한 보유자가 되겠지만, 남성에서는 발생하게 될 것이다. 전형적으로, 여성 보유자는 그녀의 아들에서 발병될 때까지는 돌연변이를 보유하고 있음을 인지하지 못할 것이다. 엄마가 보유자인 아들이 그의 엄마로부터 결함이 있는 유전자를 유전시킬 확률은 50%이다. 엄마가 보유자인 딸이 보유자가 될 확률은 50%이고, 정상인 2개의 유전자 카피를 가질 확률은 50%이다. 모든 경우에서, 발병되지 않은 아버지는 정상의 Y를 그의 아들에게 전달하거나, 정상의 X를 그의 딸에게 전달할 것이다. 예컨대, DMD와 같은, X-연관 열성 조건의 여성 보유자는 그의 X-불활성화 패턴에 의존하는 증상을 나타낼 수 있다.
프레임 밖의 엑손과 병치함으로써 오픈 리딩 프레인 (ORf)을 파괴하는, 인간 DMD 유전자 유전자의 엑손 51 앞쪽의 엑손 결실은 인간 DMD 돌연변이의 가장 일반적인 유형을 나타낸다. 엑손 51의 스키핑은 원칙적으로 엑손 결실된 DMD 환자의 13%에서 DMD ORF를 회복한다.
남유아에서 뒤센 근 이영양증의 발병률은 5,000명 중 1명이다. 디스트로핀 유전자내 돌연변이는 유전될 수 있거나, 생식세포계열 유전 동안 자발적으로 발생할 수 있다.
서열
하기 표는 본원에 개시된 조성물 및 방법과 함께 사용하기 위한 예시적인 프라이머, gRNA 및 게놈 표적화 서열을 제공한다.
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VII. 실시예
하기 실시예는 본 개시내용의 바람직한 실시양태를 입증하기 위해 포함된다. 하기 실시예에 개시된 기술은 본 개시내용의 실시에서 잘 작용하도록 본 발명자에 의해 발견된 기술을 나타내며, 따라서, 그의 실시를 위한 바람직한 모드를 구성하는 것으로 간주될 수 있음을 당업자는 이해하여야 한다. 그러나, 당업자는 본 개시내용에 비추어, 개시된 구체적인 실시양태에서 다수의 변형이 이루어질 수 있고, 본 개시내용의 정신 및 범주로부터 벗어남이 없이 동일하거나 유사한 결과를 여전히 수득할 수 있음을 이해하여야 한다.
실시예 1
CRISPR/Cas9를 이용한 유전자 편집은 질환 유발 돌연변이를 교정하거나, 또는 완화시키는 유망한 새로운 접근법이다. 뒤센 근 이영양증 (DMD)은 X-연관 디스트로핀 유전자 (DMD) 중의 3,000개 초과의 상이한 돌연변이에 의해 유발되는 심근 및 골격근의 치명적 퇴행과 연관이 있다. 상기 돌연변이는 대부분 "핫스팟"에 군집되어 있다. 진핵성 스플라이스 수용자 및 스플라이스 공여자 서열과, 원핵성 CRISPR/Cas9 표적 유전자 인식 및 절단을 지배하는 프로토스페이서 인접한 모티프 서열은 우연한 일치를 보인다. 이러한 일치를 이용하여, 돌연변이 핫스팟 내의 또는 그 인접부에서의 가장 공통된 돌연변이체 또는 프레임 밖의 DMD 엑손의 스키핑을 잠재적으로 허용하는, 12개의 엑손 중의 보존적 RNA 스플라이스 부위를 폐기하는 삽입/결실(indel) 돌연변이를 비상동성 말단 연결에 의해 도입할 수 있는 최적의 가이드 RNA에 대해 스크리닝하였다. 엑손 스키핑에 의한 DMD 돌연변이 교정은 본원에서 "근편집"으로 지칭한다. 개념 증명 연구에서, DMD 유전자 내에 큰 결실, 점 돌연변이, 또는 중복을 갖는 다수의 환자로부터의 대표적인 유도 만능성 줄기 세포에서 근편집이 수행되었고, 이는 유도 심근세포에서 디스트로핀 단백질 발현을 효율적으로 회복시켰다. 3차원의 조작된 심장 근육 (EHM)에서, DMD 돌연변이의 근편집이 디스트로핀 발현 및 상응하는 기계적 수축 장력을 회복시켰다. 심근세포의 서브세트만 (30 내지 50%)을 교정하는 것도 돌연변이체 EHM 표현형을 거의 정상에 가까운 제어 수준으로까지 구제하는 데에는 충분하였다. 따라서, 보존적 RNA 스플라이싱 수용자/공여자 부위를 폐기하고, 근편집을 통해 돌연변이체 또는 프레임 밖의 엑손을 스키핑하도록 스플라이싱 기구를 유도함으로써 질환의 근본적인 유전적 이유를 제거하여 DMD와 연관된 심장 이상을 교정할 수 있을 것으로 보인다.
DMD 돌연변이의 핫스팟 영역과 연관된 12개의 상이한 엑손을 표적화하는 최적의 가이드 RNA 확인
스키핑되었을 때, 잠재적으로 DMD 돌연변이의 핫스팟 영역 대부분에서 디스트로핀 오픈 리딩 프레임을 회복시킬 수 있는 상위 12개의 엑손에 관한 목록은 표 5에 제시되어 있다. 엑손 스키핑에 의해 인간 DMD 돌연변이 대다수를 교정하기 위한 첫 단계로서, 인간 DMD 유전자의 상이 12개의 엑손을 표적화하는 가이드 RNA 풀을 스크리닝하였다 (도 1a 및 1b). 각 엑손의 3' 또는 5' 스플라이스 부위를 각각 표적화하기 위해 3 내지 6개의 PAM 서열 (NAG 또는 NGG)을 선택하였다 (도 1a 및 표 5). 이들 가이드 RNA를 플라스미드 SpCas9-2A-GFP에서 클로닝하였다. 필수 스플라이스 공여자 또는 수용자 서열을 제거하는 삽입/결실(Indel)을 통해 상응한 표적 엑손을 스키핑할 수 있다. 공지된 DMD 돌연변이의 빈도에 기초하여, 상기 가이드 RNA는 최대 60%의 DMD 환자에서 디스트로핀 기능을 구제할 수 있을 것으로 예측될 것이다.
인간 게놈에서의 상기 전략법의 실현가능성 및 효율을 시험하기 위해, 인간 배아 신장 293 세포 (239 세포)를 사용하여 엑손 51의 스플라이스 수용자 부위를 표적화하였다 (도 1c). 형질감염된 293 세포를 녹색 형광 단백질 (GFP) 발현에 의해 분류하고, 미스매치-특이적인 T7E1 엔도뉴클레아제 검정법에 의해 유전자 편집 효율을 검출하였다 (도 6a). 엑손 51의 스플라이스 수용자 부위를 표적화할 수 있는 3개의 가이드 RNA (Ex51-g1, Ex51-g2, 및 Ex51-g3)의 능력이 표 5 및 도 2b에 제시되어 있다. GFP-양성 분류된 293 세포에서, Ex51-g3은 높은 편집 활성을 보인 반면, Ex51-g1 및 Ex51-g2에서는 활성이 검출불가능하였다. 이어서, 엑손 51, 45, 53, 44, 46, 52, 50, 43, 6, 7, 8, 및 55를 포함하는, 상위 12개의 엑손을 표적화하는 가이드 RNA의 절단 효율을 평가하였다. 각 엑손의 최고 편집 효율과 함께,1 또는 2개의 가이드 RNA가 도 1c에 제시되어 있다. 엑손 51, 45, 및 55에 대해 선택된 가이드 RNA는 PAM으로서 NAG를 사용한다 (표 5). 근편집된 상위 12개의 엑손으로부터의 게놈 중합효소 연쇄 반응 (PCR) 생성물을 클로닝하고, 서열분석하였다 (도 5a 및 표 20). 필수 스플라이스 부위를 제거하거나, 또는 오픈 리딩 프레임을 이동시킨 삽입/결실(Indel)이 관찰되었다 (도 5a). 뇌 및 신장 조직에서, N 말단이 말단절단된 형태의 디스트로핀 (Dp140)은 인트론 44에서 대안적 프로모터로부터 전사된다. 293 세포에서 역전사 PCR (RT-PCR) 생성물의 서열분석에 의해 Dp140 mRNA에서 6개의 표적화된 엑손 (엑손 51, 53, 46, 52, 50, 및 55)의 스키핑을 확인하였다 (도 5b).
Figure pct00096
근편집에 의한 다양한 DMD 환자 돌연변이의 교정
엑손 스키핑에 의해 상이한 유형의 인간 DMD 돌연변이를 교정할 수 있는 단일-가이드 RNA의 효과를 평가하기 위해, 대표적인 DMD 돌연변이 유형: 큰 결실 (Del로 명명; 엑손 48 내지 50 결여), 슈도-엑손 돌연변이 (pEx로 명명; 인트론 점 돌연변이에 의해 유발), 및 중복 돌연변이 (Dup로 명명)를 갖는 3개의 DMD iPSC 세포주를 수득하였다. 간략하면, 전혈로부터 수득된 말초 혈액 단핵 세포 (PBMc)를 배양한 후, 리프로그래밍 인자를 발현하는 재조합 센다이(Sendai) 바이러스 벡터를 이용하여 iPSC로 리프로그래밍하였다. 세포주에 엑손 48의 큰 결실을 갖는 DMD 환자로부터의 iPSC 세포주 (Del로도 공지) 상의 iPSC 근편집에서의 돌연변이를 교정 또는 우회하기 위한 Cas9 및 가이드 RNA를 뉴클레오펙션에 의해 세포에 도입하였다. 이어서, 처리된 세포 풀 또는 단일 클론을 표준화된 조건을 이용하여 유도 심근세포 (iCM)로 분화시켰다. 정제된 iCM을 사용하여 3D-EHM을 생성하고, 기능성 검정법을 수행하였다 (도 2a).
큰 결실돌연변이의 교정
DMD 사례 중 ~60 내지 70%는 하나 이상의 엑손의 큰 결실에 의해 유발되는 것으로 추정된다. 핫스팟 중 엑손 48 내지 50의 큰 결실을 갖는 DMD 환자로부터의 iPSC 세포주에서 근편집을 수행하였다. 도 2b에 제시된 바와 같이, 큰 결실은 프레임시프트 돌연변이를 생성하고, 엑손 51에 조기성숙 정지 코돈을 도입한다. 엑손 51에서 스플라이스 수용자의 파괴는 원칙적으로 엑손 47 내지 52의 스플라이싱을 허용하여 오픈 리딩 프레임을 재구성할 것이다 (도 2b 및 도 6b). 이론상, 스키핑 엑손 51은 잠재적으로는 DMD 환자의 ~13%를 교정할 수 있다. 최적화된 가이드 RNA Ex51-g3 및 Cas9 (도 2c)를 상기 iPSC 세포주 내로 뉴클레오펙션시킴으로써, 게놈 서열분석에 의해 입증되는 바와 같이, 성공적으로 스플라이스 수용자를 파괴시키거나, NHEJ에 의해 엑손 51의 리프레이밍을 일으키고, 오픈 리딩 프레임을 회복시켰다 (도 6b). 근편집 및 DMD iPSC (Del-Cor.) 풀을 iCM으로 분화시키고, 엑손 47 내지 52 증폭으로부터의 RT-PCR 생성물을 서열분석함으로써 프레임내 디스트로핀 mRNA 발현 구제를 확인하였다 (도 2d 및 도 6c).
슈도 -엑손 돌연변이 교정
본 접근법을 희귀 돌연변이로 추가로 확장시키기 위해, 인트론 47에 자발적 점 돌연변이 (c.6913 - 4037T>G)를 갖는 DMD 환자로부터의 iPSC (pEx로도 공지) 내의 점 돌연변이를 교정하는 시도를 수행하였다. 상기 점 돌연변이는 신규한 RNA 스플라이싱 수용자 부위 (YnNYAG)를 생성하여 그 결과로, 조기성숙 정지 신호를 코딩하는 엑손 47A의 슈도-엑손을 생성한다 (도 2e). 돌연변이를 정확하게 표적화하는 2개의 가이드 RNA (Ex47A-g1 및 Ex47A-g2)를 디자인하였다 (도 2f 및 도 7a 및 7b). 도 2g에 제시된 바와 같이, 근편집은 잠재적 스플라이스 수용자 부위를 폐기하였고, 슈도-엑손을 영구적으로 스키핑하여 교정된 세포 (pEx-Cor.)에서 전장의 디스트로핀 단백질을 회복시켰다. 엑손 스키핑의 효율을 상기 DMD iCM에서 RT-PCR에 의해 시험하였다 (도 2g). RT-PCR 생성물의 서열분석 결과, 엑손 47이 엑손 48로 스플라이싱된 것으로 확인되었다 (도 7c).
야생형 인트론에는 SpCas9에 대한 PAM 서열 (NAG)이 결여되어 있는 바, Ex47A-g2는 오직 돌연변이체 대립유전자만을 표적화한다는 것은 주목할 만하다. 또한, 상기 환자에서 T > G 돌연변이는 Cas9에 대한 질환-특이적 PAM 서열 (AG)을 생성한다. 이러한 유형의 교정은 어떤 내부 결실도 없이 정상 디스트로핀 단백질을 회복한다는 것 또한 주목할 만하다 (도 7b 및 7c).
큰 중복 돌연변이의 교정
엑손 중복은 확인된 DMD 유발 돌연변이 중 ~10 내지 15%를 차지한다. 큰 중복 (엑손 55 내지 59)을 갖는 DMD 환자로부터의 iPSC 세포주 (Dup로도 공지)에서 디스트로핀 오픈 리딩 프레임을 파괴하는 근편집을 시험하였다 (도 2h). 상기 환자로부터의 세포에서 전체 게놈 서열분석 및 카피수 변동 프로파일 분석을 수행하고, 인트론 54 중의 정확한 삽입 부위를 확인하였다 (도 2h). PCR에 의해 상기 삽입 부위 (In59-In54 연접부)를 확인하였다 (도 8a 및 표 4).
중복된 엑손 55의 5' 측면에 위치하는 서열은 동일한 바, 상기 영역을 표적화하는 한 가이드 RNA는 2개의 DSB를 생성하고, 전제 중복된 영역 (엑손 55 내지 59; ~150 kb))를 결실시킬 수 있어야 한다고 가정하였다. 이러한 가설을 시섬하기 위해, 인트론 54 및 엑손 55의 연접부 인근의 서열을 표적화하는 3개의 가이드 RNA (In54-g1, In54-g2, 및 In54-g3)를 디자인하였다 (도 2i). 가이드 RNA를 이용한 DNA 절단 효율을 293 세포에서 T7E1에 의해 평가하였다 (도 8b). Dup iPSC에서의 후속 실험을 위해 가이드 RNA In54-g1을 선택하였다. 근편집된 Dup iPSC 혼합물로부터의 게놈 PCR 생성물을 클로닝하고, 서열분석하였다 (도 8c).
중복 돌연변이의 교정을 확인하기 위해, 처리된 DMD iPSC (Dup-Cor.로도 공지) 풀을 심근세포로 분화시켰다. 중복-특이적 프라이머 (Ex59F, 엑손 59에서 정방향 프라이머, 및 Ex55R, 엑손 55에서 역방향 프라이머)를 이용하여 RT-PCR에 의해 중복된 엑손을 갖는 mRNA를 반정량화하고, b-액틴 유전자의 발현으로 정규화하였다 (도 2j 및 표 4). 예상대로, 중복-특이적 RT-PCR 밴드는 야생형 (WT) 세포에는 존재하지 않았고, Dup-Cor. 세포에서는 급격히 감소되었다. 이러한 결과를 확인하기 위해, 엑손 53에서 Ex55 및 Ex59에서 엑손 60의 중복 경계에서의 RT-PCR을 수행하였다 (도 8d). 교정된 iCM에서 중복-특이적 상단 밴드의 강도는 감소되었다. 처리된 세포 혼합물로부터 단일 콜로니를 취하였다. 중복-특이적 PCR 프라이머 (F2-R1)를 사용하여 교정된 콜로니를 스크리닝하였다 (도 8e). 3개의 대표적인 교정된 콜로니 (Dup-Cor. #4, #6, 및 #26) 및 비교정된 대조군 (Dup)의 PCR 결과는 도 8e에 제시되어 있다. 콜로니 4, 6, 및 26에서의 중복-특이적 PCR 밴드 부재를 통해 중복된 DNA 영역의 결실을 확인할 수 있었다.
근편집에 의한 환자 유래된 iCM에서의 디스트로핀 단백질 회복
이어서, 면역세포화학법 (도 3a 내지 3c, 및 도 6d, 7d, 및 8f) 및 웨스턴 블롯 분석 (도 24, d 내지 f)에 의해 단일 클론 및 처리된 iCM 풀에서 디스트로핀 단백질의 회복 및 안정적인 발현을 확인하였다. 심지어 클론 선별 및 확장을 수행하지 않고도, Del-Cor., pEx-Cor., 및 Dup-Cor.의 대부분의 iCM은 디스트로핀 양성이었다 (도 3a 내지 3C, 및 도 6d, 7d, 및 8f). 근편집된 Del iPSC 혼합물로부터, 2개의 클론 (#16 및 #27)을 취하고, 심근세포로 분화시켰다. 디스트로핀 발현 수준이 더 높은 클론 #27을 후속 실험을 위해 선택하였다 (Del-Cor-Sc로도 공지). 교정된 pEx에 대해 선택된 한 클론 (#19)은 추가 연구를 위해 사용하였다 (pEx-Cor-Sc로도 공지). 교정된 Dup에 대해 선택된 2개의 클론 (#26 및 #6)을 iCM으로 분화시켰다. 클론 #6은 기능성 검정법 실험에서 사용하였다 (Dup-Cor-Sc로도 공지). 면역세포화학법 및 웨스턴 블롯 분석에 의하면, 교정된 iCM의 디스트로핀 단백질 발현 수준은 WT 심근세포와 유사한 것으로 추정되었다 (50 내지 100%) (도 3).
근편집에 의한 환자 유래된 iCM의 기능 회복
생화학적 방법에 의해 디스트로핀 mRNA 및 단백질 발현을 측정하는 것 이외에도, 정상, DMD, 및 교정된 DMD iCM으로부터 유래된 3D-EHM을 이용하여 대규모로 기능 분석을 사용하였다. 간략하면, iPSC 유래 심근세포를 글루코스 결핍에 의해 대사적으로 정제하였다. 정제된 심근세포를 인간 포피 섬유모세포 (HFF)와 함께 70%:30% 비율로 혼합하였다. 세포 혼합물을 소 콜라겐 및 무혈청 배지의 혼합물 중에서 재구성하였다. 배양 4주 후, 수축 실험을 수행하였다 (도 4a).
8개의 iPSC 세포주로부터의 EHM을 시험하였다: (i) WT, (ii) 비교정된 Del, (iii) Del-Cor-SC, (iv) 비교정된 pEx, (v) pEx-Cor., (vi) pEx-Cor-SC, (vii) 비교정된 Dup, 및 (viii) Dup-Cor-SC. EHM에서 DMD 및 교정된 DMD 심근세포의 기능적 표현형 분석 결과, WT EHM과 비교하여 DMD EHM 모두(Del, pEx, 및 Dup)에거 수축성 기능 장애가 나타났다 (도 4b 내지 4e). pEx 및 Dup EHM과 비교하여 Del에서 더욱 뚜렷한 수축성 기능 장애가 관찰되었다. 수축 장력 (FOC)은 DMD EHM에서 현저히 감소되었고, 교정된 DMD EHM (Del-Cor-SC, pEx-Cor-SC, 및 Dup-Cor-Sc)에서 유의적으로 개선되었고 (도 4b 내지 4e), 여기서, Dup-Cor-SC에서는 심근세포 최대 수축 촉진 능력이 완전히 회복되었다 (도 4d 및 4e).
현행 유전자 요법 전달 방법은 오직 심장 근육의 일부분에만 영향을 줄 수 있기 때문에, 분명한 질문은 DCM의 표현형을 구제하기 위해서는 어느 정도 비율(%)의 교정된 심근세포가 요구되는지에 관한 것이다. 상기 질문을 해결하기 위해, DMD 세포 (Del) 및 교정된 DMD 세포 (Del-Cor-Sc)를 정밀 혼합하여 EHM에서의 광범위한 "치료 효능" (10 내지 100%)을 모의하였다 (도 4f). 이 결과, 수축성 표현형의 부분적 (30%) 또는 최대 (50%) 구제를 위해서는 30 내지 50%의 심근세포가 수복되어야 하는 것으로 밝혀졌다 (도 4f). 상기 관찰결과는, 보유자 마우스에서 50% 심근세포에서의 모자이크 디스트로핀 발현은 거의 정상적인 심장 표현형에 이르게 된 것을 보여준 이전의 생체내 연구와 일치한다. 본 발명자들의 관찰결과는 교정된 DMD EHM에서 수축성 기능 장애는 WT EHM의 비교가능한 수준으로 효율적으로 회복되었다는 것을 보여준다. 따라서, 근편집은 EHM에서 DMD의 임상적 표현형을 구제할 수 있는 고도로 특이적이고, 효율적인 접근법이다.
고찰
DMD 유전자는 260만 개의 염기쌍을 포함하고, 79개의 엑손을 코딩하는, 인간 게놈에서 가장 큰 것으로 알려진 유전자이다. DMD 유전자의 큰 크기와 복잡한 구조는 그의 자발적 돌연변이의 비율이 높은 것의 원인이 된다. 인간에서는 ~3,000여 개의 돌연변이가 문서로 기록되어 있으며, 이는 큰 결실 또는 중복 (~77%), 작은 삽입/결실(indel) (~12%), 및 점 돌연변이 (~9%)를 포함한다. 이들 돌연변이는 주로 엑손에 영향을 주지만; 인트론 돌연변이는 본원에서 pEx 돌연변이에 대해 제시된 바와 같이, 스플라이싱 패턴을 변경시키 질환을 유발할 수 있다.
CRISPR/Cas9 유전자 편집에 의한 다양한 DMD 돌연변이의 교정을 잠재적으로 간소화시키기 위해, DMD 환자의 ~60%를 차지하는 상위 12개의 엑손을 스키핑할 수 있는 가이드 RNA를 확인하였다. 따라서, 각 DMD 돌연변이에 대한 개별 가이드를 디자인하거나, 또는 가이드 RNA 쌍을 이용하여 큰 게놈 영역을 절단할 필요가 없다.
오히려, 개별 엑손의 스키핑이 다수의 환자에서 디스트로핀 발현을 회복시킬 수 있도록 환자 돌연변이를 군으로 분류할 수 있다. 실시예 1에 기술된 개념 증명 연구에서, 단 하나의 가이드 RNA만을 이용하는 최적화된 근편집 접근법이, 큰 결실, 점 돌연변이, 및 중복을 비롯한, DMD 집단 대부분을 커버하는, 광범위한 돌연변이 유형에서 DMD 오픈 리딩 프레임을 효율적으로 회복시켰다. 심지어 비교적 크고, 복잡한 결실도, 다중의 가이드 RNA가 DNA 말단의 라이게이션과 함께 원위 부위에서의 자발적 절단을 유도하도록 요구하지 않으면서, DNA 서열에서, 스플라이스 수용자 또는 공여자 부위를 제거하는 단일 절단에 의해 교정될 수 있다. 엑손-스키핑은 대개는 DMD를 좀더 경미한 BMD로 전환시키지만, 중복 또는 슈도-엑손 돌연변이를 갖는 환자의 서브세트의 경우, 본 발명자들이 pEx 및 Dup 돌연변이에 대한 본 연구에서 밝힌 바와 같이, 근편집은 돌연변이를 제거할 수 있고, 정상적인 디스트로핀 단백질의 생산을 회복시킬 수 있다.
수축성 기능 장애 및 심실 확장을 특징으로 하는 확장성 심근증은 DMD 환자 사망의 주 원인 중 하나이다. 그러나, 심장 생리학적 성질 및 해부삭적 구조상의 종간 차이가 현저하다는 이유 뿐만 아니라, 질환의 자연사, 이들 동물의 수명 단축 (~2년), 및 그의 심장의 작은 크기 (인간 심장 크기의 1/3,000) 때문에, 심근증은 어린 DMD 마우스 모델에서는 일반적으로 관찰되지 않는다. 2D 세포 배양 시스템 및 작은 동물 모델의 한계 및 단점을 극복하기 위해, 인간 iPSC-유래 3D-EHM을 사용하여 디스트로핀 돌연변이가 심수축성, 및 칼슘 농도에 대한 감수성을 손상시켰다는 것을 보여주었다. DMD 환자의 DCM 임상적 표현형과 유사한 DMD EHM에서 수축성 기능 장애가 관찰되었다. 수축성 기능 장애는 교정된 DMD EHM에서 근편집에 의해 부분적으로 내지 완전히 회복되었다. 따라서, 유전자 편집은 유전적 원인을 제거하고, DMD와 연관된 근육 및 심장 이상을 교정하는 효과적인 수단을 나타낸다. 본원에서 제공된 데이터는 EHM가 근편집의 치료적 효능의 근사값을 구하는 데 적합한 임상전 도구로서의 역할을 한다는 것을 추가로 입증한다.
인간 CRISPR 임상 시험은 중국 및 미국에서 승인을 받았다. 오프-타겟 효과가 게놈에서 예상 밖의 돌연변이를 유발할 수 있기 때문에, CRISPR/Cas9 시스템에 대한 한가지 중요한 관심사는 특이성이다. 가능한 오프-타겟 효과를 평가하기 위하여, (i) 표적 부위의 인실리코 예측 및 심층 서열분석에 의한 상기 표적 부위 시험, 및 (ii) 비편향 전체 게놈 서열분석을 비롯한, 다중의 접근법이 개발되어 왔다. 추가로, Cas9 및 가이드 RNA의 투여량 적정, 쌍형성한 Cas9 니카제, 말단절단된 가이드 RNA, 및 고충실도 또는 증강된 Cas9를 비롯한, 수개의 새로운 접근법이 잠재적인 오프-타겟 효과를 최소화하고/거나, CRISPR/Cas9 시스템의 특이성을 개선시키는 것으로 보고되었다. 비록 대부분의 연구가 시험관내 세포 배양 시스템을 사용하였지만, 본 발명자들 및 다른 연구원들은 마우스에서의 생식세포계열 편집 및 출생 후 편집에 관한 본 발명자들의 연구에서 오프-타겟 효과를 관찰하지 못하였다. 인간 착상전 배아에서의 유전자 편집에 관한 최근 연구에 따르면, 오프-타겟 돌연변이 또한 편집된 게놈에서는 검출되지 않았다. 비록 오프-타겟 효과에 관하나 종합적이고, 포괄적인 분석이 본 연구의 범주 그 이상이 되겠지만, 결국에는 잠재적 치료 적용 이전에 개별 가이드 RNA의 가능한 오프-타겟 효과를 철저히 평가하는 것이 중요할 것이라는 것을 본 발명자들은 알고 있다.
물질 및 방법
플라스미드. 2A-EGFP 및 가이드 RNA의 백본과 함께 인간 코돈 최적화된 SpCas9 유전자를 함유하는 pSpCas9(Bb)-2A-GFP (PX458) 플라스미드는 F. 장(F. Zhang)으로부터 기증받은 것이다 (플라스미드 #48138, 애드진(Addgene)). 펭 장 랩(Feng Zhang Lab) CRISPR 플라스미드 설명서 (addgene.org/crispr/zhang/)에 따라 가이드 RNA의 클로닝을 수행하였다.
인간 293 세포의 형질감염 및 세포 분류. 세포를 제조사의 설명서에 따라 리포펙타민 2000 형질감염 시약 (써모 피셔 사이언티픽)에 의해 형질감염시키고, 세포를 총 48 내지 72시간 동안 인큐베이션시켰다. 텍사스 대학교(University of Texas: UT) 사우쓰웨스턴 메디컬 센터(Southwestern Medical Center)의 유세포 분석 코어 시설(Flow Cytometry Core Facility)에 의해 세포 분류를 수행하였다. 형질감염된 세포를 트립신-EDTA 용액을 이용하여 해리시켰다. 혼합물을 37℃에서 5 min 동안 인큐베이션시키고, 10% 우태아 혈청으로 보충된, 2 ml의 가온 둘베코스 변형 이글 배지를 첨가하였다. 재현탁된 세포를 15 ml 팔콘(Falcon) 튜브로 옮기고, 20회에 걸쳐 부드럽게 연마시켰다. 세포를 실온에서 5 min 동안 1,300 rpm으로 원심분리하였다. 배지를 제거하고, 세포를 2% 소 혈청 알부민 (BSA)으로 보충된, 500 ml의 포스페이트 완충처리된 염수 (PBS) 중에 재현탁시켰다. 세포를 세포 스트레이너 튜브 안으로 그의 메쉬 캡을 통해 여과하였다. 분류된 단일 세포를 GFP+ 및 GFP-세포 집단으로 소형원심분리기 튜브 내로 분리하였다.
인간 iPSC 유지, 뉴클레오펙션 , 및 분화. DMD iPSC 세포주 Del을 셀 뱅크 RIKEN 바이오리소스 센터(Cell Bank RIKEN BioResource Center) (세포 번호 HPS0164)로부터 구입하였다. WT iPSC 세포주는 D. 개리(D. Garry) (미네소타 대학교(University of Minnesota))로부터 기증받은 것이었다. 다른 iPSC 세포주 (pEx 및 Dup)는 UT 사우쓰웨스턴 웰스톤 미오에디팅 코어(UT Southwestern Wellstone Myoediting Core)에 의해 생성하고, 유지시켰다. 간략하면, DMD 환자의 전혈로부터 수득한 PBMC를 배양한 후, 이어서, 리프로그래밍 인자 (시토튠 2.0(Cytotune 2.0), 라이프 테크놀러지즈(Life Technologies))를 발현하는 재조합 센다이 바이러스 벡터를 이용하여 iPSC로 리프로그래밍하였다. 면역세포화학법, 마이코플라스마 검사, 및 기형종 형성에 의해 iPSC 콜로니를 확인하였다. 인간 iPSC를 mTeSRTM1 배지 (STEMCELL 테크놀러지즈(STEMCELL Technologies))에서 배양하고, 대략 매 4일마다 계대접종하였다 (분할비 1:18). 뉴클레오펙션 1시간 전, iPSC를 10 mM ROCK 억제제 (Y-27632)로 처리하고, 어큐타제(Accutase) (이노베이티브 셀 테크놀러지즈 인크.(Innovative Cell Technologies Inc.))를 이용하여 단일 세포로 해리시켰다. 세포 (1 Х 106)를 5 mg의 SpCas9-2A-GFP 플라스미드와 혼합하고, 제조사의 프로토콜에 따라 P3 프라이머리 셀 4D-뉴클레오펙터 X(P3 Primary Cell 4D-Nucleofector X) 키트 (론자(Lonza))를 사용하여 뉴클레오펙션시켰다. 뉴클레오펙션 후, iPSC를 10 mM ROCK 억제제, 페니실린-스트렙토마이신 (1:100) (써모 피셔 사이언티픽), 및 프리모신 (100 mg/ml; 인비보겐(InvivoGen))으로 보충된 mTeSRTM1 배지 중에서 배양하였다. 뉴클레오펙션 후 3일째, 상기 기술된 바와 같이, 형광 활성화 세포 분류에 의해 GFP+ 및 GFP-를 분류하고, PCR 및 T7E1 검정법을 수행하였다.
분류된 세포로부터의 게놈 DNA 단리. 프로테아제 K (20 mg/ml)를 최종 농도 1 mg/ml가 될 때까지 디렉트PCR 용해 시약(DirectPCR Lysis Reagent) (비아겐 바이오테크. 인크.(Viagen Biotech Inc.))에 첨가하였다. 세포를 4℃에서 10 min 동안 6,000 rpm으로 원심분리하고, 상청액을 폐기하였다. 얼음 상에 유지시킨 세포 펠릿을 50 내지 100 ml의 디렉트PCR/프로테아제 K 용액에 재현탁시키고, 55℃에서 >2시간 동안, 또는 클럼프가 관찰되지 않을 때까지, 인큐베이션시켰다. 조 용해물을 85℃에서 30 min 동안 인큐베이션시킨 후, 10 s 동안 회전시켰다. NaCl을 최종 농도가 250 mM가 될 때까지 첨가한 후, 0.7 부피의 이소프로판올을 첨가하여 DNA를 침전시켰다. DNA를 4℃에서 5 min 동안 13,000 rpm으로 원심분리하고, 상청액을 폐기하였다. DNA 펠릿을 1 ml의 70% EtOH로 세척하고, 물에 용해시켰다. 나노드롭(NanoDrop) 장치 (써모 피셔 사이언티픽)를 이용하여 DNA 농도를 측정하였다.
PCR에 의한, 표적화된 게놈 영역 증폭. PCR 검정법은 2 ml의 GoTaq 폴리머라제 (Promega), 20 ml의 5Х 그린 GoTaq 반응 완충제, 8 ml의 25 mM MgCl2, 2 ml의 10 mM 프라이머, 2 ml의 10 mM 데옥시뉴클레오티드 트리포스페이트, 8 ml의 게놈 DNA, 및 100 ml가 되도록 하는 양으로 이중 증류 H2O (ddH2O)를 함유하였다. PCR 조건은 하기와 같았다: 94℃에서 2 min 동안, 32Х (94℃에서 15 s 동안, 59℃에서 30 s 동안, 및 72℃에서 1 min 동안), 72℃에서 7 min 동안, 및 이어서, 4℃에서 유지. 2% 아가로스 겔 전기영동에 의해 PCR 생성물을 분석하고, 직접 서열분석하기 위해 QIA퀵 PCR 정제(QIAquick PCR Purification) 키트 (퀴아젠(Qiagen)를 이용하여 겔로부터 정제하였다. 이들 PCR 생성물을 제조사의 설명서에 따라 pCRII-TOPO 벡터 (인비트로겐(Invitrogen))로 서브클로닝하였다. 개별 클론을 취하여 DNA 서열분석을 수행하였다.
PCR 생성물의 T7E1 분석. 하기 조건을 이용하여 25 ml의 게놈 PCR 샘플의 변성/복원에 의해 미스매칭된 이중체 DNA를 수득하였다: 95℃에서 10 min 동안, 95℃에서 85℃로 (-2.0℃/s), 85℃에서 75℃로 (-0.3℃/s), 75℃에서 1 min 동안, 75℃에서 65℃로 (-0.3℃/s), 65℃에서 1 min 동안, 65℃에서 55℃로 (-0.3℃/s), 55℃에서 1 min 동안, 55℃에서 45℃로 (-0.3℃/s), 45℃에서 1 min 동안, 45℃에서 35℃로 (-0.3℃/s), 35℃에서 1 min 동안, 35℃에서 25℃로 (-0.3℃/s), 25℃에서 1 min 동안, 및 이어서, 4℃에서 유지.
변성/재생 후, 샘플에 하기를 첨가하였다: 3 ml의 10Х NEBuffer 2, 0.3 ml의 T7E1 (뉴 잉글랜드 바이오랩스(New England Biolabs)), 및 30 ml가 될 때까지 ddH2O. 분해된 반응물을 37℃에서 1시간 동안 인큐베이션시켰다. 비분해된 PCR 샘플 및 T7E1-분해된 PCR 생성물을 2% 아가로스 겔 전기영동에 의해 분석하였다.
전체 게놈 서열분석. 혈액 샘플을 노보겐 코포레이션(Novogene Corporation)에 제출하여 전체 게놈 서열분석을 수행하였다. 정제된 게놈 DNA (1.0 mg)를 DNA 샘플 제조를 위한 입력 물질로서 사용하였다. 제조사의 설명서에 따라 TruSeq 나노 DNA HT 샘플 제조(TruSeq Nano DNA HT Sample Preparation) 키트 (일루미나(Illumina))를 이용하여 서열분석 라이브러리를 생성하였다. 간략하면, DNA 샘플을 초음파 처리하여 350 bp 크기로 단편화하였다. DNA 단편을 말단 폴리싱하고, A-테일형성하고, 추후 PCR 증폭과 함께 알루미나를 위해 전장의 어댑터와 라이게이션시켰다. 일루미나 서열분석 플랫폼에서 라이브러리를 서열분석하고, 쌍형성 말단 리드를 생성하였다.
RNA 단리. RNA를 제조사의 설명서에 따라 TRIzol RNA 단리 시약 (써모 피셔 사이언티픽)을 이용하여 세포로부터 단리시켰다.
심근세포 분화 및 정제. iPSC를 PBS로 코팅된 플레이트 중 1:120 마트리겔(Matrigel) 상에서 TESR-E8 (STEMCELL 테크놀러지즈(STEMCELL Technologies))에서 적합화시키고, 유지시키고, 주 2회에 걸쳐 EDTA 용액 (베르센(Versene), 써모 피셔 사이언티픽)을 이용하여 계대접종하였다. 심장 분화를 위해, iPSC를 5 Х 104 내지 1 Х 105 세포/㎠로 플레이팅하고, 3일 동안 RPMI, 2% B27, 200 mM L-아스코르브산-2-포스페이트 세스퀴마그네슘 염 수화물 (Asc; 시그마-알드리치(Sigma-Aldrich)), 액티빈 A (9 ng/ml; R&D 시스템즈(R&D Systems))), BMP4 (5 ng/ml; R&D 시스템즈), 1 mM CHIR99021 (스템젠트(Stemgent)), 및 FGF-2 (5 ng/ml; 밀테니이 바이오테크(Miltenyi Biotec))로 유도하고; RPMI 배지로 추가로 세척한 후, 세포를 2% B27 및 200 mM Asc로 보충된 RPMI 중에서 4일째부터 13일째까지 배양하였다. 2.2 mM 소듐 락테이트 (시그마-알드리치), 100 mM b-메르캅토에탄올 (시그마-알드리치), 페니실린 (100 U/ml), 및 스트렙토마이신 (100 mg/ml)을 포함하는 글루코스-무함유 RPMI (써모 피셔 사이언티픽) 중에서 13일째부터 17일째까지 글루코스 결핍에 의해 심근세포를 대사적으로 정제하였다. 심근세포 순도는 15호의 독립 분화 실행으로부터 92 ± 2%였다 (각 세포주당 1 내지 3회).
EHM 생성. 정의된, 무혈청 EHM을 생성하기 위해, 정제된 심근세포를 HFF (아메리칸 타입 컬쳐 콜렉션(American Type Culture Collection))와 70%:30% 비율로 혼합하였다. 세포 혼합물을 pH 중화된 의약 등급의 소 콜라겐 (EHM다 0.4 mg; LLC 콜라겐 용액) 및 농축된 무혈청 배지 [2Х RPMI, 인슐린 무함유 8% B27, 페니실린 (200 U/ml), 및 스트렙토마이신 (200 mg/ml)]의 혼합물 중에서 재구성하고, 인슐린 무함유 4% B27, 1% 비필수 아미노산, 2 mM 글루타민, 300 mM 아스코르브산, IGF1 (100 ng/ml; AF-100-11), FGF-2 (10 ng/ml; AF-100-18b), VEGF165 (5 ng/ml; AF-100-20), TGF-b1 (5 ng/ml; AF-100-21C; 성장 인자 모두 페프로테크(PeproTech)로부터 입수), 페니실린 (100 U/ml), 및 스트렙토마이신 (100 mg/ml)을 포함하는 이스코브(Iscove) 배지 중에서 3일 동안 배양하였다. 3일 동안의 응축 기간 후, EHM을 가요성 홀더로 옮겨 증장력성 수축을 지지하였다. 총 4주 동안의 EHM 배양 기간 후 분석을 수행하였다.
수축성 기능 분석. 가스화된 (5% CO2/95% O2) 티로드 용액(Tyrode's solution) (120 mM NaCl, 1 mM MgCl2, 0.2 mM CaCl2, 5.4 mM KCl, 22.6 mM NaHCO3, 4.2 mM NaH2PO4, 5.6 mM 글루코스, 및 0.56 mM 아스코르베이트 함유) 중 37℃ 기관 배쓰에서 정적 수축 조건하에 수축 실험을 수행하였다. EHM을 200 mA의 5 ms2 펄스로 1.5 Hz로 전기적으로 자극시켰다. 프랭크 스탈링(Frank-Starling) 법칙에 따라 최대 이완기 장력 진폭 (FOC)을 관찰할 때까지 125 mm 간격으로 EHM을 기계적으로 신장시켰다. 최대 수축 촉진 능력을 측정하여 세포외 칼슘 증가 (0.2 mM에서 4 mM)에 대한 반응을 조사하였다. 명시되는 경우, 장력을 근육 함량 (근육 원섬유절 a-액티닌-양성 세포 함량, 유세포 분석으로 측정)으로 정규화하였다.
EHM -유래 세포의 유세포 분석법. EHM의 단일 세포 현탁액을 앞서 기술된 바와 같이 제조하고, 70% 빙냉 에탄올 중에서 고정시켰다. 고정된 세포를 훽스트 3342 (10 mg/ml; 라이프 테크놀러지즈)로 염색하여 세포 더블릿를 배제시켰다. 근육 원섬유절 a-액티닌 염색 (클론 EA-53, 시그마-알드리치)에 의해 심근세포를 확인하였다. LSRII SORP 세포측정기 (BD 바이오사이언시스(BD Biosciences))에서 세포를 계측하고, DIVA 소프트웨어를 사용하여 분석하였다. 샘플당 적어도 10,000개의 이벤트가 분석되었다.
면역염색. iPSC-유래 심근세포를 아세톤으로 고정시키고, 면역염색시켰다. 고정된 심근세포를 혈청 칵테일 (2% 정상적인 말 혈청/2% 정상적인 당나귀 혈청/0.2% BSA/PBS)로 차단하고, 0.2% BSA/PBS 중에서 디스트로핀 항체 (1:800; MANDYS8, 시그마-알드리치) 및 트로포닌-I 항체 (1:200; H170, 산타 크루즈 바이오테크놀러지(Santa Cruz Biotechnology))와 함께 인큐베이션시켰다. 4℃에서 밤새도록 인큐베이션시킨 후, 2차 항체 [비오티닐화된 말 항-마우스 면역글로불린 G (IgG) (1:200; 벡터 라보라토리즈(Vector Laboratories)) 및 플루오레세인-접합된 당나귀 항-토끼 IgG (1:50; 잭슨 이뮤노리서치(Jackson ImmunoResearch))]와 함께 1시간 동안 인큐베이션시켰다. 훽스트 33342 (몰레큘러 프로브즈(Molecular Probes))를 이용하여 핵을 대조 염색하였다.
면역염색하고자 하는 EHM 냉동절편을 해동시키고, 추가로 대기 건조시키고, 냉 아세톤에서 고정시켰다 (-20℃에서 10 min 동안). 절편을 PBS (pH 7.3) 중에서 잠깐 평형화시킨 후, 혈청 칵테일 (2% 정상적인 말 혈청/2% 정상적인 당나귀 혈청/0.2% BSA/ PBS)로 1시간 동안 차단시켰다. 차단 칵테일을 경사분리하고, 중간에 세척하지 않고, 0.2% BSA/PBS 중 디스트로핀/트로포닌 1차 항체 칵테일 [마우스 항-디스트로핀, MANDYS8 (1:800; 시그마-알드리치) 및 토끼 항-트로포닌-I (1:200; H170, 산타 크루즈 바이오테크놀러지)]을 적용시켰다. 4℃에서 밤새도록 인큐베이션시킨 후, PBS로 세척하여 비결합 1차 항체를 제거하고, 절편을 0.2% BSA/PBS 중에 희석된 2차 항체 [비오티닐화된 말 항-마우스 IgG (1:200; 벡터 라보라토리즈) 및 로다민 당나귀 항-토끼 IgG (1:50; 잭슨 이뮤노리서치)]로 1시간 동안 프로빙하였다. PBS로 세척하여 비결합 2차 항체를 제거하고, 절편을 PBS 중에 희석된 플루오레세인-아비딘-DCS (1:60; 벡터 라보라토리즈)와 함께 10 min 동안 인큐베이션시켜 최종 디스트로핀 표지화를 수행하였다. PBS로 세척하여 비결합 로다민을 제거하고, 훽스트 33342 (몰레큘러 프로브즈)를 이용하여 핵을 대조 염색하고, 슬라이드를 벡타쉴드(Vectashield) (벡터 라보라토리즈)를 이용하여 커버슬립으로 커버하였다.
웨스턴 블롯 분석. 디스트로핀에 대한 항체 (ab15277, 압캠(Abcam); D8168, 시그마-알드리치), 글리세르알데히드-3-포스페이트 데히드로게나제 (MAB374, 밀리포어(Millipore)), 및 심장 미오신 중쇄 (ab50967, 압캠)를 이용하여 인간 iPSC-유래 심근세포에 대한 웨스턴 블롯 분석을 수행하였다. 기술된 실험을 위해 염소 항-마우스 및 염소 항-토끼 호스래디쉬 퍼옥시다제-접합된 2차 항체 (바이오-래드(Bio-Rad))를 이용하였다.
* * * * * * * * * * * * *
본원에 개시되고, 청구된 조성물 및/또는 방법 모두 본 개시내용에 비추어 과도한 실험 없이 이루어지고, 실행될 수 있다. 본 개시내용의 조성물 및 방법이 바람직한 실시양태의 측면에서 기술되었지만, 본 개시내용의 개념, 정신 및 범주로부터 벗어남이 없이, 변형이 본원에 기술된 조성물 및/또는 방법 및 방법의 단계 또는 단계의 순서에 적용될 수 있음이 당업자에게 명백할 것이다. 더욱 구체적으로, 화학적으로 및 생리학적으로 둘 모두 관련된 특정 작용제가 본원에 기술된 작용제를 대체할 수 있지만, 동일하거나 유사한 결과가 달성될 수 있음이 명백할 것이다. 당업자에게 명백한 상기와 같은 모든 유사한 치환 및 변형은 첨부된 청구범위에 정의된 바와 같은 본 개시내용의 정신, 범주 및 개념 내에 포함되는 것으로 간주된다.
VIII. 참고문헌
하기 참고문헌은 본원에 기재된 것을 보충하는 예시적인 방법 또는 다른 세부사항을 제공하는 정도로, 본원에서 구체적으로 참조로 포함된다.
Figure pct00097
Figure pct00098
Figure pct00099
Figure pct00100
Figure pct00101
Figure pct00102
Figure pct00103
Figure pct00104
Figure pct00105
SEQUENCE LISTING <110> THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM <120> COMPOSITIONS AND METHODS FOR CORRECTING DYSTROPHIN MUTATIONS IN HUMAN CARDIOMYOCYTES <130> EXON-007/01WO 332150-2029 <140> Not Yet Assigned <141> 2019-01-31 <150> 62/624,748 <151> 2018-01-31 <160> 2569 <170> PatentIn version 3.5 <210> 1 <211> 63 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1 tataaggaaa aaccaagcac tcagccagtg aagctgccag tcagactgtt actctagtga 60 cac 63 <210> 2 <211> 18 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <400> 2 Tyr Lys Glu Lys Pro Ser Thr Gln Pro Val Lys Leu Pro Val Arg Leu 1 5 10 15 Leu Leu <210> 3 <211> 18 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 3 ccagtgaagg caacactg 18 <210> 4 <211> 6 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <400> 4 Gln Pro Val Lys Ala Thr 1 5 <210> 5 <211> 3685 <212> PRT <213> Homo sapiens <400> 5 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Leu Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser 1775 1780 1785 Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln 1790 1795 1800 Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu 1805 1810 1815 Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn 1820 1825 1830 Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys 1835 1840 1845 Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp 1850 1855 1860 Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln 1865 1870 1875 Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu 1880 1885 1890 Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp 1895 1900 1905 Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys 1910 1915 1920 Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu 1925 1930 1935 Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser 1940 1945 1950 Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg 1955 1960 1965 Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met 1970 1975 1980 Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser 1985 1990 1995 Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu 2000 2005 2010 Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe 2015 2020 2025 Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp 2030 2035 2040 Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys 2045 2050 2055 Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 2060 2065 2070 Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 2075 2080 2085 Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 2090 2095 2100 Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 2105 2110 2115 Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro 2120 2125 2130 Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu 2135 2140 2145 Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 2150 2155 2160 Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala 2165 2170 2175 Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln 2180 2185 2190 Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu 2195 2200 2205 Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe 2210 2215 2220 Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu 2225 2230 2235 Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val 2240 2245 2250 Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys 2255 2260 2265 Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile 2270 2275 2280 Ser Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr 2285 2290 2295 Asn Leu Gln Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln 2300 2305 2310 Gly Glu Ile Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys 2315 2320 2325 Lys Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp 2330 2335 2340 Leu Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn 2345 2350 2355 Gln Glu Gly Pro Phe Asp Val Gln Glu Thr Glu Ile Ala Val Gln 2360 2365 2370 Ala Lys Gln Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His 2375 2380 2385 Leu Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu 2390 2395 2400 Glu Asp Leu Ser Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln 2405 2410 2415 Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr 2420 2425 2430 Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro 2435 2440 2445 Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser 2450 2455 2460 Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala 2465 2470 2475 Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile 2480 2485 2490 Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 2495 2500 2505 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg 2510 2515 2520 Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys 2525 2530 2535 Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg 2540 2545 2550 Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu 2555 2560 2565 Gln Asn Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr 2570 2575 2580 Gln Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln 2585 2590 2595 Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val 2600 2605 2610 Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys 2615 2620 2625 Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu 2630 2635 2640 Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys 2645 2650 2655 Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile 2660 2665 2670 His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His 2675 2680 2685 Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala 2690 2695 2700 Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala 2705 2710 2715 Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu 2720 2725 2730 Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 2735 2740 2745 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu 2750 2755 2760 Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg 2765 2770 2775 Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser 2780 2785 2790 Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys 2795 2800 2805 Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu 2810 2815 2820 Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe 2825 2830 2835 Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg 2840 2845 2850 Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr 2855 2860 2865 Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 2870 2875 2880 Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln 2885 2890 2895 Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr 2900 2905 2910 Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys 2915 2920 2925 Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr 2930 2935 2940 Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly 2945 2950 2955 Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp 2960 2965 2970 His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 2975 2980 2985 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 2990 2995 3000 Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 3005 3010 3015 Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 3020 3025 3030 Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala 3035 3040 3045 Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg 3050 3055 3060 Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 3065 3070 3075 Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln 3080 3085 3090 Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr 3095 3100 3105 Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu 3110 3115 3120 Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu 3125 3130 3135 Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys 3140 3145 3150 Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu 3155 3160 3165 Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu 3170 3175 3180 Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser 3185 3190 3195 Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp 3200 3205 3210 Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 3215 3220 3225 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln 3230 3235 3240 Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn 3245 3250 3255 Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys 3260 3265 3270 Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu 3275 3280 3285 Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala 3290 3295 3300 Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu 3305 3310 3315 Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn 3320 3325 3330 Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys 3335 3340 3345 Gly His Lys Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr 3350 3355 3360 Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn 3365 3370 3375 Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly 3380 3385 3390 Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr 3395 3400 3405 Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala 3410 3415 3420 Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu 3425 3430 3435 His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser 3440 3445 3450 Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu 3455 3460 3465 His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser 3470 3475 3480 Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu 3485 3490 3495 Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu 3500 3505 3510 Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys 3515 3520 3525 Gln Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro 3530 3535 3540 Glu Met Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu 3545 3550 3555 Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu 3560 3565 3570 Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser 3575 3580 3585 Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu 3590 3595 3600 Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr Ser Leu 3605 3610 3615 Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val Val Gly 3620 3625 3630 Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu Ser Pro 3635 3640 3645 Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln Leu 3650 3655 3660 Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys 3665 3670 3675 Pro Met Arg Glu Asp Thr Met 3680 3685 <210> 6 <211> 14069 <212> DNA <213> Homo sapiens <400> 6 cgttaaatgc aaacgctgct ctggctcatg tgtttgctcc gaggtatagg ttttgttcga 60 ctgacgtatc agatagtcag agtggttacc acaccgacgt tgtagcagct gcataataaa 120 tgactgaaag aatcatgtta ggcatgccca cctaacctaa cttgaatcat gcgaaagggg 180 agctgttgga attcaaatag actttctggt tcccagcagt cggcagtaat agaatgcttt 240 caggaagatg acagaatcag gagaaagatg ctgttttgca ctatcttgat ttgttacagc 300 agccaactta ttggcatgat ggagtgacag gaaaaacagc tggcatggaa gatgaaagag 360 aagatgttca aaagaaaaca ttcacaaaat gggtaaatgc acaattttct aagtttggga 420 agcagcatat tgagaacctc ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc 480 tcgaaggcct gacagggcaa aaactgccaa aagaaaaagg atccacaaga gttcatgccc 540 tgaacaatgt caacaaggca ctgcgggttt tgcagaacaa taatgttgat ttagtgaata 600 ttggaagtac tgacatcgta gatggaaatc ataaactgac tcttggtttg atttggaata 660 taatcctcca ctggcaggtc aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa 720 ccaacagtga aaagattctc ctgagctggg tccgacaatc aactcgtaat tatccacagg 780 ttaatgtaat caacttcacc accagctggt ctgatggcct ggctttgaat gctctcatcc 840 atagtcatag gccagaccta tttgactgga atagtgtggt ttgccagcag tcagccacac 900 aacgactgga acatgcattc aacatcgcca gatatcaatt aggcatagag aaactactcg 960 atcctgaaga tgttgatacc acctatccag ataagaagtc catcttaatg tacatcacat 1020 cactcttcca agttttgcct caacaagtga gcattgaagc catccaggaa gtggaaatgt 1080 tgccaaggcc acctaaagtg actaaagaag aacattttca gttacatcat caaatgcact 1140 attctcaaca gatcacggtc agtctagcac agggatatga gagaacttct tcccctaagc 1200 ctcgattcaa gagctatgcc tacacacagg ctgcttatgt caccacctct gaccctacac 1260 ggagcccatt tccttcacag catttggaag ctcctgaaga caagtcattt ggcagttcat 1320 tgatggagag tgaagtaaac ctggaccgtt atcaaacagc tttagaagaa gtattatcgt 1380 ggcttctttc tgctgaggac acattgcaag cacaaggaga gatttctaat gatgtggaag 1440 tggtgaaaga ccagtttcat actcatgagg ggtacatgat ggatttgaca gcccatcagg 1500 gccgggttgg taatattcta caattgggaa gtaagctgat tggaacagga aaattatcag 1560 aagatgaaga aactgaagta caagagcaga tgaatctcct aaattcaaga tgggaatgcc 1620 tcagggtagc tagcatggaa aaacaaagca atttacatag agttttaatg gatctccaga 1680 atcagaaact gaaagagttg aatgactggc taacaaaaac agaagaaaga acaaggaaaa 1740 tggaggaaga gcctcttgga cctgatcttg aagacctaaa acgccaagta caacaacata 1800 aggtgcttca agaagatcta gaacaagaac aagtcagggt caattctctc actcacatgg 1860 tggtggtagt tgatgaatct agtggagatc acgcaactgc tgctttggaa gaacaactta 1920 aggtattggg agatcgatgg gcaaacatct gtagatggac agaagaccgc tgggttcttt 1980 tacaagacat ccttctcaaa tggcaacgtc ttactgaaga acagtgcctt tttagtgcat 2040 ggctttcaga aaaagaagat gcagtgaaca agattcacac aactggcttt aaagatcaaa 2100 atgaaatgtt atcaagtctt caaaaactgg ccgttttaaa agcggatcta gaaaagaaaa 2160 agcaatccat gggcaaactg tattcactca aacaagatct tctttcaaca ctgaagaata 2220 agtcagtgac ccagaagacg gaagcatggc tggataactt tgcccggtgt tgggataatt 2280 tagtccaaaa acttgaaaag agtacagcac agatttcaca ggctgtcacc accactcagc 2340 catcactaac acagacaact gtaatggaaa cagtaactac ggtgaccaca agggaacaga 2400 tcctggtaaa gcatgctcaa gaggaacttc caccaccacc tccccaaaag aagaggcaga 2460 ttactgtgga ttctgaaatt aggaaaaggt tggatgttga tataactgaa cttcacagct 2520 ggattactcg ctcagaagct gtgttgcaga gtcctgaatt tgcaatcttt cggaaggaag 2580 gcaacttctc agacttaaaa gaaaaagtca atgccataga gcgagaaaaa gctgagaagt 2640 tcagaaaact gcaagatgcc agcagatcag ctcaggccct ggtggaacag atggtgaatg 2700 agggtgttaa tgcagatagc atcaaacaag cctcagaaca actgaacagc cggtggatcg 2760 aattctgcca gttgctaagt gagagactta actggctgga gtatcagaac aacatcatcg 2820 ctttctataa tcagctacaa caattggagc agatgacaac tactgctgaa aactggttga 2880 aaatccaacc caccacccca tcagagccaa cagcaattaa aagtcagtta aaaatttgta 2940 aggatgaagt caaccggcta tcaggtcttc aacctcaaat tgaacgatta aaaattcaaa 3000 gcatagccct gaaagagaaa ggacaaggac ccatgttcct ggatgcagac tttgtggcct 3060 ttacaaatca ttttaagcaa gtcttttctg atgtgcaggc cagagagaaa gagctacaga 3120 caatttttga cactttgcca ccaatgcgct atcaggagac catgagtgcc atcaggacat 3180 gggtccagca gtcagaaacc aaactctcca tacctcaact tagtgtcacc gactatgaaa 3240 tcatggagca gagactcggg gaattgcagg ctttacaaag ttctctgcaa gagcaacaaa 3300 gtggcctata ctatctcagc accactgtga aagagatgtc gaagaaagcg ccctctgaaa 3360 ttagccggaa atatcaatca gaatttgaag aaattgaggg acgctggaag aagctctcct 3420 cccagctggt tgagcattgt caaaagctag aggagcaaat gaataaactc cgaaaaattc 3480 agaatcacat acaaaccctg aagaaatgga tggctgaagt tgatgttttt ctgaaggagg 3540 aatggcctgc ccttggggat tcagaaattc taaaaaagca gctgaaacag tgcagacttt 3600 tagtcagtga tattcagaca attcagccca gtctaaacag tgtcaatgaa ggtgggcaga 3660 agataaagaa tgaagcagag ccagagtttg cttcgagact tgagacagaa ctcaaagaac 3720 ttaacactca gtgggatcac atgtgccaac aggtctatgc cagaaaggag gccttgaagg 3780 gaggtttgga gaaaactgta agcctccaga aagatctatc agagatgcac gaatggatga 3840 cacaagctga agaagagtat cttgagagag attttgaata taaaactcca gatgaattac 3900 agaaagcagt tgaagagatg aagagagcta aagaagaggc ccaacaaaaa gaagcgaaag 3960 tgaaactcct tactgagtct gtaaatagtg tcatagctca agctccacct gtagcacaag 4020 aggccttaaa aaaggaactt gaaactctaa ccaccaacta ccagtggctc tgcactaggc 4080 tgaatgggaa atgcaagact ttggaagaag tttgggcatg ttggcatgag ttattgtcat 4140 acttggagaa agcaaacaag tggctaaatg aagtagaatt taaacttaaa accactgaaa 4200 acattcctgg cggagctgag gaaatctctg aggtgctaga ttcacttgaa aatttgatgc 4260 gacattcaga ggataaccca aatcagattc gcatattggc acagacccta acagatggcg 4320 gagtcatgga tgagctaatc aatgaggaac ttgagacatt taattctcgt tggagggaac 4380 tacatgaaga ggctgtaagg aggcaaaagt tgcttgaaca gagcatccag tctgcccagg 4440 agactgaaaa atccttacac ttaatccagg agtccctcac attcattgac aagcagttgg 4500 cagcttatat tgcagacaag gtggacgcag ctcaaatgcc tcaggaagcc cagaaaatcc 4560 aatctgattt gacaagtcat gagatcagtt tagaagaaat gaagaaacat aatcagggga 4620 aggaggctgc ccaaagagtc ctgtctcaga ttgatgttgc acagaaaaaa ttacaagatg 4680 tctccatgaa gtttcgatta ttccagaaac cagccaattt tgagcagcgt ctacaagaaa 4740 gtaagatgat tttagatgaa gtgaagatgc acttgcctgc attggaaaca aagagtgtgg 4800 aacaggaagt agtacagtca cagctaaatc attgtgtgaa cttgtataaa agtctgagtg 4860 aagtgaagtc tgaagtggaa atggtgataa agactggacg tcagattgta cagaaaaagc 4920 agacggaaaa tcccaaagaa cttgatgaaa gagtaacagc tttgaaattg cattataatg 4980 agctgggagc aaaggtaaca gaaagaaagc aacagttgga gaaatgcttg aaattgtccc 5040 gtaagatgcg aaaggaaatg aatgtcttga cagaatggct ggcagctaca gatatggaat 5100 tgacaaagag atcagcagtt gaaggaatgc ctagtaattt ggattctgaa gttgcctggg 5160 gaaaggctac tcaaaaagag attgagaaac agaaggtgca cctgaagagt atcacagagg 5220 taggagaggc cttgaaaaca gttttgggca agaaggagac gttggtggaa gataaactca 5280 gtcttctgaa tagtaactgg atagctgtca cctcccgagc agaagagtgg ttaaatcttt 5340 tgttggaata ccagaaacac atggaaactt ttgaccagaa tgtggaccac atcacaaagt 5400 ggatcattca ggctgacaca cttttggatg aatcagagaa aaagaaaccc cagcaaaaag 5460 aagacgtgct taagcgttta aaggcagaac tgaatgacat acgcccaaag gtggactcta 5520 cacgtgacca agcagcaaac ttgatggcaa accgcggtga ccactgcagg aaattagtag 5580 agccccaaat ctcagagctc aaccatcgat ttgcagccat ttcacacaga attaagactg 5640 gaaaggcctc cattcctttg aaggaattgg agcagtttaa ctcagatata caaaaattgc 5700 ttgaaccact ggaggctgaa attcagcagg gggtgaatct gaaagaggaa gacttcaata 5760 aagatatgaa tgaagacaat gagggtactg taaaagaatt gttgcaaaga ggagacaact 5820 tacaacaaag aatcacagat gagagaaagc gagaggaaat aaagataaaa cagcagctgt 5880 tacagacaaa acataatgct ctcaaggatt tgaggtctca aagaagaaaa aaggctctag 5940 aaatttctca tcagtggtat cagtacaaga ggcaggctga tgatctcctg aaatgcttgg 6000 atgacattga aaaaaaatta gccagcctac ctgagcccag agatgaaagg aaaataaagg 6060 aaattgatcg ggaattgcag aagaagaaag aggagctgaa tgcagtgcgt aggcaagctg 6120 agggcttgtc tgaggatggg gccgcaatgg cagtggagcc aactcagatc cagctcagca 6180 agcgctggcg ggaaattgag agcaaatttg ctcagtttcg aagactcaac tttgcacaaa 6240 ttcacactgt ccgtgaagaa acgatgatgg tgatgactga agacatgcct ttggaaattt 6300 cttatgtgcc ttctacttat ttgactgaaa tcactcatgt ctcacaagcc ctattagaag 6360 tggaacaact tctcaatgct cctgacctct gtgctaagga ctttgaagat ctctttaagc 6420 aagaggagtc tctgaagaat ataaaagata gtctacaaca aagctcaggt cggattgaca 6480 ttattcatag caagaagaca gcagcattgc aaagtgcaac gcctgtggaa agggtgaagc 6540 tacaggaagc tctctcccag cttgatttcc aatgggaaaa agttaacaaa atgtacaagg 6600 accgacaagg gcgatttgac agatctgttg agaaatggcg gcgttttcat tatgatataa 6660 agatatttaa tcagtggcta acagaagctg aacagtttct cagaaagaca caaattcctg 6720 agaattggga acatgctaaa tacaaatggt atcttaagga actccaggat ggcattgggc 6780 agcggcaaac tgttgtcaga acattgaatg caactgggga agaaataatt cagcaatcct 6840 caaaaacaga tgccagtatt ctacaggaaa aattgggaag cctgaatctg cggtggcagg 6900 aggtctgcaa acagctgtca gacagaaaaa agaggctaga agaacaaaag aatatcttgt 6960 cagaatttca aagagattta aatgaatttg ttttatggtt ggaggaagca gataacattg 7020 ctagtatccc acttgaacct ggaaaagagc agcaactaaa agaaaagctt gagcaagtca 7080 agttactggt ggaagagttg cccctgcgcc agggaattct caaacaatta aatgaaactg 7140 gaggacccgt gcttgtaagt gctcccataa gcccagaaga gcaagataaa cttgaaaata 7200 agctcaagca gacaaatctc cagtggataa aggtttccag agctttacct gagaaacaag 7260 gagaaattga agctcaaata aaagaccttg ggcagcttga aaaaaagctt gaagaccttg 7320 aagagcagtt aaatcatctg ctgctgtggt tatctcctat taggaatcag ttggaaattt 7380 ataaccaacc aaaccaagaa ggaccatttg acgttcagga aactgaaata gcagttcaag 7440 ctaaacaacc ggatgtggaa gagattttgt ctaaagggca gcatttgtac aaggaaaaac 7500 cagccactca gccagtgaag aggaagttag aagatctgag ctctgagtgg aaggcggtaa 7560 accgtttact tcaagagctg agggcaaagc agcctgacct agctcctgga ctgaccacta 7620 ttggagcctc tcctactcag actgttactc tggtgacaca acctgtggtt actaaggaaa 7680 ctgccatctc caaactagaa atgccatctt ccttgatgtt ggaggtacct gctctggcag 7740 atttcaaccg ggcttggaca gaacttaccg actggctttc tctgcttgat caagttataa 7800 aatcacagag ggtgatggtg ggtgaccttg aggatatcaa cgagatgatc atcaagcaga 7860 aggcaacaat gcaggatttg gaacagaggc gtccccagtt ggaagaactc attaccgctg 7920 cccaaaattt gaaaaacaag accagcaatc aagaggctag aacaatcatt acggatcgaa 7980 ttgaaagaat tcagaatcag tgggatgaag tacaagaaca ccttcagaac cggaggcaac 8040 agttgaatga aatgttaaag gattcaacac aatggctgga agctaaggaa gaagctgagc 8100 aggtcttagg acaggccaga gccaagcttg agtcatggaa ggagggtccc tatacagtag 8160 atgcaatcca aaagaaaatc acagaaacca agcagttggc caaagacctc cgccagtggc 8220 agacaaatgt agatgtggca aatgacttgg ccctgaaact tctccgggat tattctgcag 8280 atgataccag aaaagtccac atgataacag agaatatcaa tgcctcttgg agaagcattc 8340 ataaaagggt gagtgagcga gaggctgctt tggaagaaac tcatagatta ctgcaacagt 8400 tccccctgga cctggaaaag tttcttgcct ggcttacaga agctgaaaca actgccaatg 8460 tcctacagga tgctacccgt aaggaaaggc tcctagaaga ctccaaggga gtaaaagagc 8520 tgatgaaaca atggcaagac ctccaaggtg aaattgaagc tcacacagat gtttatcaca 8580 acctggatga aaacagccaa aaaatcctga gatccctgga aggttccgat gatgcagtcc 8640 tgttacaaag acgtttggat aacatgaact tcaagtggag tgaacttcgg aaaaagtctc 8700 tcaacattag gtcccatttg gaagccagtt ctgaccagtg gaagcgtctg cacctttctc 8760 tgcaggaact tctggtgtgg ctacagctga aagatgatga attaagccgg caggcaccta 8820 ttggaggcga ctttccagca gttcagaagc agaacgatgt acatagggcc ttcaagaggg 8880 aattgaaaac taaagaacct gtaatcatga gtactcttga gactgtacga atatttctga 8940 cagagcagcc tttggaagga ctagagaaac tctaccagga gcccagagag ctgcctcctg 9000 aggagagagc ccagaatgtc actcggcttc tacgaaagca ggctgaggag gtcaatactg 9060 agtgggaaaa attgaacctg cactccgctg actggcagag aaaaatagat gagacccttg 9120 aaagactcca ggaacttcaa gaggccacgg atgagctgga cctcaagctg cgccaagctg 9180 aggtgatcaa gggatcctgg cagcccgtgg gcgatctcct cattgactct ctccaagatc 9240 acctcgagaa agtcaaggca cttcgaggag aaattgcgcc tctgaaagag aacgtgagcc 9300 acgtcaatga ccttgctcgc cagcttacca ctttgggcat tcagctctca ccgtataacc 9360 tcagcactct ggaagacctg aacaccagat ggaagcttct gcaggtggcc gtcgaggacc 9420 gagtcaggca gctgcatgaa gcccacaggg actttggtcc agcatctcag cactttcttt 9480 ccacgtctgt ccagggtccc tgggagagag ccatctcgcc aaacaaagtg ccctactata 9540 tcaaccacga gactcaaaca acttgctggg accatcccaa aatgacagag ctctaccagt 9600 ctttagctga cctgaataat gtcagattct cagcttatag gactgccatg aaactccgaa 9660 gactgcagaa ggccctttgc ttggatctct tgagcctgtc agctgcatgt gatgccttgg 9720 accagcacaa cctcaagcaa aatgaccagc ccatggatat cctgcagatt attaattgtt 9780 tgaccactat ttatgaccgc ctggagcaag agcacaacaa tttggtcaac gtccctctct 9840 gcgtggatat gtgtctgaac tggctgctga atgtttatga tacgggacga acagggagga 9900 tccgtgtcct gtcttttaaa actggcatca tttccctgtg taaagcacat ttggaagaca 9960 agtacagata ccttttcaag caagtggcaa gttcaacagg attttgtgac cagcgcaggc 10020 tgggcctcct tctgcatgat tctatccaaa ttccaagaca gttgggtgaa gttgcatcct 10080 ttgggggcag taacattgag ccaagtgtcc ggagctgctt ccaatttgct aataataagc 10140 cagagatcga agcggccctc ttcctagact ggatgagact ggaaccccag tccatggtgt 10200 ggctgcccgt cctgcacaga gtggctgctg cagaaactgc caagcatcag gccaaatgta 10260 acatctgcaa agagtgtcca atcattggat tcaggtacag gagtctaaag cactttaatt 10320 atgacatctg ccaaagctgc tttttttctg gtcgagttgc aaaaggccat aaaatgcact 10380 atcccatggt ggaatattgc actccgacta catcaggaga agatgttcga gactttgcca 10440 aggtactaaa aaacaaattt cgaaccaaaa ggtattttgc gaagcatccc cgaatgggct 10500 acctgccagt gcagactgtc ttagaggggg acaacatgga aactcccgtt actctgatca 10560 acttctggcc agtagattct gcgcctgcct cgtcccctca gctttcacac gatgatactc 10620 attcacgcat tgaacattat gctagcaggc tagcagaaat ggaaaacagc aatggatctt 10680 atctaaatga tagcatctct cctaatgaga gcatagatga tgaacatttg ttaatccagc 10740 attactgcca aagtttgaac caggactccc ccctgagcca gcctcgtagt cctgcccaga 10800 tcttgatttc cttagagagt gaggaaagag gggagctaga gagaatccta gcagatcttg 10860 aggaagaaaa caggaatctg caagcagaat atgaccgtct aaagcagcag cacgaacata 10920 aaggcctgtc cccactgccg tcccctcctg aaatgatgcc cacctctccc cagagtcccc 10980 gggatgctga gctcattgct gaggccaagc tactgcgtca acacaaaggc cgcctggaag 11040 ccaggatgca aatcctggaa gaccacaata aacagctgga gtcacagtta cacaggctaa 11100 ggcagctgct ggagcaaccc caggcagagg ccaaagtgaa tggcacaacg gtgtcctctc 11160 cttctacctc tctacagagg tccgacagca gtcagcctat gctgctccga gtggttggca 11220 gtcaaacttc ggactccatg ggtgaggaag atcttctcag tcctccccag gacacaagca 11280 cagggttaga ggaggtgatg gagcaactca acaactcctt ccctagttca agaggaagaa 11340 atacccctgg aaagccaatg agagaggaca caatgtagga agtcttttcc acatggcaga 11400 tgatttgggc agagcgatgg agtccttagt atcagtcatg acagatgaag aaggagcaga 11460 ataaatgttt tacaactcct gattcccgca tggtttttat aatattcata caacaaagag 11520 gattagacag taagagttta caagaaataa atctatattt ttgtgaaggg tagtggtatt 11580 atactgtaga tttcagtagt ttctaagtct gttattgttt tgttaacaat ggcaggtttt 11640 acacgtctat gcaattgtac aaaaaagtta taagaaaact acatgtaaaa tcttgatagc 11700 taaataactt gccatttctt tatatggaac gcattttggg ttgtttaaaa atttataaca 11760 gttataaaga aagattgtaa actaaagtgt gctttataaa aaaaagttgt ttataaaaac 11820 ccctaaaaac aaaacaaaca cacacacaca cacatacaca cacacacaca aaactttgag 11880 gcagcgcatt gttttgcatc cttttggcgt gatatccata tgaaattcat ggctttttct 11940 ttttttgcat attaaagata agacttcctc taccaccaca ccaaatgact actacacact 12000 gctcatttga gaactgtcag ctgagtgggg caggcttgag ttttcatttc atatatctat 12060 atgtctataa gtatataaat actatagtta tatagataaa gagatacgaa tttctataga 12120 ctgacttttt ccatttttta aatgttcatg tcacatccta atagaaagaa attacttcta 12180 gtcagtcatc caggcttacc tgcttggtct agaatggatt tttcccggag ccggaagcca 12240 ggaggaaact acaccacact aaaacattgt ctacagctcc agatgtttct cattttaaac 12300 aactttccac tgacaacgaa agtaaagtaa agtattggat ttttttaaag ggaacatgtg 12360 aatgaataca caggacttat tatatcagag tgagtaatcg gttggttggt tgattgattg 12420 attgattgat acattcagct tcctgctgct agcaatgcca cgatttagat ttaatgatgc 12480 ttcagtggaa atcaatcaga aggtattctg accttgtgaa catcagaagg tattttttaa 12540 ctcccaagca gtagcaggac gatgataggg ctggagggct atggattccc agcccatccc 12600 tgtgaaggag taggccactc tttaagtgaa ggattggatg attgttcata atacataaag 12660 ttctctgtaa ttacaactaa attattatgc cctcttctca cagtcaaaag gaactgggtg 12720 gtttggtttt tgttgctttt ttagatttat tgtcccatgt gggatgagtt tttaaatgcc 12780 acaagacata atttaaaata aataaacttt gggaaaaggt gtaaaacagt agccccatca 12840 catttgtgat actgacaggt atcaacccag aagcccatga actgtgtttc catcctttgc 12900 atttctctgc gagtagttcc acacaggttt gtaagtaagt aagaaagaag gcaaattgat 12960 tcaaatgtta caaaaaaacc cttcttggtg gattagacag gttaaatata taaacaaaca 13020 aacaaaaatt gctcaaaaaa gaggagaaaa gctcaagagg aaaagctaag gactggtagg 13080 aaaaagcttt actctttcat gccattttat ttctttttga tttttaaatc attcattcaa 13140 tagataccac cgtgtgacct ataattttgc aaatctgtta cctctgacat caagtgtaat 13200 tagcttttgg agagtgggct gacatcaagt gtaattagct tttggagagt gggttttgtc 13260 cattattaat aattaattaa ttaacatcaa acacggcttc tcatgctatt tctacctcac 13320 tttggttttg gggtgttcct gataattgtg cacacctgag ttcacagctt caccacttgt 13380 ccattgcgtt attttctttt tcctttataa ttctttcttt ttccttcata attttcaaaa 13440 gaaaacccaa agctctaagg taacaaatta ccaaattaca tgaagatttg gtttttgtct 13500 tgcatttttt tcctttatgt gacgctggac cttttcttta cccaaggatt tttaaaactc 13560 agatttaaaa caaggggtta ctttacatcc tactaagaag tttaagtaag taagtttcat 13620 tctaaaatca gaggtaaata gagtgcataa ataattttgt tttaatcttt ttgtttttct 13680 tttagacaca ttagctctgg agtgagtctg tcataatatt tgaacaaaaa ttgagagctt 13740 tattgctgca ttttaagcat aattaatttg gacattattt cgtgttgtgt tctttataac 13800 caccaagtat taaactgtaa atcataatgt aactgaagca taaacatcac atggcatgtt 13860 ttgtcattgt tttcaggtac tgagttctta cttgagtatc ataatatatt gtgttttaac 13920 accaacactg taacatttac gaattatttt tttaaacttc agttttactg cattttcaca 13980 acatatcaga cttcaccaaa tatatgcctt actattgtat tatagtactg ctttactgtg 14040 tatctcaata aagcacgcag ttatgttac 14069 <210> 7 <211> 3677 <212> PRT <213> Homo sapiens <400> 7 Met Glu Asp Glu Arg Glu Asp Val Gln Lys Lys Thr Phe Thr Lys Trp 1 5 10 15 Val Asn Ala Gln Phe Ser Lys Phe Gly Lys Gln His Ile Glu Asn Leu 20 25 30 Phe Ser Asp Leu Gln Asp Gly Arg Arg Leu Leu Asp Leu Leu Glu Gly 35 40 45 Leu Thr Gly Gln Lys Leu Pro Lys Glu Lys Gly Ser Thr Arg Val His 50 55 60 Ala Leu Asn Asn Val Asn Lys Ala Leu Arg Val Leu Gln Asn Asn Asn 65 70 75 80 Val Asp Leu Val Asn Ile Gly Ser Thr Asp Ile Val Asp Gly Asn His 85 90 95 Lys Leu Thr Leu Gly Leu Ile Trp Asn Ile Ile Leu His Trp Gln Val 100 105 110 Lys Asn Val Met Lys Asn Ile Met Ala Gly Leu Gln Gln Thr Asn Ser 115 120 125 Glu Lys Ile Leu Leu Ser Trp Val Arg Gln Ser Thr Arg Asn Tyr Pro 130 135 140 Gln Val Asn Val Ile Asn Phe Thr Thr Ser Trp Ser Asp Gly Leu Ala 145 150 155 160 Leu Asn Ala Leu Ile His Ser His Arg Pro Asp Leu Phe Asp Trp Asn 165 170 175 Ser Val Val Cys Gln Gln Ser Ala Thr Gln Arg Leu Glu His Ala Phe 180 185 190 Asn Ile Ala Arg Tyr Gln Leu Gly Ile Glu Lys Leu Leu Asp Pro Glu 195 200 205 Asp Val Asp Thr Thr Tyr Pro Asp Lys Lys Ser Ile Leu Met Tyr Ile 210 215 220 Thr Ser Leu Phe Gln Val Leu Pro Gln Gln Val Ser Ile Glu Ala Ile 225 230 235 240 Gln Glu Val Glu Met Leu Pro Arg Pro Pro Lys Val Thr Lys Glu Glu 245 250 255 His Phe Gln Leu His His Gln Met His Tyr Ser Gln Gln Ile Thr Val 260 265 270 Ser Leu Ala Gln Gly Tyr Glu Arg Thr Ser Ser Pro Lys Pro Arg Phe 275 280 285 Lys Ser Tyr Ala Tyr Thr Gln Ala Ala Tyr Val Thr Thr Ser Asp Pro 290 295 300 Thr Arg Ser Pro Phe Pro Ser Gln His Leu Glu Ala Pro Glu Asp Lys 305 310 315 320 Ser Phe Gly Ser Ser Leu Met Glu Ser Glu Val Asn Leu Asp Arg Tyr 325 330 335 Gln Thr Ala Leu Glu Glu Val Leu Ser Trp Leu Leu Ser Ala Glu Asp 340 345 350 Thr Leu Gln Ala Gln Gly Glu Ile Ser Asn Asp Val Glu Val Val Lys 355 360 365 Asp Gln Phe His Thr His Glu Gly Tyr Met Met Asp Leu Thr Ala His 370 375 380 Gln Gly Arg Val Gly Asn Ile Leu Gln Leu Gly Ser Lys Leu Ile Gly 385 390 395 400 Thr Gly Lys Leu Ser Glu Asp Glu Glu Thr Glu Val Gln Glu Gln Met 405 410 415 Asn Leu Leu Asn Ser Arg Trp Glu Cys Leu Arg Val Ala Ser Met Glu 420 425 430 Lys Gln Ser Asn Leu His Arg Val Leu Met Asp Leu Gln Asn Gln Lys 435 440 445 Leu Lys Glu Leu Asn Asp Trp Leu Thr Lys Thr Glu Glu Arg Thr Arg 450 455 460 Lys Met Glu Glu Glu Pro Leu Gly Pro Asp Leu Glu Asp Leu Lys Arg 465 470 475 480 Gln Val Gln Gln His Lys Val Leu Gln Glu Asp Leu Glu Gln Glu Gln 485 490 495 Val Arg Val Asn Ser Leu Thr His Met Val Val Val Val Asp Glu Ser 500 505 510 Ser Gly Asp His Ala Thr Ala Ala Leu Glu Glu Gln Leu Lys Val Leu 515 520 525 Gly Asp Arg Trp Ala Asn Ile Cys Arg Trp Thr Glu Asp Arg Trp Val 530 535 540 Leu Leu Gln Asp Ile Leu Leu Lys Trp Gln Arg Leu Thr Glu Glu Gln 545 550 555 560 Cys Leu Phe Ser Ala Trp Leu Ser Glu Lys Glu Asp Ala Val Asn Lys 565 570 575 Ile His Thr Thr Gly Phe Lys Asp Gln Asn Glu Met Leu Ser Ser Leu 580 585 590 Gln Lys Leu Ala Val Leu Lys Ala Asp Leu Glu Lys Lys Lys Gln Ser 595 600 605 Met Gly Lys Leu Tyr Ser Leu Lys Gln Asp Leu Leu Ser Thr Leu Lys 610 615 620 Asn Lys Ser Val Thr Gln Lys Thr Glu Ala Trp Leu Asp Asn Phe Ala 625 630 635 640 Arg Cys Trp Asp Asn Leu Val Gln Lys Leu Glu Lys Ser Thr Ala Gln 645 650 655 Ile Ser Gln Ala Val Thr Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr 660 665 670 Val Met Glu Thr Val Thr Thr Val Thr Thr Arg Glu Gln Ile Leu Val 675 680 685 Lys His Ala Gln Glu Glu Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg 690 695 700 Gln Ile Thr Val Asp Ser Glu Ile Arg Lys Arg Leu Asp Val Asp Ile 705 710 715 720 Thr Glu Leu His Ser Trp Ile Thr Arg Ser Glu Ala Val Leu Gln Ser 725 730 735 Pro Glu Phe Ala Ile Phe Arg Lys Glu Gly Asn Phe Ser Asp Leu Lys 740 745 750 Glu Lys Val Asn Ala Ile Glu Arg Glu Lys Ala Glu Lys Phe Arg Lys 755 760 765 Leu Gln Asp Ala Ser Arg Ser Ala Gln Ala Leu Val Glu Gln Met Val 770 775 780 Asn Glu Gly Val Asn Ala Asp Ser Ile Lys Gln Ala Ser Glu Gln Leu 785 790 795 800 Asn Ser Arg Trp Ile Glu Phe Cys Gln Leu Leu Ser Glu Arg Leu Asn 805 810 815 Trp Leu Glu Tyr Gln Asn Asn Ile Ile Ala Phe Tyr Asn Gln Leu Gln 820 825 830 Gln Leu Glu Gln Met Thr Thr Thr Ala Glu Asn Trp Leu Lys Ile Gln 835 840 845 Pro Thr Thr Pro Ser Glu Pro Thr Ala Ile Lys Ser Gln Leu Lys Ile 850 855 860 Cys Lys Asp Glu Val Asn Arg Leu Ser Gly Leu Gln Pro Gln Ile Glu 865 870 875 880 Arg Leu Lys Ile Gln Ser Ile Ala Leu Lys Glu Lys Gly Gln Gly Pro 885 890 895 Met Phe Leu Asp Ala Asp Phe Val Ala Phe Thr Asn His Phe Lys Gln 900 905 910 Val Phe Ser Asp Val Gln Ala Arg Glu Lys Glu Leu Gln Thr Ile Phe 915 920 925 Asp Thr Leu Pro Pro Met Arg Tyr Gln Glu Thr Met Ser Ala Ile Arg 930 935 940 Thr Trp Val Gln Gln Ser Glu Thr Lys Leu Ser Ile Pro Gln Leu Ser 945 950 955 960 Val Thr Asp Tyr Glu Ile Met Glu Gln Arg Leu Gly Glu Leu Gln Ala 965 970 975 Leu Gln Ser Ser Leu Gln Glu Gln Gln Ser Gly Leu Tyr Tyr Leu Ser 980 985 990 Thr Thr Val Lys Glu Met Ser Lys Lys Ala Pro Ser Glu Ile Ser Arg 995 1000 1005 Lys Tyr Gln Ser Glu Phe Glu Glu Ile Glu Gly Arg Trp Lys Lys 1010 1015 1020 Leu Ser Ser Gln Leu Val Glu His Cys Gln Lys Leu Glu Glu Gln 1025 1030 1035 Met Asn Lys Leu Arg Lys Ile Gln Asn His Ile Gln Thr Leu Lys 1040 1045 1050 Lys Trp Met Ala Glu Val Asp Val Phe Leu Lys Glu Glu Trp Pro 1055 1060 1065 Ala Leu Gly Asp Ser Glu Ile Leu Lys Lys Gln Leu Lys Gln Cys 1070 1075 1080 Arg Leu Leu Val Ser Asp Ile Gln Thr Ile Gln Pro Ser Leu Asn 1085 1090 1095 Ser Val Asn Glu Gly Gly Gln Lys Ile Lys Asn Glu Ala Glu Pro 1100 1105 1110 Glu Phe Ala Ser Arg Leu Glu Thr Glu Leu Lys Glu Leu Asn Thr 1115 1120 1125 Gln Trp Asp His Met Cys Gln Gln Val Tyr Ala Arg Lys Glu Ala 1130 1135 1140 Leu Lys Gly Gly Leu Glu Lys Thr Val Ser Leu Gln Lys Asp Leu 1145 1150 1155 Ser Glu Met His Glu Trp Met Thr Gln Ala Glu Glu Glu Tyr Leu 1160 1165 1170 Glu Arg Asp Phe Glu Tyr Lys Thr Pro Asp Glu Leu Gln Lys Ala 1175 1180 1185 Val Glu Glu Met Lys Arg Ala Lys Glu Glu Ala Gln Gln Lys Glu 1190 1195 1200 Ala Lys Val Lys Leu Leu Thr Glu Ser Val Asn Ser Val Ile Ala 1205 1210 1215 Gln Ala Pro Pro Val Ala Gln Glu Ala Leu Lys Lys Glu Leu Glu 1220 1225 1230 Thr Leu Thr Thr Asn Tyr Gln Trp Leu Cys Thr Arg Leu Asn Gly 1235 1240 1245 Lys Cys Lys Thr Leu Glu Glu Val Trp Ala Cys Trp His Glu Leu 1250 1255 1260 Leu Ser Tyr Leu Glu Lys Ala Asn Lys Trp Leu Asn Glu Val Glu 1265 1270 1275 Phe Lys Leu Lys Thr Thr Glu Asn Ile Pro Gly Gly Ala Glu Glu 1280 1285 1290 Ile Ser Glu Val Leu Asp Ser Leu Glu Asn Leu Met Arg His Ser 1295 1300 1305 Glu Asp Asn Pro Asn Gln Ile Arg Ile Leu Ala Gln Thr Leu Thr 1310 1315 1320 Asp Gly Gly Val Met Asp Glu Leu Ile Asn Glu Glu Leu Glu Thr 1325 1330 1335 Phe Asn Ser Arg Trp Arg Glu Leu His Glu Glu Ala Val Arg Arg 1340 1345 1350 Gln Lys Leu Leu Glu Gln Ser Ile Gln Ser Ala Gln Glu Thr Glu 1355 1360 1365 Lys Ser Leu His Leu Ile Gln Glu Ser Leu Thr Phe Ile Asp Lys 1370 1375 1380 Gln Leu Ala Ala Tyr Ile Ala Asp Lys Val Asp Ala Ala Gln Met 1385 1390 1395 Pro Gln Glu Ala Gln Lys Ile Gln Ser Asp Leu Thr Ser His Glu 1400 1405 1410 Ile Ser Leu Glu Glu Met Lys Lys His Asn Gln Gly Lys Glu Ala 1415 1420 1425 Ala Gln Arg Val Leu Ser Gln Ile Asp Val Ala Gln Lys Lys Leu 1430 1435 1440 Gln Asp Val Ser Met Lys Phe Arg Leu Phe Gln Lys Pro Ala Asn 1445 1450 1455 Phe Glu Gln Arg Leu Gln Glu Ser Lys Met Ile Leu Asp Glu Val 1460 1465 1470 Lys Met His Leu Pro Ala Leu Glu Thr Lys Ser Val Glu Gln Glu 1475 1480 1485 Val Val Gln Ser Gln Leu Asn His Cys Val Asn Leu Tyr Lys Ser 1490 1495 1500 Leu Ser Glu Val Lys Ser Glu Val Glu Met Val Ile Lys Thr Gly 1505 1510 1515 Arg Gln Ile Val Gln Lys Lys Gln Thr Glu Asn Pro Lys Glu Leu 1520 1525 1530 Asp Glu Arg Val Thr Ala Leu Lys Leu His Tyr Asn Glu Leu Gly 1535 1540 1545 Ala Lys Val Thr Glu Arg Lys Gln Gln Leu Glu Lys Cys Leu Lys 1550 1555 1560 Leu Ser Arg Lys Met Arg Lys Glu Met Asn Val Leu Thr Glu Trp 1565 1570 1575 Leu Ala Ala Thr Asp Met Glu Leu Thr Lys Arg Ser Ala Val Glu 1580 1585 1590 Gly Met Pro Ser Asn Leu Asp Ser Glu Val Ala Trp Gly Lys Ala 1595 1600 1605 Thr Gln Lys Glu Ile Glu Lys Gln Lys Val His Leu Lys Ser Ile 1610 1615 1620 Thr Glu Val Gly Glu Ala Leu Lys Thr Val Leu Gly Lys Lys Glu 1625 1630 1635 Thr Leu Val Glu Asp Lys Leu Ser Leu Leu Asn Ser Asn Trp Ile 1640 1645 1650 Ala Val Thr Ser Arg Ala Glu Glu Trp Leu Asn Leu Leu Leu Glu 1655 1660 1665 Tyr Gln Lys His Met Glu Thr Phe Asp Gln Asn Val Asp His Ile 1670 1675 1680 Thr Lys Trp Ile Ile Gln Ala Asp Thr Leu Leu Asp Glu Ser Glu 1685 1690 1695 Lys Lys Lys Pro Gln Gln Lys Glu Asp Val Leu Lys Arg Leu Lys 1700 1705 1710 Ala Glu Leu Asn Asp Ile Arg Pro Lys Val Asp Ser Thr Arg Asp 1715 1720 1725 Gln Ala Ala Asn Leu Met Ala Asn Arg Gly Asp His Cys Arg Lys 1730 1735 1740 Leu Val Glu Pro Gln Ile Ser Glu Leu Asn His Arg Phe Ala Ala 1745 1750 1755 Ile Ser His Arg Ile Lys Thr Gly Lys Ala Ser Ile Pro Leu Lys 1760 1765 1770 Glu Leu Glu Gln Phe Asn Ser Asp Ile Gln Lys Leu Leu Glu Pro 1775 1780 1785 Leu Glu Ala Glu Ile Gln Gln Gly Val Asn Leu Lys Glu Glu Asp 1790 1795 1800 Phe Asn Lys Asp Met Asn Glu Asp Asn Glu Gly Thr Val Lys Glu 1805 1810 1815 Leu Leu Gln Arg Gly Asp Asn Leu Gln Gln Arg Ile Thr Asp Glu 1820 1825 1830 Arg Lys Arg Glu Glu Ile Lys Ile Lys Gln Gln Leu Leu Gln Thr 1835 1840 1845 Lys His Asn Ala Leu Lys Asp Leu Arg Ser Gln Arg Arg Lys Lys 1850 1855 1860 Ala Leu Glu Ile Ser His Gln Trp Tyr Gln Tyr Lys Arg Gln Ala 1865 1870 1875 Asp Asp Leu Leu Lys Cys Leu Asp Asp Ile Glu Lys Lys Leu Ala 1880 1885 1890 Ser Leu Pro Glu Pro Arg Asp Glu Arg Lys Ile Lys Glu Ile Asp 1895 1900 1905 Arg Glu Leu Gln Lys Lys Lys Glu Glu Leu Asn Ala Val Arg Arg 1910 1915 1920 Gln Ala Glu Gly Leu Ser Glu Asp Gly Ala Ala Met Ala Val Glu 1925 1930 1935 Pro Thr Gln Ile Gln Leu Ser Lys Arg Trp Arg Glu Ile Glu Ser 1940 1945 1950 Lys Phe Ala Gln Phe Arg Arg Leu Asn Phe Ala Gln Ile His Thr 1955 1960 1965 Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu 1970 1975 1980 Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His 1985 1990 1995 Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro 2000 2005 2010 Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu 2015 2020 2025 Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg 2030 2035 2040 Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala 2045 2050 2055 Thr Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu 2060 2065 2070 Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln 2075 2080 2085 Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr 2090 2095 2100 Asp Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe 2105 2110 2115 Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys Tyr 2120 2125 2130 Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln 2135 2140 2145 Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln 2150 2155 2160 Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly 2165 2170 2175 Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser Asp 2180 2185 2190 Arg Lys Lys Arg Leu Glu Glu Gln Lys Asn Ile Leu Ser Glu Phe 2195 2200 2205 Gln Arg Asp Leu Asn Glu Phe Val Leu Trp Leu Glu Glu Ala Asp 2210 2215 2220 Asn Ile Ala Ser Ile Pro Leu Glu Pro Gly Lys Glu Gln Gln Leu 2225 2230 2235 Lys Glu Lys Leu Glu Gln Val Lys Leu Leu Val Glu Glu Leu Pro 2240 2245 2250 Leu Arg Gln Gly Ile Leu Lys Gln Leu Asn Glu Thr Gly Gly Pro 2255 2260 2265 Val Leu Val Ser Ala Pro Ile Ser Pro Glu Glu Gln Asp Lys Leu 2270 2275 2280 Glu Asn Lys Leu Lys Gln Thr Asn Leu Gln Trp Ile Lys Val Ser 2285 2290 2295 Arg Ala Leu Pro Glu Lys Gln Gly Glu Ile Glu Ala Gln Ile Lys 2300 2305 2310 Asp Leu Gly Gln Leu Glu Lys Lys Leu Glu Asp Leu Glu Glu Gln 2315 2320 2325 Leu Asn His Leu Leu Leu Trp Leu Ser Pro Ile Arg Asn Gln Leu 2330 2335 2340 Glu Ile Tyr Asn Gln Pro Asn Gln Glu Gly Pro Phe Asp Val Gln 2345 2350 2355 Glu Thr Glu Ile Ala Val Gln Ala Lys Gln Pro Asp Val Glu Glu 2360 2365 2370 Ile Leu Ser Lys Gly Gln His Leu Tyr Lys Glu Lys Pro Ala Thr 2375 2380 2385 Gln Pro Val Lys Arg Lys Leu Glu Asp Leu Ser Ser Glu Trp Lys 2390 2395 2400 Ala Val Asn Arg Leu Leu Gln Glu Leu Arg Ala Lys Gln Pro Asp 2405 2410 2415 Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr 2420 2425 2430 Val Thr Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile 2435 2440 2445 Ser Lys Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala 2450 2455 2460 Leu Ala Asp Phe Asn Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu 2465 2470 2475 Ser Leu Leu Asp Gln Val Ile Lys Ser Gln Arg Val Met Val Gly 2480 2485 2490 Asp Leu Glu Asp Ile Asn Glu Met Ile Ile Lys Gln Lys Ala Thr 2495 2500 2505 Met Gln Asp Leu Glu Gln Arg Arg Pro Gln Leu Glu Glu Leu Ile 2510 2515 2520 Thr Ala Ala Gln Asn Leu Lys Asn Lys Thr Ser Asn Gln Glu Ala 2525 2530 2535 Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg Ile Gln Asn Gln Trp 2540 2545 2550 Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg Gln Gln Leu Asn 2555 2560 2565 Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala Lys Glu Glu 2570 2575 2580 Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu Ser Trp 2585 2590 2595 Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile Thr 2600 2605 2610 Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn 2615 2620 2625 Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr 2630 2635 2640 Ser Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile 2645 2650 2655 Asn Ala Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu 2660 2665 2670 Ala Ala Leu Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu 2675 2680 2685 Asp Leu Glu Lys Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr 2690 2695 2700 Ala Asn Val Leu Gln Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu 2705 2710 2715 Asp Ser Lys Gly Val Lys Glu Leu Met Lys Gln Trp Gln Asp Leu 2720 2725 2730 Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr His Asn Leu Asp 2735 2740 2745 Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp 2750 2755 2760 Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn Phe Lys Trp 2765 2770 2775 Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His Leu Glu 2780 2785 2790 Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu 2795 2800 2805 Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln 2810 2815 2820 Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp 2825 2830 2835 Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro Val 2840 2845 2850 Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln 2855 2860 2865 Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu 2870 2875 2880 Pro Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys 2885 2890 2895 Gln Ala Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His 2900 2905 2910 Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu 2915 2920 2925 Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg 2930 2935 2940 Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu 2945 2950 2955 Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu 2960 2965 2970 Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn 2975 2980 2985 Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro 2990 2995 3000 Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu 3005 3010 3015 Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala 3020 3025 3030 His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser 3035 3040 3045 Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro 3050 3055 3060 Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro 3065 3070 3075 Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val 3080 3085 3090 Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 3095 3100 3105 Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp 3110 3115 3120 Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp 3125 3130 3135 Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu 3140 3145 3150 Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp 3155 3160 3165 Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr 3170 3175 3180 Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu 3185 3190 3195 Cys Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln 3200 3205 3210 Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu 3215 3220 3225 Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val 3230 3235 3240 Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys 3245 3250 3255 Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu Phe 3260 3265 3270 Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met Val Trp Leu Pro 3275 3280 3285 Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala 3290 3295 3300 Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe Arg Tyr 3305 3310 3315 Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys Phe 3320 3325 3330 Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 3335 3340 3345 Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp 3350 3355 3360 Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe 3365 3370 3375 Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu 3380 3385 3390 Glu Gly Asp Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp 3395 3400 3405 Pro Val Asp Ser Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp 3410 3415 3420 Asp Thr His Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu 3425 3430 3435 Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro 3440 3445 3450 Asn Glu Ser Ile Asp Asp Glu His Leu Leu Ile Gln His Tyr Cys 3455 3460 3465 Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro 3470 3475 3480 Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu Arg Gly Glu Leu 3485 3490 3495 Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn Leu Gln 3500 3505 3510 Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys Gly Leu 3515 3520 3525 Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro Gln 3530 3535 3540 Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg 3545 3550 3555 Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu Asp 3560 3565 3570 His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu 3575 3580 3585 Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val 3590 3595 3600 Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro 3605 3610 3615 Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly 3620 3625 3630 Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu 3635 3640 3645 Glu Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg 3650 3655 3660 Gly Arg Asn Thr Pro Gly Lys Pro Met Arg Glu Asp Thr Met 3665 3670 3675 <210> 8 <211> 13993 <212> DNA <213> Homo sapiens <400> 8 tcctggcatc agttactgtg ttgactcact cagtgttggg atcactcact ttccccctac 60 aggactcaga tctgggaggc aattaccttc ggagaaaaac gaataggaaa aactgaagtg 120 ttactttttt taaagctgct gaagtttgtt ggtttctcat tgtttttaag cctactggag 180 caataaagtt tgaagaactt ttaccaggtt ttttttatcg ctgccttgat atacactttt 240 caaaatgctt tggtgggaag aagtagagga ctgttatgaa agagaagatg ttcaaaagaa 300 aacattcaca aaatgggtaa atgcacaatt ttctaagttt gggaagcagc atattgagaa 360 cctcttcagt gacctacagg atgggaggcg cctcctagac ctcctcgaag gcctgacagg 420 gcaaaaactg ccaaaagaaa aaggatccac aagagttcat gccctgaaca atgtcaacaa 480 ggcactgcgg gttttgcaga acaataatgt tgatttagtg aatattggaa gtactgacat 540 cgtagatgga aatcataaac tgactcttgg tttgatttgg aatataatcc tccactggca 600 ggtcaaaaat gtaatgaaaa atatcatggc tggattgcaa caaaccaaca gtgaaaagat 660 tctcctgagc tgggtccgac aatcaactcg taattatcca caggttaatg taatcaactt 720 caccaccagc tggtctgatg gcctggcttt gaatgctctc atccatagtc ataggccaga 780 cctatttgac tggaatagtg tggtttgcca gcagtcagcc acacaacgac tggaacatgc 840 attcaacatc gccagatatc aattaggcat agagaaacta ctcgatcctg aagatgttga 900 taccacctat ccagataaga agtccatctt aatgtacatc acatcactct tccaagtttt 960 gcctcaacaa gtgagcattg aagccatcca ggaagtggaa atgttgccaa ggccacctaa 1020 agtgactaaa gaagaacatt ttcagttaca tcatcaaatg cactattctc aacagatcac 1080 ggtcagtcta gcacagggat atgagagaac ttcttcccct aagcctcgat tcaagagcta 1140 tgcctacaca caggctgctt atgtcaccac ctctgaccct acacggagcc catttccttc 1200 acagcatttg gaagctcctg aagacaagtc atttggcagt tcattgatgg agagtgaagt 1260 aaacctggac cgttatcaaa cagctttaga agaagtatta tcgtggcttc tttctgctga 1320 ggacacattg caagcacaag gagagatttc taatgatgtg gaagtggtga aagaccagtt 1380 tcatactcat gaggggtaca tgatggattt gacagcccat cagggccggg ttggtaatat 1440 tctacaattg ggaagtaagc tgattggaac aggaaaatta tcagaagatg aagaaactga 1500 agtacaagag cagatgaatc tcctaaattc aagatgggaa tgcctcaggg tagctagcat 1560 ggaaaaacaa agcaatttac atagagtttt aatggatctc cagaatcaga aactgaaaga 1620 gttgaatgac tggctaacaa aaacagaaga aagaacaagg aaaatggagg aagagcctct 1680 tggacctgat cttgaagacc taaaacgcca agtacaacaa cataaggtgc ttcaagaaga 1740 tctagaacaa gaacaagtca gggtcaattc tctcactcac atggtggtgg tagttgatga 1800 atctagtgga gatcacgcaa ctgctgcttt ggaagaacaa cttaaggtat tgggagatcg 1860 atgggcaaac atctgtagat ggacagaaga ccgctgggtt cttttacaag acatccttct 1920 caaatggcaa cgtcttactg aagaacagtg cctttttagt gcatggcttt cagaaaaaga 1980 agatgcagtg aacaagattc acacaactgg ctttaaagat caaaatgaaa tgttatcaag 2040 tcttcaaaaa ctggccgttt taaaagcgga tctagaaaag aaaaagcaat ccatgggcaa 2100 actgtattca ctcaaacaag atcttctttc aacactgaag aataagtcag tgacccagaa 2160 gacggaagca tggctggata actttgcccg gtgttgggat aatttagtcc aaaaacttga 2220 aaagagtaca gcacagattt cacaggctgt caccaccact cagccatcac taacacagac 2280 aactgtaatg gaaacagtaa ctacggtgac cacaagggaa cagatcctgg taaagcatgc 2340 tcaagaggaa cttccaccac cacctcccca aaagaagagg cagattactg tggattctga 2400 aattaggaaa aggttggatg ttgatataac tgaacttcac agctggatta ctcgctcaga 2460 agctgtgttg cagagtcctg aatttgcaat ctttcggaag gaaggcaact tctcagactt 2520 aaaagaaaaa gtcaatgcca tagagcgaga aaaagctgag aagttcagaa aactgcaaga 2580 tgccagcaga tcagctcagg ccctggtgga acagatggtg aatgagggtg ttaatgcaga 2640 tagcatcaaa caagcctcag aacaactgaa cagccggtgg atcgaattct gccagttgct 2700 aagtgagaga cttaactggc tggagtatca gaacaacatc atcgctttct ataatcagct 2760 acaacaattg gagcagatga caactactgc tgaaaactgg ttgaaaatcc aacccaccac 2820 cccatcagag ccaacagcaa ttaaaagtca gttaaaaatt tgtaaggatg aagtcaaccg 2880 gctatcaggt cttcaacctc aaattgaacg attaaaaatt caaagcatag ccctgaaaga 2940 gaaaggacaa ggacccatgt tcctggatgc agactttgtg gcctttacaa atcattttaa 3000 gcaagtcttt tctgatgtgc aggccagaga gaaagagcta cagacaattt ttgacacttt 3060 gccaccaatg cgctatcagg agaccatgag tgccatcagg acatgggtcc agcagtcaga 3120 aaccaaactc tccatacctc aacttagtgt caccgactat gaaatcatgg agcagagact 3180 cggggaattg caggctttac aaagttctct gcaagagcaa caaagtggcc tatactatct 3240 cagcaccact gtgaaagaga tgtcgaagaa agcgccctct gaaattagcc ggaaatatca 3300 atcagaattt gaagaaattg agggacgctg gaagaagctc tcctcccagc tggttgagca 3360 ttgtcaaaag ctagaggagc aaatgaataa actccgaaaa attcagaatc acatacaaac 3420 cctgaagaaa tggatggctg aagttgatgt ttttctgaag gaggaatggc ctgcccttgg 3480 ggattcagaa attctaaaaa agcagctgaa acagtgcaga cttttagtca gtgatattca 3540 gacaattcag cccagtctaa acagtgtcaa tgaaggtggg cagaagataa agaatgaagc 3600 agagccagag tttgcttcga gacttgagac agaactcaaa gaacttaaca ctcagtggga 3660 tcacatgtgc caacaggtct atgccagaaa ggaggccttg aagggaggtt tggagaaaac 3720 tgtaagcctc cagaaagatc tatcagagat gcacgaatgg atgacacaag ctgaagaaga 3780 gtatcttgag agagattttg aatataaaac tccagatgaa ttacagaaag cagttgaaga 3840 gatgaagaga gctaaagaag aggcccaaca aaaagaagcg aaagtgaaac tccttactga 3900 gtctgtaaat agtgtcatag ctcaagctcc acctgtagca caagaggcct taaaaaagga 3960 acttgaaact ctaaccacca actaccagtg gctctgcact aggctgaatg ggaaatgcaa 4020 gactttggaa gaagtttggg catgttggca tgagttattg tcatacttgg agaaagcaaa 4080 caagtggcta aatgaagtag aatttaaact taaaaccact gaaaacattc ctggcggagc 4140 tgaggaaatc tctgaggtgc tagattcact tgaaaatttg atgcgacatt cagaggataa 4200 cccaaatcag attcgcatat tggcacagac cctaacagat ggcggagtca tggatgagct 4260 aatcaatgag gaacttgaga catttaattc tcgttggagg gaactacatg aagaggctgt 4320 aaggaggcaa aagttgcttg aacagagcat ccagtctgcc caggagactg aaaaatcctt 4380 acacttaatc caggagtccc tcacattcat tgacaagcag ttggcagctt atattgcaga 4440 caaggtggac gcagctcaaa tgcctcagga agcccagaaa atccaatctg atttgacaag 4500 tcatgagatc agtttagaag aaatgaagaa acataatcag gggaaggagg ctgcccaaag 4560 agtcctgtct cagattgatg ttgcacagaa aaaattacaa gatgtctcca tgaagtttcg 4620 attattccag aaaccagcca attttgagca gcgtctacaa gaaagtaaga tgattttaga 4680 tgaagtgaag atgcacttgc ctgcattgga aacaaagagt gtggaacagg aagtagtaca 4740 gtcacagcta aatcattgtg tgaacttgta taaaagtctg agtgaagtga agtctgaagt 4800 ggaaatggtg ataaagactg gacgtcagat tgtacagaaa aagcagacgg aaaatcccaa 4860 agaacttgat gaaagagtaa cagctttgaa attgcattat aatgagctgg gagcaaaggt 4920 aacagaaaga aagcaacagt tggagaaatg cttgaaattg tcccgtaaga tgcgaaagga 4980 aatgaatgtc ttgacagaat ggctggcagc tacagatatg gaattgacaa agagatcagc 5040 agttgaagga atgcctagta atttggattc tgaagttgcc tggggaaagg ctactcaaaa 5100 agagattgag aaacagaagg tgcacctgaa gagtatcaca gaggtaggag aggccttgaa 5160 aacagttttg ggcaagaagg agacgttggt ggaagataaa ctcagtcttc tgaatagtaa 5220 ctggatagct gtcacctccc gagcagaaga gtggttaaat cttttgttgg aataccagaa 5280 acacatggaa acttttgacc agaatgtgga ccacatcaca aagtggatca ttcaggctga 5340 cacacttttg gatgaatcag agaaaaagaa accccagcaa aaagaagacg tgcttaagcg 5400 tttaaaggca gaactgaatg acatacgccc aaaggtggac tctacacgtg accaagcagc 5460 aaacttgatg gcaaaccgcg gtgaccactg caggaaatta gtagagcccc aaatctcaga 5520 gctcaaccat cgatttgcag ccatttcaca cagaattaag actggaaagg cctccattcc 5580 tttgaaggaa ttggagcagt ttaactcaga tatacaaaaa ttgcttgaac cactggaggc 5640 tgaaattcag cagggggtga atctgaaaga ggaagacttc aataaagata tgaatgaaga 5700 caatgagggt actgtaaaag aattgttgca aagaggagac aacttacaac aaagaatcac 5760 agatgagaga aagcgagagg aaataaagat aaaacagcag ctgttacaga caaaacataa 5820 tgctctcaag gatttgaggt ctcaaagaag aaaaaaggct ctagaaattt ctcatcagtg 5880 gtatcagtac aagaggcagg ctgatgatct cctgaaatgc ttggatgaca ttgaaaaaaa 5940 attagccagc ctacctgagc ccagagatga aaggaaaata aaggaaattg atcgggaatt 6000 gcagaagaag aaagaggagc tgaatgcagt gcgtaggcaa gctgagggct tgtctgagga 6060 tggggccgca atggcagtgg agccaactca gatccagctc agcaagcgct ggcgggaaat 6120 tgagagcaaa tttgctcagt ttcgaagact caactttgca caaattcaca ctgtccgtga 6180 agaaacgatg atggtgatga ctgaagacat gcctttggaa atttcttatg tgccttctac 6240 ttatttgact gaaatcactc atgtctcaca agccctatta gaagtggaac aacttctcaa 6300 tgctcctgac ctctgtgcta aggactttga agatctcttt aagcaagagg agtctctgaa 6360 gaatataaaa gatagtctac aacaaagctc aggtcggatt gacattattc atagcaagaa 6420 gacagcagca ttgcaaagtg caacgcctgt ggaaagggtg aagctacagg aagctctctc 6480 ccagcttgat ttccaatggg aaaaagttaa caaaatgtac aaggaccgac aagggcgatt 6540 tgacagatct gttgagaaat ggcggcgttt tcattatgat ataaagatat ttaatcagtg 6600 gctaacagaa gctgaacagt ttctcagaaa gacacaaatt cctgagaatt gggaacatgc 6660 taaatacaaa tggtatctta aggaactcca ggatggcatt gggcagcggc aaactgttgt 6720 cagaacattg aatgcaactg gggaagaaat aattcagcaa tcctcaaaaa cagatgccag 6780 tattctacag gaaaaattgg gaagcctgaa tctgcggtgg caggaggtct gcaaacagct 6840 gtcagacaga aaaaagaggc tagaagaaca aaagaatatc ttgtcagaat ttcaaagaga 6900 tttaaatgaa tttgttttat ggttggagga agcagataac attgctagta tcccacttga 6960 acctggaaaa gagcagcaac taaaagaaaa gcttgagcaa gtcaagttac tggtggaaga 7020 gttgcccctg cgccagggaa ttctcaaaca attaaatgaa actggaggac ccgtgcttgt 7080 aagtgctccc ataagcccag aagagcaaga taaacttgaa aataagctca agcagacaaa 7140 tctccagtgg ataaaggttt ccagagcttt acctgagaaa caaggagaaa ttgaagctca 7200 aataaaagac cttgggcagc ttgaaaaaaa gcttgaagac cttgaagagc agttaaatca 7260 tctgctgctg tggttatctc ctattaggaa tcagttggaa atttataacc aaccaaacca 7320 agaaggacca tttgacgttc aggaaactga aatagcagtt caagctaaac aaccggatgt 7380 ggaagagatt ttgtctaaag ggcagcattt gtacaaggaa aaaccagcca ctcagccagt 7440 gaagaggaag ttagaagatc tgagctctga gtggaaggcg gtaaaccgtt tacttcaaga 7500 gctgagggca aagcagcctg acctagctcc tggactgacc actattggag cctctcctac 7560 tcagactgtt actctggtga cacaacctgt ggttactaag gaaactgcca tctccaaact 7620 agaaatgcca tcttccttga tgttggaggt acctgctctg gcagatttca accgggcttg 7680 gacagaactt accgactggc tttctctgct tgatcaagtt ataaaatcac agagggtgat 7740 ggtgggtgac cttgaggata tcaacgagat gatcatcaag cagaaggcaa caatgcagga 7800 tttggaacag aggcgtcccc agttggaaga actcattacc gctgcccaaa atttgaaaaa 7860 caagaccagc aatcaagagg ctagaacaat cattacggat cgaattgaaa gaattcagaa 7920 tcagtgggat gaagtacaag aacaccttca gaaccggagg caacagttga atgaaatgtt 7980 aaaggattca acacaatggc tggaagctaa ggaagaagct gagcaggtct taggacaggc 8040 cagagccaag cttgagtcat ggaaggaggg tccctataca gtagatgcaa tccaaaagaa 8100 aatcacagaa accaagcagt tggccaaaga cctccgccag tggcagacaa atgtagatgt 8160 ggcaaatgac ttggccctga aacttctccg ggattattct gcagatgata ccagaaaagt 8220 ccacatgata acagagaata tcaatgcctc ttggagaagc attcataaaa gggtgagtga 8280 gcgagaggct gctttggaag aaactcatag attactgcaa cagttccccc tggacctgga 8340 aaagtttctt gcctggctta cagaagctga aacaactgcc aatgtcctac aggatgctac 8400 ccgtaaggaa aggctcctag aagactccaa gggagtaaaa gagctgatga aacaatggca 8460 agacctccaa ggtgaaattg aagctcacac agatgtttat cacaacctgg atgaaaacag 8520 ccaaaaaatc ctgagatccc tggaaggttc cgatgatgca gtcctgttac aaagacgttt 8580 ggataacatg aacttcaagt ggagtgaact tcggaaaaag tctctcaaca ttaggtccca 8640 tttggaagcc agttctgacc agtggaagcg tctgcacctt tctctgcagg aacttctggt 8700 gtggctacag ctgaaagatg atgaattaag ccggcaggca cctattggag gcgactttcc 8760 agcagttcag aagcagaacg atgtacatag ggccttcaag agggaattga aaactaaaga 8820 acctgtaatc atgagtactc ttgagactgt acgaatattt ctgacagagc agcctttgga 8880 aggactagag aaactctacc aggagcccag agagctgcct cctgaggaga gagcccagaa 8940 tgtcactcgg cttctacgaa agcaggctga ggaggtcaat actgagtggg aaaaattgaa 9000 cctgcactcc gctgactggc agagaaaaat agatgagacc cttgaaagac tccaggaact 9060 tcaagaggcc acggatgagc tggacctcaa gctgcgccaa gctgaggtga tcaagggatc 9120 ctggcagccc gtgggcgatc tcctcattga ctctctccaa gatcacctcg agaaagtcaa 9180 ggcacttcga ggagaaattg cgcctctgaa agagaacgtg agccacgtca atgaccttgc 9240 tcgccagctt accactttgg gcattcagct ctcaccgtat aacctcagca ctctggaaga 9300 cctgaacacc agatggaagc ttctgcaggt ggccgtcgag gaccgagtca ggcagctgca 9360 tgaagcccac agggactttg gtccagcatc tcagcacttt ctttccacgt ctgtccaggg 9420 tccctgggag agagccatct cgccaaacaa agtgccctac tatatcaacc acgagactca 9480 aacaacttgc tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa 9540 taatgtcaga ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct 9600 ttgcttggat ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa 9660 gcaaaatgac cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga 9720 ccgcctggag caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct 9780 gaactggctg ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt 9840 taaaactggc atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt 9900 caagcaagtg gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca 9960 tgattctatc caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat 10020 tgagccaagt gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc 10080 cctcttccta gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca 10140 cagagtggct gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg 10200 tccaatcatt ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag 10260 ctgctttttt tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata 10320 ttgcactccg actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa 10380 atttcgaacc aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac 10440 tgtcttagag ggggacaaca tggaaactcc cgttactctg atcaacttct ggccagtaga 10500 ttctgcgcct gcctcgtccc ctcagctttc acacgatgat actcattcac gcattgaaca 10560 ttatgctagc aggctagcag aaatggaaaa cagcaatgga tcttatctaa atgatagcat 10620 ctctcctaat gagagcatag atgatgaaca tttgttaatc cagcattact gccaaagttt 10680 gaaccaggac tcccccctga gccagcctcg tagtcctgcc cagatcttga tttccttaga 10740 gagtgaggaa agaggggagc tagagagaat cctagcagat cttgaggaag aaaacaggaa 10800 tctgcaagca gaatatgacc gtctaaagca gcagcacgaa cataaaggcc tgtccccact 10860 gccgtcccct cctgaaatga tgcccacctc tccccagagt ccccgggatg ctgagctcat 10920 tgctgaggcc aagctactgc gtcaacacaa aggccgcctg gaagccagga tgcaaatcct 10980 ggaagaccac aataaacagc tggagtcaca gttacacagg ctaaggcagc tgctggagca 11040 accccaggca gaggccaaag tgaatggcac aacggtgtcc tctccttcta cctctctaca 11100 gaggtccgac agcagtcagc ctatgctgct ccgagtggtt ggcagtcaaa cttcggactc 11160 catgggtgag gaagatcttc tcagtcctcc ccaggacaca agcacagggt tagaggaggt 11220 gatggagcaa ctcaacaact ccttccctag ttcaagagga agaaataccc ctggaaagcc 11280 aatgagagag gacacaatgt aggaagtctt ttccacatgg cagatgattt gggcagagcg 11340 atggagtcct tagtatcagt catgacagat gaagaaggag cagaataaat gttttacaac 11400 tcctgattcc cgcatggttt ttataatatt catacaacaa agaggattag acagtaagag 11460 tttacaagaa ataaatctat atttttgtga agggtagtgg tattatactg tagatttcag 11520 tagtttctaa gtctgttatt gttttgttaa caatggcagg ttttacacgt ctatgcaatt 11580 gtacaaaaaa gttataagaa aactacatgt aaaatcttga tagctaaata acttgccatt 11640 tctttatatg gaacgcattt tgggttgttt aaaaatttat aacagttata aagaaagatt 11700 gtaaactaaa gtgtgcttta taaaaaaaag ttgtttataa aaacccctaa aaacaaaaca 11760 aacacacaca cacacacata cacacacaca cacaaaactt tgaggcagcg cattgttttg 11820 catccttttg gcgtgatatc catatgaaat tcatggcttt ttcttttttt gcatattaaa 11880 gataagactt cctctaccac cacaccaaat gactactaca cactgctcat ttgagaactg 11940 tcagctgagt ggggcaggct tgagttttca tttcatatat ctatatgtct ataagtatat 12000 aaatactata gttatataga taaagagata cgaatttcta tagactgact ttttccattt 12060 tttaaatgtt catgtcacat cctaatagaa agaaattact tctagtcagt catccaggct 12120 tacctgcttg gtctagaatg gatttttccc ggagccggaa gccaggagga aactacacca 12180 cactaaaaca ttgtctacag ctccagatgt ttctcatttt aaacaacttt ccactgacaa 12240 cgaaagtaaa gtaaagtatt ggattttttt aaagggaaca tgtgaatgaa tacacaggac 12300 ttattatatc agagtgagta atcggttggt tggttgattg attgattgat tgatacattc 12360 agcttcctgc tgctagcaat gccacgattt agatttaatg atgcttcagt ggaaatcaat 12420 cagaaggtat tctgaccttg tgaacatcag aaggtatttt ttaactccca agcagtagca 12480 ggacgatgat agggctggag ggctatggat tcccagccca tccctgtgaa ggagtaggcc 12540 actctttaag tgaaggattg gatgattgtt cataatacat aaagttctct gtaattacaa 12600 ctaaattatt atgccctctt ctcacagtca aaaggaactg ggtggtttgg tttttgttgc 12660 ttttttagat ttattgtccc atgtgggatg agtttttaaa tgccacaaga cataatttaa 12720 aataaataaa ctttgggaaa aggtgtaaaa cagtagcccc atcacatttg tgatactgac 12780 aggtatcaac ccagaagccc atgaactgtg tttccatcct ttgcatttct ctgcgagtag 12840 ttccacacag gtttgtaagt aagtaagaaa gaaggcaaat tgattcaaat gttacaaaaa 12900 aacccttctt ggtggattag acaggttaaa tatataaaca aacaaacaaa aattgctcaa 12960 aaaagaggag aaaagctcaa gaggaaaagc taaggactgg taggaaaaag ctttactctt 13020 tcatgccatt ttatttcttt ttgattttta aatcattcat tcaatagata ccaccgtgtg 13080 acctataatt ttgcaaatct gttacctctg acatcaagtg taattagctt ttggagagtg 13140 ggctgacatc aagtgtaatt agcttttgga gagtgggttt tgtccattat taataattaa 13200 ttaattaaca tcaaacacgg cttctcatgc tatttctacc tcactttggt tttggggtgt 13260 tcctgataat tgtgcacacc tgagttcaca gcttcaccac ttgtccattg cgttattttc 13320 tttttccttt ataattcttt ctttttcctt cataattttc aaaagaaaac ccaaagctct 13380 aaggtaacaa attaccaaat tacatgaaga tttggttttt gtcttgcatt tttttccttt 13440 atgtgacgct ggaccttttc tttacccaag gatttttaaa actcagattt aaaacaaggg 13500 gttactttac atcctactaa gaagtttaag taagtaagtt tcattctaaa atcagaggta 13560 aatagagtgc ataaataatt ttgttttaat ctttttgttt ttcttttaga cacattagct 13620 ctggagtgag tctgtcataa tatttgaaca aaaattgaga gctttattgc tgcattttaa 13680 gcataattaa tttggacatt atttcgtgtt gtgttcttta taaccaccaa gtattaaact 13740 gtaaatcata atgtaactga agcataaaca tcacatggca tgttttgtca ttgttttcag 13800 gtactgagtt cttacttgag tatcataata tattgtgttt taacaccaac actgtaacat 13860 ttacgaatta tttttttaaa cttcagtttt actgcatttt cacaacatat cagacttcac 13920 caaatatatg ccttactatt gtattatagt actgctttac tgtgtatctc aataaagcac 13980 gcagttatgt tac 13993 <210> 9 <211> 3685 <212> PRT <213> Homo sapiens <400> 9 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser 1775 1780 1785 Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln 1790 1795 1800 Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu 1805 1810 1815 Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn 1820 1825 1830 Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys 1835 1840 1845 Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp 1850 1855 1860 Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln 1865 1870 1875 Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu 1880 1885 1890 Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp 1895 1900 1905 Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys 1910 1915 1920 Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu 1925 1930 1935 Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser 1940 1945 1950 Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg 1955 1960 1965 Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met 1970 1975 1980 Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser 1985 1990 1995 Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu 2000 2005 2010 Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe 2015 2020 2025 Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp 2030 2035 2040 Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys 2045 2050 2055 Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 2060 2065 2070 Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 2075 2080 2085 Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 2090 2095 2100 Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 2105 2110 2115 Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro 2120 2125 2130 Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu 2135 2140 2145 Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 2150 2155 2160 Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala 2165 2170 2175 Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln 2180 2185 2190 Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu 2195 2200 2205 Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe 2210 2215 2220 Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu 2225 2230 2235 Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val 2240 2245 2250 Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys 2255 2260 2265 Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile 2270 2275 2280 Ser Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr 2285 2290 2295 Asn Leu Gln Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln 2300 2305 2310 Gly Glu Ile Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys 2315 2320 2325 Lys Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp 2330 2335 2340 Leu Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn 2345 2350 2355 Gln Glu Gly Pro Phe Asp Val Gln Glu Thr Glu Ile Ala Val Gln 2360 2365 2370 Ala Lys Gln Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His 2375 2380 2385 Leu Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu 2390 2395 2400 Glu Asp Leu Ser Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln 2405 2410 2415 Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr 2420 2425 2430 Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro 2435 2440 2445 Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser 2450 2455 2460 Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala 2465 2470 2475 Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile 2480 2485 2490 Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 2495 2500 2505 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg 2510 2515 2520 Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys 2525 2530 2535 Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg 2540 2545 2550 Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu 2555 2560 2565 Gln Asn Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr 2570 2575 2580 Gln Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln 2585 2590 2595 Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val 2600 2605 2610 Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys 2615 2620 2625 Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu 2630 2635 2640 Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys 2645 2650 2655 Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile 2660 2665 2670 His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His 2675 2680 2685 Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala 2690 2695 2700 Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala 2705 2710 2715 Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu 2720 2725 2730 Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 2735 2740 2745 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu 2750 2755 2760 Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg 2765 2770 2775 Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser 2780 2785 2790 Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys 2795 2800 2805 Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu 2810 2815 2820 Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe 2825 2830 2835 Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg 2840 2845 2850 Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr 2855 2860 2865 Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 2870 2875 2880 Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln 2885 2890 2895 Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr 2900 2905 2910 Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys 2915 2920 2925 Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr 2930 2935 2940 Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly 2945 2950 2955 Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp 2960 2965 2970 His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 2975 2980 2985 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 2990 2995 3000 Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 3005 3010 3015 Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 3020 3025 3030 Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala 3035 3040 3045 Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg 3050 3055 3060 Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 3065 3070 3075 Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln 3080 3085 3090 Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr 3095 3100 3105 Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu 3110 3115 3120 Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu 3125 3130 3135 Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys 3140 3145 3150 Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu 3155 3160 3165 Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu 3170 3175 3180 Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser 3185 3190 3195 Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp 3200 3205 3210 Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 3215 3220 3225 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln 3230 3235 3240 Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn 3245 3250 3255 Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys 3260 3265 3270 Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu 3275 3280 3285 Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala 3290 3295 3300 Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu 3305 3310 3315 Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn 3320 3325 3330 Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys 3335 3340 3345 Gly His Lys Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr 3350 3355 3360 Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn 3365 3370 3375 Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly 3380 3385 3390 Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr 3395 3400 3405 Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala 3410 3415 3420 Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu 3425 3430 3435 His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser 3440 3445 3450 Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu 3455 3460 3465 His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser 3470 3475 3480 Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu 3485 3490 3495 Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu 3500 3505 3510 Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys 3515 3520 3525 Gln Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro 3530 3535 3540 Glu Met Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu 3545 3550 3555 Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu 3560 3565 3570 Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser 3575 3580 3585 Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu 3590 3595 3600 Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr Ser Leu 3605 3610 3615 Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val Val Gly 3620 3625 3630 Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu Ser Pro 3635 3640 3645 Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln Leu 3650 3655 3660 Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys 3665 3670 3675 Pro Met Arg Glu Asp Thr Met 3680 3685 <210> 10 <211> 14000 <212> DNA <213> Homo sapiens <400> 10 atgctgtctg tgaagctgaa tctgtgagaa cacctcacta ttcacggcaa ccggagtgga 60 agaaacaggt gcaaaaagat tgtgtgtttg tctgcttttg tgaggctggt cagagattct 120 gtgcctgctt tatctgtgct tggctatgac tctacctcca ggtttaccat accccataga 180 atgtgtaaga gaaaagtacc aacagggaaa tcagcaaaaa gctttcctat gaaggtgtgt 240 agccagcctc cgcagaattt gaaatgtctg aggtctcatc tgatgaaaga gaagatgttc 300 aaaagaaaac attcacaaaa tgggtaaatg cacaattttc taagtttggg aagcagcata 360 ttgagaacct cttcagtgac ctacaggatg ggaggcgcct cctagacctc ctcgaaggcc 420 tgacagggca aaaactgcca aaagaaaaag gatccacaag agttcatgcc ctgaacaatg 480 tcaacaaggc actgcgggtt ttgcagaaca ataatgttga tttagtgaat attggaagta 540 ctgacatcgt agatggaaat cataaactga ctcttggttt gatttggaat ataatcctcc 600 actggcaggt caaaaatgta atgaaaaata tcatggctgg attgcaacaa accaacagtg 660 aaaagattct cctgagctgg gtccgacaat caactcgtaa ttatccacag gttaatgtaa 720 tcaacttcac caccagctgg tctgatggcc tggctttgaa tgctctcatc catagtcata 780 ggccagacct atttgactgg aatagtgtgg tttgccagca gtcagccaca caacgactgg 840 aacatgcatt caacatcgcc agatatcaat taggcataga gaaactactc gatcctgaag 900 atgttgatac cacctatcca gataagaagt ccatcttaat gtacatcaca tcactcttcc 960 aagttttgcc tcaacaagtg agcattgaag ccatccagga agtggaaatg ttgccaaggc 1020 cacctaaagt gactaaagaa gaacattttc agttacatca tcaaatgcac tattctcaac 1080 agatcacggt cagtctagca cagggatatg agagaacttc ttcccctaag cctcgattca 1140 agagctatgc ctacacacag gctgcttatg tcaccacctc tgaccctaca cggagcccat 1200 ttccttcaca gcatttggaa gctcctgaag acaagtcatt tggcagttca ttgatggaga 1260 gtgaagtaaa cctggaccgt tatcaaacag ctttagaaga agtattatcg tggcttcttt 1320 ctgctgagga cacattgcaa gcacaaggag agatttctaa tgatgtggaa gtggtgaaag 1380 accagtttca tactcatgag gggtacatga tggatttgac agcccatcag ggccgggttg 1440 gtaatattct acaattggga agtaagctga ttggaacagg aaaattatca gaagatgaag 1500 aaactgaagt acaagagcag atgaatctcc taaattcaag atgggaatgc ctcagggtag 1560 ctagcatgga aaaacaaagc aatttacata gagttttaat ggatctccag aatcagaaac 1620 tgaaagagtt gaatgactgg ctaacaaaaa cagaagaaag aacaaggaaa atggaggaag 1680 agcctcttgg acctgatctt gaagacctaa aacgccaagt acaacaacat aaggtgcttc 1740 aagaagatct agaacaagaa caagtcaggg tcaattctct cactcacatg gtggtggtag 1800 ttgatgaatc tagtggagat cacgcaactg ctgctttgga agaacaactt aaggtattgg 1860 gagatcgatg ggcaaacatc tgtagatgga cagaagaccg ctgggttctt ttacaagaca 1920 tccttctcaa atggcaacgt cttactgaag aacagtgcct ttttagtgca tggctttcag 1980 aaaaagaaga tgcagtgaac aagattcaca caactggctt taaagatcaa aatgaaatgt 2040 tatcaagtct tcaaaaactg gccgttttaa aagcggatct agaaaagaaa aagcaatcca 2100 tgggcaaact gtattcactc aaacaagatc ttctttcaac actgaagaat aagtcagtga 2160 cccagaagac ggaagcatgg ctggataact ttgcccggtg ttgggataat ttagtccaaa 2220 aacttgaaaa gagtacagca cagatttcac aggctgtcac caccactcag ccatcactaa 2280 cacagacaac tgtaatggaa acagtaacta cggtgaccac aagggaacag atcctggtaa 2340 agcatgctca agaggaactt ccaccaccac ctccccaaaa gaagaggcag attactgtgg 2400 attctgaaat taggaaaagg ttggatgttg atataactga acttcacagc tggattactc 2460 gctcagaagc tgtgttgcag agtcctgaat ttgcaatctt tcggaaggaa ggcaacttct 2520 cagacttaaa agaaaaagtc aatgccatag agcgagaaaa agctgagaag ttcagaaaac 2580 tgcaagatgc cagcagatca gctcaggccc tggtggaaca gatggtgaat gagggtgtta 2640 atgcagatag catcaaacaa gcctcagaac aactgaacag ccggtggatc gaattctgcc 2700 agttgctaag tgagagactt aactggctgg agtatcagaa caacatcatc gctttctata 2760 atcagctaca acaattggag cagatgacaa ctactgctga aaactggttg aaaatccaac 2820 ccaccacccc atcagagcca acagcaatta aaagtcagtt aaaaatttgt aaggatgaag 2880 tcaaccggct atcaggtctt caacctcaaa ttgaacgatt aaaaattcaa agcatagccc 2940 tgaaagagaa aggacaagga cccatgttcc tggatgcaga ctttgtggcc tttacaaatc 3000 attttaagca agtcttttct gatgtgcagg ccagagagaa agagctacag acaatttttg 3060 acactttgcc accaatgcgc tatcaggaga ccatgagtgc catcaggaca tgggtccagc 3120 agtcagaaac caaactctcc atacctcaac ttagtgtcac cgactatgaa atcatggagc 3180 agagactcgg ggaattgcag gctttacaaa gttctctgca agagcaacaa agtggcctat 3240 actatctcag caccactgtg aaagagatgt cgaagaaagc gccctctgaa attagccgga 3300 aatatcaatc agaatttgaa gaaattgagg gacgctggaa gaagctctcc tcccagctgg 3360 ttgagcattg tcaaaagcta gaggagcaaa tgaataaact ccgaaaaatt cagaatcaca 3420 tacaaaccct gaagaaatgg atggctgaag ttgatgtttt tctgaaggag gaatggcctg 3480 cccttgggga ttcagaaatt ctaaaaaagc agctgaaaca gtgcagactt ttagtcagtg 3540 atattcagac aattcagccc agtctaaaca gtgtcaatga aggtgggcag aagataaaga 3600 atgaagcaga gccagagttt gcttcgagac ttgagacaga actcaaagaa cttaacactc 3660 agtgggatca catgtgccaa caggtctatg ccagaaagga ggccttgaag ggaggtttgg 3720 agaaaactgt aagcctccag aaagatctat cagagatgca cgaatggatg acacaagctg 3780 aagaagagta tcttgagaga gattttgaat ataaaactcc agatgaatta cagaaagcag 3840 ttgaagagat gaagagagct aaagaagagg cccaacaaaa agaagcgaaa gtgaaactcc 3900 ttactgagtc tgtaaatagt gtcatagctc aagctccacc tgtagcacaa gaggccttaa 3960 aaaaggaact tgaaactcta accaccaact accagtggct ctgcactagg ctgaatggga 4020 aatgcaagac tttggaagaa gtttgggcat gttggcatga gttattgtca tacttggaga 4080 aagcaaacaa gtggctaaat gaagtagaat ttaaacttaa aaccactgaa aacattcctg 4140 gcggagctga ggaaatctct gaggtgctag attcacttga aaatttgatg cgacattcag 4200 aggataaccc aaatcagatt cgcatattgg cacagaccct aacagatggc ggagtcatgg 4260 atgagctaat caatgaggaa cttgagacat ttaattctcg ttggagggaa ctacatgaag 4320 aggctgtaag gaggcaaaag ttgcttgaac agagcatcca gtctgcccag gagactgaaa 4380 aatccttaca cttaatccag gagtccctca cattcattga caagcagttg gcagcttata 4440 ttgcagacaa ggtggacgca gctcaaatgc ctcaggaagc ccagaaaatc caatctgatt 4500 tgacaagtca tgagatcagt ttagaagaaa tgaagaaaca taatcagggg aaggaggctg 4560 cccaaagagt cctgtctcag attgatgttg cacagaaaaa attacaagat gtctccatga 4620 agtttcgatt attccagaaa ccagccaatt ttgagcagcg tctacaagaa agtaagatga 4680 ttttagatga agtgaagatg cacttgcctg cattggaaac aaagagtgtg gaacaggaag 4740 tagtacagtc acagctaaat cattgtgtga acttgtataa aagtctgagt gaagtgaagt 4800 ctgaagtgga aatggtgata aagactggac gtcagattgt acagaaaaag cagacggaaa 4860 atcccaaaga acttgatgaa agagtaacag ctttgaaatt gcattataat gagctgggag 4920 caaaggtaac agaaagaaag caacagttgg agaaatgctt gaaattgtcc cgtaagatgc 4980 gaaaggaaat gaatgtcttg acagaatggc tggcagctac agatatggaa ttgacaaaga 5040 gatcagcagt tgaaggaatg cctagtaatt tggattctga agttgcctgg ggaaaggcta 5100 ctcaaaaaga gattgagaaa cagaaggtgc acctgaagag tatcacagag gtaggagagg 5160 ccttgaaaac agttttgggc aagaaggaga cgttggtgga agataaactc agtcttctga 5220 atagtaactg gatagctgtc acctcccgag cagaagagtg gttaaatctt ttgttggaat 5280 accagaaaca catggaaact tttgaccaga atgtggacca catcacaaag tggatcattc 5340 aggctgacac acttttggat gaatcagaga aaaagaaacc ccagcaaaaa gaagacgtgc 5400 ttaagcgttt aaaggcagaa ctgaatgaca tacgcccaaa ggtggactct acacgtgacc 5460 aagcagcaaa cttgatggca aaccgcggtg accactgcag gaaattagta gagccccaaa 5520 tctcagagct caaccatcga tttgcagcca tttcacacag aattaagact ggaaaggcct 5580 ccattccttt gaaggaattg gagcagttta actcagatat acaaaaattg cttgaaccac 5640 tggaggctga aattcagcag ggggtgaatc tgaaagagga agacttcaat aaagatatga 5700 atgaagacaa tgagggtact gtaaaagaat tgttgcaaag aggagacaac ttacaacaaa 5760 gaatcacaga tgagagaaag cgagaggaaa taaagataaa acagcagctg ttacagacaa 5820 aacataatgc tctcaaggat ttgaggtctc aaagaagaaa aaaggctcta gaaatttctc 5880 atcagtggta tcagtacaag aggcaggctg atgatctcct gaaatgcttg gatgacattg 5940 aaaaaaaatt agccagccta cctgagccca gagatgaaag gaaaataaag gaaattgatc 6000 gggaattgca gaagaagaaa gaggagctga atgcagtgcg taggcaagct gagggcttgt 6060 ctgaggatgg ggccgcaatg gcagtggagc caactcagat ccagctcagc aagcgctggc 6120 gggaaattga gagcaaattt gctcagtttc gaagactcaa ctttgcacaa attcacactg 6180 tccgtgaaga aacgatgatg gtgatgactg aagacatgcc tttggaaatt tcttatgtgc 6240 cttctactta tttgactgaa atcactcatg tctcacaagc cctattagaa gtggaacaac 6300 ttctcaatgc tcctgacctc tgtgctaagg actttgaaga tctctttaag caagaggagt 6360 ctctgaagaa tataaaagat agtctacaac aaagctcagg tcggattgac attattcata 6420 gcaagaagac agcagcattg caaagtgcaa cgcctgtgga aagggtgaag ctacaggaag 6480 ctctctccca gcttgatttc caatgggaaa aagttaacaa aatgtacaag gaccgacaag 6540 ggcgatttga cagatctgtt gagaaatggc ggcgttttca ttatgatata aagatattta 6600 atcagtggct aacagaagct gaacagtttc tcagaaagac acaaattcct gagaattggg 6660 aacatgctaa atacaaatgg tatcttaagg aactccagga tggcattggg cagcggcaaa 6720 ctgttgtcag aacattgaat gcaactgggg aagaaataat tcagcaatcc tcaaaaacag 6780 atgccagtat tctacaggaa aaattgggaa gcctgaatct gcggtggcag gaggtctgca 6840 aacagctgtc agacagaaaa aagaggctag aagaacaaaa gaatatcttg tcagaatttc 6900 aaagagattt aaatgaattt gttttatggt tggaggaagc agataacatt gctagtatcc 6960 cacttgaacc tggaaaagag cagcaactaa aagaaaagct tgagcaagtc aagttactgg 7020 tggaagagtt gcccctgcgc cagggaattc tcaaacaatt aaatgaaact ggaggacccg 7080 tgcttgtaag tgctcccata agcccagaag agcaagataa acttgaaaat aagctcaagc 7140 agacaaatct ccagtggata aaggtttcca gagctttacc tgagaaacaa ggagaaattg 7200 aagctcaaat aaaagacctt gggcagcttg aaaaaaagct tgaagacctt gaagagcagt 7260 taaatcatct gctgctgtgg ttatctccta ttaggaatca gttggaaatt tataaccaac 7320 caaaccaaga aggaccattt gacgttcagg aaactgaaat agcagttcaa gctaaacaac 7380 cggatgtgga agagattttg tctaaagggc agcatttgta caaggaaaaa ccagccactc 7440 agccagtgaa gaggaagtta gaagatctga gctctgagtg gaaggcggta aaccgtttac 7500 ttcaagagct gagggcaaag cagcctgacc tagctcctgg actgaccact attggagcct 7560 ctcctactca gactgttact ctggtgacac aacctgtggt tactaaggaa actgccatct 7620 ccaaactaga aatgccatct tccttgatgt tggaggtacc tgctctggca gatttcaacc 7680 gggcttggac agaacttacc gactggcttt ctctgcttga tcaagttata aaatcacaga 7740 gggtgatggt gggtgacctt gaggatatca acgagatgat catcaagcag aaggcaacaa 7800 tgcaggattt ggaacagagg cgtccccagt tggaagaact cattaccgct gcccaaaatt 7860 tgaaaaacaa gaccagcaat caagaggcta gaacaatcat tacggatcga attgaaagaa 7920 ttcagaatca gtgggatgaa gtacaagaac accttcagaa ccggaggcaa cagttgaatg 7980 aaatgttaaa ggattcaaca caatggctgg aagctaagga agaagctgag caggtcttag 8040 gacaggccag agccaagctt gagtcatgga aggagggtcc ctatacagta gatgcaatcc 8100 aaaagaaaat cacagaaacc aagcagttgg ccaaagacct ccgccagtgg cagacaaatg 8160 tagatgtggc aaatgacttg gccctgaaac ttctccggga ttattctgca gatgatacca 8220 gaaaagtcca catgataaca gagaatatca atgcctcttg gagaagcatt cataaaaggg 8280 tgagtgagcg agaggctgct ttggaagaaa ctcatagatt actgcaacag ttccccctgg 8340 acctggaaaa gtttcttgcc tggcttacag aagctgaaac aactgccaat gtcctacagg 8400 atgctacccg taaggaaagg ctcctagaag actccaaggg agtaaaagag ctgatgaaac 8460 aatggcaaga cctccaaggt gaaattgaag ctcacacaga tgtttatcac aacctggatg 8520 aaaacagcca aaaaatcctg agatccctgg aaggttccga tgatgcagtc ctgttacaaa 8580 gacgtttgga taacatgaac ttcaagtgga gtgaacttcg gaaaaagtct ctcaacatta 8640 ggtcccattt ggaagccagt tctgaccagt ggaagcgtct gcacctttct ctgcaggaac 8700 ttctggtgtg gctacagctg aaagatgatg aattaagccg gcaggcacct attggaggcg 8760 actttccagc agttcagaag cagaacgatg tacatagggc cttcaagagg gaattgaaaa 8820 ctaaagaacc tgtaatcatg agtactcttg agactgtacg aatatttctg acagagcagc 8880 ctttggaagg actagagaaa ctctaccagg agcccagaga gctgcctcct gaggagagag 8940 cccagaatgt cactcggctt ctacgaaagc aggctgagga ggtcaatact gagtgggaaa 9000 aattgaacct gcactccgct gactggcaga gaaaaataga tgagaccctt gaaagactcc 9060 aggaacttca agaggccacg gatgagctgg acctcaagct gcgccaagct gaggtgatca 9120 agggatcctg gcagcccgtg ggcgatctcc tcattgactc tctccaagat cacctcgaga 9180 aagtcaaggc acttcgagga gaaattgcgc ctctgaaaga gaacgtgagc cacgtcaatg 9240 accttgctcg ccagcttacc actttgggca ttcagctctc accgtataac ctcagcactc 9300 tggaagacct gaacaccaga tggaagcttc tgcaggtggc cgtcgaggac cgagtcaggc 9360 agctgcatga agcccacagg gactttggtc cagcatctca gcactttctt tccacgtctg 9420 tccagggtcc ctgggagaga gccatctcgc caaacaaagt gccctactat atcaaccacg 9480 agactcaaac aacttgctgg gaccatccca aaatgacaga gctctaccag tctttagctg 9540 acctgaataa tgtcagattc tcagcttata ggactgccat gaaactccga agactgcaga 9600 aggccctttg cttggatctc ttgagcctgt cagctgcatg tgatgccttg gaccagcaca 9660 acctcaagca aaatgaccag cccatggata tcctgcagat tattaattgt ttgaccacta 9720 tttatgaccg cctggagcaa gagcacaaca atttggtcaa cgtccctctc tgcgtggata 9780 tgtgtctgaa ctggctgctg aatgtttatg atacgggacg aacagggagg atccgtgtcc 9840 tgtcttttaa aactggcatc atttccctgt gtaaagcaca tttggaagac aagtacagat 9900 accttttcaa gcaagtggca agttcaacag gattttgtga ccagcgcagg ctgggcctcc 9960 ttctgcatga ttctatccaa attccaagac agttgggtga agttgcatcc tttgggggca 10020 gtaacattga gccaagtgtc cggagctgct tccaatttgc taataataag ccagagatcg 10080 aagcggccct cttcctagac tggatgagac tggaacccca gtccatggtg tggctgcccg 10140 tcctgcacag agtggctgct gcagaaactg ccaagcatca ggccaaatgt aacatctgca 10200 aagagtgtcc aatcattgga ttcaggtaca ggagtctaaa gcactttaat tatgacatct 10260 gccaaagctg ctttttttct ggtcgagttg caaaaggcca taaaatgcac tatcccatgg 10320 tggaatattg cactccgact acatcaggag aagatgttcg agactttgcc aaggtactaa 10380 aaaacaaatt tcgaaccaaa aggtattttg cgaagcatcc ccgaatgggc tacctgccag 10440 tgcagactgt cttagagggg gacaacatgg aaactcccgt tactctgatc aacttctggc 10500 cagtagattc tgcgcctgcc tcgtcccctc agctttcaca cgatgatact cattcacgca 10560 ttgaacatta tgctagcagg ctagcagaaa tggaaaacag caatggatct tatctaaatg 10620 atagcatctc tcctaatgag agcatagatg atgaacattt gttaatccag cattactgcc 10680 aaagtttgaa ccaggactcc cccctgagcc agcctcgtag tcctgcccag atcttgattt 10740 ccttagagag tgaggaaaga ggggagctag agagaatcct agcagatctt gaggaagaaa 10800 acaggaatct gcaagcagaa tatgaccgtc taaagcagca gcacgaacat aaaggcctgt 10860 ccccactgcc gtcccctcct gaaatgatgc ccacctctcc ccagagtccc cgggatgctg 10920 agctcattgc tgaggccaag ctactgcgtc aacacaaagg ccgcctggaa gccaggatgc 10980 aaatcctgga agaccacaat aaacagctgg agtcacagtt acacaggcta aggcagctgc 11040 tggagcaacc ccaggcagag gccaaagtga atggcacaac ggtgtcctct ccttctacct 11100 ctctacagag gtccgacagc agtcagccta tgctgctccg agtggttggc agtcaaactt 11160 cggactccat gggtgaggaa gatcttctca gtcctcccca ggacacaagc acagggttag 11220 aggaggtgat ggagcaactc aacaactcct tccctagttc aagaggaaga aatacccctg 11280 gaaagccaat gagagaggac acaatgtagg aagtcttttc cacatggcag atgatttggg 11340 cagagcgatg gagtccttag tatcagtcat gacagatgaa gaaggagcag aataaatgtt 11400 ttacaactcc tgattcccgc atggttttta taatattcat acaacaaaga ggattagaca 11460 gtaagagttt acaagaaata aatctatatt tttgtgaagg gtagtggtat tatactgtag 11520 atttcagtag tttctaagtc tgttattgtt ttgttaacaa tggcaggttt tacacgtcta 11580 tgcaattgta caaaaaagtt ataagaaaac tacatgtaaa atcttgatag ctaaataact 11640 tgccatttct ttatatggaa cgcattttgg gttgtttaaa aatttataac agttataaag 11700 aaagattgta aactaaagtg tgctttataa aaaaaagttg tttataaaaa cccctaaaaa 11760 caaaacaaac acacacacac acacatacac acacacacac aaaactttga ggcagcgcat 11820 tgttttgcat ccttttggcg tgatatccat atgaaattca tggctttttc tttttttgca 11880 tattaaagat aagacttcct ctaccaccac accaaatgac tactacacac tgctcatttg 11940 agaactgtca gctgagtggg gcaggcttga gttttcattt catatatcta tatgtctata 12000 agtatataaa tactatagtt atatagataa agagatacga atttctatag actgactttt 12060 tccatttttt aaatgttcat gtcacatcct aatagaaaga aattacttct agtcagtcat 12120 ccaggcttac ctgcttggtc tagaatggat ttttcccgga gccggaagcc aggaggaaac 12180 tacaccacac taaaacattg tctacagctc cagatgtttc tcattttaaa caactttcca 12240 ctgacaacga aagtaaagta aagtattgga tttttttaaa gggaacatgt gaatgaatac 12300 acaggactta ttatatcaga gtgagtaatc ggttggttgg ttgattgatt gattgattga 12360 tacattcagc ttcctgctgc tagcaatgcc acgatttaga tttaatgatg cttcagtgga 12420 aatcaatcag aaggtattct gaccttgtga acatcagaag gtatttttta actcccaagc 12480 agtagcagga cgatgatagg gctggagggc tatggattcc cagcccatcc ctgtgaagga 12540 gtaggccact ctttaagtga aggattggat gattgttcat aatacataaa gttctctgta 12600 attacaacta aattattatg ccctcttctc acagtcaaaa ggaactgggt ggtttggttt 12660 ttgttgcttt tttagattta ttgtcccatg tgggatgagt ttttaaatgc cacaagacat 12720 aatttaaaat aaataaactt tgggaaaagg tgtaaaacag tagccccatc acatttgtga 12780 tactgacagg tatcaaccca gaagcccatg aactgtgttt ccatcctttg catttctctg 12840 cgagtagttc cacacaggtt tgtaagtaag taagaaagaa ggcaaattga ttcaaatgtt 12900 acaaaaaaac ccttcttggt ggattagaca ggttaaatat ataaacaaac aaacaaaaat 12960 tgctcaaaaa agaggagaaa agctcaagag gaaaagctaa ggactggtag gaaaaagctt 13020 tactctttca tgccatttta tttctttttg atttttaaat cattcattca atagatacca 13080 ccgtgtgacc tataattttg caaatctgtt acctctgaca tcaagtgtaa ttagcttttg 13140 gagagtgggc tgacatcaag tgtaattagc ttttggagag tgggttttgt ccattattaa 13200 taattaatta attaacatca aacacggctt ctcatgctat ttctacctca ctttggtttt 13260 ggggtgttcc tgataattgt gcacacctga gttcacagct tcaccacttg tccattgcgt 13320 tattttcttt ttcctttata attctttctt tttccttcat aattttcaaa agaaaaccca 13380 aagctctaag gtaacaaatt accaaattac atgaagattt ggtttttgtc ttgcattttt 13440 ttcctttatg tgacgctgga ccttttcttt acccaaggat ttttaaaact cagatttaaa 13500 acaaggggtt actttacatc ctactaagaa gtttaagtaa gtaagtttca ttctaaaatc 13560 agaggtaaat agagtgcata aataattttg ttttaatctt tttgtttttc ttttagacac 13620 attagctctg gagtgagtct gtcataatat ttgaacaaaa attgagagct ttattgctgc 13680 attttaagca taattaattt ggacattatt tcgtgttgtg ttctttataa ccaccaagta 13740 ttaaactgta aatcataatg taactgaagc ataaacatca catggcatgt tttgtcattg 13800 ttttcaggta ctgagttctt acttgagtat cataatatat tgtgttttaa caccaacact 13860 gtaacattta cgaattattt ttttaaactt cagttttact gcattttcac aacatatcag 13920 acttcaccaa atatatgcct tactattgta ttatagtact gctttactgt gtatctcaat 13980 aaagcacgca gttatgttac 14000 <210> 11 <211> 3681 <212> PRT <213> Homo sapiens <400> 11 Met Ser Glu Val Ser Ser Asp Glu Arg Glu Asp Val Gln Lys Lys Thr 1 5 10 15 Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe Gly Lys Gln His 20 25 30 Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg Arg Leu Leu Asp 35 40 45 Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys Glu Lys Gly Ser 50 55 60 Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala Leu Arg Val Leu 65 70 75 80 Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser Thr Asp Ile Val 85 90 95 Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp Asn Ile Ile Leu 100 105 110 His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met Ala Gly Leu Gln 115 120 125 Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val Arg Gln Ser Thr 130 135 140 Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr Thr Ser Trp Ser 145 150 155 160 Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His Arg Pro Asp Leu 165 170 175 Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala Thr Gln Arg Leu 180 185 190 Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly Ile Glu Lys Leu 195 200 205 Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp Lys Lys Ser Ile 210 215 220 Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro Gln Gln Val Ser 225 230 235 240 Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg Pro Pro Lys Val 245 250 255 Thr Lys Glu Glu His Phe Gln Leu His His Gln Met His Tyr Ser Gln 260 265 270 Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg Thr Ser Ser Pro 275 280 285 Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala Ala Tyr Val Thr 290 295 300 Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln His Leu Glu Ala 305 310 315 320 Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu Ser Glu Val Asn 325 330 335 Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu Ser Trp Leu Leu 340 345 350 Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile Ser Asn Asp Val 355 360 365 Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly Tyr Met Met Asp 370 375 380 Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu Gln Leu Gly Ser 385 390 395 400 Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu Glu Thr Glu Val 405 410 415 Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu Cys Leu Arg Val 420 425 430 Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val Leu Met Asp Leu 435 440 445 Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu Thr Lys Thr Glu 450 455 460 Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly Pro Asp Leu Glu 465 470 475 480 Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu Gln Glu Asp Leu 485 490 495 Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His Met Val Val Val 500 505 510 Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala Leu Glu Glu Gln 515 520 525 Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys Arg Trp Thr Glu 530 535 540 Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys Trp Gln Arg Leu 545 550 555 560 Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser Glu Lys Glu Asp 565 570 575 Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp Gln Asn Glu Met 580 585 590 Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala Asp Leu Glu Lys 595 600 605 Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys Gln Asp Leu Leu 610 615 620 Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr Glu Ala Trp Leu 625 630 635 640 Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln Lys Leu Glu Lys 645 650 655 Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr Gln Pro Ser Leu 660 665 670 Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val Thr Thr Arg Glu 675 680 685 Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro Pro Pro Pro Pro 690 695 700 Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile Arg Lys Arg Leu 705 710 715 720 Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr Arg Ser Glu Ala 725 730 735 Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys Glu Gly Asn Phe 740 745 750 Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg Glu Lys Ala Glu 755 760 765 Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala Gln Ala Leu Val 770 775 780 Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser Ile Lys Gln Ala 785 790 795 800 Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys Gln Leu Leu Ser 805 810 815 Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile Ile Ala Phe Tyr 820 825 830 Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr Ala Glu Asn Trp 835 840 845 Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr Ala Ile Lys Ser 850 855 860 Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu Ser Gly Leu Gln 865 870 875 880 Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala Leu Lys Glu Lys 885 890 895 Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val Ala Phe Thr Asn 900 905 910 His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg Glu Lys Glu Leu 915 920 925 Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr Gln Glu Thr Met 930 935 940 Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr Lys Leu Ser Ile 945 950 955 960 Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu Gln Arg Leu Gly 965 970 975 Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln Gln Ser Gly Leu 980 985 990 Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys Lys Ala Pro Ser 995 1000 1005 Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu Glu Ile Glu Gly 1010 1015 1020 Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu His Cys Gln Lys 1025 1030 1035 Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile Gln Asn His Ile 1040 1045 1050 Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp Val Phe Leu Lys 1055 1060 1065 Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile Leu Lys Lys Gln 1070 1075 1080 Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile Gln Thr Ile Gln 1085 1090 1095 Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln Lys Ile Lys Asn 1100 1105 1110 Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu Thr Glu Leu Lys 1115 1120 1125 Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln Gln Val Tyr Ala 1130 1135 1140 Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys Thr Val Ser Leu 1145 1150 1155 Gln Lys Asp Leu Ser Glu Met His Glu Trp Met Thr Gln Ala Glu 1160 1165 1170 Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys Thr Pro Asp Glu 1175 1180 1185 Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala Lys Glu Glu Ala 1190 1195 1200 Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr Glu Ser Val Asn 1205 1210 1215 Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln Glu Ala Leu Lys 1220 1225 1230 Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln Trp Leu Cys Thr 1235 1240 1245 Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu Val Trp Ala Cys 1250 1255 1260 Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala Asn Lys Trp Leu 1265 1270 1275 Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu Asn Ile Pro Gly 1280 1285 1290 Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser Leu Glu Asn Leu 1295 1300 1305 Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile Arg Ile Leu Ala 1310 1315 1320 Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu Leu Ile Asn Glu 1325 1330 1335 Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu Leu His Glu Glu 1340 1345 1350 Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser Ile Gln Ser Ala 1355 1360 1365 Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln Glu Ser Leu Thr 1370 1375 1380 Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala Asp Lys Val Asp 1385 1390 1395 Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile Gln Ser Asp Leu 1400 1405 1410 Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys Lys His Asn Gln 1415 1420 1425 Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln Ile Asp Val Ala 1430 1435 1440 Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe Arg Leu Phe Gln 1445 1450 1455 Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu Ser Lys Met Ile 1460 1465 1470 Leu Asp Glu Val Lys Met His Leu Pro Ala Leu Glu Thr Lys Ser 1475 1480 1485 Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn His Cys Val Asn 1490 1495 1500 Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu Val Glu Met Val 1505 1510 1515 Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys Gln Thr Glu Asn 1520 1525 1530 Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu Lys Leu His Tyr 1535 1540 1545 Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys Gln Gln Leu Glu 1550 1555 1560 Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys Glu Met Asn Val 1565 1570 1575 Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu Leu Thr Lys Arg 1580 1585 1590 Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp Ser Glu Val Ala 1595 1600 1605 Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys Gln Lys Val His 1610 1615 1620 Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu Lys Thr Val Leu 1625 1630 1635 Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu Ser Leu Leu Asn 1640 1645 1650 Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu Glu Trp Leu Asn 1655 1660 1665 Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr Phe Asp Gln Asn 1670 1675 1680 Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala Asp Thr Leu Leu 1685 1690 1695 Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys Glu Asp Val Leu 1700 1705 1710 Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg Pro Lys Val Asp 1715 1720 1725 Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala Asn Arg Gly Asp 1730 1735 1740 His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser Glu Leu Asn His 1745 1750 1755 Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr Gly Lys Ala Ser 1760 1765 1770 Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser Asp Ile Gln Lys 1775 1780 1785 Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln Gly Val Asn Leu 1790 1795 1800 Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu Asp Asn Glu Gly 1805 1810 1815 Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn Leu Gln Gln Arg 1820 1825 1830 Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys Ile Lys Gln Gln 1835 1840 1845 Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp Leu Arg Ser Gln 1850 1855 1860 Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln Trp Tyr Gln Tyr 1865 1870 1875 Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu Asp Asp Ile Glu 1880 1885 1890 Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp Glu Arg Lys Ile 1895 1900 1905 Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys Glu Glu Leu Asn 1910 1915 1920 Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu Asp Gly Ala Ala 1925 1930 1935 Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser Lys Arg Trp Arg 1940 1945 1950 Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg Leu Asn Phe Ala 1955 1960 1965 Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu 1970 1975 1980 Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr 1985 1990 1995 Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu 2000 2005 2010 Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe 2015 2020 2025 Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln 2030 2035 2040 Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala 2045 2050 2055 Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln Glu Ala 2060 2065 2070 Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr 2075 2080 2085 Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg 2090 2095 2100 Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu 2105 2110 2115 Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp Glu 2120 2125 2130 His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile 2135 2140 2145 Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu 2150 2155 2160 Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln 2165 2170 2175 Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys 2180 2185 2190 Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Lys Asn Ile 2195 2200 2205 Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe Val Leu Trp Leu 2210 2215 2220 Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu Glu Pro Gly Lys 2225 2230 2235 Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val Lys Leu Leu Val 2240 2245 2250 Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys Gln Leu Asn Glu 2255 2260 2265 Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile Ser Pro Glu Glu 2270 2275 2280 Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr Asn Leu Gln Trp 2285 2290 2295 Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln Gly Glu Ile Glu 2300 2305 2310 Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys Lys Leu Glu Asp 2315 2320 2325 Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp Leu Ser Pro Ile 2330 2335 2340 Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn Gln Glu Gly Pro 2345 2350 2355 Phe Asp Val Gln Glu Thr Glu Ile Ala Val Gln Ala Lys Gln Pro 2360 2365 2370 Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His Leu Tyr Lys Glu 2375 2380 2385 Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu Glu Asp Leu Ser 2390 2395 2400 Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln Glu Leu Arg Ala 2405 2410 2415 Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser 2420 2425 2430 Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro Val Val Thr Lys 2435 2440 2445 Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser Ser Leu Met Leu 2450 2455 2460 Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala Trp Thr Glu Leu 2465 2470 2475 Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile Lys Ser Gln Arg 2480 2485 2490 Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu Met Ile Ile Lys 2495 2500 2505 Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg Arg Pro Gln Leu 2510 2515 2520 Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn Lys Thr Ser 2525 2530 2535 Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg Ile 2540 2545 2550 Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg 2555 2560 2565 Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu 2570 2575 2580 Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys 2585 2590 2595 Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln 2600 2605 2610 Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln 2615 2620 2625 Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu 2630 2635 2640 Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys Val His Met Ile 2645 2650 2655 Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile His Lys Arg Val 2660 2665 2670 Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His Arg Leu Leu Gln 2675 2680 2685 Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp Leu Thr Glu 2690 2695 2700 Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala Thr Arg Lys Glu 2705 2710 2715 Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu Leu Met Lys Gln 2720 2725 2730 Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr 2735 2740 2745 His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu 2750 2755 2760 Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met 2765 2770 2775 Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg 2780 2785 2790 Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu 2795 2800 2805 Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu 2810 2815 2820 Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln 2825 2830 2835 Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr 2840 2845 2850 Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe 2855 2860 2865 Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu 2870 2875 2880 Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn Val Thr Arg 2885 2890 2895 Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr Glu Trp Glu Lys 2900 2905 2910 Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu Thr 2915 2920 2925 Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp 2930 2935 2940 Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro 2945 2950 2955 Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys 2960 2965 2970 Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val 2975 2980 2985 Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile 2990 2995 3000 Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr 3005 3010 3015 Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln 3020 3025 3030 Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe 3035 3040 3045 Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro 3050 3055 3060 Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys 3065 3070 3075 Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp 3080 3085 3090 Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu 3095 3100 3105 Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser 3110 3115 3120 Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp 3125 3130 3135 Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile 3140 3145 3150 Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro 3155 3160 3165 Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp 3170 3175 3180 Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly 3185 3190 3195 Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr 3200 3205 3210 Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg 3215 3220 3225 Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln 3230 3235 3240 Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser 3245 3250 3255 Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu 3260 3265 3270 Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 3275 3280 3285 Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala 3290 3295 3300 Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile 3305 3310 3315 Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys 3320 3325 3330 Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met 3335 3340 3345 His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu 3350 3355 3360 Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr 3365 3370 3375 Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val 3380 3385 3390 Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr Pro Val Thr Leu 3395 3400 3405 Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala Ser Ser Pro Gln 3410 3415 3420 Leu Ser His Asp Asp Thr His Ser Arg Ile Glu His Tyr Ala Ser 3425 3430 3435 Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn Asp 3440 3445 3450 Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu His Leu Leu Ile 3455 3460 3465 Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln 3470 3475 3480 Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu 3485 3490 3495 Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn 3500 3505 3510 Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu 3515 3520 3525 His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro 3530 3535 3540 Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala 3545 3550 3555 Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln 3560 3565 3570 Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg 3575 3580 3585 Leu Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn 3590 3595 3600 Gly Thr Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp 3605 3610 3615 Ser Ser Gln Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser 3620 3625 3630 Asp Ser Met Gly Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr 3635 3640 3645 Ser Thr Gly Leu Glu Glu Val Met Glu Gln Leu Asn Asn Ser Phe 3650 3655 3660 Pro Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys Pro Met Arg Glu 3665 3670 3675 Asp Thr Met 3680 <210> 12 <211> 9771 <212> DNA <213> Homo sapiens <400> 12 taatgagatc aggaggaaca ttcgacctga gaaagacaga ttgcaatgac tgagatgatt 60 ttgctaattt tttttccagc ctatttcctt aatgctgtaa ggaggcaaaa gttgcttgaa 120 cagagcatcc agtctgccca ggagactgaa aaatccttac acttaatcca ggagtccctc 180 acattcattg acaagcagtt ggcagcttat attgcagaca aggtggacgc agctcaaatg 240 cctcaggaag cccagaaaat ccaatctgat ttgacaagtc atgagatcag tttagaagaa 300 atgaagaaac ataatcaggg gaaggaggct gcccaaagag tcctgtctca gattgatgtt 360 gcacagaaaa aattacaaga tgtctccatg aagtttcgat tattccagaa accagccaat 420 tttgagcagc gtctacaaga aagtaagatg attttagatg aagtgaagat gcacttgcct 480 gcattggaaa caaagagtgt ggaacaggaa gtagtacagt cacagctaaa tcattgtgtg 540 aacttgtata aaagtctgag tgaagtgaag tctgaagtgg aaatggtgat aaagactgga 600 cgtcagattg tacagaaaaa gcagacggaa aatcccaaag aacttgatga aagagtaaca 660 gctttgaaat tgcattataa tgagctggga gcaaaggtaa cagaaagaaa gcaacagttg 720 gagaaatgct tgaaattgtc ccgtaagatg cgaaaggaaa tgaatgtctt gacagaatgg 780 ctggcagcta cagatatgga attgacaaag agatcagcag ttgaaggaat gcctagtaat 840 ttggattctg aagttgcctg gggaaaggct actcaaaaag agattgagaa acagaaggtg 900 cacctgaaga gtatcacaga ggtaggagag gccttgaaaa cagttttggg caagaaggag 960 acgttggtgg aagataaact cagtcttctg aatagtaact ggatagctgt cacctcccga 1020 gcagaagagt ggttaaatct tttgttggaa taccagaaac acatggaaac ttttgaccag 1080 aatgtggacc acatcacaaa gtggatcatt caggctgaca cacttttgga tgaatcagag 1140 aaaaagaaac cccagcaaaa agaagacgtg cttaagcgtt taaaggcaga actgaatgac 1200 atacgcccaa aggtggactc tacacgtgac caagcagcaa acttgatggc aaaccgcggt 1260 gaccactgca ggaaattagt agagccccaa atctcagagc tcaaccatcg atttgcagcc 1320 atttcacaca gaattaagac tggaaaggcc tccattcctt tgaaggaatt ggagcagttt 1380 aactcagata tacaaaaatt gcttgaacca ctggaggctg aaattcagca gggggtgaat 1440 ctgaaagagg aagacttcaa taaagatatg aatgaagaca atgagggtac tgtaaaagaa 1500 ttgttgcaaa gaggagacaa cttacaacaa agaatcacag atgagagaaa gcgagaggaa 1560 ataaagataa aacagcagct gttacagaca aaacataatg ctctcaagga tttgaggtct 1620 caaagaagaa aaaaggctct agaaatttct catcagtggt atcagtacaa gaggcaggct 1680 gatgatctcc tgaaatgctt ggatgacatt gaaaaaaaat tagccagcct acctgagccc 1740 agagatgaaa ggaaaataaa ggaaattgat cgggaattgc agaagaagaa agaggagctg 1800 aatgcagtgc gtaggcaagc tgagggcttg tctgaggatg gggccgcaat ggcagtggag 1860 ccaactcaga tccagctcag caagcgctgg cgggaaattg agagcaaatt tgctcagttt 1920 cgaagactca actttgcaca aattcacact gtccgtgaag aaacgatgat ggtgatgact 1980 gaagacatgc ctttggaaat ttcttatgtg ccttctactt atttgactga aatcactcat 2040 gtctcacaag ccctattaga agtggaacaa cttctcaatg ctcctgacct ctgtgctaag 2100 gactttgaag atctctttaa gcaagaggag tctctgaaga atataaaaga tagtctacaa 2160 caaagctcag gtcggattga cattattcat agcaagaaga cagcagcatt gcaaagtgca 2220 acgcctgtgg aaagggtgaa gctacaggaa gctctctccc agcttgattt ccaatgggaa 2280 aaagttaaca aaatgtacaa ggaccgacaa gggcgatttg acagatctgt tgagaaatgg 2340 cggcgttttc attatgatat aaagatattt aatcagtggc taacagaagc tgaacagttt 2400 ctcagaaaga cacaaattcc tgagaattgg gaacatgcta aatacaaatg gtatcttaag 2460 gaactccagg atggcattgg gcagcggcaa actgttgtca gaacattgaa tgcaactggg 2520 gaagaaataa ttcagcaatc ctcaaaaaca gatgccagta ttctacagga aaaattggga 2580 agcctgaatc tgcggtggca ggaggtctgc aaacagctgt cagacagaaa aaagaggcta 2640 gaagaacaaa agaatatctt gtcagaattt caaagagatt taaatgaatt tgttttatgg 2700 ttggaggaag cagataacat tgctagtatc ccacttgaac ctggaaaaga gcagcaacta 2760 aaagaaaagc ttgagcaagt caagttactg gtggaagagt tgcccctgcg ccagggaatt 2820 ctcaaacaat taaatgaaac tggaggaccc gtgcttgtaa gtgctcccat aagcccagaa 2880 gagcaagata aacttgaaaa taagctcaag cagacaaatc tccagtggat aaaggtttcc 2940 agagctttac ctgagaaaca aggagaaatt gaagctcaaa taaaagacct tgggcagctt 3000 gaaaaaaagc ttgaagacct tgaagagcag ttaaatcatc tgctgctgtg gttatctcct 3060 attaggaatc agttggaaat ttataaccaa ccaaaccaag aaggaccatt tgacgttcag 3120 gaaactgaaa tagcagttca agctaaacaa ccggatgtgg aagagatttt gtctaaaggg 3180 cagcatttgt acaaggaaaa accagccact cagccagtga agaggaagtt agaagatctg 3240 agctctgagt ggaaggcggt aaaccgttta cttcaagagc tgagggcaaa gcagcctgac 3300 ctagctcctg gactgaccac tattggagcc tctcctactc agactgttac tctggtgaca 3360 caacctgtgg ttactaagga aactgccatc tccaaactag aaatgccatc ttccttgatg 3420 ttggaggtac ctgctctggc agatttcaac cgggcttgga cagaacttac cgactggctt 3480 tctctgcttg atcaagttat aaaatcacag agggtgatgg tgggtgacct tgaggatatc 3540 aacgagatga tcatcaagca gaaggcaaca atgcaggatt tggaacagag gcgtccccag 3600 ttggaagaac tcattaccgc tgcccaaaat ttgaaaaaca agaccagcaa tcaagaggct 3660 agaacaatca ttacggatcg aattgaaaga attcagaatc agtgggatga agtacaagaa 3720 caccttcaga accggaggca acagttgaat gaaatgttaa aggattcaac acaatggctg 3780 gaagctaagg aagaagctga gcaggtctta ggacaggcca gagccaagct tgagtcatgg 3840 aaggagggtc cctatacagt agatgcaatc caaaagaaaa tcacagaaac caagcagttg 3900 gccaaagacc tccgccagtg gcagacaaat gtagatgtgg caaatgactt ggccctgaaa 3960 cttctccggg attattctgc agatgatacc agaaaagtcc acatgataac agagaatatc 4020 aatgcctctt ggagaagcat tcataaaagg gtgagtgagc gagaggctgc tttggaagaa 4080 actcatagat tactgcaaca gttccccctg gacctggaaa agtttcttgc ctggcttaca 4140 gaagctgaaa caactgccaa tgtcctacag gatgctaccc gtaaggaaag gctcctagaa 4200 gactccaagg gagtaaaaga gctgatgaaa caatggcaag acctccaagg tgaaattgaa 4260 gctcacacag atgtttatca caacctggat gaaaacagcc aaaaaatcct gagatccctg 4320 gaaggttccg atgatgcagt cctgttacaa agacgtttgg ataacatgaa cttcaagtgg 4380 agtgaacttc ggaaaaagtc tctcaacatt aggtcccatt tggaagccag ttctgaccag 4440 tggaagcgtc tgcacctttc tctgcaggaa cttctggtgt ggctacagct gaaagatgat 4500 gaattaagcc ggcaggcacc tattggaggc gactttccag cagttcagaa gcagaacgat 4560 gtacataggg ccttcaagag ggaattgaaa actaaagaac ctgtaatcat gagtactctt 4620 gagactgtac gaatatttct gacagagcag cctttggaag gactagagaa actctaccag 4680 gagcccagag agctgcctcc tgaggagaga gcccagaatg tcactcggct tctacgaaag 4740 caggctgagg aggtcaatac tgagtgggaa aaattgaacc tgcactccgc tgactggcag 4800 agaaaaatag atgagaccct tgaaagactc caggaacttc aagaggccac ggatgagctg 4860 gacctcaagc tgcgccaagc tgaggtgatc aagggatcct ggcagcccgt gggcgatctc 4920 ctcattgact ctctccaaga tcacctcgag aaagtcaagg cacttcgagg agaaattgcg 4980 cctctgaaag agaacgtgag ccacgtcaat gaccttgctc gccagcttac cactttgggc 5040 attcagctct caccgtataa cctcagcact ctggaagacc tgaacaccag atggaagctt 5100 ctgcaggtgg ccgtcgagga ccgagtcagg cagctgcatg aagcccacag ggactttggt 5160 ccagcatctc agcactttct ttccacgtct gtccagggtc cctgggagag agccatctcg 5220 ccaaacaaag tgccctacta tatcaaccac gagactcaaa caacttgctg ggaccatccc 5280 aaaatgacag agctctacca gtctttagct gacctgaata atgtcagatt ctcagcttat 5340 aggactgcca tgaaactccg aagactgcag aaggcccttt gcttggatct cttgagcctg 5400 tcagctgcat gtgatgcctt ggaccagcac aacctcaagc aaaatgacca gcccatggat 5460 atcctgcaga ttattaattg tttgaccact atttatgacc gcctggagca agagcacaac 5520 aatttggtca acgtccctct ctgcgtggat atgtgtctga actggctgct gaatgtttat 5580 gatacgggac gaacagggag gatccgtgtc ctgtctttta aaactggcat catttccctg 5640 tgtaaagcac atttggaaga caagtacaga taccttttca agcaagtggc aagttcaaca 5700 ggattttgtg accagcgcag gctgggcctc cttctgcatg attctatcca aattccaaga 5760 cagttgggtg aagttgcatc ctttgggggc agtaacattg agccaagtgt ccggagctgc 5820 ttccaatttg ctaataataa gccagagatc gaagcggccc tcttcctaga ctggatgaga 5880 ctggaacccc agtccatggt gtggctgccc gtcctgcaca gagtggctgc tgcagaaact 5940 gccaagcatc aggccaaatg taacatctgc aaagagtgtc caatcattgg attcaggtac 6000 aggagtctaa agcactttaa ttatgacatc tgccaaagct gctttttttc tggtcgagtt 6060 gcaaaaggcc ataaaatgca ctatcccatg gtggaatatt gcactccgac tacatcagga 6120 gaagatgttc gagactttgc caaggtacta aaaaacaaat ttcgaaccaa aaggtatttt 6180 gcgaagcatc cccgaatggg ctacctgcca gtgcagactg tcttagaggg ggacaacatg 6240 gaaactcccg ttactctgat caacttctgg ccagtagatt ctgcgcctgc ctcgtcccct 6300 cagctttcac acgatgatac tcattcacgc attgaacatt atgctagcag gctagcagaa 6360 atggaaaaca gcaatggatc ttatctaaat gatagcatct ctcctaatga gagcatagat 6420 gatgaacatt tgttaatcca gcattactgc caaagtttga accaggactc ccccctgagc 6480 cagcctcgta gtcctgccca gatcttgatt tccttagaga gtgaggaaag aggggagcta 6540 gagagaatcc tagcagatct tgaggaagaa aacaggaatc tgcaagcaga atatgaccgt 6600 ctaaagcagc agcacgaaca taaaggcctg tccccactgc cgtcccctcc tgaaatgatg 6660 cccacctctc cccagagtcc ccgggatgct gagctcattg ctgaggccaa gctactgcgt 6720 caacacaaag gccgcctgga agccaggatg caaatcctgg aagaccacaa taaacagctg 6780 gagtcacagt tacacaggct aaggcagctg ctggagcaac cccaggcaga ggccaaagtg 6840 aatggcacaa cggtgtcctc tccttctacc tctctacaga ggtccgacag cagtcagcct 6900 atgctgctcc gagtggttgg cagtcaaact tcggactcca tgggtgagga agatcttctc 6960 agtcctcccc aggacacaag cacagggtta gaggaggtga tggagcaact caacaactcc 7020 ttccctagtt caagaggaag aaatacccct ggaaagccaa tgagagagga cacaatgtag 7080 gaagtctttt ccacatggca gatgatttgg gcagagcgat ggagtcctta gtatcagtca 7140 tgacagatga agaaggagca gaataaatgt tttacaactc ctgattcccg catggttttt 7200 ataatattca tacaacaaag aggattagac agtaagagtt tacaagaaat aaatctatat 7260 ttttgtgaag ggtagtggta ttatactgta gatttcagta gtttctaagt ctgttattgt 7320 tttgttaaca atggcaggtt ttacacgtct atgcaattgt acaaaaaagt tataagaaaa 7380 ctacatgtaa aatcttgata gctaaataac ttgccatttc tttatatgga acgcattttg 7440 ggttgtttaa aaatttataa cagttataaa gaaagattgt aaactaaagt gtgctttata 7500 aaaaaaagtt gtttataaaa acccctaaaa acaaaacaaa cacacacaca cacacataca 7560 cacacacaca caaaactttg aggcagcgca ttgttttgca tccttttggc gtgatatcca 7620 tatgaaattc atggcttttt ctttttttgc atattaaaga taagacttcc tctaccacca 7680 caccaaatga ctactacaca ctgctcattt gagaactgtc agctgagtgg ggcaggcttg 7740 agttttcatt tcatatatct atatgtctat aagtatataa atactatagt tatatagata 7800 aagagatacg aatttctata gactgacttt ttccattttt taaatgttca tgtcacatcc 7860 taatagaaag aaattacttc tagtcagtca tccaggctta cctgcttggt ctagaatgga 7920 tttttcccgg agccggaagc caggaggaaa ctacaccaca ctaaaacatt gtctacagct 7980 ccagatgttt ctcattttaa acaactttcc actgacaacg aaagtaaagt aaagtattgg 8040 atttttttaa agggaacatg tgaatgaata cacaggactt attatatcag agtgagtaat 8100 cggttggttg gttgattgat tgattgattg atacattcag cttcctgctg ctagcaatgc 8160 cacgatttag atttaatgat gcttcagtgg aaatcaatca gaaggtattc tgaccttgtg 8220 aacatcagaa ggtatttttt aactcccaag cagtagcagg acgatgatag ggctggaggg 8280 ctatggattc ccagcccatc cctgtgaagg agtaggccac tctttaagtg aaggattgga 8340 tgattgttca taatacataa agttctctgt aattacaact aaattattat gccctcttct 8400 cacagtcaaa aggaactggg tggtttggtt tttgttgctt ttttagattt attgtcccat 8460 gtgggatgag tttttaaatg ccacaagaca taatttaaaa taaataaact ttgggaaaag 8520 gtgtaaaaca gtagccccat cacatttgtg atactgacag gtatcaaccc agaagcccat 8580 gaactgtgtt tccatccttt gcatttctct gcgagtagtt ccacacaggt ttgtaagtaa 8640 gtaagaaaga aggcaaattg attcaaatgt tacaaaaaaa cccttcttgg tggattagac 8700 aggttaaata tataaacaaa caaacaaaaa ttgctcaaaa aagaggagaa aagctcaaga 8760 ggaaaagcta aggactggta ggaaaaagct ttactctttc atgccatttt atttcttttt 8820 gatttttaaa tcattcattc aatagatacc accgtgtgac ctataatttt gcaaatctgt 8880 tacctctgac atcaagtgta attagctttt ggagagtggg ctgacatcaa gtgtaattag 8940 cttttggaga gtgggttttg tccattatta ataattaatt aattaacatc aaacacggct 9000 tctcatgcta tttctacctc actttggttt tggggtgttc ctgataattg tgcacacctg 9060 agttcacagc ttcaccactt gtccattgcg ttattttctt tttcctttat aattctttct 9120 ttttccttca taattttcaa aagaaaaccc aaagctctaa ggtaacaaat taccaaatta 9180 catgaagatt tggtttttgt cttgcatttt tttcctttat gtgacgctgg accttttctt 9240 tacccaagga tttttaaaac tcagatttaa aacaaggggt tactttacat cctactaaga 9300 agtttaagta agtaagtttc attctaaaat cagaggtaaa tagagtgcat aaataatttt 9360 gttttaatct ttttgttttt cttttagaca cattagctct ggagtgagtc tgtcataata 9420 tttgaacaaa aattgagagc tttattgctg cattttaagc ataattaatt tggacattat 9480 ttcgtgttgt gttctttata accaccaagt attaaactgt aaatcataat gtaactgaag 9540 cataaacatc acatggcatg ttttgtcatt gttttcaggt actgagttct tacttgagta 9600 tcataatata ttgtgtttta acaccaacac tgtaacattt acgaattatt tttttaaact 9660 tcagttttac tgcattttca caacatatca gacttcacca aatatatgcc ttactattgt 9720 attatagtac tgctttactg tgtatctcaa taaagcacgc agttatgtta c 9771 <210> 13 <211> 2344 <212> PRT <213> Homo sapiens <400> 13 Met Thr Glu Met Ile Leu Leu Ile Phe Phe Pro Ala Tyr Phe Leu Asn 1 5 10 15 Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser Ile Gln Ser Ala Gln 20 25 30 Glu Thr Glu Lys Ser Leu His Leu Ile Gln Glu Ser Leu Thr Phe Ile 35 40 45 Asp Lys Gln Leu Ala Ala Tyr Ile Ala Asp Lys Val Asp Ala Ala Gln 50 55 60 Met Pro Gln Glu Ala Gln Lys Ile Gln Ser Asp Leu Thr Ser His Glu 65 70 75 80 Ile Ser Leu Glu Glu Met Lys Lys His Asn Gln Gly Lys Glu Ala Ala 85 90 95 Gln Arg Val Leu Ser Gln Ile Asp Val Ala Gln Lys Lys Leu Gln Asp 100 105 110 Val Ser Met Lys Phe Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln 115 120 125 Arg Leu Gln Glu Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu 130 135 140 Pro Ala Leu Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln 145 150 155 160 Leu Asn His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser 165 170 175 Glu Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 180 185 190 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu Lys 195 200 205 Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys Gln Gln 210 215 220 Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys Glu Met Asn 225 230 235 240 Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu Leu Thr Lys Arg 245 250 255 Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp Ser Glu Val Ala Trp 260 265 270 Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys Gln Lys Val His Leu Lys 275 280 285 Ser Ile Thr Glu Val Gly Glu Ala Leu Lys Thr Val Leu Gly Lys Lys 290 295 300 Glu Thr Leu Val Glu Asp Lys Leu Ser Leu Leu Asn Ser Asn Trp Ile 305 310 315 320 Ala Val Thr Ser Arg Ala Glu Glu Trp Leu Asn Leu Leu Leu Glu Tyr 325 330 335 Gln Lys His Met Glu Thr Phe Asp Gln Asn Val Asp His Ile Thr Lys 340 345 350 Trp Ile Ile Gln Ala Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys 355 360 365 Pro Gln Gln Lys Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn 370 375 380 Asp Ile Arg Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu 385 390 395 400 Met Ala Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile 405 410 415 Ser Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 420 425 430 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser Asp 435 440 445 Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln Gly Val 450 455 460 Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu Asp Asn Glu 465 470 475 480 Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn Leu Gln Gln Arg 485 490 495 Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys Ile Lys Gln Gln Leu 500 505 510 Leu Gln Thr Lys His Asn Ala Leu Lys Asp Leu Arg Ser Gln Arg Arg 515 520 525 Lys Lys Ala Leu Glu Ile Ser His Gln Trp Tyr Gln Tyr Lys Arg Gln 530 535 540 Ala Asp Asp Leu Leu Lys Cys Leu Asp Asp Ile Glu Lys Lys Leu Ala 545 550 555 560 Ser Leu Pro Glu Pro Arg Asp Glu Arg Lys Ile Lys Glu Ile Asp Arg 565 570 575 Glu Leu Gln Lys Lys Lys Glu Glu Leu Asn Ala Val Arg Arg Gln Ala 580 585 590 Glu Gly Leu Ser Glu Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln 595 600 605 Ile Gln Leu Ser Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln 610 615 620 Phe Arg Arg Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr 625 630 635 640 Met Met Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro 645 650 655 Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu 660 665 670 Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu 675 680 685 Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu 690 695 700 Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys Thr Ala 705 710 715 720 Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln Glu Ala 725 730 735 Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr Lys 740 745 750 Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg Arg Phe 755 760 765 His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln 770 775 780 Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys Tyr 785 790 795 800 Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr 805 810 815 Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser 820 825 830 Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn 835 840 845 Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg 850 855 860 Leu Glu Glu Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn 865 870 875 880 Glu Phe Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro 885 890 895 Leu Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val 900 905 910 Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys Gln 915 920 925 Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile Ser Pro 930 935 940 Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr Asn Leu Gln 945 950 955 960 Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln Gly Glu Ile Glu 965 970 975 Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys Lys Leu Glu Asp Leu 980 985 990 Glu Glu Gln Leu Asn His Leu Leu Leu Trp Leu Ser Pro Ile Arg Asn 995 1000 1005 Gln Leu Glu Ile Tyr Asn Gln Pro Asn Gln Glu Gly Pro Phe Asp 1010 1015 1020 Val Gln Glu Thr Glu Ile Ala Val Gln Ala Lys Gln Pro Asp Val 1025 1030 1035 Glu Glu Ile Leu Ser Lys Gly Gln His Leu Tyr Lys Glu Lys Pro 1040 1045 1050 Ala Thr Gln Pro Val Lys Arg Lys Leu Glu Asp Leu Ser Ser Glu 1055 1060 1065 Trp Lys Ala Val Asn Arg Leu Leu Gln Glu Leu Arg Ala Lys Gln 1070 1075 1080 Pro Asp Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr 1085 1090 1095 Gln Thr Val Thr Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr 1100 1105 1110 Ala Ile Ser Lys Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val 1115 1120 1125 Pro Ala Leu Ala Asp Phe Asn Arg Ala Trp Thr Glu Leu Thr Asp 1130 1135 1140 Trp Leu Ser Leu Leu Asp Gln Val Ile Lys Ser Gln Arg Val Met 1145 1150 1155 Val Gly Asp Leu Glu Asp Ile Asn Glu Met Ile Ile Lys Gln Lys 1160 1165 1170 Ala Thr Met Gln Asp Leu Glu Gln Arg Arg Pro Gln Leu Glu Glu 1175 1180 1185 Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn Lys Thr Ser Asn Gln 1190 1195 1200 Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg Ile Gln Asn 1205 1210 1215 Gln Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg Gln Gln 1220 1225 1230 Leu Asn Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala Lys 1235 1240 1245 Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu 1250 1255 1260 Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys 1265 1270 1275 Ile Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln 1280 1285 1290 Thr Asn Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg 1295 1300 1305 Asp Tyr Ser Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu 1310 1315 1320 Asn Ile Asn Ala Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu 1325 1330 1335 Arg Glu Ala Ala Leu Glu Glu Thr His Arg Leu Leu Gln Gln Phe 1340 1345 1350 Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp Leu Thr Glu Ala Glu 1355 1360 1365 Thr Thr Ala Asn Val Leu Gln Asp Ala Thr Arg Lys Glu Arg Leu 1370 1375 1380 Leu Glu Asp Ser Lys Gly Val Lys Glu Leu Met Lys Gln Trp Gln 1385 1390 1395 Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr His Asn 1400 1405 1410 Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly Ser 1415 1420 1425 Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn Phe 1430 1435 1440 Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His 1445 1450 1455 Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu 1460 1465 1470 Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser 1475 1480 1485 Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln 1490 1495 1500 Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu 1505 1510 1515 Pro Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr 1520 1525 1530 Glu Gln Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg 1535 1540 1545 Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu 1550 1555 1560 Arg Lys Gln Ala Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn 1565 1570 1575 Leu His Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu 1580 1585 1590 Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys 1595 1600 1605 Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly 1610 1615 1620 Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys 1625 1630 1635 Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His 1640 1645 1650 Val Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu 1655 1660 1665 Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp 1670 1675 1680 Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His 1685 1690 1695 Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser 1700 1705 1710 Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys 1715 1720 1725 Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp 1730 1735 1740 His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn 1745 1750 1755 Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg 1760 1765 1770 Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala 1775 1780 1785 Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro 1790 1795 1800 Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp 1805 1810 1815 Arg Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys 1820 1825 1830 Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly 1835 1840 1845 Arg Thr Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile 1850 1855 1860 Ser Leu Cys Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe 1865 1870 1875 Lys Gln Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu 1880 1885 1890 Gly Leu Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly 1895 1900 1905 Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg 1910 1915 1920 Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala 1925 1930 1935 Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met Val Trp 1940 1945 1950 Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys His 1955 1960 1965 Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 1970 1975 1980 Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser 1985 1990 1995 Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr 2000 2005 2010 Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val 2015 2020 2025 Arg Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg 2030 2035 2040 Tyr Phe Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr 2045 2050 2055 Val Leu Glu Gly Asp Asn Met Glu Thr Pro Val Thr Leu Ile Asn 2060 2065 2070 Phe Trp Pro Val Asp Ser Ala Pro Ala Ser Ser Pro Gln Leu Ser 2075 2080 2085 His Asp Asp Thr His Ser Arg Ile Glu His Tyr Ala Ser Arg Leu 2090 2095 2100 Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile 2105 2110 2115 Ser Pro Asn Glu Ser Ile Asp Asp Glu His Leu Leu Ile Gln His 2120 2125 2130 Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro Arg 2135 2140 2145 Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu Arg Gly 2150 2155 2160 Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn 2165 2170 2175 Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys 2180 2185 2190 Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser 2195 2200 2205 Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu 2210 2215 2220 Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu 2225 2230 2235 Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg 2240 2245 2250 Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr 2255 2260 2265 Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser 2270 2275 2280 Gln Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser 2285 2290 2295 Met Gly Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr 2300 2305 2310 Gly Leu Glu Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser 2315 2320 2325 Ser Arg Gly Arg Asn Thr Pro Gly Lys Pro Met Arg Glu Asp Thr 2330 2335 2340 Met <210> 14 <211> 9914 <212> DNA <213> Homo sapiens <400> 14 taatgagatc aggaggaaca ttcgacctga gaaagacaga ttgcaatgac tgagatgatt 60 ttgctaattt tttttccagc ctatttcctt aatgtacgtg atattgtgat tgattttcat 120 gcagagatcc ctgatcctat agttttgttt gctatttatt tttctccttc acattttttt 180 tctatcaaca gagctgaatg agtgccagga agctgcgaaa tctgtcttac aaaaaggctg 240 taaggaggca aaagttgctt gaacagagca tccagtctgc ccaggagact gaaaaatcct 300 tacacttaat ccaggagtcc ctcacattca ttgacaagca gttggcagct tatattgcag 360 acaaggtgga cgcagctcaa atgcctcagg aagcccagaa aatccaatct gatttgacaa 420 gtcatgagat cagtttagaa gaaatgaaga aacataatca ggggaaggag gctgcccaaa 480 gagtcctgtc tcagattgat gttgcacaga aaaaattaca agatgtctcc atgaagtttc 540 gattattcca gaaaccagcc aattttgagc agcgtctaca agaaagtaag atgattttag 600 atgaagtgaa gatgcacttg cctgcattgg aaacaaagag tgtggaacag gaagtagtac 660 agtcacagct aaatcattgt gtgaacttgt ataaaagtct gagtgaagtg aagtctgaag 720 tggaaatggt gataaagact ggacgtcaga ttgtacagaa aaagcagacg gaaaatccca 780 aagaacttga tgaaagagta acagctttga aattgcatta taatgagctg ggagcaaagg 840 taacagaaag aaagcaacag ttggagaaat gcttgaaatt gtcccgtaag atgcgaaagg 900 aaatgaatgt cttgacagaa tggctggcag ctacagatat ggaattgaca aagagatcag 960 cagttgaagg aatgcctagt aatttggatt ctgaagttgc ctggggaaag gctactcaaa 1020 aagagattga gaaacagaag gtgcacctga agagtatcac agaggtagga gaggccttga 1080 aaacagtttt gggcaagaag gagacgttgg tggaagataa actcagtctt ctgaatagta 1140 actggatagc tgtcacctcc cgagcagaag agtggttaaa tcttttgttg gaataccaga 1200 aacacatgga aacttttgac cagaatgtgg accacatcac aaagtggatc attcaggctg 1260 acacactttt ggatgaatca gagaaaaaga aaccccagca aaaagaagac gtgcttaagc 1320 gtttaaaggc agaactgaat gacatacgcc caaaggtgga ctctacacgt gaccaagcag 1380 caaacttgat ggcaaaccgc ggtgaccact gcaggaaatt agtagagccc caaatctcag 1440 agctcaacca tcgatttgca gccatttcac acagaattaa gactggaaag gcctccattc 1500 ctttgaagga attggagcag tttaactcag atatacaaaa attgcttgaa ccactggagg 1560 ctgaaattca gcagggggtg aatctgaaag aggaagactt caataaagat atgaatgaag 1620 acaatgaggg tactgtaaaa gaattgttgc aaagaggaga caacttacaa caaagaatca 1680 cagatgagag aaagcgagag gaaataaaga taaaacagca gctgttacag acaaaacata 1740 atgctctcaa ggatttgagg tctcaaagaa gaaaaaaggc tctagaaatt tctcatcagt 1800 ggtatcagta caagaggcag gctgatgatc tcctgaaatg cttggatgac attgaaaaaa 1860 aattagccag cctacctgag cccagagatg aaaggaaaat aaaggaaatt gatcgggaat 1920 tgcagaagaa gaaagaggag ctgaatgcag tgcgtaggca agctgagggc ttgtctgagg 1980 atggggccgc aatggcagtg gagccaactc agatccagct cagcaagcgc tggcgggaaa 2040 ttgagagcaa atttgctcag tttcgaagac tcaactttgc acaaattcac actgtccgtg 2100 aagaaacgat gatggtgatg actgaagaca tgcctttgga aatttcttat gtgccttcta 2160 cttatttgac tgaaatcact catgtctcac aagccctatt agaagtggaa caacttctca 2220 atgctcctga cctctgtgct aaggactttg aagatctctt taagcaagag gagtctctga 2280 agaatataaa agatagtcta caacaaagct caggtcggat tgacattatt catagcaaga 2340 agacagcagc attgcaaagt gcaacgcctg tggaaagggt gaagctacag gaagctctct 2400 cccagcttga tttccaatgg gaaaaagtta acaaaatgta caaggaccga caagggcgat 2460 ttgacagatc tgttgagaaa tggcggcgtt ttcattatga tataaagata tttaatcagt 2520 ggctaacaga agctgaacag tttctcagaa agacacaaat tcctgagaat tgggaacatg 2580 ctaaatacaa atggtatctt aaggaactcc aggatggcat tgggcagcgg caaactgttg 2640 tcagaacatt gaatgcaact ggggaagaaa taattcagca atcctcaaaa acagatgcca 2700 gtattctaca ggaaaaattg ggaagcctga atctgcggtg gcaggaggtc tgcaaacagc 2760 tgtcagacag aaaaaagagg ctagaagaac aaaagaatat cttgtcagaa tttcaaagag 2820 atttaaatga atttgtttta tggttggagg aagcagataa cattgctagt atcccacttg 2880 aacctggaaa agagcagcaa ctaaaagaaa agcttgagca agtcaagtta ctggtggaag 2940 agttgcccct gcgccaggga attctcaaac aattaaatga aactggagga cccgtgcttg 3000 taagtgctcc cataagccca gaagagcaag ataaacttga aaataagctc aagcagacaa 3060 atctccagtg gataaaggtt tccagagctt tacctgagaa acaaggagaa attgaagctc 3120 aaataaaaga ccttgggcag cttgaaaaaa agcttgaaga ccttgaagag cagttaaatc 3180 atctgctgct gtggttatct cctattagga atcagttgga aatttataac caaccaaacc 3240 aagaaggacc atttgacgtt caggaaactg aaatagcagt tcaagctaaa caaccggatg 3300 tggaagagat tttgtctaaa gggcagcatt tgtacaagga aaaaccagcc actcagccag 3360 tgaagaggaa gttagaagat ctgagctctg agtggaaggc ggtaaaccgt ttacttcaag 3420 agctgagggc aaagcagcct gacctagctc ctggactgac cactattgga gcctctccta 3480 ctcagactgt tactctggtg acacaacctg tggttactaa ggaaactgcc atctccaaac 3540 tagaaatgcc atcttccttg atgttggagg tacctgctct ggcagatttc aaccgggctt 3600 ggacagaact taccgactgg ctttctctgc ttgatcaagt tataaaatca cagagggtga 3660 tggtgggtga ccttgaggat atcaacgaga tgatcatcaa gcagaaggca acaatgcagg 3720 atttggaaca gaggcgtccc cagttggaag aactcattac cgctgcccaa aatttgaaaa 3780 acaagaccag caatcaagag gctagaacaa tcattacgga tcgaattgaa agaattcaga 3840 atcagtggga tgaagtacaa gaacaccttc agaaccggag gcaacagttg aatgaaatgt 3900 taaaggattc aacacaatgg ctggaagcta aggaagaagc tgagcaggtc ttaggacagg 3960 ccagagccaa gcttgagtca tggaaggagg gtccctatac agtagatgca atccaaaaga 4020 aaatcacaga aaccaagcag ttggccaaag acctccgcca gtggcagaca aatgtagatg 4080 tggcaaatga cttggccctg aaacttctcc gggattattc tgcagatgat accagaaaag 4140 tccacatgat aacagagaat atcaatgcct cttggagaag cattcataaa agggtgagtg 4200 agcgagaggc tgctttggaa gaaactcata gattactgca acagttcccc ctggacctgg 4260 aaaagtttct tgcctggctt acagaagctg aaacaactgc caatgtccta caggatgcta 4320 cccgtaagga aaggctccta gaagactcca agggagtaaa agagctgatg aaacaatggc 4380 aagacctcca aggtgaaatt gaagctcaca cagatgttta tcacaacctg gatgaaaaca 4440 gccaaaaaat cctgagatcc ctggaaggtt ccgatgatgc agtcctgtta caaagacgtt 4500 tggataacat gaacttcaag tggagtgaac ttcggaaaaa gtctctcaac attaggtccc 4560 atttggaagc cagttctgac cagtggaagc gtctgcacct ttctctgcag gaacttctgg 4620 tgtggctaca gctgaaagat gatgaattaa gccggcaggc acctattgga ggcgactttc 4680 cagcagttca gaagcagaac gatgtacata gggccttcaa gagggaattg aaaactaaag 4740 aacctgtaat catgagtact cttgagactg tacgaatatt tctgacagag cagcctttgg 4800 aaggactaga gaaactctac caggagccca gagagctgcc tcctgaggag agagcccaga 4860 atgtcactcg gcttctacga aagcaggctg aggaggtcaa tactgagtgg gaaaaattga 4920 acctgcactc cgctgactgg cagagaaaaa tagatgagac ccttgaaaga ctccaggaac 4980 ttcaagaggc cacggatgag ctggacctca agctgcgcca agctgaggtg atcaagggat 5040 cctggcagcc cgtgggcgat ctcctcattg actctctcca agatcacctc gagaaagtca 5100 aggcacttcg aggagaaatt gcgcctctga aagagaacgt gagccacgtc aatgaccttg 5160 ctcgccagct taccactttg ggcattcagc tctcaccgta taacctcagc actctggaag 5220 acctgaacac cagatggaag cttctgcagg tggccgtcga ggaccgagtc aggcagctgc 5280 atgaagccca cagggacttt ggtccagcat ctcagcactt tctttccacg tctgtccagg 5340 gtccctggga gagagccatc tcgccaaaca aagtgcccta ctatatcaac cacgagactc 5400 aaacaacttg ctgggaccat cccaaaatga cagagctcta ccagtcttta gctgacctga 5460 ataatgtcag attctcagct tataggactg ccatgaaact ccgaagactg cagaaggccc 5520 tttgcttgga tctcttgagc ctgtcagctg catgtgatgc cttggaccag cacaacctca 5580 agcaaaatga ccagcccatg gatatcctgc agattattaa ttgtttgacc actatttatg 5640 accgcctgga gcaagagcac aacaatttgg tcaacgtccc tctctgcgtg gatatgtgtc 5700 tgaactggct gctgaatgtt tatgatacgg gacgaacagg gaggatccgt gtcctgtctt 5760 ttaaaactgg catcatttcc ctgtgtaaag cacatttgga agacaagtac agataccttt 5820 tcaagcaagt ggcaagttca acaggatttt gtgaccagcg caggctgggc ctccttctgc 5880 atgattctat ccaaattcca agacagttgg gtgaagttgc atcctttggg ggcagtaaca 5940 ttgagccaag tgtccggagc tgcttccaat ttgctaataa taagccagag atcgaagcgg 6000 ccctcttcct agactggatg agactggaac cccagtccat ggtgtggctg cccgtcctgc 6060 acagagtggc tgctgcagaa actgccaagc atcaggccaa atgtaacatc tgcaaagagt 6120 gtccaatcat tggattcagg tacaggagtc taaagcactt taattatgac atctgccaaa 6180 gctgcttttt ttctggtcga gttgcaaaag gccataaaat gcactatccc atggtggaat 6240 attgcactcc gactacatca ggagaagatg ttcgagactt tgccaaggta ctaaaaaaca 6300 aatttcgaac caaaaggtat tttgcgaagc atccccgaat gggctacctg ccagtgcaga 6360 ctgtcttaga gggggacaac atggaaactc ccgttactct gatcaacttc tggccagtag 6420 attctgcgcc tgcctcgtcc cctcagcttt cacacgatga tactcattca cgcattgaac 6480 attatgctag caggctagca gaaatggaaa acagcaatgg atcttatcta aatgatagca 6540 tctctcctaa tgagagcata gatgatgaac atttgttaat ccagcattac tgccaaagtt 6600 tgaaccagga ctcccccctg agccagcctc gtagtcctgc ccagatcttg atttccttag 6660 agagtgagga aagaggggag ctagagagaa tcctagcaga tcttgaggaa gaaaacagga 6720 atctgcaagc agaatatgac cgtctaaagc agcagcacga acataaaggc ctgtccccac 6780 tgccgtcccc tcctgaaatg atgcccacct ctccccagag tccccgggat gctgagctca 6840 ttgctgaggc caagctactg cgtcaacaca aaggccgcct ggaagccagg atgcaaatcc 6900 tggaagacca caataaacag ctggagtcac agttacacag gctaaggcag ctgctggagc 6960 aaccccaggc agaggccaaa gtgaatggca caacggtgtc ctctccttct acctctctac 7020 agaggtccga cagcagtcag cctatgctgc tccgagtggt tggcagtcaa acttcggact 7080 ccatgggtga ggaagatctt ctcagtcctc cccaggacac aagcacaggg ttagaggagg 7140 tgatggagca actcaacaac tccttcccta gttcaagagg aagaaatacc cctggaaagc 7200 caatgagaga ggacacaatg taggaagtct tttccacatg gcagatgatt tgggcagagc 7260 gatggagtcc ttagtatcag tcatgacaga tgaagaagga gcagaataaa tgttttacaa 7320 ctcctgattc ccgcatggtt tttataatat tcatacaaca aagaggatta gacagtaaga 7380 gtttacaaga aataaatcta tatttttgtg aagggtagtg gtattatact gtagatttca 7440 gtagtttcta agtctgttat tgttttgtta acaatggcag gttttacacg tctatgcaat 7500 tgtacaaaaa agttataaga aaactacatg taaaatcttg atagctaaat aacttgccat 7560 ttctttatat ggaacgcatt ttgggttgtt taaaaattta taacagttat aaagaaagat 7620 tgtaaactaa agtgtgcttt ataaaaaaaa gttgtttata aaaaccccta aaaacaaaac 7680 aaacacacac acacacacat acacacacac acacaaaact ttgaggcagc gcattgtttt 7740 gcatcctttt ggcgtgatat ccatatgaaa ttcatggctt tttctttttt tgcatattaa 7800 agataagact tcctctacca ccacaccaaa tgactactac acactgctca tttgagaact 7860 gtcagctgag tggggcaggc ttgagttttc atttcatata tctatatgtc tataagtata 7920 taaatactat agttatatag ataaagagat acgaatttct atagactgac tttttccatt 7980 ttttaaatgt tcatgtcaca tcctaataga aagaaattac ttctagtcag tcatccaggc 8040 ttacctgctt ggtctagaat ggatttttcc cggagccgga agccaggagg aaactacacc 8100 acactaaaac attgtctaca gctccagatg tttctcattt taaacaactt tccactgaca 8160 acgaaagtaa agtaaagtat tggatttttt taaagggaac atgtgaatga atacacagga 8220 cttattatat cagagtgagt aatcggttgg ttggttgatt gattgattga ttgatacatt 8280 cagcttcctg ctgctagcaa tgccacgatt tagatttaat gatgcttcag tggaaatcaa 8340 tcagaaggta ttctgacctt gtgaacatca gaaggtattt tttaactccc aagcagtagc 8400 aggacgatga tagggctgga gggctatgga ttcccagccc atccctgtga aggagtaggc 8460 cactctttaa gtgaaggatt ggatgattgt tcataataca taaagttctc tgtaattaca 8520 actaaattat tatgccctct tctcacagtc aaaaggaact gggtggtttg gtttttgttg 8580 cttttttaga tttattgtcc catgtgggat gagtttttaa atgccacaag acataattta 8640 aaataaataa actttgggaa aaggtgtaaa acagtagccc catcacattt gtgatactga 8700 caggtatcaa cccagaagcc catgaactgt gtttccatcc tttgcatttc tctgcgagta 8760 gttccacaca ggtttgtaag taagtaagaa agaaggcaaa ttgattcaaa tgttacaaaa 8820 aaacccttct tggtggatta gacaggttaa atatataaac aaacaaacaa aaattgctca 8880 aaaaagagga gaaaagctca agaggaaaag ctaaggactg gtaggaaaaa gctttactct 8940 ttcatgccat tttatttctt tttgattttt aaatcattca ttcaatagat accaccgtgt 9000 gacctataat tttgcaaatc tgttacctct gacatcaagt gtaattagct tttggagagt 9060 gggctgacat caagtgtaat tagcttttgg agagtgggtt ttgtccatta ttaataatta 9120 attaattaac atcaaacacg gcttctcatg ctatttctac ctcactttgg ttttggggtg 9180 ttcctgataa ttgtgcacac ctgagttcac agcttcacca cttgtccatt gcgttatttt 9240 ctttttcctt tataattctt tctttttcct tcataatttt caaaagaaaa cccaaagctc 9300 taaggtaaca aattaccaaa ttacatgaag atttggtttt tgtcttgcat ttttttcctt 9360 tatgtgacgc tggacctttt ctttacccaa ggatttttaa aactcagatt taaaacaagg 9420 ggttacttta catcctacta agaagtttaa gtaagtaagt ttcattctaa aatcagaggt 9480 aaatagagtg cataaataat tttgttttaa tctttttgtt tttcttttag acacattagc 9540 tctggagtga gtctgtcata atatttgaac aaaaattgag agctttattg ctgcatttta 9600 agcataatta atttggacat tatttcgtgt tgtgttcttt ataaccacca agtattaaac 9660 tgtaaatcat aatgtaactg aagcataaac atcacatggc atgttttgtc attgttttca 9720 ggtactgagt tcttacttga gtatcataat atattgtgtt ttaacaccaa cactgtaaca 9780 tttacgaatt atttttttaa acttcagttt tactgcattt tcacaacata tcagacttca 9840 ccaaatatat gccttactat tgtattatag tactgcttta ctgtgtatct caataaagca 9900 cgcagttatg ttac 9914 <210> 15 <211> 2341 <212> PRT <213> Homo sapiens <400> 15 Met Ser Ala Arg Lys Leu Arg Asn Leu Ser Tyr Lys Lys Ala Val Arg 1 5 10 15 Arg Gln Lys Leu Leu Glu Gln Ser Ile Gln Ser Ala Gln Glu Thr Glu 20 25 30 Lys Ser Leu His Leu Ile Gln Glu Ser Leu Thr Phe Ile Asp Lys Gln 35 40 45 Leu Ala Ala Tyr Ile Ala Asp Lys Val Asp Ala Ala Gln Met Pro Gln 50 55 60 Glu Ala Gln Lys Ile Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu 65 70 75 80 Glu Glu Met Lys Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val 85 90 95 Leu Ser Gln Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met 100 105 110 Lys Phe Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln 115 120 125 Glu Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 130 135 140 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn His 145 150 155 160 Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu Val Glu 165 170 175 Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys Gln Thr Glu 180 185 190 Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu Lys Leu His Tyr 195 200 205 Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys Gln Gln Leu Glu Lys 210 215 220 Cys Leu Lys Leu Ser Arg Lys Met Arg Lys Glu Met Asn Val Leu Thr 225 230 235 240 Glu Trp Leu Ala Ala Thr Asp Met Glu Leu Thr Lys Arg Ser Ala Val 245 250 255 Glu Gly Met Pro Ser Asn Leu Asp Ser Glu Val Ala Trp Gly Lys Ala 260 265 270 Thr Gln Lys Glu Ile Glu Lys Gln Lys Val His Leu Lys Ser Ile Thr 275 280 285 Glu Val Gly Glu Ala Leu Lys Thr Val Leu Gly Lys Lys Glu Thr Leu 290 295 300 Val Glu Asp Lys Leu Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr 305 310 315 320 Ser Arg Ala Glu Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His 325 330 335 Met Glu Thr Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile 340 345 350 Gln Ala Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln 355 360 365 Lys Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 370 375 380 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala Asn 385 390 395 400 Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser Glu Leu 405 410 415 Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr Gly Lys Ala 420 425 430 Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser Asp Ile Gln Lys 435 440 445 Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln Gly Val Asn Leu Lys 450 455 460 Glu Glu Asp Phe Asn Lys Asp Met Asn Glu Asp Asn Glu Gly Thr Val 465 470 475 480 Lys Glu Leu Leu Gln Arg Gly Asp Asn Leu Gln Gln Arg Ile Thr Asp 485 490 495 Glu Arg Lys Arg Glu Glu Ile Lys Ile Lys Gln Gln Leu Leu Gln Thr 500 505 510 Lys His Asn Ala Leu Lys Asp Leu Arg Ser Gln Arg Arg Lys Lys Ala 515 520 525 Leu Glu Ile Ser His Gln Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp 530 535 540 Leu Leu Lys Cys Leu Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro 545 550 555 560 Glu Pro Arg Asp Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln 565 570 575 Lys Lys Lys Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu 580 585 590 Ser Glu Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu 595 600 605 Ser Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg 610 615 620 Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val 625 630 635 640 Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr 645 650 655 Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln 660 665 670 Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe 675 680 685 Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser 690 695 700 Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln 705 710 715 720 Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln 725 730 735 Leu Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln 740 745 750 Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp 755 760 765 Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg 770 775 780 Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr 785 790 795 800 Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg 805 810 815 Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr 820 825 830 Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp 835 840 845 Gln Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu 850 855 860 Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe Val 865 870 875 880 Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu Glu Pro 885 890 895 Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val Lys Leu Leu 900 905 910 Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys Gln Leu Asn Glu 915 920 925 Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile Ser Pro Glu Glu Gln 930 935 940 Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr Asn Leu Gln Trp Ile Lys 945 950 955 960 Val Ser Arg Ala Leu Pro Glu Lys Gln Gly Glu Ile Glu Ala Gln Ile 965 970 975 Lys Asp Leu Gly Gln Leu Glu Lys Lys Leu Glu Asp Leu Glu Glu Gln 980 985 990 Leu Asn His Leu Leu Leu Trp Leu Ser Pro Ile Arg Asn Gln Leu Glu 995 1000 1005 Ile Tyr Asn Gln Pro Asn Gln Glu Gly Pro Phe Asp Val Gln Glu 1010 1015 1020 Thr Glu Ile Ala Val Gln Ala Lys Gln Pro Asp Val Glu Glu Ile 1025 1030 1035 Leu Ser Lys Gly Gln His Leu Tyr Lys Glu Lys Pro Ala Thr Gln 1040 1045 1050 Pro Val Lys Arg Lys Leu Glu Asp Leu Ser Ser Glu Trp Lys Ala 1055 1060 1065 Val Asn Arg Leu Leu Gln Glu Leu Arg Ala Lys Gln Pro Asp Leu 1070 1075 1080 Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val 1085 1090 1095 Thr Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser 1100 1105 1110 Lys Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu 1115 1120 1125 Ala Asp Phe Asn Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser 1130 1135 1140 Leu Leu Asp Gln Val Ile Lys Ser Gln Arg Val Met Val Gly Asp 1145 1150 1155 Leu Glu Asp Ile Asn Glu Met Ile Ile Lys Gln Lys Ala Thr Met 1160 1165 1170 Gln Asp Leu Glu Gln Arg Arg Pro Gln Leu Glu Glu Leu Ile Thr 1175 1180 1185 Ala Ala Gln Asn Leu Lys Asn Lys Thr Ser Asn Gln Glu Ala Arg 1190 1195 1200 Thr Ile Ile Thr Asp Arg Ile Glu Arg Ile Gln Asn Gln Trp Asp 1205 1210 1215 Glu Val Gln Glu His Leu Gln Asn Arg Arg Gln Gln Leu Asn Glu 1220 1225 1230 Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala Lys Glu Glu Ala 1235 1240 1245 Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu Ser Trp Lys 1250 1255 1260 Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile Thr Glu 1265 1270 1275 Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn Val 1280 1285 1290 Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr Ser 1295 1300 1305 Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile Asn 1310 1315 1320 Ala Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu Ala 1325 1330 1335 Ala Leu Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu Asp 1340 1345 1350 Leu Glu Lys Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala 1355 1360 1365 Asn Val Leu Gln Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu Asp 1370 1375 1380 Ser Lys Gly Val Lys Glu Leu Met Lys Gln Trp Gln Asp Leu Gln 1385 1390 1395 Gly Glu Ile Glu Ala His Thr Asp Val Tyr His Asn Leu Asp Glu 1400 1405 1410 Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp Ala 1415 1420 1425 Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn Phe Lys Trp Ser 1430 1435 1440 Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His Leu Glu Ala 1445 1450 1455 Ser Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu Leu 1460 1465 1470 Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala 1475 1480 1485 Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val 1490 1495 1500 His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile 1505 1510 1515 Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln Pro 1520 1525 1530 Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro 1535 1540 1545 Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln 1550 1555 1560 Ala Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser 1565 1570 1575 Ala Asp Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln 1580 1585 1590 Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln 1595 1600 1605 Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu 1610 1615 1620 Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg 1625 1630 1635 Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp 1640 1645 1650 Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr 1655 1660 1665 Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu 1670 1675 1680 Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His 1685 1690 1695 Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val 1700 1705 1710 Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr 1715 1720 1725 Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys 1730 1735 1740 Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg 1745 1750 1755 Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln Lys 1760 1765 1770 Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 1775 1780 1785 Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile 1790 1795 1800 Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu 1805 1810 1815 Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met 1820 1825 1830 Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly 1835 1840 1845 Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys 1850 1855 1860 Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val 1865 1870 1875 Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu 1880 1885 1890 Leu His Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala 1895 1900 1905 Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe 1910 1915 1920 Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu 1925 1930 1935 Asp Trp Met Arg Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val 1940 1945 1950 Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala Lys 1955 1960 1965 Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe Arg Tyr Arg 1970 1975 1980 Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys Phe Phe 1985 1990 1995 Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met Val 2000 2005 2010 Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 2015 2020 2025 Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala 2030 2035 2040 Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu 2045 2050 2055 Gly Asp Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro 2060 2065 2070 Val Asp Ser Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp 2075 2080 2085 Thr His Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met 2090 2095 2100 Glu Asn Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn 2105 2110 2115 Glu Ser Ile Asp Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln 2120 2125 2130 Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala 2135 2140 2145 Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu Arg Gly Glu Leu Glu 2150 2155 2160 Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn Leu Gln Ala 2165 2170 2175 Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys Gly Leu Ser 2180 2185 2190 Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro Gln Ser 2195 2200 2205 Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln 2210 2215 2220 His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu Asp His 2225 2230 2235 Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu Leu 2240 2245 2250 Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser 2255 2260 2265 Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met 2270 2275 2280 Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu 2285 2290 2295 Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu 2300 2305 2310 Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly 2315 2320 2325 Arg Asn Thr Pro Gly Lys Pro Met Arg Glu Asp Thr Met 2330 2335 2340 <210> 16 <211> 7410 <212> DNA <213> Homo sapiens <400> 16 acactagcaa tggcaaagct ttgtgcggag gcattgctgg ctgctctgaa ctaaaagcat 60 ccgtggggac cgaaagaggt ttttgcacac cttattaagg aactccagga tggcattggg 120 cagcggcaaa ctgttgtcag aacattgaat gcaactgggg aagaaataat tcagcaatcc 180 tcaaaaacag atgccagtat tctacaggaa aaattgggaa gcctgaatct gcggtggcag 240 gaggtctgca aacagctgtc agacagaaaa aagaggctag aagaacaaaa gaatatcttg 300 tcagaatttc aaagagattt aaatgaattt gttttatggt tggaggaagc agataacatt 360 gctagtatcc cacttgaacc tggaaaagag cagcaactaa aagaaaagct tgagcaagtc 420 aagttactgg tggaagagtt gcccctgcgc cagggaattc tcaaacaatt aaatgaaact 480 ggaggacccg tgcttgtaag tgctcccata agcccagaag agcaagataa acttgaaaat 540 aagctcaagc agacaaatct ccagtggata aaggtttcca gagctttacc tgagaaacaa 600 ggagaaattg aagctcaaat aaaagacctt gggcagcttg aaaaaaagct tgaagacctt 660 gaagagcagt taaatcatct gctgctgtgg ttatctccta ttaggaatca gttggaaatt 720 tataaccaac caaaccaaga aggaccattt gacgttcagg aaactgaaat agcagttcaa 780 gctaaacaac cggatgtgga agagattttg tctaaagggc agcatttgta caaggaaaaa 840 ccagccactc agccagtgaa gaggaagtta gaagatctga gctctgagtg gaaggcggta 900 aaccgtttac ttcaagagct gagggcaaag cagcctgacc tagctcctgg actgaccact 960 attggagcct ctcctactca gactgttact ctggtgacac aacctgtggt tactaaggaa 1020 actgccatct ccaaactaga aatgccatct tccttgatgt tggaggtacc tgctctggca 1080 gatttcaacc gggcttggac agaacttacc gactggcttt ctctgcttga tcaagttata 1140 aaatcacaga gggtgatggt gggtgacctt gaggatatca acgagatgat catcaagcag 1200 aaggcaacaa tgcaggattt ggaacagagg cgtccccagt tggaagaact cattaccgct 1260 gcccaaaatt tgaaaaacaa gaccagcaat caagaggcta gaacaatcat tacggatcga 1320 attgaaagaa ttcagaatca gtgggatgaa gtacaagaac accttcagaa ccggaggcaa 1380 cagttgaatg aaatgttaaa ggattcaaca caatggctgg aagctaagga agaagctgag 1440 caggtcttag gacaggccag agccaagctt gagtcatgga aggagggtcc ctatacagta 1500 gatgcaatcc aaaagaaaat cacagaaacc aagcagttgg ccaaagacct ccgccagtgg 1560 cagacaaatg tagatgtggc aaatgacttg gccctgaaac ttctccggga ttattctgca 1620 gatgatacca gaaaagtcca catgataaca gagaatatca atgcctcttg gagaagcatt 1680 cataaaaggg tgagtgagcg agaggctgct ttggaagaaa ctcatagatt actgcaacag 1740 ttccccctgg acctggaaaa gtttcttgcc tggcttacag aagctgaaac aactgccaat 1800 gtcctacagg atgctacccg taaggaaagg ctcctagaag actccaaggg agtaaaagag 1860 ctgatgaaac aatggcaaga cctccaaggt gaaattgaag ctcacacaga tgtttatcac 1920 aacctggatg aaaacagcca aaaaatcctg agatccctgg aaggttccga tgatgcagtc 1980 ctgttacaaa gacgtttgga taacatgaac ttcaagtgga gtgaacttcg gaaaaagtct 2040 ctcaacatta ggtcccattt ggaagccagt tctgaccagt ggaagcgtct gcacctttct 2100 ctgcaggaac ttctggtgtg gctacagctg aaagatgatg aattaagccg gcaggcacct 2160 attggaggcg actttccagc agttcagaag cagaacgatg tacatagggc cttcaagagg 2220 gaattgaaaa ctaaagaacc tgtaatcatg agtactcttg agactgtacg aatatttctg 2280 acagagcagc ctttggaagg actagagaaa ctctaccagg agcccagaga gctgcctcct 2340 gaggagagag cccagaatgt cactcggctt ctacgaaagc aggctgagga ggtcaatact 2400 gagtgggaaa aattgaacct gcactccgct gactggcaga gaaaaataga tgagaccctt 2460 gaaagactcc aggaacttca agaggccacg gatgagctgg acctcaagct gcgccaagct 2520 gaggtgatca agggatcctg gcagcccgtg ggcgatctcc tcattgactc tctccaagat 2580 cacctcgaga aagtcaaggc acttcgagga gaaattgcgc ctctgaaaga gaacgtgagc 2640 cacgtcaatg accttgctcg ccagcttacc actttgggca ttcagctctc accgtataac 2700 ctcagcactc tggaagacct gaacaccaga tggaagcttc tgcaggtggc cgtcgaggac 2760 cgagtcaggc agctgcatga agcccacagg gactttggtc cagcatctca gcactttctt 2820 tccacgtctg tccagggtcc ctgggagaga gccatctcgc caaacaaagt gccctactat 2880 atcaaccacg agactcaaac aacttgctgg gaccatccca aaatgacaga gctctaccag 2940 tctttagctg acctgaataa tgtcagattc tcagcttata ggactgccat gaaactccga 3000 agactgcaga aggccctttg cttggatctc ttgagcctgt cagctgcatg tgatgccttg 3060 gaccagcaca acctcaagca aaatgaccag cccatggata tcctgcagat tattaattgt 3120 ttgaccacta tttatgaccg cctggagcaa gagcacaaca atttggtcaa cgtccctctc 3180 tgcgtggata tgtgtctgaa ctggctgctg aatgtttatg atacgggacg aacagggagg 3240 atccgtgtcc tgtcttttaa aactggcatc atttccctgt gtaaagcaca tttggaagac 3300 aagtacagat accttttcaa gcaagtggca agttcaacag gattttgtga ccagcgcagg 3360 ctgggcctcc ttctgcatga ttctatccaa attccaagac agttgggtga agttgcatcc 3420 tttgggggca gtaacattga gccaagtgtc cggagctgct tccaatttgc taataataag 3480 ccagagatcg aagcggccct cttcctagac tggatgagac tggaacccca gtccatggtg 3540 tggctgcccg tcctgcacag agtggctgct gcagaaactg ccaagcatca ggccaaatgt 3600 aacatctgca aagagtgtcc aatcattgga ttcaggtaca ggagtctaaa gcactttaat 3660 tatgacatct gccaaagctg ctttttttct ggtcgagttg caaaaggcca taaaatgcac 3720 tatcccatgg tggaatattg cactccgact acatcaggag aagatgttcg agactttgcc 3780 aaggtactaa aaaacaaatt tcgaaccaaa aggtattttg cgaagcatcc ccgaatgggc 3840 tacctgccag tgcagactgt cttagagggg gacaacatgg aaactcccgt tactctgatc 3900 aacttctggc cagtagattc tgcgcctgcc tcgtcccctc agctttcaca cgatgatact 3960 cattcacgca ttgaacatta tgctagcagg ctagcagaaa tggaaaacag caatggatct 4020 tatctaaatg atagcatctc tcctaatgag agcatagatg atgaacattt gttaatccag 4080 cattactgcc aaagtttgaa ccaggactcc cccctgagcc agcctcgtag tcctgcccag 4140 atcttgattt ccttagagag tgaggaaaga ggggagctag agagaatcct agcagatctt 4200 gaggaagaaa acaggaatct gcaagcagaa tatgaccgtc taaagcagca gcacgaacat 4260 aaaggcctgt ccccactgcc gtcccctcct gaaatgatgc ccacctctcc ccagagtccc 4320 cgggatgctg agctcattgc tgaggccaag ctactgcgtc aacacaaagg ccgcctggaa 4380 gccaggatgc aaatcctgga agaccacaat aaacagctgg agtcacagtt acacaggcta 4440 aggcagctgc tggagcaacc ccaggcagag gccaaagtga atggcacaac ggtgtcctct 4500 ccttctacct ctctacagag gtccgacagc agtcagccta tgctgctccg agtggttggc 4560 agtcaaactt cggactccat gggtgaggaa gatcttctca gtcctcccca ggacacaagc 4620 acagggttag aggaggtgat ggagcaactc aacaactcct tccctagttc aagaggaaga 4680 aatacccctg gaaagccaat gagagaggac acaatgtagg aagtcttttc cacatggcag 4740 atgatttggg cagagcgatg gagtccttag tatcagtcat gacagatgaa gaaggagcag 4800 aataaatgtt ttacaactcc tgattcccgc atggttttta taatattcat acaacaaaga 4860 ggattagaca gtaagagttt acaagaaata aatctatatt tttgtgaagg gtagtggtat 4920 tatactgtag atttcagtag tttctaagtc tgttattgtt ttgttaacaa tggcaggttt 4980 tacacgtcta tgcaattgta caaaaaagtt ataagaaaac tacatgtaaa atcttgatag 5040 ctaaataact tgccatttct ttatatggaa cgcattttgg gttgtttaaa aatttataac 5100 agttataaag aaagattgta aactaaagtg tgctttataa aaaaaagttg tttataaaaa 5160 cccctaaaaa caaaacaaac acacacacac acacatacac acacacacac aaaactttga 5220 ggcagcgcat tgttttgcat ccttttggcg tgatatccat atgaaattca tggctttttc 5280 tttttttgca tattaaagat aagacttcct ctaccaccac accaaatgac tactacacac 5340 tgctcatttg agaactgtca gctgagtggg gcaggcttga gttttcattt catatatcta 5400 tatgtctata agtatataaa tactatagtt atatagataa agagatacga atttctatag 5460 actgactttt tccatttttt aaatgttcat gtcacatcct aatagaaaga aattacttct 5520 agtcagtcat ccaggcttac ctgcttggtc tagaatggat ttttcccgga gccggaagcc 5580 aggaggaaac tacaccacac taaaacattg tctacagctc cagatgtttc tcattttaaa 5640 caactttcca ctgacaacga aagtaaagta aagtattgga tttttttaaa gggaacatgt 5700 gaatgaatac acaggactta ttatatcaga gtgagtaatc ggttggttgg ttgattgatt 5760 gattgattga tacattcagc ttcctgctgc tagcaatgcc acgatttaga tttaatgatg 5820 cttcagtgga aatcaatcag aaggtattct gaccttgtga acatcagaag gtatttttta 5880 actcccaagc agtagcagga cgatgatagg gctggagggc tatggattcc cagcccatcc 5940 ctgtgaagga gtaggccact ctttaagtga aggattggat gattgttcat aatacataaa 6000 gttctctgta attacaacta aattattatg ccctcttctc acagtcaaaa ggaactgggt 6060 ggtttggttt ttgttgcttt tttagattta ttgtcccatg tgggatgagt ttttaaatgc 6120 cacaagacat aatttaaaat aaataaactt tgggaaaagg tgtaaaacag tagccccatc 6180 acatttgtga tactgacagg tatcaaccca gaagcccatg aactgtgttt ccatcctttg 6240 catttctctg cgagtagttc cacacaggtt tgtaagtaag taagaaagaa ggcaaattga 6300 ttcaaatgtt acaaaaaaac ccttcttggt ggattagaca ggttaaatat ataaacaaac 6360 aaacaaaaat tgctcaaaaa agaggagaaa agctcaagag gaaaagctaa ggactggtag 6420 gaaaaagctt tactctttca tgccatttta tttctttttg atttttaaat cattcattca 6480 atagatacca ccgtgtgacc tataattttg caaatctgtt acctctgaca tcaagtgtaa 6540 ttagcttttg gagagtgggc tgacatcaag tgtaattagc ttttggagag tgggttttgt 6600 ccattattaa taattaatta attaacatca aacacggctt ctcatgctat ttctacctca 6660 ctttggtttt ggggtgttcc tgataattgt gcacacctga gttcacagct tcaccacttg 6720 tccattgcgt tattttcttt ttcctttata attctttctt tttccttcat aattttcaaa 6780 agaaaaccca aagctctaag gtaacaaatt accaaattac atgaagattt ggtttttgtc 6840 ttgcattttt ttcctttatg tgacgctgga ccttttcttt acccaaggat ttttaaaact 6900 cagatttaaa acaaggggtt actttacatc ctactaagaa gtttaagtaa gtaagtttca 6960 ttctaaaatc agaggtaaat agagtgcata aataattttg ttttaatctt tttgtttttc 7020 ttttagacac attagctctg gagtgagtct gtcataatat ttgaacaaaa attgagagct 7080 ttattgctgc attttaagca taattaattt ggacattatt tcgtgttgtg ttctttataa 7140 ccaccaagta ttaaactgta aatcataatg taactgaagc ataaacatca catggcatgt 7200 tttgtcattg ttttcaggta ctgagttctt acttgagtat cataatatat tgtgttttaa 7260 caccaacact gtaacattta cgaattattt ttttaaactt cagttttact gcattttcac 7320 aacatatcag acttcaccaa atatatgcct tactattgta ttatagtact gctttactgt 7380 gtatctcaat aaagcacgca gttatgttac 7410 <210> 17 <211> 1225 <212> PRT <213> Homo sapiens <400> 17 Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn 1 5 10 15 Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val 20 25 30 Ile Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 35 40 45 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg Arg 50 55 60 Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn Lys 65 70 75 80 Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg 85 90 95 Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg 100 105 110 Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala 115 120 125 Lys Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu 130 135 140 Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile 145 150 155 160 Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn 165 170 175 Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr Ser 180 185 190 Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile Asn Ala 195 200 205 Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu 210 215 220 Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys 225 230 235 240 Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln 245 250 255 Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys 260 265 270 Glu Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 275 280 285 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg 290 295 300 Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp 305 310 315 320 Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile 325 330 335 Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu 340 345 350 Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu 355 360 365 Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln 370 375 380 Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro 385 390 395 400 Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln 405 410 415 Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro 420 425 430 Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala 435 440 445 Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp 450 455 460 Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln 465 470 475 480 Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile 485 490 495 Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln 500 505 510 Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 515 520 525 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr 530 535 540 Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu 545 550 555 560 Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg 565 570 575 Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe 580 585 590 Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn 595 600 605 Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp 610 615 620 His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 625 630 635 640 Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 645 650 655 Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 660 665 670 Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu 675 680 685 Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 690 695 700 His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn 705 710 715 720 Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val 725 730 735 Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu 740 745 750 Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 755 760 765 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 770 775 780 Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu 785 790 795 800 Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile 805 810 815 Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 820 825 830 Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys 835 840 845 His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 850 855 860 Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 865 870 875 880 Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 885 890 895 Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 900 905 910 Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys 915 920 925 His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 930 935 940 Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser 945 950 955 960 Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg 965 970 975 Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly 980 985 990 Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu 995 1000 1005 His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser 1010 1015 1020 Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu 1025 1030 1035 Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu 1040 1045 1050 Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys 1055 1060 1065 Gln Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro 1070 1075 1080 Glu Met Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu 1085 1090 1095 Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu 1100 1105 1110 Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser 1115 1120 1125 Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu 1130 1135 1140 Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr Ser Leu 1145 1150 1155 Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val Val Gly 1160 1165 1170 Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu Ser Pro 1175 1180 1185 Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln Leu 1190 1195 1200 Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys 1205 1210 1215 Pro Met Arg Glu Asp Thr Met 1220 1225 <210> 18 <211> 5623 <212> DNA <213> Homo sapiens <400> 18 gggttttctc aggattgcta tgcaacagga tcagtgctgt agtgcccggt tcaagctgaa 60 aatgttacac aggaagacat accatgtaaa ggacctccaa ggtgaaattg aagctcacac 120 agatgtttat cacaacctgg atgaaaacag ccaaaaaatc ctgagatccc tggaaggttc 180 cgatgatgca gtcctgttac aaagacgttt ggataacatg aacttcaagt ggagtgaact 240 tcggaaaaag tctctcaaca ttaggtccca tttggaagcc agttctgacc agtggaagcg 300 tctgcacctt tctctgcagg aacttctggt gtggctacag ctgaaagatg atgaattaag 360 ccggcaggca cctattggag gcgactttcc agcagttcag aagcagaacg atgtacatag 420 ggccttcaag agggaattga aaactaaaga acctgtaatc atgagtactc ttgagactgt 480 acgaatattt ctgacagagc agcctttgga aggactagag aaactctacc aggagcccag 540 agagctgcct cctgaggaga gagcccagaa tgtcactcgg cttctacgaa agcaggctga 600 ggaggtcaat actgagtggg aaaaattgaa cctgcactcc gctgactggc agagaaaaat 660 agatgagacc cttgaaagac tccaggaact tcaagaggcc acggatgagc tggacctcaa 720 gctgcgccaa gctgaggtga tcaagggatc ctggcagccc gtgggcgatc tcctcattga 780 ctctctccaa gatcacctcg agaaagtcaa ggcacttcga ggagaaattg cgcctctgaa 840 agagaacgtg agccacgtca atgaccttgc tcgccagctt accactttgg gcattcagct 900 ctcaccgtat aacctcagca ctctggaaga cctgaacacc agatggaagc ttctgcaggt 960 ggccgtcgag gaccgagtca ggcagctgca tgaagcccac agggactttg gtccagcatc 1020 tcagcacttt ctttccacgt ctgtccaggg tccctgggag agagccatct cgccaaacaa 1080 agtgccctac tatatcaacc acgagactca aacaacttgc tgggaccatc ccaaaatgac 1140 agagctctac cagtctttag ctgacctgaa taatgtcaga ttctcagctt ataggactgc 1200 catgaaactc cgaagactgc agaaggccct ttgcttggat ctcttgagcc tgtcagctgc 1260 atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac cagcccatgg atatcctgca 1320 gattattaat tgtttgacca ctatttatga ccgcctggag caagagcaca acaatttggt 1380 caacgtccct ctctgcgtgg atatgtgtct gaactggctg ctgaatgttt atgatacggg 1440 acgaacaggg aggatccgtg tcctgtcttt taaaactggc atcatttccc tgtgtaaagc 1500 acatttggaa gacaagtaca gatacctttt caagcaagtg gcaagttcaa caggattttg 1560 tgaccagcgc aggctgggcc tccttctgca tgattctatc caaattccaa gacagttggg 1620 tgaagttgca tcctttgggg gcagtaacat tgagccaagt gtccggagct gcttccaatt 1680 tgctaataat aagccagaga tcgaagcggc cctcttccta gactggatga gactggaacc 1740 ccagtccatg gtgtggctgc ccgtcctgca cagagtggct gctgcagaaa ctgccaagca 1800 tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt ggattcaggt acaggagtct 1860 aaagcacttt aattatgaca tctgccaaag ctgctttttt tctggtcgag ttgcaaaagg 1920 ccataaaatg cactatccca tggtggaata ttgcactccg actacatcag gagaagatgt 1980 tcgagacttt gccaaggtac taaaaaacaa atttcgaacc aaaaggtatt ttgcgaagca 2040 tccccgaatg ggctacctgc cagtgcagac tgtcttagag ggggacaaca tggaaactcc 2100 cgttactctg atcaacttct ggccagtaga ttctgcgcct gcctcgtccc ctcagctttc 2160 acacgatgat actcattcac gcattgaaca ttatgctagc aggctagcag aaatggaaaa 2220 cagcaatgga tcttatctaa atgatagcat ctctcctaat gagagcatag atgatgaaca 2280 tttgttaatc cagcattact gccaaagttt gaaccaggac tcccccctga gccagcctcg 2340 tagtcctgcc cagatcttga tttccttaga gagtgaggaa agaggggagc tagagagaat 2400 cctagcagat cttgaggaag aaaacaggaa tctgcaagca gaatatgacc gtctaaagca 2460 gcagcacgaa cataaaggcc tgtccccact gccgtcccct cctgaaatga tgcccacctc 2520 tccccagagt ccccgggatg ctgagctcat tgctgaggcc aagctactgc gtcaacacaa 2580 aggccgcctg gaagccagga tgcaaatcct ggaagaccac aataaacagc tggagtcaca 2640 gttacacagg ctaaggcagc tgctggagca accccaggca gaggccaaag tgaatggcac 2700 aacggtgtcc tctccttcta cctctctaca gaggtccgac agcagtcagc ctatgctgct 2760 ccgagtggtt ggcagtcaaa cttcggactc catgggtgag gaagatcttc tcagtcctcc 2820 ccaggacaca agcacagggt tagaggaggt gatggagcaa ctcaacaact ccttccctag 2880 ttcaagagga agaaataccc ctggaaagcc aatgagagag gacacaatgt aggaagtctt 2940 ttccacatgg cagatgattt gggcagagcg atggagtcct tagtatcagt catgacagat 3000 gaagaaggag cagaataaat gttttacaac tcctgattcc cgcatggttt ttataatatt 3060 catacaacaa agaggattag acagtaagag tttacaagaa ataaatctat atttttgtga 3120 agggtagtgg tattatactg tagatttcag tagtttctaa gtctgttatt gttttgttaa 3180 caatggcagg ttttacacgt ctatgcaatt gtacaaaaaa gttataagaa aactacatgt 3240 aaaatcttga tagctaaata acttgccatt tctttatatg gaacgcattt tgggttgttt 3300 aaaaatttat aacagttata aagaaagatt gtaaactaaa gtgtgcttta taaaaaaaag 3360 ttgtttataa aaacccctaa aaacaaaaca aacacacaca cacacacata cacacacaca 3420 cacaaaactt tgaggcagcg cattgttttg catccttttg gcgtgatatc catatgaaat 3480 tcatggcttt ttcttttttt gcatattaaa gataagactt cctctaccac cacaccaaat 3540 gactactaca cactgctcat ttgagaactg tcagctgagt ggggcaggct tgagttttca 3600 tttcatatat ctatatgtct ataagtatat aaatactata gttatataga taaagagata 3660 cgaatttcta tagactgact ttttccattt tttaaatgtt catgtcacat cctaatagaa 3720 agaaattact tctagtcagt catccaggct tacctgcttg gtctagaatg gatttttccc 3780 ggagccggaa gccaggagga aactacacca cactaaaaca ttgtctacag ctccagatgt 3840 ttctcatttt aaacaacttt ccactgacaa cgaaagtaaa gtaaagtatt ggattttttt 3900 aaagggaaca tgtgaatgaa tacacaggac ttattatatc agagtgagta atcggttggt 3960 tggttgattg attgattgat tgatacattc agcttcctgc tgctagcaat gccacgattt 4020 agatttaatg atgcttcagt ggaaatcaat cagaaggtat tctgaccttg tgaacatcag 4080 aaggtatttt ttaactccca agcagtagca ggacgatgat agggctggag ggctatggat 4140 tcccagccca tccctgtgaa ggagtaggcc actctttaag tgaaggattg gatgattgtt 4200 cataatacat aaagttctct gtaattacaa ctaaattatt atgccctctt ctcacagtca 4260 aaaggaactg ggtggtttgg tttttgttgc ttttttagat ttattgtccc atgtgggatg 4320 agtttttaaa tgccacaaga cataatttaa aataaataaa ctttgggaaa aggtgtaaaa 4380 cagtagcccc atcacatttg tgatactgac aggtatcaac ccagaagccc atgaactgtg 4440 tttccatcct ttgcatttct ctgcgagtag ttccacacag gtttgtaagt aagtaagaaa 4500 gaaggcaaat tgattcaaat gttacaaaaa aacccttctt ggtggattag acaggttaaa 4560 tatataaaca aacaaacaaa aattgctcaa aaaagaggag aaaagctcaa gaggaaaagc 4620 taaggactgg taggaaaaag ctttactctt tcatgccatt ttatttcttt ttgattttta 4680 aatcattcat tcaatagata ccaccgtgtg acctataatt ttgcaaatct gttacctctg 4740 acatcaagtg taattagctt ttggagagtg ggctgacatc aagtgtaatt agcttttgga 4800 gagtgggttt tgtccattat taataattaa ttaattaaca tcaaacacgg cttctcatgc 4860 tatttctacc tcactttggt tttggggtgt tcctgataat tgtgcacacc tgagttcaca 4920 gcttcaccac ttgtccattg cgttattttc tttttccttt ataattcttt ctttttcctt 4980 cataattttc aaaagaaaac ccaaagctct aaggtaacaa attaccaaat tacatgaaga 5040 tttggttttt gtcttgcatt tttttccttt atgtgacgct ggaccttttc tttacccaag 5100 gatttttaaa actcagattt aaaacaaggg gttactttac atcctactaa gaagtttaag 5160 taagtaagtt tcattctaaa atcagaggta aatagagtgc ataaataatt ttgttttaat 5220 ctttttgttt ttcttttaga cacattagct ctggagtgag tctgtcataa tatttgaaca 5280 aaaattgaga gctttattgc tgcattttaa gcataattaa tttggacatt atttcgtgtt 5340 gtgttcttta taaccaccaa gtattaaact gtaaatcata atgtaactga agcataaaca 5400 tcacatggca tgttttgtca ttgttttcag gtactgagtt cttacttgag tatcataata 5460 tattgtgttt taacaccaac actgtaacat ttacgaatta tttttttaaa cttcagtttt 5520 actgcatttt cacaacatat cagacttcac caaatatatg ccttactatt gtattatagt 5580 actgctttac tgtgtatctc aataaagcac gcagttatgt tac 5623 <210> 19 <211> 956 <212> PRT <213> Homo sapiens <400> 19 Met Leu His Arg Lys Thr Tyr His Val Lys Asp Leu Gln Gly Glu Ile 1 5 10 15 Glu Ala His Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys 20 25 30 Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg 35 40 45 Arg Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser 50 55 60 Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg 65 70 75 80 Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp 85 90 95 Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val 100 105 110 Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr 115 120 125 Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu 130 135 140 Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg 145 150 155 160 Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg 165 170 175 Lys Gln Ala Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His 180 185 190 Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln 195 200 205 Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala 210 215 220 Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp 225 230 235 240 Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile 245 250 255 Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln 260 265 270 Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu 275 280 285 Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 290 295 300 Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser 305 310 315 320 Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile 325 330 335 Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr 340 345 350 Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp 355 360 365 Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg 370 375 380 Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala 385 390 395 400 Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met 405 410 415 Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu 420 425 430 Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met 435 440 445 Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg 450 455 460 Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala 465 470 475 480 His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser 485 490 495 Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser 500 505 510 Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser 515 520 525 Asn Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys 530 535 540 Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro 545 550 555 560 Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu 565 570 575 Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile 580 585 590 Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys 595 600 605 Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His 610 615 620 Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val 625 630 635 640 Arg Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr 645 650 655 Phe Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu 660 665 670 Glu Gly Asp Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro 675 680 685 Val Asp Ser Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr 690 695 700 His Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn 705 710 715 720 Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile 725 730 735 Asp Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln 740 745 750 Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser 755 760 765 Leu Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu 770 775 780 Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln 785 790 795 800 Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met 805 810 815 Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu 820 825 830 Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln 835 840 845 Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu 850 855 860 Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr 865 870 875 880 Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln 885 890 895 Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly 900 905 910 Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu 915 920 925 Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg 930 935 940 Asn Thr Pro Gly Lys Pro Met Arg Glu Asp Thr Met 945 950 955 <210> 20 <211> 4623 <212> DNA <213> Homo sapiens <400> 20 actttcgggg agcccggcgg ctctgggaag ctcactcctc cactcgtacc cacactcgac 60 cgcggagccc ttgcagccat gagggaacag ctcaaaggcc acgagactca aacaacttgc 120 tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga 180 ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat 240 ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac 300 cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag 360 caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg 420 ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc 480 atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg 540 gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc 600 caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt 660 gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta 720 gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct 780 gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt 840 ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt 900 tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg 960 actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc 1020 aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag 1080 ggggacaaca tggaaactcc cgttactctg atcaacttct ggccagtaga ttctgcgcct 1140 gcctcgtccc ctcagctttc acacgatgat actcattcac gcattgaaca ttatgctagc 1200 aggctagcag aaatggaaaa cagcaatgga tcttatctaa atgatagcat ctctcctaat 1260 gagagcatag atgatgaaca tttgttaatc cagcattact gccaaagttt gaaccaggac 1320 tcccccctga gccagcctcg tagtcctgcc cagatcttga tttccttaga gagtgaggaa 1380 agaggggagc tagagagaat cctagcagat cttgaggaag aaaacaggaa tctgcaagca 1440 gaatatgacc gtctaaagca gcagcacgaa cataaaggcc tgtccccact gccgtcccct 1500 cctgaaatga tgcccacctc tccccagagt ccccgggatg ctgagctcat tgctgaggcc 1560 aagctactgc gtcaacacaa aggccgcctg gaagccagga tgcaaatcct ggaagaccac 1620 aataaacagc tggagtcaca gttacacagg ctaaggcagc tgctggagca accccaggca 1680 gaggccaaag tgaatggcac aacggtgtcc tctccttcta cctctctaca gaggtccgac 1740 agcagtcagc ctatgctgct ccgagtggtt ggcagtcaaa cttcggactc catgggtgag 1800 gaagatcttc tcagtcctcc ccaggacaca agcacagggt tagaggaggt gatggagcaa 1860 ctcaacaact ccttccctag ttcaagagga agaaataccc ctggaaagcc aatgagagag 1920 gacacaatgt aggaagtctt ttccacatgg cagatgattt gggcagagcg atggagtcct 1980 tagtatcagt catgacagat gaagaaggag cagaataaat gttttacaac tcctgattcc 2040 cgcatggttt ttataatatt catacaacaa agaggattag acagtaagag tttacaagaa 2100 ataaatctat atttttgtga agggtagtgg tattatactg tagatttcag tagtttctaa 2160 gtctgttatt gttttgttaa caatggcagg ttttacacgt ctatgcaatt gtacaaaaaa 2220 gttataagaa aactacatgt aaaatcttga tagctaaata acttgccatt tctttatatg 2280 gaacgcattt tgggttgttt aaaaatttat aacagttata aagaaagatt gtaaactaaa 2340 gtgtgcttta taaaaaaaag ttgtttataa aaacccctaa aaacaaaaca aacacacaca 2400 cacacacata cacacacaca cacaaaactt tgaggcagcg cattgttttg catccttttg 2460 gcgtgatatc catatgaaat tcatggcttt ttcttttttt gcatattaaa gataagactt 2520 cctctaccac cacaccaaat gactactaca cactgctcat ttgagaactg tcagctgagt 2580 ggggcaggct tgagttttca tttcatatat ctatatgtct ataagtatat aaatactata 2640 gttatataga taaagagata cgaatttcta tagactgact ttttccattt tttaaatgtt 2700 catgtcacat cctaatagaa agaaattact tctagtcagt catccaggct tacctgcttg 2760 gtctagaatg gatttttccc ggagccggaa gccaggagga aactacacca cactaaaaca 2820 ttgtctacag ctccagatgt ttctcatttt aaacaacttt ccactgacaa cgaaagtaaa 2880 gtaaagtatt ggattttttt aaagggaaca tgtgaatgaa tacacaggac ttattatatc 2940 agagtgagta atcggttggt tggttgattg attgattgat tgatacattc agcttcctgc 3000 tgctagcaat gccacgattt agatttaatg atgcttcagt ggaaatcaat cagaaggtat 3060 tctgaccttg tgaacatcag aaggtatttt ttaactccca agcagtagca ggacgatgat 3120 agggctggag ggctatggat tcccagccca tccctgtgaa ggagtaggcc actctttaag 3180 tgaaggattg gatgattgtt cataatacat aaagttctct gtaattacaa ctaaattatt 3240 atgccctctt ctcacagtca aaaggaactg ggtggtttgg tttttgttgc ttttttagat 3300 ttattgtccc atgtgggatg agtttttaaa tgccacaaga cataatttaa aataaataaa 3360 ctttgggaaa aggtgtaaaa cagtagcccc atcacatttg tgatactgac aggtatcaac 3420 ccagaagccc atgaactgtg tttccatcct ttgcatttct ctgcgagtag ttccacacag 3480 gtttgtaagt aagtaagaaa gaaggcaaat tgattcaaat gttacaaaaa aacccttctt 3540 ggtggattag acaggttaaa tatataaaca aacaaacaaa aattgctcaa aaaagaggag 3600 aaaagctcaa gaggaaaagc taaggactgg taggaaaaag ctttactctt tcatgccatt 3660 ttatttcttt ttgattttta aatcattcat tcaatagata ccaccgtgtg acctataatt 3720 ttgcaaatct gttacctctg acatcaagtg taattagctt ttggagagtg ggctgacatc 3780 aagtgtaatt agcttttgga gagtgggttt tgtccattat taataattaa ttaattaaca 3840 tcaaacacgg cttctcatgc tatttctacc tcactttggt tttggggtgt tcctgataat 3900 tgtgcacacc tgagttcaca gcttcaccac ttgtccattg cgttattttc tttttccttt 3960 ataattcttt ctttttcctt cataattttc aaaagaaaac ccaaagctct aaggtaacaa 4020 attaccaaat tacatgaaga tttggttttt gtcttgcatt tttttccttt atgtgacgct 4080 ggaccttttc tttacccaag gatttttaaa actcagattt aaaacaaggg gttactttac 4140 atcctactaa gaagtttaag taagtaagtt tcattctaaa atcagaggta aatagagtgc 4200 ataaataatt ttgttttaat ctttttgttt ttcttttaga cacattagct ctggagtgag 4260 tctgtcataa tatttgaaca aaaattgaga gctttattgc tgcattttaa gcataattaa 4320 tttggacatt atttcgtgtt gtgttcttta taaccaccaa gtattaaact gtaaatcata 4380 atgtaactga agcataaaca tcacatggca tgttttgtca ttgttttcag gtactgagtt 4440 cttacttgag tatcataata tattgtgttt taacaccaac actgtaacat ttacgaatta 4500 tttttttaaa cttcagtttt actgcatttt cacaacatat cagacttcac caaatatatg 4560 ccttactatt gtattatagt actgctttac tgtgtatctc aataaagcac gcagttatgt 4620 tac 4623 <210> 21 <211> 617 <212> PRT <213> Homo sapiens <400> 21 Met Arg Glu Gln Leu Lys Gly His Glu Thr Gln Thr Thr Cys Trp Asp 1 5 10 15 His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 20 25 30 Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 35 40 45 Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 50 55 60 Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu 65 70 75 80 Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 85 90 95 His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn 100 105 110 Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val 115 120 125 Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu 130 135 140 Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 145 150 155 160 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 165 170 175 Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu 180 185 190 Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile 195 200 205 Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 210 215 220 Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys 225 230 235 240 His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 245 250 255 Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 260 265 270 Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 275 280 285 Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 290 295 300 Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys 305 310 315 320 His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 325 330 335 Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser 340 345 350 Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg 355 360 365 Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly 370 375 380 Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu 385 390 395 400 His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro 405 410 415 Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser 420 425 430 Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu 435 440 445 Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu 450 455 460 His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr 465 470 475 480 Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu 485 490 495 Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu 500 505 510 Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu 515 520 525 Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser 530 535 540 Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu 545 550 555 560 Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp 565 570 575 Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met 580 585 590 Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro 595 600 605 Gly Lys Pro Met Arg Glu Asp Thr Met 610 615 <210> 22 <211> 4591 <212> DNA <213> Homo sapiens <400> 22 actttcgggg agcccggcgg ctctgggaag ctcactcctc cactcgtacc cacactcgac 60 cgcggagccc ttgcagccat gagggaacag ctcaaaggcc acgagactca aacaacttgc 120 tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga 180 ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat 240 ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac 300 cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag 360 caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg 420 ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc 480 atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg 540 gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc 600 caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt 660 gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta 720 gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct 780 gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt 840 ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt 900 tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg 960 actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc 1020 aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag 1080 ggggacaaca tggaaactcc cgttactctg atcaacttct ggccagtaga ttctgcgcct 1140 gcctcgtccc ctcagctttc acacgatgat actcattcac gcattgaaca ttatgctagc 1200 aggctagcag aaatggaaaa cagcaatgga tcttatctaa atgatagcat ctctcctaat 1260 gagagcatag atgatgaaca tttgttaatc cagcattact gccaaagttt gaaccaggac 1320 tcccccctga gccagcctcg tagtcctgcc cagatcttga tttccttaga gagtgaggaa 1380 agaggggagc tagagagaat cctagcagat cttgaggaag aaaacaggaa tctgcaagca 1440 gaatatgacc gtctaaagca gcagcacgaa cataaaggcc tgtccccact gccgtcccct 1500 cctgaaatga tgcccacctc tccccagagt ccccgggatg ctgagctcat tgctgaggcc 1560 aagctactgc gtcaacacaa aggccgcctg gaagccagga tgcaaatcct ggaagaccac 1620 aataaacagc tggagtcaca gttacacagg ctaaggcagc tgctggagca accccaggca 1680 gaggccaaag tgaatggcac aacggtgtcc tctccttcta cctctctaca gaggtccgac 1740 agcagtcagc ctatgctgct ccgagtggtt ggcagtcaaa cttcggactc catgggtgag 1800 gaagatcttc tcagtcctcc ccaggacaca agcacagggt tagaggaggt gatggagcaa 1860 ctcaacaact ccttccctag ttcaagagga cacaatgtag gaagtctttt ccacatggca 1920 gatgatttgg gcagagcgat ggagtcctta gtatcagtca tgacagatga agaaggagca 1980 gaataaatgt tttacaactc ctgattcccg catggttttt ataatattca tacaacaaag 2040 aggattagac agtaagagtt tacaagaaat aaatctatat ttttgtgaag ggtagtggta 2100 ttatactgta gatttcagta gtttctaagt ctgttattgt tttgttaaca atggcaggtt 2160 ttacacgtct atgcaattgt acaaaaaagt tataagaaaa ctacatgtaa aatcttgata 2220 gctaaataac ttgccatttc tttatatgga acgcattttg ggttgtttaa aaatttataa 2280 cagttataaa gaaagattgt aaactaaagt gtgctttata aaaaaaagtt gtttataaaa 2340 acccctaaaa acaaaacaaa cacacacaca cacacataca cacacacaca caaaactttg 2400 aggcagcgca ttgttttgca tccttttggc gtgatatcca tatgaaattc atggcttttt 2460 ctttttttgc atattaaaga taagacttcc tctaccacca caccaaatga ctactacaca 2520 ctgctcattt gagaactgtc agctgagtgg ggcaggcttg agttttcatt tcatatatct 2580 atatgtctat aagtatataa atactatagt tatatagata aagagatacg aatttctata 2640 gactgacttt ttccattttt taaatgttca tgtcacatcc taatagaaag aaattacttc 2700 tagtcagtca tccaggctta cctgcttggt ctagaatgga tttttcccgg agccggaagc 2760 caggaggaaa ctacaccaca ctaaaacatt gtctacagct ccagatgttt ctcattttaa 2820 acaactttcc actgacaacg aaagtaaagt aaagtattgg atttttttaa agggaacatg 2880 tgaatgaata cacaggactt attatatcag agtgagtaat cggttggttg gttgattgat 2940 tgattgattg atacattcag cttcctgctg ctagcaatgc cacgatttag atttaatgat 3000 gcttcagtgg aaatcaatca gaaggtattc tgaccttgtg aacatcagaa ggtatttttt 3060 aactcccaag cagtagcagg acgatgatag ggctggaggg ctatggattc ccagcccatc 3120 cctgtgaagg agtaggccac tctttaagtg aaggattgga tgattgttca taatacataa 3180 agttctctgt aattacaact aaattattat gccctcttct cacagtcaaa aggaactggg 3240 tggtttggtt tttgttgctt ttttagattt attgtcccat gtgggatgag tttttaaatg 3300 ccacaagaca taatttaaaa taaataaact ttgggaaaag gtgtaaaaca gtagccccat 3360 cacatttgtg atactgacag gtatcaaccc agaagcccat gaactgtgtt tccatccttt 3420 gcatttctct gcgagtagtt ccacacaggt ttgtaagtaa gtaagaaaga aggcaaattg 3480 attcaaatgt tacaaaaaaa cccttcttgg tggattagac aggttaaata tataaacaaa 3540 caaacaaaaa ttgctcaaaa aagaggagaa aagctcaaga ggaaaagcta aggactggta 3600 ggaaaaagct ttactctttc atgccatttt atttcttttt gatttttaaa tcattcattc 3660 aatagatacc accgtgtgac ctataatttt gcaaatctgt tacctctgac atcaagtgta 3720 attagctttt ggagagtggg ctgacatcaa gtgtaattag cttttggaga gtgggttttg 3780 tccattatta ataattaatt aattaacatc aaacacggct tctcatgcta tttctacctc 3840 actttggttt tggggtgttc ctgataattg tgcacacctg agttcacagc ttcaccactt 3900 gtccattgcg ttattttctt tttcctttat aattctttct ttttccttca taattttcaa 3960 aagaaaaccc aaagctctaa ggtaacaaat taccaaatta catgaagatt tggtttttgt 4020 cttgcatttt tttcctttat gtgacgctgg accttttctt tacccaagga tttttaaaac 4080 tcagatttaa aacaaggggt tactttacat cctactaaga agtttaagta agtaagtttc 4140 attctaaaat cagaggtaaa tagagtgcat aaataatttt gttttaatct ttttgttttt 4200 cttttagaca cattagctct ggagtgagtc tgtcataata tttgaacaaa aattgagagc 4260 tttattgctg cattttaagc ataattaatt tggacattat ttcgtgttgt gttctttata 4320 accaccaagt attaaactgt aaatcataat gtaactgaag cataaacatc acatggcatg 4380 ttttgtcatt gttttcaggt actgagttct tacttgagta tcataatata ttgtgtttta 4440 acaccaacac tgtaacattt acgaattatt tttttaaact tcagttttac tgcattttca 4500 caacatatca gacttcacca aatatatgcc ttactattgt attatagtac tgctttactg 4560 tgtatctcaa taaagcacgc agttatgtta c 4591 <210> 23 <211> 635 <212> PRT <213> Homo sapiens <400> 23 Met Arg Glu Gln Leu Lys Gly His Glu Thr Gln Thr Thr Cys Trp Asp 1 5 10 15 His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 20 25 30 Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 35 40 45 Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 50 55 60 Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu 65 70 75 80 Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 85 90 95 His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn 100 105 110 Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val 115 120 125 Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu 130 135 140 Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 145 150 155 160 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 165 170 175 Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu 180 185 190 Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile 195 200 205 Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 210 215 220 Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys 225 230 235 240 His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 245 250 255 Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 260 265 270 Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 275 280 285 Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 290 295 300 Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys 305 310 315 320 His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 325 330 335 Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser 340 345 350 Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg 355 360 365 Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly 370 375 380 Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu 385 390 395 400 His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro 405 410 415 Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser 420 425 430 Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu 435 440 445 Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu 450 455 460 His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr 465 470 475 480 Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu 485 490 495 Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu 500 505 510 Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu 515 520 525 Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser 530 535 540 Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu 545 550 555 560 Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp 565 570 575 Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met 580 585 590 Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly His Asn Val Gly 595 600 605 Ser Leu Phe His Met Ala Asp Asp Leu Gly Arg Ala Met Glu Ser Leu 610 615 620 Val Ser Val Met Thr Asp Glu Glu Gly Ala Glu 625 630 635 <210> 24 <211> 4584 <212> DNA <213> Homo sapiens <400> 24 actttcgggg agcccggcgg ctctgggaag ctcactcctc cactcgtacc cacactcgac 60 cgcggagccc ttgcagccat gagggaacag ctcaaaggcc acgagactca aacaacttgc 120 tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga 180 ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat 240 ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac 300 cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag 360 caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg 420 ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc 480 atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg 540 gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc 600 caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt 660 gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta 720 gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct 780 gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt 840 ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt 900 tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg 960 actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc 1020 aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag 1080 ggggacaaca tggaaacgcc tgcctcgtcc cctcagcttt cacacgatga tactcattca 1140 cgcattgaac attatgctag caggctagca gaaatggaaa acagcaatgg atcttatcta 1200 aatgatagca tctctcctaa tgagagcata gatgatgaac atttgttaat ccagcattac 1260 tgccaaagtt tgaaccagga ctcccccctg agccagcctc gtagtcctgc ccagatcttg 1320 atttccttag agagtgagga aagaggggag ctagagagaa tcctagcaga tcttgaggaa 1380 gaaaacagga atctgcaagc agaatatgac cgtctaaagc agcagcacga acataaaggc 1440 ctgtccccac tgccgtcccc tcctgaaatg atgcccacct ctccccagag tccccgggat 1500 gctgagctca ttgctgaggc caagctactg cgtcaacaca aaggccgcct ggaagccagg 1560 atgcaaatcc tggaagacca caataaacag ctggagtcac agttacacag gctaaggcag 1620 ctgctggagc aaccccaggc agaggccaaa gtgaatggca caacggtgtc ctctccttct 1680 acctctctac agaggtccga cagcagtcag cctatgctgc tccgagtggt tggcagtcaa 1740 acttcggact ccatgggtga ggaagatctt ctcagtcctc cccaggacac aagcacaggg 1800 ttagaggagg tgatggagca actcaacaac tccttcccta gttcaagagg aagaaatacc 1860 cctggaaagc caatgagaga ggacacaatg taggaagtct tttccacatg gcagatgatt 1920 tgggcagagc gatggagtcc ttagtatcag tcatgacaga tgaagaagga gcagaataaa 1980 tgttttacaa ctcctgattc ccgcatggtt tttataatat tcatacaaca aagaggatta 2040 gacagtaaga gtttacaaga aataaatcta tatttttgtg aagggtagtg gtattatact 2100 gtagatttca gtagtttcta agtctgttat tgttttgtta acaatggcag gttttacacg 2160 tctatgcaat tgtacaaaaa agttataaga aaactacatg taaaatcttg atagctaaat 2220 aacttgccat ttctttatat ggaacgcatt ttgggttgtt taaaaattta taacagttat 2280 aaagaaagat tgtaaactaa agtgtgcttt ataaaaaaaa gttgtttata aaaaccccta 2340 aaaacaaaac aaacacacac acacacacat acacacacac acacaaaact ttgaggcagc 2400 gcattgtttt gcatcctttt ggcgtgatat ccatatgaaa ttcatggctt tttctttttt 2460 tgcatattaa agataagact tcctctacca ccacaccaaa tgactactac acactgctca 2520 tttgagaact gtcagctgag tggggcaggc ttgagttttc atttcatata tctatatgtc 2580 tataagtata taaatactat agttatatag ataaagagat acgaatttct atagactgac 2640 tttttccatt ttttaaatgt tcatgtcaca tcctaataga aagaaattac ttctagtcag 2700 tcatccaggc ttacctgctt ggtctagaat ggatttttcc cggagccgga agccaggagg 2760 aaactacacc acactaaaac attgtctaca gctccagatg tttctcattt taaacaactt 2820 tccactgaca acgaaagtaa agtaaagtat tggatttttt taaagggaac atgtgaatga 2880 atacacagga cttattatat cagagtgagt aatcggttgg ttggttgatt gattgattga 2940 ttgatacatt cagcttcctg ctgctagcaa tgccacgatt tagatttaat gatgcttcag 3000 tggaaatcaa tcagaaggta ttctgacctt gtgaacatca gaaggtattt tttaactccc 3060 aagcagtagc aggacgatga tagggctgga gggctatgga ttcccagccc atccctgtga 3120 aggagtaggc cactctttaa gtgaaggatt ggatgattgt tcataataca taaagttctc 3180 tgtaattaca actaaattat tatgccctct tctcacagtc aaaaggaact gggtggtttg 3240 gtttttgttg cttttttaga tttattgtcc catgtgggat gagtttttaa atgccacaag 3300 acataattta aaataaataa actttgggaa aaggtgtaaa acagtagccc catcacattt 3360 gtgatactga caggtatcaa cccagaagcc catgaactgt gtttccatcc tttgcatttc 3420 tctgcgagta gttccacaca ggtttgtaag taagtaagaa agaaggcaaa ttgattcaaa 3480 tgttacaaaa aaacccttct tggtggatta gacaggttaa atatataaac aaacaaacaa 3540 aaattgctca aaaaagagga gaaaagctca agaggaaaag ctaaggactg gtaggaaaaa 3600 gctttactct ttcatgccat tttatttctt tttgattttt aaatcattca ttcaatagat 3660 accaccgtgt gacctataat tttgcaaatc tgttacctct gacatcaagt gtaattagct 3720 tttggagagt gggctgacat caagtgtaat tagcttttgg agagtgggtt ttgtccatta 3780 ttaataatta attaattaac atcaaacacg gcttctcatg ctatttctac ctcactttgg 3840 ttttggggtg ttcctgataa ttgtgcacac ctgagttcac agcttcacca cttgtccatt 3900 gcgttatttt ctttttcctt tataattctt tctttttcct tcataatttt caaaagaaaa 3960 cccaaagctc taaggtaaca aattaccaaa ttacatgaag atttggtttt tgtcttgcat 4020 ttttttcctt tatgtgacgc tggacctttt ctttacccaa ggatttttaa aactcagatt 4080 taaaacaagg ggttacttta catcctacta agaagtttaa gtaagtaagt ttcattctaa 4140 aatcagaggt aaatagagtg cataaataat tttgttttaa tctttttgtt tttcttttag 4200 acacattagc tctggagtga gtctgtcata atatttgaac aaaaattgag agctttattg 4260 ctgcatttta agcataatta atttggacat tatttcgtgt tgtgttcttt ataaccacca 4320 agtattaaac tgtaaatcat aatgtaactg aagcataaac atcacatggc atgttttgtc 4380 attgttttca ggtactgagt tcttacttga gtatcataat atattgtgtt ttaacaccaa 4440 cactgtaaca tttacgaatt atttttttaa acttcagttt tactgcattt tcacaacata 4500 tcagacttca ccaaatatat gccttactat tgtattatag tactgcttta ctgtgtatct 4560 caataaagca cgcagttatg ttac 4584 <210> 25 <211> 604 <212> PRT <213> Homo sapiens <400> 25 Met Arg Glu Gln Leu Lys Gly His Glu Thr Gln Thr Thr Cys Trp Asp 1 5 10 15 His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 20 25 30 Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 35 40 45 Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 50 55 60 Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu 65 70 75 80 Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 85 90 95 His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn 100 105 110 Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val 115 120 125 Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu 130 135 140 Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 145 150 155 160 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 165 170 175 Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu 180 185 190 Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile 195 200 205 Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 210 215 220 Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys 225 230 235 240 His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 245 250 255 Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 260 265 270 Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 275 280 285 Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 290 295 300 Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys 305 310 315 320 His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 325 330 335 Asn Met Glu Thr Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr 340 345 350 His Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn 355 360 365 Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile 370 375 380 Asp Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln 385 390 395 400 Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser 405 410 415 Leu Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu 420 425 430 Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln 435 440 445 Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met 450 455 460 Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu 465 470 475 480 Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln 485 490 495 Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu 500 505 510 Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr 515 520 525 Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln 530 535 540 Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly 545 550 555 560 Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu 565 570 575 Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg 580 585 590 Asn Thr Pro Gly Lys Pro Met Arg Glu Asp Thr Met 595 600 <210> 26 <211> 4552 <212> DNA <213> Homo sapiens <400> 26 actttcgggg agcccggcgg ctctgggaag ctcactcctc cactcgtacc cacactcgac 60 cgcggagccc ttgcagccat gagggaacag ctcaaaggcc acgagactca aacaacttgc 120 tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga 180 ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat 240 ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac 300 cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag 360 caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg 420 ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc 480 atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg 540 gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc 600 caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt 660 gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta 720 gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct 780 gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt 840 ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt 900 tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg 960 actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc 1020 aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag 1080 ggggacaaca tggaaacgcc tgcctcgtcc cctcagcttt cacacgatga tactcattca 1140 cgcattgaac attatgctag caggctagca gaaatggaaa acagcaatgg atcttatcta 1200 aatgatagca tctctcctaa tgagagcata gatgatgaac atttgttaat ccagcattac 1260 tgccaaagtt tgaaccagga ctcccccctg agccagcctc gtagtcctgc ccagatcttg 1320 atttccttag agagtgagga aagaggggag ctagagagaa tcctagcaga tcttgaggaa 1380 gaaaacagga atctgcaagc agaatatgac cgtctaaagc agcagcacga acataaaggc 1440 ctgtccccac tgccgtcccc tcctgaaatg atgcccacct ctccccagag tccccgggat 1500 gctgagctca ttgctgaggc caagctactg cgtcaacaca aaggccgcct ggaagccagg 1560 atgcaaatcc tggaagacca caataaacag ctggagtcac agttacacag gctaaggcag 1620 ctgctggagc aaccccaggc agaggccaaa gtgaatggca caacggtgtc ctctccttct 1680 acctctctac agaggtccga cagcagtcag cctatgctgc tccgagtggt tggcagtcaa 1740 acttcggact ccatgggtga ggaagatctt ctcagtcctc cccaggacac aagcacaggg 1800 ttagaggagg tgatggagca actcaacaac tccttcccta gttcaagagg acacaatgta 1860 ggaagtcttt tccacatggc agatgatttg ggcagagcga tggagtcctt agtatcagtc 1920 atgacagatg aagaaggagc agaataaatg ttttacaact cctgattccc gcatggtttt 1980 tataatattc atacaacaaa gaggattaga cagtaagagt ttacaagaaa taaatctata 2040 tttttgtgaa gggtagtggt attatactgt agatttcagt agtttctaag tctgttattg 2100 ttttgttaac aatggcaggt tttacacgtc tatgcaattg tacaaaaaag ttataagaaa 2160 actacatgta aaatcttgat agctaaataa cttgccattt ctttatatgg aacgcatttt 2220 gggttgttta aaaatttata acagttataa agaaagattg taaactaaag tgtgctttat 2280 aaaaaaaagt tgtttataaa aacccctaaa aacaaaacaa acacacacac acacacatac 2340 acacacacac acaaaacttt gaggcagcgc attgttttgc atccttttgg cgtgatatcc 2400 atatgaaatt catggctttt tctttttttg catattaaag ataagacttc ctctaccacc 2460 acaccaaatg actactacac actgctcatt tgagaactgt cagctgagtg gggcaggctt 2520 gagttttcat ttcatatatc tatatgtcta taagtatata aatactatag ttatatagat 2580 aaagagatac gaatttctat agactgactt tttccatttt ttaaatgttc atgtcacatc 2640 ctaatagaaa gaaattactt ctagtcagtc atccaggctt acctgcttgg tctagaatgg 2700 atttttcccg gagccggaag ccaggaggaa actacaccac actaaaacat tgtctacagc 2760 tccagatgtt tctcatttta aacaactttc cactgacaac gaaagtaaag taaagtattg 2820 gattttttta aagggaacat gtgaatgaat acacaggact tattatatca gagtgagtaa 2880 tcggttggtt ggttgattga ttgattgatt gatacattca gcttcctgct gctagcaatg 2940 ccacgattta gatttaatga tgcttcagtg gaaatcaatc agaaggtatt ctgaccttgt 3000 gaacatcaga aggtattttt taactcccaa gcagtagcag gacgatgata gggctggagg 3060 gctatggatt cccagcccat ccctgtgaag gagtaggcca ctctttaagt gaaggattgg 3120 atgattgttc ataatacata aagttctctg taattacaac taaattatta tgccctcttc 3180 tcacagtcaa aaggaactgg gtggtttggt ttttgttgct tttttagatt tattgtccca 3240 tgtgggatga gtttttaaat gccacaagac ataatttaaa ataaataaac tttgggaaaa 3300 ggtgtaaaac agtagcccca tcacatttgt gatactgaca ggtatcaacc cagaagccca 3360 tgaactgtgt ttccatcctt tgcatttctc tgcgagtagt tccacacagg tttgtaagta 3420 agtaagaaag aaggcaaatt gattcaaatg ttacaaaaaa acccttcttg gtggattaga 3480 caggttaaat atataaacaa acaaacaaaa attgctcaaa aaagaggaga aaagctcaag 3540 aggaaaagct aaggactggt aggaaaaagc tttactcttt catgccattt tatttctttt 3600 tgatttttaa atcattcatt caatagatac caccgtgtga cctataattt tgcaaatctg 3660 ttacctctga catcaagtgt aattagcttt tggagagtgg gctgacatca agtgtaatta 3720 gcttttggag agtgggtttt gtccattatt aataattaat taattaacat caaacacggc 3780 ttctcatgct atttctacct cactttggtt ttggggtgtt cctgataatt gtgcacacct 3840 gagttcacag cttcaccact tgtccattgc gttattttct ttttccttta taattctttc 3900 tttttccttc ataattttca aaagaaaacc caaagctcta aggtaacaaa ttaccaaatt 3960 acatgaagat ttggtttttg tcttgcattt ttttccttta tgtgacgctg gaccttttct 4020 ttacccaagg atttttaaaa ctcagattta aaacaagggg ttactttaca tcctactaag 4080 aagtttaagt aagtaagttt cattctaaaa tcagaggtaa atagagtgca taaataattt 4140 tgttttaatc tttttgtttt tcttttagac acattagctc tggagtgagt ctgtcataat 4200 atttgaacaa aaattgagag ctttattgct gcattttaag cataattaat ttggacatta 4260 tttcgtgttg tgttctttat aaccaccaag tattaaactg taaatcataa tgtaactgaa 4320 gcataaacat cacatggcat gttttgtcat tgttttcagg tactgagttc ttacttgagt 4380 atcataatat attgtgtttt aacaccaaca ctgtaacatt tacgaattat ttttttaaac 4440 ttcagtttta ctgcattttc acaacatatc agacttcacc aaatatatgc cttactattg 4500 tattatagta ctgctttact gtgtatctca ataaagcacg cagttatgtt ac 4552 <210> 27 <211> 622 <212> PRT <213> Homo sapiens <400> 27 Met Arg Glu Gln Leu Lys Gly His Glu Thr Gln Thr Thr Cys Trp Asp 1 5 10 15 His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 20 25 30 Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 35 40 45 Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 50 55 60 Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu 65 70 75 80 Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 85 90 95 His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn 100 105 110 Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val 115 120 125 Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu 130 135 140 Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 145 150 155 160 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 165 170 175 Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu 180 185 190 Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile 195 200 205 Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 210 215 220 Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys 225 230 235 240 His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 245 250 255 Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 260 265 270 Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 275 280 285 Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 290 295 300 Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys 305 310 315 320 His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 325 330 335 Asn Met Glu Thr Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr 340 345 350 His Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn 355 360 365 Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile 370 375 380 Asp Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln 385 390 395 400 Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser 405 410 415 Leu Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu 420 425 430 Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln 435 440 445 Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met 450 455 460 Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu 465 470 475 480 Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln 485 490 495 Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu 500 505 510 Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr 515 520 525 Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln 530 535 540 Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly 545 550 555 560 Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu 565 570 575 Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly His 580 585 590 Asn Val Gly Ser Leu Phe His Met Ala Asp Asp Leu Gly Arg Ala Met 595 600 605 Glu Ser Leu Val Ser Val Met Thr Asp Glu Glu Gly Ala Glu 610 615 620 <210> 28 <211> 1571 <212> DNA <213> Homo sapiens <400> 28 actttcgggg agcccggcgg ctctgggaag ctcactcctc cactcgtacc cacactcgac 60 cgcggagccc ttgcagccat gagggaacag ctcaaaggcc acgagactca aacaacttgc 120 tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa taatgtcaga 180 ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct ttgcttggat 240 ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa gcaaaatgac 300 cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga ccgcctggag 360 caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct gaactggctg 420 ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt taaaactggc 480 atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt caagcaagtg 540 gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca tgattctatc 600 caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat tgagccaagt 660 gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc cctcttccta 720 gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca cagagtggct 780 gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg tccaatcatt 840 ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag ctgctttttt 900 tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata ttgcactccg 960 actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc 1020 aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag 1080 ggggacaaca tggaaacgtg agtagtagca aaagcagaac acactcttgt ttgatgtata 1140 tttgaactcc tctcagctga acaccctcct tcactcccaa atgcaaacag tctcttctat 1200 ttctttcttt ttatttacat tagctgaaaa gagaaaaata agctgatgtc cagttgccac 1260 tttcccacgt cacttgacaa tttctttttc caaaagttaa actttatctc acagggggaa 1320 aaaaaaaaaa aaaccacaac acaatacagc cactaattgc cttacaagcc ttataagaaa 1380 tatgggactg tttacaaatg agtgattcca gtatttcatt ttgattttcc tctctcacaa 1440 atcagtaaat gtgtgtcttt ttgtatctca ttgtgtggtc atatctagtc acttgtttct 1500 actcaaaaga aaatatagtc acaggaaact acttcacagt aagtagtaat gattctcaag 1560 atcaaagggg a 1571 <210> 29 <211> 340 <212> PRT <213> Homo sapiens <400> 29 Met Arg Glu Gln Leu Lys Gly His Glu Thr Gln Thr Thr Cys Trp Asp 1 5 10 15 His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 20 25 30 Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 35 40 45 Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 50 55 60 Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu 65 70 75 80 Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 85 90 95 His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn 100 105 110 Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val 115 120 125 Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu 130 135 140 Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 145 150 155 160 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 165 170 175 Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu 180 185 190 Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile 195 200 205 Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 210 215 220 Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys 225 230 235 240 His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 245 250 255 Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 260 265 270 Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 275 280 285 Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 290 295 300 Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys 305 310 315 320 His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 325 330 335 Asn Met Glu Thr 340 <210> 30 <211> 7080 <212> DNA <213> Homo sapiens <400> 30 acactagcaa tggcaaagct ttgtgcggag gcattgctgg ctgctctgaa ctaaaagcat 60 ccgtggggac cgaaagaggt ttttgcacac cttattaagg aactccagga tggcattggg 120 cagcggcaaa ctgttgtcag aacattgaat gcaactgggg aagaaataat tcagcaatcc 180 tcaaaaacag atgccagtat tctacaggaa aaattgggaa gcctgaatct gcggtggcag 240 gaggtctgca aacagctgtc agacagaaaa aagaggctag aagaacaaaa gaatatcttg 300 tcagaatttc aaagagattt aaatgaattt gttttatggt tggaggaagc agataacatt 360 gctagtatcc cacttgaacc tggaaaagag cagcaactaa aagaaaagct tgagcaagtc 420 aagttactgg tggaagagtt gcccctgcgc cagggaattc tcaaacaatt aaatgaaact 480 ggaggacccg tgcttgtaag tgctcccata agcccagaag agcaagataa acttgaaaat 540 aagctcaagc agacaaatct ccagtggata aaggtttcca gagctttacc tgagaaacaa 600 ggagaaattg aagctcaaat aaaagacctt gggcagcttg aaaaaaagct tgaagacctt 660 gaagagcagt taaatcatct gctgctgtgg ttatctccta ttaggaatca gttggaaatt 720 tataaccaac caaaccaaga aggaccattt gacgttcagg aaactgaaat agcagttcaa 780 gctaaacaac cggatgtgga agagattttg tctaaagggc agcatttgta caaggaaaaa 840 ccagccactc agccagtgaa gaggaagtta gaagatctga gctctgagtg gaaggcggta 900 aaccgtttac ttcaagagct gagggcaaag cagcctgacc tagctcctgg actgaccact 960 attggagcct ctcctactca gactgttact ctggtgacac aacctgtggt tactaaggaa 1020 actgccatct ccaaactaga aatgccatct tccttgatgt tggaggtacc tgctctggca 1080 gatttcaacc gggcttggac agaacttacc gactggcttt ctctgcttga tcaagttata 1140 aaatcacaga gggtgatggt gggtgacctt gaggatatca acgagatgat catcaagcag 1200 aaggcaacaa tgcaggattt ggaacagagg cgtccccagt tggaagaact cattaccgct 1260 gcccaaaatt tgaaaaacaa gaccagcaat caagaggcta gaacaatcat tacggatcga 1320 attgaaagaa ttcagaatca gtgggatgaa gtacaagaac accttcagaa ccggaggcaa 1380 cagttgaatg aaatgttaaa ggattcaaca caatggctgg aagctaagga agaagctgag 1440 caggtcttag gacaggccag agccaagctt gagtcatgga aggagggtcc ctatacagta 1500 gatgcaatcc aaaagaaaat cacagaaacc aagcagttgg ccaaagacct ccgccagtgg 1560 cagacaaatg tagatgtggc aaatgacttg gccctgaaac ttctccggga ttattctgca 1620 gatgatacca gaaaagtcca catgataaca gagaatatca atgcctcttg gagaagcatt 1680 cataaaaggg tgagtgagcg agaggctgct ttggaagaaa ctcatagatt actgcaacag 1740 ttccccctgg acctggaaaa gtttcttgcc tggcttacag aagctgaaac aactgccaat 1800 gtcctacagg atgctacccg taaggaaagg ctcctagaag actccaaggg agtaaaagag 1860 ctgatgaaac aatggcaaga cctccaaggt gaaattgaag ctcacacaga tgtttatcac 1920 aacctggatg aaaacagcca aaaaatcctg agatccctgg aaggttccga tgatgcagtc 1980 ctgttacaaa gacgtttgga taacatgaac ttcaagtgga gtgaacttcg gaaaaagtct 2040 ctcaacatta ggtcccattt ggaagccagt tctgaccagt ggaagcgtct gcacctttct 2100 ctgcaggaac ttctggtgtg gctacagctg aaagatgatg aattaagccg gcaggcacct 2160 attggaggcg actttccagc agttcagaag cagaacgatg tacatagggc cttcaagagg 2220 gaattgaaaa ctaaagaacc tgtaatcatg agtactcttg agactgtacg aatatttctg 2280 acagagcagc ctttggaagg actagagaaa ctctaccagg agcccagaga gctgcctcct 2340 gaggagagag cccagaatgt cactcggctt ctacgaaagc aggctgagga ggtcaatact 2400 gagtgggaaa aattgaacct gcactccgct gactggcaga gaaaaataga tgagaccctt 2460 gaaagactcc aggaacttca agaggccacg gatgagctgg acctcaagct gcgccaagct 2520 gaggtgatca agggatcctg gcagcccgtg ggcgatctcc tcattgactc tctccaagat 2580 cacctcgaga aagtcaaggc acttcgagga gaaattgcgc ctctgaaaga gaacgtgagc 2640 cacgtcaatg accttgctcg ccagcttacc actttgggca ttcagctctc accgtataac 2700 ctcagcactc tggaagacct gaacaccaga tggaagcttc tgcaggtggc cgtcgaggac 2760 cgagtcaggc agctgcatga agcccacagg gactttggtc cagcatctca gcactttctt 2820 tccacgtctg tccagggtcc ctgggagaga gccatctcgc caaacaaagt gccctactat 2880 atcaaccacg agactcaaac aacttgctgg gaccatccca aaatgacaga gctctaccag 2940 tctttagctg acctgaataa tgtcagattc tcagcttata ggactgccat gaaactccga 3000 agactgcaga aggccctttg cttggatctc ttgagcctgt cagctgcatg tgatgccttg 3060 gaccagcaca acctcaagca aaatgaccag cccatggata tcctgcagat tattaattgt 3120 ttgaccacta tttatgaccg cctggagcaa gagcacaaca atttggtcaa cgtccctctc 3180 tgcgtggata tgtgtctgaa ctggctgctg aatgtttatg atacgggacg aacagggagg 3240 atccgtgtcc tgtcttttaa aactggcatc atttccctgt gtaaagcaca tttggaagac 3300 aagtacagat accttttcaa gcaagtggca agttcaacag gattttgtga ccagcgcagg 3360 ctgggcctcc ttctgcatga ttctatccaa attccaagac agttgggtga agttgcatcc 3420 tttgggggca gtaacattga gccaagtgtc cggagctgct tccaatttgc taataataag 3480 ccagagatcg aagcggccct cttcctagac tggatgagac tggaacccca gtccatggtg 3540 tggctgcccg tcctgcacag agtggctgct gcagaaactg ccaagcatca ggccaaatgt 3600 aacatctgca aagagtgtcc aatcattgga ttcaggtaca ggagtctaaa gcactttaat 3660 tatgacatct gccaaagctg ctttttttct ggtcgagttg caaaaggcca taaaatgcac 3720 tatcccatgg tggaatattg cactccgact acatcaggag aagatgttcg agactttgcc 3780 aaggtactaa aaaacaaatt tcgaaccaaa aggtattttg cgaagcatcc ccgaatgggc 3840 tacctgccag tgcagactgt cttagagggg gacaacatgg aaacgaatct gcaagcagaa 3900 tatgaccgtc taaagcagca gcacgaacat aaaggcctgt ccccactgcc gtcccctcct 3960 gaaatgatgc ccacctctcc ccagagtccc cgggatgctg agctcattgc tgaggccaag 4020 ctactgcgtc aacacaaagg ccgcctggaa gccaggatgc aaatcctgga agaccacaat 4080 aaacagctgg agtcacagtt acacaggcta aggcagctgc tggagcaacc ccaggcagag 4140 gccaaagtga atggcacaac ggtgtcctct ccttctacct ctctacagag gtccgacagc 4200 agtcagccta tgctgctccg agtggttggc agtcaaactt cggactccat gggtgaggaa 4260 gatcttctca gtcctcccca ggacacaagc acagggttag aggaggtgat ggagcaactc 4320 aacaactcct tccctagttc aagaggaaga aatacccctg gaaagccaat gagagaggac 4380 acaatgtagg aagtcttttc cacatggcag atgatttggg cagagcgatg gagtccttag 4440 tatcagtcat gacagatgaa gaaggagcag aataaatgtt ttacaactcc tgattcccgc 4500 atggttttta taatattcat acaacaaaga ggattagaca gtaagagttt acaagaaata 4560 aatctatatt tttgtgaagg gtagtggtat tatactgtag atttcagtag tttctaagtc 4620 tgttattgtt ttgttaacaa tggcaggttt tacacgtcta tgcaattgta caaaaaagtt 4680 ataagaaaac tacatgtaaa atcttgatag ctaaataact tgccatttct ttatatggaa 4740 cgcattttgg gttgtttaaa aatttataac agttataaag aaagattgta aactaaagtg 4800 tgctttataa aaaaaagttg tttataaaaa cccctaaaaa caaaacaaac acacacacac 4860 acacatacac acacacacac aaaactttga ggcagcgcat tgttttgcat ccttttggcg 4920 tgatatccat atgaaattca tggctttttc tttttttgca tattaaagat aagacttcct 4980 ctaccaccac accaaatgac tactacacac tgctcatttg agaactgtca gctgagtggg 5040 gcaggcttga gttttcattt catatatcta tatgtctata agtatataaa tactatagtt 5100 atatagataa agagatacga atttctatag actgactttt tccatttttt aaatgttcat 5160 gtcacatcct aatagaaaga aattacttct agtcagtcat ccaggcttac ctgcttggtc 5220 tagaatggat ttttcccgga gccggaagcc aggaggaaac tacaccacac taaaacattg 5280 tctacagctc cagatgtttc tcattttaaa caactttcca ctgacaacga aagtaaagta 5340 aagtattgga tttttttaaa gggaacatgt gaatgaatac acaggactta ttatatcaga 5400 gtgagtaatc ggttggttgg ttgattgatt gattgattga tacattcagc ttcctgctgc 5460 tagcaatgcc acgatttaga tttaatgatg cttcagtgga aatcaatcag aaggtattct 5520 gaccttgtga acatcagaag gtatttttta actcccaagc agtagcagga cgatgatagg 5580 gctggagggc tatggattcc cagcccatcc ctgtgaagga gtaggccact ctttaagtga 5640 aggattggat gattgttcat aatacataaa gttctctgta attacaacta aattattatg 5700 ccctcttctc acagtcaaaa ggaactgggt ggtttggttt ttgttgcttt tttagattta 5760 ttgtcccatg tgggatgagt ttttaaatgc cacaagacat aatttaaaat aaataaactt 5820 tgggaaaagg tgtaaaacag tagccccatc acatttgtga tactgacagg tatcaaccca 5880 gaagcccatg aactgtgttt ccatcctttg catttctctg cgagtagttc cacacaggtt 5940 tgtaagtaag taagaaagaa ggcaaattga ttcaaatgtt acaaaaaaac ccttcttggt 6000 ggattagaca ggttaaatat ataaacaaac aaacaaaaat tgctcaaaaa agaggagaaa 6060 agctcaagag gaaaagctaa ggactggtag gaaaaagctt tactctttca tgccatttta 6120 tttctttttg atttttaaat cattcattca atagatacca ccgtgtgacc tataattttg 6180 caaatctgtt acctctgaca tcaagtgtaa ttagcttttg gagagtgggc tgacatcaag 6240 tgtaattagc ttttggagag tgggttttgt ccattattaa taattaatta attaacatca 6300 aacacggctt ctcatgctat ttctacctca ctttggtttt ggggtgttcc tgataattgt 6360 gcacacctga gttcacagct tcaccacttg tccattgcgt tattttcttt ttcctttata 6420 attctttctt tttccttcat aattttcaaa agaaaaccca aagctctaag gtaacaaatt 6480 accaaattac atgaagattt ggtttttgtc ttgcattttt ttcctttatg tgacgctgga 6540 ccttttcttt acccaaggat ttttaaaact cagatttaaa acaaggggtt actttacatc 6600 ctactaagaa gtttaagtaa gtaagtttca ttctaaaatc agaggtaaat agagtgcata 6660 aataattttg ttttaatctt tttgtttttc ttttagacac attagctctg gagtgagtct 6720 gtcataatat ttgaacaaaa attgagagct ttattgctgc attttaagca taattaattt 6780 ggacattatt tcgtgttgtg ttctttataa ccaccaagta ttaaactgta aatcataatg 6840 taactgaagc ataaacatca catggcatgt tttgtcattg ttttcaggta ctgagttctt 6900 acttgagtat cataatatat tgtgttttaa caccaacact gtaacattta cgaattattt 6960 ttttaaactt cagttttact gcattttcac aacatatcag acttcaccaa atatatgcct 7020 tactattgta ttatagtact gctttactgt gtatctcaat aaagcacgca gttatgttac 7080 <210> 31 <211> 1115 <212> PRT <213> Homo sapiens <400> 31 Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn 1 5 10 15 Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val 20 25 30 Ile Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 35 40 45 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg Arg 50 55 60 Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn Lys 65 70 75 80 Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg 85 90 95 Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg 100 105 110 Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala 115 120 125 Lys Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu 130 135 140 Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile 145 150 155 160 Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn 165 170 175 Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr Ser 180 185 190 Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile Asn Ala 195 200 205 Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu 210 215 220 Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys 225 230 235 240 Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln 245 250 255 Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys 260 265 270 Glu Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 275 280 285 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg 290 295 300 Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp 305 310 315 320 Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile 325 330 335 Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu 340 345 350 Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu 355 360 365 Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln 370 375 380 Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro 385 390 395 400 Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln 405 410 415 Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro 420 425 430 Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala 435 440 445 Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp 450 455 460 Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln 465 470 475 480 Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile 485 490 495 Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln 500 505 510 Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 515 520 525 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr 530 535 540 Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu 545 550 555 560 Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg 565 570 575 Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe 580 585 590 Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn 595 600 605 Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp 610 615 620 His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 625 630 635 640 Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 645 650 655 Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 660 665 670 Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu 675 680 685 Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 690 695 700 His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn 705 710 715 720 Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val 725 730 735 Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu 740 745 750 Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 755 760 765 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 770 775 780 Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu 785 790 795 800 Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile 805 810 815 Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 820 825 830 Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys 835 840 845 His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 850 855 860 Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 865 870 875 880 Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 885 890 895 Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 900 905 910 Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys 915 920 925 His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 930 935 940 Asn Met Glu Thr Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln 945 950 955 960 His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met 965 970 975 Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala 980 985 990 Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile 995 1000 1005 Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu 1010 1015 1020 Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly 1025 1030 1035 Thr Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser 1040 1045 1050 Ser Gln Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp 1055 1060 1065 Ser Met Gly Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser 1070 1075 1080 Thr Gly Leu Glu Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro 1085 1090 1095 Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys Pro Met Arg Glu Asp 1100 1105 1110 Thr Met 1115 <210> 32 <211> 7378 <212> DNA <213> Homo sapiens <400> 32 acactagcaa tggcaaagct ttgtgcggag gcattgctgg ctgctctgaa ctaaaagcat 60 ccgtggggac cgaaagaggt ttttgcacac cttattaagg aactccagga tggcattggg 120 cagcggcaaa ctgttgtcag aacattgaat gcaactgggg aagaaataat tcagcaatcc 180 tcaaaaacag atgccagtat tctacaggaa aaattgggaa gcctgaatct gcggtggcag 240 gaggtctgca aacagctgtc agacagaaaa aagaggctag aagaacaaaa gaatatcttg 300 tcagaatttc aaagagattt aaatgaattt gttttatggt tggaggaagc agataacatt 360 gctagtatcc cacttgaacc tggaaaagag cagcaactaa aagaaaagct tgagcaagtc 420 aagttactgg tggaagagtt gcccctgcgc cagggaattc tcaaacaatt aaatgaaact 480 ggaggacccg tgcttgtaag tgctcccata agcccagaag agcaagataa acttgaaaat 540 aagctcaagc agacaaatct ccagtggata aaggtttcca gagctttacc tgagaaacaa 600 ggagaaattg aagctcaaat aaaagacctt gggcagcttg aaaaaaagct tgaagacctt 660 gaagagcagt taaatcatct gctgctgtgg ttatctccta ttaggaatca gttggaaatt 720 tataaccaac caaaccaaga aggaccattt gacgttcagg aaactgaaat agcagttcaa 780 gctaaacaac cggatgtgga agagattttg tctaaagggc agcatttgta caaggaaaaa 840 ccagccactc agccagtgaa gaggaagtta gaagatctga gctctgagtg gaaggcggta 900 aaccgtttac ttcaagagct gagggcaaag cagcctgacc tagctcctgg actgaccact 960 attggagcct ctcctactca gactgttact ctggtgacac aacctgtggt tactaaggaa 1020 actgccatct ccaaactaga aatgccatct tccttgatgt tggaggtacc tgctctggca 1080 gatttcaacc gggcttggac agaacttacc gactggcttt ctctgcttga tcaagttata 1140 aaatcacaga gggtgatggt gggtgacctt gaggatatca acgagatgat catcaagcag 1200 aaggcaacaa tgcaggattt ggaacagagg cgtccccagt tggaagaact cattaccgct 1260 gcccaaaatt tgaaaaacaa gaccagcaat caagaggcta gaacaatcat tacggatcga 1320 attgaaagaa ttcagaatca gtgggatgaa gtacaagaac accttcagaa ccggaggcaa 1380 cagttgaatg aaatgttaaa ggattcaaca caatggctgg aagctaagga agaagctgag 1440 caggtcttag gacaggccag agccaagctt gagtcatgga aggagggtcc ctatacagta 1500 gatgcaatcc aaaagaaaat cacagaaacc aagcagttgg ccaaagacct ccgccagtgg 1560 cagacaaatg tagatgtggc aaatgacttg gccctgaaac ttctccggga ttattctgca 1620 gatgatacca gaaaagtcca catgataaca gagaatatca atgcctcttg gagaagcatt 1680 cataaaaggg tgagtgagcg agaggctgct ttggaagaaa ctcatagatt actgcaacag 1740 ttccccctgg acctggaaaa gtttcttgcc tggcttacag aagctgaaac aactgccaat 1800 gtcctacagg atgctacccg taaggaaagg ctcctagaag actccaaggg agtaaaagag 1860 ctgatgaaac aatggcaaga cctccaaggt gaaattgaag ctcacacaga tgtttatcac 1920 aacctggatg aaaacagcca aaaaatcctg agatccctgg aaggttccga tgatgcagtc 1980 ctgttacaaa gacgtttgga taacatgaac ttcaagtgga gtgaacttcg gaaaaagtct 2040 ctcaacatta ggtcccattt ggaagccagt tctgaccagt ggaagcgtct gcacctttct 2100 ctgcaggaac ttctggtgtg gctacagctg aaagatgatg aattaagccg gcaggcacct 2160 attggaggcg actttccagc agttcagaag cagaacgatg tacatagggc cttcaagagg 2220 gaattgaaaa ctaaagaacc tgtaatcatg agtactcttg agactgtacg aatatttctg 2280 acagagcagc ctttggaagg actagagaaa ctctaccagg agcccagaga gctgcctcct 2340 gaggagagag cccagaatgt cactcggctt ctacgaaagc aggctgagga ggtcaatact 2400 gagtgggaaa aattgaacct gcactccgct gactggcaga gaaaaataga tgagaccctt 2460 gaaagactcc aggaacttca agaggccacg gatgagctgg acctcaagct gcgccaagct 2520 gaggtgatca agggatcctg gcagcccgtg ggcgatctcc tcattgactc tctccaagat 2580 cacctcgaga aagtcaaggc acttcgagga gaaattgcgc ctctgaaaga gaacgtgagc 2640 cacgtcaatg accttgctcg ccagcttacc actttgggca ttcagctctc accgtataac 2700 ctcagcactc tggaagacct gaacaccaga tggaagcttc tgcaggtggc cgtcgaggac 2760 cgagtcaggc agctgcatga agcccacagg gactttggtc cagcatctca gcactttctt 2820 tccacgtctg tccagggtcc ctgggagaga gccatctcgc caaacaaagt gccctactat 2880 atcaaccacg agactcaaac aacttgctgg gaccatccca aaatgacaga gctctaccag 2940 tctttagctg acctgaataa tgtcagattc tcagcttata ggactgccat gaaactccga 3000 agactgcaga aggccctttg cttggatctc ttgagcctgt cagctgcatg tgatgccttg 3060 gaccagcaca acctcaagca aaatgaccag cccatggata tcctgcagat tattaattgt 3120 ttgaccacta tttatgaccg cctggagcaa gagcacaaca atttggtcaa cgtccctctc 3180 tgcgtggata tgtgtctgaa ctggctgctg aatgtttatg atacgggacg aacagggagg 3240 atccgtgtcc tgtcttttaa aactggcatc atttccctgt gtaaagcaca tttggaagac 3300 aagtacagat accttttcaa gcaagtggca agttcaacag gattttgtga ccagcgcagg 3360 ctgggcctcc ttctgcatga ttctatccaa attccaagac agttgggtga agttgcatcc 3420 tttgggggca gtaacattga gccaagtgtc cggagctgct tccaatttgc taataataag 3480 ccagagatcg aagcggccct cttcctagac tggatgagac tggaacccca gtccatggtg 3540 tggctgcccg tcctgcacag agtggctgct gcagaaactg ccaagcatca ggccaaatgt 3600 aacatctgca aagagtgtcc aatcattgga ttcaggtaca ggagtctaaa gcactttaat 3660 tatgacatct gccaaagctg ctttttttct ggtcgagttg caaaaggcca taaaatgcac 3720 tatcccatgg tggaatattg cactccgact acatcaggag aagatgttcg agactttgcc 3780 aaggtactaa aaaacaaatt tcgaaccaaa aggtattttg cgaagcatcc ccgaatgggc 3840 tacctgccag tgcagactgt cttagagggg gacaacatgg aaactcccgt tactctgatc 3900 aacttctggc cagtagattc tgcgcctgcc tcgtcccctc agctttcaca cgatgatact 3960 cattcacgca ttgaacatta tgctagcagg ctagcagaaa tggaaaacag caatggatct 4020 tatctaaatg atagcatctc tcctaatgag agcatagatg atgaacattt gttaatccag 4080 cattactgcc aaagtttgaa ccaggactcc cccctgagcc agcctcgtag tcctgcccag 4140 atcttgattt ccttagagag tgaggaaaga ggggagctag agagaatcct agcagatctt 4200 gaggaagaaa acaggaatct gcaagcagaa tatgaccgtc taaagcagca gcacgaacat 4260 aaaggcctgt ccccactgcc gtcccctcct gaaatgatgc ccacctctcc ccagagtccc 4320 cgggatgctg agctcattgc tgaggccaag ctactgcgtc aacacaaagg ccgcctggaa 4380 gccaggatgc aaatcctgga agaccacaat aaacagctgg agtcacagtt acacaggcta 4440 aggcagctgc tggagcaacc ccaggcagag gccaaagtga atggcacaac ggtgtcctct 4500 ccttctacct ctctacagag gtccgacagc agtcagccta tgctgctccg agtggttggc 4560 agtcaaactt cggactccat gggtgaggaa gatcttctca gtcctcccca ggacacaagc 4620 acagggttag aggaggtgat ggagcaactc aacaactcct tccctagttc aagaggacac 4680 aatgtaggaa gtcttttcca catggcagat gatttgggca gagcgatgga gtccttagta 4740 tcagtcatga cagatgaaga aggagcagaa taaatgtttt acaactcctg attcccgcat 4800 ggtttttata atattcatac aacaaagagg attagacagt aagagtttac aagaaataaa 4860 tctatatttt tgtgaagggt agtggtatta tactgtagat ttcagtagtt tctaagtctg 4920 ttattgtttt gttaacaatg gcaggtttta cacgtctatg caattgtaca aaaaagttat 4980 aagaaaacta catgtaaaat cttgatagct aaataacttg ccatttcttt atatggaacg 5040 cattttgggt tgtttaaaaa tttataacag ttataaagaa agattgtaaa ctaaagtgtg 5100 ctttataaaa aaaagttgtt tataaaaacc cctaaaaaca aaacaaacac acacacacac 5160 acatacacac acacacacaa aactttgagg cagcgcattg ttttgcatcc ttttggcgtg 5220 atatccatat gaaattcatg gctttttctt tttttgcata ttaaagataa gacttcctct 5280 accaccacac caaatgacta ctacacactg ctcatttgag aactgtcagc tgagtggggc 5340 aggcttgagt tttcatttca tatatctata tgtctataag tatataaata ctatagttat 5400 atagataaag agatacgaat ttctatagac tgactttttc cattttttaa atgttcatgt 5460 cacatcctaa tagaaagaaa ttacttctag tcagtcatcc aggcttacct gcttggtcta 5520 gaatggattt ttcccggagc cggaagccag gaggaaacta caccacacta aaacattgtc 5580 tacagctcca gatgtttctc attttaaaca actttccact gacaacgaaa gtaaagtaaa 5640 gtattggatt tttttaaagg gaacatgtga atgaatacac aggacttatt atatcagagt 5700 gagtaatcgg ttggttggtt gattgattga ttgattgata cattcagctt cctgctgcta 5760 gcaatgccac gatttagatt taatgatgct tcagtggaaa tcaatcagaa ggtattctga 5820 ccttgtgaac atcagaaggt attttttaac tcccaagcag tagcaggacg atgatagggc 5880 tggagggcta tggattccca gcccatccct gtgaaggagt aggccactct ttaagtgaag 5940 gattggatga ttgttcataa tacataaagt tctctgtaat tacaactaaa ttattatgcc 6000 ctcttctcac agtcaaaagg aactgggtgg tttggttttt gttgcttttt tagatttatt 6060 gtcccatgtg ggatgagttt ttaaatgcca caagacataa tttaaaataa ataaactttg 6120 ggaaaaggtg taaaacagta gccccatcac atttgtgata ctgacaggta tcaacccaga 6180 agcccatgaa ctgtgtttcc atcctttgca tttctctgcg agtagttcca cacaggtttg 6240 taagtaagta agaaagaagg caaattgatt caaatgttac aaaaaaaccc ttcttggtgg 6300 attagacagg ttaaatatat aaacaaacaa acaaaaattg ctcaaaaaag aggagaaaag 6360 ctcaagagga aaagctaagg actggtagga aaaagcttta ctctttcatg ccattttatt 6420 tctttttgat ttttaaatca ttcattcaat agataccacc gtgtgaccta taattttgca 6480 aatctgttac ctctgacatc aagtgtaatt agcttttgga gagtgggctg acatcaagtg 6540 taattagctt ttggagagtg ggttttgtcc attattaata attaattaat taacatcaaa 6600 cacggcttct catgctattt ctacctcact ttggttttgg ggtgttcctg ataattgtgc 6660 acacctgagt tcacagcttc accacttgtc cattgcgtta ttttcttttt cctttataat 6720 tctttctttt tccttcataa ttttcaaaag aaaacccaaa gctctaaggt aacaaattac 6780 caaattacat gaagatttgg tttttgtctt gcattttttt cctttatgtg acgctggacc 6840 ttttctttac ccaaggattt ttaaaactca gatttaaaac aaggggttac tttacatcct 6900 actaagaagt ttaagtaagt aagtttcatt ctaaaatcag aggtaaatag agtgcataaa 6960 taattttgtt ttaatctttt tgtttttctt ttagacacat tagctctgga gtgagtctgt 7020 cataatattt gaacaaaaat tgagagcttt attgctgcat tttaagcata attaatttgg 7080 acattatttc gtgttgtgtt ctttataacc accaagtatt aaactgtaaa tcataatgta 7140 actgaagcat aaacatcaca tggcatgttt tgtcattgtt ttcaggtact gagttcttac 7200 ttgagtatca taatatattg tgttttaaca ccaacactgt aacatttacg aattattttt 7260 ttaaacttca gttttactgc attttcacaa catatcagac ttcaccaaat atatgcctta 7320 ctattgtatt atagtactgc tttactgtgt atctcaataa agcacgcagt tatgttac 7378 <210> 33 <211> 1243 <212> PRT <213> Homo sapiens <400> 33 Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn 1 5 10 15 Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val 20 25 30 Ile Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 35 40 45 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg Arg 50 55 60 Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn Lys 65 70 75 80 Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg 85 90 95 Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg 100 105 110 Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala 115 120 125 Lys Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu 130 135 140 Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile 145 150 155 160 Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn 165 170 175 Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr Ser 180 185 190 Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile Asn Ala 195 200 205 Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu 210 215 220 Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys 225 230 235 240 Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln 245 250 255 Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys 260 265 270 Glu Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 275 280 285 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg 290 295 300 Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp 305 310 315 320 Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile 325 330 335 Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu 340 345 350 Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu 355 360 365 Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln 370 375 380 Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro 385 390 395 400 Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln 405 410 415 Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro 420 425 430 Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala 435 440 445 Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp 450 455 460 Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln 465 470 475 480 Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile 485 490 495 Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln 500 505 510 Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 515 520 525 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr 530 535 540 Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu 545 550 555 560 Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg 565 570 575 Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe 580 585 590 Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn 595 600 605 Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp 610 615 620 His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 625 630 635 640 Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 645 650 655 Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 660 665 670 Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu 675 680 685 Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 690 695 700 His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn 705 710 715 720 Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val 725 730 735 Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu 740 745 750 Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 755 760 765 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 770 775 780 Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu 785 790 795 800 Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile 805 810 815 Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 820 825 830 Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys 835 840 845 His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 850 855 860 Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 865 870 875 880 Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 885 890 895 Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 900 905 910 Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys 915 920 925 His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 930 935 940 Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser 945 950 955 960 Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg 965 970 975 Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly 980 985 990 Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu 995 1000 1005 His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser 1010 1015 1020 Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu 1025 1030 1035 Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu 1040 1045 1050 Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys 1055 1060 1065 Gln Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro 1070 1075 1080 Glu Met Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu 1085 1090 1095 Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu 1100 1105 1110 Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser 1115 1120 1125 Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu 1130 1135 1140 Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr Ser Leu 1145 1150 1155 Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val Val Gly 1160 1165 1170 Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu Ser Pro 1175 1180 1185 Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln Leu 1190 1195 1200 Asn Asn Ser Phe Pro Ser Ser Arg Gly His Asn Val Gly Ser Leu 1205 1210 1215 Phe His Met Ala Asp Asp Leu Gly Arg Ala Met Glu Ser Leu Val 1220 1225 1230 Ser Val Met Thr Asp Glu Glu Gly Ala Glu 1235 1240 <210> 34 <211> 7339 <212> DNA <213> Homo sapiens <400> 34 acactagcaa tggcaaagct ttgtgcggag gcattgctgg ctgctctgaa ctaaaagcat 60 ccgtggggac cgaaagaggt ttttgcacac cttattaagg aactccagga tggcattggg 120 cagcggcaaa ctgttgtcag aacattgaat gcaactgggg aagaaataat tcagcaatcc 180 tcaaaaacag atgccagtat tctacaggaa aaattgggaa gcctgaatct gcggtggcag 240 gaggtctgca aacagctgtc agacagaaaa aagaggctag aagaacaaaa gaatatcttg 300 tcagaatttc aaagagattt aaatgaattt gttttatggt tggaggaagc agataacatt 360 gctagtatcc cacttgaacc tggaaaagag cagcaactaa aagaaaagct tgagcaagtc 420 aagttactgg tggaagagtt gcccctgcgc cagggaattc tcaaacaatt aaatgaaact 480 ggaggacccg tgcttgtaag tgctcccata agcccagaag agcaagataa acttgaaaat 540 aagctcaagc agacaaatct ccagtggata aaggtttcca gagctttacc tgagaaacaa 600 ggagaaattg aagctcaaat aaaagacctt gggcagcttg aaaaaaagct tgaagacctt 660 gaagagcagt taaatcatct gctgctgtgg ttatctccta ttaggaatca gttggaaatt 720 tataaccaac caaaccaaga aggaccattt gacgttcagg aaactgaaat agcagttcaa 780 gctaaacaac cggatgtgga agagattttg tctaaagggc agcatttgta caaggaaaaa 840 ccagccactc agccagtgaa gaggaagtta gaagatctga gctctgagtg gaaggcggta 900 aaccgtttac ttcaagagct gagggcaaag cagcctgacc tagctcctgg actgaccact 960 attggagcct ctcctactca gactgttact ctggtgacac aacctgtggt tactaaggaa 1020 actgccatct ccaaactaga aatgccatct tccttgatgt tggaggtacc tgctctggca 1080 gatttcaacc gggcttggac agaacttacc gactggcttt ctctgcttga tcaagttata 1140 aaatcacaga gggtgatggt gggtgacctt gaggatatca acgagatgat catcaagcag 1200 aaggcaacaa tgcaggattt ggaacagagg cgtccccagt tggaagaact cattaccgct 1260 gcccaaaatt tgaaaaacaa gaccagcaat caagaggcta gaacaatcat tacggatcga 1320 attgaaagaa ttcagaatca gtgggatgaa gtacaagaac accttcagaa ccggaggcaa 1380 cagttgaatg aaatgttaaa ggattcaaca caatggctgg aagctaagga agaagctgag 1440 caggtcttag gacaggccag agccaagctt gagtcatgga aggagggtcc ctatacagta 1500 gatgcaatcc aaaagaaaat cacagaaacc aagcagttgg ccaaagacct ccgccagtgg 1560 cagacaaatg tagatgtggc aaatgacttg gccctgaaac ttctccggga ttattctgca 1620 gatgatacca gaaaagtcca catgataaca gagaatatca atgcctcttg gagaagcatt 1680 cataaaaggg tgagtgagcg agaggctgct ttggaagaaa ctcatagatt actgcaacag 1740 ttccccctgg acctggaaaa gtttcttgcc tggcttacag aagctgaaac aactgccaat 1800 gtcctacagg atgctacccg taaggaaagg ctcctagaag actccaaggg agtaaaagag 1860 ctgatgaaac aatggcaaga cctccaaggt gaaattgaag ctcacacaga tgtttatcac 1920 aacctggatg aaaacagcca aaaaatcctg agatccctgg aaggttccga tgatgcagtc 1980 ctgttacaaa gacgtttgga taacatgaac ttcaagtgga gtgaacttcg gaaaaagtct 2040 ctcaacatta ggtcccattt ggaagccagt tctgaccagt ggaagcgtct gcacctttct 2100 ctgcaggaac ttctggtgtg gctacagctg aaagatgatg aattaagccg gcaggcacct 2160 attggaggcg actttccagc agttcagaag cagaacgatg tacatagggc cttcaagagg 2220 gaattgaaaa ctaaagaacc tgtaatcatg agtactcttg agactgtacg aatatttctg 2280 acagagcagc ctttggaagg actagagaaa ctctaccagg agcccagaga gctgcctcct 2340 gaggagagag cccagaatgt cactcggctt ctacgaaagc aggctgagga ggtcaatact 2400 gagtgggaaa aattgaacct gcactccgct gactggcaga gaaaaataga tgagaccctt 2460 gaaagactcc aggaacttca agaggccacg gatgagctgg acctcaagct gcgccaagct 2520 gaggtgatca agggatcctg gcagcccgtg ggcgatctcc tcattgactc tctccaagat 2580 cacctcgaga aagtcaaggc acttcgagga gaaattgcgc ctctgaaaga gaacgtgagc 2640 cacgtcaatg accttgctcg ccagcttacc actttgggca ttcagctctc accgtataac 2700 ctcagcactc tggaagacct gaacaccaga tggaagcttc tgcaggtggc cgtcgaggac 2760 cgagtcaggc agctgcatga agcccacagg gactttggtc cagcatctca gcactttctt 2820 tccacgtctg tccagggtcc ctgggagaga gccatctcgc caaacaaagt gccctactat 2880 atcaaccacg agactcaaac aacttgctgg gaccatccca aaatgacaga gctctaccag 2940 tctttagctg acctgaataa tgtcagattc tcagcttata ggactgccat gaaactccga 3000 agactgcaga aggccctttg cttggatctc ttgagcctgt cagctgcatg tgatgccttg 3060 gaccagcaca acctcaagca aaatgaccag cccatggata tcctgcagat tattaattgt 3120 ttgaccacta tttatgaccg cctggagcaa gagcacaaca atttggtcaa cgtccctctc 3180 tgcgtggata tgtgtctgaa ctggctgctg aatgtttatg atacgggacg aacagggagg 3240 atccgtgtcc tgtcttttaa aactggcatc atttccctgt gtaaagcaca tttggaagac 3300 aagtacagat accttttcaa gcaagtggca agttcaacag gattttgtga ccagcgcagg 3360 ctgggcctcc ttctgcatga ttctatccaa attccaagac agttgggtga agttgcatcc 3420 tttgggggca gtaacattga gccaagtgtc cggagctgct tccaatttgc taataataag 3480 ccagagatcg aagcggccct cttcctagac tggatgagac tggaacccca gtccatggtg 3540 tggctgcccg tcctgcacag agtggctgct gcagaaactg ccaagcatca ggccaaatgt 3600 aacatctgca aagagtgtcc aatcattgga ttcaggtaca ggagtctaaa gcactttaat 3660 tatgacatct gccaaagctg ctttttttct ggtcgagttg caaaaggcca taaaatgcac 3720 tatcccatgg tggaatattg cactccgact acatcaggag aagatgttcg agactttgcc 3780 aaggtactaa aaaacaaatt tcgaaccaaa aggtattttg cgaagcatcc ccgaatgggc 3840 tacctgccag tgcagactgt cttagagggg gacaacatgg aaacgcctgc ctcgtcccct 3900 cagctttcac acgatgatac tcattcacgc attgaacatt atgctagcag gctagcagaa 3960 atggaaaaca gcaatggatc ttatctaaat gatagcatct ctcctaatga gagcatagat 4020 gatgaacatt tgttaatcca gcattactgc caaagtttga accaggactc ccccctgagc 4080 cagcctcgta gtcctgccca gatcttgatt tccttagaga gtgaggaaag aggggagcta 4140 gagagaatcc tagcagatct tgaggaagaa aacaggaatc tgcaagcaga atatgaccgt 4200 ctaaagcagc agcacgaaca taaaggcctg tccccactgc cgtcccctcc tgaaatgatg 4260 cccacctctc cccagagtcc ccgggatgct gagctcattg ctgaggccaa gctactgcgt 4320 caacacaaag gccgcctgga agccaggatg caaatcctgg aagaccacaa taaacagctg 4380 gagtcacagt tacacaggct aaggcagctg ctggagcaac cccaggcaga ggccaaagtg 4440 aatggcacaa cggtgtcctc tccttctacc tctctacaga ggtccgacag cagtcagcct 4500 atgctgctcc gagtggttgg cagtcaaact tcggactcca tgggtgagga agatcttctc 4560 agtcctcccc aggacacaag cacagggtta gaggaggtga tggagcaact caacaactcc 4620 ttccctagtt caagaggaca caatgtagga agtcttttcc acatggcaga tgatttgggc 4680 agagcgatgg agtccttagt atcagtcatg acagatgaag aaggagcaga ataaatgttt 4740 tacaactcct gattcccgca tggtttttat aatattcata caacaaagag gattagacag 4800 taagagttta caagaaataa atctatattt ttgtgaaggg tagtggtatt atactgtaga 4860 tttcagtagt ttctaagtct gttattgttt tgttaacaat ggcaggtttt acacgtctat 4920 gcaattgtac aaaaaagtta taagaaaact acatgtaaaa tcttgatagc taaataactt 4980 gccatttctt tatatggaac gcattttggg ttgtttaaaa atttataaca gttataaaga 5040 aagattgtaa actaaagtgt gctttataaa aaaaagttgt ttataaaaac ccctaaaaac 5100 aaaacaaaca cacacacaca cacatacaca cacacacaca aaactttgag gcagcgcatt 5160 gttttgcatc cttttggcgt gatatccata tgaaattcat ggctttttct ttttttgcat 5220 attaaagata agacttcctc taccaccaca ccaaatgact actacacact gctcatttga 5280 gaactgtcag ctgagtgggg caggcttgag ttttcatttc atatatctat atgtctataa 5340 gtatataaat actatagtta tatagataaa gagatacgaa tttctataga ctgacttttt 5400 ccatttttta aatgttcatg tcacatccta atagaaagaa attacttcta gtcagtcatc 5460 caggcttacc tgcttggtct agaatggatt tttcccggag ccggaagcca ggaggaaact 5520 acaccacact aaaacattgt ctacagctcc agatgtttct cattttaaac aactttccac 5580 tgacaacgaa agtaaagtaa agtattggat ttttttaaag ggaacatgtg aatgaataca 5640 caggacttat tatatcagag tgagtaatcg gttggttggt tgattgattg attgattgat 5700 acattcagct tcctgctgct agcaatgcca cgatttagat ttaatgatgc ttcagtggaa 5760 atcaatcaga aggtattctg accttgtgaa catcagaagg tattttttaa ctcccaagca 5820 gtagcaggac gatgataggg ctggagggct atggattccc agcccatccc tgtgaaggag 5880 taggccactc tttaagtgaa ggattggatg attgttcata atacataaag ttctctgtaa 5940 ttacaactaa attattatgc cctcttctca cagtcaaaag gaactgggtg gtttggtttt 6000 tgttgctttt ttagatttat tgtcccatgt gggatgagtt tttaaatgcc acaagacata 6060 atttaaaata aataaacttt gggaaaaggt gtaaaacagt agccccatca catttgtgat 6120 actgacaggt atcaacccag aagcccatga actgtgtttc catcctttgc atttctctgc 6180 gagtagttcc acacaggttt gtaagtaagt aagaaagaag gcaaattgat tcaaatgtta 6240 caaaaaaacc cttcttggtg gattagacag gttaaatata taaacaaaca aacaaaaatt 6300 gctcaaaaaa gaggagaaaa gctcaagagg aaaagctaag gactggtagg aaaaagcttt 6360 actctttcat gccattttat ttctttttga tttttaaatc attcattcaa tagataccac 6420 cgtgtgacct ataattttgc aaatctgtta cctctgacat caagtgtaat tagcttttgg 6480 agagtgggct gacatcaagt gtaattagct tttggagagt gggttttgtc cattattaat 6540 aattaattaa ttaacatcaa acacggcttc tcatgctatt tctacctcac tttggttttg 6600 gggtgttcct gataattgtg cacacctgag ttcacagctt caccacttgt ccattgcgtt 6660 attttctttt tcctttataa ttctttcttt ttccttcata attttcaaaa gaaaacccaa 6720 agctctaagg taacaaatta ccaaattaca tgaagatttg gtttttgtct tgcatttttt 6780 tcctttatgt gacgctggac cttttcttta cccaaggatt tttaaaactc agatttaaaa 6840 caaggggtta ctttacatcc tactaagaag tttaagtaag taagtttcat tctaaaatca 6900 gaggtaaata gagtgcataa ataattttgt tttaatcttt ttgtttttct tttagacaca 6960 ttagctctgg agtgagtctg tcataatatt tgaacaaaaa ttgagagctt tattgctgca 7020 ttttaagcat aattaatttg gacattattt cgtgttgtgt tctttataac caccaagtat 7080 taaactgtaa atcataatgt aactgaagca taaacatcac atggcatgtt ttgtcattgt 7140 tttcaggtac tgagttctta cttgagtatc ataatatatt gtgttttaac accaacactg 7200 taacatttac gaattatttt tttaaacttc agttttactg cattttcaca acatatcaga 7260 cttcaccaaa tatatgcctt actattgtat tatagtactg ctttactgtg tatctcaata 7320 aagcacgcag ttatgttac 7339 <210> 35 <211> 1230 <212> PRT <213> Homo sapiens <400> 35 Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn 1 5 10 15 Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val 20 25 30 Ile Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 35 40 45 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg Arg 50 55 60 Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn Lys 65 70 75 80 Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg 85 90 95 Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg 100 105 110 Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala 115 120 125 Lys Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu 130 135 140 Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile 145 150 155 160 Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn 165 170 175 Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr Ser 180 185 190 Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile Asn Ala 195 200 205 Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu 210 215 220 Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys 225 230 235 240 Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln 245 250 255 Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys 260 265 270 Glu Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 275 280 285 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg 290 295 300 Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp 305 310 315 320 Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile 325 330 335 Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu 340 345 350 Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu 355 360 365 Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln 370 375 380 Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro 385 390 395 400 Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln 405 410 415 Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro 420 425 430 Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala 435 440 445 Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp 450 455 460 Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln 465 470 475 480 Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile 485 490 495 Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln 500 505 510 Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 515 520 525 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr 530 535 540 Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu 545 550 555 560 Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg 565 570 575 Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe 580 585 590 Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn 595 600 605 Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp 610 615 620 His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 625 630 635 640 Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 645 650 655 Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 660 665 670 Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu 675 680 685 Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 690 695 700 His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn 705 710 715 720 Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val 725 730 735 Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu 740 745 750 Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 755 760 765 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 770 775 780 Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu 785 790 795 800 Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile 805 810 815 Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 820 825 830 Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys 835 840 845 His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 850 855 860 Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 865 870 875 880 Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 885 890 895 Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 900 905 910 Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys 915 920 925 His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 930 935 940 Asn Met Glu Thr Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr 945 950 955 960 His Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn 965 970 975 Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile 980 985 990 Asp Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln 995 1000 1005 Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile 1010 1015 1020 Ser Leu Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala 1025 1030 1035 Asp Leu Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg 1040 1045 1050 Leu Lys Gln Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser 1055 1060 1065 Pro Pro Glu Met Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala 1070 1075 1080 Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg 1085 1090 1095 Leu Glu Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu 1100 1105 1110 Glu Ser Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro Gln 1115 1120 1125 Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr 1130 1135 1140 Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val 1145 1150 1155 Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu 1160 1165 1170 Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu 1175 1180 1185 Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly His Asn Val Gly 1190 1195 1200 Ser Leu Phe His Met Ala Asp Asp Leu Gly Arg Ala Met Glu Ser 1205 1210 1215 Leu Val Ser Val Met Thr Asp Glu Glu Gly Ala Glu 1220 1225 1230 <210> 36 <211> 7048 <212> DNA <213> Homo sapiens <400> 36 acactagcaa tggcaaagct ttgtgcggag gcattgctgg ctgctctgaa ctaaaagcat 60 ccgtggggac cgaaagaggt ttttgcacac cttattaagg aactccagga tggcattggg 120 cagcggcaaa ctgttgtcag aacattgaat gcaactgggg aagaaataat tcagcaatcc 180 tcaaaaacag atgccagtat tctacaggaa aaattgggaa gcctgaatct gcggtggcag 240 gaggtctgca aacagctgtc agacagaaaa aagaggctag aagaacaaaa gaatatcttg 300 tcagaatttc aaagagattt aaatgaattt gttttatggt tggaggaagc agataacatt 360 gctagtatcc cacttgaacc tggaaaagag cagcaactaa aagaaaagct tgagcaagtc 420 aagttactgg tggaagagtt gcccctgcgc cagggaattc tcaaacaatt aaatgaaact 480 ggaggacccg tgcttgtaag tgctcccata agcccagaag agcaagataa acttgaaaat 540 aagctcaagc agacaaatct ccagtggata aaggtttcca gagctttacc tgagaaacaa 600 ggagaaattg aagctcaaat aaaagacctt gggcagcttg aaaaaaagct tgaagacctt 660 gaagagcagt taaatcatct gctgctgtgg ttatctccta ttaggaatca gttggaaatt 720 tataaccaac caaaccaaga aggaccattt gacgttcagg aaactgaaat agcagttcaa 780 gctaaacaac cggatgtgga agagattttg tctaaagggc agcatttgta caaggaaaaa 840 ccagccactc agccagtgaa gaggaagtta gaagatctga gctctgagtg gaaggcggta 900 aaccgtttac ttcaagagct gagggcaaag cagcctgacc tagctcctgg actgaccact 960 attggagcct ctcctactca gactgttact ctggtgacac aacctgtggt tactaaggaa 1020 actgccatct ccaaactaga aatgccatct tccttgatgt tggaggtacc tgctctggca 1080 gatttcaacc gggcttggac agaacttacc gactggcttt ctctgcttga tcaagttata 1140 aaatcacaga gggtgatggt gggtgacctt gaggatatca acgagatgat catcaagcag 1200 aaggcaacaa tgcaggattt ggaacagagg cgtccccagt tggaagaact cattaccgct 1260 gcccaaaatt tgaaaaacaa gaccagcaat caagaggcta gaacaatcat tacggatcga 1320 attgaaagaa ttcagaatca gtgggatgaa gtacaagaac accttcagaa ccggaggcaa 1380 cagttgaatg aaatgttaaa ggattcaaca caatggctgg aagctaagga agaagctgag 1440 caggtcttag gacaggccag agccaagctt gagtcatgga aggagggtcc ctatacagta 1500 gatgcaatcc aaaagaaaat cacagaaacc aagcagttgg ccaaagacct ccgccagtgg 1560 cagacaaatg tagatgtggc aaatgacttg gccctgaaac ttctccggga ttattctgca 1620 gatgatacca gaaaagtcca catgataaca gagaatatca atgcctcttg gagaagcatt 1680 cataaaaggg tgagtgagcg agaggctgct ttggaagaaa ctcatagatt actgcaacag 1740 ttccccctgg acctggaaaa gtttcttgcc tggcttacag aagctgaaac aactgccaat 1800 gtcctacagg atgctacccg taaggaaagg ctcctagaag actccaaggg agtaaaagag 1860 ctgatgaaac aatggcaaga cctccaaggt gaaattgaag ctcacacaga tgtttatcac 1920 aacctggatg aaaacagcca aaaaatcctg agatccctgg aaggttccga tgatgcagtc 1980 ctgttacaaa gacgtttgga taacatgaac ttcaagtgga gtgaacttcg gaaaaagtct 2040 ctcaacatta ggtcccattt ggaagccagt tctgaccagt ggaagcgtct gcacctttct 2100 ctgcaggaac ttctggtgtg gctacagctg aaagatgatg aattaagccg gcaggcacct 2160 attggaggcg actttccagc agttcagaag cagaacgatg tacatagggc cttcaagagg 2220 gaattgaaaa ctaaagaacc tgtaatcatg agtactcttg agactgtacg aatatttctg 2280 acagagcagc ctttggaagg actagagaaa ctctaccagg agcccagaga gctgcctcct 2340 gaggagagag cccagaatgt cactcggctt ctacgaaagc aggctgagga ggtcaatact 2400 gagtgggaaa aattgaacct gcactccgct gactggcaga gaaaaataga tgagaccctt 2460 gaaagactcc aggaacttca agaggccacg gatgagctgg acctcaagct gcgccaagct 2520 gaggtgatca agggatcctg gcagcccgtg ggcgatctcc tcattgactc tctccaagat 2580 cacctcgaga aagtcaaggc acttcgagga gaaattgcgc ctctgaaaga gaacgtgagc 2640 cacgtcaatg accttgctcg ccagcttacc actttgggca ttcagctctc accgtataac 2700 ctcagcactc tggaagacct gaacaccaga tggaagcttc tgcaggtggc cgtcgaggac 2760 cgagtcaggc agctgcatga agcccacagg gactttggtc cagcatctca gcactttctt 2820 tccacgtctg tccagggtcc ctgggagaga gccatctcgc caaacaaagt gccctactat 2880 atcaaccacg agactcaaac aacttgctgg gaccatccca aaatgacaga gctctaccag 2940 tctttagctg acctgaataa tgtcagattc tcagcttata ggactgccat gaaactccga 3000 agactgcaga aggccctttg cttggatctc ttgagcctgt cagctgcatg tgatgccttg 3060 gaccagcaca acctcaagca aaatgaccag cccatggata tcctgcagat tattaattgt 3120 ttgaccacta tttatgaccg cctggagcaa gagcacaaca atttggtcaa cgtccctctc 3180 tgcgtggata tgtgtctgaa ctggctgctg aatgtttatg atacgggacg aacagggagg 3240 atccgtgtcc tgtcttttaa aactggcatc atttccctgt gtaaagcaca tttggaagac 3300 aagtacagat accttttcaa gcaagtggca agttcaacag gattttgtga ccagcgcagg 3360 ctgggcctcc ttctgcatga ttctatccaa attccaagac agttgggtga agttgcatcc 3420 tttgggggca gtaacattga gccaagtgtc cggagctgct tccaatttgc taataataag 3480 ccagagatcg aagcggccct cttcctagac tggatgagac tggaacccca gtccatggtg 3540 tggctgcccg tcctgcacag agtggctgct gcagaaactg ccaagcatca ggccaaatgt 3600 aacatctgca aagagtgtcc aatcattgga ttcaggtaca ggagtctaaa gcactttaat 3660 tatgacatct gccaaagctg ctttttttct ggtcgagttg caaaaggcca taaaatgcac 3720 tatcccatgg tggaatattg cactccgact acatcaggag aagatgttcg agactttgcc 3780 aaggtactaa aaaacaaatt tcgaaccaaa aggtattttg cgaagcatcc ccgaatgggc 3840 tacctgccag tgcagactgt cttagagggg gacaacatgg aaacgaatct gcaagcagaa 3900 tatgaccgtc taaagcagca gcacgaacat aaaggcctgt ccccactgcc gtcccctcct 3960 gaaatgatgc ccacctctcc ccagagtccc cgggatgctg agctcattgc tgaggccaag 4020 ctactgcgtc aacacaaagg ccgcctggaa gccaggatgc aaatcctgga agaccacaat 4080 aaacagctgg agtcacagtt acacaggcta aggcagctgc tggagcaacc ccaggcagag 4140 gccaaagtga atggcacaac ggtgtcctct ccttctacct ctctacagag gtccgacagc 4200 agtcagccta tgctgctccg agtggttggc agtcaaactt cggactccat gggtgaggaa 4260 gatcttctca gtcctcccca ggacacaagc acagggttag aggaggtgat ggagcaactc 4320 aacaactcct tccctagttc aagaggacac aatgtaggaa gtcttttcca catggcagat 4380 gatttgggca gagcgatgga gtccttagta tcagtcatga cagatgaaga aggagcagaa 4440 taaatgtttt acaactcctg attcccgcat ggtttttata atattcatac aacaaagagg 4500 attagacagt aagagtttac aagaaataaa tctatatttt tgtgaagggt agtggtatta 4560 tactgtagat ttcagtagtt tctaagtctg ttattgtttt gttaacaatg gcaggtttta 4620 cacgtctatg caattgtaca aaaaagttat aagaaaacta catgtaaaat cttgatagct 4680 aaataacttg ccatttcttt atatggaacg cattttgggt tgtttaaaaa tttataacag 4740 ttataaagaa agattgtaaa ctaaagtgtg ctttataaaa aaaagttgtt tataaaaacc 4800 cctaaaaaca aaacaaacac acacacacac acatacacac acacacacaa aactttgagg 4860 cagcgcattg ttttgcatcc ttttggcgtg atatccatat gaaattcatg gctttttctt 4920 tttttgcata ttaaagataa gacttcctct accaccacac caaatgacta ctacacactg 4980 ctcatttgag aactgtcagc tgagtggggc aggcttgagt tttcatttca tatatctata 5040 tgtctataag tatataaata ctatagttat atagataaag agatacgaat ttctatagac 5100 tgactttttc cattttttaa atgttcatgt cacatcctaa tagaaagaaa ttacttctag 5160 tcagtcatcc aggcttacct gcttggtcta gaatggattt ttcccggagc cggaagccag 5220 gaggaaacta caccacacta aaacattgtc tacagctcca gatgtttctc attttaaaca 5280 actttccact gacaacgaaa gtaaagtaaa gtattggatt tttttaaagg gaacatgtga 5340 atgaatacac aggacttatt atatcagagt gagtaatcgg ttggttggtt gattgattga 5400 ttgattgata cattcagctt cctgctgcta gcaatgccac gatttagatt taatgatgct 5460 tcagtggaaa tcaatcagaa ggtattctga ccttgtgaac atcagaaggt attttttaac 5520 tcccaagcag tagcaggacg atgatagggc tggagggcta tggattccca gcccatccct 5580 gtgaaggagt aggccactct ttaagtgaag gattggatga ttgttcataa tacataaagt 5640 tctctgtaat tacaactaaa ttattatgcc ctcttctcac agtcaaaagg aactgggtgg 5700 tttggttttt gttgcttttt tagatttatt gtcccatgtg ggatgagttt ttaaatgcca 5760 caagacataa tttaaaataa ataaactttg ggaaaaggtg taaaacagta gccccatcac 5820 atttgtgata ctgacaggta tcaacccaga agcccatgaa ctgtgtttcc atcctttgca 5880 tttctctgcg agtagttcca cacaggtttg taagtaagta agaaagaagg caaattgatt 5940 caaatgttac aaaaaaaccc ttcttggtgg attagacagg ttaaatatat aaacaaacaa 6000 acaaaaattg ctcaaaaaag aggagaaaag ctcaagagga aaagctaagg actggtagga 6060 aaaagcttta ctctttcatg ccattttatt tctttttgat ttttaaatca ttcattcaat 6120 agataccacc gtgtgaccta taattttgca aatctgttac ctctgacatc aagtgtaatt 6180 agcttttgga gagtgggctg acatcaagtg taattagctt ttggagagtg ggttttgtcc 6240 attattaata attaattaat taacatcaaa cacggcttct catgctattt ctacctcact 6300 ttggttttgg ggtgttcctg ataattgtgc acacctgagt tcacagcttc accacttgtc 6360 cattgcgtta ttttcttttt cctttataat tctttctttt tccttcataa ttttcaaaag 6420 aaaacccaaa gctctaaggt aacaaattac caaattacat gaagatttgg tttttgtctt 6480 gcattttttt cctttatgtg acgctggacc ttttctttac ccaaggattt ttaaaactca 6540 gatttaaaac aaggggttac tttacatcct actaagaagt ttaagtaagt aagtttcatt 6600 ctaaaatcag aggtaaatag agtgcataaa taattttgtt ttaatctttt tgtttttctt 6660 ttagacacat tagctctgga gtgagtctgt cataatattt gaacaaaaat tgagagcttt 6720 attgctgcat tttaagcata attaatttgg acattatttc gtgttgtgtt ctttataacc 6780 accaagtatt aaactgtaaa tcataatgta actgaagcat aaacatcaca tggcatgttt 6840 tgtcattgtt ttcaggtact gagttcttac ttgagtatca taatatattg tgttttaaca 6900 ccaacactgt aacatttacg aattattttt ttaaacttca gttttactgc attttcacaa 6960 catatcagac ttcaccaaat atatgcctta ctattgtatt atagtactgc tttactgtgt 7020 atctcaataa agcacgcagt tatgttac 7048 <210> 37 <211> 1133 <212> PRT <213> Homo sapiens <400> 37 Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn 1 5 10 15 Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val 20 25 30 Ile Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 35 40 45 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg Arg 50 55 60 Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn Lys 65 70 75 80 Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg 85 90 95 Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg 100 105 110 Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala 115 120 125 Lys Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu 130 135 140 Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile 145 150 155 160 Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn 165 170 175 Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr Ser 180 185 190 Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile Asn Ala 195 200 205 Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu 210 215 220 Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys 225 230 235 240 Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln 245 250 255 Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys 260 265 270 Glu Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 275 280 285 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg 290 295 300 Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp 305 310 315 320 Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile 325 330 335 Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu 340 345 350 Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu 355 360 365 Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln 370 375 380 Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro 385 390 395 400 Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln 405 410 415 Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro 420 425 430 Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala 435 440 445 Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp 450 455 460 Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln 465 470 475 480 Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile 485 490 495 Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln 500 505 510 Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 515 520 525 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr 530 535 540 Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu 545 550 555 560 Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg 565 570 575 Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe 580 585 590 Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn 595 600 605 Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp 610 615 620 His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 625 630 635 640 Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 645 650 655 Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 660 665 670 Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu 675 680 685 Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 690 695 700 His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn 705 710 715 720 Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val 725 730 735 Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu 740 745 750 Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 755 760 765 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 770 775 780 Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu 785 790 795 800 Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile 805 810 815 Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 820 825 830 Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys 835 840 845 His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 850 855 860 Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 865 870 875 880 Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 885 890 895 Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 900 905 910 Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys 915 920 925 His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 930 935 940 Asn Met Glu Thr Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln 945 950 955 960 His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met 965 970 975 Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala 980 985 990 Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile 995 1000 1005 Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu 1010 1015 1020 Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly 1025 1030 1035 Thr Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser 1040 1045 1050 Ser Gln Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp 1055 1060 1065 Ser Met Gly Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser 1070 1075 1080 Thr Gly Leu Glu Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro 1085 1090 1095 Ser Ser Arg Gly His Asn Val Gly Ser Leu Phe His Met Ala Asp 1100 1105 1110 Asp Leu Gly Arg Ala Met Glu Ser Leu Val Ser Val Met Thr Asp 1115 1120 1125 Glu Glu Gly Ala Glu 1130 <210> 38 <211> 13897 <212> DNA <213> Homo sapiens <400> 38 acctaaccta acttgaatca tgcgaaaggg gagctgttgg aattcaaata gactttctgg 60 ttcccagcag tcggcagtaa tagaatgctt tcaggaagat gacagaatca ggagaaagat 120 gctgttttgc actatcttga tttgttacag cagccaactt attggcatga tggagtgaca 180 ggaaaaacag ctggcatgga agatgaaaga gaagatgttc aaaagaaaac attcacaaaa 240 tgggtaaatg cacaattttc taagtttggg aagcagcata ttgagaacct cttcagtgac 300 ctacaggatg ggaggcgcct cctagacctc ctcgaaggcc tgacagggca aaaactgcca 360 aaagaaaaag gatccacaag agttcatgcc ctgaacaatg tcaacaaggc actgcgggtt 420 ttgcagaaca ataatgttga tttagtgaat attggaagta ctgacatcgt agatggaaat 480 cataaactga ctcttggttt gatttggaat ataatcctcc actggcaggt caaaaatgta 540 atgaaaaata tcatggctgg attgcaacaa accaacagtg aaaagattct cctgagctgg 600 gtccgacaat caactcgtaa ttatccacag gttaatgtaa tcaacttcac caccagctgg 660 tctgatggcc tggctttgaa tgctctcatc catagtcata ggccagacct atttgactgg 720 aatagtgtgg tttgccagca gtcagccaca caacgactgg aacatgcatt caacatcgcc 780 agatatcaat taggcataga gaaactactc gatcctgaag atgttgatac cacctatcca 840 gataagaagt ccatcttaat gtacatcaca tcactcttcc aagttttgcc tcaacaagtg 900 agcattgaag ccatccagga agtggaaatg ttgccaaggc cacctaaagt gactaaagaa 960 gaacattttc agttacatca tcaaatgcac tattctcaac agatcacggt cagtctagca 1020 cagggatatg agagaacttc ttcccctaag cctcgattca agagctatgc ctacacacag 1080 gctgcttatg tcaccacctc tgaccctaca cggagcccat ttccttcaca gcatttggaa 1140 gctcctgaag acaagtcatt tggcagttca ttgatggaga gtgaagtaaa cctggaccgt 1200 tatcaaacag ctttagaaga agtattatcg tggcttcttt ctgctgagga cacattgcaa 1260 gcacaaggag agatttctaa tgatgtggaa gtggtgaaag accagtttca tactcatgag 1320 gggtacatga tggatttgac agcccatcag ggccgggttg gtaatattct acaattggga 1380 agtaagctga ttggaacagg aaaattatca gaagatgaag aaactgaagt acaagagcag 1440 atgaatctcc taaattcaag atgggaatgc ctcagggtag ctagcatgga aaaacaaagc 1500 aatttacata gagttttaat ggatctccag aatcagaaac tgaaagagtt gaatgactgg 1560 ctaacaaaaa cagaagaaag aacaaggaaa atggaggaag agcctcttgg acctgatctt 1620 gaagacctaa aacgccaagt acaacaacat aaggtgcttc aagaagatct agaacaagaa 1680 caagtcaggg tcaattctct cactcacatg gtggtggtag ttgatgaatc tagtggagat 1740 cacgcaactg ctgctttgga agaacaactt aaggtattgg gagatcgatg ggcaaacatc 1800 tgtagatgga cagaagaccg ctgggttctt ttacaagaca tccttctcaa atggcaacgt 1860 cttactgaag aacagtgcct ttttagtgca tggctttcag aaaaagaaga tgcagtgaac 1920 aagattcaca caactggctt taaagatcaa aatgaaatgt tatcaagtct tcaaaaactg 1980 gccgttttaa aagcggatct agaaaagaaa aagcaatcca tgggcaaact gtattcactc 2040 aaacaagatc ttctttcaac actgaagaat aagtcagtga cccagaagac ggaagcatgg 2100 ctggataact ttgcccggtg ttgggataat ttagtccaaa aacttgaaaa gagtacagca 2160 cagatttcac aggctgtcac caccactcag ccatcactaa cacagacaac tgtaatggaa 2220 acagtaacta cggtgaccac aagggaacag atcctggtaa agcatgctca agaggaactt 2280 ccaccaccac ctccccaaaa gaagaggcag attactgtgg attctgaaat taggaaaagg 2340 ttggatgttg atataactga acttcacagc tggattactc gctcagaagc tgtgttgcag 2400 agtcctgaat ttgcaatctt tcggaaggaa ggcaacttct cagacttaaa agaaaaagtc 2460 aatgccatag agcgagaaaa agctgagaag ttcagaaaac tgcaagatgc cagcagatca 2520 gctcaggccc tggtggaaca gatggtgaat gagggtgtta atgcagatag catcaaacaa 2580 gcctcagaac aactgaacag ccggtggatc gaattctgcc agttgctaag tgagagactt 2640 aactggctgg agtatcagaa caacatcatc gctttctata atcagctaca acaattggag 2700 cagatgacaa ctactgctga aaactggttg aaaatccaac ccaccacccc atcagagcca 2760 acagcaatta aaagtcagtt aaaaatttgt aaggatgaag tcaaccggct atcagatctt 2820 caacctcaaa ttgaacgatt aaaaattcaa agcatagccc tgaaagagaa aggacaagga 2880 cccatgttcc tggatgcaga ctttgtggcc tttacaaatc attttaagca agtcttttct 2940 gatgtgcagg ccagagagaa agagctacag acaatttttg acactttgcc accaatgcgc 3000 tatcaggaga ccatgagtgc catcaggaca tgggtccagc agtcagaaac caaactctcc 3060 atacctcaac ttagtgtcac cgactatgaa atcatggagc agagactcgg ggaattgcag 3120 gctttacaaa gttctctgca agagcaacaa agtggcctat actatctcag caccactgtg 3180 aaagagatgt cgaagaaagc gccctctgaa attagccgga aatatcaatc agaatttgaa 3240 gaaattgagg gacgctggaa gaagctctcc tcccagctgg ttgagcattg tcaaaagcta 3300 gaggagcaaa tgaataaact ccgaaaaatt cagaatcaca tacaaaccct gaagaaatgg 3360 atggctgaag ttgatgtttt tctgaaggag gaatggcctg cccttgggga ttcagaaatt 3420 ctaaaaaagc agctgaaaca gtgcagactt ttagtcagtg atattcagac aattcagccc 3480 agtctaaaca gtgtcaatga aggtgggcag aagataaaga atgaagcaga gccagagttt 3540 gcttcgagac ttgagacaga actcaaagaa cttaacactc agtgggatca catgtgccaa 3600 caggtctatg ccagaaagga ggccttgaag ggaggtttgg agaaaactgt aagcctccag 3660 aaagatctat cagagatgca cgaatggatg acacaagctg aagaagagta tcttgagaga 3720 gattttgaat ataaaactcc agatgaatta cagaaagcag ttgaagagat gaagagagct 3780 aaagaagagg cccaacaaaa agaagcgaaa gtgaaactcc ttactgagtc tgtaaatagt 3840 gtcatagctc aagctccacc tgtagcacaa gaggccttaa aaaaggaact tgaaactcta 3900 accaccaact accagtggct ctgcactagg ctgaatggga aatgcaagac tttggaagaa 3960 gtttgggcat gttggcatga gttattgtca tacttggaga aagcaaacaa gtggctaaat 4020 gaagtagaat ttaaacttaa aaccactgaa aacattcctg gcggagctga ggaaatctct 4080 gaggtgctag attcacttga aaatttgatg cgacattcag aggataaccc aaatcagatt 4140 cgcatattgg cacagaccct aacagatggc ggagtcatgg atgagctaat caatgaggaa 4200 cttgagacat ttaattctcg ttggagggaa ctacatgaag aggctgtaag gaggcaaaag 4260 ttgcttgaac agagcatcca gtctgcccag gagactgaaa aatccttaca cttaatccag 4320 gagtccctca cattcattga caagcagttg gcagcttata ttgcagacaa ggtggacgca 4380 gctcaaatgc ctcaggaagc ccagaaaatc caatctgatt tgacaagtca tgagatcagt 4440 ttagaagaaa tgaagaaaca taatcagggg aaggaggctg cccaaagagt cctgtctcag 4500 attgatgttg cacagaaaaa attacaagat gtctccatga agtttcgatt attccagaaa 4560 ccagccaatt ttgagcagcg tctacaagaa agtaagatga ttttagatga agtgaagatg 4620 cacttgcctg cattggaaac aaagagtgtg gaacaggaag tagtacagtc acagctaaat 4680 cattgtgtga acttgtataa aagtctgagt gaagtgaagt ctgaagtgga aatggtgata 4740 aagactggac gtcagattgt acagaaaaag cagacggaaa atcccaaaga acttgatgaa 4800 agagtaacag ctttgaaatt gcattataat gagctgggag caaaggtaac agaaagaaag 4860 caacagttgg agaaatgctt gaaattgtcc cgtaagatgc gaaaggaaat gaatgtcttg 4920 acagaatggc tggcagctac agatatggaa ttgacaaaga gatcagcagt tgaaggaatg 4980 cctagtaatt tggattctga agttgcctgg ggaaaggcta ctcaaaaaga gattgagaaa 5040 cagaaggtgc acctgaagag tatcacagag gtaggagagg ccttgaaaac agttttgggc 5100 aagaaggaga cgttggtgga agataaactc agtcttctga atagtaactg gatagctgtc 5160 acctcccgag cagaagagtg gttaaatctt ttgttggaat accagaaaca catggaaact 5220 tttgaccaga atgtggacca catcacaaag tggatcattc aggctgacac acttttggat 5280 gaatcagaga aaaagaaacc ccagcaaaaa gaagacgtgc ttaagcgttt aaaggcagaa 5340 ctgaatgaca tacgcccaaa ggtggactct acacgtgacc aagcagcaaa cttgatggca 5400 aaccgcggtg accactgcag gaaattagta gagccccaaa tctcagagct caaccatcga 5460 tttgcagcca tttcacacag aattaagact ggaaaggcct ccattccttt gaaggaattg 5520 gagcagttta actcagatat acaaaaattg cttgaaccac tggaggctga aattcagcag 5580 ggggtgaatc tgaaagagga agacttcaat aaagatatga atgaagacaa tgagggtact 5640 gtaaaagaat tgttgcaaag aggagacaac ttacaacaaa gaatcacaga tgagagaaag 5700 cgagaggaaa taaagataaa acagcagctg ttacagacaa aacataatgc tctcaaggat 5760 ttgaggtctc aaagaagaaa aaaggctcta gaaatttctc atcagtggta tcagtacaag 5820 aggcaggctg atgatctcct gaaatgcttg gatgacattg aaaaaaaatt agccagccta 5880 cctgagccca gagatgaaag gaaaataaag gaaattgatc gggaattgca gaagaagaaa 5940 gaggagctga atgcagtgcg taggcaagct gagggcttgt ctgaggatgg ggccgcaatg 6000 gcagtggagc caactcagat ccagctcagc aagcgctggc gggaaattga gagcaaattt 6060 gctcagtttc gaagactcaa ctttgcacaa attcacactg tccgtgaaga aacgatgatg 6120 gtgatgactg aagacatgcc tttggaaatt tcttatgtgc cttctactta tttgactgaa 6180 atcactcatg tctcacaagc cctattagaa gtggaacaac ttctcaatgc tcctgacctc 6240 tgtgctaagg actttgaaga tctctttaag caagaggagt ctctgaagaa tataaaagat 6300 agtctacaac aaagctcagg tcggattgac attattcata gcaagaagac agcagcattg 6360 caaagtgcaa cgcctgtgga aagggtgaag ctacaggaag ctctctccca gcttgatttc 6420 caatgggaaa aagttaacaa aatgtacaag gaccgacaag ggcgatttga cagatctgtt 6480 gagaaatggc ggcgttttca ttatgatata aagatattta atcagtggct aacagaagct 6540 gaacagtttc tcagaaagac acaaattcct gagaattggg aacatgctaa atacaaatgg 6600 tatcttaagg aactccagga tggcattggg cagcggcaaa ctgttgtcag aacattgaat 6660 gcaactgggg aagaaataat tcagcaatcc tcaaaaacag atgccagtat tctacaggaa 6720 aaattgggaa gcctgaatct gcggtggcag gaggtctgca aacagctgtc agacagaaaa 6780 aagaggctag aagaacaaaa gaatatcttg tcagaatttc aaagagattt aaatgaattt 6840 gttttatggt tggaggaagc agataacatt gctagtatcc cacttgaacc tggaaaagag 6900 cagcaactaa aagaaaagct tgagcaagtc aagttactgg tggaagagtt gcccctgcgc 6960 cagggaattc tcaaacaatt aaatgaaact ggaggacccg tgcttgtaag tgctcccata 7020 agcccagaag agcaagataa acttgaaaat aagctcaagc agacaaatct ccagtggata 7080 aaggtttcca gagctttacc tgagaaacaa ggagaaattg aagctcaaat aaaagacctt 7140 gggcagcttg aaaaaaagct tgaagacctt gaagagcagt taaatcatct gctgctgtgg 7200 ttatctccta ttaggaatca gttggaaatt tataaccaac caaaccaaga aggaccattt 7260 gacgttaagg aaactgaaat agcagttcaa gctaaacaac cggatgtgga agagattttg 7320 tctaaagggc agcatttgta caaggaaaaa ccagccactc agccagtgaa gaggaagtta 7380 gaagatctga gctctgagtg gaaggcggta aaccgtttac ttcaagagct gagggcaaag 7440 cagcctgacc tagctcctgg actgaccact attggagcct ctcctactca gactgttact 7500 ctggtgacac aacctgtggt tactaaggaa actgccatct ccaaactaga aatgccatct 7560 tccttgatgt tggaggtacc tgctctggca gatttcaacc gggcttggac agaacttacc 7620 gactggcttt ctctgcttga tcaagttata aaatcacaga gggtgatggt gggtgacctt 7680 gaggatatca acgagatgat catcaagcag aaggcaacaa tgcaggattt ggaacagagg 7740 cgtccccagt tggaagaact cattaccgct gcccaaaatt tgaaaaacaa gaccagcaat 7800 caagaggcta gaacaatcat tacggatcga attgaaagaa ttcagaatca gtgggatgaa 7860 gtacaagaac accttcagaa ccggaggcaa cagttgaatg aaatgttaaa ggattcaaca 7920 caatggctgg aagctaagga agaagctgag caggtcttag gacaggccag agccaagctt 7980 gagtcatgga aggagggtcc ctatacagta gatgcaatcc aaaagaaaat cacagaaacc 8040 aagcagttgg ccaaagacct ccgccagtgg cagacaaatg tagatgtggc aaatgacttg 8100 gccctgaaac ttctccggga ttattctgca gatgatacca gaaaagtcca catgataaca 8160 gagaatatca atgcctcttg gagaagcatt cataaaaggg tgagtgagcg agaggctgct 8220 ttggaagaaa ctcatagatt actgcaacag ttccccctgg acctggaaaa gtttcttgcc 8280 tggcttacag aagctgaaac aactgccaat gtcctacagg atgctacccg taaggaaagg 8340 ctcctagaag actccaaggg agtaaaagag ctgatgaaac aatggcaaga cctccaaggt 8400 gaaattgaag ctcacacaga tgtttatcac aacctggatg aaaacagcca aaaaatcctg 8460 agatccctgg aaggttccga tgatgcagtc ctgttacaaa gacgtttgga taacatgaac 8520 ttcaagtgga gtgaacttcg gaaaaagtct ctcaacatta ggtcccattt ggaagccagt 8580 tctgaccagt ggaagcgtct gcacctttct ctgcaggaac ttctggtgtg gctacagctg 8640 aaagatgatg aattaagccg gcaggcacct attggaggcg actttccagc agttcagaag 8700 cagaacgatg tacatagggc cttcaagagg gaattgaaaa ctaaagaacc tgtaatcatg 8760 agtactcttg agactgtacg aatatttctg acagagcagc ctttggaagg actagagaaa 8820 ctctaccagg agcccagaga gctgcctcct gaggagagag cccagaatgt cactcggctt 8880 ctacgaaagc aggctgagga ggtcaatact gagtgggaaa aattgaacct gcactccgct 8940 gactggcaga gaaaaataga tgagaccctt gaaagactcc gggaacttca agaggccacg 9000 gatgagctgg acctcaagct gcgccaagct gaggtgatca agggatcctg gcagcccgtg 9060 ggcgatctcc tcattgactc tctccaagat cacctcgaga aagtcaaggc acttcgagga 9120 gaaattgcgc ctctgaaaga gaacgtgagc cacgtcaatg accttgctcg ccagcttacc 9180 actttgggca ttcagctctc accgtataac ctcagcactc tggaagacct gaacaccaga 9240 tggaagcttc tgcaggtggc cgtcgaggac cgagtcaggc agctgcatga agcccacagg 9300 gactttggtc cagcatctca gcactttctt tccacgtctg tccagggtcc ctgggagaga 9360 gccatctcgc caaacaaagt gccctactat atcaaccacg agactcaaac aacttgctgg 9420 gaccatccca aaatgacaga gctctaccag tctttagctg acctgaataa tgtcagattc 9480 tcagcttata ggactgccat gaaactccga agactgcaga aggccctttg cttggatctc 9540 ttgagcctgt cagctgcatg tgatgccttg gaccagcaca acctcaagca aaatgaccag 9600 cccatggata tcctgcagat tattaattgt ttgaccacta tttatgaccg cctggagcaa 9660 gagcacaaca atttggtcaa cgtccctctc tgcgtggata tgtgtctgaa ctggctgctg 9720 aatgtttatg atacgggacg aacagggagg atccgtgtcc tgtcttttaa aactggcatc 9780 atttccctgt gtaaagcaca tttggaagac aagtacagat accttttcaa gcaagtggca 9840 agttcaacag gattttgtga ccagcgcagg ctgggcctcc ttctgcatga ttctatccaa 9900 attccaagac agttgggtga agttgcatcc tttgggggca gtaacattga gccaagtgtc 9960 cggagctgct tccaatttgc taataataag ccagagatcg aagcggccct cttcctagac 10020 tggatgagac tggaacccca gtccatggtg tggctgcccg tcctgcacag agtggctgct 10080 gcagaaactg ccaagcatca ggccaaatgt aacatctgca aagagtgtcc aatcattgga 10140 ttcaggtaca ggagtctaaa gcactttaat tatgacatct gccaaagctg ctttttttct 10200 ggtcgagttg caaaaggcca taaaatgcac tatcccatgg tggaatattg cactccgact 10260 acatcaggag aagatgttcg agactttgcc aaggtactaa aaaacaaatt tcgaaccaaa 10320 aggtattttg cgaagcatcc ccgaatgggc tacctgccag tgcagactgt cttagagggg 10380 gacaacatgg aaactcccgt tactctgatc aacttctggc cagtagattc tgcgcctgcc 10440 tcgtcccctc agctttcaca cgatgatact cattcacgca ttgaacatta tgctagcagg 10500 ctagcagaaa tggaaaacag caatggatct tatctaaatg atagcatctc tcctaatgag 10560 agcatagatg atgaacattt gttaatccag cattactgcc aaagtttgaa ccaggactcc 10620 cccctgagcc agcctcgtag tcctgcccag atcttgattt ccttagagag tgaggaaaga 10680 ggggagctag agagaatcct agcagatctt gaggaagaaa acaggaatct gcaagcagaa 10740 tatgaccgtc taaagcagca gcacgaacat aaaggcctgt ccccactgcc gtcccctcct 10800 gaaatgatgc ccacctctcc ccagagtccc cgggatgctg agctcattgc tgaggccaag 10860 ctactgcgtc aacacaaagg ccgcctggaa gccaggatgc aaatcctgga agaccacaat 10920 aaacagctgg agtcacagtt acacaggcta aggcagctgc tggagcaacc ccaggcagag 10980 gccaaagtga atggcacaac ggtgtcctct ccttctacct ctctacagag gtccgacagc 11040 agtcagccta tgctgctccg agtggttggc agtcaaactt cggactccat gggtgaggaa 11100 gatcttctca gtcctcccca ggacacaagc acagggttag aggaggtgat ggagcaactc 11160 aacaactcct tccctagttc aagaggacac aatgtaggaa gtcttttcca catggcagat 11220 gatttgggca gagcgatgga gtccttagta tcagtcatga cagatgaaga aggagcagaa 11280 taaatgtttt acaactcctg attcccgcat ggtttttata atattcatac aacaaagagg 11340 attagacagt aagagtttac aagaaataaa tctatatttt tgtgaagggt agtggtatta 11400 tactgtagat ttcagtagtt tctaagtctg ttattgtttt gttaacaatg gcaggtttta 11460 cacgtctatg caattgtaca aaaaagttat aagaaaacta catgtaaaat cttgatagct 11520 aaataacttg ccatttcttt atatggaacg cattttgggt tgtttaaaaa tttataacag 11580 ttataaagaa agattgtaaa ctaaagtgtg ctttataaaa aaaagttgtt tataaaaacc 11640 cctaaaaaca aaacaaacac acacacacac acatacacac acacacacaa aactttgagg 11700 cagcgcattg ttttgcatcc ttttggcgtg atatccatat gaaattcatg gctttttctt 11760 tttttgcata ttaaagataa gacttcctct accaccacac caaatgacta ctacacactg 11820 ctcatttgag aactgtcagc tgagtggggc aggcttgagt tttcatttca tatatctata 11880 tgtctataag tatataaata ctatagttat atagataaag agatacgaat ttctatagac 11940 tgactttttc cattttttaa atgttcatgt cacatcctaa tagaaagaaa ttacttctag 12000 tcagtcatcc aggcttacct gcttggtcta gaatggattt ttcccggagc cggaagccag 12060 gaggaaacta caccacacta aaacattgtc tacagctcca gatgtttctc attttaaaca 12120 actttccact gacaacgaaa gtaaagtaaa gtattggatt tttttaaagg gaacatgtga 12180 atgaatacac aggacttatt atatcagagt gagtaatcgg ttggttggtt gattgattga 12240 ttgattgata cattcagctt cctgctgcta gcaatgccac gatttagatt taatgatgct 12300 tcagtggaaa tcaatcagaa ggtattctga ccttgtgaac atcagaaggt attttttaac 12360 tcccaagcag tagcaggacg atgatagggc tggagggcta tggattccca gcccatccct 12420 gtgaaggagt aggccactct ttaagtgaag gattggatga ttgttcataa tacataaagt 12480 tctctgtaat tacaactaaa ttattatgcc ctcttctcac agtcaaaagg aactgggtgg 12540 tttggttttt gttgcttttt tagatttatt gtcccatgtg ggatgagttt ttaaatgcca 12600 caagacataa tttaaaataa ataaactttg ggaaaaggtg taaaacagta gccccatcac 12660 atttgtgata ctgacaggta tcaacccaga agcccatgaa ctgtgtttcc atcctttgca 12720 tttctctgcg agtagttcca cacaggtttg taagtaagta agaaagaagg caaattgatt 12780 caaatgttac aaaaaaaccc ttcttggtgg attagacagg ttaaatatat aaacaaacaa 12840 acaaaaattg ctcaaaaaag aggagaaaag ctcaagagga aaagctaagg actggtagga 12900 aaaagcttta ctctttcatg ccattttatt tctttttgat ttttaaatca ttcattcaat 12960 agataccacc gtgtgaccta taattttgca aatctgttac ctctgacatc aagtgtaatt 13020 agcttttgga gagtgggctg acatcaagtg taattagctt ttggagagtg ggttttgtcc 13080 attattaata attaattaat taacatcaaa cacggcttct catgctattt ctacctcact 13140 ttggttttgg ggtgttcctg ataattgtgc acacctgagt tcacagcttc accacttgtc 13200 cattgcgtta ttttcttttt cctttataat tctttctttt tccttcataa ttttcaaaag 13260 aaaacccaaa gctctaaggt aacaaattac caaattacat gaagatttgg tttttgtctt 13320 gcattttttt cctttatgtg acgctggacc ttttctttac ccaaggattt ttaaaactca 13380 gatttaaaac aaggggttac tttacatcct actaagaagt ttaagtaagt aagtttcatt 13440 ctaaaatcag aggtaaatag agtgcataaa taattttgtt ttaatctttt tgtttttctt 13500 ttagacacat tagctctgga gtgagtctgt cataatattt gaacaaaaat tgagagcttt 13560 attgctgcat tttaagcata attaatttgg acattatttc gtgttgtgtt ctttataacc 13620 accaagtatt aaactgtaaa tcataatgta actgaagcat aaacatcaca tggcatgttt 13680 tgtcattgtt ttcaggtact gagttcttac ttgagtatca taatatattg tgttttaaca 13740 ccaacactgt aacatttacg aattattttt ttaaacttca gttttactgc attttcacaa 13800 catatcagac ttcaccaaat atatgcctta ctattgtatt atagtactgc tttactgtgt 13860 atctcaataa agcacgcagt tatgttacaa aaaagta 13897 <210> 39 <211> 3695 <212> PRT <213> Homo sapiens <400> 39 Met Glu Asp Glu Arg Glu Asp Val Gln Lys Lys Thr Phe Thr Lys Trp 1 5 10 15 Val Asn Ala Gln Phe Ser Lys Phe Gly Lys Gln His Ile Glu Asn Leu 20 25 30 Phe Ser Asp Leu Gln Asp Gly Arg Arg Leu Leu Asp Leu Leu Glu Gly 35 40 45 Leu Thr Gly Gln Lys Leu Pro Lys Glu Lys Gly Ser Thr Arg Val His 50 55 60 Ala Leu Asn Asn Val Asn Lys Ala Leu Arg Val Leu Gln Asn Asn Asn 65 70 75 80 Val Asp Leu Val Asn Ile Gly Ser Thr Asp Ile Val Asp Gly Asn His 85 90 95 Lys Leu Thr Leu Gly Leu Ile Trp Asn Ile Ile Leu His Trp Gln Val 100 105 110 Lys Asn Val Met Lys Asn Ile Met Ala Gly Leu Gln Gln Thr Asn Ser 115 120 125 Glu Lys Ile Leu Leu Ser Trp Val Arg Gln Ser Thr Arg Asn Tyr Pro 130 135 140 Gln Val Asn Val Ile Asn Phe Thr Thr Ser Trp Ser Asp Gly Leu Ala 145 150 155 160 Leu Asn Ala Leu Ile His Ser His Arg Pro Asp Leu Phe Asp Trp Asn 165 170 175 Ser Val Val Cys Gln Gln Ser Ala Thr Gln Arg Leu Glu His Ala Phe 180 185 190 Asn Ile Ala Arg Tyr Gln Leu Gly Ile Glu Lys Leu Leu Asp Pro Glu 195 200 205 Asp Val Asp Thr Thr Tyr Pro Asp Lys Lys Ser Ile Leu Met Tyr Ile 210 215 220 Thr Ser Leu Phe Gln Val Leu Pro Gln Gln Val Ser Ile Glu Ala Ile 225 230 235 240 Gln Glu Val Glu Met Leu Pro Arg Pro Pro Lys Val Thr Lys Glu Glu 245 250 255 His Phe Gln Leu His His Gln Met His Tyr Ser Gln Gln Ile Thr Val 260 265 270 Ser Leu Ala Gln Gly Tyr Glu Arg Thr Ser Ser Pro Lys Pro Arg Phe 275 280 285 Lys Ser Tyr Ala Tyr Thr Gln Ala Ala Tyr Val Thr Thr Ser Asp Pro 290 295 300 Thr Arg Ser Pro Phe Pro Ser Gln His Leu Glu Ala Pro Glu Asp Lys 305 310 315 320 Ser Phe Gly Ser Ser Leu Met Glu Ser Glu Val Asn Leu Asp Arg Tyr 325 330 335 Gln Thr Ala Leu Glu Glu Val Leu Ser Trp Leu Leu Ser Ala Glu Asp 340 345 350 Thr Leu Gln Ala Gln Gly Glu Ile Ser Asn Asp Val Glu Val Val Lys 355 360 365 Asp Gln Phe His Thr His Glu Gly Tyr Met Met Asp Leu Thr Ala His 370 375 380 Gln Gly Arg Val Gly Asn Ile Leu Gln Leu Gly Ser Lys Leu Ile Gly 385 390 395 400 Thr Gly Lys Leu Ser Glu Asp Glu Glu Thr Glu Val Gln Glu Gln Met 405 410 415 Asn Leu Leu Asn Ser Arg Trp Glu Cys Leu Arg Val Ala Ser Met Glu 420 425 430 Lys Gln Ser Asn Leu His Arg Val Leu Met Asp Leu Gln Asn Gln Lys 435 440 445 Leu Lys Glu Leu Asn Asp Trp Leu Thr Lys Thr Glu Glu Arg Thr Arg 450 455 460 Lys Met Glu Glu Glu Pro Leu Gly Pro Asp Leu Glu Asp Leu Lys Arg 465 470 475 480 Gln Val Gln Gln His Lys Val Leu Gln Glu Asp Leu Glu Gln Glu Gln 485 490 495 Val Arg Val Asn Ser Leu Thr His Met Val Val Val Val Asp Glu Ser 500 505 510 Ser Gly Asp His Ala Thr Ala Ala Leu Glu Glu Gln Leu Lys Val Leu 515 520 525 Gly Asp Arg Trp Ala Asn Ile Cys Arg Trp Thr Glu Asp Arg Trp Val 530 535 540 Leu Leu Gln Asp Ile Leu Leu Lys Trp Gln Arg Leu Thr Glu Glu Gln 545 550 555 560 Cys Leu Phe Ser Ala Trp Leu Ser Glu Lys Glu Asp Ala Val Asn Lys 565 570 575 Ile His Thr Thr Gly Phe Lys Asp Gln Asn Glu Met Leu Ser Ser Leu 580 585 590 Gln Lys Leu Ala Val Leu Lys Ala Asp Leu Glu Lys Lys Lys Gln Ser 595 600 605 Met Gly Lys Leu Tyr Ser Leu Lys Gln Asp Leu Leu Ser Thr Leu Lys 610 615 620 Asn Lys Ser Val Thr Gln Lys Thr Glu Ala Trp Leu Asp Asn Phe Ala 625 630 635 640 Arg Cys Trp Asp Asn Leu Val Gln Lys Leu Glu Lys Ser Thr Ala Gln 645 650 655 Ile Ser Gln Ala Val Thr Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr 660 665 670 Val Met Glu Thr Val Thr Thr Val Thr Thr Arg Glu Gln Ile Leu Val 675 680 685 Lys His Ala Gln Glu Glu Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg 690 695 700 Gln Ile Thr Val Asp Ser Glu Ile Arg Lys Arg Leu Asp Val Asp Ile 705 710 715 720 Thr Glu Leu His Ser Trp Ile Thr Arg Ser Glu Ala Val Leu Gln Ser 725 730 735 Pro Glu Phe Ala Ile Phe Arg Lys Glu Gly Asn Phe Ser Asp Leu Lys 740 745 750 Glu Lys Val Asn Ala Ile Glu Arg Glu Lys Ala Glu Lys Phe Arg Lys 755 760 765 Leu Gln Asp Ala Ser Arg Ser Ala Gln Ala Leu Val Glu Gln Met Val 770 775 780 Asn Glu Gly Val Asn Ala Asp Ser Ile Lys Gln Ala Ser Glu Gln Leu 785 790 795 800 Asn Ser Arg Trp Ile Glu Phe Cys Gln Leu Leu Ser Glu Arg Leu Asn 805 810 815 Trp Leu Glu Tyr Gln Asn Asn Ile Ile Ala Phe Tyr Asn Gln Leu Gln 820 825 830 Gln Leu Glu Gln Met Thr Thr Thr Ala Glu Asn Trp Leu Lys Ile Gln 835 840 845 Pro Thr Thr Pro Ser Glu Pro Thr Ala Ile Lys Ser Gln Leu Lys Ile 850 855 860 Cys Lys Asp Glu Val Asn Arg Leu Ser Asp Leu Gln Pro Gln Ile Glu 865 870 875 880 Arg Leu Lys Ile Gln Ser Ile Ala Leu Lys Glu Lys Gly Gln Gly Pro 885 890 895 Met Phe Leu Asp Ala Asp Phe Val Ala Phe Thr Asn His Phe Lys Gln 900 905 910 Val Phe Ser Asp Val Gln Ala Arg Glu Lys Glu Leu Gln Thr Ile Phe 915 920 925 Asp Thr Leu Pro Pro Met Arg Tyr Gln Glu Thr Met Ser Ala Ile Arg 930 935 940 Thr Trp Val Gln Gln Ser Glu Thr Lys Leu Ser Ile Pro Gln Leu Ser 945 950 955 960 Val Thr Asp Tyr Glu Ile Met Glu Gln Arg Leu Gly Glu Leu Gln Ala 965 970 975 Leu Gln Ser Ser Leu Gln Glu Gln Gln Ser Gly Leu Tyr Tyr Leu Ser 980 985 990 Thr Thr Val Lys Glu Met Ser Lys Lys Ala Pro Ser Glu Ile Ser Arg 995 1000 1005 Lys Tyr Gln Ser Glu Phe Glu Glu Ile Glu Gly Arg Trp Lys Lys 1010 1015 1020 Leu Ser Ser Gln Leu Val Glu His Cys Gln Lys Leu Glu Glu Gln 1025 1030 1035 Met Asn Lys Leu Arg Lys Ile Gln Asn His Ile Gln Thr Leu Lys 1040 1045 1050 Lys Trp Met Ala Glu Val Asp Val Phe Leu Lys Glu Glu Trp Pro 1055 1060 1065 Ala Leu Gly Asp Ser Glu Ile Leu Lys Lys Gln Leu Lys Gln Cys 1070 1075 1080 Arg Leu Leu Val Ser Asp Ile Gln Thr Ile Gln Pro Ser Leu Asn 1085 1090 1095 Ser Val Asn Glu Gly Gly Gln Lys Ile Lys Asn Glu Ala Glu Pro 1100 1105 1110 Glu Phe Ala Ser Arg Leu Glu Thr Glu Leu Lys Glu Leu Asn Thr 1115 1120 1125 Gln Trp Asp His Met Cys Gln Gln Val Tyr Ala Arg Lys Glu Ala 1130 1135 1140 Leu Lys Gly Gly Leu Glu Lys Thr Val Ser Leu Gln Lys Asp Leu 1145 1150 1155 Ser Glu Met His Glu Trp Met Thr Gln Ala Glu Glu Glu Tyr Leu 1160 1165 1170 Glu Arg Asp Phe Glu Tyr Lys Thr Pro Asp Glu Leu Gln Lys Ala 1175 1180 1185 Val Glu Glu Met Lys Arg Ala Lys Glu Glu Ala Gln Gln Lys Glu 1190 1195 1200 Ala Lys Val Lys Leu Leu Thr Glu Ser Val Asn Ser Val Ile Ala 1205 1210 1215 Gln Ala Pro Pro Val Ala Gln Glu Ala Leu Lys Lys Glu Leu Glu 1220 1225 1230 Thr Leu Thr Thr Asn Tyr Gln Trp Leu Cys Thr Arg Leu Asn Gly 1235 1240 1245 Lys Cys Lys Thr Leu Glu Glu Val Trp Ala Cys Trp His Glu Leu 1250 1255 1260 Leu Ser Tyr Leu Glu Lys Ala Asn Lys Trp Leu Asn Glu Val Glu 1265 1270 1275 Phe Lys Leu Lys Thr Thr Glu Asn Ile Pro Gly Gly Ala Glu Glu 1280 1285 1290 Ile Ser Glu Val Leu Asp Ser Leu Glu Asn Leu Met Arg His Ser 1295 1300 1305 Glu Asp Asn Pro Asn Gln Ile Arg Ile Leu Ala Gln Thr Leu Thr 1310 1315 1320 Asp Gly Gly Val Met Asp Glu Leu Ile Asn Glu Glu Leu Glu Thr 1325 1330 1335 Phe Asn Ser Arg Trp Arg Glu Leu His Glu Glu Ala Val Arg Arg 1340 1345 1350 Gln Lys Leu Leu Glu Gln Ser Ile Gln Ser Ala Gln Glu Thr Glu 1355 1360 1365 Lys Ser Leu His Leu Ile Gln Glu Ser Leu Thr Phe Ile Asp Lys 1370 1375 1380 Gln Leu Ala Ala Tyr Ile Ala Asp Lys Val Asp Ala Ala Gln Met 1385 1390 1395 Pro Gln Glu Ala Gln Lys Ile Gln Ser Asp Leu Thr Ser His Glu 1400 1405 1410 Ile Ser Leu Glu Glu Met Lys Lys His Asn Gln Gly Lys Glu Ala 1415 1420 1425 Ala Gln Arg Val Leu Ser Gln Ile Asp Val Ala Gln Lys Lys Leu 1430 1435 1440 Gln Asp Val Ser Met Lys Phe Arg Leu Phe Gln Lys Pro Ala Asn 1445 1450 1455 Phe Glu Gln Arg Leu Gln Glu Ser Lys Met Ile Leu Asp Glu Val 1460 1465 1470 Lys Met His Leu Pro Ala Leu Glu Thr Lys Ser Val Glu Gln Glu 1475 1480 1485 Val Val Gln Ser Gln Leu Asn His Cys Val Asn Leu Tyr Lys Ser 1490 1495 1500 Leu Ser Glu Val Lys Ser Glu Val Glu Met Val Ile Lys Thr Gly 1505 1510 1515 Arg Gln Ile Val Gln Lys Lys Gln Thr Glu Asn Pro Lys Glu Leu 1520 1525 1530 Asp Glu Arg Val Thr Ala Leu Lys Leu His Tyr Asn Glu Leu Gly 1535 1540 1545 Ala Lys Val Thr Glu Arg Lys Gln Gln Leu Glu Lys Cys Leu Lys 1550 1555 1560 Leu Ser Arg Lys Met Arg Lys Glu Met Asn Val Leu Thr Glu Trp 1565 1570 1575 Leu Ala Ala Thr Asp Met Glu Leu Thr Lys Arg Ser Ala Val Glu 1580 1585 1590 Gly Met Pro Ser Asn Leu Asp Ser Glu Val Ala Trp Gly Lys Ala 1595 1600 1605 Thr Gln Lys Glu Ile Glu Lys Gln Lys Val His Leu Lys Ser Ile 1610 1615 1620 Thr Glu Val Gly Glu Ala Leu Lys Thr Val Leu Gly Lys Lys Glu 1625 1630 1635 Thr Leu Val Glu Asp Lys Leu Ser Leu Leu Asn Ser Asn Trp Ile 1640 1645 1650 Ala Val Thr Ser Arg Ala Glu Glu Trp Leu Asn Leu Leu Leu Glu 1655 1660 1665 Tyr Gln Lys His Met Glu Thr Phe Asp Gln Asn Val Asp His Ile 1670 1675 1680 Thr Lys Trp Ile Ile Gln Ala Asp Thr Leu Leu Asp Glu Ser Glu 1685 1690 1695 Lys Lys Lys Pro Gln Gln Lys Glu Asp Val Leu Lys Arg Leu Lys 1700 1705 1710 Ala Glu Leu Asn Asp Ile Arg Pro Lys Val Asp Ser Thr Arg Asp 1715 1720 1725 Gln Ala Ala Asn Leu Met Ala Asn Arg Gly Asp His Cys Arg Lys 1730 1735 1740 Leu Val Glu Pro Gln Ile Ser Glu Leu Asn His Arg Phe Ala Ala 1745 1750 1755 Ile Ser His Arg Ile Lys Thr Gly Lys Ala Ser Ile Pro Leu Lys 1760 1765 1770 Glu Leu Glu Gln Phe Asn Ser Asp Ile Gln Lys Leu Leu Glu Pro 1775 1780 1785 Leu Glu Ala Glu Ile Gln Gln Gly Val Asn Leu Lys Glu Glu Asp 1790 1795 1800 Phe Asn Lys Asp Met Asn Glu Asp Asn Glu Gly Thr Val Lys Glu 1805 1810 1815 Leu Leu Gln Arg Gly Asp Asn Leu Gln Gln Arg Ile Thr Asp Glu 1820 1825 1830 Arg Lys Arg Glu Glu Ile Lys Ile Lys Gln Gln Leu Leu Gln Thr 1835 1840 1845 Lys His Asn Ala Leu Lys Asp Leu Arg Ser Gln Arg Arg Lys Lys 1850 1855 1860 Ala Leu Glu Ile Ser His Gln Trp Tyr Gln Tyr Lys Arg Gln Ala 1865 1870 1875 Asp Asp Leu Leu Lys Cys Leu Asp Asp Ile Glu Lys Lys Leu Ala 1880 1885 1890 Ser Leu Pro Glu Pro Arg Asp Glu Arg Lys Ile Lys Glu Ile Asp 1895 1900 1905 Arg Glu Leu Gln Lys Lys Lys Glu Glu Leu Asn Ala Val Arg Arg 1910 1915 1920 Gln Ala Glu Gly Leu Ser Glu Asp Gly Ala Ala Met Ala Val Glu 1925 1930 1935 Pro Thr Gln Ile Gln Leu Ser Lys Arg Trp Arg Glu Ile Glu Ser 1940 1945 1950 Lys Phe Ala Gln Phe Arg Arg Leu Asn Phe Ala Gln Ile His Thr 1955 1960 1965 Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu 1970 1975 1980 Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His 1985 1990 1995 Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro 2000 2005 2010 Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu 2015 2020 2025 Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg 2030 2035 2040 Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala 2045 2050 2055 Thr Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu 2060 2065 2070 Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln 2075 2080 2085 Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr 2090 2095 2100 Asp Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe 2105 2110 2115 Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys Tyr 2120 2125 2130 Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln 2135 2140 2145 Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln 2150 2155 2160 Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly 2165 2170 2175 Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser Asp 2180 2185 2190 Arg Lys Lys Arg Leu Glu Glu Gln Lys Asn Ile Leu Ser Glu Phe 2195 2200 2205 Gln Arg Asp Leu Asn Glu Phe Val Leu Trp Leu Glu Glu Ala Asp 2210 2215 2220 Asn Ile Ala Ser Ile Pro Leu Glu Pro Gly Lys Glu Gln Gln Leu 2225 2230 2235 Lys Glu Lys Leu Glu Gln Val Lys Leu Leu Val Glu Glu Leu Pro 2240 2245 2250 Leu Arg Gln Gly Ile Leu Lys Gln Leu Asn Glu Thr Gly Gly Pro 2255 2260 2265 Val Leu Val Ser Ala Pro Ile Ser Pro Glu Glu Gln Asp Lys Leu 2270 2275 2280 Glu Asn Lys Leu Lys Gln Thr Asn Leu Gln Trp Ile Lys Val Ser 2285 2290 2295 Arg Ala Leu Pro Glu Lys Gln Gly Glu Ile Glu Ala Gln Ile Lys 2300 2305 2310 Asp Leu Gly Gln Leu Glu Lys Lys Leu Glu Asp Leu Glu Glu Gln 2315 2320 2325 Leu Asn His Leu Leu Leu Trp Leu Ser Pro Ile Arg Asn Gln Leu 2330 2335 2340 Glu Ile Tyr Asn Gln Pro Asn Gln Glu Gly Pro Phe Asp Val Lys 2345 2350 2355 Glu Thr Glu Ile Ala Val Gln Ala Lys Gln Pro Asp Val Glu Glu 2360 2365 2370 Ile Leu Ser Lys Gly Gln His Leu Tyr Lys Glu Lys Pro Ala Thr 2375 2380 2385 Gln Pro Val Lys Arg Lys Leu Glu Asp Leu Ser Ser Glu Trp Lys 2390 2395 2400 Ala Val Asn Arg Leu Leu Gln Glu Leu Arg Ala Lys Gln Pro Asp 2405 2410 2415 Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr 2420 2425 2430 Val Thr Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile 2435 2440 2445 Ser Lys Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala 2450 2455 2460 Leu Ala Asp Phe Asn Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu 2465 2470 2475 Ser Leu Leu Asp Gln Val Ile Lys Ser Gln Arg Val Met Val Gly 2480 2485 2490 Asp Leu Glu Asp Ile Asn Glu Met Ile Ile Lys Gln Lys Ala Thr 2495 2500 2505 Met Gln Asp Leu Glu Gln Arg Arg Pro Gln Leu Glu Glu Leu Ile 2510 2515 2520 Thr Ala Ala Gln Asn Leu Lys Asn Lys Thr Ser Asn Gln Glu Ala 2525 2530 2535 Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg Ile Gln Asn Gln Trp 2540 2545 2550 Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg Gln Gln Leu Asn 2555 2560 2565 Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala Lys Glu Glu 2570 2575 2580 Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu Ser Trp 2585 2590 2595 Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile Thr 2600 2605 2610 Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn 2615 2620 2625 Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr 2630 2635 2640 Ser Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile 2645 2650 2655 Asn Ala Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu 2660 2665 2670 Ala Ala Leu Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu 2675 2680 2685 Asp Leu Glu Lys Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr 2690 2695 2700 Ala Asn Val Leu Gln Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu 2705 2710 2715 Asp Ser Lys Gly Val Lys Glu Leu Met Lys Gln Trp Gln Asp Leu 2720 2725 2730 Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr His Asn Leu Asp 2735 2740 2745 Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp 2750 2755 2760 Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn Phe Lys Trp 2765 2770 2775 Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His Leu Glu 2780 2785 2790 Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu 2795 2800 2805 Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln 2810 2815 2820 Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp 2825 2830 2835 Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro Val 2840 2845 2850 Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln 2855 2860 2865 Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu 2870 2875 2880 Pro Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys 2885 2890 2895 Gln Ala Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His 2900 2905 2910 Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu 2915 2920 2925 Arg Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg 2930 2935 2940 Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu 2945 2950 2955 Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu 2960 2965 2970 Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn 2975 2980 2985 Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro 2990 2995 3000 Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu 3005 3010 3015 Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala 3020 3025 3030 His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser 3035 3040 3045 Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro 3050 3055 3060 Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro 3065 3070 3075 Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val 3080 3085 3090 Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 3095 3100 3105 Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp 3110 3115 3120 Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp 3125 3130 3135 Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu 3140 3145 3150 Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp 3155 3160 3165 Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr 3170 3175 3180 Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu 3185 3190 3195 Cys Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln 3200 3205 3210 Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu 3215 3220 3225 Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val 3230 3235 3240 Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys 3245 3250 3255 Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu Phe 3260 3265 3270 Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met Val Trp Leu Pro 3275 3280 3285 Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala 3290 3295 3300 Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe Arg Tyr 3305 3310 3315 Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys Phe 3320 3325 3330 Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 3335 3340 3345 Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp 3350 3355 3360 Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe 3365 3370 3375 Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu 3380 3385 3390 Glu Gly Asp Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp 3395 3400 3405 Pro Val Asp Ser Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp 3410 3415 3420 Asp Thr His Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu 3425 3430 3435 Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro 3440 3445 3450 Asn Glu Ser Ile Asp Asp Glu His Leu Leu Ile Gln His Tyr Cys 3455 3460 3465 Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro 3470 3475 3480 Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu Arg Gly Glu Leu 3485 3490 3495 Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn Leu Gln 3500 3505 3510 Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys Gly Leu 3515 3520 3525 Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro Gln 3530 3535 3540 Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg 3545 3550 3555 Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu Asp 3560 3565 3570 His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu 3575 3580 3585 Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val 3590 3595 3600 Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro 3605 3610 3615 Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly 3620 3625 3630 Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu 3635 3640 3645 Glu Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg 3650 3655 3660 Gly His Asn Val Gly Ser Leu Phe His Met Ala Asp Asp Leu Gly 3665 3670 3675 Arg Ala Met Glu Ser Leu Val Ser Val Met Thr Asp Glu Glu Gly 3680 3685 3690 Ala Glu 3695 <210> 40 <211> 13800 <212> DNA <213> Homo sapiens <400> 40 actttccccc tacaggactc agatctggga ggcaattacc ttcggagaaa aacgaatagg 60 aaaaactgaa gtgttacttt ttttaaagct gctgaagttt gttggtttct cattgttttt 120 aagcctactg gagcaataaa gtttgaagaa cttttaccag gtttttttta tcgctgcctt 180 gatatacact tttcaaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag 240 atgttcaaaa gaaaacattc acaaaatggg taaatgcaca attttctaag tttgggaagc 300 agcatattga gaacctcttc agtgacctac aggatgggag gcgcctccta gacctcctcg 360 aaggcctgac agggcaaaaa ctgccaaaag aaaaaggatc cacaagagtt catgccctga 420 acaatgtcaa caaggcactg cgggttttgc agaacaataa tgttgattta gtgaatattg 480 gaagtactga catcgtagat ggaaatcata aactgactct tggtttgatt tggaatataa 540 tcctccactg gcaggtcaaa aatgtaatga aaaatatcat ggctggattg caacaaacca 600 acagtgaaaa gattctcctg agctgggtcc gacaatcaac tcgtaattat ccacaggtta 660 atgtaatcaa cttcaccacc agctggtctg atggcctggc tttgaatgct ctcatccata 720 gtcataggcc agacctattt gactggaata gtgtggtttg ccagcagtca gccacacaac 780 gactggaaca tgcattcaac atcgccagat atcaattagg catagagaaa ctactcgatc 840 ctgaagatgt tgataccacc tatccagata agaagtccat cttaatgtac atcacatcac 900 tcttccaagt tttgcctcaa caagtgagca ttgaagccat ccaggaagtg gaaatgttgc 960 caaggccacc taaagtgact aaagaagaac attttcagtt acatcatcaa atgcactatt 1020 ctcaacagat cacggtcagt ctagcacagg gatatgagag aacttcttcc cctaagcctc 1080 gattcaagag ctatgcctac acacaggctg cttatgtcac cacctctgac cctacacgga 1140 gcccatttcc ttcacagcat ttggaagctc ctgaagacaa gtcatttggc agttcattga 1200 tggagagtga agtaaacctg gaccgttatc aaacagcttt agaagaagta ttatcgtggc 1260 ttctttctgc tgaggacaca ttgcaagcac aaggagagat ttctaatgat gtggaagtgg 1320 tgaaagacca gtttcatact catgaggggt acatgatgga tttgacagcc catcagggcc 1380 gggttggtaa tattctacaa ttgggaagta agctgattgg aacaggaaaa ttatcagaag 1440 atgaagaaac tgaagtacaa gagcagatga atctcctaaa ttcaagatgg gaatgcctca 1500 gggtagctag catggaaaaa caaagcaatt tacatagagt tttaatggat ctccagaatc 1560 agaaactgaa agagttgaat gactggctaa caaaaacaga agaaagaaca aggaaaatgg 1620 aggaagagcc tcttggacct gatcttgaag acctaaaacg ccaagtacaa caacataagg 1680 tgcttcaaga agatctagaa caagaacaag tcagggtcaa ttctctcact cacatggtgg 1740 tggtagttga tgaatctagt ggagatcacg caactgctgc tttggaagaa caacttaagg 1800 tattgggaga tcgatgggca aacatctgta gatggacaga agaccgctgg gttcttttac 1860 aagacatcct tctcaaatgg caacgtctta ctgaagaaca gtgccttttt agtgcatggc 1920 tttcagaaaa agaagatgca gtgaacaaga ttcacacaac tggctttaaa gatcaaaatg 1980 aaatgttatc aagtcttcaa aaactggccg ttttaaaagc ggatctagaa aagaaaaagc 2040 aatccatggg caaactgtat tcactcaaac aagatcttct ttcaacactg aagaataagt 2100 cagtgaccca gaagacggaa gcatggctgg ataactttgc ccggtgttgg gataatttag 2160 tccaaaaact tgaaaagagt acagcacaga tttcacaggc tgtcaccacc actcagccat 2220 cactaacaca gacaactgta atggaaacag taactacggt gaccacaagg gaacagatcc 2280 tggtaaagca tgctcaagag gaacttccac caccacctcc ccaaaagaag aggcagatta 2340 ctgtggattc tgaaattagg aaaaggttgg atgttgatat aactgaactt cacagctgga 2400 ttactcgctc agaagctgtg ttgcagagtc ctgaatttgc aatctttcgg aaggaaggca 2460 acttctcaga cttaaaagaa aaagtcaatg ccatagagcg agaaaaagct gagaagttca 2520 gaaaactgca agatgccagc agatcagctc aggccctggt ggaacagatg gtgaatgagg 2580 gtgttaatgc agatagcatc aaacaagcct cagaacaact gaacagccgg tggatcgaat 2640 tctgccagtt gctaagtgag agacttaact ggctggagta tcagaacaac atcatcgctt 2700 tctataatca gctacaacaa ttggagcaga tgacaactac tgctgaaaac tggttgaaaa 2760 tccaacccac caccccatca gagccaacag caattaaaag tcagttaaaa atttgtaagg 2820 atgaagtcaa ccggctatca gatcttcaac ctcaaattga acgattaaaa attcaaagca 2880 tagccctgaa agagaaagga caaggaccca tgttcctgga tgcagacttt gtggccttta 2940 caaatcattt taagcaagtc ttttctgatg tgcaggccag agagaaagag ctacagacaa 3000 tttttgacac tttgccacca atgcgctatc aggagaccat gagtgccatc aggacatggg 3060 tccagcagtc agaaaccaaa ctctccatac ctcaacttag tgtcaccgac tatgaaatca 3120 tggagcagag actcggggaa ttgcaggctt tacaaagttc tctgcaagag caacaaagtg 3180 gcctatacta tctcagcacc actgtgaaag agatgtcgaa gaaagcgccc tctgaaatta 3240 gccggaaata tcaatcagaa tttgaagaaa ttgagggacg ctggaagaag ctctcctccc 3300 agctggttga gcattgtcaa aagctagagg agcaaatgaa taaactccga aaaattcaga 3360 atcacataca aaccctgaag aaatggatgg ctgaagttga tgtttttctg aaggaggaat 3420 ggcctgccct tggggattca gaaattctaa aaaagcagct gaaacagtgc agacttttag 3480 tcagtgatat tcagacaatt cagcccagtc taaacagtgt caatgaaggt gggcagaaga 3540 taaagaatga agcagagcca gagtttgctt cgagacttga gacagaactc aaagaactta 3600 acactcagtg ggatcacatg tgccaacagg tctatgccag aaaggaggcc ttgaagggag 3660 gtttggagaa aactgtaagc ctccagaaag atctatcaga gatgcacgaa tggatgacac 3720 aagctgaaga agagtatctt gagagagatt ttgaatataa aactccagat gaattacaga 3780 aagcagttga agagatgaag agagctaaag aagaggccca acaaaaagaa gcgaaagtga 3840 aactccttac tgagtctgta aatagtgtca tagctcaagc tccacctgta gcacaagagg 3900 ccttaaaaaa ggaacttgaa actctaacca ccaactacca gtggctctgc actaggctga 3960 atgggaaatg caagactttg gaagaagttt gggcatgttg gcatgagtta ttgtcatact 4020 tggagaaagc aaacaagtgg ctaaatgaag tagaatttaa acttaaaacc actgaaaaca 4080 ttcctggcgg agctgaggaa atctctgagg tgctagattc acttgaaaat ttgatgcgac 4140 attcagagga taacccaaat cagattcgca tattggcaca gaccctaaca gatggcggag 4200 tcatggatga gctaatcaat gaggaacttg agacatttaa ttctcgttgg agggaactac 4260 atgaagaggc tgtaaggagg caaaagttgc ttgaacagag catccagtct gcccaggaga 4320 ctgaaaaatc cttacactta atccaggagt ccctcacatt cattgacaag cagttggcag 4380 cttatattgc agacaaggtg gacgcagctc aaatgcctca ggaagcccag aaaatccaat 4440 ctgatttgac aagtcatgag atcagtttag aagaaatgaa gaaacataat caggggaagg 4500 aggctgccca aagagtcctg tctcagattg atgttgcaca gaaaaaatta caagatgtct 4560 ccatgaagtt tcgattattc cagaaaccag ccaattttga gcagcgtcta caagaaagta 4620 agatgatttt agatgaagtg aagatgcact tgcctgcatt ggaaacaaag agtgtggaac 4680 aggaagtagt acagtcacag ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag 4740 tgaagtctga agtggaaatg gtgataaaga ctggacgtca gattgtacag aaaaagcaga 4800 cggaaaatcc caaagaactt gatgaaagag taacagcttt gaaattgcat tataatgagc 4860 tgggagcaaa ggtaacagaa agaaagcaac agttggagaa atgcttgaaa ttgtcccgta 4920 agatgcgaaa ggaaatgaat gtcttgacag aatggctggc agctacagat atggaattga 4980 caaagagatc agcagttgaa ggaatgccta gtaatttgga ttctgaagtt gcctggggaa 5040 aggctactca aaaagagatt gagaaacaga aggtgcacct gaagagtatc acagaggtag 5100 gagaggcctt gaaaacagtt ttgggcaaga aggagacgtt ggtggaagat aaactcagtc 5160 ttctgaatag taactggata gctgtcacct cccgagcaga agagtggtta aatcttttgt 5220 tggaatacca gaaacacatg gaaacttttg accagaatgt ggaccacatc acaaagtgga 5280 tcattcaggc tgacacactt ttggatgaat cagagaaaaa gaaaccccag caaaaagaag 5340 acgtgcttaa gcgtttaaag gcagaactga atgacatacg cccaaaggtg gactctacac 5400 gtgaccaagc agcaaacttg atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc 5460 cccaaatctc agagctcaac catcgatttg cagccatttc acacagaatt aagactggaa 5520 agaatgaaga caatgagggt actgtaaaag aattgttgca aagaggagac aacttacaac 5580 aaagaatcac agatgagaga aagcgagagg aaataaagat aaaacagcag ctgttacaga 5640 caaaacataa tgctctcaag gatttgaggt ctcaaagaag aaaaaaggct ctagaaattt 5700 ctcatcagtg gtatcagtac aagaggcagg ctgatgatct cctgaaatgc ttggatgaca 5760 ttgaaaaaaa attagccagc ctacctgagc ccagagatga aaggaaaata aaggaaattg 5820 atcgggaatt gcagaagaag aaagaggagc tgaatgcagt gcgtaggcaa gctgagggct 5880 tgtctgagga tggggccgca atggcagtgg agccaactca gatccagctc agcaagcgct 5940 ggcgggaaat tgagagcaaa tttgctcagt ttcgaagact caactttgca caaattcaca 6000 ctgtccgtga agaaacgatg atggtgatga ctgaagacat gcctttggaa atttcttatg 6060 tgccttctac ttatttgact gaaatcactc atgtctcaca agccctatta gaagtggaac 6120 aacttctcaa tgctcctgac ctctgtgcta aggactttga agatctcttt aagcaagagg 6180 agtctctgaa gaatataaaa gatagtctac aacaaagctc aggtcggatt gacattattc 6240 atagcaagaa gacagcagca ttgcaaagtg caacgcctgt ggaaagggtg aagctacagg 6300 aagctctctc ccagcttgat ttccaatggg aaaaagttaa caaaatgtac aaggaccgac 6360 aagggcgatt tgacagatct gttgagaaat ggcggcgttt tcattatgat ataaagatat 6420 ttaatcagtg gctaacagaa gctgaacagt ttctcagaaa gacacaaatt cctgagaatt 6480 gggaacatgc taaatacaaa tggtatctta aggaactcca ggatggcatt gggcagcggc 6540 aaactgttgt cagaacattg aatgcaactg gggaagaaat aattcagcaa tcctcaaaaa 6600 cagatgccag tattctacag gaaaaattgg gaagcctgaa tctgcggtgg caggaggtct 6660 gcaaacagct gtcagacaga aaaaagaggc tagaagaaca aaagaatatc ttgtcagaat 6720 ttcaaagaga tttaaatgaa tttgttttat ggttggagga agcagataac attgctagta 6780 tcccacttga acctggaaaa gagcagcaac taaaagaaaa gcttgagcaa gtcaagttac 6840 tggtggaaga gttgcccctg cgccagggaa ttctcaaaca attaaatgaa actggaggac 6900 ccgtgcttgt aagtgctccc ataagcccag aagagcaaga taaacttgaa aataagctca 6960 agcagacaaa tctccagtgg ataaaggttt ccagagcttt acctgagaaa caaggagaaa 7020 ttgaagctca aataaaagac cttgggcagc ttgaaaaaaa gcttgaagac cttgaagagc 7080 agttaaatca tctgctgctg tggttatctc ctattaggaa tcagttggaa atttataacc 7140 aaccaaacca agaaggacca tttgacgtta aggaaactga aatagcagtt caagctaaac 7200 aaccggatgt ggaagagatt ttgtctaaag ggcagcattt gtacaaggaa aaaccagcca 7260 ctcagccagt gaagaggaag ttagaagatc tgagctctga gtggaaggcg gtaaaccgtt 7320 tacttcaaga gctgagggca aagcagcctg acctagctcc tggactgacc actattggag 7380 cctctcctac tcagactgtt actctggtga cacaacctgt ggttactaag gaaactgcca 7440 tctccaaact agaaatgcca tcttccttga tgttggaggt acctgctctg gcagatttca 7500 accgggcttg gacagaactt accgactggc tttctctgct tgatcaagtt ataaaatcac 7560 agagggtgat ggtgggtgac cttgaggata tcaacgagat gatcatcaag cagaaggcaa 7620 caatgcagga tttggaacag aggcgtcccc agttggaaga actcattacc gctgcccaaa 7680 atttgaaaaa caagaccagc aatcaagagg ctagaacaat cattacggat cgaattgaaa 7740 gaattcagaa tcagtgggat gaagtacaag aacaccttca gaaccggagg caacagttga 7800 atgaaatgtt aaaggattca acacaatggc tggaagctaa ggaagaagct gagcaggtct 7860 taggacaggc cagagccaag cttgagtcat ggaaggaggg tccctataca gtagatgcaa 7920 tccaaaagaa aatcacagaa accaagcagt tggccaaaga cctccgccag tggcagacaa 7980 atgtagatgt ggcaaatgac ttggccctga aacttctccg ggattattct gcagatgata 8040 ccagaaaagt ccacatgata acagagaata tcaatgcctc ttggagaagc attcataaaa 8100 gggtgagtga gcgagaggct gctttggaag aaactcatag attactgcaa cagttccccc 8160 tggacctgga aaagtttctt gcctggctta cagaagctga aacaactgcc aatgtcctac 8220 aggatgctac ccgtaaggaa aggctcctag aagactccaa gggagtaaaa gagctgatga 8280 aacaatggca agacctccaa ggtgaaattg aagctcacac agatgtttat cacaacctgg 8340 atgaaaacag ccaaaaaatc ctgagatccc tggaaggttc cgatgatgca gtcctgttac 8400 aaagacgttt ggataacatg aacttcaagt ggagtgaact tcggaaaaag tctctcaaca 8460 ttaggtccca tttggaagcc agttctgacc agtggaagcg tctgcacctt tctctgcagg 8520 aacttctggt gtggctacag ctgaaagatg atgaattaag ccggcaggca cctattggag 8580 gcgactttcc agcagttcag aagcagaacg atgtacatag ggccttcaag agggaattga 8640 aaactaaaga acctgtaatc atgagtactc ttgagactgt acgaatattt ctgacagagc 8700 agcctttgga aggactagag aaactctacc aggagcccag agagctgcct cctgaggaga 8760 gagcccagaa tgtcactcgg cttctacgaa agcaggctga ggaggtcaat actgagtggg 8820 aaaaattgaa cctgcactcc gctgactggc agagaaaaat agatgagacc cttgaaagac 8880 tccgggaact tcaagaggcc acggatgagc tggacctcaa gctgcgccaa gctgaggtga 8940 tcaagggatc ctggcagccc gtgggcgatc tcctcattga ctctctccaa gatcacctcg 9000 agaaagtcaa ggcacttcga ggagaaattg cgcctctgaa agagaacgtg agccacgtca 9060 atgaccttgc tcgccagctt accactttgg gcattcagct ctcaccgtat aacctcagca 9120 ctctggaaga cctgaacacc agatggaagc ttctgcaggt ggccgtcgag gaccgagtca 9180 ggcagctgca tgaagcccac agggactttg gtccagcatc tcagcacttt ctttccacgt 9240 ctgtccaggg tccctgggag agagccatct cgccaaacaa agtgccctac tatatcaacc 9300 acgagactca aacaacttgc tgggaccatc ccaaaatgac agagctctac cagtctttag 9360 ctgacctgaa taatgtcaga ttctcagctt ataggactgc catgaaactc cgaagactgc 9420 agaaggccct ttgcttggat ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc 9480 acaacctcaa gcaaaatgac cagcccatgg atatcctgca gattattaat tgtttgacca 9540 ctatttatga ccgcctggag caagagcaca acaatttggt caacgtccct ctctgcgtgg 9600 atatgtgtct gaactggctg ctgaatgttt atgatacggg acgaacaggg aggatccgtg 9660 tcctgtcttt taaaactggc atcatttccc tgtgtaaagc acatttggaa gacaagtaca 9720 gatacctttt caagcaagtg gcaagttcaa caggattttg tgaccagcgc aggctgggcc 9780 tccttctgca tgattctatc caaattccaa gacagttggg tgaagttgca tcctttgggg 9840 gcagtaacat tgagccaagt gtccggagct gcttccaatt tgctaataat aagccagaga 9900 tcgaagcggc cctcttccta gactggatga gactggaacc ccagtccatg gtgtggctgc 9960 ccgtcctgca cagagtggct gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct 10020 gcaaagagtg tccaatcatt ggattcaggt acaggagtct aaagcacttt aattatgaca 10080 tctgccaaag ctgctttttt tctggtcgag ttgcaaaagg ccataaaatg cactatccca 10140 tggtggaata ttgcactccg actacatcag gagaagatgt tcgagacttt gccaaggtac 10200 taaaaaacaa atttcgaacc aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc 10260 cagtgcagac tgtcttagag ggggacaaca tggaaactcc cgttactctg atcaacttct 10320 ggccagtaga ttctgcgcct gcctcgtccc ctcagctttc acacgatgat actcattcac 10380 gcattgaaca ttatgctagc aggctagcag aaatggaaaa cagcaatgga tcttatctaa 10440 atgatagcat ctctcctaat gagagcatag atgatgaaca tttgttaatc cagcattact 10500 gccaaagttt gaaccaggac tcccccctga gccagcctcg tagtcctgcc cagatcttga 10560 tttccttaga gagtgaggaa agaggggagc tagagagaat cctagcagat cttgaggaag 10620 aaaacaggaa tctgcaagca gaatatgacc gtctaaagca gcagcacgaa cataaaggcc 10680 tgtccccact gccgtcccct cctgaaatga tgcccacctc tccccagagt ccccgggatg 10740 ctgagctcat tgctgaggcc aagctactgc gtcaacacaa aggccgcctg gaagccagga 10800 tgcaaatcct ggaagaccac aataaacagc tggagtcaca gttacacagg ctaaggcagc 10860 tgctggagca accccaggca gaggccaaag tgaatggcac aacggtgtcc tctccttcta 10920 cctctctaca gaggtccgac agcagtcagc ctatgctgct ccgagtggtt ggcagtcaaa 10980 cttcggactc catgggtgag gaagatcttc tcagtcctcc ccaggacaca agcacagggt 11040 tagaggaggt gatggagcaa ctcaacaact ccttccctag ttcaagagga cacaatgtag 11100 gaagtctttt ccacatggca gatgatttgg gcagagcgat ggagtcctta gtatcagtca 11160 tgacagatga agaaggagca gaataaatgt tttacaactc ctgattcccg catggttttt 11220 ataatattca tacaacaaag aggattagac agtaagagtt tacaagaaat aaatctatat 11280 ttttgtgaag ggtagtggta ttatactgta gatttcagta gtttctaagt ctgttattgt 11340 tttgttaaca atggcaggtt ttacacgtct atgcaattgt acaaaaaagt tataagaaaa 11400 ctacatgtaa aatcttgata gctaaataac ttgccatttc tttatatgga acgcattttg 11460 ggttgtttaa aaatttataa cagttataaa gaaagattgt aaactaaagt gtgctttata 11520 aaaaaaagtt gtttataaaa acccctaaaa acaaaacaaa cacacacaca cacacataca 11580 cacacacaca caaaactttg aggcagcgca ttgttttgca tccttttggc gtgatatcca 11640 tatgaaattc atggcttttt ctttttttgc atattaaaga taagacttcc tctaccacca 11700 caccaaatga ctactacaca ctgctcattt gagaactgtc agctgagtgg ggcaggcttg 11760 agttttcatt tcatatatct atatgtctat aagtatataa atactatagt tatatagata 11820 aagagatacg aatttctata gactgacttt ttccattttt taaatgttca tgtcacatcc 11880 taatagaaag aaattacttc tagtcagtca tccaggctta cctgcttggt ctagaatgga 11940 tttttcccgg agccggaagc caggaggaaa ctacaccaca ctaaaacatt gtctacagct 12000 ccagatgttt ctcattttaa acaactttcc actgacaacg aaagtaaagt aaagtattgg 12060 atttttttaa agggaacatg tgaatgaata cacaggactt attatatcag agtgagtaat 12120 cggttggttg gttgattgat tgattgattg atacattcag cttcctgctg ctagcaatgc 12180 cacgatttag atttaatgat gcttcagtgg aaatcaatca gaaggtattc tgaccttgtg 12240 aacatcagaa ggtatttttt aactcccaag cagtagcagg acgatgatag ggctggaggg 12300 ctatggattc ccagcccatc cctgtgaagg agtaggccac tctttaagtg aaggattgga 12360 tgattgttca taatacataa agttctctgt aattacaact aaattattat gccctcttct 12420 cacagtcaaa aggaactggg tggtttggtt tttgttgctt ttttagattt attgtcccat 12480 gtgggatgag tttttaaatg ccacaagaca taatttaaaa taaataaact ttgggaaaag 12540 gtgtaaaaca gtagccccat cacatttgtg atactgacag gtatcaaccc agaagcccat 12600 gaactgtgtt tccatccttt gcatttctct gcgagtagtt ccacacaggt ttgtaagtaa 12660 gtaagaaaga aggcaaattg attcaaatgt tacaaaaaaa cccttcttgg tggattagac 12720 aggttaaata tataaacaaa caaacaaaaa ttgctcaaaa aagaggagaa aagctcaaga 12780 ggaaaagcta aggactggta ggaaaaagct ttactctttc atgccatttt atttcttttt 12840 gatttttaaa tcattcattc aatagatacc accgtgtgac ctataatttt gcaaatctgt 12900 tacctctgac atcaagtgta attagctttt ggagagtggg ctgacatcaa gtgtaattag 12960 cttttggaga gtgggttttg tccattatta ataattaatt aattaacatc aaacacggct 13020 tctcatgcta tttctacctc actttggttt tggggtgttc ctgataattg tgcacacctg 13080 agttcacagc ttcaccactt gtccattgcg ttattttctt tttcctttat aattctttct 13140 ttttccttca taattttcaa aagaaaaccc aaagctctaa ggtaacaaat taccaaatta 13200 catgaagatt tggtttttgt cttgcatttt tttcctttat gtgacgctgg accttttctt 13260 tacccaagga tttttaaaac tcagatttaa aacaaggggt tactttacat cctactaaga 13320 agtttaagta agtaagtttc attctaaaat cagaggtaaa tagagtgcat aaataatttt 13380 gttttaatct ttttgttttt cttttagaca cattagctct ggagtgagtc tgtcataata 13440 tttgaacaaa aattgagagc tttattgctg cattttaagc ataattaatt tggacattat 13500 ttcgtgttgt gttctttata accaccaagt attaaactgt aaatcataat gtaactgaag 13560 cataaacatc acatggcatg ttttgtcatt gttttcaggt actgagttct tacttgagta 13620 tcataatata ttgtgtttta acaccaacac tgtaacattt acgaattatt tttttaaact 13680 tcagttttac tgcattttca caacatatca gacttcacca aatatatgcc ttactattgt 13740 attatagtac tgctttactg tgtatctcaa taaagcacgc agttatgtta caaaaaagta 13800 <210> 41 <211> 3662 <212> PRT <213> Homo sapiens <400> 41 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Asn Glu Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln 1775 1780 1785 Arg Gly Asp Asn Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg 1790 1795 1800 Glu Glu Ile Lys Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn 1805 1810 1815 Ala Leu Lys Asp Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu 1820 1825 1830 Ile Ser His Gln Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu 1835 1840 1845 Leu Lys Cys Leu Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro 1850 1855 1860 Glu Pro Arg Asp Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu 1865 1870 1875 Gln Lys Lys Lys Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu 1880 1885 1890 Gly Leu Ser Glu Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln 1895 1900 1905 Ile Gln Leu Ser Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala 1910 1915 1920 Gln Phe Arg Arg Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu 1925 1930 1935 Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser 1940 1945 1950 Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln 1955 1960 1965 Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys 1970 1975 1980 Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys 1985 1990 1995 Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile 2000 2005 2010 Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val 2015 2020 2025 Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln 2030 2035 2040 Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe 2045 2050 2055 Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys 2060 2065 2070 Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys 2075 2080 2085 Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr 2090 2095 2100 Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val 2105 2110 2115 Arg Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser 2120 2125 2130 Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn 2135 2140 2145 Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys 2150 2155 2160 Arg Leu Glu Glu Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp 2165 2170 2175 Leu Asn Glu Phe Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala 2180 2185 2190 Ser Ile Pro Leu Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys 2195 2200 2205 Leu Glu Gln Val Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln 2210 2215 2220 Gly Ile Leu Lys Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val 2225 2230 2235 Ser Ala Pro Ile Ser Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys 2240 2245 2250 Leu Lys Gln Thr Asn Leu Gln Trp Ile Lys Val Ser Arg Ala Leu 2255 2260 2265 Pro Glu Lys Gln Gly Glu Ile Glu Ala Gln Ile Lys Asp Leu Gly 2270 2275 2280 Gln Leu Glu Lys Lys Leu Glu Asp Leu Glu Glu Gln Leu Asn His 2285 2290 2295 Leu Leu Leu Trp Leu Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr 2300 2305 2310 Asn Gln Pro Asn Gln Glu Gly Pro Phe Asp Val Lys Glu Thr Glu 2315 2320 2325 Ile Ala Val Gln Ala Lys Gln Pro Asp Val Glu Glu Ile Leu Ser 2330 2335 2340 Lys Gly Gln His Leu Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val 2345 2350 2355 Lys Arg Lys Leu Glu Asp Leu Ser Ser Glu Trp Lys Ala Val Asn 2360 2365 2370 Arg Leu Leu Gln Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro 2375 2380 2385 Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu 2390 2395 2400 Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu 2405 2410 2415 Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp 2420 2425 2430 Phe Asn Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu 2435 2440 2445 Asp Gln Val Ile Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu 2450 2455 2460 Asp Ile Asn Glu Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp 2465 2470 2475 Leu Glu Gln Arg Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala 2480 2485 2490 Gln Asn Leu Lys Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile 2495 2500 2505 Ile Thr Asp Arg Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val 2510 2515 2520 Gln Glu His Leu Gln Asn Arg Arg Gln Gln Leu Asn Glu Met Leu 2525 2530 2535 Lys Asp Ser Thr Gln Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln 2540 2545 2550 Val Leu Gly Gln Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly 2555 2560 2565 Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys 2570 2575 2580 Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val 2585 2590 2595 Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp 2600 2605 2610 Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile Asn Ala Ser 2615 2620 2625 Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu 2630 2635 2640 Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu 2645 2650 2655 Lys Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val 2660 2665 2670 Leu Gln Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys 2675 2680 2685 Gly Val Lys Glu Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu 2690 2695 2700 Ile Glu Ala His Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser 2705 2710 2715 Gln Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu 2720 2725 2730 Leu Gln Arg Arg Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu 2735 2740 2745 Arg Lys Lys Ser Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser 2750 2755 2760 Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val 2765 2770 2775 Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile 2780 2785 2790 Gly Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val His Arg 2795 2800 2805 Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser 2810 2815 2820 Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu 2825 2830 2835 Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu 2840 2845 2850 Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu 2855 2860 2865 Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp 2870 2875 2880 Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Arg Glu Leu 2885 2890 2895 Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu 2900 2905 2910 Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp 2915 2920 2925 Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu 2930 2935 2940 Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala 2945 2950 2955 Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu 2960 2965 2970 Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val 2975 2980 2985 Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp 2990 2995 3000 Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly 3005 3010 3015 Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile 3020 3025 3030 Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr 3035 3040 3045 Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser 3050 3055 3060 Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu 3065 3070 3075 Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp 3080 3085 3090 Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln 3095 3100 3105 Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 3110 3115 3120 His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu 3125 3130 3135 Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile 3140 3145 3150 Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala 3155 3160 3165 His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser 3170 3175 3180 Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His 3185 3190 3195 Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe 3200 3205 3210 Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe 3215 3220 3225 Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp 3230 3235 3240 Met Arg Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val Leu His 3245 3250 3255 Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn 3260 3265 3270 Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu 3275 3280 3285 Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly 3290 3295 3300 Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met Val Glu Tyr 3305 3310 3315 Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys 3320 3325 3330 Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His 3335 3340 3345 Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 3350 3355 3360 Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp 3365 3370 3375 Ser Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His 3380 3385 3390 Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn 3395 3400 3405 Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser 3410 3415 3420 Ile Asp Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu 3425 3430 3435 Asn Gln Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile 3440 3445 3450 Leu Ile Ser Leu Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile 3455 3460 3465 Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr 3470 3475 3480 Asp Arg Leu Lys Gln Gln His Glu His Lys Gly Leu Ser Pro Leu 3485 3490 3495 Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro Gln Ser Pro Arg 3500 3505 3510 Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys 3515 3520 3525 Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys 3530 3535 3540 Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln 3545 3550 3555 Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro 3560 3565 3570 Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu 3575 3580 3585 Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp 3590 3595 3600 Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val 3605 3610 3615 Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly His Asn 3620 3625 3630 Val Gly Ser Leu Phe His Met Ala Asp Asp Leu Gly Arg Ala Met 3635 3640 3645 Glu Ser Leu Val Ser Val Met Thr Asp Glu Glu Gly Ala Glu 3650 3655 3660 <210> 42 <211> 13785 <212> DNA <213> Homo sapiens <400> 42 actttccccc tacaggactc agatctggga ggcaattacc ttcggagaaa aacgaatagg 60 aaaaactgaa gtgttacttt ttttaaagct gctgaagttt gttggtttct cattgttttt 120 aagcctactg gagcaataaa gtttgaagaa cttttaccag gtttttttta tcgctgcctt 180 gatatacact tttcaaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag 240 atgttcaaaa gaaaacattc acaaaatggg taaatgcaca attttctaag tttgggaagc 300 agcatattga gaacctcttc agtgacctac aggatgggag gcgcctccta gacctcctcg 360 aaggcctgac agggcaaaaa ctgccaaaag aaaaaggatc cacaagagtt catgccctga 420 acaatgtcaa caaggcactg cgggttttgc agaacaataa tgttgattta gtgaatattg 480 gaagtactga catcgtagat ggaaatcata aactgactct tggtttgatt tggaatataa 540 tcctccactg gcaggtcaaa aatgtaatga aaaatatcat ggctggattg caacaaacca 600 acagtgaaaa gattctcctg agctgggtcc gacaatcaac tcgtaattat ccacaggtta 660 atgtaatcaa cttcaccacc agctggtctg atggcctggc tttgaatgct ctcatccata 720 gtcataggcc agacctattt gactggaata gtgtggtttg ccagcagtca gccacacaac 780 gactggaaca tgcattcaac atcgccagat atcaattagg catagagaaa ctactcgatc 840 ctgaagatgt tgataccacc tatccagata agaagtccat cttaatgtac atcacatcac 900 tcttccaagt tttgcctcaa caagtgagca ttgaagccat ccaggaagtg gaaatgttgc 960 caaggccacc taaagtgact aaagaagaac attttcagtt acatcatcaa atgcactatt 1020 ctcaacagat cacggtcagt ctagcacagg gatatgagag aacttcttcc cctaagcctc 1080 gattcaagag ctatgcctac acacaggctg cttatgtcac cacctctgac cctacacgga 1140 gcccatttcc ttcacagcat ttggaagctc ctgaagacaa gtcatttggc agttcattga 1200 tggagagtga agtaaacctg gaccgttatc aaacagcttt agaagaagta ttatcgtggc 1260 ttctttctgc tgaggacaca ttgcaagcac aaggagagat ttctaatgat gtggaagtgg 1320 tgaaagacca gtttcatact catgaggggt acatgatgga tttgacagcc catcagggcc 1380 gggttggtaa tattctacaa ttgggaagta agctgattgg aacaggaaaa ttatcagaag 1440 atgaagaaac tgaagtacaa gagcagatga atctcctaaa ttcaagatgg gaatgcctca 1500 gggtagctag catggaaaaa caaagcaatt tacatagagt tttaatggat ctccagaatc 1560 agaaactgaa agagttgaat gactggctaa caaaaacaga agaaagaaca aggaaaatgg 1620 aggaagagcc tcttggacct gatcttgaag acctaaaacg ccaagtacaa caacataagg 1680 tgcttcaaga agatctagaa caagaacaag tcagggtcaa ttctctcact cacatggtgg 1740 tggtagttga tgaatctagt ggagatcacg caactgctgc tttggaagaa caacttaagg 1800 tattgggaga tcgatgggca aacatctgta gatggacaga agaccgctgg gttcttttac 1860 aagacatcct tctcaaatgg caacgtctta ctgaagaaca gtgccttttt agtgcatggc 1920 tttcagaaaa agaagatgca gtgaacaaga ttcacacaac tggctttaaa gatcaaaatg 1980 aaatgttatc aagtcttcaa aaactggccg ttttaaaagc ggatctagaa aagaaaaagc 2040 aatccatggg caaactgtat tcactcaaac aagatcttct ttcaacactg aagaataagt 2100 cagtgaccca gaagacggaa gcatggctgg ataactttgc ccggtgttgg gataatttag 2160 tccaaaaact tgaaaagagt acagcacaga tttcacaggc tgtcaccacc actcagccat 2220 cactaacaca gacaactgta atggaaacag taactacggt gaccacaagg gaacagatcc 2280 tggtaaagca tgctcaagag gaacttccac caccacctcc ccaaaagaag aggcagatta 2340 ctgtggattc tgaaattagg aaaaggttgg atgttgatat aactgaactt cacagctgga 2400 ttactcgctc agaagctgtg ttgcagagtc ctgaatttgc aatctttcgg aaggaaggca 2460 acttctcaga cttaaaagaa aaagtcaatg ccatagagcg agaaaaagct gagaagttca 2520 gaaaactgca agatgccagc agatcagctc aggccctggt ggaacagatg gtgaatgagg 2580 gtgttaatgc agatagcatc aaacaagcct cagaacaact gaacagccgg tggatcgaat 2640 tctgccagtt gctaagtgag agacttaact ggctggagta tcagaacaac atcatcgctt 2700 tctataatca gctacaacaa ttggagcaga tgacaactac tgctgaaaac tggttgaaaa 2760 tccaacccac caccccatca gagccaacag caattaaaag tcagttaaaa atttgtaagg 2820 atgaagtcaa ccggctatca gatcttcaac ctcaaattga acgattaaaa attcaaagca 2880 tagccctgaa agagaaagga caaggaccca tgttcctgga tgcagacttt gtggccttta 2940 caaatcattt taagcaagtc ttttctgatg tgcaggccag agagaaagag ctacagacaa 3000 tttttgacac tttgccacca atgcgctatc aggagaccat gagtgccatc aggacatggg 3060 tccagcagtc agaaaccaaa ctctccatac ctcaacttag tgtcaccgac tatgaaatca 3120 tggagcagag actcggggaa ttgcaggctt tacaaagttc tctgcaagag caacaaagtg 3180 gcctatacta tctcagcacc actgtgaaag agatgtcgaa gaaagcgccc tctgaaatta 3240 gccggaaata tcaatcagaa tttgaagaaa ttgagggacg ctggaagaag ctctcctccc 3300 agctggttga gcattgtcaa aagctagagg agcaaatgaa taaactccga aaaattcaga 3360 atcacataca aaccctgaag aaatggatgg ctgaagttga tgtttttctg aaggaggaat 3420 ggcctgccct tggggattca gaaattctaa aaaagcagct gaaacagtgc agacttttag 3480 tcagtgatat tcagacaatt cagcccagtc taaacagtgt caatgaaggt gggcagaaga 3540 taaagaatga agcagagcca gagtttgctt cgagacttga gacagaactc aaagaactta 3600 acactcagtg ggatcacatg tgccaacagg tctatgccag aaaggaggcc ttgaagggag 3660 gtttggagaa aactgtaagc ctccagaaag atctatcaga gatgcacgaa tggatgacac 3720 aagctgaaga agagtatctt gagagagatt ttgaatataa aactccagat gaattacaga 3780 aagcagttga agagatgaag agagctaaag aagaggccca acaaaaagaa gcgaaagtga 3840 aactccttac tgagtctgta aatagtgtca tagctcaagc tccacctgta gcacaagagg 3900 ccttaaaaaa ggaacttgaa actctaacca ccaactacca gtggctctgc actaggctga 3960 atgggaaatg caagactttg gaagaagttt gggcatgttg gcatgagtta ttgtcatact 4020 tggagaaagc aaacaagtgg ctaaatgaag tagaatttaa acttaaaacc actgaaaaca 4080 ttcctggcgg agctgaggaa atctctgagg tgctagattc acttgaaaat ttgatgcgac 4140 attcagagga taacccaaat cagattcgca tattggcaca gaccctaaca gatggcggag 4200 tcatggatga gctaatcaat gaggaacttg agacatttaa ttctcgttgg agggaactac 4260 atgaagaggc tgtaaggagg caaaagttgc ttgaacagag catccagtct gcccaggaga 4320 ctgaaaaatc cttacactta atccaggagt ccctcacatt cattgacaag cagttggcag 4380 cttatattgc agacaaggtg gacgcagctc aaatgcctca ggaagcccag aaaatccaat 4440 ctgatttgac aagtcatgag atcagtttag aagaaatgaa gaaacataat caggggaagg 4500 aggctgccca aagagtcctg tctcagattg atgttgcaca gaaaaaatta caagatgtct 4560 ccatgaagtt tcgattattc cagaaaccag ccaattttga gcagcgtcta caagaaagta 4620 agatgatttt agatgaagtg aagatgcact tgcctgcatt ggaaacaaag agtgtggaac 4680 aggaagtagt acagtcacag ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag 4740 tgaagtctga agtggaaatg gtgataaaga ctggacgtca gattgtacag aaaaagcaga 4800 cggaaaatcc caaagaactt gatgaaagag taacagcttt gaaattgcat tataatgagc 4860 tgggagcaaa ggtaacagaa agaaagcaac agttggagaa atgcttgaaa ttgtcccgta 4920 agatgcgaaa ggaaatgaat gtcttgacag aatggctggc agctacagat atggaattga 4980 caaagagatc agcagttgaa ggaatgccta gtaatttgga ttctgaagtt gcctggggaa 5040 aggctactca aaaagagatt gagaaacaga aggtgcacct gaagagtatc acagaggtag 5100 gagaggcctt gaaaacagtt ttgggcaaga aggagacgtt ggtggaagat aaactcagtc 5160 ttctgaatag taactggata gctgtcacct cccgagcaga agagtggtta aatcttttgt 5220 tggaatacca gaaacacatg gaaacttttg accagaatgt ggaccacatc acaaagtgga 5280 tcattcaggc tgacacactt ttggatgaat cagagaaaaa gaaaccccag caaaaagaag 5340 acgtgcttaa gcgtttaaag gcagaactga atgacatacg cccaaaggtg gactctacac 5400 gtgaccaagc agcaaacttg atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc 5460 cccaaatctc agagctcaac catcgatttg cagccatttc acacagaatt aagactggaa 5520 aggcctccat tcctttgaag gaattggagc agtttaactc agatatacaa aaattgcttg 5580 aaccactgga ggctgaaatt cagcaggggg tgaatctgaa agaggaagac ttcaataaag 5640 atatggattt gaggtctcaa agaagaaaaa aggctctaga aatttctcat cagtggtatc 5700 agtacaagag gcaggctgat gatctcctga aatgcttgga tgacattgaa aaaaaattag 5760 ccagcctacc tgagcccaga gatgaaagga aaataaagga aattgatcgg gaattgcaga 5820 agaagaaaga ggagctgaat gcagtgcgta ggcaagctga gggcttgtct gaggatgggg 5880 ccgcaatggc agtggagcca actcagatcc agctcagcaa gcgctggcgg gaaattgaga 5940 gcaaatttgc tcagtttcga agactcaact ttgcacaaat tcacactgtc cgtgaagaaa 6000 cgatgatggt gatgactgaa gacatgcctt tggaaatttc ttatgtgcct tctacttatt 6060 tgactgaaat cactcatgtc tcacaagccc tattagaagt ggaacaactt ctcaatgctc 6120 ctgacctctg tgctaaggac tttgaagatc tctttaagca agaggagtct ctgaagaata 6180 taaaagatag tctacaacaa agctcaggtc ggattgacat tattcatagc aagaagacag 6240 cagcattgca aagtgcaacg cctgtggaaa gggtgaagct acaggaagct ctctcccagc 6300 ttgatttcca atgggaaaaa gttaacaaaa tgtacaagga ccgacaaggg cgatttgaca 6360 gatctgttga gaaatggcgg cgttttcatt atgatataaa gatatttaat cagtggctaa 6420 cagaagctga acagtttctc agaaagacac aaattcctga gaattgggaa catgctaaat 6480 acaaatggta tcttaaggaa ctccaggatg gcattgggca gcggcaaact gttgtcagaa 6540 cattgaatgc aactggggaa gaaataattc agcaatcctc aaaaacagat gccagtattc 6600 tacaggaaaa attgggaagc ctgaatctgc ggtggcagga ggtctgcaaa cagctgtcag 6660 acagaaaaaa gaggctagaa gaacaaaaga atatcttgtc agaatttcaa agagatttaa 6720 atgaatttgt tttatggttg gaggaagcag ataacattgc tagtatccca cttgaacctg 6780 gaaaagagca gcaactaaaa gaaaagcttg agcaagtcaa gttactggtg gaagagttgc 6840 ccctgcgcca gggaattctc aaacaattaa atgaaactgg aggacccgtg cttgtaagtg 6900 ctcccataag cccagaagag caagataaac ttgaaaataa gctcaagcag acaaatctcc 6960 agtggataaa ggtttccaga gctttacctg agaaacaagg agaaattgaa gctcaaataa 7020 aagaccttgg gcagcttgaa aaaaagcttg aagaccttga agagcagtta aatcatctgc 7080 tgctgtggtt atctcctatt aggaatcagt tggaaattta taaccaacca aaccaagaag 7140 gaccatttga cgttaaggaa actgaaatag cagttcaagc taaacaaccg gatgtggaag 7200 agattttgtc taaagggcag catttgtaca aggaaaaacc agccactcag ccagtgaaga 7260 ggaagttaga agatctgagc tctgagtgga aggcggtaaa ccgtttactt caagagctga 7320 gggcaaagca gcctgaccta gctcctggac tgaccactat tggagcctct cctactcaga 7380 ctgttactct ggtgacacaa cctgtggtta ctaaggaaac tgccatctcc aaactagaaa 7440 tgccatcttc cttgatgttg gaggtacctg ctctggcaga tttcaaccgg gcttggacag 7500 aacttaccga ctggctttct ctgcttgatc aagttataaa atcacagagg gtgatggtgg 7560 gtgaccttga ggatatcaac gagatgatca tcaagcagaa ggcaacaatg caggatttgg 7620 aacagaggcg tccccagttg gaagaactca ttaccgctgc ccaaaatttg aaaaacaaga 7680 ccagcaatca agaggctaga acaatcatta cggatcgaat tgaaagaatt cagaatcagt 7740 gggatgaagt acaagaacac cttcagaacc ggaggcaaca gttgaatgaa atgttaaagg 7800 attcaacaca atggctggaa gctaaggaag aagctgagca ggtcttagga caggccagag 7860 ccaagcttga gtcatggaag gagggtccct atacagtaga tgcaatccaa aagaaaatca 7920 cagaaaccaa gcagttggcc aaagacctcc gccagtggca gacaaatgta gatgtggcaa 7980 atgacttggc cctgaaactt ctccgggatt attctgcaga tgataccaga aaagtccaca 8040 tgataacaga gaatatcaat gcctcttgga gaagcattca taaaagggtg agtgagcgag 8100 aggctgcttt ggaagaaact catagattac tgcaacagtt ccccctggac ctggaaaagt 8160 ttcttgcctg gcttacagaa gctgaaacaa ctgccaatgt cctacaggat gctacccgta 8220 aggaaaggct cctagaagac tccaagggag taaaagagct gatgaaacaa tggcaagacc 8280 tccaaggtga aattgaagct cacacagatg tttatcacaa cctggatgaa aacagccaaa 8340 aaatcctgag atccctggaa ggttccgatg atgcagtcct gttacaaaga cgtttggata 8400 acatgaactt caagtggagt gaacttcgga aaaagtctct caacattagg tcccatttgg 8460 aagccagttc tgaccagtgg aagcgtctgc acctttctct gcaggaactt ctggtgtggc 8520 tacagctgaa agatgatgaa ttaagccggc aggcacctat tggaggcgac tttccagcag 8580 ttcagaagca gaacgatgta catagggcct tcaagaggga attgaaaact aaagaacctg 8640 taatcatgag tactcttgag actgtacgaa tatttctgac agagcagcct ttggaaggac 8700 tagagaaact ctaccaggag cccagagagc tgcctcctga ggagagagcc cagaatgtca 8760 ctcggcttct acgaaagcag gctgaggagg tcaatactga gtgggaaaaa ttgaacctgc 8820 actccgctga ctggcagaga aaaatagatg agacccttga aagactccgg gaacttcaag 8880 aggccacgga tgagctggac ctcaagctgc gccaagctga ggtgatcaag ggatcctggc 8940 agcccgtggg cgatctcctc attgactctc tccaagatca cctcgagaaa gtcaaggcac 9000 ttcgaggaga aattgcgcct ctgaaagaga acgtgagcca cgtcaatgac cttgctcgcc 9060 agcttaccac tttgggcatt cagctctcac cgtataacct cagcactctg gaagacctga 9120 acaccagatg gaagcttctg caggtggccg tcgaggaccg agtcaggcag ctgcatgaag 9180 cccacaggga ctttggtcca gcatctcagc actttctttc cacgtctgtc cagggtccct 9240 gggagagagc catctcgcca aacaaagtgc cctactatat caaccacgag actcaaacaa 9300 cttgctggga ccatcccaaa atgacagagc tctaccagtc tttagctgac ctgaataatg 9360 tcagattctc agcttatagg actgccatga aactccgaag actgcagaag gccctttgct 9420 tggatctctt gagcctgtca gctgcatgtg atgccttgga ccagcacaac ctcaagcaaa 9480 atgaccagcc catggatatc ctgcagatta ttaattgttt gaccactatt tatgaccgcc 9540 tggagcaaga gcacaacaat ttggtcaacg tccctctctg cgtggatatg tgtctgaact 9600 ggctgctgaa tgtttatgat acgggacgaa cagggaggat ccgtgtcctg tcttttaaaa 9660 ctggcatcat ttccctgtgt aaagcacatt tggaagacaa gtacagatac cttttcaagc 9720 aagtggcaag ttcaacagga ttttgtgacc agcgcaggct gggcctcctt ctgcatgatt 9780 ctatccaaat tccaagacag ttgggtgaag ttgcatcctt tgggggcagt aacattgagc 9840 caagtgtccg gagctgcttc caatttgcta ataataagcc agagatcgaa gcggccctct 9900 tcctagactg gatgagactg gaaccccagt ccatggtgtg gctgcccgtc ctgcacagag 9960 tggctgctgc agaaactgcc aagcatcagg ccaaatgtaa catctgcaaa gagtgtccaa 10020 tcattggatt caggtacagg agtctaaagc actttaatta tgacatctgc caaagctgct 10080 ttttttctgg tcgagttgca aaaggccata aaatgcacta tcccatggtg gaatattgca 10140 ctccgactac atcaggagaa gatgttcgag actttgccaa ggtactaaaa aacaaatttc 10200 gaaccaaaag gtattttgcg aagcatcccc gaatgggcta cctgccagtg cagactgtct 10260 tagaggggga caacatggaa actcccgtta ctctgatcaa cttctggcca gtagattctg 10320 cgcctgcctc gtcccctcag ctttcacacg atgatactca ttcacgcatt gaacattatg 10380 ctagcaggct agcagaaatg gaaaacagca atggatctta tctaaatgat agcatctctc 10440 ctaatgagag catagatgat gaacatttgt taatccagca ttactgccaa agtttgaacc 10500 aggactcccc cctgagccag cctcgtagtc ctgcccagat cttgatttcc ttagagagtg 10560 aggaaagagg ggagctagag agaatcctag cagatcttga ggaagaaaac aggaatctgc 10620 aagcagaata tgaccgtcta aagcagcagc acgaacataa aggcctgtcc ccactgccgt 10680 cccctcctga aatgatgccc acctctcccc agagtccccg ggatgctgag ctcattgctg 10740 aggccaagct actgcgtcaa cacaaaggcc gcctggaagc caggatgcaa atcctggaag 10800 accacaataa acagctggag tcacagttac acaggctaag gcagctgctg gagcaacccc 10860 aggcagaggc caaagtgaat ggcacaacgg tgtcctctcc ttctacctct ctacagaggt 10920 ccgacagcag tcagcctatg ctgctccgag tggttggcag tcaaacttcg gactccatgg 10980 gtgaggaaga tcttctcagt cctccccagg acacaagcac agggttagag gaggtgatgg 11040 agcaactcaa caactccttc cctagttcaa gaggacacaa tgtaggaagt cttttccaca 11100 tggcagatga tttgggcaga gcgatggagt ccttagtatc agtcatgaca gatgaagaag 11160 gagcagaata aatgttttac aactcctgat tcccgcatgg tttttataat attcatacaa 11220 caaagaggat tagacagtaa gagtttacaa gaaataaatc tatatttttg tgaagggtag 11280 tggtattata ctgtagattt cagtagtttc taagtctgtt attgttttgt taacaatggc 11340 aggttttaca cgtctatgca attgtacaaa aaagttataa gaaaactaca tgtaaaatct 11400 tgatagctaa ataacttgcc atttctttat atggaacgca ttttgggttg tttaaaaatt 11460 tataacagtt ataaagaaag attgtaaact aaagtgtgct ttataaaaaa aagttgttta 11520 taaaaacccc taaaaacaaa acaaacacac acacacacac atacacacac acacacaaaa 11580 ctttgaggca gcgcattgtt ttgcatcctt ttggcgtgat atccatatga aattcatggc 11640 tttttctttt tttgcatatt aaagataaga cttcctctac caccacacca aatgactact 11700 acacactgct catttgagaa ctgtcagctg agtggggcag gcttgagttt tcatttcata 11760 tatctatatg tctataagta tataaatact atagttatat agataaagag atacgaattt 11820 ctatagactg actttttcca ttttttaaat gttcatgtca catcctaata gaaagaaatt 11880 acttctagtc agtcatccag gcttacctgc ttggtctaga atggattttt cccggagccg 11940 gaagccagga ggaaactaca ccacactaaa acattgtcta cagctccaga tgtttctcat 12000 tttaaacaac tttccactga caacgaaagt aaagtaaagt attggatttt tttaaaggga 12060 acatgtgaat gaatacacag gacttattat atcagagtga gtaatcggtt ggttggttga 12120 ttgattgatt gattgataca ttcagcttcc tgctgctagc aatgccacga tttagattta 12180 atgatgcttc agtggaaatc aatcagaagg tattctgacc ttgtgaacat cagaaggtat 12240 tttttaactc ccaagcagta gcaggacgat gatagggctg gagggctatg gattcccagc 12300 ccatccctgt gaaggagtag gccactcttt aagtgaagga ttggatgatt gttcataata 12360 cataaagttc tctgtaatta caactaaatt attatgccct cttctcacag tcaaaaggaa 12420 ctgggtggtt tggtttttgt tgctttttta gatttattgt cccatgtggg atgagttttt 12480 aaatgccaca agacataatt taaaataaat aaactttggg aaaaggtgta aaacagtagc 12540 cccatcacat ttgtgatact gacaggtatc aacccagaag cccatgaact gtgtttccat 12600 cctttgcatt tctctgcgag tagttccaca caggtttgta agtaagtaag aaagaaggca 12660 aattgattca aatgttacaa aaaaaccctt cttggtggat tagacaggtt aaatatataa 12720 acaaacaaac aaaaattgct caaaaaagag gagaaaagct caagaggaaa agctaaggac 12780 tggtaggaaa aagctttact ctttcatgcc attttatttc tttttgattt ttaaatcatt 12840 cattcaatag ataccaccgt gtgacctata attttgcaaa tctgttacct ctgacatcaa 12900 gtgtaattag cttttggaga gtgggctgac atcaagtgta attagctttt ggagagtggg 12960 ttttgtccat tattaataat taattaatta acatcaaaca cggcttctca tgctatttct 13020 acctcacttt ggttttgggg tgttcctgat aattgtgcac acctgagttc acagcttcac 13080 cacttgtcca ttgcgttatt ttctttttcc tttataattc tttctttttc cttcataatt 13140 ttcaaaagaa aacccaaagc tctaaggtaa caaattacca aattacatga agatttggtt 13200 tttgtcttgc atttttttcc tttatgtgac gctggacctt ttctttaccc aaggattttt 13260 aaaactcaga tttaaaacaa ggggttactt tacatcctac taagaagttt aagtaagtaa 13320 gtttcattct aaaatcagag gtaaatagag tgcataaata attttgtttt aatctttttg 13380 tttttctttt agacacatta gctctggagt gagtctgtca taatatttga acaaaaattg 13440 agagctttat tgctgcattt taagcataat taatttggac attatttcgt gttgtgttct 13500 ttataaccac caagtattaa actgtaaatc ataatgtaac tgaagcataa acatcacatg 13560 gcatgttttg tcattgtttt caggtactga gttcttactt gagtatcata atatattgtg 13620 ttttaacacc aacactgtaa catttacgaa ttattttttt aaacttcagt tttactgcat 13680 tttcacaaca tatcagactt caccaaatat atgccttact attgtattat agtactgctt 13740 tactgtgtat ctcaataaag cacgcagtta tgttacaaaa aagta 13785 <210> 43 <211> 3657 <212> PRT <213> Homo sapiens <400> 43 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser 1775 1780 1785 Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln 1790 1795 1800 Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asp Leu 1805 1810 1815 Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln Trp 1820 1825 1830 Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu Asp 1835 1840 1845 Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp Glu 1850 1855 1860 Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys Glu 1865 1870 1875 Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu Asp 1880 1885 1890 Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser Lys 1895 1900 1905 Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg Leu 1910 1915 1920 Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val 1925 1930 1935 Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr 1940 1945 1950 Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu Val 1955 1960 1965 Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu 1970 1975 1980 Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp Ser 1985 1990 1995 Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys 2000 2005 2010 Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys Leu 2015 2020 2025 Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn 2030 2035 2040 Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu 2045 2050 2055 Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp 2060 2065 2070 Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu 2075 2080 2085 Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln 2090 2095 2100 Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala 2105 2110 2115 Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser 2120 2125 2130 Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu 2135 2140 2145 Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln 2150 2155 2160 Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe Val 2165 2170 2175 Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu Glu 2180 2185 2190 Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val Lys 2195 2200 2205 Leu Leu Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys Gln 2210 2215 2220 Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile Ser 2225 2230 2235 Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr Asn 2240 2245 2250 Leu Gln Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln Gly 2255 2260 2265 Glu Ile Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys Lys 2270 2275 2280 Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp Leu 2285 2290 2295 Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn Gln 2300 2305 2310 Glu Gly Pro Phe Asp Val Lys Glu Thr Glu Ile Ala Val Gln Ala 2315 2320 2325 Lys Gln Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His Leu 2330 2335 2340 Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu Glu 2345 2350 2355 Asp Leu Ser Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln Glu 2360 2365 2370 Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr Ile 2375 2380 2385 Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro Val 2390 2395 2400 Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser Ser 2405 2410 2415 Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala Trp 2420 2425 2430 Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile Lys 2435 2440 2445 Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu Met 2450 2455 2460 Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg Arg 2465 2470 2475 Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn 2480 2485 2490 Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile 2495 2500 2505 Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu Gln 2510 2515 2520 Asn Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr Gln 2525 2530 2535 Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln Ala 2540 2545 2550 Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp 2555 2560 2565 Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys Asp 2570 2575 2580 Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu Ala 2585 2590 2595 Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys Val 2600 2605 2610 His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile His 2615 2620 2625 Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His Arg 2630 2635 2640 Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp 2645 2650 2655 Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala Thr 2660 2665 2670 Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu Leu 2675 2680 2685 Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His Thr 2690 2695 2700 Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg 2705 2710 2715 Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu 2720 2725 2730 Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu 2735 2740 2745 Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg 2750 2755 2760 Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys 2765 2770 2775 Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro 2780 2785 2790 Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg Glu 2795 2800 2805 Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr Val 2810 2815 2820 Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys Leu 2825 2830 2835 Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn 2840 2845 2850 Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr Glu 2855 2860 2865 Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys Ile 2870 2875 2880 Asp Glu Thr Leu Glu Arg Leu Arg Glu Leu Gln Glu Ala Thr Asp 2885 2890 2895 Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser 2900 2905 2910 Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His 2915 2920 2925 Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys 2930 2935 2940 Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr 2945 2950 2955 Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp 2960 2965 2970 Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg 2975 2980 2985 Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser 2990 2995 3000 Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala 3005 3010 3015 Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln 3020 3025 3030 Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser 3035 3040 3045 Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala 3050 3055 3060 Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu 3065 3070 3075 Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys 3080 3085 3090 Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys Leu 3095 3100 3105 Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu Val 3110 3115 3120 Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn 3125 3130 3135 Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser Phe 3140 3145 3150 Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp Lys 3155 3160 3165 Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe Cys 3170 3175 3180 Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 3185 3190 3195 Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile 3200 3205 3210 Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro 3215 3220 3225 Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro 3230 3235 3240 Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala 3245 3250 3255 Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys 3260 3265 3270 Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr 3275 3280 3285 Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly 3290 3295 3300 His Lys Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr Thr 3305 3310 3315 Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn Lys 3320 3325 3330 Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly Tyr 3335 3340 3345 Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr Pro 3350 3355 3360 Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala Ser 3365 3370 3375 Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu His 3380 3385 3390 Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr 3395 3400 3405 Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu His 3410 3415 3420 Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro 3425 3430 3435 Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu 3440 3445 3450 Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu 3455 3460 3465 Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln 3470 3475 3480 Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu 3485 3490 3495 Met Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile 3500 3505 3510 Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala 3515 3520 3525 Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln 3530 3535 3540 Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala 3545 3550 3555 Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr Ser Leu Gln 3560 3565 3570 Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val Val Gly Ser 3575 3580 3585 Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu Ser Pro Pro 3590 3595 3600 Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln Leu Asn 3605 3610 3615 Asn Ser Phe Pro Ser Ser Arg Gly His Asn Val Gly Ser Leu Phe 3620 3625 3630 His Met Ala Asp Asp Leu Gly Arg Ala Met Glu Ser Leu Val Ser 3635 3640 3645 Val Met Thr Asp Glu Glu Gly Ala Glu 3650 3655 <210> 44 <211> 13625 <212> DNA <213> Homo sapiens <400> 44 actttccccc tacaggactc agatctggga ggcaattacc ttcggagaaa aacgaatagg 60 aaaaactgaa gtgttacttt ttttaaagct gctgaagttt gttggtttct cattgttttt 120 aagcctactg gagcaataaa gtttgaagaa cttttaccag gtttttttta tcgctgcctt 180 gatatacact tttcaaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag 240 atgttcaaaa gaaaacattc acaaaatggg taaatgcaca attttctaag tttgggaagc 300 agcatattga gaacctcttc agtgacctac aggatgggag gcgcctccta gacctcctcg 360 aaggcctgac agggcaaaaa ctgccaaaag aaaaaggatc cacaagagtt catgccctga 420 acaatgtcaa caaggcactg cgggttttgc agaacaataa tgttgattta gtgaatattg 480 gaagtactga catcgtagat ggaaatcata aactgactct tggtttgatt tggaatataa 540 tcctccactg gcaggtcaaa aatgtaatga aaaatatcat ggctggattg caacaaacca 600 acagtgaaaa gattctcctg agctgggtcc gacaatcaac tcgtaattat ccacaggtta 660 atgtaatcaa cttcaccacc agctggtctg atggcctggc tttgaatgct ctcatccata 720 gtcataggcc agacctattt gactggaata gtgtggtttg ccagcagtca gccacacaac 780 gactggaaca tgcattcaac atcgccagat atcaattagg catagagaaa ctactcgatc 840 ctgaagatgt tgataccacc tatccagata agaagtccat cttaatgtac atcacatcac 900 tcttccaagt tttgcctcaa caagtgagca ttgaagccat ccaggaagtg gaaatgttgc 960 caaggccacc taaagtgact aaagaagaac attttcagtt acatcatcaa atgcactatt 1020 ctcaacagat cacggtcagt ctagcacagg gatatgagag aacttcttcc cctaagcctc 1080 gattcaagag ctatgcctac acacaggctg cttatgtcac cacctctgac cctacacgga 1140 gcccatttcc ttcacagcat ttggaagctc ctgaagacaa gtcatttggc agttcattga 1200 tggagagtga agtaaacctg gaccgttatc aaacagcttt agaagaagta ttatcgtggc 1260 ttctttctgc tgaggacaca ttgcaagcac aaggagagat ttctaatgat gtggaagtgg 1320 tgaaagacca gtttcatact catgaggggt acatgatgga tttgacagcc catcagggcc 1380 gggttggtaa tattctacaa ttgggaagta agctgattgg aacaggaaaa ttatcagaag 1440 atgaagaaac tgaagtacaa gagcagatga atctcctaaa ttcaagatgg gaatgcctca 1500 gggtagctag catggaaaaa caaagcaatt tacatagagt tttaatggat ctccagaatc 1560 agaaactgaa agagttgaat gactggctaa caaaaacaga agaaagaaca aggaaaatgg 1620 aggaagagcc tcttggacct gatcttgaag acctaaaacg ccaagtacaa caacataagg 1680 tgcttcaaga agatctagaa caagaacaag tcagggtcaa ttctctcact cacatggtgg 1740 tggtagttga tgaatctagt ggagatcacg caactgctgc tttggaagaa caacttaagg 1800 tattgggaga tcgatgggca aacatctgta gatggacaga agaccgctgg gttcttttac 1860 aagacatcct tctcaaatgg caacgtctta ctgaagaaca gtgccttttt agtgcatggc 1920 tttcagaaaa agaagatgca gtgaacaaga ttcacacaac tggctttaaa gatcaaaatg 1980 aaatgttatc aagtcttcaa aaactggccg ttttaaaagc ggatctagaa aagaaaaagc 2040 aatccatggg caaactgtat tcactcaaac aagatcttct ttcaacactg aagaataagt 2100 cagtgaccca gaagacggaa gcatggctgg ataactttgc ccggtgttgg gataatttag 2160 tccaaaaact tgaaaagagt acagcacaga tttcacaggc tgtcaccacc actcagccat 2220 cactaacaca gacaactgta atggaaacag taactacggt gaccacaagg gaacagatcc 2280 tggtaaagca tgctcaagag gaacttccac caccacctcc ccaaaagaag aggcagatta 2340 ctgtggattc tgaaattagg aaaaggttgg atgttgatat aactgaactt cacagctgga 2400 ttactcgctc agaagctgtg ttgcagagtc ctgaatttgc aatctttcgg aaggaaggca 2460 acttctcaga cttaaaagaa aaagtcaatg ccatagagcg agaaaaagct gagaagttca 2520 gaaaactgca agatgccagc agatcagctc aggccctggt ggaacagatg gtgaatgagg 2580 gtgttaatgc agatagcatc aaacaagcct cagaacaact gaacagccgg tggatcgaat 2640 tctgccagtt gctaagtgag agacttaact ggctggagta tcagaacaac atcatcgctt 2700 tctataatca gctacaacaa ttggagcaga tgacaactac tgctgaaaac tggttgaaaa 2760 tccaacccac caccccatca gagccaacag caattaaaag tcagttaaaa atttgtaagg 2820 atgaagtcaa ccggctatca gatcttcaac ctcaaattga acgattaaaa attcaaagca 2880 tagccctgaa agagaaagga caaggaccca tgttcctgga tgcagacttt gtggccttta 2940 caaatcattt taagcaagtc ttttctgatg tgcaggccag agagaaagag ctacagacaa 3000 tttttgacac tttgccacca atgcgctatc aggagaccat gagtgccatc aggacatggg 3060 tccagcagtc agaaaccaaa ctctccatac ctcaacttag tgtcaccgac tatgaaatca 3120 tggagcagag actcggggaa ttgcaggctt tacaaagttc tctgcaagag caacaaagtg 3180 gcctatacta tctcagcacc actgtgaaag agatgtcgaa gaaagcgccc tctgaaatta 3240 gccggaaata tcaatcagaa tttgaagaaa ttgagggacg ctggaagaag ctctcctccc 3300 agctggttga gcattgtcaa aagctagagg agcaaatgaa taaactccga aaaattcaga 3360 atcacataca aaccctgaag aaatggatgg ctgaagttga tgtttttctg aaggaggaat 3420 ggcctgccct tggggattca gaaattctaa aaaagcagct gaaacagtgc agacttttag 3480 tcagtgatat tcagacaatt cagcccagtc taaacagtgt caatgaaggt gggcagaaga 3540 taaagaatga agcagagcca gagtttgctt cgagacttga gacagaactc aaagaactta 3600 acactcagtg ggatcacatg tgccaacagg tctatgccag aaaggaggcc ttgaagggag 3660 gtttggagaa aactgtaagc ctccagaaag atctatcaga gatgcacgaa tggatgacac 3720 aagctgaaga agagtatctt gagagagatt ttgaatataa aactccagat gaattacaga 3780 aagcagttga agagatgaag agagctaaag aagaggccca acaaaaagaa gcgaaagtga 3840 aactccttac tgagtctgta aatagtgtca tagctcaagc tccacctgta gcacaagagg 3900 ccttaaaaaa ggaacttgaa actctaacca ccaactacca gtggctctgc actaggctga 3960 atgggaaatg caagactttg gaagaagttt gggcatgttg gcatgagtta ttgtcatact 4020 tggagaaagc aaacaagtgg ctaaatgaag tagaatttaa acttaaaacc actgaaaaca 4080 ttcctggcgg agctgaggaa atctctgagg tgctagattc acttgaaaat ttgatgcgac 4140 attcagagga taacccaaat cagattcgca tattggcaca gaccctaaca gatggcggag 4200 tcatggatga gctaatcaat gaggaacttg agacatttaa ttctcgttgg agggaactac 4260 atgaagaggc tgtaaggagg caaaagttgc ttgaacagag catccagtct gcccaggaga 4320 ctgaaaaatc cttacactta atccaggagt ccctcacatt cattgacaag cagttggcag 4380 cttatattgc agacaaggtg gacgcagctc aaatgcctca ggaagcccag aaaatccaat 4440 ctgatttgac aagtcatgag atcagtttag aagaaatgaa gaaacataat caggggaagg 4500 aggctgccca aagagtcctg tctcagattg atgttgcaca gaaaaaatta caagatgtct 4560 ccatgaagtt tcgattattc cagaaaccag ccaattttga gcagcgtcta caagaaagta 4620 agatgatttt agatgaagtg aagatgcact tgcctgcatt ggaaacaaag agtgtggaac 4680 aggaagtagt acagtcacag ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag 4740 tgaagtctga agtggaaatg gtgataaaga ctggacgtca gattgtacag aaaaagcaga 4800 cggaaaatcc caaagaactt gatgaaagag taacagcttt gaaattgcat tataatgagc 4860 tgggagcaaa ggtaacagaa agaaagcaac agttggagaa atgcttgaaa ttgtcccgta 4920 agatgcgaaa ggaaatgaat gtcttgacag aatggctggc agctacagat atggaattga 4980 caaagagatc agcagttgaa ggaatgccta gtaatttgga ttctgaagtt gcctggggaa 5040 aggctactca aaaagagatt gagaaacaga aggtgcacct gaagagtatc acagaggtag 5100 gagaggcctt gaaaacagtt ttgggcaaga aggagacgtt ggtggaagat aaactcagtc 5160 ttctgaatag taactggata gctgtcacct cccgagcaga agagtggtta aatcttttgt 5220 tggaatacca gaaacacatg gaaacttttg accagaatgt ggaccacatc acaaagtgga 5280 tcattcaggc tgacacactt ttggatgaat cagagaaaaa gaaaccccag caaaaagaag 5340 acgtgcttaa gcgtttaaag gcagaactga atgacatacg cccaaaggtg gactctacac 5400 gtgaccaagc agcaaacttg atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc 5460 cccaaatctc agagctcaac catcgatttg cagccatttc acacagaatt aagactggaa 5520 aggcctccat tcctttgaag gaattggagc agtttaactc agatatacaa aaattgcttg 5580 aaccactgga ggctgaaatt cagcaggggg tgaatctgaa agaggaagac ttcaataaag 5640 atatgaatga agacaatgag ggtactgtaa aagaattgtt gcaaagagga gacaacttac 5700 aacaaagaat cacagatgag agaaagcgag aggaaataaa gataaaacag cagctgttac 5760 agacaaaaca taatgctctc aaggatttga ggtctcaaag aagaaaaaag gctctagaaa 5820 tttctcatca gtggtatcag tacaagaggc aggctgatga tctcctgaaa tgcttggatg 5880 acattgaaaa aaaattagcc agcctacctg agcccagaga tgaaaggaaa ataaaggaaa 5940 ttgatcggga attgcagaag aagaaagagg agctgaatgc agtgcgtagg caagctgagg 6000 gcttgtctga ggatggggcc gcaatggcag tggagccaac tcagatccag ctcagcaagc 6060 gctggcggga aattgagagc aaatttgctc agtttcgaag actcaacttt gcacaaattc 6120 acactgtccg tgaagaaacg atgatggtga tgactgaaga catgcctttg gaaatttctt 6180 atgtgccttc tacttatttg actgaaatca ctcatgtctc acaagcccta ttagaagtgg 6240 aacaacttct caatgctcct gacctctgtg ctaaggactt tgaagatctc tttaagcaag 6300 aggagtctct gaagaatata aaagatagtc tacaacaaag ctcaggtcgg attgacatta 6360 ttcatagcaa gaagacagca gcattgcaaa gtgcaacgcc tgtggaaagg gtgaagctac 6420 aggaagctct ctcccagctt gatttccaat gggaaaaagt taacaaaatg tacaaggacc 6480 gacaagggcg atttgacaga tctgttgaga aatggcggcg ttttcattat gatataaaga 6540 tatttaatca gtggctaaca gaagctgaac agtttctcag aaagacacaa attcctgaga 6600 attgggaaca tgctaaatac aaatggtatc ttaaggaact ccaggatggc attgggcagc 6660 ggcaaactgt tgtcagaaca ttgaatgcaa ctggggaaga aataattcag caatcctcaa 6720 aaacagatgc cagtattcta caggaaaaat tgggaagcct gaatctgcgg tggcaggagg 6780 tctgcaaaca gctgtcagac agaaaaaaga ggctagaaga acaaaagaat atcttgtcag 6840 aatttcaaag agatttaaat gaatttgttt tatggttgga ggaagcagat aacattgcta 6900 gtatcccact tgaacctgga aaagagcagc aactaaaaga aaagcttgag caagtcaagt 6960 tactggtgga agagttgccc ctgcgccagg gaattctcaa acaattaaat gaaactggag 7020 gacccgtgct tgtaagtgct cccataagcc cagaagagca agataaactt gaaaataagc 7080 tcaagcagac aaatctccag tggataaagg tttccagagc tttacctgag aaacaaggag 7140 aaattgaagc tcaaataaaa gaccttgggc agcttgaaaa aaagcttgaa gaccttgaag 7200 agcagttaaa tcatctgctg ctgtggttat ctcctattag gaatcagttg gaaatttata 7260 accaaccaaa ccaagaagga ccatttgacg ttaaggaaac tgaaatagca gttcaagcta 7320 aacaaccgga tgtggaagag attttgtcta aagggcagca tttgtacaag gaaaaaccag 7380 ccactcagcc agtgaagagg aagttagaag atctgagctc tgagtggaag gcggtaaacc 7440 gtttacttca agagctgagg gcaaagcagc ctgacctagc tcctggactg accactattg 7500 gagcctctcc tactcagact gttactctgg tgacacaacc tgtggttact aaggaaactg 7560 ccatctccaa actagaaatg ccatcttcct tgatgttgga ggtacctgct ctggcagatt 7620 tcaaccgggc ttggacagaa cttaccgact ggctttctct gcttgatcaa gttataaaat 7680 cacagagggt gatggtgggt gaccttgagg atatcaacga gatgatcatc aagcagaagg 7740 caacaatgca ggatttggaa cagaggcgtc cccagttgga agaactcatt accgctgccc 7800 aaaatttgaa aaacaagacc agcaatcaag aggctagaac aatcattacg gatcgaattg 7860 aaagaattca gaatcagtgg gatgaagtac aagaacacct tcagaaccgg aggcaacagt 7920 tgaatgaaat gttaaaggat tcaacacaat ggctggaagc taaggaagaa gctgagcagg 7980 tcttaggaca ggccagagcc aagcttgagt catggaagga gggtccctat acagtagatg 8040 caatccaaaa gaaaatcaca gaaaccaagc agttggccaa agacctccgc cagtggcaga 8100 caaatgtaga tgtggcaaat gacttggccc tgaaacttct ccgggattat tctgcagatg 8160 ataccagaaa agtccacatg ataacagaga atatcaatgc ctcttggaga agcattcata 8220 aaagggtgag tgagcgagag gctgctttgg aagaaactca tagattactg caacagttcc 8280 ccctggacct ggaaaagttt cttgcctggc ttacagaagc tgaaacaact gccaatgtcc 8340 tacaggatgc tacccgtaag gaaaggctcc tagaagactc caagggagta aaagagctga 8400 tgaaacaatg gcaagacctc caaggtgaaa ttgaagctca cacagatgtt tatcacaacc 8460 tggatgaaaa cagccaaaaa atcctgagat ccctggaagg ttccgatgat gcagtcctgt 8520 tacaaagacg tttggataac atgaacttca agtggagtga acttcggaaa aagtctctca 8580 acattaggtc ccatttggaa gccagttctg accagtggaa gcgtctgcac ctttctctgc 8640 aggaacttct ggtgtggcta cagctgaaag atgatgaatt aagccggcag gcacctattg 8700 gaggcgactt tccagcagtt cagaagcaga acgatgtaca tagggccttc aagagggaat 8760 tgaaaactaa agaacctgta atcatgagta ctcttgagac tgtacgaata tttctgacag 8820 agcagccttt ggaaggacta gagaaactct accaggagcc cagagagctg cctcctgagg 8880 agagagccca gaatgtcact cggcttctac gaaagcaggc tgaggaggtc aatactgagt 8940 gggaaaaatt gaacctgcac tccgctgact ggcagagaaa aatagatgag acccttgaaa 9000 gactccggga acttcaagag gccacggatg agctggacct caagctgcgc caagctgagg 9060 tgatcaaggg atcctggcag cccgtgggcg atctcctcat tgactctctc caagatcacc 9120 tcgagaaagt caaggcactt cgaggagaaa ttgcgcctct gaaagagaac gtgagccacg 9180 tcaatgacct tgctcgccag cttaccactt tgggcattca gctctcaccg tataacctca 9240 gcactctgga agacctgaac accagatgga agcttctgca ggtggccgtc gaggaccgag 9300 tcaggcagct gcatgaagcc cacagggact ttggtccagc atctcagcac tttctttcca 9360 cgtctgtcca gggtccctgg gagagagcca tctcgccaaa caaagtgccc tactatatca 9420 accacgagac tcaaacaact tgctgggacc atcccaaaat gacagagctc taccagtctt 9480 tagctgacct gaataatgtc agattctcag cttataggac tgccatgaaa ctccgaagac 9540 tgcagaaggc cctttgcttg gatctcttga gcctgtcagc tgcatgtgat gccttggacc 9600 agcacaacct caagcaaaat gaccagccca tggatatcct gcagattatt aattgtttga 9660 ccactattta tgaccgcctg gagcaagagc acaacaattt ggtcaacgtc cctctctgcg 9720 tggatatgtg tctgaactgg ctgctgaatg tttatgatac gggacgaaca gggaggatcc 9780 gtgtcctgtc ttttaaaact ggcatcattt ccctgtgtaa agcacatttg gaagacaagt 9840 acagatacct tttcaagcaa gtggcaagtt caacaggatt ttgtgaccag cgcaggctgg 9900 gcctccttct gcatgattct atccaaattc caagacagtt gggtgaagtt gcatcctttg 9960 ggggcagtaa cattgagcca agtgtccgga gctgcttcca atttgctaat aataagccag 10020 agatcgaagc ggccctcttc ctagactgga tgagactgga accccagtcc atggtgtggc 10080 tgcccgtcct gcacagagtg gctgctgcag aaactgccaa gcatcaggcc aaatgtaaca 10140 tctgcaaaga gtgtccaatc attggattca ggtacaggag tctaaagcac tttaattatg 10200 acatctgcca aagctgcttt ttttctggtc gagttgcaaa aggccataaa atgcactatc 10260 ccatggtgga atattgcact ccgactacat caggagaaga tgttcgagac tttgccaagg 10320 tactaaaaaa caaatttcga accaaaaggt attttgcgaa gcatccccga atgggctacc 10380 tgccagtgca gactgtctta gagggggaca acatggaaac gaatctgcaa gcagaatatg 10440 accgtctaaa gcagcagcac gaacataaag gcctgtcccc actgccgtcc cctcctgaaa 10500 tgatgcccac ctctccccag agtccccggg atgctgagct cattgctgag gccaagctac 10560 tgcgtcaaca caaaggccgc ctggaagcca ggatgcaaat cctggaagac cacaataaac 10620 agctggagtc acagttacac aggctaaggc agctgctgga gcaaccccag gcagaggcca 10680 aagtgaatgg cacaacggtg tcctctcctt ctacctctct acagaggtcc gacagcagtc 10740 agcctatgct gctccgagtg gttggcagtc aaacttcgga ctccatgggt gaggaagatc 10800 ttctcagtcc tccccaggac acaagcacag ggttagagga ggtgatggag caactcaaca 10860 actccttccc tagttcaaga ggaagaaata cccctggaaa gccaatgaga gaggacacaa 10920 tgtaggaagt cttttccaca tggcagatga tttgggcaga gcgatggagt ccttagtatc 10980 agtcatgaca gatgaagaag gagcagaata aatgttttac aactcctgat tcccgcatgg 11040 tttttataat attcatacaa caaagaggat tagacagtaa gagtttacaa gaaataaatc 11100 tatatttttg tgaagggtag tggtattata ctgtagattt cagtagtttc taagtctgtt 11160 attgttttgt taacaatggc aggttttaca cgtctatgca attgtacaaa aaagttataa 11220 gaaaactaca tgtaaaatct tgatagctaa ataacttgcc atttctttat atggaacgca 11280 ttttgggttg tttaaaaatt tataacagtt ataaagaaag attgtaaact aaagtgtgct 11340 ttataaaaaa aagttgttta taaaaacccc taaaaacaaa acaaacacac acacacacac 11400 atacacacac acacacaaaa ctttgaggca gcgcattgtt ttgcatcctt ttggcgtgat 11460 atccatatga aattcatggc tttttctttt tttgcatatt aaagataaga cttcctctac 11520 caccacacca aatgactact acacactgct catttgagaa ctgtcagctg agtggggcag 11580 gcttgagttt tcatttcata tatctatatg tctataagta tataaatact atagttatat 11640 agataaagag atacgaattt ctatagactg actttttcca ttttttaaat gttcatgtca 11700 catcctaata gaaagaaatt acttctagtc agtcatccag gcttacctgc ttggtctaga 11760 atggattttt cccggagccg gaagccagga ggaaactaca ccacactaaa acattgtcta 11820 cagctccaga tgtttctcat tttaaacaac tttccactga caacgaaagt aaagtaaagt 11880 attggatttt tttaaaggga acatgtgaat gaatacacag gacttattat atcagagtga 11940 gtaatcggtt ggttggttga ttgattgatt gattgataca ttcagcttcc tgctgctagc 12000 aatgccacga tttagattta atgatgcttc agtggaaatc aatcagaagg tattctgacc 12060 ttgtgaacat cagaaggtat tttttaactc ccaagcagta gcaggacgat gatagggctg 12120 gagggctatg gattcccagc ccatccctgt gaaggagtag gccactcttt aagtgaagga 12180 ttggatgatt gttcataata cataaagttc tctgtaatta caactaaatt attatgccct 12240 cttctcacag tcaaaaggaa ctgggtggtt tggtttttgt tgctttttta gatttattgt 12300 cccatgtggg atgagttttt aaatgccaca agacataatt taaaataaat aaactttggg 12360 aaaaggtgta aaacagtagc cccatcacat ttgtgatact gacaggtatc aacccagaag 12420 cccatgaact gtgtttccat cctttgcatt tctctgcgag tagttccaca caggtttgta 12480 agtaagtaag aaagaaggca aattgattca aatgttacaa aaaaaccctt cttggtggat 12540 tagacaggtt aaatatataa acaaacaaac aaaaattgct caaaaaagag gagaaaagct 12600 caagaggaaa agctaaggac tggtaggaaa aagctttact ctttcatgcc attttatttc 12660 tttttgattt ttaaatcatt cattcaatag ataccaccgt gtgacctata attttgcaaa 12720 tctgttacct ctgacatcaa gtgtaattag cttttggaga gtgggctgac atcaagtgta 12780 attagctttt ggagagtggg ttttgtccat tattaataat taattaatta acatcaaaca 12840 cggcttctca tgctatttct acctcacttt ggttttgggg tgttcctgat aattgtgcac 12900 acctgagttc acagcttcac cacttgtcca ttgcgttatt ttctttttcc tttataattc 12960 tttctttttc cttcataatt ttcaaaagaa aacccaaagc tctaaggtaa caaattacca 13020 aattacatga agatttggtt tttgtcttgc atttttttcc tttatgtgac gctggacctt 13080 ttctttaccc aaggattttt aaaactcaga tttaaaacaa ggggttactt tacatcctac 13140 taagaagttt aagtaagtaa gtttcattct aaaatcagag gtaaatagag tgcataaata 13200 attttgtttt aatctttttg tttttctttt agacacatta gctctggagt gagtctgtca 13260 taatatttga acaaaaattg agagctttat tgctgcattt taagcataat taatttggac 13320 attatttcgt gttgtgttct ttataaccac caagtattaa actgtaaatc ataatgtaac 13380 tgaagcataa acatcacatg gcatgttttg tcattgtttt caggtactga gttcttactt 13440 gagtatcata atatattgtg ttttaacacc aacactgtaa catttacgaa ttattttttt 13500 aaacttcagt tttactgcat tttcacaaca tatcagactt caccaaatat atgccttact 13560 attgtattat agtactgctt tactgtgtat ctcaataaag cacgcagtta tgttacaaaa 13620 aagta 13625 <210> 45 <211> 3575 <212> PRT <213> Homo sapiens <400> 45 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser 1775 1780 1785 Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln 1790 1795 1800 Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu 1805 1810 1815 Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn 1820 1825 1830 Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys 1835 1840 1845 Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp 1850 1855 1860 Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln 1865 1870 1875 Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu 1880 1885 1890 Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp 1895 1900 1905 Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys 1910 1915 1920 Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu 1925 1930 1935 Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser 1940 1945 1950 Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg 1955 1960 1965 Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met 1970 1975 1980 Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser 1985 1990 1995 Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu 2000 2005 2010 Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe 2015 2020 2025 Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp 2030 2035 2040 Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys 2045 2050 2055 Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 2060 2065 2070 Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 2075 2080 2085 Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 2090 2095 2100 Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 2105 2110 2115 Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro 2120 2125 2130 Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu 2135 2140 2145 Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 2150 2155 2160 Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala 2165 2170 2175 Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln 2180 2185 2190 Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu 2195 2200 2205 Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe 2210 2215 2220 Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu 2225 2230 2235 Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val 2240 2245 2250 Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys 2255 2260 2265 Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile 2270 2275 2280 Ser Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr 2285 2290 2295 Asn Leu Gln Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln 2300 2305 2310 Gly Glu Ile Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys 2315 2320 2325 Lys Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp 2330 2335 2340 Leu Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn 2345 2350 2355 Gln Glu Gly Pro Phe Asp Val Lys Glu Thr Glu Ile Ala Val Gln 2360 2365 2370 Ala Lys Gln Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His 2375 2380 2385 Leu Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu 2390 2395 2400 Glu Asp Leu Ser Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln 2405 2410 2415 Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr 2420 2425 2430 Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro 2435 2440 2445 Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser 2450 2455 2460 Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala 2465 2470 2475 Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile 2480 2485 2490 Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 2495 2500 2505 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg 2510 2515 2520 Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys 2525 2530 2535 Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg 2540 2545 2550 Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu 2555 2560 2565 Gln Asn Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr 2570 2575 2580 Gln Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln 2585 2590 2595 Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val 2600 2605 2610 Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys 2615 2620 2625 Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu 2630 2635 2640 Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys 2645 2650 2655 Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile 2660 2665 2670 His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His 2675 2680 2685 Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala 2690 2695 2700 Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala 2705 2710 2715 Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu 2720 2725 2730 Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 2735 2740 2745 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu 2750 2755 2760 Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg 2765 2770 2775 Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser 2780 2785 2790 Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys 2795 2800 2805 Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu 2810 2815 2820 Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe 2825 2830 2835 Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg 2840 2845 2850 Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr 2855 2860 2865 Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 2870 2875 2880 Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln 2885 2890 2895 Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr 2900 2905 2910 Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys 2915 2920 2925 Ile Asp Glu Thr Leu Glu Arg Leu Arg Glu Leu Gln Glu Ala Thr 2930 2935 2940 Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly 2945 2950 2955 Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp 2960 2965 2970 His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 2975 2980 2985 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 2990 2995 3000 Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 3005 3010 3015 Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 3020 3025 3030 Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala 3035 3040 3045 Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg 3050 3055 3060 Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 3065 3070 3075 Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln 3080 3085 3090 Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr 3095 3100 3105 Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu 3110 3115 3120 Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu 3125 3130 3135 Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys 3140 3145 3150 Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu 3155 3160 3165 Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu 3170 3175 3180 Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser 3185 3190 3195 Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp 3200 3205 3210 Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 3215 3220 3225 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln 3230 3235 3240 Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn 3245 3250 3255 Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys 3260 3265 3270 Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu 3275 3280 3285 Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala 3290 3295 3300 Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu 3305 3310 3315 Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn 3320 3325 3330 Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys 3335 3340 3345 Gly His Lys Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr 3350 3355 3360 Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn 3365 3370 3375 Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly 3380 3385 3390 Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr 3395 3400 3405 Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His 3410 3415 3420 Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr 3425 3430 3435 Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys 3440 3445 3450 Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile 3455 3460 3465 Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu 3470 3475 3480 Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly 3485 3490 3495 Thr Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser 3500 3505 3510 Ser Gln Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp 3515 3520 3525 Ser Met Gly Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser 3530 3535 3540 Thr Gly Leu Glu Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro 3545 3550 3555 Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys Pro Met Arg Glu Asp 3560 3565 3570 Thr Met 3575 <210> 46 <211> 13916 <212> DNA <213> Homo sapiens <400> 46 actttccccc tacaggactc agatctggga ggcaattacc ttcggagaaa aacgaatagg 60 aaaaactgaa gtgttacttt ttttaaagct gctgaagttt gttggtttct cattgttttt 120 aagcctactg gagcaataaa gtttgaagaa cttttaccag gtttttttta tcgctgcctt 180 gatatacact tttcaaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag 240 atgttcaaaa gaaaacattc acaaaatggg taaatgcaca attttctaag tttgggaagc 300 agcatattga gaacctcttc agtgacctac aggatgggag gcgcctccta gacctcctcg 360 aaggcctgac agggcaaaaa ctgccaaaag aaaaaggatc cacaagagtt catgccctga 420 acaatgtcaa caaggcactg cgggttttgc agaacaataa tgttgattta gtgaatattg 480 gaagtactga catcgtagat ggaaatcata aactgactct tggtttgatt tggaatataa 540 tcctccactg gcaggtcaaa aatgtaatga aaaatatcat ggctggattg caacaaacca 600 acagtgaaaa gattctcctg agctgggtcc gacaatcaac tcgtaattat ccacaggtta 660 atgtaatcaa cttcaccacc agctggtctg atggcctggc tttgaatgct ctcatccata 720 gtcataggcc agacctattt gactggaata gtgtggtttg ccagcagtca gccacacaac 780 gactggaaca tgcattcaac atcgccagat atcaattagg catagagaaa ctactcgatc 840 ctgaagatgt tgataccacc tatccagata agaagtccat cttaatgtac atcacatcac 900 tcttccaagt tttgcctcaa caagtgagca ttgaagccat ccaggaagtg gaaatgttgc 960 caaggccacc taaagtgact aaagaagaac attttcagtt acatcatcaa atgcactatt 1020 ctcaacagat cacggtcagt ctagcacagg gatatgagag aacttcttcc cctaagcctc 1080 gattcaagag ctatgcctac acacaggctg cttatgtcac cacctctgac cctacacgga 1140 gcccatttcc ttcacagcat ttggaagctc ctgaagacaa gtcatttggc agttcattga 1200 tggagagtga agtaaacctg gaccgttatc aaacagcttt agaagaagta ttatcgtggc 1260 ttctttctgc tgaggacaca ttgcaagcac aaggagagat ttctaatgat gtggaagtgg 1320 tgaaagacca gtttcatact catgaggggt acatgatgga tttgacagcc catcagggcc 1380 gggttggtaa tattctacaa ttgggaagta agctgattgg aacaggaaaa ttatcagaag 1440 atgaagaaac tgaagtacaa gagcagatga atctcctaaa ttcaagatgg gaatgcctca 1500 gggtagctag catggaaaaa caaagcaatt tacatagagt tttaatggat ctccagaatc 1560 agaaactgaa agagttgaat gactggctaa caaaaacaga agaaagaaca aggaaaatgg 1620 aggaagagcc tcttggacct gatcttgaag acctaaaacg ccaagtacaa caacataagg 1680 tgcttcaaga agatctagaa caagaacaag tcagggtcaa ttctctcact cacatggtgg 1740 tggtagttga tgaatctagt ggagatcacg caactgctgc tttggaagaa caacttaagg 1800 tattgggaga tcgatgggca aacatctgta gatggacaga agaccgctgg gttcttttac 1860 aagacatcct tctcaaatgg caacgtctta ctgaagaaca gtgccttttt agtgcatggc 1920 tttcagaaaa agaagatgca gtgaacaaga ttcacacaac tggctttaaa gatcaaaatg 1980 aaatgttatc aagtcttcaa aaactggccg ttttaaaagc ggatctagaa aagaaaaagc 2040 aatccatggg caaactgtat tcactcaaac aagatcttct ttcaacactg aagaataagt 2100 cagtgaccca gaagacggaa gcatggctgg ataactttgc ccggtgttgg gataatttag 2160 tccaaaaact tgaaaagagt acagcacaga tttcacaggc tgtcaccacc actcagccat 2220 cactaacaca gacaactgta atggaaacag taactacggt gaccacaagg gaacagatcc 2280 tggtaaagca tgctcaagag gaacttccac caccacctcc ccaaaagaag aggcagatta 2340 ctgtggattc tgaaattagg aaaaggttgg atgttgatat aactgaactt cacagctgga 2400 ttactcgctc agaagctgtg ttgcagagtc ctgaatttgc aatctttcgg aaggaaggca 2460 acttctcaga cttaaaagaa aaagtcaatg ccatagagcg agaaaaagct gagaagttca 2520 gaaaactgca agatgccagc agatcagctc aggccctggt ggaacagatg gtgaatgagg 2580 gtgttaatgc agatagcatc aaacaagcct cagaacaact gaacagccgg tggatcgaat 2640 tctgccagtt gctaagtgag agacttaact ggctggagta tcagaacaac atcatcgctt 2700 tctataatca gctacaacaa ttggagcaga tgacaactac tgctgaaaac tggttgaaaa 2760 tccaacccac caccccatca gagccaacag caattaaaag tcagttaaaa atttgtaagg 2820 atgaagtcaa ccggctatca gatcttcaac ctcaaattga acgattaaaa attcaaagca 2880 tagccctgaa agagaaagga caaggaccca tgttcctgga tgcagacttt gtggccttta 2940 caaatcattt taagcaagtc ttttctgatg tgcaggccag agagaaagag ctacagacaa 3000 tttttgacac tttgccacca atgcgctatc aggagaccat gagtgccatc aggacatggg 3060 tccagcagtc agaaaccaaa ctctccatac ctcaacttag tgtcaccgac tatgaaatca 3120 tggagcagag actcggggaa ttgcaggctt tacaaagttc tctgcaagag caacaaagtg 3180 gcctatacta tctcagcacc actgtgaaag agatgtcgaa gaaagcgccc tctgaaatta 3240 gccggaaata tcaatcagaa tttgaagaaa ttgagggacg ctggaagaag ctctcctccc 3300 agctggttga gcattgtcaa aagctagagg agcaaatgaa taaactccga aaaattcaga 3360 atcacataca aaccctgaag aaatggatgg ctgaagttga tgtttttctg aaggaggaat 3420 ggcctgccct tggggattca gaaattctaa aaaagcagct gaaacagtgc agacttttag 3480 tcagtgatat tcagacaatt cagcccagtc taaacagtgt caatgaaggt gggcagaaga 3540 taaagaatga agcagagcca gagtttgctt cgagacttga gacagaactc aaagaactta 3600 acactcagtg ggatcacatg tgccaacagg tctatgccag aaaggaggcc ttgaagggag 3660 gtttggagaa aactgtaagc ctccagaaag atctatcaga gatgcacgaa tggatgacac 3720 aagctgaaga agagtatctt gagagagatt ttgaatataa aactccagat gaattacaga 3780 aagcagttga agagatgaag agagctaaag aagaggccca acaaaaagaa gcgaaagtga 3840 aactccttac tgagtctgta aatagtgtca tagctcaagc tccacctgta gcacaagagg 3900 ccttaaaaaa ggaacttgaa actctaacca ccaactacca gtggctctgc actaggctga 3960 atgggaaatg caagactttg gaagaagttt gggcatgttg gcatgagtta ttgtcatact 4020 tggagaaagc aaacaagtgg ctaaatgaag tagaatttaa acttaaaacc actgaaaaca 4080 ttcctggcgg agctgaggaa atctctgagg tgctagattc acttgaaaat ttgatgcgac 4140 attcagagga taacccaaat cagattcgca tattggcaca gaccctaaca gatggcggag 4200 tcatggatga gctaatcaat gaggaacttg agacatttaa ttctcgttgg agggaactac 4260 atgaagaggc tgtaaggagg caaaagttgc ttgaacagag catccagtct gcccaggaga 4320 ctgaaaaatc cttacactta atccaggagt ccctcacatt cattgacaag cagttggcag 4380 cttatattgc agacaaggtg gacgcagctc aaatgcctca ggaagcccag aaaatccaat 4440 ctgatttgac aagtcatgag atcagtttag aagaaatgaa gaaacataat caggggaagg 4500 aggctgccca aagagtcctg tctcagattg atgttgcaca gaaaaaatta caagatgtct 4560 ccatgaagtt tcgattattc cagaaaccag ccaattttga gcagcgtcta caagaaagta 4620 agatgatttt agatgaagtg aagatgcact tgcctgcatt ggaaacaaag agtgtggaac 4680 aggaagtagt acagtcacag ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag 4740 tgaagtctga agtggaaatg gtgataaaga ctggacgtca gattgtacag aaaaagcaga 4800 cggaaaatcc caaagaactt gatgaaagag taacagcttt gaaattgcat tataatgagc 4860 tgggagcaaa ggtaacagaa agaaagcaac agttggagaa atgcttgaaa ttgtcccgta 4920 agatgcgaaa ggaaatgaat gtcttgacag aatggctggc agctacagat atggaattga 4980 caaagagatc agcagttgaa ggaatgccta gtaatttgga ttctgaagtt gcctggggaa 5040 aggctactca aaaagagatt gagaaacaga aggtgcacct gaagagtatc acagaggtag 5100 gagaggcctt gaaaacagtt ttgggcaaga aggagacgtt ggtggaagat aaactcagtc 5160 ttctgaatag taactggata gctgtcacct cccgagcaga agagtggtta aatcttttgt 5220 tggaatacca gaaacacatg gaaacttttg accagaatgt ggaccacatc acaaagtgga 5280 tcattcaggc tgacacactt ttggatgaat cagagaaaaa gaaaccccag caaaaagaag 5340 acgtgcttaa gcgtttaaag gcagaactga atgacatacg cccaaaggtg gactctacac 5400 gtgaccaagc agcaaacttg atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc 5460 cccaaatctc agagctcaac catcgatttg cagccatttc acacagaatt aagactggaa 5520 aggcctccat tcctttgaag gaattggagc agtttaactc agatatacaa aaattgcttg 5580 aaccactgga ggctgaaatt cagcaggggg tgaatctgaa agaggaagac ttcaataaag 5640 atatgaatga agacaatgag ggtactgtaa aagaattgtt gcaaagagga gacaacttac 5700 aacaaagaat cacagatgag agaaagcgag aggaaataaa gataaaacag cagctgttac 5760 agacaaaaca taatgctctc aaggatttga ggtctcaaag aagaaaaaag gctctagaaa 5820 tttctcatca gtggtatcag tacaagaggc aggctgatga tctcctgaaa tgcttggatg 5880 acattgaaaa aaaattagcc agcctacctg agcccagaga tgaaaggaaa ataaaggaaa 5940 ttgatcggga attgcagaag aagaaagagg agctgaatgc agtgcgtagg caagctgagg 6000 gcttgtctga ggatggggcc gcaatggcag tggagccaac tcagatccag ctcagcaagc 6060 gctggcggga aattgagagc aaatttgctc agtttcgaag actcaacttt gcacaaattc 6120 acactgtccg tgaagaaacg atgatggtga tgactgaaga catgcctttg gaaatttctt 6180 atgtgccttc tacttatttg actgaaatca ctcatgtctc acaagcccta ttagaagtgg 6240 aacaacttct caatgctcct gacctctgtg ctaaggactt tgaagatctc tttaagcaag 6300 aggagtctct gaagaatata aaagatagtc tacaacaaag ctcaggtcgg attgacatta 6360 ttcatagcaa gaagacagca gcattgcaaa gtgcaacgcc tgtggaaagg gtgaagctac 6420 aggaagctct ctcccagctt gatttccaat gggaaaaagt taacaaaatg tacaaggacc 6480 gacaagggcg atttgacaga tctgttgaga aatggcggcg ttttcattat gatataaaga 6540 tatttaatca gtggctaaca gaagctgaac agtttctcag aaagacacaa attcctgaga 6600 attgggaaca tgctaaatac aaatggtatc ttaaggaact ccaggatggc attgggcagc 6660 ggcaaactgt tgtcagaaca ttgaatgcaa ctggggaaga aataattcag caatcctcaa 6720 aaacagatgc cagtattcta caggaaaaat tgggaagcct gaatctgcgg tggcaggagg 6780 tctgcaaaca gctgtcagac agaaaaaaga ggctagaaga acaaaagaat atcttgtcag 6840 aatttcaaag agatttaaat gaatttgttt tatggttgga ggaagcagat aacattgcta 6900 gtatcccact tgaacctgga aaagagcagc aactaaaaga aaagcttgag caagtcaagt 6960 tactggtgga agagttgccc ctgcgccagg gaattctcaa acaattaaat gaaactggag 7020 gacccgtgct tgtaagtgct cccataagcc cagaagagca agataaactt gaaaataagc 7080 tcaagcagac aaatctccag tggataaagg tttccagagc tttacctgag aaacaaggag 7140 aaattgaagc tcaaataaaa gaccttgggc agcttgaaaa aaagcttgaa gaccttgaag 7200 agcagttaaa tcatctgctg ctgtggttat ctcctattag gaatcagttg gaaatttata 7260 accaaccaaa ccaagaagga ccatttgacg ttaaggaaac tgaaatagca gttcaagcta 7320 aacaaccgga tgtggaagag attttgtcta aagggcagca tttgtacaag gaaaaaccag 7380 ccactcagcc agtgaagagg aagttagaag atctgagctc tgagtggaag gcggtaaacc 7440 gtttacttca agagctgagg gcaaagcagc ctgacctagc tcctggactg accactattg 7500 gagcctctcc tactcagact gttactctgg tgacacaacc tgtggttact aaggaaactg 7560 ccatctccaa actagaaatg ccatcttcct tgatgttgga ggtacctgct ctggcagatt 7620 tcaaccgggc ttggacagaa cttaccgact ggctttctct gcttgatcaa gttataaaat 7680 cacagagggt gatggtgggt gaccttgagg atatcaacga gatgatcatc aagcagaagg 7740 caacaatgca ggatttggaa cagaggcgtc cccagttgga agaactcatt accgctgccc 7800 aaaatttgaa aaacaagacc agcaatcaag aggctagaac aatcattacg gatcgaattg 7860 aaagaattca gaatcagtgg gatgaagtac aagaacacct tcagaaccgg aggcaacagt 7920 tgaatgaaat gttaaaggat tcaacacaat ggctggaagc taaggaagaa gctgagcagg 7980 tcttaggaca ggccagagcc aagcttgagt catggaagga gggtccctat acagtagatg 8040 caatccaaaa gaaaatcaca gaaaccaagc agttggccaa agacctccgc cagtggcaga 8100 caaatgtaga tgtggcaaat gacttggccc tgaaacttct ccgggattat tctgcagatg 8160 ataccagaaa agtccacatg ataacagaga atatcaatgc ctcttggaga agcattcata 8220 aaagggtgag tgagcgagag gctgctttgg aagaaactca tagattactg caacagttcc 8280 ccctggacct ggaaaagttt cttgcctggc ttacagaagc tgaaacaact gccaatgtcc 8340 tacaggatgc tacccgtaag gaaaggctcc tagaagactc caagggagta aaagagctga 8400 tgaaacaatg gcaagacctc caaggtgaaa ttgaagctca cacagatgtt tatcacaacc 8460 tggatgaaaa cagccaaaaa atcctgagat ccctggaagg ttccgatgat gcagtcctgt 8520 tacaaagacg tttggataac atgaacttca agtggagtga acttcggaaa aagtctctca 8580 acattaggtc ccatttggaa gccagttctg accagtggaa gcgtctgcac ctttctctgc 8640 aggaacttct ggtgtggcta cagctgaaag atgatgaatt aagccggcag gcacctattg 8700 gaggcgactt tccagcagtt cagaagcaga acgatgtaca tagggccttc aagagggaat 8760 tgaaaactaa agaacctgta atcatgagta ctcttgagac tgtacgaata tttctgacag 8820 agcagccttt ggaaggacta gagaaactct accaggagcc cagagagctg cctcctgagg 8880 agagagccca gaatgtcact cggcttctac gaaagcaggc tgaggaggtc aatactgagt 8940 gggaaaaatt gaacctgcac tccgctgact ggcagagaaa aatagatgag acccttgaaa 9000 gactccggga acttcaagag gccacggatg agctggacct caagctgcgc caagctgagg 9060 tgatcaaggg atcctggcag cccgtgggcg atctcctcat tgactctctc caagatcacc 9120 tcgagaaagt caaggcactt cgaggagaaa ttgcgcctct gaaagagaac gtgagccacg 9180 tcaatgacct tgctcgccag cttaccactt tgggcattca gctctcaccg tataacctca 9240 gcactctgga agacctgaac accagatgga agcttctgca ggtggccgtc gaggaccgag 9300 tcaggcagct gcatgaagcc cacagggact ttggtccagc atctcagcac tttctttcca 9360 cgtctgtcca gggtccctgg gagagagcca tctcgccaaa caaagtgccc tactatatca 9420 accacgagac tcaaacaact tgctgggacc atcccaaaat gacagagctc taccagtctt 9480 tagctgacct gaataatgtc agattctcag cttataggac tgccatgaaa ctccgaagac 9540 tgcagaaggc cctttgcttg gatctcttga gcctgtcagc tgcatgtgat gccttggacc 9600 agcacaacct caagcaaaat gaccagccca tggatatcct gcagattatt aattgtttga 9660 ccactattta tgaccgcctg gagcaagagc acaacaattt ggtcaacgtc cctctctgcg 9720 tggatatgtg tctgaactgg ctgctgaatg tttatgatac gggacgaaca gggaggatcc 9780 gtgtcctgtc ttttaaaact ggcatcattt ccctgtgtaa agcacatttg gaagacaagt 9840 acagatacct tttcaagcaa gtggcaagtt caacaggatt ttgtgaccag cgcaggctgg 9900 gcctccttct gcatgattct atccaaattc caagacagtt gggtgaagtt gcatcctttg 9960 ggggcagtaa cattgagcca agtgtccgga gctgcttcca atttgctaat aataagccag 10020 agatcgaagc ggccctcttc ctagactgga tgagactgga accccagtcc atggtgtggc 10080 tgcccgtcct gcacagagtg gctgctgcag aaactgccaa gcatcaggcc aaatgtaaca 10140 tctgcaaaga gtgtccaatc attggattca ggtacaggag tctaaagcac tttaattatg 10200 acatctgcca aagctgcttt ttttctggtc gagttgcaaa aggccataaa atgcactatc 10260 ccatggtgga atattgcact ccgactacat caggagaaga tgttcgagac tttgccaagg 10320 tactaaaaaa caaatttcga accaaaaggt attttgcgaa gcatccccga atgggctacc 10380 tgccagtgca gactgtctta gagggggaca acatggaaac gcctgcctcg tcccctcagc 10440 tttcacacga tgatactcat tcacgcattg aacattatgc tagcaggcta gcagaaatgg 10500 aaaacagcaa tggatcttat ctaaatgata gcatctctcc taatgagagc atagatgatg 10560 aacatttgtt aatccagcat tactgccaaa gtttgaacca ggactccccc ctgagccagc 10620 ctcgtagtcc tgcccagatc ttgatttcct tagagagtga ggaaagaggg gagctagaga 10680 gaatcctagc agatcttgag gaagaaaaca ggaatctgca agcagaatat gaccgtctaa 10740 agcagcagca cgaacataaa ggcctgtccc cactgccgtc ccctcctgaa atgatgccca 10800 cctctcccca gagtccccgg gatgctgagc tcattgctga ggccaagcta ctgcgtcaac 10860 acaaaggccg cctggaagcc aggatgcaaa tcctggaaga ccacaataaa cagctggagt 10920 cacagttaca caggctaagg cagctgctgg agcaacccca ggcagaggcc aaagtgaatg 10980 gcacaacggt gtcctctcct tctacctctc tacagaggtc cgacagcagt cagcctatgc 11040 tgctccgagt ggttggcagt caaacttcgg actccatggg tgaggaagat cttctcagtc 11100 ctccccagga cacaagcaca gggttagagg aggtgatgga gcaactcaac aactccttcc 11160 ctagttcaag aggaagaaat acccctggaa agccaatgag agaggacaca atgtaggaag 11220 tcttttccac atggcagatg atttgggcag agcgatggag tccttagtat cagtcatgac 11280 agatgaagaa ggagcagaat aaatgtttta caactcctga ttcccgcatg gtttttataa 11340 tattcataca acaaagagga ttagacagta agagtttaca agaaataaat ctatattttt 11400 gtgaagggta gtggtattat actgtagatt tcagtagttt ctaagtctgt tattgttttg 11460 ttaacaatgg caggttttac acgtctatgc aattgtacaa aaaagttata agaaaactac 11520 atgtaaaatc ttgatagcta aataacttgc catttcttta tatggaacgc attttgggtt 11580 gtttaaaaat ttataacagt tataaagaaa gattgtaaac taaagtgtgc tttataaaaa 11640 aaagttgttt ataaaaaccc ctaaaaacaa aacaaacaca cacacacaca catacacaca 11700 cacacacaaa actttgaggc agcgcattgt tttgcatcct tttggcgtga tatccatatg 11760 aaattcatgg ctttttcttt ttttgcatat taaagataag acttcctcta ccaccacacc 11820 aaatgactac tacacactgc tcatttgaga actgtcagct gagtggggca ggcttgagtt 11880 ttcatttcat atatctatat gtctataagt atataaatac tatagttata tagataaaga 11940 gatacgaatt tctatagact gactttttcc attttttaaa tgttcatgtc acatcctaat 12000 agaaagaaat tacttctagt cagtcatcca ggcttacctg cttggtctag aatggatttt 12060 tcccggagcc ggaagccagg aggaaactac accacactaa aacattgtct acagctccag 12120 atgtttctca ttttaaacaa ctttccactg acaacgaaag taaagtaaag tattggattt 12180 ttttaaaggg aacatgtgaa tgaatacaca ggacttatta tatcagagtg agtaatcggt 12240 tggttggttg attgattgat tgattgatac attcagcttc ctgctgctag caatgccacg 12300 atttagattt aatgatgctt cagtggaaat caatcagaag gtattctgac cttgtgaaca 12360 tcagaaggta ttttttaact cccaagcagt agcaggacga tgatagggct ggagggctat 12420 ggattcccag cccatccctg tgaaggagta ggccactctt taagtgaagg attggatgat 12480 tgttcataat acataaagtt ctctgtaatt acaactaaat tattatgccc tcttctcaca 12540 gtcaaaagga actgggtggt ttggtttttg ttgctttttt agatttattg tcccatgtgg 12600 gatgagtttt taaatgccac aagacataat ttaaaataaa taaactttgg gaaaaggtgt 12660 aaaacagtag ccccatcaca tttgtgatac tgacaggtat caacccagaa gcccatgaac 12720 tgtgtttcca tcctttgcat ttctctgcga gtagttccac acaggtttgt aagtaagtaa 12780 gaaagaaggc aaattgattc aaatgttaca aaaaaaccct tcttggtgga ttagacaggt 12840 taaatatata aacaaacaaa caaaaattgc tcaaaaaaga ggagaaaagc tcaagaggaa 12900 aagctaagga ctggtaggaa aaagctttac tctttcatgc cattttattt ctttttgatt 12960 tttaaatcat tcattcaata gataccaccg tgtgacctat aattttgcaa atctgttacc 13020 tctgacatca agtgtaatta gcttttggag agtgggctga catcaagtgt aattagcttt 13080 tggagagtgg gttttgtcca ttattaataa ttaattaatt aacatcaaac acggcttctc 13140 atgctatttc tacctcactt tggttttggg gtgttcctga taattgtgca cacctgagtt 13200 cacagcttca ccacttgtcc attgcgttat tttctttttc ctttataatt ctttcttttt 13260 ccttcataat tttcaaaaga aaacccaaag ctctaaggta acaaattacc aaattacatg 13320 aagatttggt ttttgtcttg catttttttc ctttatgtga cgctggacct tttctttacc 13380 caaggatttt taaaactcag atttaaaaca aggggttact ttacatccta ctaagaagtt 13440 taagtaagta agtttcattc taaaatcaga ggtaaataga gtgcataaat aattttgttt 13500 taatcttttt gtttttcttt tagacacatt agctctggag tgagtctgtc ataatatttg 13560 aacaaaaatt gagagcttta ttgctgcatt ttaagcataa ttaatttgga cattatttcg 13620 tgttgtgttc tttataacca ccaagtatta aactgtaaat cataatgtaa ctgaagcata 13680 aacatcacat ggcatgtttt gtcattgttt tcaggtactg agttcttact tgagtatcat 13740 aatatattgt gttttaacac caacactgta acatttacga attatttttt taaacttcag 13800 ttttactgca ttttcacaac atatcagact tcaccaaata tatgccttac tattgtatta 13860 tagtactgct ttactgtgta tctcaataaa gcacgcagtt atgttacaaa aaagta 13916 <210> 47 <211> 3672 <212> PRT <213> Homo sapiens <400> 47 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser 1775 1780 1785 Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln 1790 1795 1800 Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu 1805 1810 1815 Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn 1820 1825 1830 Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys 1835 1840 1845 Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp 1850 1855 1860 Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln 1865 1870 1875 Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu 1880 1885 1890 Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp 1895 1900 1905 Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys 1910 1915 1920 Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu 1925 1930 1935 Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser 1940 1945 1950 Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg 1955 1960 1965 Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met 1970 1975 1980 Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser 1985 1990 1995 Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu 2000 2005 2010 Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe 2015 2020 2025 Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp 2030 2035 2040 Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys 2045 2050 2055 Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 2060 2065 2070 Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 2075 2080 2085 Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 2090 2095 2100 Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 2105 2110 2115 Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro 2120 2125 2130 Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu 2135 2140 2145 Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 2150 2155 2160 Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala 2165 2170 2175 Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln 2180 2185 2190 Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu 2195 2200 2205 Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe 2210 2215 2220 Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu 2225 2230 2235 Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val 2240 2245 2250 Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys 2255 2260 2265 Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile 2270 2275 2280 Ser Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr 2285 2290 2295 Asn Leu Gln Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln 2300 2305 2310 Gly Glu Ile Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys 2315 2320 2325 Lys Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp 2330 2335 2340 Leu Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn 2345 2350 2355 Gln Glu Gly Pro Phe Asp Val Lys Glu Thr Glu Ile Ala Val Gln 2360 2365 2370 Ala Lys Gln Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His 2375 2380 2385 Leu Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu 2390 2395 2400 Glu Asp Leu Ser Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln 2405 2410 2415 Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr 2420 2425 2430 Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro 2435 2440 2445 Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser 2450 2455 2460 Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala 2465 2470 2475 Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile 2480 2485 2490 Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 2495 2500 2505 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg 2510 2515 2520 Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys 2525 2530 2535 Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg 2540 2545 2550 Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu 2555 2560 2565 Gln Asn Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr 2570 2575 2580 Gln Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln 2585 2590 2595 Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val 2600 2605 2610 Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys 2615 2620 2625 Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu 2630 2635 2640 Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys 2645 2650 2655 Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile 2660 2665 2670 His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His 2675 2680 2685 Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala 2690 2695 2700 Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala 2705 2710 2715 Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu 2720 2725 2730 Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 2735 2740 2745 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu 2750 2755 2760 Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg 2765 2770 2775 Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser 2780 2785 2790 Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys 2795 2800 2805 Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu 2810 2815 2820 Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe 2825 2830 2835 Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg 2840 2845 2850 Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr 2855 2860 2865 Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 2870 2875 2880 Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln 2885 2890 2895 Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr 2900 2905 2910 Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys 2915 2920 2925 Ile Asp Glu Thr Leu Glu Arg Leu Arg Glu Leu Gln Glu Ala Thr 2930 2935 2940 Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly 2945 2950 2955 Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp 2960 2965 2970 His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 2975 2980 2985 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 2990 2995 3000 Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 3005 3010 3015 Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 3020 3025 3030 Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala 3035 3040 3045 Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg 3050 3055 3060 Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 3065 3070 3075 Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln 3080 3085 3090 Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr 3095 3100 3105 Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu 3110 3115 3120 Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu 3125 3130 3135 Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys 3140 3145 3150 Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu 3155 3160 3165 Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu 3170 3175 3180 Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser 3185 3190 3195 Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp 3200 3205 3210 Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 3215 3220 3225 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln 3230 3235 3240 Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn 3245 3250 3255 Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys 3260 3265 3270 Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu 3275 3280 3285 Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala 3290 3295 3300 Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu 3305 3310 3315 Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn 3320 3325 3330 Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys 3335 3340 3345 Gly His Lys Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr 3350 3355 3360 Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn 3365 3370 3375 Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly 3380 3385 3390 Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr 3395 3400 3405 Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg 3410 3415 3420 Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn 3425 3430 3435 Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp 3440 3445 3450 Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln 3455 3460 3465 Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile 3470 3475 3480 Ser Leu Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala 3485 3490 3495 Asp Leu Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg 3500 3505 3510 Leu Lys Gln Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser 3515 3520 3525 Pro Pro Glu Met Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala 3530 3535 3540 Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg 3545 3550 3555 Leu Glu Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu 3560 3565 3570 Glu Ser Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro Gln 3575 3580 3585 Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr 3590 3595 3600 Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val 3605 3610 3615 Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu 3620 3625 3630 Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu 3635 3640 3645 Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro 3650 3655 3660 Gly Lys Pro Met Arg Glu Asp Thr Met 3665 3670 <210> 48 <211> 13923 <212> DNA <213> Homo sapiens <400> 48 actttccccc tacaggactc agatctggga ggcaattacc ttcggagaaa aacgaatagg 60 aaaaactgaa gtgttacttt ttttaaagct gctgaagttt gttggtttct cattgttttt 120 aagcctactg gagcaataaa gtttgaagaa cttttaccag gtttttttta tcgctgcctt 180 gatatacact tttcaaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag 240 atgttcaaaa gaaaacattc acaaaatggg taaatgcaca attttctaag tttgggaagc 300 agcatattga gaacctcttc agtgacctac aggatgggag gcgcctccta gacctcctcg 360 aaggcctgac agggcaaaaa ctgccaaaag aaaaaggatc cacaagagtt catgccctga 420 acaatgtcaa caaggcactg cgggttttgc agaacaataa tgttgattta gtgaatattg 480 gaagtactga catcgtagat ggaaatcata aactgactct tggtttgatt tggaatataa 540 tcctccactg gcaggtcaaa aatgtaatga aaaatatcat ggctggattg caacaaacca 600 acagtgaaaa gattctcctg agctgggtcc gacaatcaac tcgtaattat ccacaggtta 660 atgtaatcaa cttcaccacc agctggtctg atggcctggc tttgaatgct ctcatccata 720 gtcataggcc agacctattt gactggaata gtgtggtttg ccagcagtca gccacacaac 780 gactggaaca tgcattcaac atcgccagat atcaattagg catagagaaa ctactcgatc 840 ctgaagatgt tgataccacc tatccagata agaagtccat cttaatgtac atcacatcac 900 tcttccaagt tttgcctcaa caagtgagca ttgaagccat ccaggaagtg gaaatgttgc 960 caaggccacc taaagtgact aaagaagaac attttcagtt acatcatcaa atgcactatt 1020 ctcaacagat cacggtcagt ctagcacagg gatatgagag aacttcttcc cctaagcctc 1080 gattcaagag ctatgcctac acacaggctg cttatgtcac cacctctgac cctacacgga 1140 gcccatttcc ttcacagcat ttggaagctc ctgaagacaa gtcatttggc agttcattga 1200 tggagagtga agtaaacctg gaccgttatc aaacagcttt agaagaagta ttatcgtggc 1260 ttctttctgc tgaggacaca ttgcaagcac aaggagagat ttctaatgat gtggaagtgg 1320 tgaaagacca gtttcatact catgaggggt acatgatgga tttgacagcc catcagggcc 1380 gggttggtaa tattctacaa ttgggaagta agctgattgg aacaggaaaa ttatcagaag 1440 atgaagaaac tgaagtacaa gagcagatga atctcctaaa ttcaagatgg gaatgcctca 1500 gggtagctag catggaaaaa caaagcaatt tacatagagt tttaatggat ctccagaatc 1560 agaaactgaa agagttgaat gactggctaa caaaaacaga agaaagaaca aggaaaatgg 1620 aggaagagcc tcttggacct gatcttgaag acctaaaacg ccaagtacaa caacataagg 1680 tgcttcaaga agatctagaa caagaacaag tcagggtcaa ttctctcact cacatggtgg 1740 tggtagttga tgaatctagt ggagatcacg caactgctgc tttggaagaa caacttaagg 1800 tattgggaga tcgatgggca aacatctgta gatggacaga agaccgctgg gttcttttac 1860 aagacatcct tctcaaatgg caacgtctta ctgaagaaca gtgccttttt agtgcatggc 1920 tttcagaaaa agaagatgca gtgaacaaga ttcacacaac tggctttaaa gatcaaaatg 1980 aaatgttatc aagtcttcaa aaactggccg ttttaaaagc ggatctagaa aagaaaaagc 2040 aatccatggg caaactgtat tcactcaaac aagatcttct ttcaacactg aagaataagt 2100 cagtgaccca gaagacggaa gcatggctgg ataactttgc ccggtgttgg gataatttag 2160 tccaaaaact tgaaaagagt acagcacaga tttcacaggc tgtcaccacc actcagccat 2220 cactaacaca gacaactgta atggaaacag taactacggt gaccacaagg gaacagatcc 2280 tggtaaagca tgctcaagag gaacttccac caccacctcc ccaaaagaag aggcagatta 2340 ctgtggattc tgaaattagg aaaaggttgg atgttgatat aactgaactt cacagctgga 2400 ttactcgctc agaagctgtg ttgcagagtc ctgaatttgc aatctttcgg aaggaaggca 2460 acttctcaga cttaaaagaa aaagtcaatg ccatagagcg agaaaaagct gagaagttca 2520 gaaaactgca agatgccagc agatcagctc aggccctggt ggaacagatg gtgaatgagg 2580 gtgttaatgc agatagcatc aaacaagcct cagaacaact gaacagccgg tggatcgaat 2640 tctgccagtt gctaagtgag agacttaact ggctggagta tcagaacaac atcatcgctt 2700 tctataatca gctacaacaa ttggagcaga tgacaactac tgctgaaaac tggttgaaaa 2760 tccaacccac caccccatca gagccaacag caattaaaag tcagttaaaa atttgtaagg 2820 atgaagtcaa ccggctatca gatcttcaac ctcaaattga acgattaaaa attcaaagca 2880 tagccctgaa agagaaagga caaggaccca tgttcctgga tgcagacttt gtggccttta 2940 caaatcattt taagcaagtc ttttctgatg tgcaggccag agagaaagag ctacagacaa 3000 tttttgacac tttgccacca atgcgctatc aggagaccat gagtgccatc aggacatggg 3060 tccagcagtc agaaaccaaa ctctccatac ctcaacttag tgtcaccgac tatgaaatca 3120 tggagcagag actcggggaa ttgcaggctt tacaaagttc tctgcaagag caacaaagtg 3180 gcctatacta tctcagcacc actgtgaaag agatgtcgaa gaaagcgccc tctgaaatta 3240 gccggaaata tcaatcagaa tttgaagaaa ttgagggacg ctggaagaag ctctcctccc 3300 agctggttga gcattgtcaa aagctagagg agcaaatgaa taaactccga aaaattcaga 3360 atcacataca aaccctgaag aaatggatgg ctgaagttga tgtttttctg aaggaggaat 3420 ggcctgccct tggggattca gaaattctaa aaaagcagct gaaacagtgc agacttttag 3480 tcagtgatat tcagacaatt cagcccagtc taaacagtgt caatgaaggt gggcagaaga 3540 taaagaatga agcagagcca gagtttgctt cgagacttga gacagaactc aaagaactta 3600 acactcagtg ggatcacatg tgccaacagg tctatgccag aaaggaggcc ttgaagggag 3660 gtttggagaa aactgtaagc ctccagaaag atctatcaga gatgcacgaa tggatgacac 3720 aagctgaaga agagtatctt gagagagatt ttgaatataa aactccagat gaattacaga 3780 aagcagttga agagatgaag agagctaaag aagaggccca acaaaaagaa gcgaaagtga 3840 aactccttac tgagtctgta aatagtgtca tagctcaagc tccacctgta gcacaagagg 3900 ccttaaaaaa ggaacttgaa actctaacca ccaactacca gtggctctgc actaggctga 3960 atgggaaatg caagactttg gaagaagttt gggcatgttg gcatgagtta ttgtcatact 4020 tggagaaagc aaacaagtgg ctaaatgaag tagaatttaa acttaaaacc actgaaaaca 4080 ttcctggcgg agctgaggaa atctctgagg tgctagattc acttgaaaat ttgatgcgac 4140 attcagagga taacccaaat cagattcgca tattggcaca gaccctaaca gatggcggag 4200 tcatggatga gctaatcaat gaggaacttg agacatttaa ttctcgttgg agggaactac 4260 atgaagaggc tgtaaggagg caaaagttgc ttgaacagag catccagtct gcccaggaga 4320 ctgaaaaatc cttacactta atccaggagt ccctcacatt cattgacaag cagttggcag 4380 cttatattgc agacaaggtg gacgcagctc aaatgcctca ggaagcccag aaaatccaat 4440 ctgatttgac aagtcatgag atcagtttag aagaaatgaa gaaacataat caggggaagg 4500 aggctgccca aagagtcctg tctcagattg atgttgcaca gaaaaaatta caagatgtct 4560 ccatgaagtt tcgattattc cagaaaccag ccaattttga gcagcgtcta caagaaagta 4620 agatgatttt agatgaagtg aagatgcact tgcctgcatt ggaaacaaag agtgtggaac 4680 aggaagtagt acagtcacag ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag 4740 tgaagtctga agtggaaatg gtgataaaga ctggacgtca gattgtacag aaaaagcaga 4800 cggaaaatcc caaagaactt gatgaaagag taacagcttt gaaattgcat tataatgagc 4860 tgggagcaaa ggtaacagaa agaaagcaac agttggagaa atgcttgaaa ttgtcccgta 4920 agatgcgaaa ggaaatgaat gtcttgacag aatggctggc agctacagat atggaattga 4980 caaagagatc agcagttgaa ggaatgccta gtaatttgga ttctgaagtt gcctggggaa 5040 aggctactca aaaagagatt gagaaacaga aggtgcacct gaagagtatc acagaggtag 5100 gagaggcctt gaaaacagtt ttgggcaaga aggagacgtt ggtggaagat aaactcagtc 5160 ttctgaatag taactggata gctgtcacct cccgagcaga agagtggtta aatcttttgt 5220 tggaatacca gaaacacatg gaaacttttg accagaatgt ggaccacatc acaaagtgga 5280 tcattcaggc tgacacactt ttggatgaat cagagaaaaa gaaaccccag caaaaagaag 5340 acgtgcttaa gcgtttaaag gcagaactga atgacatacg cccaaaggtg gactctacac 5400 gtgaccaagc agcaaacttg atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc 5460 cccaaatctc agagctcaac catcgatttg cagccatttc acacagaatt aagactggaa 5520 aggcctccat tcctttgaag gaattggagc agtttaactc agatatacaa aaattgcttg 5580 aaccactgga ggctgaaatt cagcaggggg tgaatctgaa agaggaagac ttcaataaag 5640 atatgaatga agacaatgag ggtactgtaa aagaattgtt gcaaagagga gacaacttac 5700 aacaaagaat cacagatgag agaaagcgag aggaaataaa gataaaacag cagctgttac 5760 agacaaaaca taatgctctc aaggatttga ggtctcaaag aagaaaaaag gctctagaaa 5820 tttctcatca gtggtatcag tacaagaggc aggctgatga tctcctgaaa tgcttggatg 5880 acattgaaaa aaaattagcc agcctacctg agcccagaga tgaaaggaaa ataaaggaaa 5940 ttgatcggga attgcagaag aagaaagagg agctgaatgc agtgcgtagg caagctgagg 6000 gcttgtctga ggatggggcc gcaatggcag tggagccaac tcagatccag ctcagcaagc 6060 gctggcggga aattgagagc aaatttgctc agtttcgaag actcaacttt gcacaaattc 6120 acactgtccg tgaagaaacg atgatggtga tgactgaaga catgcctttg gaaatttctt 6180 atgtgccttc tacttatttg actgaaatca ctcatgtctc acaagcccta ttagaagtgg 6240 aacaacttct caatgctcct gacctctgtg ctaaggactt tgaagatctc tttaagcaag 6300 aggagtctct gaagaatata aaagatagtc tacaacaaag ctcaggtcgg attgacatta 6360 ttcatagcaa gaagacagca gcattgcaaa gtgcaacgcc tgtggaaagg gtgaagctac 6420 aggaagctct ctcccagctt gatttccaat gggaaaaagt taacaaaatg tacaaggacc 6480 gacaagggcg atttgacaga tctgttgaga aatggcggcg ttttcattat gatataaaga 6540 tatttaatca gtggctaaca gaagctgaac agtttctcag aaagacacaa attcctgaga 6600 attgggaaca tgctaaatac aaatggtatc ttaaggaact ccaggatggc attgggcagc 6660 ggcaaactgt tgtcagaaca ttgaatgcaa ctggggaaga aataattcag caatcctcaa 6720 aaacagatgc cagtattcta caggaaaaat tgggaagcct gaatctgcgg tggcaggagg 6780 tctgcaaaca gctgtcagac agaaaaaaga ggctagaaga acaaaagaat atcttgtcag 6840 aatttcaaag agatttaaat gaatttgttt tatggttgga ggaagcagat aacattgcta 6900 gtatcccact tgaacctgga aaagagcagc aactaaaaga aaagcttgag caagtcaagt 6960 tactggtgga agagttgccc ctgcgccagg gaattctcaa acaattaaat gaaactggag 7020 gacccgtgct tgtaagtgct cccataagcc cagaagagca agataaactt gaaaataagc 7080 tcaagcagac aaatctccag tggataaagg tttccagagc tttacctgag aaacaaggag 7140 aaattgaagc tcaaataaaa gaccttgggc agcttgaaaa aaagcttgaa gaccttgaag 7200 agcagttaaa tcatctgctg ctgtggttat ctcctattag gaatcagttg gaaatttata 7260 accaaccaaa ccaagaagga ccatttgacg ttaaggaaac tgaaatagca gttcaagcta 7320 aacaaccgga tgtggaagag attttgtcta aagggcagca tttgtacaag gaaaaaccag 7380 ccactcagcc agtgaagagg aagttagaag atctgagctc tgagtggaag gcggtaaacc 7440 gtttacttca agagctgagg gcaaagcagc ctgacctagc tcctggactg accactattg 7500 gagcctctcc tactcagact gttactctgg tgacacaacc tgtggttact aaggaaactg 7560 ccatctccaa actagaaatg ccatcttcct tgatgttgga ggtacctgct ctggcagatt 7620 tcaaccgggc ttggacagaa cttaccgact ggctttctct gcttgatcaa gttataaaat 7680 cacagagggt gatggtgggt gaccttgagg atatcaacga gatgatcatc aagcagaagg 7740 caacaatgca ggatttggaa cagaggcgtc cccagttgga agaactcatt accgctgccc 7800 aaaatttgaa aaacaagacc agcaatcaag aggctagaac aatcattacg gatcgaattg 7860 aaagaattca gaatcagtgg gatgaagtac aagaacacct tcagaaccgg aggcaacagt 7920 tgaatgaaat gttaaaggat tcaacacaat ggctggaagc taaggaagaa gctgagcagg 7980 tcttaggaca ggccagagcc aagcttgagt catggaagga gggtccctat acagtagatg 8040 caatccaaaa gaaaatcaca gaaaccaagc agttggccaa agacctccgc cagtggcaga 8100 caaatgtaga tgtggcaaat gacttggccc tgaaacttct ccgggattat tctgcagatg 8160 ataccagaaa agtccacatg ataacagaga atatcaatgc ctcttggaga agcattcata 8220 aaagggtgag tgagcgagag gctgctttgg aagaaactca tagattactg caacagttcc 8280 ccctggacct ggaaaagttt cttgcctggc ttacagaagc tgaaacaact gccaatgtcc 8340 tacaggatgc tacccgtaag gaaaggctcc tagaagactc caagggagta aaagagctga 8400 tgaaacaatg gcaagacctc caaggtgaaa ttgaagctca cacagatgtt tatcacaacc 8460 tggatgaaaa cagccaaaaa atcctgagat ccctggaagg ttccgatgat gcagtcctgt 8520 tacaaagacg tttggataac atgaacttca agtggagtga acttcggaaa aagtctctca 8580 acattaggtc ccatttggaa gccagttctg accagtggaa gcgtctgcac ctttctctgc 8640 aggaacttct ggtgtggcta cagctgaaag atgatgaatt aagccggcag gcacctattg 8700 gaggcgactt tccagcagtt cagaagcaga acgatgtaca tagggccttc aagagggaat 8760 tgaaaactaa agaacctgta atcatgagta ctcttgagac tgtacgaata tttctgacag 8820 agcagccttt ggaaggacta gagaaactct accaggagcc cagagagctg cctcctgagg 8880 agagagccca gaatgtcact cggcttctac gaaagcaggc tgaggaggtc aatactgagt 8940 gggaaaaatt gaacctgcac tccgctgact ggcagagaaa aatagatgag acccttgaaa 9000 gactccggga acttcaagag gccacggatg agctggacct caagctgcgc caagctgagg 9060 tgatcaaggg atcctggcag cccgtgggcg atctcctcat tgactctctc caagatcacc 9120 tcgagaaagt caaggcactt cgaggagaaa ttgcgcctct gaaagagaac gtgagccacg 9180 tcaatgacct tgctcgccag cttaccactt tgggcattca gctctcaccg tataacctca 9240 gcactctgga agacctgaac accagatgga agcttctgca ggtggccgtc gaggaccgag 9300 tcaggcagct gcatgaagcc cacagggact ttggtccagc atctcagcac tttctttcca 9360 cgtctgtcca gggtccctgg gagagagcca tctcgccaaa caaagtgccc tactatatca 9420 accacgagac tcaaacaact tgctgggacc atcccaaaat gacagagctc taccagtctt 9480 tagctgacct gaataatgtc agattctcag cttataggac tgccatgaaa ctccgaagac 9540 tgcagaaggc cctttgcttg gatctcttga gcctgtcagc tgcatgtgat gccttggacc 9600 agcacaacct caagcaaaat gaccagccca tggatatcct gcagattatt aattgtttga 9660 ccactattta tgaccgcctg gagcaagagc acaacaattt ggtcaacgtc cctctctgcg 9720 tggatatgtg tctgaactgg ctgctgaatg tttatgatac gggacgaaca gggaggatcc 9780 gtgtcctgtc ttttaaaact ggcatcattt ccctgtgtaa agcacatttg gaagacaagt 9840 acagatacct tttcaagcaa gtggcaagtt caacaggatt ttgtgaccag cgcaggctgg 9900 gcctccttct gcatgattct atccaaattc caagacagtt gggtgaagtt gcatcctttg 9960 ggggcagtaa cattgagcca agtgtccgga gctgcttcca atttgctaat aataagccag 10020 agatcgaagc ggccctcttc ctagactgga tgagactgga accccagtcc atggtgtggc 10080 tgcccgtcct gcacagagtg gctgctgcag aaactgccaa gcatcaggcc aaatgtaaca 10140 tctgcaaaga gtgtccaatc attggattca ggtacaggag tctaaagcac tttaattatg 10200 acatctgcca aagctgcttt ttttctggtc gagttgcaaa aggccataaa atgcactatc 10260 ccatggtgga atattgcact ccgactacat caggagaaga tgttcgagac tttgccaagg 10320 tactaaaaaa caaatttcga accaaaaggt attttgcgaa gcatccccga atgggctacc 10380 tgccagtgca gactgtctta gagggggaca acatggaaac tcccgttact ctgatcaact 10440 tctggccagt agattctgcg cctgcctcgt cccctcagct ttcacacgat gatactcatt 10500 cacgcattga acattatgct agcaggctag cagaaatgga aaacagcaat ggatcttatc 10560 taaatgatag catctctcct aatgagagca tagatgatga acatttgtta atccagcatt 10620 actgccaaag tttgaaccag gactcccccc tgagccagcc tcgtagtcct gcccagatct 10680 tgatttcctt agagagtgag gaaagagggg agctagagag aatcctagca gatcttgagg 10740 aagaaaacag gaatctgcaa gcagaatatg accgtctaaa gcagcagcac gaacataaag 10800 gcctgtcccc actgccgtcc cctcctgaaa tgatgcccac ctctccccag agtccccggg 10860 atgctgagct cattgctgag gccaagctac tgcgtcaaca caaaggccgc ctggaagcca 10920 ggatgcaaat cctggaagac cacaataaac agctggagtc acagttacac aggctaaggc 10980 agctgctgga gcaaccccag gcagaggcca aagtgaatgg cacaacggtg tcctctcctt 11040 ctacctctct acagaggtcc gacagcagtc agcctatgct gctccgagtg gttggcagtc 11100 aaacttcgga ctccatgggt gaggaagatc ttctcagtcc tccccaggac acaagcacag 11160 ggttagagga ggtgatggag caactcaaca actccttccc tagttcaaga ggacacaatg 11220 taggaagtct tttccacatg gcagatgatt tgggcagagc gatggagtcc ttagtatcag 11280 tcatgacaga tgaagaagga gcagaataaa tgttttacaa ctcctgattc ccgcatggtt 11340 tttataatat tcatacaaca aagaggatta gacagtaaga gtttacaaga aataaatcta 11400 tatttttgtg aagggtagtg gtattatact gtagatttca gtagtttcta agtctgttat 11460 tgttttgtta acaatggcag gttttacacg tctatgcaat tgtacaaaaa agttataaga 11520 aaactacatg taaaatcttg atagctaaat aacttgccat ttctttatat ggaacgcatt 11580 ttgggttgtt taaaaattta taacagttat aaagaaagat tgtaaactaa agtgtgcttt 11640 ataaaaaaaa gttgtttata aaaaccccta aaaacaaaac aaacacacac acacacacat 11700 acacacacac acacaaaact ttgaggcagc gcattgtttt gcatcctttt ggcgtgatat 11760 ccatatgaaa ttcatggctt tttctttttt tgcatattaa agataagact tcctctacca 11820 ccacaccaaa tgactactac acactgctca tttgagaact gtcagctgag tggggcaggc 11880 ttgagttttc atttcatata tctatatgtc tataagtata taaatactat agttatatag 11940 ataaagagat acgaatttct atagactgac tttttccatt ttttaaatgt tcatgtcaca 12000 tcctaataga aagaaattac ttctagtcag tcatccaggc ttacctgctt ggtctagaat 12060 ggatttttcc cggagccgga agccaggagg aaactacacc acactaaaac attgtctaca 12120 gctccagatg tttctcattt taaacaactt tccactgaca acgaaagtaa agtaaagtat 12180 tggatttttt taaagggaac atgtgaatga atacacagga cttattatat cagagtgagt 12240 aatcggttgg ttggttgatt gattgattga ttgatacatt cagcttcctg ctgctagcaa 12300 tgccacgatt tagatttaat gatgcttcag tggaaatcaa tcagaaggta ttctgacctt 12360 gtgaacatca gaaggtattt tttaactccc aagcagtagc aggacgatga tagggctgga 12420 gggctatgga ttcccagccc atccctgtga aggagtaggc cactctttaa gtgaaggatt 12480 ggatgattgt tcataataca taaagttctc tgtaattaca actaaattat tatgccctct 12540 tctcacagtc aaaaggaact gggtggtttg gtttttgttg cttttttaga tttattgtcc 12600 catgtgggat gagtttttaa atgccacaag acataattta aaataaataa actttgggaa 12660 aaggtgtaaa acagtagccc catcacattt gtgatactga caggtatcaa cccagaagcc 12720 catgaactgt gtttccatcc tttgcatttc tctgcgagta gttccacaca ggtttgtaag 12780 taagtaagaa agaaggcaaa ttgattcaaa tgttacaaaa aaacccttct tggtggatta 12840 gacaggttaa atatataaac aaacaaacaa aaattgctca aaaaagagga gaaaagctca 12900 agaggaaaag ctaaggactg gtaggaaaaa gctttactct ttcatgccat tttatttctt 12960 tttgattttt aaatcattca ttcaatagat accaccgtgt gacctataat tttgcaaatc 13020 tgttacctct gacatcaagt gtaattagct tttggagagt gggctgacat caagtgtaat 13080 tagcttttgg agagtgggtt ttgtccatta ttaataatta attaattaac atcaaacacg 13140 gcttctcatg ctatttctac ctcactttgg ttttggggtg ttcctgataa ttgtgcacac 13200 ctgagttcac agcttcacca cttgtccatt gcgttatttt ctttttcctt tataattctt 13260 tctttttcct tcataatttt caaaagaaaa cccaaagctc taaggtaaca aattaccaaa 13320 ttacatgaag atttggtttt tgtcttgcat ttttttcctt tatgtgacgc tggacctttt 13380 ctttacccaa ggatttttaa aactcagatt taaaacaagg ggttacttta catcctacta 13440 agaagtttaa gtaagtaagt ttcattctaa aatcagaggt aaatagagtg cataaataat 13500 tttgttttaa tctttttgtt tttcttttag acacattagc tctggagtga gtctgtcata 13560 atatttgaac aaaaattgag agctttattg ctgcatttta agcataatta atttggacat 13620 tatttcgtgt tgtgttcttt ataaccacca agtattaaac tgtaaatcat aatgtaactg 13680 aagcataaac atcacatggc atgttttgtc attgttttca ggtactgagt tcttacttga 13740 gtatcataat atattgtgtt ttaacaccaa cactgtaaca tttacgaatt atttttttaa 13800 acttcagttt tactgcattt tcacaacata tcagacttca ccaaatatat gccttactat 13860 tgtattatag tactgcttta ctgtgtatct caataaagca cgcagttatg ttacaaaaaa 13920 gta 13923 <210> 49 <211> 3703 <212> PRT <213> Homo sapiens <400> 49 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser 1775 1780 1785 Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln 1790 1795 1800 Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu 1805 1810 1815 Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn 1820 1825 1830 Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys 1835 1840 1845 Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp 1850 1855 1860 Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln 1865 1870 1875 Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu 1880 1885 1890 Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp 1895 1900 1905 Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys 1910 1915 1920 Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu 1925 1930 1935 Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser 1940 1945 1950 Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg 1955 1960 1965 Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met 1970 1975 1980 Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser 1985 1990 1995 Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu 2000 2005 2010 Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe 2015 2020 2025 Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp 2030 2035 2040 Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys 2045 2050 2055 Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 2060 2065 2070 Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 2075 2080 2085 Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 2090 2095 2100 Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 2105 2110 2115 Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro 2120 2125 2130 Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu 2135 2140 2145 Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 2150 2155 2160 Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala 2165 2170 2175 Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln 2180 2185 2190 Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu 2195 2200 2205 Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe 2210 2215 2220 Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu 2225 2230 2235 Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val 2240 2245 2250 Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys 2255 2260 2265 Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile 2270 2275 2280 Ser Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr 2285 2290 2295 Asn Leu Gln Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln 2300 2305 2310 Gly Glu Ile Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys 2315 2320 2325 Lys Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp 2330 2335 2340 Leu Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn 2345 2350 2355 Gln Glu Gly Pro Phe Asp Val Lys Glu Thr Glu Ile Ala Val Gln 2360 2365 2370 Ala Lys Gln Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His 2375 2380 2385 Leu Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu 2390 2395 2400 Glu Asp Leu Ser Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln 2405 2410 2415 Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr 2420 2425 2430 Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro 2435 2440 2445 Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser 2450 2455 2460 Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala 2465 2470 2475 Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile 2480 2485 2490 Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 2495 2500 2505 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg 2510 2515 2520 Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys 2525 2530 2535 Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg 2540 2545 2550 Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu 2555 2560 2565 Gln Asn Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr 2570 2575 2580 Gln Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln 2585 2590 2595 Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val 2600 2605 2610 Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys 2615 2620 2625 Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu 2630 2635 2640 Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys 2645 2650 2655 Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile 2660 2665 2670 His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His 2675 2680 2685 Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala 2690 2695 2700 Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala 2705 2710 2715 Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu 2720 2725 2730 Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 2735 2740 2745 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu 2750 2755 2760 Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg 2765 2770 2775 Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser 2780 2785 2790 Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys 2795 2800 2805 Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu 2810 2815 2820 Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe 2825 2830 2835 Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg 2840 2845 2850 Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr 2855 2860 2865 Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 2870 2875 2880 Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln 2885 2890 2895 Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr 2900 2905 2910 Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys 2915 2920 2925 Ile Asp Glu Thr Leu Glu Arg Leu Arg Glu Leu Gln Glu Ala Thr 2930 2935 2940 Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly 2945 2950 2955 Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp 2960 2965 2970 His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 2975 2980 2985 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 2990 2995 3000 Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 3005 3010 3015 Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 3020 3025 3030 Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala 3035 3040 3045 Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg 3050 3055 3060 Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 3065 3070 3075 Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln 3080 3085 3090 Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr 3095 3100 3105 Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu 3110 3115 3120 Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu 3125 3130 3135 Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys 3140 3145 3150 Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu 3155 3160 3165 Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu 3170 3175 3180 Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser 3185 3190 3195 Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp 3200 3205 3210 Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 3215 3220 3225 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln 3230 3235 3240 Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn 3245 3250 3255 Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys 3260 3265 3270 Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu 3275 3280 3285 Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala 3290 3295 3300 Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu 3305 3310 3315 Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn 3320 3325 3330 Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys 3335 3340 3345 Gly His Lys Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr 3350 3355 3360 Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn 3365 3370 3375 Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly 3380 3385 3390 Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr 3395 3400 3405 Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala 3410 3415 3420 Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu 3425 3430 3435 His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser 3440 3445 3450 Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu 3455 3460 3465 His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser 3470 3475 3480 Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu 3485 3490 3495 Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu 3500 3505 3510 Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys 3515 3520 3525 Gln Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro 3530 3535 3540 Glu Met Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu 3545 3550 3555 Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu 3560 3565 3570 Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser 3575 3580 3585 Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu 3590 3595 3600 Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr Ser Leu 3605 3610 3615 Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val Val Gly 3620 3625 3630 Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu Ser Pro 3635 3640 3645 Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln Leu 3650 3655 3660 Asn Asn Ser Phe Pro Ser Ser Arg Gly His Asn Val Gly Ser Leu 3665 3670 3675 Phe His Met Ala Asp Asp Leu Gly Arg Ala Met Glu Ser Leu Val 3680 3685 3690 Ser Val Met Thr Asp Glu Glu Gly Ala Glu 3695 3700 <210> 50 <211> 8499 <212> DNA <213> Homo sapiens <400> 50 tttcatcaga gcatcttcac acatcagtgt tcactctcta tagatttatt tgcatattgt 60 ctaaatatgt ttttttctgt tattatttta cactttttat tttgcttcat tctctgttga 120 gttcctcaaa cctttaaaaa ggaaataaat aacttattca cttaccctct aaattatatt 180 ctatgtggac ggtccctaat aaataatgag ttatcactcc aaattgtttc aaatcccaag 240 acaccagagg aatttagaag aaagaaaatg ttagaccaat ttcaatattt acttaattag 300 aatatctaaa accaagcatt caaaggataa ctgaaataat atttgggtta ttgagcgagg 360 atgacagtca tgcctttcat atttgtaaac ttcaaaggat gacaataaag ggacaacagc 420 ctttgaaatt ttgagagaag tatttgctgc ttgcaagtcg gttgatgtgg ttagctaact 480 gccctgggcc ctgtattggt tttgctcaat aggaaattga tcgggaattg cagaagaaga 540 aagaggagct gaatgcagtg cgtaggcaag ctgagggctt gtctgaggat ggggccgcaa 600 tggcagtgga gccaactcag atccagctca gcaagcgctg gcgggaaatt gagagcaaat 660 ttgctcagtt tcgaagactc aactttgcac aaattcacac tgtccgtgaa gaaacgatga 720 tggtgatgac tgaagacatg cctttggaaa tttcttatgt gccttctact tatttgactg 780 aaatcactca tgtctcacaa gccctattag aagtggaaca acttctcaat gctcctgacc 840 tctgtgctaa ggactttgaa gatctcttta agcaagagga gtctctgaag aatataaaag 900 atagtctaca acaaagctca ggtcggattg acattattca tagcaagaag acagcagcat 960 tgcaaagtgc aacgcctgtg gaaagggtga agctacagga agctctctcc cagcttgatt 1020 tccaatggga aaaagttaac aaaatgtaca aggaccgaca agggcgattt gacagatctg 1080 ttgagaaatg gcggcgtttt cattatgata taaagatatt taatcagtgg ctaacagaag 1140 ctgaacagtt tctcagaaag acacaaattc ctgagaattg ggaacatgct aaatacaaat 1200 ggtatcttaa ggaactccag gatggcattg ggcagcggca aactgttgtc agaacattga 1260 atgcaactgg ggaagaaata attcagcaat cctcaaaaac agatgccagt attctacagg 1320 aaaaattggg aagcctgaat ctgcggtggc aggaggtctg caaacagctg tcagacagaa 1380 aaaagaggct agaagaacaa aagaatatct tgtcagaatt tcaaagagat ttaaatgaat 1440 ttgttttatg gttggaggaa gcagataaca ttgctagtat cccacttgaa cctggaaaag 1500 agcagcaact aaaagaaaag cttgagcaag tcaagttact ggtggaagag ttgcccctgc 1560 gccagggaat tctcaaacaa ttaaatgaaa ctggaggacc cgtgcttgta agtgctccca 1620 taagcccaga agagcaagat aaacttgaaa ataagctcaa gcagacaaat ctccagtgga 1680 taaaggtttc cagagcttta cctgagaaac aaggagaaat tgaagctcaa ataaaagacc 1740 ttgggcagct tgaaaaaaag cttgaagacc ttgaagagca gttaaatcat ctgctgctgt 1800 ggttatctcc tattaggaat cagttggaaa tttataacca accaaaccaa gaaggaccat 1860 ttgacgttaa ggaaactgaa atagcagttc aagctaaaca accggatgtg gaagagattt 1920 tgtctaaagg gcagcatttg tacaaggaaa aaccagccac tcagccagtg aagaggaagt 1980 tagaagatct gagctctgag tggaaggcgg taaaccgttt acttcaagag ctgagggcaa 2040 agcagcctga cctagctcct ggactgacca ctattggagc ctctcctact cagactgtta 2100 ctctggtgac acaacctgtg gttactaagg aaactgccat ctccaaacta gaaatgccat 2160 cttccttgat gttggaggta cctgctctgg cagatttcaa ccgggcttgg acagaactta 2220 ccgactggct ttctctgctt gatcaagtta taaaatcaca gagggtgatg gtgggtgacc 2280 ttgaggatat caacgagatg atcatcaagc agaaggcaac aatgcaggat ttggaacaga 2340 ggcgtcccca gttggaagaa ctcattaccg ctgcccaaaa tttgaaaaac aagaccagca 2400 atcaagaggc tagaacaatc attacggatc gaattgaaag aattcagaat cagtgggatg 2460 aagtacaaga acaccttcag aaccggaggc aacagttgaa tgaaatgtta aaggattcaa 2520 cacaatggct ggaagctaag gaagaagctg agcaggtctt aggacaggcc agagccaagc 2580 ttgagtcatg gaaggagggt ccctatacag tagatgcaat ccaaaagaaa atcacagaaa 2640 ccaagcagtt ggccaaagac ctccgccagt ggcagacaaa tgtagatgtg gcaaatgact 2700 tggccctgaa acttctccgg gattattctg cagatgatac cagaaaagtc cacatgataa 2760 cagagaatat caatgcctct tggagaagca ttcataaaag ggtgagtgag cgagaggctg 2820 ctttggaaga aactcataga ttactgcaac agttccccct ggacctggaa aagtttcttg 2880 cctggcttac agaagctgaa acaactgcca atgtcctaca ggatgctacc cgtaaggaaa 2940 ggctcctaga agactccaag ggagtaaaag agctgatgaa acaatggcaa gacctccaag 3000 gtgaaattga agctcacaca gatgtttatc acaacctgga tgaaaacagc caaaaaatcc 3060 tgagatccct ggaaggttcc gatgatgcag tcctgttaca aagacgtttg gataacatga 3120 acttcaagtg gagtgaactt cggaaaaagt ctctcaacat taggtcccat ttggaagcca 3180 gttctgacca gtggaagcgt ctgcaccttt ctctgcagga acttctggtg tggctacagc 3240 tgaaagatga tgaattaagc cggcaggcac ctattggagg cgactttcca gcagttcaga 3300 agcagaacga tgtacatagg gccttcaaga gggaattgaa aactaaagaa cctgtaatca 3360 tgagtactct tgagactgta cgaatatttc tgacagagca gcctttggaa ggactagaga 3420 aactctacca ggagcccaga gagctgcctc ctgaggagag agcccagaat gtcactcggc 3480 ttctacgaaa gcaggctgag gaggtcaata ctgagtggga aaaattgaac ctgcactccg 3540 ctgactggca gagaaaaata gatgagaccc ttgaaagact ccgggaactt caagaggcca 3600 cggatgagct ggacctcaag ctgcgccaag ctgaggtgat caagggatcc tggcagcccg 3660 tgggcgatct cctcattgac tctctccaag atcacctcga gaaagtcaag gcacttcgag 3720 gagaaattgc gcctctgaaa gagaacgtga gccacgtcaa tgaccttgct cgccagctta 3780 ccactttggg cattcagctc tcaccgtata acctcagcac tctggaagac ctgaacacca 3840 gatggaagct tctgcaggtg gccgtcgagg accgagtcag gcagctgcat gaagcccaca 3900 gggactttgg tccagcatct cagcactttc tttccacgtc tgtccagggt ccctgggaga 3960 gagccatctc gccaaacaaa gtgccctact atatcaacca cgagactcaa acaacttgct 4020 gggaccatcc caaaatgaca gagctctacc agtctttagc tgacctgaat aatgtcagat 4080 tctcagctta taggactgcc atgaaactcc gaagactgca gaaggccctt tgcttggatc 4140 tcttgagcct gtcagctgca tgtgatgcct tggaccagca caacctcaag caaaatgacc 4200 agcccatgga tatcctgcag attattaatt gtttgaccac tatttatgac cgcctggagc 4260 aagagcacaa caatttggtc aacgtccctc tctgcgtgga tatgtgtctg aactggctgc 4320 tgaatgttta tgatacggga cgaacaggga ggatccgtgt cctgtctttt aaaactggca 4380 tcatttccct gtgtaaagca catttggaag acaagtacag ataccttttc aagcaagtgg 4440 caagttcaac aggattttgt gaccagcgca ggctgggcct ccttctgcat gattctatcc 4500 aaattccaag acagttgggt gaagttgcat cctttggggg cagtaacatt gagccaagtg 4560 tccggagctg cttccaattt gctaataata agccagagat cgaagcggcc ctcttcctag 4620 actggatgag actggaaccc cagtccatgg tgtggctgcc cgtcctgcac agagtggctg 4680 ctgcagaaac tgccaagcat caggccaaat gtaacatctg caaagagtgt ccaatcattg 4740 gattcaggta caggagtcta aagcacttta attatgacat ctgccaaagc tgcttttttt 4800 ctggtcgagt tgcaaaaggc cataaaatgc actatcccat ggtggaatat tgcactccga 4860 ctacatcagg agaagatgtt cgagactttg ccaaggtact aaaaaacaaa tttcgaacca 4920 aaaggtattt tgcgaagcat ccccgaatgg gctacctgcc agtgcagact gtcttagagg 4980 gggacaacat ggaaactccc gttactctga tcaacttctg gccagtagat tctgcgcctg 5040 cctcgtcccc tcagctttca cacgatgata ctcattcacg cattgaacat tatgctagca 5100 ggctagcaga aatggaaaac agcaatggat cttatctaaa tgatagcatc tctcctaatg 5160 agagcataga tgatgaacat ttgttaatcc agcattactg ccaaagtttg aaccaggact 5220 cccccctgag ccagcctcgt agtcctgccc agatcttgat ttccttagag agtgaggaaa 5280 gaggggagct agagagaatc ctagcagatc ttgaggaaga aaacaggaat ctgcaagcag 5340 aatatgaccg tctaaagcag cagcacgaac ataaaggcct gtccccactg ccgtcccctc 5400 ctgaaatgat gcccacctct ccccagagtc cccgggatgc tgagctcatt gctgaggcca 5460 agctactgcg tcaacacaaa ggccgcctgg aagccaggat gcaaatcctg gaagaccaca 5520 ataaacagct ggagtcacag ttacacaggc taaggcagct gctggagcaa ccccaggcag 5580 aggccaaagt gaatggcaca acggtgtcct ctccttctac ctctctacag aggtccgaca 5640 gcagtcagcc tatgctgctc cgagtggttg gcagtcaaac ttcggactcc atgggtgagg 5700 aagatcttct cagtcctccc caggacacaa gcacagggtt agaggaggtg atggagcaac 5760 tcaacaactc cttccctagt tcaagaggac acaatgtagg aagtcttttc cacatggcag 5820 atgatttggg cagagcgatg gagtccttag tatcagtcat gacagatgaa gaaggagcag 5880 aataaatgtt ttacaactcc tgattcccgc atggttttta taatattcat acaacaaaga 5940 ggattagaca gtaagagttt acaagaaata aatctatatt tttgtgaagg gtagtggtat 6000 tatactgtag atttcagtag tttctaagtc tgttattgtt ttgttaacaa tggcaggttt 6060 tacacgtcta tgcaattgta caaaaaagtt ataagaaaac tacatgtaaa atcttgatag 6120 ctaaataact tgccatttct ttatatggaa cgcattttgg gttgtttaaa aatttataac 6180 agttataaag aaagattgta aactaaagtg tgctttataa aaaaaagttg tttataaaaa 6240 cccctaaaaa caaaacaaac acacacacac acacatacac acacacacac aaaactttga 6300 ggcagcgcat tgttttgcat ccttttggcg tgatatccat atgaaattca tggctttttc 6360 tttttttgca tattaaagat aagacttcct ctaccaccac accaaatgac tactacacac 6420 tgctcatttg agaactgtca gctgagtggg gcaggcttga gttttcattt catatatcta 6480 tatgtctata agtatataaa tactatagtt atatagataa agagatacga atttctatag 6540 actgactttt tccatttttt aaatgttcat gtcacatcct aatagaaaga aattacttct 6600 agtcagtcat ccaggcttac ctgcttggtc tagaatggat ttttcccgga gccggaagcc 6660 aggaggaaac tacaccacac taaaacattg tctacagctc cagatgtttc tcattttaaa 6720 caactttcca ctgacaacga aagtaaagta aagtattgga tttttttaaa gggaacatgt 6780 gaatgaatac acaggactta ttatatcaga gtgagtaatc ggttggttgg ttgattgatt 6840 gattgattga tacattcagc ttcctgctgc tagcaatgcc acgatttaga tttaatgatg 6900 cttcagtgga aatcaatcag aaggtattct gaccttgtga acatcagaag gtatttttta 6960 actcccaagc agtagcagga cgatgatagg gctggagggc tatggattcc cagcccatcc 7020 ctgtgaagga gtaggccact ctttaagtga aggattggat gattgttcat aatacataaa 7080 gttctctgta attacaacta aattattatg ccctcttctc acagtcaaaa ggaactgggt 7140 ggtttggttt ttgttgcttt tttagattta ttgtcccatg tgggatgagt ttttaaatgc 7200 cacaagacat aatttaaaat aaataaactt tgggaaaagg tgtaaaacag tagccccatc 7260 acatttgtga tactgacagg tatcaaccca gaagcccatg aactgtgttt ccatcctttg 7320 catttctctg cgagtagttc cacacaggtt tgtaagtaag taagaaagaa ggcaaattga 7380 ttcaaatgtt acaaaaaaac ccttcttggt ggattagaca ggttaaatat ataaacaaac 7440 aaacaaaaat tgctcaaaaa agaggagaaa agctcaagag gaaaagctaa ggactggtag 7500 gaaaaagctt tactctttca tgccatttta tttctttttg atttttaaat cattcattca 7560 atagatacca ccgtgtgacc tataattttg caaatctgtt acctctgaca tcaagtgtaa 7620 ttagcttttg gagagtgggc tgacatcaag tgtaattagc ttttggagag tgggttttgt 7680 ccattattaa taattaatta attaacatca aacacggctt ctcatgctat ttctacctca 7740 ctttggtttt ggggtgttcc tgataattgt gcacacctga gttcacagct tcaccacttg 7800 tccattgcgt tattttcttt ttcctttata attctttctt tttccttcat aattttcaaa 7860 agaaaaccca aagctctaag gtaacaaatt accaaattac atgaagattt ggtttttgtc 7920 ttgcattttt ttcctttatg tgacgctgga ccttttcttt acccaaggat ttttaaaact 7980 cagatttaaa acaaggggtt actttacatc ctactaagaa gtttaagtaa gtaagtttca 8040 ttctaaaatc agaggtaaat agagtgcata aataattttg ttttaatctt tttgtttttc 8100 ttttagacac attagctctg gagtgagtct gtcataatat ttgaacaaaa attgagagct 8160 ttattgctgc attttaagca taattaattt ggacattatt tcgtgttgtg ttctttataa 8220 ccaccaagta ttaaactgta aatcataatg taactgaagc ataaacatca catggcatgt 8280 tttgtcattg ttttcaggta ctgagttctt acttgagtat cataatatat tgtgttttaa 8340 caccaacact gtaacattta cgaattattt ttttaaactt cagttttact gcattttcac 8400 aacatatcag acttcaccaa atatatgcct tactattgta ttatagtact gctttactgt 8460 gtatctcaat aaagcacgca gttatgttac aaaaaagta 8499 <210> 51 <211> 1761 <212> PRT <213> Homo sapiens <400> 51 Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser Lys Arg Trp Arg Glu 1 5 10 15 Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg Leu Asn Phe Ala Gln Ile 20 25 30 His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro 35 40 45 Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His 50 55 60 Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp 65 70 75 80 Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu 85 90 95 Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile 100 105 110 Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu 115 120 125 Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu 130 135 140 Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser 145 150 155 160 Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 165 170 175 Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu 180 185 190 Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp 195 200 205 Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly 210 215 220 Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln 225 230 235 240 Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln 245 250 255 Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Lys Asn Ile Leu Ser 260 265 270 Glu Phe Gln Arg Asp Leu Asn Glu Phe Val Leu Trp Leu Glu Glu Ala 275 280 285 Asp Asn Ile Ala Ser Ile Pro Leu Glu Pro Gly Lys Glu Gln Gln Leu 290 295 300 Lys Glu Lys Leu Glu Gln Val Lys Leu Leu Val Glu Glu Leu Pro Leu 305 310 315 320 Arg Gln Gly Ile Leu Lys Gln Leu Asn Glu Thr Gly Gly Pro Val Leu 325 330 335 Val Ser Ala Pro Ile Ser Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys 340 345 350 Leu Lys Gln Thr Asn Leu Gln Trp Ile Lys Val Ser Arg Ala Leu Pro 355 360 365 Glu Lys Gln Gly Glu Ile Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu 370 375 380 Glu Lys Lys Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu 385 390 395 400 Trp Leu Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn 405 410 415 Gln Glu Gly Pro Phe Asp Val Lys Glu Thr Glu Ile Ala Val Gln Ala 420 425 430 Lys Gln Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His Leu Tyr 435 440 445 Lys Glu Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu Glu Asp Leu 450 455 460 Ser Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln Glu Leu Arg Ala 465 470 475 480 Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro 485 490 495 Thr Gln Thr Val Thr Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr 500 505 510 Ala Ile Ser Lys Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro 515 520 525 Ala Leu Ala Asp Phe Asn Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu 530 535 540 Ser Leu Leu Asp Gln Val Ile Lys Ser Gln Arg Val Met Val Gly Asp 545 550 555 560 Leu Glu Asp Ile Asn Glu Met Ile Ile Lys Gln Lys Ala Thr Met Gln 565 570 575 Asp Leu Glu Gln Arg Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala 580 585 590 Gln Asn Leu Lys Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile 595 600 605 Thr Asp Arg Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu 610 615 620 His Leu Gln Asn Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser 625 630 635 640 Thr Gln Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln 645 650 655 Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp 660 665 670 Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu 675 680 685 Arg Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu Ala Leu Lys 690 695 700 Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys Val His Met Ile 705 710 715 720 Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile His Lys Arg Val Ser 725 730 735 Glu Arg Glu Ala Ala Leu Glu Glu Thr His Arg Leu Leu Gln Gln Phe 740 745 750 Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr 755 760 765 Thr Ala Asn Val Leu Gln Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu 770 775 780 Asp Ser Lys Gly Val Lys Glu Leu Met Lys Gln Trp Gln Asp Leu Gln 785 790 795 800 Gly Glu Ile Glu Ala His Thr Asp Val Tyr His Asn Leu Asp Glu Asn 805 810 815 Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu 820 825 830 Leu Gln Arg Arg Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg 835 840 845 Lys Lys Ser Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln 850 855 860 Trp Lys Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln 865 870 875 880 Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe 885 890 895 Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg Glu 900 905 910 Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr Val Arg 915 920 925 Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln 930 935 940 Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn Val Thr Arg 945 950 955 960 Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr Glu Trp Glu Lys Leu 965 970 975 Asn Leu His Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu 980 985 990 Arg Leu Arg Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu 995 1000 1005 Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp 1010 1015 1020 Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala 1025 1030 1035 Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val 1040 1045 1050 Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser 1055 1060 1065 Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys 1070 1075 1080 Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu 1085 1090 1095 Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr 1100 1105 1110 Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val 1115 1120 1125 Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His 1130 1135 1140 Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 1145 1150 1155 Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu 1160 1165 1170 Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys 1175 1180 1185 Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met 1190 1195 1200 Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg 1205 1210 1215 Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val 1220 1225 1230 Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg 1235 1240 1245 Thr Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser 1250 1255 1260 Leu Cys Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys 1265 1270 1275 Gln Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly 1280 1285 1290 Leu Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu 1295 1300 1305 Val Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser 1310 1315 1320 Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu 1325 1330 1335 Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met Val Trp Leu 1340 1345 1350 Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln 1355 1360 1365 Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe Arg 1370 1375 1380 Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 1385 1390 1395 Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro 1400 1405 1410 Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg 1415 1420 1425 Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr 1430 1435 1440 Phe Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val 1445 1450 1455 Leu Glu Gly Asp Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe 1460 1465 1470 Trp Pro Val Asp Ser Ala Pro Ala Ser Ser Pro Gln Leu Ser His 1475 1480 1485 Asp Asp Thr His Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala 1490 1495 1500 Glu Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser 1505 1510 1515 Pro Asn Glu Ser Ile Asp Asp Glu His Leu Leu Ile Gln His Tyr 1520 1525 1530 Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro Arg Ser 1535 1540 1545 Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu Arg Gly Glu 1550 1555 1560 Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn Leu 1565 1570 1575 Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys Gly 1580 1585 1590 Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro 1595 1600 1605 Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu Leu 1610 1615 1620 Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu 1625 1630 1635 Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln 1640 1645 1650 Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr 1655 1660 1665 Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln 1670 1675 1680 Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met 1685 1690 1695 Gly Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly 1700 1705 1710 Leu Glu Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser 1715 1720 1725 Arg Gly His Asn Val Gly Ser Leu Phe His Met Ala Asp Asp Leu 1730 1735 1740 Gly Arg Ala Met Glu Ser Leu Val Ser Val Met Thr Asp Glu Glu 1745 1750 1755 Gly Ala Glu 1760 <210> 52 <211> 13875 <212> DNA <213> Homo sapiens <400> 52 actttccccc tacaggactc agatctggga ggcaattacc ttcggagaaa aacgaatagg 60 aaaaactgaa gtgttacttt ttttaaagct gctgaagttt gttggtttct cattgttttt 120 aagcctactg gagcaataaa gtttgaagaa cttttaccag gtttttttta tcgctgcctt 180 gatatacact tttcaaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag 240 atgttcaaaa gaaaacattc acaaaatggg taaatgcaca attttctaag tttgggaagc 300 agcatattga gaacctcttc agtgacctac aggatgggag gcgcctccta gacctcctcg 360 aaggcctgac agggcaaaaa ctgccaaaag aaaaaggatc cacaagagtt catgccctga 420 acaatgtcaa caaggcactg cgggttttgc agaacaataa tgttgattta gtgaatattg 480 gaagtactga catcgtagat ggaaatcata aactgactct tggtttgatt tggaatataa 540 tcctccactg gcaggtcaaa aatgtaatga aaaatatcat ggctggattg caacaaacca 600 acagtgaaaa gattctcctg agctgggtcc gacaatcaac tcgtaattat ccacaggtta 660 atgtaatcaa cttcaccacc agctggtctg atggcctggc tttgaatgct ctcatccata 720 gtcataggcc agacctattt gactggaata gtgtggtttg ccagcagtca gccacacaac 780 gactggaaca tgcattcaac atcgccagat atcaattagg catagagaaa ctactcgatc 840 ctgaagatgt tgataccacc tatccagata agaagtccat cttaatgtac atcacatcac 900 tcttccaagt tttgcctcaa caagtgagca ttgaagccat ccaggaagtg gaaatgttgc 960 caaggccacc taaagtgact aaagaagaac attttcagtt acatcatcaa atgcactatt 1020 ctcaacagat cacggtcagt ctagcacagg gatatgagag aacttcttcc cctaagcctc 1080 gattcaagag ctatgcctac acacaggctg cttatgtcac cacctctgac cctacacgga 1140 gcccatttcc ttcacagcat ttggaagctc ctgaagacaa gtcatttggc agttcattga 1200 tggagagtga agtaaacctg gaccgttatc aaacagcttt agaagaagta ttatcgtggc 1260 ttctttctgc tgaggacaca ttgcaagcac aaggagagat ttctaatgat gtggaagtgg 1320 tgaaagacca gtttcatact catgaggggt acatgatgga tttgacagcc catcagggcc 1380 gggttggtaa tattctacaa ttgggaagta agctgattgg aacaggaaaa ttatcagaag 1440 atgaagaaac tgaagtacaa gagcagatga atctcctaaa ttcaagatgg gaatgcctca 1500 gggtagctag catggaaaaa caaagcaatt tacatagagt tttaatggat ctccagaatc 1560 agaaactgaa agagttgaat gactggctaa caaaaacaga agaaagaaca aggaaaatgg 1620 aggaagagcc tcttggacct gatcttgaag acctaaaacg ccaagtacaa caacataagg 1680 tgcttcaaga agatctagaa caagaacaag tcagggtcaa ttctctcact cacatggtgg 1740 tggtagttga tgaatctagt ggagatcacg caactgctgc tttggaagaa caacttaagg 1800 tattgggaga tcgatgggca aacatctgta gatggacaga agaccgctgg gttcttttac 1860 aagacatcct tctcaaatgg caacgtctta ctgaagaaca gtgccttttt agtgcatggc 1920 tttcagaaaa agaagatgca gtgaacaaga ttcacacaac tggctttaaa gatcaaaatg 1980 aaatgttatc aagtcttcaa aaactggccg ttttaaaagc ggatctagaa aagaaaaagc 2040 aatccatggg caaactgtat tcactcaaac aagatcttct ttcaacactg aagaataagt 2100 cagtgaccca gaagacggaa gcatggctgg ataactttgc ccggtgttgg gataatttag 2160 tccaaaaact tgaaaagagt acagcacaga tttcacaggc tgtcaccacc actcagccat 2220 cactaacaca gacaactgta atggaaacag taactacggt gaccacaagg gaacagatcc 2280 tggtaaagca tgctcaagag gaacttccac caccacctcc ccaaaagaag aggcagatta 2340 ctgtggattc tgaaattagg aaaaggttgg atgttgatat aactgaactt cacagctgga 2400 ttactcgctc agaagctgtg ttgcagagtc ctgaatttgc aatctttcgg aaggaaggca 2460 acttctcaga cttaaaagaa aaagtcaatg ccatagagcg agaaaaagct gagaagttca 2520 gaaaactgca agatgccagc agatcagctc aggccctggt ggaacagatg gtgaatgagg 2580 gtgttaatgc agatagcatc aaacaagcct cagaacaact gaacagccgg tggatcgaat 2640 tctgccagtt gctaagtgag agacttaact ggctggagta tcagaacaac atcatcgctt 2700 tctataatca gctacaacaa ttggagcaga tgacaactac tgctgaaaac tggttgaaaa 2760 tccaacccac caccccatca gagccaacag caattaaaag tcagttaaaa atttgtaagg 2820 atgaagtcaa ccggctatca gatcttcaac ctcaaattga acgattaaaa attcaaagca 2880 tagccctgaa agagaaagga caaggaccca tgttcctgga tgcagacttt gtggccttta 2940 caaatcattt taagcaagtc ttttctgatg tgcaggccag agagaaagag ctacagacaa 3000 tttttgacac tttgccacca atgcgctatc aggagaccat gagtgccatc aggacatggg 3060 tccagcagtc agaaaccaaa ctctccatac ctcaacttag tgtcaccgac tatgaaatca 3120 tggagcagag actcggggaa ttgcaggctt tacaaagttc tctgcaagag caacaaagtg 3180 gcctatacta tctcagcacc actgtgaaag agatgtcgaa gaaagcgccc tctgaaatta 3240 gccggaaata tcaatcagaa tttgaagaaa ttgagggacg ctggaagaag ctctcctccc 3300 agctggttga gcattgtcaa aagctagagg agcaaatgaa taaactccga aaaattcaga 3360 atcacataca aaccctgaag aaatggatgg ctgaagttga tgtttttctg aaggaggaat 3420 ggcctgccct tggggattca gaaattctaa aaaagcagct gaaacagtgc agacttttag 3480 tcagtgatat tcagacaatt cagcccagtc taaacagtgt caatgaaggt gggcagaaga 3540 taaagaatga agcagagcca gagtttgctt cgagacttga gacagaactc aaagaactta 3600 acactcagtg ggatcacatg tgccaacagg tctatgccag aaaggaggcc ttgaagggag 3660 gtttggagaa aactgtaagc ctccagaaag atctatcaga gatgcacgaa tggatgacac 3720 aagctgaaga agagtatctt gagagagatt ttgaatataa aactccagat gaattacaga 3780 aagcagttga agagatgaag agagctaaag aagaggccca acaaaaagaa gcgaaagtga 3840 aactccttac tgagtctgta aatagtgtca tagctcaagc tccacctgta gcacaagagg 3900 ccttaaaaaa ggaacttgaa actctaacca ccaactacca gtggctctgc actaggctga 3960 atgggaaatg caagactttg gaagaagttt gggcatgttg gcatgagtta ttgtcatact 4020 tggagaaagc aaacaagtgg ctaaatgaag tagaatttaa acttaaaacc actgaaaaca 4080 ttcctggcgg agctgaggaa atctctgagg tgctagattc acttgaaaat ttgatgcgac 4140 attcagagga taacccaaat cagattcgca tattggcaca gaccctaaca gatggcggag 4200 tcatggatga gctaatcaat gaggaacttg agacatttaa ttctcgttgg agggaactac 4260 atgaagaggc tgtaaggagg caaaagttgc ttgaacagag catccagtct gcccaggaga 4320 ctgaaaaatc cttacactta atccaggagt ccctcacatt cattgacaag cagttggcag 4380 cttatattgc agacaaggtg gacgcagctc aaatgcctca ggaagcccag aaaatccaat 4440 ctgatttgac aagtcatgag atcagtttag aagaaatgaa gaaacataat caggggaagg 4500 aggctgccca aagagtcctg tctcagattg atgttgcaca gaaaaaatta caagatgtct 4560 ccatgaagtt tcgattattc cagaaaccag ccaattttga gcagcgtcta caagaaagta 4620 agatgatttt agatgaagtg aagatgcact tgcctgcatt ggaaacaaag agtgtggaac 4680 aggaagtagt acagtcacag ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag 4740 tgaagtctga agtggaaatg gtgataaaga ctggacgtca gattgtacag aaaaagcaga 4800 cggaaaatcc caaagaactt gatgaaagag taacagcttt gaaattgcat tataatgagc 4860 tgggagcaaa ggtaacagaa agaaagcaac agttggagaa atgcttgaaa ttgtcccgta 4920 agatgcgaaa ggaaatgaat gtcttgacag aatggctggc agctacagat atggaattga 4980 caaagagatc agcagttgaa ggaatgccta gtaatttgga ttctgaagtt gcctggggaa 5040 aggctactca aaaagagatt gagaaacaga aggtgcacct gaagagtatc acagaggtag 5100 gagaggcctt gaaaacagtt ttgggcaaga aggagacgtt ggtggaagat aaactcagtc 5160 ttctgaatag taactggata gctgtcacct cccgagcaga agagtggtta aatcttttgt 5220 tggaatacca gaaacacatg gaaacttttg accagaatgt ggaccacatc acaaagtgga 5280 tcattcaggc tgacacactt ttggatgaat cagagaaaaa gaaaccccag caaaaagaag 5340 acgtgcttaa gcgtttaaag gcagaactga atgacatacg cccaaaggtg gactctacac 5400 gtgaccaagc agcaaacttg atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc 5460 cccaaatctc agagctcaac catcgatttg cagccatttc acacagaatt aagactggaa 5520 aggcctccat tcctttgaag gaattggagc agtttaactc agatatacaa aaattgcttg 5580 aaccactgga ggctgaaatt cagcaggggg tgaatctgaa agaggaagac ttcaataaag 5640 atatgaatga agacaatgag ggtactgtaa aagaattgtt gcaaagagga gacaacttac 5700 aacaaagaat cacagatgag agaaagcgag aggaaataaa gataaaacag cagctgttac 5760 agacaaaaca taatgctctc aaggatttga ggtctcaaag aagaaaaaag gctctagaaa 5820 tttctcatca gtggtatcag tacaagaggc aggctgatga tctcctgaaa tgcttggatg 5880 acattgaaaa aaaattagcc agcctacctg agcccagaga tgaaaggaaa ataaaggaaa 5940 ttgatcggga attgcagaag aagaaagagg agctgaatgc agtgcgtagg caagctgagg 6000 gcttgtctga ggatggggcc gcaatggcag tggagccaac tcagatccag ctcagcaagc 6060 gctggcggga aattgagagc aaatttgctc agtttcgaag actcaacttt gcacaaattc 6120 acactgtccg tgaagaaacg atgatggtga tgactgaaga catgcctttg gaaatttctt 6180 atgtgccttc tacttatttg actgaaatca ctcatgtctc acaagcccta ttagaagtgg 6240 aacaacttct caatgctcct gacctctgtg ctaaggactt tgaagatctc tttaagcaag 6300 aggagtctct gaagaatata aaagatagtc tacaacaaag ctcaggtcgg attgacatta 6360 ttcatagcaa gaagacagca gcattgcaaa gtgcaacgcc tgtggaaagg gtgaagctac 6420 aggaagctct ctcccagctt gatttccaat gggaaaaagt taacaaaatg tacaaggacc 6480 gacaagggcg atttgacaga tctgttgaga aatggcggcg ttttcattat gatataaaga 6540 tatttaatca gtggctaaca gaagctgaac agtttctcag aaagacacaa attcctgaga 6600 attgggaaca tgctaaatac aaatggtatc ttaaggaact ccaggatggc attgggcagc 6660 ggcaaactgt tgtcagaaca ttgaatgcaa ctggggaaga aataattcag caatcctcaa 6720 aaacagatgc cagtattcta caggaaaaat tgggaagcct gaatctgcgg tggcaggagg 6780 tctgcaaaca gctgtcagac agaaaaaaga ggctagaaga acaaaagaat atcttgtcag 6840 aatttcaaag agatttaaat gaatttgttt tatggttgga ggaagcagat aacattgcta 6900 gtatcccact tgaacctgga aaagagcagc aactaaaaga aaagcttgag caagtcaagt 6960 tactggtgga agagttgccc ctgcgccagg gaattctcaa acaattaaat gaaactggag 7020 gacccgtgct tgtaagtgct cccataagcc cagaagagca agataaactt gaaaataagc 7080 tcaagcagac aaatctccag tggataaagg tttccagagc tttacctgag aaacaaggag 7140 aaattgaagc tcaaataaaa gaccttgggc agcttgaaaa aaagcttgaa gaccttgaag 7200 agcagttaaa tcatctgctg ctgtggttat ctcctattag gaatcagttg gaaatttata 7260 accaaccaaa ccaagaagga ccatttgacg ttaaggaaac tgaaatagca gttcaagcta 7320 aacaaccgga tgtggaagag attttgtcta aagggcagca tttgtacaag gaaaaaccag 7380 ccactcagcc agtgaagagg aagttagaag atctgagctc tgagtggaag gcggtaaacc 7440 gtttacttca agagctgagg gcaaagcagc ctgacctagc tcctggactg accactattg 7500 gagcctctcc tactcagact gttactctgg tgacacaacc tgtggttact aaggaaactg 7560 ccatctccaa actagaaatg ccatcttcct tgatgttgga ggtacctgct ctggcagatt 7620 tcaaccgggc ttggacagaa cttaccgact ggctttctct gcttgatcaa gttataaaat 7680 cacagagggt gatggtgggt gaccttgagg atatcaacga gatgatcatc aagcagaagg 7740 caacaatgca ggatttggaa cagaggcgtc cccagttgga agaactcatt accgctgccc 7800 aaaatttgaa aaacaagacc agcaatcaag aggctagaac aatcattacg gatcgaattg 7860 aaagaattca gaatcagtgg gatgaagtac aagaacacct tcagaaccgg aggcaacagt 7920 tgaatgaaat gttaaaggat tcaacacaat ggctggaagc taaggaagaa gctgagcagg 7980 tcttaggaca ggccagagcc aagcttgagt catggaagga gggtccctat acagtagatg 8040 caatccaaaa gaaaatcaca gaaaccaagc agttggccaa agacctccgc cagtggcaga 8100 caaatgtaga tgtggcaaat gacttggccc tgaaacttct ccgggattat tctgcagatg 8160 ataccagaaa agtccacatg ataacagaga atatcaatgc ctcttggaga agcattcata 8220 aaagggtgag tgagcgagag gctgctttgg aagaaactca tagattactg caacagttcc 8280 ccctggacct ggaaaagttt cttgcctggc ttacagaagc tgaaacaact gccaatgtcc 8340 tacaggatgc tacccgtaag gaaaggctcc tagaagactc caagggagta aaagagctga 8400 tgaaacaatg gcaagacctc caaggtgaaa ttgaagctca cacagatgtt tatcacaacc 8460 tggatgaaaa cagccaaaaa atcctgagat ccctggaagg ttccgatgat gcagtcctgt 8520 tacaaagacg tttggataac atgaacttca agtggagtga acttcggaaa aagtctctca 8580 acattaggtc ccatttggaa gccagttctg accagtggaa gcgtctgcac ctttctctgc 8640 aggaacttct ggtgtggcta cagctgaaag atgatgaatt aagccggcag gcacctattg 8700 gaggcgactt tccagcagtt cagaagcaga acgatgtaca tagggccttc aagagggaat 8760 tgaaaactaa agaacctgta atcatgagta ctcttgagac tgtacgaata tttctgacag 8820 agcagccttt ggaaggacta gagaaactct accaggagcc cagagagctg cctcctgagg 8880 agagagccca gaatgtcact cggcttctac gaaagcaggc tgaggaggtc aatactgagt 8940 gggaaaaatt gaacctgcac tccgctgact ggcagagaaa aatagatgag acccttgaaa 9000 gactccggga acttcaagag gccacggatg agctggacct caagctgcgc caagctgagg 9060 tgatcaaggg atcctggcag cccgtgggcg atctcctcat tgactctctc caagatcacc 9120 tcgagaaagt caaggcactt cgaggagaaa ttgcgcctct gaaagagaac gtgagccacg 9180 tcaatgacct tgctcgccag cttaccactt tgggcattca gctctcaccg tataacctca 9240 gcactctgga agacctgaac accagatgga agcttctgca ggtggccgtc gaggaccgag 9300 tcaggcagct gcatgaagcc cacagggact ttggtccagc atctcagcac tttctttcca 9360 cgtctgtcca gggtccctgg gagagagcca tctcgccaaa caaagtgccc tactatatca 9420 accacgagac tcaaacaact tgctgggacc atcccaaaat gacagagctc taccagtctt 9480 tagctgacct gaataatgtc agattctcag cttataggac tgccatgaaa ctccgaagac 9540 tgcagaaggc cctttgcttg gatctcttga gcctgtcagc tgcatgtgat gccttggacc 9600 agcacaacct caagcaaaat gaccagccca tggatatcct gcagattatt aattgtttga 9660 ccactattta tgaccgcctg gagcaagagc acaacaattt ggtcaacgtc cctctctgcg 9720 tggatatgtg tctgaactgg ctgctgaatg tttatgatac gggacgaaca gggaggatcc 9780 gtgtcctgtc ttttaaaact ggcatcattt ccctgtgtaa agcacatttg gaagacaagt 9840 acagatacct tttcaagcaa gtggcaagtt caacaggatt ttgtgaccag cgcaggctgg 9900 gcctccttct gcatgattct atccaaattc caagacagtt gggtgaagtt gcatcctttg 9960 ggggcagtaa cattgagcca agtgtccgga gctgcttcca atttgctaat aataagccag 10020 agatcgaagc ggccctcttc ctagactgga tgagactgga accccagtcc atggtgtggc 10080 tgcccgtcct gcacagagtg gctgctgcag aaactgccaa gcatcaggcc aaatgtaaca 10140 tctgcaaaga gtgtccaatc attggattca ggtacaggag tctaaagcac tttaattatg 10200 acatctgcca aagctgcttt ttttctggtc gagttgcaaa aggccataaa atgcactatc 10260 ccatggtgga atattgcact ccgactacat caggagaaga tgttcgagac tttgccaagg 10320 tactaaaaaa caaatttcga accaaaaggt attttgcgaa gcatccccga atgggctacc 10380 tgccagtgca gactgtctta gagggggaca acatggaaac gcctgcctcg tcccctcagc 10440 tttcacacga tgatactcat tcacgcattg aacattatgc tagcaggcta gcagaaatgg 10500 aaaacagcaa tggatcttat ctaaatgata gcatctctcc taatgagagc atagatgatg 10560 aacatttgtt aatccagcat tactgccaaa gtttgaacca ggactccccc ctgagccagc 10620 ctcgtagtcc tgcccagatc ttgatttcct tagagagtga ggaaagaggg gagctagaga 10680 gaatcctagc agatcttgag gaagaaaaca ggaatctgca agcagaatat gaccgtctaa 10740 agcagcagca cgaacataaa ggcctgtccc cactgccgtc ccctcctgaa atgatgccca 10800 cctctcccca gagtccccgg gatgctgagc tcattgctga ggccaagcta ctgcgtcaac 10860 acaaaggccg cctggaagcc aggatgcaaa tcctggaaga ccacaataaa cagctggagt 10920 cacagttaca caggctaagg cagctgctgg agcaacccca ggcagaggcc aaagtgaatg 10980 gcacaacggt gtcctctcct tctacctctc tacagaggtc cgacagcagt cagcctatgc 11040 tgctccgagt ggttggcagt caaacttcgg actccatggg tgaggaagat cttctcagtc 11100 ctccccagga cacaagcaca gggttagagg aggtgatgga gcaactcaac aactccttcc 11160 ctagttcaag aggacacaat gtaggaagtc ttttccacat ggcagatgat ttgggcagag 11220 cgatggagtc cttagtatca gtcatgacag atgaagaagg agcagaataa atgttttaca 11280 actcctgatt cccgcatggt ttttataata ttcatacaac aaagaggatt agacagtaag 11340 agtttacaag aaataaatct atatttttgt gaagggtagt ggtattatac tgtagatttc 11400 agtagtttct aagtctgtta ttgttttgtt aacaatggca ggttttacac gtctatgcaa 11460 ttgtacaaaa aagttataag aaaactacat gtaaaatctt gatagctaaa taacttgcca 11520 tttctttata tggaacgcat tttgggttgt ttaaaaattt ataacagtta taaagaaaga 11580 ttgtaaacta aagtgtgctt tataaaaaaa agttgtttat aaaaacccct aaaaacaaaa 11640 caaacacaca cacacacaca tacacacaca cacacaaaac tttgaggcag cgcattgttt 11700 tgcatccttt tggcgtgata tccatatgaa attcatggct ttttcttttt ttgcatatta 11760 aagataagac ttcctctacc accacaccaa atgactacta cacactgctc atttgagaac 11820 tgtcagctga gtggggcagg cttgagtttt catttcatat atctatatgt ctataagtat 11880 ataaatacta tagttatata gataaagaga tacgaatttc tatagactga ctttttccat 11940 tttttaaatg ttcatgtcac atcctaatag aaagaaatta cttctagtca gtcatccagg 12000 cttacctgct tggtctagaa tggatttttc ccggagccgg aagccaggag gaaactacac 12060 cacactaaaa cattgtctac agctccagat gtttctcatt ttaaacaact ttccactgac 12120 aacgaaagta aagtaaagta ttggattttt ttaaagggaa catgtgaatg aatacacagg 12180 acttattata tcagagtgag taatcggttg gttggttgat tgattgattg attgatacat 12240 tcagcttcct gctgctagca atgccacgat ttagatttaa tgatgcttca gtggaaatca 12300 atcagaaggt attctgacct tgtgaacatc agaaggtatt ttttaactcc caagcagtag 12360 caggacgatg atagggctgg agggctatgg attcccagcc catccctgtg aaggagtagg 12420 ccactcttta agtgaaggat tggatgattg ttcataatac ataaagttct ctgtaattac 12480 aactaaatta ttatgccctc ttctcacagt caaaaggaac tgggtggttt ggtttttgtt 12540 gcttttttag atttattgtc ccatgtggga tgagttttta aatgccacaa gacataattt 12600 aaaataaata aactttggga aaaggtgtaa aacagtagcc ccatcacatt tgtgatactg 12660 acaggtatca acccagaagc ccatgaactg tgtttccatc ctttgcattt ctctgcgagt 12720 agttccacac aggtttgtaa gtaagtaaga aagaaggcaa attgattcaa atgttacaaa 12780 aaaacccttc ttggtggatt agacaggtta aatatataaa caaacaaaca aaaattgctc 12840 aaaaaagagg agaaaagctc aagaggaaaa gctaaggact ggtaggaaaa agctttactc 12900 tttcatgcca ttttatttct ttttgatttt taaatcattc attcaataga taccaccgtg 12960 tgacctataa ttttgcaaat ctgttacctc tgacatcaag tgtaattagc ttttggagag 13020 tgggctgaca tcaagtgtaa ttagcttttg gagagtgggt tttgtccatt attaataatt 13080 aattaattaa catcaaacac ggcttctcat gctatttcta cctcactttg gttttggggt 13140 gttcctgata attgtgcaca cctgagttca cagcttcacc acttgtccat tgcgttattt 13200 tctttttcct ttataattct ttctttttcc ttcataattt tcaaaagaaa acccaaagct 13260 ctaaggtaac aaattaccaa attacatgaa gatttggttt ttgtcttgca tttttttcct 13320 ttatgtgacg ctggaccttt tctttaccca aggattttta aaactcagat ttaaaacaag 13380 gggttacttt acatcctact aagaagttta agtaagtaag tttcattcta aaatcagagg 13440 taaatagagt gcataaataa ttttgtttta atctttttgt ttttctttta gacacattag 13500 ctctggagtg agtctgtcat aatatttgaa caaaaattga gagctttatt gctgcatttt 13560 aagcataatt aatttggaca ttatttcgtg ttgtgttctt tataaccacc aagtattaaa 13620 ctgtaaatca taatgtaact gaagcataaa catcacatgg catgttttgt cattgttttc 13680 aggtactgag ttcttacttg agtatcataa tatattgtgt tttaacacca acactgtaac 13740 atttacgaat tattttttta aacttcagtt ttactgcatt ttcacaacat atcagacttc 13800 accaaatata tgccttacta ttgtattata gtactgcttt actgtgtatc tcaataaagc 13860 acgcagttat gttac 13875 <210> 53 <211> 3690 <212> PRT <213> Homo sapiens <400> 53 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser 1775 1780 1785 Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln 1790 1795 1800 Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu 1805 1810 1815 Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn 1820 1825 1830 Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys 1835 1840 1845 Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp 1850 1855 1860 Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln 1865 1870 1875 Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu 1880 1885 1890 Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp 1895 1900 1905 Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys 1910 1915 1920 Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu 1925 1930 1935 Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser 1940 1945 1950 Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg 1955 1960 1965 Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met 1970 1975 1980 Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser 1985 1990 1995 Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu 2000 2005 2010 Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe 2015 2020 2025 Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp 2030 2035 2040 Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys 2045 2050 2055 Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 2060 2065 2070 Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 2075 2080 2085 Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 2090 2095 2100 Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 2105 2110 2115 Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro 2120 2125 2130 Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu 2135 2140 2145 Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 2150 2155 2160 Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala 2165 2170 2175 Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln 2180 2185 2190 Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu 2195 2200 2205 Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe 2210 2215 2220 Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu 2225 2230 2235 Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val 2240 2245 2250 Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys 2255 2260 2265 Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile 2270 2275 2280 Ser Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr 2285 2290 2295 Asn Leu Gln Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln 2300 2305 2310 Gly Glu Ile Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys 2315 2320 2325 Lys Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp 2330 2335 2340 Leu Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn 2345 2350 2355 Gln Glu Gly Pro Phe Asp Val Lys Glu Thr Glu Ile Ala Val Gln 2360 2365 2370 Ala Lys Gln Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His 2375 2380 2385 Leu Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu 2390 2395 2400 Glu Asp Leu Ser Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln 2405 2410 2415 Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr 2420 2425 2430 Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro 2435 2440 2445 Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser 2450 2455 2460 Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala 2465 2470 2475 Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile 2480 2485 2490 Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 2495 2500 2505 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg 2510 2515 2520 Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys 2525 2530 2535 Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg 2540 2545 2550 Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu 2555 2560 2565 Gln Asn Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr 2570 2575 2580 Gln Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln 2585 2590 2595 Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val 2600 2605 2610 Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys 2615 2620 2625 Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu 2630 2635 2640 Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys 2645 2650 2655 Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile 2660 2665 2670 His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His 2675 2680 2685 Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala 2690 2695 2700 Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala 2705 2710 2715 Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu 2720 2725 2730 Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 2735 2740 2745 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu 2750 2755 2760 Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg 2765 2770 2775 Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser 2780 2785 2790 Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys 2795 2800 2805 Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu 2810 2815 2820 Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe 2825 2830 2835 Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg 2840 2845 2850 Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr 2855 2860 2865 Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 2870 2875 2880 Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln 2885 2890 2895 Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr 2900 2905 2910 Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys 2915 2920 2925 Ile Asp Glu Thr Leu Glu Arg Leu Arg Glu Leu Gln Glu Ala Thr 2930 2935 2940 Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly 2945 2950 2955 Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp 2960 2965 2970 His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 2975 2980 2985 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 2990 2995 3000 Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 3005 3010 3015 Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 3020 3025 3030 Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala 3035 3040 3045 Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg 3050 3055 3060 Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 3065 3070 3075 Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln 3080 3085 3090 Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr 3095 3100 3105 Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu 3110 3115 3120 Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu 3125 3130 3135 Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys 3140 3145 3150 Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu 3155 3160 3165 Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu 3170 3175 3180 Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser 3185 3190 3195 Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp 3200 3205 3210 Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 3215 3220 3225 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln 3230 3235 3240 Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn 3245 3250 3255 Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys 3260 3265 3270 Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu 3275 3280 3285 Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala 3290 3295 3300 Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu 3305 3310 3315 Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn 3320 3325 3330 Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys 3335 3340 3345 Gly His Lys Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr 3350 3355 3360 Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn 3365 3370 3375 Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly 3380 3385 3390 Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr 3395 3400 3405 Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg 3410 3415 3420 Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn 3425 3430 3435 Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp 3440 3445 3450 Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln 3455 3460 3465 Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile 3470 3475 3480 Ser Leu Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala 3485 3490 3495 Asp Leu Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg 3500 3505 3510 Leu Lys Gln Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser 3515 3520 3525 Pro Pro Glu Met Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala 3530 3535 3540 Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg 3545 3550 3555 Leu Glu Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu 3560 3565 3570 Glu Ser Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro Gln 3575 3580 3585 Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr 3590 3595 3600 Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val 3605 3610 3615 Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu 3620 3625 3630 Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu 3635 3640 3645 Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly His Asn Val Gly 3650 3655 3660 Ser Leu Phe His Met Ala Asp Asp Leu Gly Arg Ala Met Glu Ser 3665 3670 3675 Leu Val Ser Val Met Thr Asp Glu Glu Gly Ala Glu 3680 3685 3690 <210> 54 <211> 13055 <212> DNA <213> Homo sapiens <400> 54 actttccccc tacaggactc agatctggga ggcaattacc ttcggagaaa aacgaatagg 60 aaaaactgaa gtgttacttt ttttaaagct gctgaagttt gttggtttct cattgttttt 120 aagcctactg gagcaataaa gtttgaagaa cttttaccag gtttttttta tcgctgcctt 180 gatatacact tttcaaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag 240 atgttcaaaa gaaaacattc acaaaatggg taaatgcaca attttctaag tttgggaagc 300 agcatattga gaacctcttc agtgacctac aggatgggag gcgcctccta gacctcctcg 360 aaggcctgac agggcaaaaa ctgccaaaag aaaaaggatc cacaagagtt catgccctga 420 acaatgtcaa caaggcactg cgggttttgc agaacaataa tgttgattta gtgaatattg 480 gaagtactga catcgtagat ggaaatcata aactgactct tggtttgatt tggaatataa 540 tcctccactg gcaggtcaaa aatgtaatga aaaatatcat ggctggattg caacaaacca 600 acagtgaaaa gattctcctg agctgggtcc gacaatcaac tcgtaattat ccacaggtta 660 atgtaatcaa cttcaccacc agctggtctg atggcctggc tttgaatgct ctcatccata 720 gtcataggcc agacctattt gactggaata gtgtggtttg ccagcagtca gccacacaac 780 gactggaaca tgcattcaac atcgccagat atcaattagg catagagaaa ctactcgatc 840 ctgaagatgt tgataccacc tatccagata agaagtccat cttaatgtac atcacatcac 900 tcttccaagt tttgcctcaa caagtgagca ttgaagccat ccaggaagtg gaaatgttgc 960 caaggccacc taaagtgact aaagaagaac attttcagtt acatcatcaa atgcactatt 1020 ctcaacagat cacggtcagt ctagcacagg gatatgagag aacttcttcc cctaagcctc 1080 gattcaagag ctatgcctac acacaggctg cttatgtcac cacctctgac cctacacgga 1140 gcccatttcc ttcacagcat ttggaagctc ctgaagacaa gtcatttggc agttcattga 1200 tggagagtga agtaaacctg gaccgttatc aaacagcttt agaagaagta ttatcgtggc 1260 ttctttctgc tgaggacaca ttgcaagcac aaggagagat ttctaatgat gtggaagtgg 1320 tgaaagacca gtttcatact catgaggggt acatgatgga tttgacagcc catcagggcc 1380 gggttggtaa tattctacaa ttgggaagta agctgattgg aacaggaaaa ttatcagaag 1440 atgaagaaac tgaagtacaa gagcagatga atctcctaaa ttcaagatgg gaatgcctca 1500 gggtagctag catggaaaaa caaagcaatt tacatagagt tttaatggat ctccagaatc 1560 agaaactgaa agagttgaat gactggctaa caaaaacaga agaaagaaca aggaaaatgg 1620 aggaagagcc tcttggacct gatcttgaag acctaaaacg ccaagtacaa caacataagg 1680 tgcttcaaga agatctagaa caagaacaag tcagggtcaa ttctctcact cacatggtgg 1740 tggtagttga tgaatctagt ggagatcacg caactgctgc tttggaagaa caacttaagg 1800 tattgggaga tcgatgggca aacatctgta gatggacaga agaccgctgg gttcttttac 1860 aagacatcct tctcaaatgg caacgtctta ctgaagaaca gtgccttttt agtgcatggc 1920 tttcagaaaa agaagatgca gtgaacaaga ttcacacaac tggctttaaa gatcaaaatg 1980 aaatgttatc aagtcttcaa aaactggccg ttttaaaagc ggatctagaa aagaaaaagc 2040 aatccatggg caaactgtat tcactcaaac aagatcttct ttcaacactg aagaataagt 2100 cagtgaccca gaagacggaa gcatggctgg ataactttgc ccggtgttgg gataatttag 2160 tccaaaaact tgaaaagagt acagcacaga tttcacaggc tgtcaccacc actcagccat 2220 cactaacaca gacaactgta atggaaacag taactacggt gaccacaagg gaacagatcc 2280 tggtaaagca tgctcaagag gaacttccac caccacctcc ccaaaagaag aggcagatta 2340 ctgtggattc tgaaattagg aaaaggttgg atgttgatat aactgaactt cacagctgga 2400 ttactcgctc agaagctgtg ttgcagagtc ctgaatttgc aatctttcgg aaggaaggca 2460 acttctcaga cttaaaagaa aaagtcaatg ccatagagcg agaaaaagct gagaagttca 2520 gaaaactgca agatgccagc agatcagctc aggccctggt ggaacagatg gtgaatgagg 2580 gtgttaatgc agatagcatc aaacaagcct cagaacaact gaacagccgg tggatcgaat 2640 tctgccagtt gctaagtgag agacttaact ggctggagta tcagaacaac atcatcgctt 2700 tctataatca gctacaacaa ttggagcaga tgacaactac tgctgaaaac tggttgaaaa 2760 tccaacccac caccccatca gagccaacag caattaaaag tcagttaaaa atttgtaagg 2820 atgaagtcaa ccggctatca gatcttcaac ctcaaattga acgattaaaa attcaaagca 2880 tagccctgaa agagaaagga caaggaccca tgttcctgga tgcagacttt gtggccttta 2940 caaatcattt taagcaagtc ttttctgatg tgcaggccag agagaaagag ctacagacaa 3000 tttttgacac tttgccacca atgcgctatc aggagaccat gagtgccatc aggacatggg 3060 tccagcagtc agaaaccaaa ctctccatac ctcaacttag tgtcaccgac tatgaaatca 3120 tggagcagag actcggggaa ttgcaggctt tacaaagttc tctgcaagag caacaaagtg 3180 gcctatacta tctcagcacc actgtgaaag agatgtcgaa gaaagcgccc tctgaaatta 3240 gccggaaata tcaatcagaa tttgaagaaa ttgagggacg ctggaagaag ctctcctccc 3300 agctggttga gcattgtcaa aagctagagg agcaaatgaa taaactccga aaaattcaga 3360 atcacataca aaccctgaag aaatggatgg ctgaagttga tgtttttctg aaggaggaat 3420 ggcctgccct tggggattca gaaattctaa aaaagcagct gaaacagtgc agacttttag 3480 tcagtgatat tcagacaatt cagcccagtc taaacagtgt caatgaaggt gggcagaaga 3540 taaagaatga agcagagcca gagtttgctt cgagacttga gacagaactc aaagaactta 3600 acactcagtg ggatcacatg tgccaacagg tctatgccag aaaggaggcc ttgaagggag 3660 gtttggagaa aactgtaagc ctccagaaag atctatcaga gatgcacgaa tggatgacac 3720 aagctgaaga agagtatctt gagagagatt ttgaatataa aactccagat gaattacaga 3780 aagcagttga agagatgaag agagctaaag aagaggccca acaaaaagaa gcgaaagtga 3840 aactccttac tgagtctgta aatagtgtca tagctcaagc tccacctgta gcacaagagg 3900 ccttaaaaaa ggaacttgaa actctaacca ccaactacca gtggctctgc actaggctga 3960 atgggaaatg caagactttg gaagaagttt gggcatgttg gcatgagtta ttgtcatact 4020 tggagaaagc aaacaagtgg ctaaatgaag tagaatttaa acttaaaacc actgaaaaca 4080 ttcctggcgg agctgaggaa atctctgagg tgctagattc acttgaaaat ttgatgcgac 4140 attcagagga taacccaaat cagattcgca tattggcaca gaccctaaca gatggcggag 4200 tcatggatga gctaatcaat gaggaacttg agacatttaa ttctcgttgg agggaactac 4260 atgaagaggc tgtaaggagg caaaagttgc ttgaacagag catccagtct gcccaggaga 4320 ctgaaaaatc cttacactta atccaggagt ccctcacatt cattgacaag cagttggcag 4380 cttatattgc agacaaggtg gacgcagctc aaatgcctca ggaagcccag aaaatccaat 4440 ctgatttgac aagtcatgag atcagtttag aagaaatgaa gaaacataat caggggaagg 4500 aggctgccca aagagtcctg tctcagattg atgttgcaca gaaaaaatta caagatgtct 4560 ccatgaagtt tcgattattc cagaaaccag ccaattttga gcagcgtcta caagaaagta 4620 agatgatttt agatgaagtg aagatgcact tgcctgcatt ggaaacaaag agtgtggaac 4680 aggaagtagt acagtcacag ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag 4740 tgaagtctga agtggaaatg gtgataaaga ctggacgtca gattgtacag aaaaagcaga 4800 cggaaaatcc caaagaactt gatgaaagag taacagcttt gaaattgcat tataatgagc 4860 tgggagcaaa ggtaacagaa agaaagcaac agttggagaa atgcttgaaa ttgtcccgta 4920 agatgcgaaa ggaaatgaat gtcttgacag aatggctggc agctacagat atggaattga 4980 caaagagatc agcagttgaa ggaatgccta gtaatttgga ttctgaagtt gcctggggaa 5040 aggctactca aaaagagatt gagaaacaga aggtgcacct gaagagtatc acagaggtag 5100 gagaggcctt gaaaacagtt ttgggcaaga aggagacgtt ggtggaagat aaactcagtc 5160 ttctgaatag taactggata gctgtcacct cccgagcaga agagtggtta aatcttttgt 5220 tggaatacca gaaacacatg gaaacttttg accagaatgt ggaccacatc acaaagtgga 5280 tcattcaggc tgacacactt ttggatgaat cagagaaaaa gaaaccccag caaaaagaag 5340 acgtgcttaa gcgtttaaag gcagaactga atgacatacg cccaaaggtg gactctacac 5400 gtgaccaagc agcaaacttg atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc 5460 cccaaatctc agagctcaac catcgatttg cagccatttc acacagaatt aagactggaa 5520 aggcctccat tcctttgaag gaattggagc agtttaactc agatatacaa aaattgcttg 5580 aaccactgga ggctgaaatt cagcaggggg tgaatctgaa agaggaagac ttcaataaag 5640 atatgaatga agacaatgag ggtactgtaa aagaattgtt gcaaagagga gacaacttac 5700 aacaaagaat cacagatgag agaaagcgag aggaaataaa gataaaacag cagctgttac 5760 agacaaaaca taatgctctc aaggatttga ggtctcaaag aagaaaaaag gctctagaaa 5820 tttctcatca gtggtatcag tacaagaggc aggctgatga tctcctgaaa tgcttggatg 5880 acattgaaaa aaaattagcc agcctacctg agcccagaga tgaaaggaaa ataaaggaaa 5940 ttgatcggga attgcagaag aagaaagagg agctgaatgc agtgcgtagg caagctgagg 6000 gcttgtctga ggatggggcc gcaatggcag tggagccaac tcagatccag ctcagcaagc 6060 gctggcggga aattgagagc aaatttgctc agtttcgaag actcaacttt gcacaaattc 6120 acactgtccg tgaagaaacg atgatggtga tgactgaaga catgcctttg gaaatttctt 6180 atgtgccttc tacttatttg actgaaatca ctcatgtctc acaagcccta ttagaagtgg 6240 aacaacttct caatgctcct gacctctgtg ctaaggactt tgaagatctc tttaagcaag 6300 aggagtctct gaagaatata aaagatagtc tacaacaaag ctcaggtcgg attgacatta 6360 ttcatagcaa gaagacagca gcattgcaaa gtgcaacgcc tgtggaaagg gtgaagctac 6420 aggaagctct ctcccagctt gatttccaat gggaaaaagt taacaaaatg tacaaggacc 6480 gacaagggcg atttgacaga tctgttgaga aatggcggcg ttttcattat gatataaaga 6540 tatttaatca gtggctaaca gaagctgaac agtttctcag aaagacacaa attcctgaga 6600 attgggaaca tgctaaatac aaatggtatc ttaaggaact ccaggatggc attgggcagc 6660 ggcaaactgt tgtcagaaca ttgaatgcaa ctggggaaga aataattcag caatcctcaa 6720 aaacagatgc cagtattcta caggaaaaat tgggaagcct gaatctgcgg tggcaggagg 6780 tctgcaaaca gctgtcagac agaaaaaaga ggctagaaga acaaaagaat atcttgtcag 6840 aatttcaaag agatttaaat gaatttgttt tatggttgga ggaagcagat aacattgcta 6900 gtatcccact tgaacctgga aaagagcagc aactaaaaga aaagcttgag caagtcaagt 6960 tactggtgga agagttgccc ctgcgccagg gaattctcaa acaattaaat gaaactggag 7020 gacccgtgct tgtaagtgct cccataagcc cagaagagca agataaactt gaaaataagc 7080 tcaagcagac aaatctccag tggataaagg tttccagagc tttacctgag aaacaaggag 7140 aaattgaagc tcaaataaaa gaccttgggc agcttgaaaa aaagcttgaa gaccttgaag 7200 agcagttaaa tcatctgctg ctgtggttat ctcctattag gaatcagttg gaaatttata 7260 accaaccaaa ccaagaagga ccatttgacg ttaaggaaac tgaaatagca gttcaagcta 7320 aacaaccgga tgtggaagag attttgtcta aagggcagca tttgtacaag gaaaaaccag 7380 ccactcagcc agtgaagagg aagttagaag atctgagctc tgagtggaag gcggtaaacc 7440 gtttacttca agagctgagg gcaaagcagc ctgacctagc tcctggactg accactattg 7500 gagcctctcc tactcagact gttactctgg tgacacaacc tgtggttact aaggaaactg 7560 ccatctccaa actagaaatg ccatcttcct tgatgttgga ggtacctgct ctggcagatt 7620 tcaaccgggc ttggacagaa cttaccgact ggctttctct gcttgatcaa gttataaaat 7680 cacagagggt gatggtgggt gaccttgagg atatcaacga gatgatcatc aagcagaagg 7740 caacaatgca ggatttggaa cagaggcgtc cccagttgga agaactcatt accgctgccc 7800 aaaatttgaa aaacaagacc agcaatcaag aggctagaac aatcattacg gatcgaattg 7860 aaagaattca gaatcagtgg gatgaagtac aagaacacct tcagaaccgg aggcaacagt 7920 tgaatgaaat gttaaaggat tcaacacaat ggctggaagc taaggaagaa gctgagcagg 7980 tcttaggaca ggccagagcc aagcttgagt catggaagga gggtccctat acagtagatg 8040 caatccaaaa gaaaatcaca gaaaccaagc agttggccaa agacctccgc cagtggcaga 8100 caaatgtaga tgtggcaaat gacttggccc tgaaacttct ccgggattat tctgcagatg 8160 ataccagaaa agtccacatg ataacagaga atatcaatgc ctcttggaga agcattcata 8220 aaagggtgag tgagcgagag gctgctttgg aagaaactca tagattactg caacagttcc 8280 ccctggacct ggaaaagttt cttgcctggc ttacagaagc tgaaacaact gccaatgtcc 8340 tacaggatgc tacccgtaag gaaaggctcc tagaagactc caagggagta aaagagctga 8400 tgaaacaatg gcaagacctc caaggtgaaa ttgaagctca cacagatgtt tatcacaacc 8460 tggatgaaaa cagccaaaaa atcctgagat ccctggaagg ttccgatgat gcagtcctgt 8520 tacaaagacg tttggataac atgaacttca agtggagtga acttcggaaa aagtctctca 8580 acattaggtc ccatttggaa gccagttctg accagtggaa gcgtctgcac ctttctctgc 8640 aggaacttct ggtgtggcta cagctgaaag atgatgaatt aagccggcag gcacctattg 8700 gaggcgactt tccagcagtt cagaagcaga acgatgtaca tagggccttc aagagggaat 8760 tgaaaactaa agaacctgta atcatgagta ctcttgagac tgtacgaata tttctgacag 8820 agcagccttt ggaaggacta gagaaactct accaggagcc cagagagctg cctcctgagg 8880 agagagccca gaatgtcact cggcttctac gaaagcaggc tgaggaggtc aatactgagt 8940 gggaaaaatt gaacctgcac tccgctgact ggcagagaaa aatagatgag acccttgaaa 9000 gactccggga acttcaagag gccacggatg agctggacct caagctgcgc caagctgagg 9060 tgatcaaggg atcctggcag cccgtgggcg atctcctcat tgactctctc caagatcacc 9120 tcgagaaagt caaggcactt cgaggagaaa ttgcgcctct gaaagagaac gtgagccacg 9180 tcaatgacct tgctcgccag cttaccactt tgggcattca gctctcaccg tataacctca 9240 gcactctgga agacctgaac accagatgga agcttctgca ggtggccgtc gaggaccgag 9300 tcaggcagct gcatgaagcc cacagggact ttggtccagc atctcagcac tttctttcca 9360 cgtctgtcca gggtccctgg gagagagcca tctcgccaaa caaagtgccc tactatatca 9420 accacgagac tcaaacaact tgctgggacc atcccaaaat gacagagctc taccagtctt 9480 tagctgacct gaataatgtc agattctcag cttataggac tgccatgaaa ctccgaagac 9540 tgcagaaggc cctttgcttg gatctcttga gcctgtcagc tgcatgtgat gccttggacc 9600 agcacaacct caagcaaaat gaccagccca tggatatcct gcagattatt aattgtttga 9660 ccactattta tgaccgcctg gagcaagagc acaacaattt ggtcaacgtc cctctctgcg 9720 tggatatgtg tctgaactgg ctgctgaatg tttatgatac gggacgaaca gggaggatcc 9780 gtgtcctgtc ttttaaaact ggcatcattt ccctgtgtaa agcacatttg gaagacaagt 9840 acagatacct tttcaagcaa gtggcaagtt caacaggatt ttgtgaccag cgcaggctgg 9900 gcctccttct gcatgattct atccaaattc caagacagtt gggtgaagtt gcatcctttg 9960 ggggcagtaa cattgagcca agtgtccgga gctgcttcca atttgctaat aataagccag 10020 agatcgaagc ggccctcttc ctagactgga tgagactgga accccagtcc atggtgtggc 10080 tgcccgtcct gcacagagtg gctgctgcag aaactgccaa gcatcaggcc aaatgtaaca 10140 tctgcaaaga gtgtccaatc attggattca ggtacaggag tctaaagcac tttaattatg 10200 acatctgcca aagctgcttt ttttctggtc gagttgcaaa aggccataaa atgcactatc 10260 ccatggtgga atattgcact ccgactacat caggagaaga tgttcgagac tttgccaagg 10320 tactaaaaaa caaatttcga accaaaaggt attttgcgaa gcatccccga atgggctacc 10380 tgccagtgca gactgtctta gagggggaca acatggaaac gaatctgcaa gcagaatatg 10440 accgtctaaa gcagcagcac gaacataaag gcctgtcccc actgccgtcc cctcctgaaa 10500 tgatgcccac ctctccccag agtccccggg atgctgagct cattgctgag gccaagctac 10560 tgcgtcaaca caaaggccgc ctggaagcca ggatgcaaat cctggaagac cacaataaac 10620 agctggagtc acagttacac aggctaaggc agctgctgga gcaaccccag gcagaggcca 10680 aagtgaatgg cacaacggtg tcctctcctt ctacctctct acagaggtcc gacagcagtc 10740 agcctatgct gctccgagtg gttggcagtc aaacttcgga ctccatgggt gaggaagatc 10800 ttctcagtcc tccccaggac acaagcacag ggttagagga ggtgatggag caactcaaca 10860 actccttccc tagttcaaga ggacacaatg taggaagtct tttccacatg gcagatgatt 10920 tgggcagagc gatggagtcc ttagtatcag tcatgacaga tgaagaagga gcagaataaa 10980 tgttttacaa ctcctgattc ccgcatggtt tttataatat tcatacaaca aagaggatta 11040 gacagtaaga gtttacaaga aataaatcta tatttttgtg aagggtagtg gtattatact 11100 gtagatttca gtagtttcta agtctgttat tgttttgtta acaatggcag gttttacacg 11160 tctatgcaat tgtacaaaaa agttataaga aaactacatg taaaatcttg atagctaaat 11220 aacttgccat ttctttatat ggaacgcatt ttgggttgtt taaaaattta taacagttat 11280 aaagaaagat tgtaaactaa agtgtgcttt ataaaaaaaa gttgtttata aaaaccccta 11340 aaaacaaaac aaacacacac acacacacat acacacacac acacaaaact ttgaggcagc 11400 gcattgtttt gcatcctttt ggcgtgatat ccatatgaaa ttcatggctt tttctttttt 11460 tgcatattaa agataagact tcctctacca ccacaccaaa tgactactac acactgctca 11520 tttgagaact gtcagctgag tggggcaggc ttgagttttc atttcatata tctatatgtc 11580 tataagtata taaatactat agttatatag ataaagagat acgaatttct atagactgac 11640 tttttccatt ttttaaatgt tcatgtcaca tcctaataga aagaaattac ttctagtcag 11700 tcatccaggc ttacctgctt ggtctagaat ggatttttcc cggagccgga agccaggagg 11760 aaactacacc acactaaaac attgtctaca gctccagatg tttctcattt taaacaactt 11820 tccactgaca acgaaagtaa agtaaagtat tggatttttt taaagggaac atgtgaatga 11880 atacacagga cttattatat cagagtgagt aatcggttgg ttggttgatt gattgattga 11940 ttgatacatt cagcttcctg ctgctagcaa tgccacgatt tagatttaat gatgcttcag 12000 tggaaatcaa tcagaaggta ttctgacctt gtgaacatca gaaggtattt tttaactccc 12060 aagcagtagc aggacgatga tagggctgga gggctatgga ttcccagccc atccctgtga 12120 aggagtaggc cactctttaa gtgaaggatt ggatgattgt tcataataca taaagttctc 12180 tgtaattaca actaaattat tatgccctct tctcacagtc aaaaggaact gggtggtttg 12240 gtttttgttg cttttttaga tttattgtcc catgtgggat gagtttttaa atgccacaag 12300 acataattta aaataaataa actttgggaa aaggtgtaaa acagtagccc catcacattt 12360 gtgatactga caggtatcaa cccagaagcc catgaactgt gtttccatcc tttgcatttc 12420 tctgcgagta gttccacaca ggtttgtaag taagtaagaa agaaggcaaa ttgattcaaa 12480 tgttacaaaa aaacccttct tggtggatta gacaggttaa atatataaac aaacaaacaa 12540 aaattgctca aaaaagagga gaaaagctca agaggaaaag ctaaggactg gtaggaaaaa 12600 gctttactct ttcatgccat tttatttctt tttgattttt aaatcattca ttcaatagat 12660 accaccgtgt gacctataat tttgcaaatc tgttacctct gacatcaagt gtaattagct 12720 tttggagagt gggctgacat caagtgtaat tagcttttgg agagtgggtt ttgtccatta 12780 ttaataatta attaattaac atcaaacacg gcttctcatg ctatttctac ctcactttgg 12840 ttttggggtg ttcctgataa ttgtgcacac ctgagttcac agcttcacca cttgtccatt 12900 gcgttatttt ctttttcctt tataattctt tctttttcct tcataatttt caaaagaaaa 12960 cccaaagctc taaggtaaca aattaccaaa ttacatgaag atttggtttt tgtcttgcat 13020 ttttttcctt tatgtgacgc tggacctttt cttta 13055 <210> 55 <211> 3593 <212> PRT <213> Homo sapiens <400> 55 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser 1775 1780 1785 Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln 1790 1795 1800 Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu 1805 1810 1815 Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn 1820 1825 1830 Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys 1835 1840 1845 Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp 1850 1855 1860 Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln 1865 1870 1875 Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu 1880 1885 1890 Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp 1895 1900 1905 Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys 1910 1915 1920 Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu 1925 1930 1935 Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser 1940 1945 1950 Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg 1955 1960 1965 Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met 1970 1975 1980 Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser 1985 1990 1995 Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu 2000 2005 2010 Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe 2015 2020 2025 Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp 2030 2035 2040 Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys 2045 2050 2055 Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 2060 2065 2070 Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 2075 2080 2085 Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 2090 2095 2100 Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 2105 2110 2115 Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro 2120 2125 2130 Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu 2135 2140 2145 Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 2150 2155 2160 Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala 2165 2170 2175 Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln 2180 2185 2190 Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu 2195 2200 2205 Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe 2210 2215 2220 Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu 2225 2230 2235 Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val 2240 2245 2250 Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys 2255 2260 2265 Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile 2270 2275 2280 Ser Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr 2285 2290 2295 Asn Leu Gln Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln 2300 2305 2310 Gly Glu Ile Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys 2315 2320 2325 Lys Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp 2330 2335 2340 Leu Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn 2345 2350 2355 Gln Glu Gly Pro Phe Asp Val Lys Glu Thr Glu Ile Ala Val Gln 2360 2365 2370 Ala Lys Gln Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His 2375 2380 2385 Leu Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu 2390 2395 2400 Glu Asp Leu Ser Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln 2405 2410 2415 Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr 2420 2425 2430 Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro 2435 2440 2445 Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser 2450 2455 2460 Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala 2465 2470 2475 Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile 2480 2485 2490 Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 2495 2500 2505 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg 2510 2515 2520 Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys 2525 2530 2535 Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg 2540 2545 2550 Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu 2555 2560 2565 Gln Asn Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr 2570 2575 2580 Gln Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln 2585 2590 2595 Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val 2600 2605 2610 Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys 2615 2620 2625 Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu 2630 2635 2640 Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys 2645 2650 2655 Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile 2660 2665 2670 His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His 2675 2680 2685 Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala 2690 2695 2700 Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala 2705 2710 2715 Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu 2720 2725 2730 Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 2735 2740 2745 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu 2750 2755 2760 Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg 2765 2770 2775 Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser 2780 2785 2790 Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys 2795 2800 2805 Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu 2810 2815 2820 Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe 2825 2830 2835 Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg 2840 2845 2850 Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr 2855 2860 2865 Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 2870 2875 2880 Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln 2885 2890 2895 Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr 2900 2905 2910 Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys 2915 2920 2925 Ile Asp Glu Thr Leu Glu Arg Leu Arg Glu Leu Gln Glu Ala Thr 2930 2935 2940 Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly 2945 2950 2955 Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp 2960 2965 2970 His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 2975 2980 2985 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 2990 2995 3000 Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 3005 3010 3015 Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 3020 3025 3030 Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala 3035 3040 3045 Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg 3050 3055 3060 Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 3065 3070 3075 Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln 3080 3085 3090 Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr 3095 3100 3105 Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu 3110 3115 3120 Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu 3125 3130 3135 Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys 3140 3145 3150 Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu 3155 3160 3165 Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu 3170 3175 3180 Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser 3185 3190 3195 Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp 3200 3205 3210 Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 3215 3220 3225 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln 3230 3235 3240 Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn 3245 3250 3255 Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys 3260 3265 3270 Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu 3275 3280 3285 Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala 3290 3295 3300 Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu 3305 3310 3315 Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn 3320 3325 3330 Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys 3335 3340 3345 Gly His Lys Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr 3350 3355 3360 Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn 3365 3370 3375 Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly 3380 3385 3390 Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr 3395 3400 3405 Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His 3410 3415 3420 Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr 3425 3430 3435 Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys 3440 3445 3450 Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile 3455 3460 3465 Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu 3470 3475 3480 Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly 3485 3490 3495 Thr Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser 3500 3505 3510 Ser Gln Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp 3515 3520 3525 Ser Met Gly Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser 3530 3535 3540 Thr Gly Leu Glu Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro 3545 3550 3555 Ser Ser Arg Gly His Asn Val Gly Ser Leu Phe His Met Ala Asp 3560 3565 3570 Asp Leu Gly Arg Ala Met Glu Ser Leu Val Ser Val Met Thr Asp 3575 3580 3585 Glu Glu Gly Ala Glu 3590 <210> 56 <211> 11474 <212> DNA <213> Homo sapiens <400> 56 actttccccc tacaggactc agatctggga ggcaattacc ttcggagaaa aacgaatagg 60 aaaaactgaa gtgttacttt ttttaaagct gctgaagttt gttggtttct cattgttttt 120 aagcctactg gagcaataaa gtttgaagaa cttttaccag gtttttttta tcgctgcctt 180 gatatacact tttcaaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag 240 atgttcaaaa gaaaacattc acaaaatggg taaatgcaca attttctaag tttgggaagc 300 agcatattga gaacctcttc agtgacctac aggatgggag gcgcctccta gacctcctcg 360 aaggcctgac agggcaaaaa ctgccaaaag aaaaaggatc cacaagagtt catgccctga 420 acaatgtcaa caaggcactg cgggttttgc agaacaataa tgttgattta gtgaatattg 480 gaagtactga catcgtagat ggaaatcata aactgactct tggtttgatt tggaatataa 540 tcctccactg gcaggtcaaa aatgtaatga aaaatatcat ggctggattg caacaaacca 600 acagtgaaaa gattctcctg agctgggtcc gacaatcaac tcgtaattat ccacaggtta 660 atgtaatcaa cttcaccacc agctggtctg atggcctggc tttgaatgct ctcatccata 720 gtcataggcc agacctattt gactggaata gtgtggtttg ccagcagtca gccacacaac 780 gactggaaca tgcattcaac atcgccagat atcaattagg catagagaaa ctactcgatc 840 ctgaagatgt tgataccacc tatccagata agaagtccat cttaatgtac atcacatcac 900 tcttccaagt tttgcctcaa caagtgagca ttgaagccat ccaggaagtg gaaatgttgc 960 caaggccacc taaagtgact aaagaagaac attttcagtt acatcatcaa atgcactatt 1020 ctcaacagat cacggtcagt ctagcacagg gatatgagag aacttcttcc cctaagcctc 1080 gattcaagag ctatgcctac acacaggctg cttatgtcac cacctctgac cctacacgga 1140 gcccatttcc ttcacagcat ttggaagctc ctgaagacaa gtcatttggc agttcattga 1200 tggagagtga agtaaacctg gaccgttatc aaacagcttt agaagaagta ttatcgtggc 1260 ttctttctgc tgaggacaca ttgcaagcac aaggagagat ttctaatgat gtggaagtgg 1320 tgaaagacca gtttcatact catgaggggt acatgatgga tttgacagcc catcagggcc 1380 gggttggtaa tattctacaa ttgggaagta agctgattgg aacaggaaaa ttatcagaag 1440 atgaagaaac tgaagtacaa gagcagatga atctcctaaa ttcaagatgg gaatgcctca 1500 gggtagctag catggaaaaa caaagcaatt tacatagagt tttaatggat ctccagaatc 1560 agaaactgaa agagttgaat gactggctaa caaaaacaga agaaagaaca aggaaaatgg 1620 aggaagagcc tcttggacct gatcttgaag acctaaaacg ccaagtacaa caacataagg 1680 tgcttcaaga agatctagaa caagaacaag tcagggtcaa ttctctcact cacatggtgg 1740 tggtagttga tgaatctagt ggagatcacg caactgctgc tttggaagaa caacttaagg 1800 tattgggaga tcgatgggca aacatctgta gatggacaga agaccgctgg gttcttttac 1860 aagacatcct tctcaaatgg caacgtctta ctgaagaaca gtgccttttt agtgcatggc 1920 tttcagaaaa agaagatgca gtgaacaaga ttcacacaac tggctttaaa gatcaaaatg 1980 aaatgttatc aagtcttcaa aaactggccg ttttaaaagc ggatctagaa aagaaaaagc 2040 aatccatggg caaactgtat tcactcaaac aagatcttct ttcaacactg aagaataagt 2100 cagtgaccca gaagacggaa gcatggctgg ataactttgc ccggtgttgg gataatttag 2160 tccaaaaact tgaaaagagt acagcacaga tttcacaggc tgtcaccacc actcagccat 2220 cactaacaca gacaactgta atggaaacag taactacggt gaccacaagg gaacagatcc 2280 tggtaaagca tgctcaagag gaacttccac caccacctcc ccaaaagaag aggcagatta 2340 ctgtggattc tgaaattagg aaaaggttgg atgttgatat aactgaactt cacagctgga 2400 ttactcgctc agaagctgtg ttgcagagtc ctgaatttgc aatctttcgg aaggaaggca 2460 acttctcaga cttaaaagaa aaagtcaatg ccatagagcg agaaaaagct gagaagttca 2520 gaaaactgca agatgccagc agatcagctc aggccctggt ggaacagatg gtgaatgagg 2580 gtgttaatgc agatagcatc aaacaagcct cagaacaact gaacagccgg tggatcgaat 2640 tctgccagtt gctaagtgag agacttaact ggctggagta tcagaacaac atcatcgctt 2700 tctataatca gctacaacaa ttggagcaga tgacaactac tgctgaaaac tggttgaaaa 2760 tccaacccac caccccatca gagccaacag caattaaaag tcagttaaaa atttgtaagg 2820 atgaagtcaa ccggctatca gatcttcaac ctcaaattga acgattaaaa attcaaagca 2880 tagccctgaa agagaaagga caaggaccca tgttcctgga tgcagacttt gtggccttta 2940 caaatcattt taagcaagtc ttttctgatg tgcaggccag agagaaagag ctacagacaa 3000 tttttgacac tttgccacca atgcgctatc aggagaccat gagtgccatc aggacatggg 3060 tccagcagtc agaaaccaaa ctctccatac ctcaacttag tgtcaccgac tatgaaatca 3120 tggagcagag actcggggaa ttgcaggctt tacaaagttc tctgcaagag caacaaagtg 3180 gcctatacta tctcagcacc actgtgaaag agatgtcgaa gaaagcgccc tctgaaatta 3240 gccggaaata tcaatcagaa tttgaagaaa ttgagggacg ctggaagaag ctctcctccc 3300 agctggttga gcattgtcaa aagctagagg agcaaatgaa taaactccga aaaattcaga 3360 atcacataca aaccctgaag aaatggatgg ctgaagttga tgtttttctg aaggaggaat 3420 ggcctgccct tggggattca gaaattctaa aaaagcagct gaaacagtgc agacttttag 3480 tcagtgatat tcagacaatt cagcccagtc taaacagtgt caatgaaggt gggcagaaga 3540 taaagaatga agcagagcca gagtttgctt cgagacttga gacagaactc aaagaactta 3600 acactcagtg ggatcacatg tgccaacagg tctatgccag aaaggaggcc ttgaagggag 3660 gtttggagaa aactgtaagc ctccagaaag atctatcaga gatgcacgaa tggatgacac 3720 aagctgaaga agagtatctt gagagagatt ttgaatataa aactccagat gaattacaga 3780 aagcagttga agagatgaag agagctaaag aagaggccca acaaaaagaa gcgaaagtga 3840 aactccttac tgagtctgta aatagtgtca tagctcaagc tccacctgta gcacaagagg 3900 ccttaaaaaa ggaacttgaa actctaacca ccaactacca gtggctctgc actaggctga 3960 atgggaaatg caagactttg gaagaagttt gggcatgttg gcatgagtta ttgtcatact 4020 tggagaaagc aaacaagtgg ctaaatgaag tagaatttaa acttaaaacc actgaaaaca 4080 ttcctggcgg agctgaggaa atctctgagg tgctagattc acttgaaaat ttgatgcgac 4140 attcagagga taacccaaat cagattcgca tattggcaca gaccctaaca gatggcggag 4200 tcatggatga gctaatcaat gaggaacttg agacatttaa ttctcgttgg agggaactac 4260 atgaagaggc tgtaaggagg caaaagttgc ttgaacagag catccagtct gcccaggaga 4320 ctgaaaaatc cttacactta atccaggagt ccctcacatt cattgacaag cagttggcag 4380 cttatattgc agacaaggtg gacgcagctc aaatgcctca ggaagcccag aaaatccaat 4440 ctgatttgac aagtcatgag atcagtttag aagaaatgaa gaaacataat caggggaagg 4500 aggctgccca aagagtcctg tctcagattg atgttgcaca gaaaaaatta caagatgtct 4560 ccatgaagtt tcgattattc cagaaaccag ccaattttga gcagcgtcta caagaaagta 4620 agatgatttt agatgaagtg aagatgcact tgcctgcatt ggaaacaaag agtgtggaac 4680 aggaagtagt acagtcacag ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag 4740 tgaagtctga agtggaaatg gtgataaaga ctggacgtca gattgtacag aaaaagcaga 4800 cggaaaatcc caaagaactt gatgaaagag taacagcttt gaaattgcat tataatgagc 4860 tgggagcaaa ggtaacagaa agaaagcaac agttggagaa atgcttgaaa ttgtcccgta 4920 agatgcgaaa ggaaatgaat gtcttgacag aatggctggc agctacagat atggaattga 4980 caaagagatc agcagttgaa ggaatgccta gtaatttgga ttctgaagtt gcctggggaa 5040 aggctactca aaaagagatt gagaaacaga aggtgcacct gaagagtatc acagaggtag 5100 gagaggcctt gaaaacagtt ttgggcaaga aggagacgtt ggtggaagat aaactcagtc 5160 ttctgaatag taactggata gctgtcacct cccgagcaga agagtggtta aatcttttgt 5220 tggaatacca gaaacacatg gaaacttttg accagaatgt ggaccacatc acaaagtgga 5280 tcattcaggc tgacacactt ttggatgaat cagagaaaaa gaaaccccag caaaaagaag 5340 acgtgcttaa gcgtttaaag gcagaactga atgacatacg cccaaaggtg gactctacac 5400 gtgaccaagc agcaaacttg atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc 5460 cccaaatctc agagctcaac catcgatttg cagccatttc acacagaatt aagactggaa 5520 aggcctccat tcctttgaag gaattggagc agtttaactc agatatacaa aaattgcttg 5580 aaccactgga ggctgaaatt cagcaggggg tgaatctgaa agaggaagac ttcaataaag 5640 atatgaatga agacaatgag ggtactgtaa aagaattgtt gcaaagagga gacaacttac 5700 aacaaagaat cacagatgag agaaagcgag aggaaataaa gataaaacag cagctgttac 5760 agacaaaaca taatgctctc aaggatttga ggtctcaaag aagaaaaaag gctctagaaa 5820 tttctcatca gtggtatcag tacaagaggc aggctgatga tctcctgaaa tgcttggatg 5880 acattgaaaa aaaattagcc agcctacctg agcccagaga tgaaaggaaa ataaaggaaa 5940 ttgatcggga attgcagaag aagaaagagg agctgaatgc agtgcgtagg caagctgagg 6000 gcttgtctga ggatggggcc gcaatggcag tggagccaac tcagatccag ctcagcaagc 6060 gctggcggga aattgagagc aaatttgctc agtttcgaag actcaacttt gcacaaattc 6120 acactgtccg tgaagaaacg atgatggtga tgactgaaga catgcctttg gaaatttctt 6180 atgtgccttc tacttatttg actgaaatca ctcatgtctc acaagcccta ttagaagtgg 6240 aacaacttct caatgctcct gacctctgtg ctaaggactt tgaagatctc tttaagcaag 6300 aggagtctct gaagaatata aaagatagtc tacaacaaag ctcaggtcgg attgacatta 6360 ttcatagcaa gaagacagca gcattgcaaa gtgcaacgcc tgtggaaagg gtgaagctac 6420 aggaagctct ctcccagctt gatttccaat gggaaaaagt taacaaaatg tacaaggacc 6480 gacaagggcg atttgacaga tctgttgaga aatggcggcg ttttcattat gatataaaga 6540 tatttaatca gtggctaaca gaagctgaac agtttctcag aaagacacaa attcctgaga 6600 attgggaaca tgctaaatac aaatggtatc ttaaggaact ccaggatggc attgggcagc 6660 ggcaaactgt tgtcagaaca ttgaatgcaa ctggggaaga aataattcag caatcctcaa 6720 aaacagatgc cagtattcta caggaaaaat tgggaagcct gaatctgcgg tggcaggagg 6780 tctgcaaaca gctgtcagac agaaaaaaga ggctagaaga acaaaagaat atcttgtcag 6840 aatttcaaag agatttaaat gaatttgttt tatggttgga ggaagcagat aacattgcta 6900 gtatcccact tgaacctgga aaagagcagc aactaaaaga aaagcttgag caagtcaagt 6960 tactggtgga agagttgccc ctgcgccagg gaattctcaa acaattaaat gaaactggag 7020 gacccgtgct tgtaagtgct cccataagcc cagaagagca agataaactt gaaaataagc 7080 tcaagcagac aaatctccag tggataaagg tttccagagc tttacctgag aaacaaggag 7140 aaattgaagc tcaaataaaa gaccttgggc agcttgaaaa aaagcttgaa gaccttgaag 7200 agcagttaaa tcatctgctg ctgtggttat ctcctattag gaatcagttg gaaatttata 7260 accaaccaaa ccaagaagga ccatttgacg ttaaggaaac tgaaatagca gttcaagcta 7320 aacaaccgga tgtggaagag attttgtcta aagggcagca tttgtacaag gaaaaaccag 7380 ccactcagcc agtgaagagg aagttagaag atctgagctc tgagtggaag gcggtaaacc 7440 gtttacttca agagctgagg gcaaagcagc ctgacctagc tcctggactg accactattg 7500 gagcctctcc tactcagact gttactctgg tgacacaacc tgtggttact aaggaaactg 7560 ccatctccaa actagaaatg ccatcttcct tgatgttgga ggtacctgct ctggcagatt 7620 tcaaccgggc ttggacagaa cttaccgact ggctttctct gcttgatcaa gttataaaat 7680 cacagagggt gatggtgggt gaccttgagg atatcaacga gatgatcatc aagcagaagg 7740 caacaatgca ggatttggaa cagaggcgtc cccagttgga agaactcatt accgctgccc 7800 aaaatttgaa aaacaagacc agcaatcaag aggctagaac aatcattacg gatcgaattg 7860 aaagaattca gaatcagtgg gatgaagtac aagaacacct tcagaaccgg aggcaacagt 7920 tgaatgaaat gttaaaggat tcaacacaat ggctggaagc taaggaagaa gctgagcagg 7980 tcttaggaca ggccagagcc aagcttgagt catggaagga gggtccctat acagtagatg 8040 caatccaaaa gaaaatcaca gaaaccaagc agttggccaa agacctccgc cagtggcaga 8100 caaatgtaga tgtggcaaat gacttggccc tgaaacttct ccgggattat tctgcagatg 8160 ataccagaaa agtccacatg ataacagaga atatcaatgc ctcttggaga agcattcata 8220 aaagggtgag tgagcgagag gctgctttgg aagaaactca tagattactg caacagttcc 8280 ccctggacct ggaaaagttt cttgcctggc ttacagaagc tgaaacaact gccaatgtcc 8340 tacaggatgc tacccgtaag gaaaggctcc tagaagactc caagggagta aaagagctga 8400 tgaaacaatg gcaagacctc caaggtgaaa ttgaagctca cacagatgtt tatcacaacc 8460 tggatgaaaa cagccaaaaa atcctgagat ccctggaagg ttccgatgat gcagtcctgt 8520 tacaaagacg tttggataac atgaacttca agtggagtga acttcggaaa aagtctctca 8580 acattaggtc ccatttggaa gccagttctg accagtggaa gcgtctgcac ctttctctgc 8640 aggaacttct ggtgtggcta cagctgaaag atgatgaatt aagccggcag gcacctattg 8700 gaggcgactt tccagcagtt cagaagcaga acgatgtaca tagggccttc aagagggaat 8760 tgaaaactaa agaacctgta atcatgagta ctcttgagac tgtacgaata tttctgacag 8820 agcagccttt ggaaggacta gagaaactct accaggagcc cagagagctg cctcctgagg 8880 agagagccca gaatgtcact cggcttctac gaaagcaggc tgaggaggtc aatactgagt 8940 gggaaaaatt gaacctgcac tccgctgact ggcagagaaa aatagatgag acccttgaaa 9000 gactccggga acttcaagag gccacggatg agctggacct caagctgcgc caagctgagg 9060 tgatcaaggg atcctggcag cccgtgggcg atctcctcat tgactctctc caagatcacc 9120 tcgagaaagt caaggcactt cgaggagaaa ttgcgcctct gaaagagaac gtgagccacg 9180 tcaatgacct tgctcgccag cttaccactt tgggcattca gctctcaccg tataacctca 9240 gcactctgga agacctgaac accagatgga agcttctgca ggtggccgtc gaggaccgag 9300 tcaggcagct gcatgaagcc cacagggact ttggtccagc atctcagcac tttctttcca 9360 cgtctgtcca gggtccctgg gagagagcca tctcgccaaa caaagtgccc tactatatca 9420 accacgagac tcaaacaact tgctgggacc atcccaaaat gacagagctc taccagtctt 9480 tagctgacct gaataatgtc agattctcag cttataggac tgccatgaaa ctccgaagac 9540 tgcagaaggc cctttgcttg gatctcttga gcctgtcagc tgcatgtgat gccttggacc 9600 agcacaacct caagcaaaat gaccagccca tggatatcct gcagattatt aattgtttga 9660 ccactattta tgaccgcctg gagcaagagc acaacaattt ggtcaacgtc cctctctgcg 9720 tggatatgtg tctgaactgg ctgctgaatg tttatgatac gggacgaaca gggaggatcc 9780 gtgtcctgtc ttttaaaact ggcatcattt ccctgtgtaa agcacatttg gaagacaagt 9840 acagatacct tttcaagcaa gtggcaagtt caacaggatt ttgtgaccag cgcaggctgg 9900 gcctccttct gcatgattct atccaaattc caagacagtt gggtgaagtt gcatcctttg 9960 ggggcagtaa cattgagcca agtgtccgga gctgcttcca attttcccaa tctctggaaa 10020 ccacagctct gttttctgtt cctgtaattt tgccttttcc tgaactggat tttaaaggat 10080 tgtaggaggc agtagtggaa gagctaactt tatatcttgt tcttttacat aatgcgccct 10140 gatccacact tgggaaagta tattccatgg tacctataga cagatatatg tgctttacca 10200 tgtatatgtg aaacttttct aatttaactt tcctgttaaa ttagaactcg gtagcataaa 10260 ttaatactgt tgagtatact tagggatttg catagattta aaattgtgca tatgttccct 10320 agggccatgg cgttaattgg tttattagtc aggtggagtg cagagcctga ggtcaggaca 10380 gttgtccttg aacatggaaa tgaagagtgg ataatcacca tgtgttattg tttgggctga 10440 ttttatcttt aatgggtgat tcagagtcct gattaatatt tagagcagtg actgctggcc 10500 tcctacctgc tcattatctt cagaacttta aataaaatac ttgatttcta cccaagatgg 10560 tagttatggg aagcctttta cttcttcttg tctcacaaag acaactcttg acctctcaat 10620 ccttaaacaa aaagttctgc ttctgcgcat gtggggactc ttaaactcat tttcatgcct 10680 ggagattcac atttagggat ctaggaaaag cacatctagg cagagtcgat gaggagatgc 10740 tttaagaacc gtgacaagga caggaaggaa atcaattttg cgttaggttt gtatttttag 10800 agaaaacgaa tcctggggaa cttttcacac tcattactat tgacattaat accattgtcc 10860 tgtccctttc acagttacta aaatcactct tgcccaccct cctgccttgc ccacaaccta 10920 ttcccatgaa ggggtgactt gggagaaata acggtttcca accaacgttt tattttggaa 10980 acatttcaag cacaaagagt agttgaaagg atagtctaaa gaacactcat ctgtgtcata 11040 catctgttca atccatggtt gcttttcgct ctacttacct cctccaccct ctcagctctg 11100 tttatgtatg tgtctgtctg tgtacataca cacacaaaca cattttcccc tatgccattt 11160 aaaagtaaag gagcatcaca acataaaccc ctaaacactt caccatacac cattttctta 11220 aaggatgaca ttctctaaca taactgcaat gctatcgtta cacacaaatt taacagcaat 11280 ccagcaatac cctctgatat gcagtccaca ctgaactttc cccagtgccc cagaattgtt 11340 ccttatagcc actgttttct tccagcatct agtcaaggtt tttgtctgtc atgtctctgt 11400 accttcattt agttttgaac agtctcccag cattttgttt tcctttcatg acattgactt 11460 ttttggtagg ggga 11474 <210> 57 <211> 3295 <212> PRT <213> Homo sapiens <400> 57 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser 1775 1780 1785 Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln 1790 1795 1800 Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu 1805 1810 1815 Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn 1820 1825 1830 Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys 1835 1840 1845 Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp 1850 1855 1860 Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln 1865 1870 1875 Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu 1880 1885 1890 Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp 1895 1900 1905 Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys 1910 1915 1920 Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu 1925 1930 1935 Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser 1940 1945 1950 Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg 1955 1960 1965 Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met 1970 1975 1980 Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser 1985 1990 1995 Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu 2000 2005 2010 Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe 2015 2020 2025 Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp 2030 2035 2040 Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys 2045 2050 2055 Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 2060 2065 2070 Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 2075 2080 2085 Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 2090 2095 2100 Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 2105 2110 2115 Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro 2120 2125 2130 Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu 2135 2140 2145 Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 2150 2155 2160 Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala 2165 2170 2175 Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln 2180 2185 2190 Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu 2195 2200 2205 Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe 2210 2215 2220 Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu 2225 2230 2235 Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val 2240 2245 2250 Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys 2255 2260 2265 Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile 2270 2275 2280 Ser Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr 2285 2290 2295 Asn Leu Gln Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln 2300 2305 2310 Gly Glu Ile Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys 2315 2320 2325 Lys Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp 2330 2335 2340 Leu Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn 2345 2350 2355 Gln Glu Gly Pro Phe Asp Val Lys Glu Thr Glu Ile Ala Val Gln 2360 2365 2370 Ala Lys Gln Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His 2375 2380 2385 Leu Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu 2390 2395 2400 Glu Asp Leu Ser Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln 2405 2410 2415 Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr 2420 2425 2430 Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro 2435 2440 2445 Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser 2450 2455 2460 Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala 2465 2470 2475 Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile 2480 2485 2490 Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu 2495 2500 2505 Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg 2510 2515 2520 Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys 2525 2530 2535 Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg 2540 2545 2550 Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu 2555 2560 2565 Gln Asn Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr 2570 2575 2580 Gln Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln 2585 2590 2595 Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val 2600 2605 2610 Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys 2615 2620 2625 Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu 2630 2635 2640 Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys 2645 2650 2655 Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile 2660 2665 2670 His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His 2675 2680 2685 Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala 2690 2695 2700 Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala 2705 2710 2715 Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu 2720 2725 2730 Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His 2735 2740 2745 Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu 2750 2755 2760 Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg 2765 2770 2775 Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser 2780 2785 2790 Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys 2795 2800 2805 Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu 2810 2815 2820 Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe 2825 2830 2835 Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg 2840 2845 2850 Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr 2855 2860 2865 Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 2870 2875 2880 Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln 2885 2890 2895 Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr 2900 2905 2910 Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys 2915 2920 2925 Ile Asp Glu Thr Leu Glu Arg Leu Arg Glu Leu Gln Glu Ala Thr 2930 2935 2940 Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly 2945 2950 2955 Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp 2960 2965 2970 His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 2975 2980 2985 Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 2990 2995 3000 Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 3005 3010 3015 Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp 3020 3025 3030 Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala 3035 3040 3045 Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg 3050 3055 3060 Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 3065 3070 3075 Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln 3080 3085 3090 Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr 3095 3100 3105 Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu 3110 3115 3120 Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu 3125 3130 3135 Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys 3140 3145 3150 Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu 3155 3160 3165 Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu 3170 3175 3180 Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser 3185 3190 3195 Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp 3200 3205 3210 Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 3215 3220 3225 Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln 3230 3235 3240 Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn 3245 3250 3255 Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ser Gln Ser Leu 3260 3265 3270 Glu Thr Thr Ala Leu Phe Ser Val Pro Val Ile Leu Pro Phe Pro 3275 3280 3285 Glu Leu Asp Phe Lys Gly Leu 3290 3295 <210> 58 <211> 10795 <212> DNA <213> Homo sapiens <400> 58 actttccccc tacaggactc agatctggga ggcaattacc ttcggagaaa aacgaatagg 60 aaaaactgaa gtgttacttt ttttaaagct gctgaagttt gttggtttct cattgttttt 120 aagcctactg gagcaataaa gtttgaagaa cttttaccag gtttttttta tcgctgcctt 180 gatatacact tttcaaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag 240 atgttcaaaa gaaaacattc acaaaatggg taaatgcaca attttctaag tttgggaagc 300 agcatattga gaacctcttc agtgacctac aggatgggag gcgcctccta gacctcctcg 360 aaggcctgac agggcaaaaa ctgccaaaag aaaaaggatc cacaagagtt catgccctga 420 acaatgtcaa caaggcactg cgggttttgc agaacaataa tgttgattta gtgaatattg 480 gaagtactga catcgtagat ggaaatcata aactgactct tggtttgatt tggaatataa 540 tcctccactg gcaggtcaaa aatgtaatga aaaatatcat ggctggattg caacaaacca 600 acagtgaaaa gattctcctg agctgggtcc gacaatcaac tcgtaattat ccacaggtta 660 atgtaatcaa cttcaccacc agctggtctg atggcctggc tttgaatgct ctcatccata 720 gtcataggcc agacctattt gactggaata gtgtggtttg ccagcagtca gccacacaac 780 gactggaaca tgcattcaac atcgccagat atcaattagg catagagaaa ctactcgatc 840 ctgaagatgt tgataccacc tatccagata agaagtccat cttaatgtac atcacatcac 900 tcttccaagt tttgcctcaa caagtgagca ttgaagccat ccaggaagtg gaaatgttgc 960 caaggccacc taaagtgact aaagaagaac attttcagtt acatcatcaa atgcactatt 1020 ctcaacagat cacggtcagt ctagcacagg gatatgagag aacttcttcc cctaagcctc 1080 gattcaagag ctatgcctac acacaggctg cttatgtcac cacctctgac cctacacgga 1140 gcccatttcc ttcacagcat ttggaagctc ctgaagacaa gtcatttggc agttcattga 1200 tggagagtga agtaaacctg gaccgttatc aaacagcttt agaagaagta ttatcgtggc 1260 ttctttctgc tgaggacaca ttgcaagcac aaggagagat ttctaatgat gtggaagtgg 1320 tgaaagacca gtttcatact catgaggggt acatgatgga tttgacagcc catcagggcc 1380 gggttggtaa tattctacaa ttgggaagta agctgattgg aacaggaaaa ttatcagaag 1440 atgaagaaac tgaagtacaa gagcagatga atctcctaaa ttcaagatgg gaatgcctca 1500 gggtagctag catggaaaaa caaagcaatt tacatagagt tttaatggat ctccagaatc 1560 agaaactgaa agagttgaat gactggctaa caaaaacaga agaaagaaca aggaaaatgg 1620 aggaagagcc tcttggacct gatcttgaag acctaaaacg ccaagtacaa caacataagg 1680 tgcttcaaga agatctagaa caagaacaag tcagggtcaa ttctctcact cacatggtgg 1740 tggtagttga tgaatctagt ggagatcacg caactgctgc tttggaagaa caacttaagg 1800 tattgggaga tcgatgggca aacatctgta gatggacaga agaccgctgg gttcttttac 1860 aagacatcct tctcaaatgg caacgtctta ctgaagaaca gtgccttttt agtgcatggc 1920 tttcagaaaa agaagatgca gtgaacaaga ttcacacaac tggctttaaa gatcaaaatg 1980 aaatgttatc aagtcttcaa aaactggccg ttttaaaagc ggatctagaa aagaaaaagc 2040 aatccatggg caaactgtat tcactcaaac aagatcttct ttcaacactg aagaataagt 2100 cagtgaccca gaagacggaa gcatggctgg ataactttgc ccggtgttgg gataatttag 2160 tccaaaaact tgaaaagagt acagcacaga tttcacaggc tgtcaccacc actcagccat 2220 cactaacaca gacaactgta atggaaacag taactacggt gaccacaagg gaacagatcc 2280 tggtaaagca tgctcaagag gaacttccac caccacctcc ccaaaagaag aggcagatta 2340 ctgtggattc tgaaattagg aaaaggttgg atgttgatat aactgaactt cacagctgga 2400 ttactcgctc agaagctgtg ttgcagagtc ctgaatttgc aatctttcgg aaggaaggca 2460 acttctcaga cttaaaagaa aaagtcaatg ccatagagcg agaaaaagct gagaagttca 2520 gaaaactgca agatgccagc agatcagctc aggccctggt ggaacagatg gtgaatgagg 2580 gtgttaatgc agatagcatc aaacaagcct cagaacaact gaacagccgg tggatcgaat 2640 tctgccagtt gctaagtgag agacttaact ggctggagta tcagaacaac atcatcgctt 2700 tctataatca gctacaacaa ttggagcaga tgacaactac tgctgaaaac tggttgaaaa 2760 tccaacccac caccccatca gagccaacag caattaaaag tcagttaaaa atttgtaagg 2820 atgaagtcaa ccggctatca gatcttcaac ctcaaattga acgattaaaa attcaaagca 2880 tagccctgaa agagaaagga caaggaccca tgttcctgga tgcagacttt gtggccttta 2940 caaatcattt taagcaagtc ttttctgatg tgcaggccag agagaaagag ctacagacaa 3000 tttttgacac tttgccacca atgcgctatc aggagaccat gagtgccatc aggacatggg 3060 tccagcagtc agaaaccaaa ctctccatac ctcaacttag tgtcaccgac tatgaaatca 3120 tggagcagag actcggggaa ttgcaggctt tacaaagttc tctgcaagag caacaaagtg 3180 gcctatacta tctcagcacc actgtgaaag agatgtcgaa gaaagcgccc tctgaaatta 3240 gccggaaata tcaatcagaa tttgaagaaa ttgagggacg ctggaagaag ctctcctccc 3300 agctggttga gcattgtcaa aagctagagg agcaaatgaa taaactccga aaaattcaga 3360 atcacataca aaccctgaag aaatggatgg ctgaagttga tgtttttctg aaggaggaat 3420 ggcctgccct tggggattca gaaattctaa aaaagcagct gaaacagtgc agacttttag 3480 tcagtgatat tcagacaatt cagcccagtc taaacagtgt caatgaaggt gggcagaaga 3540 taaagaatga agcagagcca gagtttgctt cgagacttga gacagaactc aaagaactta 3600 acactcagtg ggatcacatg tgccaacagg tctatgccag aaaggaggcc ttgaagggag 3660 gtttggagaa aactgtaagc ctccagaaag atctatcaga gatgcacgaa tggatgacac 3720 aagctgaaga agagtatctt gagagagatt ttgaatataa aactccagat gaattacaga 3780 aagcagttga agagatgaag agagctaaag aagaggccca acaaaaagaa gcgaaagtga 3840 aactccttac tgagtctgta aatagtgtca tagctcaagc tccacctgta gcacaagagg 3900 ccttaaaaaa ggaacttgaa actctaacca ccaactacca gtggctctgc actaggctga 3960 atgggaaatg caagactttg gaagaagttt gggcatgttg gcatgagtta ttgtcatact 4020 tggagaaagc aaacaagtgg ctaaatgaag tagaatttaa acttaaaacc actgaaaaca 4080 ttcctggcgg agctgaggaa atctctgagg tgctagattc acttgaaaat ttgatgcgac 4140 attcagagga taacccaaat cagattcgca tattggcaca gaccctaaca gatggcggag 4200 tcatggatga gctaatcaat gaggaacttg agacatttaa ttctcgttgg agggaactac 4260 atgaagaggc tgtaaggagg caaaagttgc ttgaacagag catccagtct gcccaggaga 4320 ctgaaaaatc cttacactta atccaggagt ccctcacatt cattgacaag cagttggcag 4380 cttatattgc agacaaggtg gacgcagctc aaatgcctca ggaagcccag aaaatccaat 4440 ctgatttgac aagtcatgag atcagtttag aagaaatgaa gaaacataat caggggaagg 4500 aggctgccca aagagtcctg tctcagattg atgttgcaca gaaaaaatta caagatgtct 4560 ccatgaagtt tcgattattc cagaaaccag ccaattttga gcagcgtcta caagaaagta 4620 agatgatttt agatgaagtg aagatgcact tgcctgcatt ggaaacaaag agtgtggaac 4680 aggaagtagt acagtcacag ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag 4740 tgaagtctga agtggaaatg gtgataaaga ctggacgtca gattgtacag aaaaagcaga 4800 cggaaaatcc caaagaactt gatgaaagag taacagcttt gaaattgcat tataatgagc 4860 tgggagcaaa ggtaacagaa agaaagcaac agttggagaa atgcttgaaa ttgtcccgta 4920 agatgcgaaa ggaaatgaat gtcttgacag aatggctggc agctacagat atggaattga 4980 caaagagatc agcagttgaa ggaatgccta gtaatttgga ttctgaagtt gcctggggaa 5040 aggctactca aaaagagatt gagaaacaga aggtgcacct gaagagtatc acagaggtag 5100 gagaggcctt gaaaacagtt ttgggcaaga aggagacgtt ggtggaagat aaactcagtc 5160 ttctgaatag taactggata gctgtcacct cccgagcaga agagtggtta aatcttttgt 5220 tggaatacca gaaacacatg gaaacttttg accagaatgt ggaccacatc acaaagtgga 5280 tcattcaggc tgacacactt ttggatgaat cagagaaaaa gaaaccccag caaaaagaag 5340 acgtgcttaa gcgtttaaag gcagaactga atgacatacg cccaaaggtg gactctacac 5400 gtgaccaagc agcaaacttg atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc 5460 cccaaatctc agagctcaac catcgatttg cagccatttc acacagaatt aagactggaa 5520 aggcctccat tcctttgaag gaattggagc agtttaactc agatatacaa aaattgcttg 5580 aaccactgga ggctgaaatt cagcaggggg tgaatctgaa agaggaagac ttcaataaag 5640 atatgaatga agacaatgag ggtactgtaa aagaattgtt gcaaagagga gacaacttac 5700 aacaaagaat cacagatgag agaaagcgag aggaaataaa gataaaacag cagctgttac 5760 agacaaaaca taatgctctc aaggatttga ggtctcaaag aagaaaaaag gctctagaaa 5820 tttctcatca gtggtatcag tacaagaggc aggctgatga tctcctgaaa tgcttggatg 5880 acattgaaaa aaaattagcc agcctacctg agcccagaga tgaaaggaaa ataaaggaaa 5940 ttgatcggga attgcagaag aagaaagagg agctgaatgc agtgcgtagg caagctgagg 6000 gcttgtctga ggatggggcc gcaatggcag tggagccaac tcagatccag ctcagcaagc 6060 gctggcggga aattgagagc aaatttgctc agtttcgaag actcaacttt gcacaaattc 6120 acactgtccg tgaagaaacg atgatggtga tgactgaaga catgcctttg gaaatttctt 6180 atgtgccttc tacttatttg actgaaatca ctcatgtctc acaagcccta ttagaagtgg 6240 aacaacttct caatgctcct gacctctgtg ctaaggactt tgaagatctc tttaagcaag 6300 aggagtctct gaagaatata aaagatagtc tacaacaaag ctcaggtcgg attgacatta 6360 ttcatagcaa gaagacagca gcattgcaaa gtgcaacgcc tgtggaaagg gtgaagctac 6420 aggaagctct ctcccagctt gatttccaat gggaaaaagt taacaaaatg tacaaggacc 6480 gacaagggcg atttgacaga tctgttgaga aatggcggcg ttttcattat gatataaaga 6540 tatttaatca gtggctaaca gaagctgaac agtttctcag aaagacacaa attcctgaga 6600 attgggaaca tgctaaatac aaatggtatc ttaagagaac aggagacaga ggacttatcc 6660 ttcttgatga tgtcatttga aaagaatggc tttcaggtcc ttgagtgaga gacacttctg 6720 atttccaaga gctacatgtt cacaattgta agcccttttg agtaaatgtt ctaagaaacg 6780 gaggtaagag tcctatcaac agatgtgtgt tggctagaac aaacattaaa ttttcctggc 6840 agcactgagc tttctcaagc aggcacttaa gggaaggcta gggtcatcct agggacatgg 6900 ccttctgggg ctagaaacca tactagagtt tagtcaagtc ttagtgcaag ggtttggaca 6960 gagttgttaa gtgctgagag ttctgtattt ctcactgtca caaaggaaga tcagaagctc 7020 ctgatacttt tttcatcagt acaattgaat atataaatcc tatacacaaa aataaactaa 7080 gcttatacaa gcatattggt caaggaatgt tgctggcctt attaattaga tagcccagtt 7140 aaaagaagaa ttttttaata taattaatgt taaagtagga tgatagtata taaaacgtgt 7200 ctactgtcct gaatacaaac taaactgttt ggtttagcat ttacctcaag atctcttaat 7260 atcccccaaa gggtccctaa aaccacaact tatctttgtg ctcatgaagt agagaagaga 7320 cagttaatag acatttctag ctgatagact gttgtagagc agagaacgct ctgtgttttt 7380 gaaaattaaa catatgaatt tgcccctctt cccctattaa ggaagaagag tttcttaatt 7440 gtgcgaacac atcaagtgaa ctattcaatt agatttttgt gacccagggt ataaacatct 7500 ggttaaggtt acatatttca aaggaacaaa acactagaaa ctcttggttt taaatctcat 7560 ggctggagga taatttgcag cagagattta tctggcaagc atacagaatt gctgagactg 7620 ttctaaagat gtaagtgtgg gtgtttgtgt cgtgaaaata gctgtttaca tctattaagt 7680 ggataccgat ggttgaaagt gccgtctatg tcaagttttt accaaatcaa cttttgcctc 7740 actgtgtcag accattttac ctaatcaact tggactgcta atgtcctttc ccctggcacc 7800 actatctgtc tcttttgcaa agcacagaaa cggcatgcat gattgtagtt tataaaacac 7860 atgtaccaat gtggtctaca gcttctgttg agttcgagag ggtcagtttc tgtaatctct 7920 tctggcacag agtcaagaac agcttcactt tcctcctgct acctctctac ccgtaagtgt 7980 gaacccatca ctttgctaac actcaggaag gggattacac aaaatagagc aggagccctc 8040 tgacctgaat atgcatctga gccctagcca tagagcttct gattcagtag atctgggatg 8100 gggcctaaat atttgcattt ttaagtgtat aagtgatgct gatgctgctg gttccaggac 8160 cacattttaa gaaatatcga taaaggtgga gaattaaact gcagctcaga agacctgagt 8220 tcttgcccca gcttgacttt tacaatctag caaatggata aaactcgcag gacttcagtt 8280 ctcttcatct acacagtgag tggttagatt ggctttgtaa tttaaaatta aacagggttt 8340 gattctgatt cactacacaa ggttccaaag aaggaatgat atctcctttc atttcttcac 8400 tttgtcttct gtccctaggt aatcttatct atgttcctga tttaacctaa ctaatgtttc 8460 tgcaaagctt ctaatattta catctccagc cctgaaactc tcatttgaat gctagtctta 8520 tatacatacc cccctgccta attgacatct ccacttaaat gtatcagagg caactcagac 8580 tcaacaagga ccaaactgaa tgttcgacct tgtccttcaa acccgataca catccaggtt 8640 cctccatccc agtgaatgac actatccagt taagcaagcc aaaagtctgg attttttttc 8700 ctcactcttc ctcactgtcc gtcaactacc attattaaat ctgtcacctg gtcctactga 8760 tttaaccttc tcaatatctc tacagttttt ctttatgccc attagtatcc tagtgcaagc 8820 taccatcgtc tctcattgga attaacacag taacccccct acccaccaga ctgttctgcc 8880 tacagatagt gtgatattta ataaatataa atctagcctt ggctagattt ctccttcaaa 8940 aggttcacat taattttagc cttaaaatgg tgtgcaaagc tttgcatagt ctgtcctttg 9000 ctatgttggc agtatttttt actatccctc tcatctgctc attctctgta ctccaactac 9060 actaactttg tttttttttt tttttagatt tctctaacta cagtgctgta atctcttttt 9120 cctttgcacg tactattccg tttgtcaggg aatctgctca ctgtctccac ccactccaca 9180 cactcacgtt ttcctgcccg tcttaccggt cttgatcggt tgtcacttgc tcaggaaggt 9240 ttccctggtc accccctcca caaattgaat taagtcctct tgctgcatgc tgtcctagtg 9300 ctctttattt tcctctcctc atccttaatt cagtttgtaa ttacatgtta tttgtgtgag 9360 gatttgatta ttatctgtgt cacccactag atattgggca ttctttactt actcaccact 9420 gaattcatag aaccacagta attgtacaca acaaatattc aagagaaatt tattgaattg 9480 atgaatgaaa agttgtacct taacatgttc ctgacatgta tccaaaaaag agctcccctt 9540 tggggtctat taggactttg gacctaggta aacgtaaccc tagtttcgct caggtttaaa 9600 cagtagaaag taattgggtc tcttttgcat gtggctttcc taagggctaa ccctgtcttc 9660 ggaatgagtc aatacagcag agctgttgaa agcagactct agcttcggac aacgttggtc 9720 cgaatcatgg ttccgtcatt tcttagctgt gtgatttaga ataaattaat gttttaaagc 9780 tttgatttcc tcttccttaa tctggagatg ctaataaagc caacttcgta gaggtattgc 9840 gatgagtaaa taagcataat ttgctgtaaa caccttgcag attgcctgtt gtatgctaac 9900 taatcaataa attgaagctc ttaacatcat tatattagat atttccagca ttgagtatac 9960 tatcaggcat gtggtagaag ctcaatataa agttttgtta aattgaatag attccatata 10020 tggtatttct acagcattat gctccttatt taagtgtctc taagtatttt ttaagtatca 10080 cctcacaaaa gacagatgtt taattcatta cacatgtgaa ttgttttaga tagaaaataa 10140 aataaaaaat tcaaacattg aaatcaatag tgtaccttac cttaggatta caccataaaa 10200 tttctaccaa tcgagaataa agtgtacagt ctatttcctt tctaatactt ttaacgcaac 10260 aaatgtttat tgaacactta ctacttctaa tctatgacag acataaagat gaataaagca 10320 tgccacaatg tttaaaggag ctcactatat cataagaaag cggattcaca cagacaactc 10380 tataagataa agtggtaaat ttaggctggc ctgtgaaaca aaggattata ggtatagtta 10440 agaggtggaa tttattttac ttcgaggatt tcagttacct ttatattctt tgtctaacct 10500 ttcatgtttc tctttcttca gaaacagagc acctttttcc tgacacattc atttccccct 10560 atggagtaga gcagttgttt tcaaagtgtg ggtcccagat cagcatcacg gggatggtta 10620 gaaatgccca ttcttgagcc tcacaacaga cctactgaaa cagaaattct tggagagtgg 10680 agcccgcaga tctgtgatca agccctgtag gcaattctaa cgcacactca agttaaagaa 10740 ccacgggaag aaaggtccat cctgtaacaa gacagatttt tttcattagc atcaa 10795 <210> 59 <211> 2160 <212> PRT <213> Homo sapiens <400> 59 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser 1775 1780 1785 Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln 1790 1795 1800 Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu 1805 1810 1815 Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn 1820 1825 1830 Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys 1835 1840 1845 Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp 1850 1855 1860 Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln 1865 1870 1875 Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu 1880 1885 1890 Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp 1895 1900 1905 Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys 1910 1915 1920 Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu 1925 1930 1935 Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser 1940 1945 1950 Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg 1955 1960 1965 Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met 1970 1975 1980 Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser 1985 1990 1995 Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu 2000 2005 2010 Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe 2015 2020 2025 Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp 2030 2035 2040 Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys 2045 2050 2055 Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 2060 2065 2070 Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 2075 2080 2085 Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 2090 2095 2100 Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 2105 2110 2115 Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro 2120 2125 2130 Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Arg Thr 2135 2140 2145 Gly Asp Arg Gly Leu Ile Leu Leu Asp Asp Val Ile 2150 2155 2160 <210> 60 <211> 24 <212> DNA <213> Homo sapiens <400> 60 tctttttctt cttttttcct tttt 24 <210> 61 <211> 24 <212> DNA <213> Homo sapiens <400> 61 ctttttcttc ttttttcctt tttg 24 <210> 62 <211> 24 <212> DNA <213> Homo sapiens <400> 62 tttttcttct tttttccttt ttgc 24 <210> 63 <211> 24 <212> DNA <213> Homo sapiens <400> 63 tcttcttttt tcctttttgc aaaa 24 <210> 64 <211> 24 <212> DNA <213> Homo sapiens <400> 64 cttctttttt cctttttgca aaaa 24 <210> 65 <211> 24 <212> DNA <213> Homo sapiens <400> 65 ttcttttttc ctttttgcaa aaac 24 <210> 66 <211> 24 <212> DNA <213> Homo sapiens <400> 66 ttcctttttg caaaaaccca aaat 24 <210> 67 <211> 24 <212> DNA <213> Homo sapiens <400> 67 tcctttttgc aaaaacccaa aata 24 <210> 68 <211> 24 <212> DNA <213> Homo sapiens <400> 68 cctttttgca aaaacccaaa atat 24 <210> 69 <211> 24 <212> DNA <213> Homo sapiens <400> 69 ctttttgcaa aaacccaaaa tatt 24 <210> 70 <211> 24 <212> DNA <213> Homo sapiens <400> 70 tgcaaaaacc caaaatattt tagc 24 <210> 71 <211> 24 <212> DNA <213> Homo sapiens <400> 71 gcaaaaaccc aaaatatttt agct 24 <210> 72 <211> 24 <212> DNA <213> Homo sapiens <400> 72 caaaaaccca aaatatttta gctc 24 <210> 73 <211> 24 <212> DNA <213> Homo sapiens <400> 73 agctcctact cagactgtta ctct 24 <210> 74 <211> 24 <212> DNA <213> Homo sapiens <400> 74 gctcctactc agactgttac tctg 24 <210> 75 <211> 24 <212> DNA <213> Homo sapiens <400> 75 cttagtaacc acaggttgtg tcac 24 <210> 76 <211> 24 <212> DNA <213> Homo sapiens <400> 76 gagatggcag tttccttagt aacc 24 <210> 77 <211> 24 <212> DNA <213> Homo sapiens <400> 77 tagtttggag atggcagttt cctt 24 <210> 78 <211> 24 <212> DNA <213> Homo sapiens <400> 78 ttctcatacc ttctgcttga tgat 24 <210> 79 <211> 24 <212> DNA <213> Homo sapiens <400> 79 tcattttttc tcataccttc tgct 24 <210> 80 <211> 24 <212> DNA <213> Homo sapiens <400> 80 atcatttttt ctcatacctt ctgc 24 <210> 81 <211> 24 <212> DNA <213> Homo sapiens <400> 81 aagaaaaact tctgccaact ttta 24 <210> 82 <211> 24 <212> DNA <213> Homo sapiens <400> 82 aaagaaaaac ttctgccaac tttt 24 <210> 83 <211> 24 <212> DNA <213> Homo sapiens <400> 83 tctttaaaat gaagattttc cacc 24 <210> 84 <211> 24 <212> DNA <213> Homo sapiens <400> 84 ctttaaaatg aagattttcc acca 24 <210> 85 <211> 24 <212> DNA <213> Homo sapiens <400> 85 tttaaaatga agattttcca ccaa 24 <210> 86 <211> 24 <212> DNA <213> Homo sapiens <400> 86 aaatgaagat tttccaccaa tcac 24 <210> 87 <211> 24 <212> DNA <213> Homo sapiens <400> 87 ccaccaatca ctttactctc ctag 24 <210> 88 <211> 24 <212> DNA <213> Homo sapiens <400> 88 caccaatcac tttactctcc taga 24 <210> 89 <211> 24 <212> DNA <213> Homo sapiens <400> 89 ctctcctaga ccatttccca ccag 24 <210> 90 <211> 24 <212> DNA <213> Homo sapiens <400> 90 agaaaagatt aaacagtgtg ctac 24 <210> 91 <211> 24 <212> DNA <213> Homo sapiens <400> 91 tttgagaaaa gattaaacag tgtg 24 <210> 92 <211> 24 <212> DNA <213> Homo sapiens <400> 92 atttgagaaa agattaaaca gtgt 24 <210> 93 <211> 24 <212> DNA <213> Homo sapiens <400> 93 tatttgagaa aagattaaac agtg 24 <210> 94 <211> 24 <212> DNA <213> Homo sapiens <400> 94 atcttttctc aaataaaaag acat 24 <210> 95 <211> 24 <212> DNA <213> Homo sapiens <400> 95 ctcaaataaa aagacatggg gctt 24 <210> 96 <211> 24 <212> DNA <213> Homo sapiens <400> 96 tcaaataaaa agacatgggg cttc 24 <210> 97 <211> 24 <212> DNA <213> Homo sapiens <400> 97 tgttttgcct ttttggtatc ttac 24 <210> 98 <211> 24 <212> DNA <213> Homo sapiens <400> 98 gttttgcctt tttggtatct taca 24 <210> 99 <211> 24 <212> DNA <213> Homo sapiens <400> 99 ttttgccttt ttggtatctt acag 24 <210> 100 <211> 24 <212> DNA <213> Homo sapiens <400> 100 gcctttttgg tatcttacag gaac 24 <210> 101 <211> 24 <212> DNA <213> Homo sapiens <400> 101 cctttttggt atcttacagg aact 24 <210> 102 <211> 24 <212> DNA <213> Homo sapiens <400> 102 tggtatctta caggaactcc agga 24 <210> 103 <211> 24 <212> DNA <213> Homo sapiens <400> 103 ggtatcttac aggaactcca ggat 24 <210> 104 <211> 24 <212> DNA <213> Homo sapiens <400> 104 aggattgctg aattatttct tccc 24 <210> 105 <211> 24 <212> DNA <213> Homo sapiens <400> 105 gaggattgct gaattatttc ttcc 24 <210> 106 <211> 24 <212> DNA <213> Homo sapiens <400> 106 tgaggattgc tgaattattt cttc 24 <210> 107 <211> 24 <212> DNA <213> Homo sapiens <400> 107 ctgtagaata ctggcatctg tttt 24 <210> 108 <211> 24 <212> DNA <213> Homo sapiens <400> 108 cctgtagaat actggcatct gttt 24 <210> 109 <211> 24 <212> DNA <213> Homo sapiens <400> 109 tcctgtagaa tactggcatc tgtt 24 <210> 110 <211> 24 <212> DNA <213> Homo sapiens <400> 110 cagacctcct gccaccgcag attc 24 <210> 111 <211> 24 <212> DNA <213> Homo sapiens <400> 111 tgtctgacag ctgtttgcag acct 24 <210> 112 <211> 24 <212> DNA <213> Homo sapiens <400> 112 ctgtctgaca gctgtttgca gacc 24 <210> 113 <211> 24 <212> DNA <213> Homo sapiens <400> 113 tctgtctgac agctgtttgc agac 24 <210> 114 <211> 24 <212> DNA <213> Homo sapiens <400> 114 ttctgtctga cagctgtttg caga 24 <210> 115 <211> 24 <212> DNA <213> Homo sapiens <400> 115 attcctatta gatctgtcgc ccta 24 <210> 116 <211> 24 <212> DNA <213> Homo sapiens <400> 116 cattcctatt agatctgtcg ccct 24 <210> 117 <211> 24 <212> DNA <213> Homo sapiens <400> 117 agcagacttt ttaagctttc ttta 24 <210> 118 <211> 24 <212> DNA <213> Homo sapiens <400> 118 gcagactttt taagctttct ttag 24 <210> 119 <211> 24 <212> DNA <213> Homo sapiens <400> 119 taagctttct ttagaagaat attt 24 <210> 120 <211> 24 <212> DNA <213> Homo sapiens <400> 120 aagctttctt tagaagaata tttc 24 <210> 121 <211> 24 <212> DNA <213> Homo sapiens <400> 121 agctttcttt agaagaatat ttca 24 <210> 122 <211> 24 <212> DNA <213> Homo sapiens <400> 122 tttagaagaa tatttcatga gaga 24 <210> 123 <211> 24 <212> DNA <213> Homo sapiens <400> 123 gaagaatatt tcatgagaga ttat 24 <210> 124 <211> 24 <212> DNA <213> Homo sapiens <400> 124 tcagtataac caaaaaatat acgc 24 <210> 125 <211> 24 <212> DNA <213> Homo sapiens <400> 125 acataatcca tctatttttc ttga 24 <210> 126 <211> 24 <212> DNA <213> Homo sapiens <400> 126 cataatccat ctatttttct tgat 24 <210> 127 <211> 24 <212> DNA <213> Homo sapiens <400> 127 tcttgatcca tatgctttta cctg 24 <210> 128 <211> 24 <212> DNA <213> Homo sapiens <400> 128 cttgatccat atgcttttac ctgc 24 <210> 129 <211> 24 <212> DNA <213> Homo sapiens <400> 129 ttgatccata tgcttttacc tgca 24 <210> 130 <211> 24 <212> DNA <213> Homo sapiens <400> 130 tcaacagatc tgtcaaatcg cctg 24 <210> 131 <211> 24 <212> DNA <213> Homo sapiens <400> 131 acctgcaggc gatttgacag atct 24 <210> 132 <211> 24 <212> DNA <213> Homo sapiens <400> 132 cctgcaggcg atttgacaga tctg 24 <210> 133 <211> 24 <212> DNA <213> Homo sapiens <400> 133 acagatctgt tgagaaatgg cggc 24 <210> 134 <211> 24 <212> DNA <213> Homo sapiens <400> 134 tatcataatg aaaacgccgc catt 24 <210> 135 <211> 24 <212> DNA <213> Homo sapiens <400> 135 cattatgata taaagatatt taat 24 <210> 136 <211> 24 <212> DNA <213> Homo sapiens <400> 136 tatttagcat gttcccaatt ctca 24 <210> 137 <211> 24 <212> DNA <213> Homo sapiens <400> 137 gaaaaaacaa atcaaagact tacc 24 <210> 138 <211> 24 <212> DNA <213> Homo sapiens <400> 138 atttgttttt tcgaaattgt attt 24 <210> 139 <211> 24 <212> DNA <213> Homo sapiens <400> 139 ttttttcgaa attgtattta tctt 24 <210> 140 <211> 24 <212> DNA <213> Homo sapiens <400> 140 ttcgaaattg tatttatctt cagc 24 <210> 141 <211> 24 <212> DNA <213> Homo sapiens <400> 141 tcgaaattgt atttatcttc agca 24 <210> 142 <211> 24 <212> DNA <213> Homo sapiens <400> 142 cgaaattgta tttatcttca gcac 24 <210> 143 <211> 24 <212> DNA <213> Homo sapiens <400> 143 gaaattgtat ttatcttcag caca 24 <210> 144 <211> 24 <212> DNA <213> Homo sapiens <400> 144 agaagttaaa gagtccagat gtgc 24 <210> 145 <211> 24 <212> DNA <213> Homo sapiens <400> 145 tcttcagcac atctggactc ttta 24 <210> 146 <211> 24 <212> DNA <213> Homo sapiens <400> 146 catcaccctt cagaacctga tctt 24 <210> 147 <211> 24 <212> DNA <213> Homo sapiens <400> 147 acttcttaaa gatcaggttc tgaa 24 <210> 148 <211> 24 <212> DNA <213> Homo sapiens <400> 148 gactgttgtt gtcatcatta tatt 24 <210> 149 <211> 24 <212> DNA <213> Homo sapiens <400> 149 actgttgttg tcatcattat atta 24 <210> 150 <211> 24 <212> DNA <213> Homo sapiens <400> 150 aactagaata aaaggaaaaa taaa 24 <210> 151 <211> 24 <212> DNA <213> Homo sapiens <400> 151 ctactatata tttatttttc cttt 24 <210> 152 <211> 24 <212> DNA <213> Homo sapiens <400> 152 tttttccttt tattctagtt gaaa 24 <210> 153 <211> 24 <212> DNA <213> Homo sapiens <400> 153 tccttttatt ctagttgaaa gaat 24 <210> 154 <211> 24 <212> DNA <213> Homo sapiens <400> 154 ccttttattc tagttgaaag aatt 24 <210> 155 <211> 24 <212> DNA <213> Homo sapiens <400> 155 cttttattct agttgaaaga attc 24 <210> 156 <211> 24 <212> DNA <213> Homo sapiens <400> 156 attctagttg aaagaattca gaat 24 <210> 157 <211> 24 <212> DNA <213> Homo sapiens <400> 157 ttctagttga aagaattcag aatc 24 <210> 158 <211> 24 <212> DNA <213> Homo sapiens <400> 158 attcaactgt tgcctccggt tctg 24 <210> 159 <211> 24 <212> DNA <213> Homo sapiens <400> 159 acatttcatt caactgttgc ctcc 24 <210> 160 <211> 24 <212> DNA <213> Homo sapiens <400> 160 cttttggatt gcatctactg tata 24 <210> 161 <211> 24 <212> DNA <213> Homo sapiens <400> 161 tgtgattttc ttttggattg catc 24 <210> 162 <211> 24 <212> DNA <213> Homo sapiens <400> 162 atactaacct tggtttctgt gatt 24 <210> 163 <211> 24 <212> DNA <213> Homo sapiens <400> 163 aaaaggtatc tttgatacta acct 24 <210> 164 <211> 24 <212> DNA <213> Homo sapiens <400> 164 aaaaaggtat ctttgatact aacc 24 <210> 165 <211> 24 <212> DNA <213> Homo sapiens <400> 165 ttttaaaaag gtatctttga tact 24 <210> 166 <211> 24 <212> DNA <213> Homo sapiens <400> 166 attttaaaaa ggtatctttg atac 24 <210> 167 <211> 24 <212> DNA <213> Homo sapiens <400> 167 ttaatgcaaa ctgggacaca aaca 24 <210> 168 <211> 24 <212> DNA <213> Homo sapiens <400> 168 taaattgcca tgtttgtgtc ccag 24 <210> 169 <211> 24 <212> DNA <213> Homo sapiens <400> 169 aaattgccat gtttgtgtcc cagt 24 <210> 170 <211> 24 <212> DNA <213> Homo sapiens <400> 170 aattgccatg tttgtgtccc agtt 24 <210> 171 <211> 24 <212> DNA <213> Homo sapiens <400> 171 tgtcccagtt tgcattaaca aata 24 <210> 172 <211> 24 <212> DNA <213> Homo sapiens <400> 172 caacatagtt ctcaaactat ttgt 24 <210> 173 <211> 24 <212> DNA <213> Homo sapiens <400> 173 ccaacatagt tctcaaacta tttg 24 <210> 174 <211> 24 <212> DNA <213> Homo sapiens <400> 174 tccaacatag ttctcaaact attt 24 <210> 175 <211> 24 <212> DNA <213> Homo sapiens <400> 175 tttccaacat agttctcaaa ctat 24 <210> 176 <211> 24 <212> DNA <213> Homo sapiens <400> 176 ttttccaaca tagttctcaa acta 24 <210> 177 <211> 24 <212> DNA <213> Homo sapiens <400> 177 tttttccaac atagttctca aact 24 <210> 178 <211> 24 <212> DNA <213> Homo sapiens <400> 178 cattaacaaa tagtttgaga acta 24 <210> 179 <211> 24 <212> DNA <213> Homo sapiens <400> 179 agaactatgt tggaaaaaaa aata 24 <210> 180 <211> 24 <212> DNA <213> Homo sapiens <400> 180 gttcttctag cctggagaaa gaag 24 <210> 181 <211> 24 <212> DNA <213> Homo sapiens <400> 181 attcttcttt ctccaggcta gaag 24 <210> 182 <211> 24 <212> DNA <213> Homo sapiens <400> 182 ttcttctttc tccaggctag aaga 24 <210> 183 <211> 24 <212> DNA <213> Homo sapiens <400> 183 tccaggctag aagaacaaaa gaat 24 <210> 184 <211> 24 <212> DNA <213> Homo sapiens <400> 184 aaattctgac aagatattct tttg 24 <210> 185 <211> 24 <212> DNA <213> Homo sapiens <400> 185 cttttagttg ctgctctttt ccag 24 <210> 186 <211> 24 <212> DNA <213> Homo sapiens <400> 186 agaaaataaa attaccttga cttg 24 <210> 187 <211> 24 <212> DNA <213> Homo sapiens <400> 187 tgcaagcagg ccctggggga tttg 24 <210> 188 <211> 24 <212> DNA <213> Homo sapiens <400> 188 attttctcaa atcccccagg gcct 24 <210> 189 <211> 24 <212> DNA <213> Homo sapiens <400> 189 ttttctcaaa tcccccaggg cctg 24 <210> 190 <211> 24 <212> DNA <213> Homo sapiens <400> 190 ctcaaatccc ccagggcctg cttg 24 <210> 191 <211> 24 <212> DNA <213> Homo sapiens <400> 191 tcaaatcccc cagggcctgc ttgc 24 <210> 192 <211> 24 <212> DNA <213> Homo sapiens <400> 192 ttaattcaat cattggtttt ctgc 24 <210> 193 <211> 24 <212> DNA <213> Homo sapiens <400> 193 taattcaatc attggttttc tgcc 24 <210> 194 <211> 24 <212> DNA <213> Homo sapiens <400> 194 aattcaatca ttggttttct gccc 24 <210> 195 <211> 24 <212> DNA <213> Homo sapiens <400> 195 attcaatcat tggttttctg ccca 24 <210> 196 <211> 24 <212> DNA <213> Homo sapiens <400> 196 gcaaggaact atgaataacc taat 24 <210> 197 <211> 24 <212> DNA <213> Homo sapiens <400> 197 ctgcccatta ggttattcat agtt 24 <210> 198 <211> 24 <212> DNA <213> Homo sapiens <400> 198 tgcccattag gttattcata gttc 24 <210> 199 <211> 24 <212> DNA <213> Homo sapiens <400> 199 tagaaaacaa tttaacagga aata 24 <210> 200 <211> 24 <212> DNA <213> Homo sapiens <400> 200 ctgttaaatt gttttctata aacc 24 <210> 201 <211> 24 <212> DNA <213> Homo sapiens <400> 201 gaaataaaaa agatgttact gtat 24 <210> 202 <211> 24 <212> DNA <213> Homo sapiens <400> 202 agaaataaaa aagatgttac tgta 24 <210> 203 <211> 24 <212> DNA <213> Homo sapiens <400> 203 ctataaaccc ttatacagta acat 24 <210> 204 <211> 24 <212> DNA <213> Homo sapiens <400> 204 tataaaccct tatacagtaa catc 24 <210> 205 <211> 24 <212> DNA <213> Homo sapiens <400> 205 ttatttctaa aagtgttttg gctg 24 <210> 206 <211> 24 <212> DNA <213> Homo sapiens <400> 206 tatttctaaa agtgttttgg ctgg 24 <210> 207 <211> 24 <212> DNA <213> Homo sapiens <400> 207 atttctaaaa gtgttttggc tggt 24 <210> 208 <211> 24 <212> DNA <213> Homo sapiens <400> 208 tttctaaaag tgttttggct ggtc 24 <210> 209 <211> 24 <212> DNA <213> Homo sapiens <400> 209 taaaagtgtt ttggctggtc tcac 24 <210> 210 <211> 24 <212> DNA <213> Homo sapiens <400> 210 cataatacaa agtaaagtac aatt 24 <210> 211 <211> 24 <212> DNA <213> Homo sapiens <400> 211 acataataca aagtaaagta caat 24 <210> 212 <211> 24 <212> DNA <213> Homo sapiens <400> 212 ggctggtctc acaattgtac ttta 24 <210> 213 <211> 24 <212> DNA <213> Homo sapiens <400> 213 gctggtctca caattgtact ttac 24 <210> 214 <211> 24 <212> DNA <213> Homo sapiens <400> 214 ctttgtatta tgtaaaagga atac 24 <210> 215 <211> 24 <212> DNA <213> Homo sapiens <400> 215 tattatgtaa aaggaataca caac 24 <210> 216 <211> 24 <212> DNA <213> Homo sapiens <400> 216 ttcttacagg caacaatgca ggat 24 <210> 217 <211> 24 <212> DNA <213> Homo sapiens <400> 217 gaacagaggc gtccccagtt ggaa 24 <210> 218 <211> 24 <212> DNA <213> Homo sapiens <400> 218 ggcagcggta atgagttctt ccaa 24 <210> 219 <211> 24 <212> DNA <213> Homo sapiens <400> 219 tcaaattttg ggcagcggta atga 24 <210> 220 <211> 24 <212> DNA <213> Homo sapiens <400> 220 aaaaacaaga ccagcaatca agag 24 <210> 221 <211> 24 <212> DNA <213> Homo sapiens <400> 221 tgtgtcccat gcttgttaaa aaac 24 <210> 222 <211> 24 <212> DNA <213> Homo sapiens <400> 222 ttaacaagca tgggacacac aaag 24 <210> 223 <211> 24 <212> DNA <213> Homo sapiens <400> 223 taacaagcat gggacacaca aagc 24 <210> 224 <211> 24 <212> DNA <213> Homo sapiens <400> 224 aacaagcatg ggacacacaa agca 24 <210> 225 <211> 24 <212> DNA <213> Homo sapiens <400> 225 acaagcatgg gacacacaaa gcaa 24 <210> 226 <211> 24 <212> DNA <213> Homo sapiens <400> 226 ttgaaacttg tcatgcatct tgct 24 <210> 227 <211> 24 <212> DNA <213> Homo sapiens <400> 227 attgaaactt gtcatgcatc ttgc 24 <210> 228 <211> 24 <212> DNA <213> Homo sapiens <400> 228 tattgaaact tgtcatgcat cttg 24 <210> 229 <211> 24 <212> DNA <213> Homo sapiens <400> 229 aataaaaact taagttcata tatc 24 <210> 230 <211> 24 <212> DNA <213> Homo sapiens <400> 230 gtgaatatat tattggattt ctat 24 <210> 231 <211> 24 <212> DNA <213> Homo sapiens <400> 231 aagataattc atgaacatct taat 24 <210> 232 <211> 24 <212> DNA <213> Homo sapiens <400> 232 acagaaaagc atacacatta ctta 24 <210> 233 <211> 24 <212> DNA <213> Homo sapiens <400> 233 ctgttaaaga ggaagttaga agat 24 <210> 234 <211> 24 <212> DNA <213> Homo sapiens <400> 234 tgttaaagag gaagttagaa gatc 24 <210> 235 <211> 24 <212> DNA <213> Homo sapiens <400> 235 ccgccttcca ctcagagctc agat 24 <210> 236 <211> 24 <212> DNA <213> Homo sapiens <400> 236 ccctcagctc ttgaagtaaa cggt 24 <210> 237 <211> 24 <212> DNA <213> Homo sapiens <400> 237 cttcaagagc tgagggcaaa gcag 24 <210> 238 <211> 24 <212> DNA <213> Homo sapiens <400> 238 aacaaatagc tagagccaaa gaga 24 <210> 239 <211> 24 <212> DNA <213> Homo sapiens <400> 239 gaacaaatag ctagagccaa agag 24 <210> 240 <211> 24 <212> DNA <213> Homo sapiens <400> 240 gctctagcta tttgttcaaa agtg 24 <210> 241 <211> 24 <212> DNA <213> Homo sapiens <400> 241 ttcaaaagtg caactatgaa gtga 24 <210> 242 <211> 24 <212> DNA <213> Homo sapiens <400> 242 tctctcaccc agtcatcact tcat 24 <210> 243 <211> 24 <212> DNA <213> Homo sapiens <400> 243 ctctctcacc cagtcatcac ttca 24 <210> 244 <211> 24 <212> DNA <213> Homo sapiens <400> 244 tatatatata tatatttttc tctt 24 <210> 245 <211> 24 <212> DNA <213> Homo sapiens <400> 245 tctctttcta tagacagcta attc 24 <210> 246 <211> 24 <212> DNA <213> Homo sapiens <400> 246 ctctttctat agacagctaa ttca 24 <210> 247 <211> 24 <212> DNA <213> Homo sapiens <400> 247 aaacagtaaa aaaatgaatt agct 24 <210> 248 <211> 24 <212> DNA <213> Homo sapiens <400> 248 tctttctata gacagctaat tcat 24 <210> 249 <211> 24 <212> DNA <213> Homo sapiens <400> 249 aaaacagtaa aaaaatgaat tagc 24 <210> 250 <211> 24 <212> DNA <213> Homo sapiens <400> 250 tatagacagc taattcattt tttt 24 <210> 251 <211> 24 <212> DNA <213> Homo sapiens <400> 251 tattctgtaa tataaaaatt ttaa 24 <210> 252 <211> 24 <212> DNA <213> Homo sapiens <400> 252 atattctgta atataaaaat ttta 24 <210> 253 <211> 24 <212> DNA <213> Homo sapiens <400> 253 tttactgttt taaaattttt atat 24 <210> 254 <211> 24 <212> DNA <213> Homo sapiens <400> 254 ttactgtttt aaaattttta tatt 24 <210> 255 <211> 24 <212> DNA <213> Homo sapiens <400> 255 tactgtttta aaatttttat atta 24 <210> 256 <211> 24 <212> DNA <213> Homo sapiens <400> 256 actgttttaa aatttttata ttac 24 <210> 257 <211> 24 <212> DNA <213> Homo sapiens <400> 257 ctgttttaaa atttttatat taca 24 <210> 258 <211> 24 <212> DNA <213> Homo sapiens <400> 258 aaaattttta tattacagaa tata 24 <210> 259 <211> 24 <212> DNA <213> Homo sapiens <400> 259 aaatttttat attacagaat ataa 24 <210> 260 <211> 24 <212> DNA <213> Homo sapiens <400> 260 ttgtagacta tcttttatat tctg 24 <210> 261 <211> 24 <212> DNA <213> Homo sapiens <400> 261 tatattacag aatataaaag atag 24 <210> 262 <211> 24 <212> DNA <213> Homo sapiens <400> 262 atattacaga atataaaaga tagt 24 <210> 263 <211> 24 <212> DNA <213> Homo sapiens <400> 263 tattacagaa tataaaagat agtc 24 <210> 264 <211> 24 <212> DNA <213> Homo sapiens <400> 264 caatgctgct gtcttcttgc tatg 24 <210> 265 <211> 24 <212> DNA <213> Homo sapiens <400> 265 caatgggaaa aagttaacaa aatg 24 <210> 266 <211> 24 <212> DNA <213> Homo sapiens <400> 266 tgcaagtatc aagaaaaata tatg 24 <210> 267 <211> 24 <212> DNA <213> Homo sapiens <400> 267 tcttgatact tgcagaaatg attt 24 <210> 268 <211> 24 <212> DNA <213> Homo sapiens <400> 268 cttgatactt gcagaaatga tttg 24 <210> 269 <211> 24 <212> DNA <213> Homo sapiens <400> 269 ttgatacttg cagaaatgat ttgt 24 <210> 270 <211> 24 <212> DNA <213> Homo sapiens <400> 270 ttttcaggga actgtagaat ttat 24 <210> 271 <211> 24 <212> DNA <213> Homo sapiens <400> 271 catggagggt actgaaataa attc 24 <210> 272 <211> 24 <212> DNA <213> Homo sapiens <400> 272 ccatggaggg tactgaaata aatt 24 <210> 273 <211> 24 <212> DNA <213> Homo sapiens <400> 273 cagggaactg tagaatttat ttca 24 <210> 274 <211> 24 <212> DNA <213> Homo sapiens <400> 274 tccatggagg gtactgaaat aaat 24 <210> 275 <211> 24 <212> DNA <213> Homo sapiens <400> 275 agggaactgt agaatttatt tcag 24 <210> 276 <211> 24 <212> DNA <213> Homo sapiens <400> 276 ttccatggag ggtactgaaa taaa 24 <210> 277 <211> 24 <212> DNA <213> Homo sapiens <400> 277 cctgtctttt ttccatggag ggta 24 <210> 278 <211> 24 <212> DNA <213> Homo sapiens <400> 278 ccctgtcttt tttccatgga gggt 24 <210> 279 <211> 24 <212> DNA <213> Homo sapiens <400> 279 tccctgtctt ttttccatgg aggg 24 <210> 280 <211> 24 <212> DNA <213> Homo sapiens <400> 280 tttcagtacc ctccatggaa aaaa 24 <210> 281 <211> 24 <212> DNA <213> Homo sapiens <400> 281 agtaccctcc atggaaaaaa gaca 24 <210> 282 <211> 24 <212> DNA <213> Homo sapiens <400> 282 agtttgcatg gttcttgctc aagg 24 <210> 283 <211> 24 <212> DNA <213> Homo sapiens <400> 283 ataagaaaat gcattccttg agca 24 <210> 284 <211> 24 <212> DNA <213> Homo sapiens <400> 284 cataagaaaa tgcattcctt gagc 24 <210> 285 <211> 24 <212> DNA <213> Homo sapiens <400> 285 catggttctt gctcaaggaa tgca 24 <210> 286 <211> 24 <212> DNA <213> Homo sapiens <400> 286 acctacatgt ggaaataaat tttc 24 <210> 287 <211> 24 <212> DNA <213> Homo sapiens <400> 287 gacctacatg tggaaataaa tttt 24 <210> 288 <211> 24 <212> DNA <213> Homo sapiens <400> 288 tgacctacat gtggaaataa attt 24 <210> 289 <211> 24 <212> DNA <213> Homo sapiens <400> 289 cttatgaaaa tttatttcca catg 24 <210> 290 <211> 24 <212> DNA <213> Homo sapiens <400> 290 ttatgaaaat ttatttccac atgt 24 <210> 291 <211> 24 <212> DNA <213> Homo sapiens <400> 291 attacatttt tgacctacat gtgg 24 <210> 292 <211> 24 <212> DNA <213> Homo sapiens <400> 292 cattacattt ttgacctaca tgtg 24 <210> 293 <211> 24 <212> DNA <213> Homo sapiens <400> 293 tcattacatt tttgacctac atgt 24 <210> 294 <211> 24 <212> DNA <213> Homo sapiens <400> 294 tttccacatg taggtcaaaa atgt 24 <210> 295 <211> 24 <212> DNA <213> Homo sapiens <400> 295 cacatgtagg tcaaaaatgt aatg 24 <210> 296 <211> 24 <212> DNA <213> Homo sapiens <400> 296 ttgcaatcca gccatgatat tttt 24 <210> 297 <211> 24 <212> DNA <213> Homo sapiens <400> 297 actgttggtt tgttgcaatc cagc 24 <210> 298 <211> 24 <212> DNA <213> Homo sapiens <400> 298 cactgttggt ttgttgcaat ccag 24 <210> 299 <211> 24 <212> DNA <213> Homo sapiens <400> 299 aatgctctca tccatagtca tagg 24 <210> 300 <211> 24 <212> DNA <213> Homo sapiens <400> 300 atgtctcagt aatcttctta ccta 24 <210> 301 <211> 24 <212> DNA <213> Homo sapiens <400> 301 caagttattt aatgtctcag taat 24 <210> 302 <211> 24 <212> DNA <213> Homo sapiens <400> 302 acaagttatt taatgtctca gtaa 24 <210> 303 <211> 24 <212> DNA <213> Homo sapiens <400> 303 gactctgatg acatattttt cccc 24 <210> 304 <211> 24 <212> DNA <213> Homo sapiens <400> 304 tccccagtat ggttccagat catg 24 <210> 305 <211> 24 <212> DNA <213> Homo sapiens <400> 305 ccccagtatg gttccagatc atgt 24 <210> 306 <211> 24 <212> DNA <213> Homo sapiens <400> 306 cccagtatgg ttccagatca tgtc 24 <210> 307 <211> 24 <212> DNA <213> Homo sapiens <400> 307 tatttgtctt tgtgtatgtg tgta 24 <210> 308 <211> 24 <212> DNA <213> Homo sapiens <400> 308 tctttgtgta tgtgtgtatg tgta 24 <210> 309 <211> 24 <212> DNA <213> Homo sapiens <400> 309 tgtatgtgtg tatgtgtatg tgtt 24 <210> 310 <211> 24 <212> DNA <213> Homo sapiens <400> 310 aggccagacc tatttgactg gaat 24 <210> 311 <211> 24 <212> DNA <213> Homo sapiens <400> 311 ggccagacct atttgactgg aata 24 <210> 312 <211> 24 <212> DNA <213> Homo sapiens <400> 312 actggaatag tgtggtttgc cagc 24 <210> 313 <211> 24 <212> DNA <213> Homo sapiens <400> 313 ccagcagtca gccacacaac gact 24 <210> 314 <211> 24 <212> DNA <213> Homo sapiens <400> 314 tctatgccta attgatatct ggcg 24 <210> 315 <211> 24 <212> DNA <213> Homo sapiens <400> 315 ccaaccttca ggatcgagta gttt 24 <210> 316 <211> 24 <212> DNA <213> Homo sapiens <400> 316 tggactacca ctgcttttag tatg 24 <210> 317 <211> 24 <212> DNA <213> Homo sapiens <400> 317 agtatggtag agtttaatgt tttc 24 <210> 318 <211> 24 <212> DNA <213> Homo sapiens <400> 318 gtatggtaga gtttaatgtt ttca 24 <210> 319 <211> 24 <212> DNA <213> Homo sapiens <400> 319 agactctaaa aggataatga acaa 24 <210> 320 <211> 24 <212> DNA <213> Homo sapiens <400> 320 actttgattt gttcattatc cttt 24 <210> 321 <211> 24 <212> DNA <213> Homo sapiens <400> 321 tatatttgag actctaaaag gata 24 <210> 322 <211> 24 <212> DNA <213> Homo sapiens <400> 322 atttgttcat tatcctttta gagt 24 <210> 323 <211> 24 <212> DNA <213> Homo sapiens <400> 323 gtttctatat ttgagactct aaaa 24 <210> 324 <211> 24 <212> DNA <213> Homo sapiens <400> 324 ggtttctata tttgagactc taaa 24 <210> 325 <211> 24 <212> DNA <213> Homo sapiens <400> 325 tggtttctat atttgagact ctaa 24 <210> 326 <211> 24 <212> DNA <213> Homo sapiens <400> 326 ttcattatcc ttttagagtc tcaa 24 <210> 327 <211> 24 <212> DNA <213> Homo sapiens <400> 327 agagtctcaa atatagaaac caaa 24 <210> 328 <211> 24 <212> DNA <213> Homo sapiens <400> 328 gagtctcaaa tatagaaacc aaaa 24 <210> 329 <211> 24 <212> DNA <213> Homo sapiens <400> 329 cacttcctgg atggcttcaa tgct 24 <210> 330 <211> 24 <212> DNA <213> Homo sapiens <400> 330 gcctcaacaa gtgagcattg aagc 24 <210> 331 <211> 24 <212> DNA <213> Homo sapiens <400> 331 cctcaacaag tgagcattga agcc 24 <210> 332 <211> 24 <212> DNA <213> Homo sapiens <400> 332 ggtggccttg gcaacatttc cact 24 <210> 333 <211> 24 <212> DNA <213> Homo sapiens <400> 333 gtcactttag gtggccttgg caac 24 <210> 334 <211> 24 <212> DNA <213> Homo sapiens <400> 334 atgatgtaac tgaaaatgtt cttc 24 <210> 335 <211> 24 <212> DNA <213> Homo sapiens <400> 335 cctgttgaga atagtgcatt tgat 24 <210> 336 <211> 24 <212> DNA <213> Homo sapiens <400> 336 cagttacatc atcaaatgca ctat 24 <210> 337 <211> 24 <212> DNA <213> Homo sapiens <400> 337 agttacatca tcaaatgcac tatt 24 <210> 338 <211> 24 <212> DNA <213> Homo sapiens <400> 338 cacactttac ctgttgagaa tagt 24 <210> 339 <211> 24 <212> DNA <213> Homo sapiens <400> 339 ctgttttata tgcattttta ggta 24 <210> 340 <211> 24 <212> DNA <213> Homo sapiens <400> 340 tgttttatat gcatttttag gtat 24 <210> 341 <211> 24 <212> DNA <213> Homo sapiens <400> 341 atatgcattt ttaggtatta cgtg 24 <210> 342 <211> 24 <212> DNA <213> Homo sapiens <400> 342 tatgcatttt taggtattac gtgc 24 <210> 343 <211> 24 <212> DNA <213> Homo sapiens <400> 343 taggtattac gtgcacatat atat 24 <210> 344 <211> 24 <212> DNA <213> Homo sapiens <400> 344 aggtattacg tgcacatata tata 24 <210> 345 <211> 24 <212> DNA <213> Homo sapiens <400> 345 ggtattacgt gcacatatat atat 24 <210> 346 <211> 24 <212> DNA <213> Homo sapiens <400> 346 agcaacaact ataatattgt gcag 24 <210> 347 <211> 24 <212> DNA <213> Homo sapiens <400> 347 gttcctccat ctttctcttt ttat 24 <210> 348 <211> 24 <212> DNA <213> Homo sapiens <400> 348 tctttttatg gagttcacta ggtg 24 <210> 349 <211> 24 <212> DNA <213> Homo sapiens <400> 349 tatggagttc actaggtgca ccat 24 <210> 350 <211> 24 <212> DNA <213> Homo sapiens <400> 350 atggagttca ctaggtgcac catt 24 <210> 351 <211> 24 <212> DNA <213> Homo sapiens <400> 351 tggagttcac taggtgcacc attc 24 <210> 352 <211> 24 <212> DNA <213> Homo sapiens <400> 352 ataattgcat ctgaacattt ggtc 24 <210> 353 <211> 24 <212> DNA <213> Homo sapiens <400> 353 gtcctttgca gggtgagtga gcga 24 <210> 354 <211> 24 <212> DNA <213> Homo sapiens <400> 354 ttccaaagca gcctctcgct cact 24 <210> 355 <211> 24 <212> DNA <213> Homo sapiens <400> 355 cagggtgagt gagcgagagg ctgc 24 <210> 356 <211> 24 <212> DNA <213> Homo sapiens <400> 356 gaagaaactc atagattact gcaa 24 <210> 357 <211> 24 <212> DNA <213> Homo sapiens <400> 357 caggtccagg gggaactgtt gcag 24 <210> 358 <211> 24 <212> DNA <213> Homo sapiens <400> 358 ccaggtccag ggggaactgt tgca 24 <210> 359 <211> 24 <212> DNA <213> Homo sapiens <400> 359 agcttctgta agccaggcaa gaaa 24 <210> 360 <211> 24 <212> DNA <213> Homo sapiens <400> 360 ttgcctggct tacagaagct gaaa 24 <210> 361 <211> 24 <212> DNA <213> Homo sapiens <400> 361 cttacgggta gcatcctgta ggac 24 <210> 362 <211> 24 <212> DNA <213> Homo sapiens <400> 362 ctcccttgga gtcttctagg agcc 24 <210> 363 <211> 24 <212> DNA <213> Homo sapiens <400> 363 actcccttgg agtcttctag gagc 24 <210> 364 <211> 24 <212> DNA <213> Homo sapiens <400> 364 atcagctctt ttactccctt ggag 24 <210> 365 <211> 24 <212> DNA <213> Homo sapiens <400> 365 cgctttagca ctcttgtgga tcca 24 <210> 366 <211> 24 <212> DNA <213> Homo sapiens <400> 366 gcactcttgt ggatccaatt gaac 24 <210> 367 <211> 24 <212> DNA <213> Homo sapiens <400> 367 tccctggctt gtcagttaca agta 24 <210> 368 <211> 24 <212> DNA <213> Homo sapiens <400> 368 gtccctggct tgtcagttac aagt 24 <210> 369 <211> 24 <212> DNA <213> Homo sapiens <400> 369 ttttgtccct ggcttgtcag ttac 24 <210> 370 <211> 24 <212> DNA <213> Homo sapiens <400> 370 gttttgtccc tggcttgtca gtta 24 <210> 371 <211> 24 <212> DNA <213> Homo sapiens <400> 371 tacttgtaac tgacaagcca ggga 24 <210> 372 <211> 24 <212> DNA <213> Homo sapiens <400> 372 gctcctactc agactgttac tctg 24 <210> 373 <211> 24 <212> DNA <213> Homo sapiens <400> 373 taccatgtat tgctaaacaa agta 24 <210> 374 <211> 24 <212> DNA <213> Homo sapiens <400> 374 attgaagagt aacaatttga gcca 24 <210> 375 <211> 24 <212> DNA <213> Mus musculus <400> 375 aggctctgca aagttctttg aaag 24 <210> 376 <211> 24 <212> DNA <213> Mus musculus <400> 376 aaagagcaac aaaatggctt caac 24 <210> 377 <211> 24 <212> DNA <213> Mus musculus <400> 377 aaagagcaat aaaatggctt caac 24 <210> 378 <211> 24 <212> DNA <213> Mus musculus <400> 378 aaagaacttt gcagagcctc aaaa 24 <210> 379 <211> 24 <212> DNA <213> Mus musculus <400> 379 ctgaatatct atgcattaat aact 24 <210> 380 <211> 24 <212> DNA <213> Mus musculus <400> 380 tattatatta cagggcatat tata 24 <210> 381 <211> 24 <212> DNA <213> Mus musculus <400> 381 aggtaagccg aggtttggcc ttta 24 <210> 382 <211> 24 <212> DNA <213> Mus musculus <400> 382 cccagagtcc ttcaaagata ttga 24 <210> 383 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 383 aaaaaggaaa aaagaagaaa aaga 24 <210> 384 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 384 caaaaaggaa aaaagaagaa aaag 24 <210> 385 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 385 gcaaaaagga aaaaagaaga aaaa 24 <210> 386 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 386 uuuugcaaaa aggaaaaaag aaga 24 <210> 387 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 387 uuuuugcaaa aaggaaaaaa gaag 24 <210> 388 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 388 guuuuugcaa aaaggaaaaa agaa 24 <210> 389 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 389 auuuuggguu uuugcaaaaa ggaa 24 <210> 390 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 390 uauuuugggu uuuugcaaaa agga 24 <210> 391 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 391 auauuuuggg uuuuugcaaa aagg 24 <210> 392 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 392 aauauuuugg guuuuugcaa aaag 24 <210> 393 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 393 gcuaaaauau uuuggguuuu ugca 24 <210> 394 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 394 agcuaaaaua uuuuggguuu uugc 24 <210> 395 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 395 gagcuaaaau auuuuggguu uuug 24 <210> 396 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 396 agaguaacag ucugaguagg agcu 24 <210> 397 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 397 cagaguaaca gucugaguag gagc 24 <210> 398 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 398 gugacacaac cugugguuac uaag 24 <210> 399 <211> 23 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 399 gguuacuaag gaaacugcca ucu 23 <210> 400 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 400 aaggaaacug ccaucuccaa acua 24 <210> 401 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 401 aucaucaagc agaagguaug agaa 24 <210> 402 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 402 agcagaaggu augagaaaaa auga 24 <210> 403 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 403 gcagaaggua ugagaaaaaa ugau 24 <210> 404 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 404 uaaaaguugg cagaaguuuu ucuu 24 <210> 405 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 405 aaaaguuggc agaaguuuuu cuuu 24 <210> 406 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 406 gguggaaaau cuucauuuua aaga 24 <210> 407 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 407 ugguggaaaa ucuucauuuu aaag 24 <210> 408 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 408 uugguggaaa aucuucauuu uaaa 24 <210> 409 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 409 gugauuggug gaaaaucuuc auuu 24 <210> 410 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 410 cuaggagagu aaagugauug gugg 24 <210> 411 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 411 ucuaggagag uaaagugauu ggug 24 <210> 412 <211> 23 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 412 cuggugggaa auggucuagg aga 23 <210> 413 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 413 guagcacacu guuuaaucuu uucu 24 <210> 414 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 414 cacacuguuu aaucuuuucu caaa 24 <210> 415 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 415 acacuguuua aucuuuucuc aaau 24 <210> 416 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 416 cacuguuuaa ucuuuucuca aaua 24 <210> 417 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 417 augucuuuuu auuugagaaa agau 24 <210> 418 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 418 aagccccaug ucuuuuuauu ugag 24 <210> 419 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 419 gaagccccau gucuuuuuau uuga 24 <210> 420 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 420 guaagauacc aaaaaggcaa aaca 24 <210> 421 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 421 uguaagauac caaaaaggca aaac 24 <210> 422 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 422 cuguaagaua ccaaaaaggc aaaa 24 <210> 423 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 423 guuccuguaa gauaccaaaa aggc 24 <210> 424 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 424 aguuccugua agauaccaaa aagg 24 <210> 425 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 425 uccuggaguu ccuguaagau acca 24 <210> 426 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 426 auccuggagu uccuguaaga uacc 24 <210> 427 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 427 gggaagaaau aauucagcaa uccu 24 <210> 428 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 428 ggaagaaaua auucagcaau ccuc 24 <210> 429 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 429 gaagaaauaa uucagcaauc cuca 24 <210> 430 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 430 aaaacagaug ccaguauucu acag 24 <210> 431 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 431 aaacagaugc caguauucua cagg 24 <210> 432 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 432 aacagaugcc aguauucuac agga 24 <210> 433 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 433 gaaucugcgg uggcaggagg ucug 24 <210> 434 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 434 aggucugcaa acagcuguca gaca 24 <210> 435 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 435 ggucugcaaa cagcugucag acag 24 <210> 436 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 436 gucugcaaac agcugucaga caga 24 <210> 437 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 437 ucugcaaaca gcugucagac agaa 24 <210> 438 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 438 uagggcgaca gaucuaauag gaau 24 <210> 439 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 439 agggcgacag aucuaauagg aaug 24 <210> 440 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 440 uaaagaaagc uuaaaaaguc ugcu 24 <210> 441 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 441 cuaaagaaag cuuaaaaagu cugc 24 <210> 442 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 442 aaauauucuu cuaaagaaag cuua 24 <210> 443 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 443 gaaauauucu ucuaaagaaa gcuu 24 <210> 444 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 444 ugaaauauuc uucuaaagaa agcu 24 <210> 445 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 445 ucucucauga aauauucuuc uaaa 24 <210> 446 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 446 auaaucucuc augaaauauu cuuc 24 <210> 447 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 447 gcguauauuu uuugguuaua cuga 24 <210> 448 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 448 ucaagaaaaa uagauggauu augu 24 <210> 449 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 449 aucaagaaaa auagauggau uaug 24 <210> 450 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 450 cagguaaaag cauauggauc aaga 24 <210> 451 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 451 gcagguaaaa gcauauggau caag 24 <210> 452 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 452 ugcagguaaa agcauaugga ucaa 24 <210> 453 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 453 caggcgauuu gacagaucug uuga 24 <210> 454 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 454 agaucuguca aaucgccugc aggu 24 <210> 455 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 455 cagaucuguc aaaucgccug cagg 24 <210> 456 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 456 gccgccauuu cucaacagau cugu 24 <210> 457 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 457 aauggcggcg uuuucauuau gaua 24 <210> 458 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 458 auuaaauauc uuuauaucau aaug 24 <210> 459 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 459 ugagaauugg gaacaugcua aaua 24 <210> 460 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 460 gguaagucuu ugauuuguuu uuuc 24 <210> 461 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 461 aaauacaauu ucgaaaaaac aaau 24 <210> 462 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 462 aagauaaaua caauuucgaa aaaa 24 <210> 463 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 463 gcugaagaua aauacaauuu cgaa 24 <210> 464 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 464 ugcugaagau aaauacaauu ucga 24 <210> 465 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 465 gugcugaaga uaaauacaau uucg 24 <210> 466 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 466 ugugcugaag auaaauacaa uuuc 24 <210> 467 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 467 gcacaucugg acucuuuaac uucu 24 <210> 468 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 468 uaaagagucc agaugugcug aaga 24 <210> 469 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 469 aagaucaggu ucugaagggu gaug 24 <210> 470 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 470 uucagaaccu gaucuuuaag aagu 24 <210> 471 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 471 aauauaauga ugacaacaac aguc 24 <210> 472 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 472 uaauauaaug augacaacaa cagu 24 <210> 473 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 473 uuuauuuuuc cuuuuauucu aguu 24 <210> 474 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 474 aaaggaaaaa uaaauauaua guag 24 <210> 475 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 475 uuucaacuag aauaaaagga aaaa 24 <210> 476 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 476 auucuuucaa cuagaauaaa agga 24 <210> 477 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 477 aauucuuuca acuagaauaa aagg 24 <210> 478 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 478 gaauucuuuc aacuagaaua aaag 24 <210> 479 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 479 auucugaauu cuuucaacua gaau 24 <210> 480 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 480 gauucugaau ucuuucaacu agaa 24 <210> 481 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 481 cagaaccgga ggcaacaguu gaau 24 <210> 482 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 482 ggaggcaaca guugaaugaa augu 24 <210> 483 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 483 uauacaguag augcaaucca aaag 24 <210> 484 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 484 gaugcaaucc aaaagaaaau caca 24 <210> 485 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 485 aaucacagaa accaagguua guau 24 <210> 486 <211> 23 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 486 agguuaguau caaagauacc uuu 23 <210> 487 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 487 gguuaguauc aaagauaccu uuuu 24 <210> 488 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 488 aguaucaaag auaccuuuuu aaaa 24 <210> 489 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 489 guaucaaaga uaccuuuuua aaau 24 <210> 490 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 490 uguuuguguc ccaguuugca uuaa 24 <210> 491 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 491 cugggacaca aacauggcaa uuua 24 <210> 492 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 492 acugggacac aaacauggca auuu 24 <210> 493 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 493 aacugggaca caaacauggc aauu 24 <210> 494 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 494 uauuuguuaa ugcaaacugg gaca 24 <210> 495 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 495 acaaauaguu ugagaacuau guug 24 <210> 496 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 496 caaauaguuu gagaacuaug uugg 24 <210> 497 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 497 aaauaguuug agaacuaugu ugga 24 <210> 498 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 498 auaguuugag aacuauguug gaaa 24 <210> 499 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 499 uaguuugaga acuauguugg aaaa 24 <210> 500 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 500 aguuugagaa cuauguugga aaaa 24 <210> 501 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 501 uaguucucaa acuauuuguu aaug 24 <210> 502 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 502 uauuuuuuuu uccaacauag uucu 24 <210> 503 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 503 cuucuuucuc caggcuagaa gaac 24 <210> 504 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 504 cuucuagccu ggagaaagaa gaau 24 <210> 505 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 505 ucuucuagcc uggagaaaga agaa 24 <210> 506 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 506 auucuuuugu ucuucuagcc ugga 24 <210> 507 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 507 caaaagaaua ucuugucaga auuu 24 <210> 508 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 508 cuggaaaaga gcagcaacua aaag 24 <210> 509 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 509 caagucaagg uaauuuuauu uucu 24 <210> 510 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 510 caaauccccc agggccugcu ugca 24 <210> 511 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 511 aggcccuggg ggauuugaga aaau 24 <210> 512 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 512 caggcccugg gggauuugag aaaa 24 <210> 513 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 513 caagcaggcc cugggggauu ugag 24 <210> 514 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 514 gcaagcaggc ccugggggau uuga 24 <210> 515 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 515 gcagaaaacc aaugauugaa uuaa 24 <210> 516 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 516 ggcagaaaac caaugauuga auua 24 <210> 517 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 517 gggcagaaaa ccaaugauug aauu 24 <210> 518 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 518 ugggcagaaa accaaugauu gaau 24 <210> 519 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 519 auuagguuau ucauaguucc uugc 24 <210> 520 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 520 aacuaugaau aaccuaaugg gcag 24 <210> 521 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 521 gaacuaugaa uaaccuaaug ggca 24 <210> 522 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 522 uauuuccugu uaaauuguuu ucua 24 <210> 523 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 523 gguuuauaga aaacaauuua acag 24 <210> 524 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 524 auacaguaac aucuuuuuua uuuc 24 <210> 525 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 525 uacaguaaca ucuuuuuuau uucu 24 <210> 526 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 526 auguuacugu auaaggguuu auag 24 <210> 527 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 527 gauguuacug uauaaggguu uaua 24 <210> 528 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 528 cagccaaaac acuuuuagaa auaa 24 <210> 529 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 529 ccagccaaaa cacuuuuaga aaua 24 <210> 530 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 530 accagccaaa acacuuuuag aaau 24 <210> 531 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 531 gaccagccaa aacacuuuua gaaa 24 <210> 532 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 532 gugagaccag ccaaaacacu uuua 24 <210> 533 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 533 aauuguacuu uacuuuguau uaug 24 <210> 534 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 534 auuguacuuu acuuuguauu augu 24 <210> 535 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 535 uaaaguacaa uugugagacc agcc 24 <210> 536 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 536 guaaaguaca auugugagac cagc 24 <210> 537 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 537 guauuccuuu uacauaauac aaag 24 <210> 538 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 538 guuguguauu ccuuuuacau aaua 24 <210> 539 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 539 auccugcauu guugccugua agaa 24 <210> 540 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 540 uuccaacugg ggacgccucu guuc 24 <210> 541 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 541 uuggaagaac ucauuaccgc ugcc 24 <210> 542 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 542 ucauuaccgc ugcccaaaau uuga 24 <210> 543 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 543 cucuugauug cuggucuugu uuuu 24 <210> 544 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 544 guuuuuuaac aagcauggga caca 24 <210> 545 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 545 cuuugugugu cccaugcuug uuaa 24 <210> 546 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 546 gcuuugugug ucccaugcuu guua 24 <210> 547 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 547 ugcuuugugu gucccaugcu uguu 24 <210> 548 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 548 uugcuuugug ugucccaugc uugu 24 <210> 549 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 549 agcaagaugc augacaaguu ucaa 24 <210> 550 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 550 gcaagaugca ugacaaguuu caau 24 <210> 551 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 551 caagaugcau gacaaguuuc aaua 24 <210> 552 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 552 gauauaugaa cuuaaguuuu uauu 24 <210> 553 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 553 auagaaaucc aauaauauau ucac 24 <210> 554 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 554 auuaagaugu ucaugaauua ucuu 24 <210> 555 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 555 uaaguaaugu guaugcuuuu cugu 24 <210> 556 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 556 aucuucuaac uuccucuuua acag 24 <210> 557 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 557 gaucuucuaa cuuccucuuu aaca 24 <210> 558 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 558 aucugagcuc ugaguggaag gcgg 24 <210> 559 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 559 accguuuacu ucaagagcug aggg 24 <210> 560 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 560 cugcuuugcc cucagcucuu gaag 24 <210> 561 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 561 ucucuuuggc ucuagcuauu uguu 24 <210> 562 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 562 cucuuuggcu cuagcuauuu guuc 24 <210> 563 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 563 cacuuuugaa caaauagcua gagc 24 <210> 564 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 564 ucacuucaua guugcacuuu ugaa 24 <210> 565 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 565 augaagugau gacuggguga gaga 24 <210> 566 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 566 ugaagugaug acugggugag agag 24 <210> 567 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 567 aagagaaaaa uauauauaua uaua 24 <210> 568 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 568 gaauuagcug ucuauagaaa gaga 24 <210> 569 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 569 ugaauuagcu gucuauagaa agag 24 <210> 570 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 570 agcuaauuca uuuuuuuacu guuu 24 <210> 571 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 571 augaauuagc ugucuauaga aaga 24 <210> 572 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 572 gcuaauucau uuuuuuacug uuuu 24 <210> 573 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 573 aaaaaaauga auuagcuguc uaua 24 <210> 574 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 574 uuaaaauuuu uauauuacag aaua 24 <210> 575 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 575 uaaaauuuuu auauuacaga auau 24 <210> 576 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 576 auauaaaaau uuuaaaacag uaaa 24 <210> 577 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 577 aauauaaaaa uuuuaaaaca guaa 24 <210> 578 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 578 uaauauaaaa auuuuaaaac agua 24 <210> 579 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 579 guaauauaaa aauuuuaaaa cagu 24 <210> 580 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 580 uguaauauaa aaauuuuaaa acag 24 <210> 581 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 581 uauauucugu aauauaaaaa uuuu 24 <210> 582 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 582 uuauauucug uaauauaaaa auuu 24 <210> 583 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 583 cagaauauaa aagauagucu acaa 24 <210> 584 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 584 cuaucuuuua uauucuguaa uaua 24 <210> 585 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 585 acuaucuuuu auauucugua auau 24 <210> 586 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 586 gacuaucuuu uauauucugu aaua 24 <210> 587 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 587 cauagcaaga agacagcagc auug 24 <210> 588 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 588 cauuuuguua acuuuuuccc auug 24 <210> 589 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 589 cauauauuuu ucuugauacu ugca 24 <210> 590 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 590 aaaucauuuc ugcaaguauc aaga 24 <210> 591 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 591 caaaucauuu cugcaaguau caag 24 <210> 592 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 592 acaaaucauu ucugcaagua ucaa 24 <210> 593 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 593 auaaauucua caguucccug aaaa 24 <210> 594 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 594 gaauuuauuu caguacccuc caug 24 <210> 595 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 595 aauuuauuuc aguacccucc augg 24 <210> 596 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 596 ugaaauaaau ucuacaguuc ccug 24 <210> 597 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 597 auuuauuuca guacccucca ugga 24 <210> 598 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 598 cugaaauaaa uucuacaguu cccu 24 <210> 599 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 599 uuuauuucag uacccuccau ggaa 24 <210> 600 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 600 uacccuccau ggaaaaaaga cagg 24 <210> 601 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 601 acccuccaug gaaaaaagac aggg 24 <210> 602 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 602 cccuccaugg aaaaaagaca ggga 24 <210> 603 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 603 uuuuuuccau ggaggguacu gaaa 24 <210> 604 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 604 ugucuuuuuu ccauggaggg uacu 24 <210> 605 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 605 ccuugagcaa gaaccaugca aacu 24 <210> 606 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 606 ugcucaagga augcauuuuc uuau 24 <210> 607 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 607 gcucaaggaa ugcauuuucu uaug 24 <210> 608 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 608 ugcauuccuu gagcaagaac caug 24 <210> 609 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 609 gaaaauuuau uuccacaugu aggu 24 <210> 610 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 610 aaaauuuauu uccacaugua gguc 24 <210> 611 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 611 aaauuuauuu ccacauguag guca 24 <210> 612 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 612 cauguggaaa uaaauuuuca uaag 24 <210> 613 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 613 acauguggaa auaaauuuuc auaa 24 <210> 614 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 614 ccacauguag gucaaaaaug uaau 24 <210> 615 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 615 cacauguagg ucaaaaaugu aaug 24 <210> 616 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 616 acauguaggu caaaaaugua auga 24 <210> 617 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 617 acauuuuuga ccuacaugug gaaa 24 <210> 618 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 618 cauuacauuu uugaccuaca ugug 24 <210> 619 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 619 aaaaauauca uggcuggauu gcaa 24 <210> 620 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 620 gcuggauugc aacaaaccaa cagu 24 <210> 621 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 621 cuggauugca acaaaccaac agug 24 <210> 622 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 622 ccuaugacua uggaugagag cauu 24 <210> 623 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 623 uagguaagaa gauuacugag acau 24 <210> 624 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 624 auuacugaga cauuaaauaa cuug 24 <210> 625 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 625 uuacugagac auuaaauaac uugu 24 <210> 626 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 626 ggggaaaaau augucaucag aguc 24 <210> 627 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 627 caugaucugg aaccauacug ggga 24 <210> 628 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 628 acaugaucug gaaccauacu gggg 24 <210> 629 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 629 gacaugaucu ggaaccauac uggg 24 <210> 630 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 630 uacacacaua cacaaagaca aaua 24 <210> 631 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 631 uacacauaca cacauacaca aaga 24 <210> 632 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 632 aacacauaca cauacacaca uaca 24 <210> 633 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 633 auuccaguca aauaggucug gccu 24 <210> 634 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 634 uauuccaguc aaauaggucu ggcc 24 <210> 635 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 635 gcuggcaaac cacacuauuc cagu 24 <210> 636 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 636 agucguugug uggcugacug cugg 24 <210> 637 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 637 cgccagauau caauuaggca uaga 24 <210> 638 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 638 aaacuacucg auccugaagg uugg 24 <210> 639 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 639 cauacuaaaa gcagugguag ucca 24 <210> 640 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 640 gaaaacauua aacucuacca uacu 24 <210> 641 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 641 ugaaaacauu aaacucuacc auac 24 <210> 642 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 642 uuguucauua uccuuuuaga gucu 24 <210> 643 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 643 aaaggauaau gaacaaauca aagu 24 <210> 644 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 644 uauccuuuua gagucucaaa uaua 24 <210> 645 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 645 acucuaaaag gauaaugaac aaau 24 <210> 646 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 646 uuuuagaguc ucaaauauag aaac 24 <210> 647 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 647 uuuagagucu caaauauaga aacc 24 <210> 648 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 648 uuagagucuc aaauauagaa acca 24 <210> 649 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 649 uugagacucu aaaaggauaa ugaa 24 <210> 650 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 650 uuugguuucu auauuugaga cucu 24 <210> 651 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 651 uuuugguuuc uauauuugag acuc 24 <210> 652 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 652 agcauugaag ccauccagga agug 24 <210> 653 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 653 gcuucaaugc ucacuuguug aggc 24 <210> 654 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 654 ggcuucaaug cucacuuguu gagg 24 <210> 655 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 655 aguggaaaug uugccaaggc cacc 24 <210> 656 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 656 guugccaagg ccaccuaaag ugac 24 <210> 657 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 657 gaagaacauu uucaguuaca ucau 24 <210> 658 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 658 aucaaaugca cuauucucaa cagg 24 <210> 659 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 659 auagugcauu ugaugaugua acug 24 <210> 660 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 660 aauagugcau uugaugaugu aacu 24 <210> 661 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 661 acuauucuca acagguaaag ugug 24 <210> 662 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 662 uaccuaaaaa ugcauauaaa acag 24 <210> 663 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 663 auaccuaaaa augcauauaa aaca 24 <210> 664 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 664 cacguaauac cuaaaaaugc auau 24 <210> 665 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 665 gcacguaaua ccuaaaaaug caua 24 <210> 666 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 666 auauauaugu gcacguaaua ccua 24 <210> 667 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 667 uauauauaug ugcacguaau accu 24 <210> 668 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 668 auauauauau gugcacguaa uacc 24 <210> 669 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 669 cugcacaaua uuauaguugu ugcu 24 <210> 670 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 670 auaaaaagag aaagauggag gaac 24 <210> 671 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 671 caccuaguga acuccauaaa aaga 24 <210> 672 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 672 auggugcacc uagugaacuc caua 24 <210> 673 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 673 aauggugcac cuagugaacu ccau 24 <210> 674 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 674 gaauggugca ccuagugaac ucca 24 <210> 675 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 675 gaccaaaugu ucagaugcaa uuau 24 <210> 676 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 676 ucgcucacuc acccugcaaa ggac 24 <210> 677 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 677 agugagcgag aggcugcuuu ggaa 24 <210> 678 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 678 gcagccucuc gcucacucac ccug 24 <210> 679 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 679 uugcaguaau cuaugaguuu cuuc 24 <210> 680 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 680 cugcaacagu ucccccugga ccug 24 <210> 681 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 681 ugcaacaguu cccccuggac cugg 24 <210> 682 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 682 uuucuugccu ggcuuacaga agcu 24 <210> 683 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 683 uuucagcuuc uguaagccag gcaa 24 <210> 684 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 684 guccuacagg augcuacccg uaag 24 <210> 685 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 685 ggcuccuaga agacuccaag ggag 24 <210> 686 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 686 gcuccuagaa gacuccaagg gagu 24 <210> 687 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 687 cuccaaggga guaaaagagc ugau 24 <210> 688 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 688 uggauccaca agagugcuaa agcg 24 <210> 689 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 689 guucaauugg auccacaaga gugc 24 <210> 690 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 690 uacuuguaac ugacaagcca ggga 24 <210> 691 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 691 acuuguaacu gacaagccag ggac 24 <210> 692 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 692 guaacugaca agccagggac aaaa 24 <210> 693 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 693 uaacugacaa gccagggaca aaac 24 <210> 694 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 694 ucccuggcuu gucaguuaca agua 24 <210> 695 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 695 cagaguaaca gucugaguag gagc 24 <210> 696 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 696 uacuuuguuu agcaauacau ggua 24 <210> 697 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 697 uggcucaaau uguuacucuu caau 24 <210> 698 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 698 cuuucaaaga acuuugcaga gccu 24 <210> 699 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 699 guugaagcca uuuuguugcu cuuu 24 <210> 700 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 700 guugaagcca uuuuauugcu cuuu 24 <210> 701 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 701 uuuugaggcu cugcaaaguu cuuu 24 <210> 702 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 702 aguuauuaau gcauagauau ucag 24 <210> 703 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 703 uauaauaugc ccuguaauau aaua 24 <210> 704 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 704 uaaaggccaa accucggcuu accu 24 <210> 705 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 705 ucaauaucuu ugaaggacuc uggg 24 <210> 706 <211> 19 <212> DNA <213> Mus musculus <400> 706 agagtaacag tctgactgg 19 <210> 707 <211> 19 <212> DNA <213> Mus musculus <400> 707 gaaatgatca tcaaacaga 19 <210> 708 <211> 20 <212> DNA <213> Mus musculus <400> 708 cactagagta acagtctgac 20 <210> 709 <211> 19 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 709 ccagucagac uguuacucu 19 <210> 710 <211> 19 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 710 ucuguuugau gaucauuuc 19 <210> 711 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 711 gucagacugu uacucuagug 20 <210> 712 <211> 19 <212> DNA <213> Homo sapiens <400> 712 agagtaacag tctgagtag 19 <210> 713 <211> 19 <212> DNA <213> Homo sapiens <400> 713 gagatgatca tcaagcaga 19 <210> 714 <211> 20 <212> DNA <213> Homo sapiens <400> 714 caccagagta acagtctgag 20 <210> 715 <211> 19 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 715 cuacucagac uguuacucu 19 <210> 716 <211> 19 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 716 ucugcuugau gaucaucuc 19 <210> 717 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 717 cucagacugu uacucuggug 20 <210> 718 <211> 20 <212> DNA <213> Homo sapiens <400> 718 caccagagta acagtctgag 20 <210> 719 <211> 20 <212> DNA <213> Homo sapiens <400> 719 tattttgggt ttttgcaaaa 20 <210> 720 <211> 20 <212> DNA <213> Homo sapiens <400> 720 agtaggagct aaaatatttt 20 <210> 721 <211> 20 <212> DNA <213> Homo sapiens <400> 721 gagtaggagc taaaatattt 20 <210> 722 <211> 20 <212> DNA <213> Homo sapiens <400> 722 accagagtaa cagtctgagt 20 <210> 723 <211> 20 <212> DNA <213> Homo sapiens <400> 723 tcctactcag actgttactc 20 <210> 724 <211> 20 <212> DNA <213> Homo sapiens <400> 724 tactctggtg acacaacctg 20 <210> 725 <211> 20 <212> DNA <213> Homo sapiens <400> 725 gcagtttcct tagtaaccac 20 <210> 726 <211> 20 <212> DNA <213> Homo sapiens <400> 726 gacacaacct gtggttacta 20 <210> 727 <211> 20 <212> DNA <213> Homo sapiens <400> 727 tgtcaccaga gtaacagtct 20 <210> 728 <211> 20 <212> DNA <213> Homo sapiens <400> 728 aggttgtgtc accagagtaa 20 <210> 729 <211> 20 <212> DNA <213> Homo sapiens <400> 729 aaccacaggt tgtgtcacca 20 <210> 730 <211> 20 <212> DNA <213> Homo sapiens <400> 730 gtaaccacag gttgtgtcac 20 <210> 731 <211> 20 <212> DNA <213> Homo sapiens <400> 731 atttattttt ccttttattc 20 <210> 732 <211> 20 <212> DNA <213> Homo sapiens <400> 732 tttcctttta ttctagttga 20 <210> 733 <211> 20 <212> DNA <213> Homo sapiens <400> 733 tgattctgaa ttctttcaac 20 <210> 734 <211> 20 <212> DNA <213> Homo sapiens <400> 734 aattctttca actagaataa 20 <210> 735 <211> 20 <212> DNA <213> Homo sapiens <400> 735 ttattctagt tgaaagaatt 20 <210> 736 <211> 20 <212> DNA <213> Homo sapiens <400> 736 tagttgaaag aattcagaat 20 <210> 737 <211> 20 <212> DNA <213> Homo sapiens <400> 737 aattcagaat cagtgggatg 20 <210> 738 <211> 20 <212> DNA <213> Homo sapiens <400> 738 attctttcaa ctagaataaa 20 <210> 739 <211> 20 <212> DNA <213> Homo sapiens <400> 739 ttgaaagaat tcagaatcag 20 <210> 740 <211> 20 <212> DNA <213> Homo sapiens <400> 740 tgaaagaatt cagaatcagt 20 <210> 741 <211> 20 <212> DNA <213> Homo sapiens <400> 741 actgttgcct ccggttctga 20 <210> 742 <211> 20 <212> DNA <213> Homo sapiens <400> 742 cagatctgtc aaatcgcctg 20 <210> 743 <211> 20 <212> DNA <213> Homo sapiens <400> 743 aaaacgccgc catttctcaa 20 <210> 744 <211> 20 <212> DNA <213> Homo sapiens <400> 744 agatctgtca aatcgcctgc 20 <210> 745 <211> 20 <212> DNA <213> Homo sapiens <400> 745 tatggatcaa gaaaaataga 20 <210> 746 <211> 20 <212> DNA <213> Homo sapiens <400> 746 cgcctgcagg taaaagcata 20 <210> 747 <211> 20 <212> DNA <213> Homo sapiens <400> 747 atccatatgc ttttacctgc 20 <210> 748 <211> 20 <212> DNA <213> Homo sapiens <400> 748 ttgacagatc tgttgagaaa 20 <210> 749 <211> 20 <212> DNA <213> Homo sapiens <400> 749 acagatctgt tgagaaatgg 20 <210> 750 <211> 20 <212> DNA <213> Homo sapiens <400> 750 ggcgatttga cagatctgtt 20 <210> 751 <211> 20 <212> DNA <213> Homo sapiens <400> 751 ggcgttttca ttatgatata 20 <210> 752 <211> 20 <212> DNA <213> Homo sapiens <400> 752 atgatataaa gatatttaat 20 <210> 753 <211> 20 <212> DNA <213> Homo sapiens <400> 753 gatatttaat cagtggctaa 20 <210> 754 <211> 20 <212> DNA <213> Homo sapiens <400> 754 atttaatcag tggctaacag 20 <210> 755 <211> 20 <212> DNA <213> Homo sapiens <400> 755 agaaactgtt cagcttctgt 20 <210> 756 <211> 20 <212> DNA <213> Homo sapiens <400> 756 gttttaaaat ttttatatta 20 <210> 757 <211> 20 <212> DNA <213> Homo sapiens <400> 757 ttttatatta cagaatataa 20 <210> 758 <211> 20 <212> DNA <213> Homo sapiens <400> 758 atattacaga atataaaaga 20 <210> 759 <211> 20 <212> DNA <213> Homo sapiens <400> 759 gttcctgtaa gataccaaaa 20 <210> 760 <211> 20 <212> DNA <213> Homo sapiens <400> 760 ttgccttttt ggtatcttac 20 <210> 761 <211> 20 <212> DNA <213> Homo sapiens <400> 761 tggtatctta caggaactcc 20 <210> 762 <211> 20 <212> DNA <213> Homo sapiens <400> 762 atcttacagg aactccagga 20 <210> 763 <211> 20 <212> DNA <213> Homo sapiens <400> 763 gccgctgccc aatgccatcc 20 <210> 764 <211> 20 <212> DNA <213> Homo sapiens <400> 764 caggaactcc aggatggcat 20 <210> 765 <211> 20 <212> DNA <213> Homo sapiens <400> 765 aggaactcca ggatggcatt 20 <210> 766 <211> 20 <212> DNA <213> Homo sapiens <400> 766 tccaggatgg cattgggcag 20 <210> 767 <211> 20 <212> DNA <213> Homo sapiens <400> 767 gtcagaacat tgaatgcaac 20 <210> 768 <211> 20 <212> DNA <213> Homo sapiens <400> 768 agttcctgta agataccaaa 20 <210> 769 <211> 20 <212> DNA <213> Homo sapiens <400> 769 tgccatcctg gagttcctgt 20 <210> 770 <211> 20 <212> DNA <213> Homo sapiens <400> 770 ttggtatctt acaggaactc 20 <210> 771 <211> 20 <212> DNA <213> Homo sapiens <400> 771 cgctgcccaa tgccatcctg 20 <210> 772 <211> 20 <212> DNA <213> Homo sapiens <400> 772 aactccagga tggcattggg 20 <210> 773 <211> 20 <212> DNA <213> Homo sapiens <400> 773 gggcagcggc aaactgttgt 20 <210> 774 <211> 20 <212> DNA <213> Homo sapiens <400> 774 agatctgtca aatcgcctgc 20 <210> 775 <211> 20 <212> DNA <213> Homo sapiens <400> 775 aatcctgcat tgttgcctgt 20 <210> 776 <211> 20 <212> DNA <213> Homo sapiens <400> 776 cgctgaagaa ccctgatact 20 <210> 777 <211> 20 <212> DNA <213> Homo sapiens <400> 777 gaacaaatat cccttagtat 20 <210> 778 <211> 20 <212> DNA <213> Homo sapiens <400> 778 ctgtaagaac aaatatccct 20 <210> 779 <211> 20 <212> DNA <213> Homo sapiens <400> 779 ctaagggata tttgttctta 20 <210> 780 <211> 20 <212> DNA <213> Homo sapiens <400> 780 tgttcttaca ggcaacaatg 20 <210> 781 <211> 20 <212> DNA <213> Homo sapiens <400> 781 caacaatgca ggatttggaa 20 <210> 782 <211> 20 <212> DNA <213> Homo sapiens <400> 782 acaatgcagg atttggaaca 20 <210> 783 <211> 20 <212> DNA <213> Homo sapiens <400> 783 atttggaaca gaggcgtccc 20 <210> 784 <211> 20 <212> DNA <213> Homo sapiens <400> 784 acagaggcgt ccccagttgg 20 <210> 785 <211> 20 <212> DNA <213> Homo sapiens <400> 785 tattttttta ttttgcattt 20 <210> 786 <211> 20 <212> DNA <213> Homo sapiens <400> 786 ttattttgca ttttagatga 20 <210> 787 <211> 20 <212> DNA <213> Homo sapiens <400> 787 attttgcatt ttagatgaaa 20 <210> 788 <211> 20 <212> DNA <213> Homo sapiens <400> 788 ttgcatttta gatgaaagag 20 <210> 789 <211> 20 <212> DNA <213> Homo sapiens <400> 789 atgaaagaga agatgttcaa 20 <210> 790 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 790 cuacucagac uguuacucug 20 <210> 791 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 791 cucagacugu uacucuggug 20 <210> 792 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 792 uuuugcaaaa acccaaaaua 20 <210> 793 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 793 aaaauauuuu agcuccuacu 20 <210> 794 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 794 aaauauuuua gcuccuacuc 20 <210> 795 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 795 acucagacug uuacucuggu 20 <210> 796 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 796 gaguaacagu cugaguagga 20 <210> 797 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 797 cagguugugu caccagagua 20 <210> 798 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 798 gugguuacua aggaaacugc 20 <210> 799 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 799 uaguaaccac agguuguguc 20 <210> 800 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 800 agacuguuac ucuggugaca 20 <210> 801 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 801 uuacucuggu gacacaaccu 20 <210> 802 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 802 uggugacaca accugugguu 20 <210> 803 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 803 gugacacaac cugugguuac 20 <210> 804 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 804 gaauaaaagg aaaaauaaau 20 <210> 805 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 805 ucaacuagaa uaaaaggaaa 20 <210> 806 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 806 guugaaagaa uucagaauca 20 <210> 807 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 807 uuauucuagu ugaaagaauu 20 <210> 808 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 808 aauucuuuca acuagaauaa 20 <210> 809 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 809 auucugaauu cuuucaacua 20 <210> 810 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 810 caucccacug auucugaauu 20 <210> 811 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 811 uuuauucuag uugaaagaau 20 <210> 812 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 812 cugauucuga auucuuucaa 20 <210> 813 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 813 acugauucug aauucuuuca 20 <210> 814 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 814 ucagaaccgg aggcaacagu 20 <210> 815 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 815 caggcgauuu gacagaucug 20 <210> 816 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 816 uugagaaaug gcggcguuuu 20 <210> 817 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 817 gcaggcgauu ugacagaucu 20 <210> 818 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 818 ucuauuuuuc uugauccaua 20 <210> 819 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 819 uaugcuuuua ccugcaggcg 20 <210> 820 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 820 gcagguaaaa gcauauggau 20 <210> 821 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 821 uuucucaaca gaucugucaa 20 <210> 822 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 822 ccauuucuca acagaucugu 20 <210> 823 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 823 aacagaucug ucaaaucgcc 20 <210> 824 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 824 uauaucauaa ugaaaacgcc 20 <210> 825 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 825 auuaaauauc uuuauaucau 20 <210> 826 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 826 uuagccacug auuaaauauc 20 <210> 827 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 827 cuguuagcca cugauuaaau 20 <210> 828 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 828 acagaagcug aacaguuucu 20 <210> 829 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 829 uaauauaaaa auuuuaaaac 20 <210> 830 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 830 uuauauucug uaauauaaaa 20 <210> 831 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 831 ucuuuuauau ucuguaauau 20 <210> 832 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 832 uuuugguauc uuacaggaac 20 <210> 833 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 833 guaagauacc aaaaaggcaa 20 <210> 834 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 834 ggaguuccug uaagauacca 20 <210> 835 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 835 uccuggaguu ccuguaagau 20 <210> 836 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 836 ggauggcauu gggcagcggc 20 <210> 837 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 837 augccauccu ggaguuccug 20 <210> 838 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 838 aaugccaucc uggaguuccu 20 <210> 839 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 839 cugcccaaug ccauccugga 20 <210> 840 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 840 guugcauuca auguucugac 20 <210> 841 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 841 uuugguaucu uacaggaacu 20 <210> 842 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 842 acaggaacuc caggauggca 20 <210> 843 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 843 gaguuccugu aagauaccaa 20 <210> 844 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 844 caggauggca uugggcagcg 20 <210> 845 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 845 cccaaugcca uccuggaguu 20 <210> 846 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 846 acaacaguuu gccgcugccc 20 <210> 847 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 847 gcaggcgauu ugacagaucu 20 <210> 848 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 848 acaggcaaca augcaggauu 20 <210> 849 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 849 aguaucaggg uucuucagcg 20 <210> 850 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 850 auacuaaggg auauuuguuc 20 <210> 851 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 851 agggauauuu guucuuacag 20 <210> 852 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 852 uaagaacaaa uaucccuuag 20 <210> 853 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 853 cauuguugcc uguaagaaca 20 <210> 854 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 854 uuccaaaucc ugcauuguug 20 <210> 855 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 855 uguuccaaau ccugcauugu 20 <210> 856 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 856 gggacgccuc uguuccaaau 20 <210> 857 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 857 ccaacugggg acgccucugu 20 <210> 858 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 858 acagaggcgu ccccaguugg 20 <210> 859 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 859 ucaucuaaaa ugcaaaauaa 20 <210> 860 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 860 uuucaucuaa aaugcaaaau 20 <210> 861 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 861 cucuuucauc uaaaaugcaa 20 <210> 862 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 862 uugaacaucu ucucuuucau 20 <210> 863 <211> 20 <212> DNA <213> Canis lupus familiaris <400> 863 caccagagta acagtctgac 20 <210> 864 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 864 gucagacugu uacucuggug 20 <210> 865 <211> 8969 <212> DNA <213> Homo sapiens <400> 865 actttccccc tacaggactc agatctggga ggcaattacc ttcggagaaa aacgaatagg 60 aaaaactgaa gtgttacttt ttttaaagct gctgaagttt gttggtttct cattgttttt 120 aagcctactg gagcaataaa gtttgaagaa cttttaccag gtttttttta tcgctgcctt 180 gatatacact tttcaaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag 240 atgttcaaaa gaaaacattc acaaaatggg taaatgcaca attttctaag tttgggaagc 300 agcatattga gaacctcttc agtgacctac aggatgggag gcgcctccta gacctcctcg 360 aaggcctgac agggcaaaaa ctgccaaaag aaaaaggatc cacaagagtt catgccctga 420 acaatgtcaa caaggcactg cgggttttgc agaacaataa tgttgattta gtgaatattg 480 gaagtactga catcgtagat ggaaatcata aactgactct tggtttgatt tggaatataa 540 tcctccactg gcaggtcaaa aatgtaatga aaaatatcat ggctggattg caacaaacca 600 acagtgaaaa gattctcctg agctgggtcc gacaatcaac tcgtaattat ccacaggtta 660 atgtaatcaa cttcaccacc agctggtctg atggcctggc tttgaatgct ctcatccata 720 gtcataggcc agacctattt gactggaata gtgtggtttg ccagcagtca gccacacaac 780 gactggaaca tgcattcaac atcgccagat atcaattagg catagagaaa ctactcgatc 840 ctgaagatgt tgataccacc tatccagata agaagtccat cttaatgtac atcacatcac 900 tcttccaagt tttgcctcaa caagtgagca ttgaagccat ccaggaagtg gaaatgttgc 960 caaggccacc taaagtgact aaagaagaac attttcagtt acatcatcaa atgcactatt 1020 ctcaacagat cacggtcagt ctagcacagg gatatgagag aacttcttcc cctaagcctc 1080 gattcaagag ctatgcctac acacaggctg cttatgtcac cacctctgac cctacacgga 1140 gcccatttcc ttcacagcat ttggaagctc ctgaagacaa gtcatttggc agttcattga 1200 tggagagtga agtaaacctg gaccgttatc aaacagcttt agaagaagta ttatcgtggc 1260 ttctttctgc tgaggacaca ttgcaagcac aaggagagat ttctaatgat gtggaagtgg 1320 tgaaagacca gtttcatact catgaggggt acatgatgga tttgacagcc catcagggcc 1380 gggttggtaa tattctacaa ttgggaagta agctgattgg aacaggaaaa ttatcagaag 1440 atgaagaaac tgaagtacaa gagcagatga atctcctaaa ttcaagatgg gaatgcctca 1500 gggtagctag catggaaaaa caaagcaatt tacatagagt tttaatggat ctccagaatc 1560 agaaactgaa agagttgaat gactggctaa caaaaacaga agaaagaaca aggaaaatgg 1620 aggaagagcc tcttggacct gatcttgaag acctaaaacg ccaagtacaa caacataagg 1680 tgcttcaaga agatctagaa caagaacaag tcagggtcaa ttctctcact cacatggtgg 1740 tggtagttga tgaatctagt ggagatcacg caactgctgc tttggaagaa caacttaagg 1800 tattgggaga tcgatgggca aacatctgta gatggacaga agaccgctgg gttcttttac 1860 aagacatcct tctcaaatgg caacgtctta ctgaagaaca gtgccttttt agtgcatggc 1920 tttcagaaaa agaagatgca gtgaacaaga ttcacacaac tggctttaaa gatcaaaatg 1980 aaatgttatc aagtcttcaa aaactggccg ttttaaaagc ggatctagaa aagaaaaagc 2040 aatccatggg caaactgtat tcactcaaac aagatcttct ttcaacactg aagaataagt 2100 cagtgaccca gaagacggaa gcatggctgg ataactttgc ccggtgttgg gataatttag 2160 tccaaaaact tgaaaagagt acagcacaga tttcacaggc tgtcaccacc actcagccat 2220 cactaacaca gacaactgta atggaaacag taactacggt gaccacaagg gaacagatcc 2280 tggtaaagca tgctcaagag gaacttccac caccacctcc ccaaaagaag aggcagatta 2340 ctgtggattc tgaaattagg aaaaggttgg atgttgatat aactgaactt cacagctgga 2400 ttactcgctc agaagctgtg ttgcagagtc ctgaatttgc aatctttcgg aaggaaggca 2460 acttctcaga cttaaaagaa aaagtcaatg ccatagagcg agaaaaagct gagaagttca 2520 gaaaactgca agatgccagc agatcagctc aggccctggt ggaacagatg gtgaatgagg 2580 gtgttaatgc agatagcatc aaacaagcct cagaacaact gaacagccgg tggatcgaat 2640 tctgccagtt gctaagtgag agacttaact ggctggagta tcagaacaac atcatcgctt 2700 tctataatca gctacaacaa ttggagcaga tgacaactac tgctgaaaac tggttgaaaa 2760 tccaacccac caccccatca gagccaacag caattaaaag tcagttaaaa atttgtaagg 2820 atgaagtcaa ccggctatca gatcttcaac ctcaaattga acgattaaaa attcaaagca 2880 tagccctgaa agagaaagga caaggaccca tgttcctgga tgcagacttt gtggccttta 2940 caaatcattt taagcaagtc ttttctgatg tgcaggccag agagaaagag ctacagacaa 3000 tttttgacac tttgccacca atgcgctatc aggagaccat gagtgccatc aggacatggg 3060 tccagcagtc agaaaccaaa ctctccatac ctcaacttag tgtcaccgac tatgaaatca 3120 tggagcagag actcggggaa ttgcaggctt tacaaagttc tctgcaagag caacaaagtg 3180 gcctatacta tctcagcacc actgtgaaag agatgtcgaa gaaagcgccc tctgaaatta 3240 gccggaaata tcaatcagaa tttgaagaaa ttgagggacg ctggaagaag ctctcctccc 3300 agctggttga gcattgtcaa aagctagagg agcaaatgaa taaactccga aaaattcaga 3360 atcacataca aaccctgaag aaatggatgg ctgaagttga tgtttttctg aaggaggaat 3420 ggcctgccct tggggattca gaaattctaa aaaagcagct gaaacagtgc agacttttag 3480 tcagtgatat tcagacaatt cagcccagtc taaacagtgt caatgaaggt gggcagaaga 3540 taaagaatga agcagagcca gagtttgctt cgagacttga gacagaactc aaagaactta 3600 acactcagtg ggatcacatg tgccaacagg tctatgccag aaaggaggcc ttgaagggag 3660 gtttggagaa aactgtaagc ctccagaaag atctatcaga gatgcacgaa tggatgacac 3720 aagctgaaga agagtatctt gagagagatt ttgaatataa aactccagat gaattacaga 3780 aagcagttga agagatgaag agagctaaag aagaggccca acaaaaagaa gcgaaagtga 3840 aactccttac tgagtctgta aatagtgtca tagctcaagc tccacctgta gcacaagagg 3900 ccttaaaaaa ggaacttgaa actctaacca ccaactacca gtggctctgc actaggctga 3960 atgggaaatg caagactttg gaagaagttt gggcatgttg gcatgagtta ttgtcatact 4020 tggagaaagc aaacaagtgg ctaaatgaag tagaatttaa acttaaaacc actgaaaaca 4080 ttcctggcgg agctgaggaa atctctgagg tgctagattc acttgaaaat ttgatgcgac 4140 attcagagga taacccaaat cagattcgca tattggcaca gaccctaaca gatggcggag 4200 tcatggatga gctaatcaat gaggaacttg agacatttaa ttctcgttgg agggaactac 4260 atgaagaggc tgtaaggagg caaaagttgc ttgaacagag catccagtct gcccaggaga 4320 ctgaaaaatc cttacactta atccaggagt ccctcacatt cattgacaag cagttggcag 4380 cttatattgc agacaaggtg gacgcagctc aaatgcctca ggaagcccag aaaatccaat 4440 ctgatttgac aagtcatgag atcagtttag aagaaatgaa gaaacataat caggggaagg 4500 aggctgccca aagagtcctg tctcagattg atgttgcaca gaaaaaatta caagatgtct 4560 ccatgaagtt tcgattattc cagaaaccag ccaattttga gcagcgtcta caagaaagta 4620 agatgatttt agatgaagtg aagatgcact tgcctgcatt ggaaacaaag agtgtggaac 4680 aggaagtagt acagtcacag ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag 4740 tgaagtctga agtggaaatg gtgataaaga ctggacgtca gattgtacag aaaaagcaga 4800 cggaaaatcc caaagaactt gatgaaagag taacagcttt gaaattgcat tataatgagc 4860 tgggagcaaa ggtaacagaa agaaagcaac agttggagaa atgcttgaaa ttgtcccgta 4920 agatgcgaaa ggaaatgaat gtcttgacag aatggctggc agctacagat atggaattga 4980 caaagagatc agcagttgaa ggaatgccta gtaatttgga ttctgaagtt gcctggggaa 5040 aggctactca aaaagagatt gagaaacaga aggtgcacct gaagagtatc acagaggtag 5100 gagaggcctt gaaaacagtt ttgggcaaga aggagacgtt ggtggaagat aaactcagtc 5160 ttctgaatag taactggata gctgtcacct cccgagcaga agagtggtta aatcttttgt 5220 tggaatacca gaaacacatg gaaacttttg accagaatgt ggaccacatc acaaagtgga 5280 tcattcaggc tgacacactt ttggatgaat cagagaaaaa gaaaccccag caaaaagaag 5340 acgtgcttaa gcgtttaaag gcagaactga atgacatacg cccaaaggtg gactctacac 5400 gtgaccaagc agcaaacttg atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc 5460 cccaaatctc agagctcaac catcgatttg cagccatttc acacagaatt aagactggaa 5520 aggcctccat tcctttgaag gaattggagc agtttaactc agatatacaa aaattgcttg 5580 aaccactgga ggctgaaatt cagcaggggg tgaatctgaa agaggaagac ttcaataaag 5640 atatgaatga agacaatgag ggtactgtaa aagaattgtt gcaaagagga gacaacttac 5700 aacaaagaat cacagatgag agaaagcgag aggaaataaa gataaaacag cagctgttac 5760 agacaaaaca taatgctctc aaggatttga ggtctcaaag aagaaaaaag gctctagaaa 5820 tttctcatca gtggtatcag tacaagaggc aggctgatga tctcctgaaa tgcttggatg 5880 acattgaaaa aaaattagcc agcctacctg agcccagaga tgaaaggaaa ataaaggaaa 5940 ttgatcggga attgcagaag aagaaagagg agctgaatgc agtgcgtagg caagctgagg 6000 gcttgtctga ggatggggcc gcaatggcag tggagccaac tcagatccag ctcagcaagc 6060 gctggcggga aattgagagc aaatttgctc agtttcgaag actcaacttt gcacaaattc 6120 acactgtccg tgaagaaacg atgatggtga tgactgaaga catgcctttg gaaatttctt 6180 atgtgccttc tacttatttg actgaaatca ctcatgtctc acaagcccta ttagaagtgg 6240 aacaacttct caatgctcct gacctctgtg ctaaggactt tgaagatctc tttaagcaag 6300 aggagtctct gaagaatata aaagatagtc tacaacaaag ctcaggtcgg attgacatta 6360 ttcatagcaa gaagacagca gcattgcaaa gtgcaacgcc tgtggaaagg gtgaagctac 6420 aggaagctct ctcccagctt gatttccaat gggaaaaagt taacaaaatg tacaaggacc 6480 gacaagggcg atttgacaga tctgttgaga aatggcggcg ttttcattat gatataaaga 6540 tatttaatca gtggctaaca gaagctgaac agtttctcag aaagacacaa attcctgaga 6600 attgggaaca tgctaaatac aaatggtatc ttaagatctc cgagaggcag aaaaagggga 6660 actgtgcaac ccttttgtcc ttctggatct caaaatgaag ggatacattc tgctacatga 6720 aatgtggaat taagaccatg atgcaacatg ataaacaaca caaatttggg ggtgtctctg 6780 tgctatacat tattgaattt ttccatgcta tacacttttt ggatgtgtct gtgctattta 6840 ttcagttttt ttaaataaaa gtttttgtag actaaattgc cctctctact ttgcatcgtt 6900 tttgaacaaa ggattttcaa gactgataag ctcaaatgta tcatttattg tattcaagta 6960 gcattcaatt tttctttaga agtataattt gtagatattt taacacagaa aacttgcaac 7020 actgctcatg ataggcactt attatatatt ttttgaaaga ctatatggat aatgattcta 7080 actttgactt ttcctgtttt gccttcactt tagaattaag cagagaatca aatccatatt 7140 cctgggggcg atgcttggac aacagtatct ctttaaagat ctttgtgtga gtcgaaggtg 7200 cagccagact gggagttatt gtgaagaaac agattcagga aggttgagaa acttgcctaa 7260 ggctaatcag atagttactg gcaatgttgt ttctaaatca ctgtttggct ccctcattca 7320 atgaatctac actatgtggg actgcctctt gctcctgaca tcttttgctg ctgaaataaa 7380 tgaactcaaa gcctagaagg tagaaaagag ggagttcaga attatattca ggcacaaata 7440 ccaataaggc tattgccccc agaactgcaa cttctcttgg tttaacagat aactatttag 7500 ctgtgaggta caactgagga agtggacaca caagttatca ggagattctg atgtgccagt 7560 ttatatttct tgtcacaggt aatgattcga aatttcttaa aacagctgtc ctcacagtgg 7620 agtaacctgg gagtacatga aggcattcca aggagtaggc acagatagtt ttaagggaat 7680 ttatttctag atcttctact ttattttgta ctcttcctga aaactgaatt gcctgaaaaa 7740 aaaaaaaaaa aaaaaaagac atctgtagtc aagacctcag gctgtttctc ctttctaacc 7800 acttgccttt tctaaccact tctcccaatt taagaaaaaa agccttatat ttcatccaac 7860 tctgatctta ctaaggcttc aaacaaaaga agcatgaatg actttcatga cagggcaaca 7920 tagctttttg caagaagagt ggttgctaac tctttgcttt caactgaacc cgaagagaag 7980 acctgataag ttgtcagccg atagatcatt aaaaatacgt tttggtaagc aatcatcatg 8040 tacttttagc atatgccata gcaggagcac aaatgattaa gcaatgctac tataatacaa 8100 ttccttccgt ttctttctac tcacctattt gaataagatt tttcatcatt tacatctata 8160 cagacaaaaa ttagggatag aattgatgct gaagcctttc caattgtaga attaatttat 8220 attcttctga aggtgtataa attgttaaat acccatccat cttattaaga gatgtatttt 8280 caataaaatt ttatttttat gtttatcaaa ttttataata tacatatatt gttttggtca 8340 attgcacgtt aataattgta acaatacctc aattgaaaag gtttgttttt tacatttagg 8400 acttacagta acagaaaaaa aacactcatt gtgtatacat actgtttaag aaaagtatac 8460 taggtgatca ataagatttt ttcaggcata aacatatatc ttagttttaa gatatcgata 8520 tttacaatgt ccctcaaatt atattatttt cagtcattta agaatgaaaa gtacatttcg 8580 aatgcggatt ttaaatctgc aagggttgac tcatttttca agagtctttt taggggatac 8640 agaagcaaga atgtttggag ttccctgatc agtatcttta agagaaggta tttgttggta 8700 gttcctagca aattccaaca gcctgatgct acttaaaaga taatagtaat tattttaaat 8760 aatgcttctg ataaaaaaca ttcatgcaca ctcagtttaa aaagatattt aaacatttgt 8820 agttgtagtt tgggaactca tgatacaagt acagtctgta aatgaagctc ttagtttgca 8880 aatatcagag ataagctatt aaaatgcaga aattgaaatt gccctgatat atgcataaat 8940 tagtgtcatc tccatcttgt cagttagag 8969 <210> 866 <211> 2166 <212> PRT <213> Homo sapiens <400> 866 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser 1775 1780 1785 Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln 1790 1795 1800 Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu 1805 1810 1815 Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn 1820 1825 1830 Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys 1835 1840 1845 Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp 1850 1855 1860 Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln 1865 1870 1875 Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu 1880 1885 1890 Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp 1895 1900 1905 Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys 1910 1915 1920 Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu 1925 1930 1935 Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser 1940 1945 1950 Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg 1955 1960 1965 Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met 1970 1975 1980 Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser 1985 1990 1995 Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu 2000 2005 2010 Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe 2015 2020 2025 Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp 2030 2035 2040 Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys 2045 2050 2055 Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 2060 2065 2070 Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val 2075 2080 2085 Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 2090 2095 2100 Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 2105 2110 2115 Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro 2120 2125 2130 Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Ile Ser 2135 2140 2145 Glu Arg Gln Lys Lys Gly Asn Cys Ala Thr Leu Leu Ser Phe Trp 2150 2155 2160 Ile Ser Lys 2165 <210> 867 <211> 6156 <212> DNA <213> Homo sapiens <400> 867 actttccccc tacaggactc agatctggga ggcaattacc ttcggagaaa aacgaatagg 60 aaaaactgaa gtgttacttt ttttaaagct gctgaagttt gttggtttct cattgttttt 120 aagcctactg gagcaataaa gtttgaagaa cttttaccag gtttttttta tcgctgcctt 180 gatatacact tttcaaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag 240 atgttcaaaa gaaaacattc acaaaatggg taaatgcaca attttctaag tttgggaagc 300 agcatattga gaacctcttc agtgacctac aggatgggag gcgcctccta gacctcctcg 360 aaggcctgac agggcaaaaa ctgccaaaag aaaaaggatc cacaagagtt catgccctga 420 acaatgtcaa caaggcactg cgggttttgc agaacaataa tgttgattta gtgaatattg 480 gaagtactga catcgtagat ggaaatcata aactgactct tggtttgatt tggaatataa 540 tcctccactg gcaggtcaaa aatgtaatga aaaatatcat ggctggattg caacaaacca 600 acagtgaaaa gattctcctg agctgggtcc gacaatcaac tcgtaattat ccacaggtta 660 atgtaatcaa cttcaccacc agctggtctg atggcctggc tttgaatgct ctcatccata 720 gtcataggcc agacctattt gactggaata gtgtggtttg ccagcagtca gccacacaac 780 gactggaaca tgcattcaac atcgccagat atcaattagg catagagaaa ctactcgatc 840 ctgaagatgt tgataccacc tatccagata agaagtccat cttaatgtac atcacatcac 900 tcttccaagt tttgcctcaa caagtgagca ttgaagccat ccaggaagtg gaaatgttgc 960 caaggccacc taaagtgact aaagaagaac attttcagtt acatcatcaa atgcactatt 1020 ctcaacagat cacggtcagt ctagcacagg gatatgagag aacttcttcc cctaagcctc 1080 gattcaagag ctatgcctac acacaggctg cttatgtcac cacctctgac cctacacgga 1140 gcccatttcc ttcacagcat ttggaagctc ctgaagacaa gtcatttggc agttcattga 1200 tggagagtga agtaaacctg gaccgttatc aaacagcttt agaagaagta ttatcgtggc 1260 ttctttctgc tgaggacaca ttgcaagcac aaggagagat ttctaatgat gtggaagtgg 1320 tgaaagacca gtttcatact catgaggggt acatgatgga tttgacagcc catcagggcc 1380 gggttggtaa tattctacaa ttgggaagta agctgattgg aacaggaaaa ttatcagaag 1440 atgaagaaac tgaagtacaa gagcagatga atctcctaaa ttcaagatgg gaatgcctca 1500 gggtagctag catggaaaaa caaagcaatt tacatagagt tttaatggat ctccagaatc 1560 agaaactgaa agagttgaat gactggctaa caaaaacaga agaaagaaca aggaaaatgg 1620 aggaagagcc tcttggacct gatcttgaag acctaaaacg ccaagtacaa caacataagg 1680 tgcttcaaga agatctagaa caagaacaag tcagggtcaa ttctctcact cacatggtgg 1740 tggtagttga tgaatctagt ggagatcacg caactgctgc tttggaagaa caacttaagg 1800 tattgggaga tcgatgggca aacatctgta gatggacaga agaccgctgg gttcttttac 1860 aagacatcct tctcaaatgg caacgtctta ctgaagaaca gtgccttttt agtgcatggc 1920 tttcagaaaa agaagatgca gtgaacaaga ttcacacaac tggctttaaa gatcaaaatg 1980 aaatgttatc aagtcttcaa aaactggccg ttttaaaagc ggatctagaa aagaaaaagc 2040 aatccatggg caaactgtat tcactcaaac aagatcttct ttcaacactg aagaataagt 2100 cagtgaccca gaagacggaa gcatggctgg ataactttgc ccggtgttgg gataatttag 2160 tccaaaaact tgaaaagagt acagcacaga tttcacaggc tgtcaccacc actcagccat 2220 cactaacaca gacaactgta atggaaacag taactacggt gaccacaagg gaacagatcc 2280 tggtaaagca tgctcaagag gaacttccac caccacctcc ccaaaagaag aggcagatta 2340 ctgtggattc tgaaattagg aaaaggttgg atgttgatat aactgaactt cacagctgga 2400 ttactcgctc agaagctgtg ttgcagagtc ctgaatttgc aatctttcgg aaggaaggca 2460 acttctcaga cttaaaagaa aaagtcaatg ccatagagcg agaaaaagct gagaagttca 2520 gaaaactgca agatgccagc agatcagctc aggccctggt ggaacagatg gtgaatgagg 2580 gtgttaatgc agatagcatc aaacaagcct cagaacaact gaacagccgg tggatcgaat 2640 tctgccagtt gctaagtgag agacttaact ggctggagta tcagaacaac atcatcgctt 2700 tctataatca gctacaacaa ttggagcaga tgacaactac tgctgaaaac tggttgaaaa 2760 tccaacccac caccccatca gagccaacag caattaaaag tcagttaaaa atttgtaagg 2820 atgaagtcaa ccggctatca gatcttcaac ctcaaattga acgattaaaa attcaaagca 2880 tagccctgaa agagaaagga caaggaccca tgttcctgga tgcagacttt gtggccttta 2940 caaatcattt taagcaagtc ttttctgatg tgcaggccag agagaaagag ctacagacaa 3000 tttttgacac tttgccacca atgcgctatc aggagaccat gagtgccatc aggacatggg 3060 tccagcagtc agaaaccaaa ctctccatac ctcaacttag tgtcaccgac tatgaaatca 3120 tggagcagag actcggggaa ttgcaggctt tacaaagttc tctgcaagag caacaaagtg 3180 gcctatacta tctcagcacc actgtgaaag agatgtcgaa gaaagcgccc tctgaaatta 3240 gccggaaata tcaatcagaa tttgaagaaa ttgagggacg ctggaagaag ctctcctccc 3300 agctggttga gcattgtcaa aagctagagg agcaaatgaa taaactccga aaaattcaga 3360 atcacataca aaccctgaag aaatggatgg ctgaagttga tgtttttctg aaggaggaat 3420 ggcctgccct tggggattca gaaattctaa aaaagcagct gaaacagtgc agacttttag 3480 tcagtgatat tcagacaatt cagcccagtc taaacagtgt caatgaaggt gggcagaaga 3540 taaagaatga agcagagcca gagtttgctt cgagacttga gacagaactc aaagaactta 3600 acactcagtg ggatcacatg tgccaacagg tctatgccag aaaggaggcc ttgaagggag 3660 gtttggagaa aactgtaagc ctccagaaag atctatcaga gatgcacgaa tggatgacac 3720 aagctgaaga agagtatctt gagagagatt ttgaatataa aactccagat gaattacaga 3780 aagcagttga agagatgaag agagctaaag aagaggccca acaaaaagaa gcgaaagtga 3840 aactccttac tgagtctgta aatagtgtca tagctcaagc tccacctgta gcacaagagg 3900 ccttaaaaaa ggaacttgaa actctaacca ccaactacca gtggctctgc actaggctga 3960 atgggaaatg caagactttg gaagaagttt gggcatgttg gcatgagtta ttgtcatact 4020 tggagaaagc aaacaagtgg ctaaatgaag tagaatttaa acttaaaacc actgaaaaca 4080 ttcctggcgg agctgaggaa atctctgagg tgctagattc acttgaaaat ttgatgcgac 4140 attcagagga taacccaaat cagattcgca tattggcaca gaccctaaca gatggcggag 4200 tcatggatga gctaatcaat gaggaacttg agacatttaa ttctcgttgg agggaactac 4260 atgaagaggc tgtaaggagg caaaagttgc ttgaacagag catccagtct gcccaggaga 4320 ctgaaaaatc cttacactta atccaggagt ccctcacatt cattgacaag cagttggcag 4380 cttatattgc agacaaggtg gacgcagctc aaatgcctca ggaagcccag aaaatccaat 4440 ctgatttgac aagtcatgag atcagtttag aagaaatgaa gaaacataat caggggaagg 4500 aggctgccca aagagtcctg tctcagattg atgttgcaca gaaaaaatta caagatgtct 4560 ccatgaagtt tcgattattc cagaaaccag ccaattttga gcagcgtcta caagaaagta 4620 agatgatttt agatgaagtg aagatgcact tgcctgcatt ggaaacaaag agtgtggaac 4680 aggaagtagt acagtcacag ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag 4740 tgaagtctga agtggaaatg gtgataaaga ctggacgtca gattgtacag aaaaagcaga 4800 cggaaaatcc caaagaactt gatgaaagag taacagcttt gaaattgcat tataatgagc 4860 tgggagcaaa ggtaacagaa agaaagcaac agttggagaa atgcttgaaa ttgtcccgta 4920 agatgcgaaa ggaaatgaat gtcttgacag aatggctggc agctacagat atggaattga 4980 caaagagatc agcagttgaa ggaatgccta gtaatttgga ttctgaagtt gcctggggaa 5040 aggctactca aaaagagatt gagaaacaga aggtgcacct gaagagtatc acagaggtag 5100 gagaggcctt gaaaacagtt ttgggcaaga aggagacgtt ggtggaagat aaactcagtc 5160 ttctgaatag taactggata gctgtcacct cccgagcaga agagtggtta aatcttttgt 5220 tggaatacca gaaacacatg gaaacttttg accagaatgt ggaccacatc acaaagtgga 5280 tcattcaggc tgacacactt ttggatgaat cagagaaaaa gaaaccccag caaaaagaag 5340 acgtgcttaa gcgtttaaag gcagaactga atgacatacg cccaaaggtg gactctacac 5400 gtgaccaagc agcaaacttg atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc 5460 cccaaatctc agagctcaac catcgatttg cagccatttc acacagaatt aagactggaa 5520 aggcctccat tcctttgaag gaattggagc agtttaactc agatatacaa aaattgcttg 5580 aaccactgga ggctgaaatt cagcaggggg tgaatctgaa agaggaagac ttcaataaag 5640 atatgaatga agacaatgag ggtactgtaa aagaattgtt gcaaagagga gacaacttac 5700 aacaaagaat cacagatgag agaaagcgag aggaaataaa gataaaacag cagctgttac 5760 agacaaaaca taatgctctc aaggatttga ggtctcaaag aagaaaaaag gctctagaaa 5820 tttctcatca gtggtatcag tacaagaggc aggctgatga tctcctgaaa tgcttggatg 5880 acattgaaaa aaaattagcc agcctacctg agcccagaga tgaaaggaaa ataaagatga 5940 actaatgact tatcggtata tggacgactt cttactcatg ttagcccatt catttcatca 6000 gagcatcttc acacatcagt gttcactctc tatagattta tttgcatatt gtctaaatat 6060 gtttttttct gttattattt tacacttttt attttgcttc attctctgtt gagttcctca 6120 aacctttaaa aaggaaataa ataacttatt cactta 6156 <210> 868 <211> 1915 <212> PRT <213> Homo sapiens <400> 868 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 1 5 10 15 Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 20 25 30 Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 35 40 45 Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 50 55 60 Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 65 70 75 80 Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 85 90 95 Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 100 105 110 Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 115 120 125 Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 130 135 140 Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 145 150 155 160 Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 165 170 175 Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 180 185 190 Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 195 200 205 Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 210 215 220 Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 225 230 235 240 Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 245 250 255 Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 260 265 270 His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 275 280 285 Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 290 295 300 Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 305 310 315 320 His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 325 330 335 Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 340 345 350 Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 355 360 365 Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 370 375 380 Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 385 390 395 400 Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 405 410 415 Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 420 425 430 Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 435 440 445 Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 450 455 460 Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 465 470 475 480 Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 485 490 495 Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 500 505 510 Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 515 520 525 Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 530 535 540 Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 545 550 555 560 Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 565 570 575 Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 580 585 590 Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 595 600 605 Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 610 615 620 Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 625 630 635 640 Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 645 650 655 Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 660 665 670 Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 675 680 685 Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 690 695 700 Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 705 710 715 720 Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 725 730 735 Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 740 745 750 Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 755 760 765 Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 770 775 780 Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 785 790 795 800 Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 805 810 815 Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 820 825 830 Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 835 840 845 Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 850 855 860 Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 865 870 875 880 Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 885 890 895 Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 900 905 910 Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 915 920 925 Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 930 935 940 Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 945 950 955 960 Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 965 970 975 Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 980 985 990 Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys 995 1000 1005 Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu 1010 1015 1020 Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu 1025 1030 1035 His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile 1040 1045 1050 Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp 1055 1060 1065 Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile 1070 1075 1080 Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile 1085 1090 1095 Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln 1100 1105 1110 Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu 1115 1120 1125 Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln 1130 1135 1140 Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys 1145 1150 1155 Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met 1160 1165 1170 Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys 1175 1180 1185 Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 1190 1195 1200 Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr 1205 1210 1215 Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln 1220 1225 1230 Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln 1235 1240 1245 Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu 1250 1255 1260 Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala 1265 1270 1275 Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu 1280 1285 1290 Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser 1295 1300 1305 Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile 1310 1315 1320 Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu 1325 1330 1335 Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu 1340 1345 1350 Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser 1355 1360 1365 Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln 1370 1375 1380 Glu Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala 1385 1390 1395 Asp Lys Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile 1400 1405 1410 Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 1415 1420 1425 Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 1430 1435 1440 Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe 1445 1450 1455 Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu 1460 1465 1470 Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu 1475 1480 1485 Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn 1490 1495 1500 His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu 1505 1510 1515 Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys 1520 1525 1530 Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu 1535 1540 1545 Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys 1550 1555 1560 Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys 1565 1570 1575 Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu 1580 1585 1590 Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp 1595 1600 1605 Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys 1610 1615 1620 Gln Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu 1625 1630 1635 Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu 1640 1645 1650 Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu 1655 1660 1665 Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr 1670 1675 1680 Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile Gln Ala 1685 1690 1695 Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln Lys 1700 1705 1710 Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg 1715 1720 1725 Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala 1730 1735 1740 Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser 1745 1750 1755 Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 1760 1765 1770 Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser 1775 1780 1785 Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln 1790 1795 1800 Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu 1805 1810 1815 Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn 1820 1825 1830 Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys 1835 1840 1845 Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp 1850 1855 1860 Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln 1865 1870 1875 Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu 1880 1885 1890 Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp 1895 1900 1905 Glu Arg Lys Ile Lys Met Asn 1910 1915 <210> 869 <211> 2158 <212> PRT <213> Mus musculus <400> 869 Met Trp Trp Val Asp Cys Tyr Arg Asp Val Lys Lys Thr Thr Lys Trp 1 5 10 15 Asn Ala Ser Lys Gly Lys His Asp Asn Ser Asp Asp Gly Lys Arg Asp 20 25 30 Gly Thr Gly Lys Lys Lys Gly Ser Thr Arg Val His Ala Asn Asn Val 35 40 45 Asn Lys Ala Arg Val Lys Asn Asn Val Asp Val Asn Gly Ser Thr Asp 50 55 60 Val Asp Gly Asn His Lys Thr Gly Trp Asn His Trp Val Lys Asn Val 65 70 75 80 Met Lys Thr Met Ala Gly Thr Asn Ser Lys Ser Trp Val Arg Ser Thr 85 90 95 Arg Asn Tyr Val Asn Val Asn Thr Ser Ser Trp Ser Asp Gly Ala Asn 100 105 110 Ala His Ser His Arg Asp Asp Trp Asn Ser Val Val Ser His Ser Ala 115 120 125 Thr Arg His Ala Asn Ala Lys Cys Gly Lys Asp Asp Val Ala Thr Thr 130 135 140 Tyr Asp Lys Lys Ser Met Tyr Thr Ser Val Val Ser Ala Val Met Arg 145 150 155 160 Thr Ser Ser Lys Val Thr Arg His His His Met His Tyr Ser Thr Val 165 170 175 Ser Ala Gly Tyr Thr Ser Ser Ser Lys Arg Lys Ser Tyr Ala Thr Ala 180 185 190 Ala Tyr Val Ala Thr Ser Asp Ser Thr Ser Tyr Ser His Ala Arg Asp 195 200 205 Lys Ser Asp Ser Ser Met Thr Val Asn Asp Ser Tyr Thr Ala Val Ser 210 215 220 Trp Ser Ala Asp Thr Arg Ala Gly Ser Asn Asp Val Val Lys His Ala 225 230 235 240 His Gly Met Met Asp Thr Ser His Gly Val Gly Asn Val Gly Ser Val 245 250 255 Gly Lys Gly Lys Ser Asp Ala Val Met Asn Asn Ser Arg Trp Cys Arg 260 265 270 Val Ala Ser Met Lys Ser Lys His Lys Val Met Asp Asn Lys Lys Asp 275 280 285 Asp Trp Thr Lys Thr Arg Thr Lys Lys Met Gly Asp Asp Lys Cys Val 290 295 300 His Lys Val Asp Val Arg Val Asn Ser Thr His Met Val Val Val Val 305 310 315 320 Asp Ser Ser Gly Asp His Ala Thr Ala Ala Lys Val Gly Asp Arg Trp 325 330 335 Ala Asn Cys Arg Trp Thr Asp Arg Trp Val Asp Lys Trp His Thr Cys 340 345 350 Ser Thr Trp Ser Lys Asp Ala Met Lys Asn Thr Ser Gly Lys Asp Asn 355 360 365 Met Met Ser Ser His Lys Ser Thr Lys Asp Lys Lys Lys Thr Met Lys 370 375 380 Ser Ser Asn Asp Ser Ala Lys Asn Lys Ser Val Thr Lys Met Trp Met 385 390 395 400 Asn Ala Arg Trp Asp Asn Thr Lys Lys Ser Ser Ala Ser Ala Val Thr 405 410 415 Thr Thr Ser Thr Thr Thr Val Met Thr Val Thr Met Val Thr Thr Arg 420 425 430 Met Val Lys His Ala Lys Lys Arg Thr Val Asp Ser Arg Lys Arg Asp 435 440 445 Val Asp Thr His Ser Trp Thr Arg Ser Ala Val Ser Ser Ala Val Tyr 450 455 460 Arg Lys Gly Asn Ser Asp Lys Val Asn Ala Ala Arg Lys Ala Lys Arg 465 470 475 480 Lys Asp Ala Ser Arg Ser Ala Ala Val Met Ala Asn Gly Val Asn Ala 485 490 495 Ser Arg Ala Ser Asn Ser Arg Trp Thr Cys Ser Arg Val Asn Trp Tyr 500 505 510 Thr Asn Thr Tyr Asn Met Thr Thr Thr Ala Asn Lys Thr Ser Thr Thr 515 520 525 Ser Thr Ala Lys Ser Lys Cys Lys Asp Val Asn Arg Ser Ala Lys Ser 530 535 540 Lys Lys Gly Gly Met Asp Ala Asp Val Ala Thr Asn His Asn His Asp 545 550 555 560 Gly Val Arg Ala Lys Lys Thr Asp Thr Met Arg Tyr Thr Met Ser Ser 565 570 575 Arg Thr Trp Ser Ser Lys Ser Val Tyr Ser Val Thr Tyr Met Arg Gly 580 585 590 Lys Ala Ser Ser Lys Asn Gly Asn Tyr Ser Asp Thr Val Lys Met Ala 595 600 605 Lys Lys Ala Ser Cys Lys Tyr Ser Gly His Trp Lys Lys Ser Ser Val 610 615 620 Ser Cys Lys His Met Asn Lys Arg Lys Asn His Lys Thr Lys Trp Met 625 630 635 640 Ala Val Asp Val Lys Trp Ala Gly Asp Ala Lys Lys Lys Cys Arg Val 645 650 655 Gly Asp Thr Ser Asn Ser Val Asn Gly Gly Lys Lys Ser Ala Ala Ser 660 665 670 Arg Thr Arg Asn Thr Trp Asp His Cys Arg Val Tyr Thr Arg Lys Ala 675 680 685 Lys Ala Gly Asp Lys Thr Val Ser Lys Asp Ser Met His Trp Met Thr 690 695 700 Ala Tyr Arg Asp Tyr Lys Thr Asp Thr Ala Val Met Lys Arg Ala Lys 705 710 715 720 Ala Lys Thr Lys Val Lys Thr Thr Val Asn Ser Val Ala His Ala Ser 725 730 735 Ala Ala Lys Lys Thr Thr Thr Asn Tyr Trp Cys Thr Arg Asn Gly Lys 740 745 750 Cys Lys Thr Val Trp Ala Cys Trp His Ser Tyr Lys Ala Asn Lys Trp 755 760 765 Asn Val Lys Lys Thr Met Asn Val Ala Gly Thr Val Ser Asn Met His 770 775 780 His Ser Asn Asn Arg Ala Thr Thr Asp Gly Gly Val Met Asp Asn Thr 785 790 795 800 Asn Ser Arg Trp Arg His Ala Val Arg Lys Lys Ser Ser Ala Lys Ser 805 810 815 His Ser Asp Lys Ala Ala Tyr Thr Asp Lys Val Asp Ala Ala Met Ala 820 825 830 Lys Ser Asp Thr Ser His Ser Met Lys Lys His Asn Gly Lys Asp Ala 835 840 845 Asn Arg Val Ser Asp Val Ala Lys Lys Asp Val Ser Met Lys Arg Lys 850 855 860 Ala Asn Arg Ser Lys Met Asp Val Lys Met His Ala Thr Lys Ser Val 865 870 875 880 Val Ser Ser His Cys Val Asn Tyr Lys Ser Ser Val Lys Ser Val Met 885 890 895 Val Lys Thr Gly Arg Val Lys Lys Thr Asn Lys Asp Arg Val Thr Ala 900 905 910 Lys His Tyr Asn Gly Ala Lys Val Thr Arg Lys Lys Cys Lys Ser Arg 915 920 925 Lys Met Arg Lys Met Asn Val Thr Trp Ala Ala Thr Asp Thr Thr Lys 930 935 940 Arg Ser Ala Val Gly Met Ser Asn Asp Ser Val Ala Trp Gly Lys Ala 945 950 955 960 Thr Lys Lys Lys Ala His Lys Ser Val Thr Gly Ser Lys Met Val Gly 965 970 975 Lys Lys Thr Val Asp Lys Ser Asn Ser Asn Trp Ala Val Thr Ser Arg 980 985 990 Val Trp Asn Tyr Lys His Met Thr Asp Asn Thr Lys Trp His Ala Asp 995 1000 1005 Asp Ser Lys Lys Lys Lys Asp Lys Arg Lys Ala Met Asn Asp Met 1010 1015 1020 Arg Lys Val Asp Ser Thr Arg Asp Ala Ala Lys Met Ala Asn Arg 1025 1030 1035 Gly Asp His Cys Arg Lys Val Val Ser Asn Arg Arg Ala Ala Ser 1040 1045 1050 His Arg Lys Thr Gly Lys Ala Ser Lys Asn Ser Asp Lys Ala Gly 1055 1060 1065 Val Asn Lys Asp Asn Lys Asp Met Ser Asp Asn Gly Thr Val Asn 1070 1075 1080 Arg Gly Asp Asn Arg Thr Asp Arg Lys Arg Lys Lys Thr Lys His 1085 1090 1095 Asn Ala Lys Asp Arg Ser Arg Arg Lys Lys Ala Ser His Trp Tyr 1100 1105 1110 Tyr Lys Arg Ala Asp Asp Lys Cys Asp Lys Lys Ala Ser Arg Asp 1115 1120 1125 Arg Lys Lys Asp Arg Lys Lys Lys Asn Ala Val Arg Arg Ala Gly 1130 1135 1140 Ser Asn Gly Ala Ala Met Ala Val Thr Ser Lys Arg Trp Arg Ser 1145 1150 1155 Asn Ala Arg Arg Asn Ala His Thr His Thr Met Val Val Thr Thr 1160 1165 1170 Asp Met Asp Val Ser Tyr Val Ser Thr Tyr Thr Ser His Ala Ser 1175 1180 1185 Val Asp His Asn Thr Cys Ala Lys Asp Asp Lys Ser Lys Asn Lys 1190 1195 1200 Asp Asn Ser Gly Arg Asp His Lys Lys Lys Thr Ala Ala Ser Ala 1205 1210 1215 Thr Ser Met Lys Val Lys Val Ala Val Ala Met Asp Gly Lys His 1220 1225 1230 Arg Met Tyr Lys Arg Gly Arg Asp Arg Ser Val Lys Trp Arg His 1235 1240 1245 His Tyr Asp Met Lys Val Asn Trp Asn Val Lys Lys Thr Asn Asn 1250 1255 1260 Trp His Ala Lys Tyr Lys Trp Tyr Lys Asp Gly Gly Arg Ala Val 1265 1270 1275 Val Arg Thr Asn Ala Thr Gly Ser Ser Lys Thr Asp Val Asn Lys 1280 1285 1290 Gly Ser Ser Arg Trp His Asp Cys Lys Ala Arg Arg Lys Arg Lys 1295 1300 1305 Asn Val Ser Arg Asp Asn Val Trp Ala Asp Asn Ala Thr Gly Asp 1310 1315 1320 Lys Val Lys Ala Arg Gly Lys Asn Thr Gly Gly Ala Val Val Ser 1325 1330 1335 Ala Arg Asp Lys Lys Lys Lys Thr Asn Trp Lys Val Ser Arg Ala 1340 1345 1350 Lys Gly Val His Lys Asp Arg Asp His Trp Ser Arg Asn Tyr Asn 1355 1360 1365 Ser Ala Gly Asp Lys Val Thr Val His Gly Lys Ala Asp Val Arg 1370 1375 1380 Ser Lys Gly His Tyr Lys Lys Ser Thr Val Lys Arg Lys Asp Arg 1385 1390 1395 Ser Trp Ala Val Asn His Arg Arg Thr Lys Asp Arg Ala Gly Ser 1400 1405 1410 Thr Thr Gly Ala Ser Ala Ser Thr Val Thr Val Thr Ser Val Val 1415 1420 1425 Thr Lys Thr Val Ser Lys Met Ser Ser Val Ala Ala Asp Asn Arg 1430 1435 1440 Ala Trp Thr Thr Asp Trp Ser Asp Arg Val Lys Ser Arg Val Met 1445 1450 1455 Val Gly Asp Asp Asn Met Lys Lys Ala Thr Asp Arg Arg Thr Ala 1460 1465 1470 Ala Asn Lys Asn Lys Thr Ser Asn Ala Arg Thr Thr Asp Arg Arg 1475 1480 1485 Trp Asp Val Asn Arg Arg Asn Met Lys Asp Ser Thr Trp Ala Lys 1490 1495 1500 Ala Val Gly Val Arg Gly Lys Asp Ser Trp Lys Gly His Thr Val 1505 1510 1515 Asp Ala Lys Lys Thr Thr Lys Ala Lys Asp Arg Arg Ser Val Asp 1520 1525 1530 Val Ala Asn Asp Ala Lys Arg Asp Tyr Ser Ala Asp Asp Thr Arg 1535 1540 1545 Lys Val His Met Thr Asn Asn Thr Ser Trp Gly Asn His Lys Arg 1550 1555 1560 Val Ser Ala Ala Thr His Arg Asp Lys Ser Trp Thr Ala Thr Thr 1565 1570 1575 Ala Asn Val Asp Ala Ser Arg Lys Lys Asp Ser Arg Gly Val Arg 1580 1585 1590 Met Lys Trp Asp Gly Thr His Thr Asp Tyr His Asn Asp Asn Gly 1595 1600 1605 Lys Arg Ser Gly Ser Asp Ala Arg Arg Asp Asn Met Asn Lys Trp 1610 1615 1620 Ser Lys Lys Ser Asn Arg Ser His Ala Ser Ser Asp Trp Lys Arg 1625 1630 1635 His Ser Val Trp Lys Asp Asp Ser Arg Ala Gly Gly Asp Ala Val 1640 1645 1650 Lys Asn Asp His Arg Ala Lys Arg Lys Thr Lys Val Met Ser Thr 1655 1660 1665 Thr Val Arg Thr Gly Lys Tyr Arg Arg Ala Asn Val Thr Arg Arg 1670 1675 1680 Lys Ala Val Asn Ala Trp Asp Lys Asn Arg Ser Ala Asp Trp Arg 1685 1690 1695 Lys Asp Ala Arg Ala Ala Asp Asp Lys Arg Ala Val Lys Gly Ser 1700 1705 1710 Trp Val Gly Asp Asp Ser Asp His Lys Val Lys Ala Arg Gly Ala 1715 1720 1725 Lys Asn Val Asn Arg Val Asn Asp Ala His Thr Thr Gly Ser Tyr 1730 1735 1740 Asn Ser Thr Asp Asn Thr Arg Trp Arg Val Ala Val Asp Arg Val 1745 1750 1755 Arg His Ala His Arg Asp Gly Ala Ser His Ser Thr Ser Val Gly 1760 1765 1770 Trp Arg Ala Ser Asn Lys Val Tyr Tyr Asn His Thr Thr Thr Cys 1775 1780 1785 Trp Asp His Lys Met Thr Tyr Ser Ala Asp Asn Asn Val Arg Ser 1790 1795 1800 Ala Tyr Arg Thr Ala Met Lys Arg Arg Lys Ala Cys Asp Ser Ser 1805 1810 1815 Ala Ala Cys Asp Ala Asp His Asn Lys Asn Asp Met Asp Asn Cys 1820 1825 1830 Thr Thr Tyr Asp Arg His Asn Asn Val Asn Val Cys Val Asp Met 1835 1840 1845 Cys Asn Trp Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Arg Val 1850 1855 1860 Ser Lys Thr Gly Ser Cys Lys Ala His Asp Lys Tyr Arg Tyr Lys 1865 1870 1875 Val Ala Ser Ser Thr Gly Cys Asp Arg Arg Gly His Asp Ser Arg 1880 1885 1890 Gly Val Ala Ser Gly Gly Ser Asn Ser Val Arg Ser Cys Ala Asn 1895 1900 1905 Asn Lys Ala Ala Asp Trp Met Arg Ser Met Val Trp Val His Arg 1910 1915 1920 Val Ala Ala Ala Thr Ala Lys His Ala Lys Cys Asn Cys Lys Cys 1925 1930 1935 Gly Arg Tyr Arg Ser Lys His Asn Tyr Asp Cys Ser Cys Ser Gly 1940 1945 1950 Arg Val Ala Lys Gly His Lys Met His Tyr Met Val Tyr Cys Thr 1955 1960 1965 Thr Thr Ser Gly Asp Val Arg Asp Ala Lys Val Lys Asn Lys Arg 1970 1975 1980 Thr Lys Arg Tyr Ala Lys His Arg Met Gly Tyr Val Thr Val Gly 1985 1990 1995 Asp Asn Met Thr Val Thr Asn Trp Val Asp Ser Ala Ala Ser Ser 2000 2005 2010 Ser His Asp Asp Thr His Ser Arg His Tyr Ala Ser Arg Ala Met 2015 2020 2025 Asn Ser Asn Gly Ser Tyr Asn Asp Ser Ser Asn Ser Asp Asp His 2030 2035 2040 His Tyr Cys Ser Asn Asp Ser Ser Arg Ser Ala Ser Ser Arg Gly 2045 2050 2055 Arg Ala Asp Asn Arg Asn Ala Tyr Asp Arg Lys His His Lys Gly 2060 2065 2070 Ser Ser Met Met Thr Ser Ser Arg Asp Ala Ala Ala Lys Arg His 2075 2080 2085 Lys Gly Arg Ala Arg Met Asp His Asn Lys Ser His Arg Arg Ala 2090 2095 2100 Ala Lys Val Asn Gly Thr Thr Val Ser Ser Ser Thr Ser Arg Ser 2105 2110 2115 Asp Ser Ser Met Arg Val Val Gly Ser Thr Ser Ser Met Gly Asp 2120 2125 2130 Ser Asp Thr Ser Thr Gly Val Met Asn Asn Ser Ser Ser Arg Gly 2135 2140 2145 Arg Asn Ala Gly Lys Met Arg Asp Thr Met 2150 2155 <210> 870 <211> 1307 <212> PRT <213> Acidaminococcus sp. BV3L6 <400> 870 Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 1 5 10 15 Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 20 25 30 Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 35 40 45 Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 50 55 60 Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 65 70 75 80 Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 85 90 95 Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 100 105 110 Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 115 120 125 Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 130 135 140 Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 145 150 155 160 Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 165 170 175 Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 180 185 190 Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 195 200 205 Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 210 215 220 Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 225 230 235 240 Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 245 250 255 Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 260 265 270 Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 275 280 285 Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 290 295 300 Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 305 310 315 320 Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 325 330 335 Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 340 345 350 Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 355 360 365 Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 370 375 380 Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 385 390 395 400 Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 405 410 415 Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 420 425 430 Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 435 440 445 Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 450 455 460 Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 465 470 475 480 Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 485 490 495 Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 500 505 510 Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 515 520 525 Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 530 535 540 Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 545 550 555 560 Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 565 570 575 Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 580 585 590 Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 595 600 605 Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 610 615 620 Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 625 630 635 640 Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 645 650 655 Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 660 665 670 Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 675 680 685 Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 690 695 700 Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 705 710 715 720 Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 725 730 735 Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 740 745 750 Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 755 760 765 Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 770 775 780 Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 785 790 795 800 Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 805 810 815 Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 820 825 830 Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 835 840 845 Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 850 855 860 Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 865 870 875 880 Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 885 890 895 Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 900 905 910 Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 915 920 925 Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 930 935 940 Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 945 950 955 960 Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 965 970 975 His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 980 985 990 Glu Asn Leu Asn Phe Gly Phe Lys Ser Lys Arg Thr Gly Ile Ala Glu 995 1000 1005 Lys Ala Val Tyr Gln Gln Phe Glu Lys Met Leu Ile Asp Lys Leu 1010 1015 1020 Asn Cys Leu Val Leu Lys Asp Tyr Pro Ala Glu Lys Val Gly Gly 1025 1030 1035 Val Leu Asn Pro Tyr Gln Leu Thr Asp Gln Phe Thr Ser Phe Ala 1040 1045 1050 Lys Met Gly Thr Gln Ser Gly Phe Leu Phe Tyr Val Pro Ala Pro 1055 1060 1065 Tyr Thr Ser Lys Ile Asp Pro Leu Thr Gly Phe Val Asp Pro Phe 1070 1075 1080 Val Trp Lys Thr Ile Lys Asn His Glu Ser Arg Lys His Phe Leu 1085 1090 1095 Glu Gly Phe Asp Phe Leu His Tyr Asp Val Lys Thr Gly Asp Phe 1100 1105 1110 Ile Leu His Phe Lys Met Asn Arg Asn Leu Ser Phe Gln Arg Gly 1115 1120 1125 Leu Pro Gly Phe Met Pro Ala Trp Asp Ile Val Phe Glu Lys Asn 1130 1135 1140 Glu Thr Gln Phe Asp Ala Lys Gly Thr Pro Phe Ile Ala Gly Lys 1145 1150 1155 Arg Ile Val Pro Val Ile Glu Asn His Arg Phe Thr Gly Arg Tyr 1160 1165 1170 Arg Asp Leu Tyr Pro Ala Asn Glu Leu Ile Ala Leu Leu Glu Glu 1175 1180 1185 Lys Gly Ile Val Phe Arg Asp Gly Ser Asn Ile Leu Pro Lys Leu 1190 1195 1200 Leu Glu Asn Asp Asp Ser His Ala Ile Asp Thr Met Val Ala Leu 1205 1210 1215 Ile Arg Ser Val Leu Gln Met Arg Asn Ser Asn Ala Ala Thr Gly 1220 1225 1230 Glu Asp Tyr Ile Asn Ser Pro Val Arg Asp Leu Asn Gly Val Cys 1235 1240 1245 Phe Asp Ser Arg Phe Gln Asn Pro Glu Trp Pro Met Asp Ala Asp 1250 1255 1260 Ala Asn Gly Ala Tyr His Ile Ala Leu Lys Gly Gln Leu Leu Leu 1265 1270 1275 Asn His Leu Lys Glu Ser Lys Asp Leu Lys Leu Gln Asn Gly Ile 1280 1285 1290 Ser Asn Gln Asp Trp Leu Ala Tyr Ile Gln Glu Leu Arg Asn 1295 1300 1305 <210> 871 <211> 1228 <212> PRT <213> Lachnospiraceae bacterium ND2006 <400> 871 Ala Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 1 5 10 15 Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 20 25 30 Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 35 40 45 Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 50 55 60 Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 65 70 75 80 Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 85 90 95 Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 100 105 110 Ala Ala Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 115 120 125 Leu Pro Glu Ala Ala Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 130 135 140 Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 145 150 155 160 Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 165 170 175 Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 180 185 190 Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 195 200 205 Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 210 215 220 Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 225 230 235 240 Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 245 250 255 Asn Glu Tyr Ile Asn Leu Tyr Asn Ala Lys Thr Lys Gln Ala Leu Pro 260 265 270 Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 275 280 285 Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 290 295 300 Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 305 310 315 320 Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 325 330 335 Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 340 345 350 Phe Gly Glu Trp Asn Leu Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 355 360 365 Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 370 375 380 Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 385 390 395 400 Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 405 410 415 Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 420 425 430 Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 435 440 445 Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 450 455 460 Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 465 470 475 480 Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 485 490 495 Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 500 505 510 Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 515 520 525 Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 530 535 540 Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 545 550 555 560 Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 565 570 575 Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 580 585 590 Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 595 600 605 Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 610 615 620 Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 625 630 635 640 Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 645 650 655 Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 660 665 670 Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 675 680 685 Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 690 695 700 Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 705 710 715 720 His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 725 730 735 Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 740 745 750 Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 755 760 765 Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 770 775 780 Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 785 790 795 800 Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 805 810 815 Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 820 825 830 Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 835 840 845 Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 850 855 860 Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 865 870 875 880 Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 885 890 895 Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 900 905 910 Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 915 920 925 Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 930 935 940 Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 945 950 955 960 Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 965 970 975 Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 980 985 990 Phe Ile Phe Tyr Ile Pro Ala Trp Leu Thr Ser Lys Ile Asp Pro Ser 995 1000 1005 Thr Gly Phe Val Asn Leu Leu Lys Thr Lys Tyr Thr Ser Ile Ala 1010 1015 1020 Asp Ser Lys Lys Phe Ile Ser Ser Phe Asp Arg Ile Met Tyr Val 1025 1030 1035 Pro Glu Glu Asp Leu Phe Glu Phe Ala Leu Asp Tyr Lys Asn Phe 1040 1045 1050 Ser Arg Thr Asp Ala Asp Tyr Ile Lys Lys Trp Lys Leu Tyr Ser 1055 1060 1065 Tyr Gly Asn Arg Ile Arg Ile Phe Ala Ala Ala Lys Lys Asn Asn 1070 1075 1080 Val Phe Ala Trp Glu Glu Val Cys Leu Thr Ser Ala Tyr Lys Glu 1085 1090 1095 Leu Phe Asn Lys Tyr Gly Ile Asn Tyr Gln Gln Gly Asp Ile Arg 1100 1105 1110 Ala Leu Leu Cys Glu Gln Ser Asp Lys Ala Phe Tyr Ser Ser Phe 1115 1120 1125 Met Ala Leu Met Ser Leu Met Leu Gln Met Arg Asn Ser Ile Thr 1130 1135 1140 Gly Arg Thr Asp Val Asp Phe Leu Ile Ser Pro Val Lys Asn Ser 1145 1150 1155 Asp Gly Ile Phe Tyr Asp Ser Arg Asn Tyr Glu Ala Gln Glu Asn 1160 1165 1170 Ala Ile Leu Pro Lys Asn Ala Asp Ala Asn Gly Ala Tyr Asn Ile 1175 1180 1185 Ala Arg Lys Val Leu Trp Ala Ile Gly Gln Phe Lys Lys Ala Glu 1190 1195 1200 Asp Glu Lys Leu Asp Lys Val Lys Ile Ala Ile Ser Asn Lys Glu 1205 1210 1215 Trp Leu Glu Tyr Ala Gln Thr Ser Val Lys 1220 1225 <210> 872 <211> 4101 <212> DNA <213> Streptococcus pyogenes <400> 872 gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc 60 accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac 120 agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc 180 acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat 240 ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg 300 gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac 360 atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa 420 ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg 480 atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg 540 gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc 600 aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg 660 ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggcaacctg 720 attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat 780 gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag 840 atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg 900 ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg 960 atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag 1020 cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc 1080 tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa 1140 aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag 1200 cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc 1260 attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag 1320 aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga 1380 ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg 1440 gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac 1500 ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat 1560 aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc 1620 ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg 1680 aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc 1740 ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc 1800 aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg 1860 accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac 1920 ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg 1980 ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat 2040 ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc 2100 ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac 2160 gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg 2220 aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc 2280 gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg 2340 aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg 2400 gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat 2460 atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc 2520 gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac 2580 aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac 2640 tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc 2700 aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg 2760 gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact 2820 aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag 2880 ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac 2940 caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac 3000 cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg 3060 atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac 3120 atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct 3180 ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc 3240 accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag 3300 acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc 3360 agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat 3420 tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa 3480 gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt 3540 ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac 3600 tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag 3660 aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac 3720 tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag 3780 cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc 3840 ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc 3900 atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct 3960 gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag 4020 gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac 4080 ctgtctcagc tgggaggcga c 4101 <210> 873 <211> 1053 <212> PRT <213> Staphylococcus aureus <400> 873 Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 1 5 10 15 Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 20 25 30 Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 35 40 45 Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 50 55 60 Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 65 70 75 80 Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 85 90 95 Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 100 105 110 Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 115 120 125 Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 130 135 140 Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 145 150 155 160 Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 165 170 175 Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 180 185 190 Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 195 200 205 Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 210 215 220 Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 225 230 235 240 Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 245 250 255 Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 260 265 270 Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 275 280 285 Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 290 295 300 Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 305 310 315 320 Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 325 330 335 Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 340 345 350 Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 355 360 365 Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 370 375 380 Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 385 390 395 400 Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 405 410 415 Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 420 425 430 Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 435 440 445 Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 450 455 460 Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 465 470 475 480 Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 485 490 495 Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 500 505 510 Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 515 520 525 Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 530 535 540 Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 545 550 555 560 Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 565 570 575 Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 580 585 590 Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 595 600 605 Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 610 615 620 Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 625 630 635 640 Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 645 650 655 Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 660 665 670 Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 675 680 685 Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 690 695 700 Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 705 710 715 720 Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 725 730 735 Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 740 745 750 Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 755 760 765 Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 770 775 780 Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 785 790 795 800 Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 805 810 815 Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 820 825 830 Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 835 840 845 Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 850 855 860 Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 865 870 875 880 Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 885 890 895 Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 900 905 910 Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 915 920 925 Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 930 935 940 Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 945 950 955 960 Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 965 970 975 Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 980 985 990 Glu Val Asn Met Ile Asp Ile Thr Tyr Arg Glu Tyr Leu Glu Asn Met 995 1000 1005 Asn Asp Lys Arg Pro Pro Arg Ile Ile Lys Thr Ile Ala Ser Lys 1010 1015 1020 Thr Gln Ser Ile Lys Lys Tyr Ser Thr Asp Ile Leu Gly Asn Leu 1025 1030 1035 Tyr Glu Val Lys Ser Lys Lys His Pro Gln Ile Ile Lys Lys Gly 1040 1045 1050 <210> 874 <211> 450 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 874 ctagactagc atgctgccca tgtaaggagg caaggcctgg ggacacccga gatgcctggt 60 tataattaac ccagacatgt ggctgccccc ccccccccaa cacctgctgc ctctaaaaat 120 aaccctgcat gccatgttcc cggcgaaggg ccagctgtcc cccgccagct agactcagca 180 cttagtttag gaaccagtga gcaagtcagc ccttggggca gcccatacaa ggccatgggg 240 ctgggcaagc tgcacgcctg ggtccggggt gggcacggtg cccgggcaac gagctgaaag 300 ctcatctgct ctcaggggcc cctccctggg gacagcccct cctggctagt cacaccctgt 360 aggctcctct atataaccca ggggcacagg ggctgccctc attctaccac cacctccaca 420 gcacagacag acactcagga gccagccagc 450 <210> 875 <211> 436 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 875 tgcccatgta aggaggcaag gcctggggac acccgagatg cctggttata attaacccag 60 acatgtggct gccccccccc ccccaacacc tgctgcctct aaaaataacc ctgcatgcca 120 tgttcccggc gaagggccag ctgtcccccg ccagctagac tcagcactta gtttaggaac 180 cagtgagcaa gtcagccctt ggggcagccc atacaaggcc atggggctgg gcaagctgca 240 cgcctgggtc cggggtgggc acggtgcccg ggcaacgagc tgaaagctca tctgctctca 300 ggggcccctc cctggggaca gcccctcctg gctagtcaca ccctgtaggc tcctctatat 360 aacccagggg cacaggggct gccctcattc taccaccacc tccacagcac agacagacac 420 tcaggagcca gccagc 436 <210> 876 <400> 876 000 <210> 877 <400> 877 000 <210> 878 <400> 878 000 <210> 879 <400> 879 000 <210> 880 <211> 115 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 880 ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg 60 acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag aggga 115 <210> 881 <211> 141 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 881 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc t 141 <210> 882 <211> 141 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 882 aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg 60 ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc 120 gagcgcgcag ctgcctgcag g 141 <210> 883 <211> 141 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 883 ccactccctc tatgcgcgct cgctcactca ctcggccctg gagaccaaag gtctccagac 60 tgccggcctc tggccggcag ggccgagtga gtgagcgagc gcgcatagag ggagtgggta 120 cctccatcat ctaggtttgc c 141 <210> 884 <211> 9 <212> PRT <213> Unknown <220> <221> source <223> /note="Description of Unknown: c-myc NLS sequence" <400> 884 Pro Ala Ala Lys Arg Val Lys Leu Asp 1 5 <210> 885 <211> 51 <212> DNA <213> Simian virus 40 <400> 885 atggccccaa agaagaagcg gaaggtcggt atccacggag tcccagcagc c 51 <210> 886 <211> 42 <212> PRT <213> Homo sapiens <400> 886 Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly 1 5 10 15 Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr 20 25 30 Phe Ala Lys Pro Arg Asn Gln Gly Gly Tyr 35 40 <210> 887 <211> 48 <212> DNA <213> Unknown <220> <221> source <223> /note="Description of Unknown: Nucleoplasmin NLS sequence" <400> 887 aagcgtcctg ctgctactaa gaaagctggt caagctaaga aaaagaaa 48 <210> 888 <211> 41 <212> PRT <213> Unknown <220> <221> source <223> /note="Description of Unknown: IBB domain from importin-alpha sequence" <400> 888 Arg Met Arg Lys Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu Arg 1 5 10 15 Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys Asp 20 25 30 Glu Gln Ile Leu Lys Arg Arg Asn Val 35 40 <210> 889 <211> 8 <212> PRT <213> Unknown <220> <221> source <223> /note="Description of Unknown: Myoma T protein sequence" <400> 889 Val Ser Arg Lys Arg Pro Arg Pro 1 5 <210> 890 <211> 8 <212> PRT <213> Unknown <220> <221> source <223> /note="Description of Unknown: Myoma T protein sequence" <400> 890 Pro Pro Lys Lys Ala Arg Glu Asp 1 5 <210> 891 <211> 8 <212> PRT <213> Homo sapiens <400> 891 Pro Gln Pro Lys Lys Lys Pro Leu 1 5 <210> 892 <211> 12 <212> PRT <213> Mus musculus <400> 892 Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 1 5 10 <210> 893 <211> 5 <212> PRT <213> Influenza virus <400> 893 Asp Arg Leu Arg Arg 1 5 <210> 894 <211> 6 <212> PRT <213> Influenza virus <400> 894 Lys Gln Lys Lys Arg Lys 1 5 <210> 895 <211> 10 <212> PRT <213> Hepatitis delta virus <400> 895 Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 1 5 10 <210> 896 <211> 10 <212> PRT <213> Mus musculus <400> 896 Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 1 5 10 <210> 897 <211> 20 <212> PRT <213> Homo sapiens <400> 897 Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 1 5 10 15 Lys Ser Lys Lys 20 <210> 898 <211> 17 <212> PRT <213> Homo sapiens <400> 898 Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 1 5 10 15 Lys <210> 899 <211> 5133 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 899 ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg 60 acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggagtggc 120 caactccatc actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac 180 gtagccatgc tctagattaa ttaatgccca tgtaaggagg caaggcctgg ggacacccga 240 gatgcctggt tataattaac ccagacatgt ggctgccccc ccccccccaa cacctgctgc 300 ctctaaaaat aaccctgcat gccatgttcc cggcgaaggg ccagctgtcc cccgccagct 360 agactcagca cttagtttag gaaccagtga gcaagtcagc ccttggggca gcccatacaa 420 ggccatgggg ctgggcaagc tgcacgcctg ggtccggggt gggcacggtg cccgggcaac 480 gagctgaaag ctcatctgct ctcaggggcc cctccctggg gacagcccct cctggctagt 540 cacaccctgt aggctcctct atataaccca ggggcacagg ggctgccctc attctaccac 600 cacctccaca gcacagacag acactcagga gccagccagc gctagcgcca ccatgatggc 660 cccaaagaag aagcggaagg tcggtatcca cggagtccca gcagccgaca agaagtacag 720 catcggcctg gacatcggca ccaactctgt gggctgggcc gtgatcaccg acgagtacaa 780 ggtgcccagc aagaaattca aggtgctggg caacaccgac cggcacagca tcaagaagaa 840 cctgatcgga gccctgctgt tcgacagcgg cgaaacagcc gaggccaccc ggctgaagag 900 aaccgccaga agaagataca ccagacggaa gaaccggatc tgctatctgc aagagatctt 960 cagcaacgag atggccaagg tggacgacag cttcttccac agactggaag agtccttcct 1020 ggtggaagag gataagaagc acgagcggca ccccatcttc ggcaacatcg tggacgaggt 1080 ggcctaccac gagaagtacc ccaccatcta ccacctgaga aagaaactgg tggacagcac 1140 cgacaaggcc gacctgcggc tgatctatct ggccctggcc cacatgatca agttccgggg 1200 ccacttcctg atcgagggcg acctgaaccc cgacaacagc gacgtggaca agctgttcat 1260 ccagctggtg cagacctaca accagctgtt cgaggaaaac cccatcaacg ccagcggcgt 1320 ggacgccaag gccatcctgt ctgccagact gagcaagagc agacggctgg aaaatctgat 1380 cgcccagctg cccggcgaga agaagaatgg cctgttcggc aacctgattg ccctgagcct 1440 gggcctgacc cccaacttca agagcaactt cgacctggcc gaggatgcca aactgcagct 1500 gagcaaggac acctacgacg acgacctgga caacctgctg gcccagatcg gcgaccagta 1560 cgccgacctg tttctggccg ccaagaacct gtccgacgcc atcctgctga gcgacatcct 1620 gagagtgaac accgagatca ccaaggcccc cctgagcgcc tctatgatca agagatacga 1680 cgagcaccac caggacctga ccctgctgaa agctctcgtg cggcagcagc tgcctgagaa 1740 gtacaaagag attttcttcg accagagcaa gaacggctac gccggctaca ttgacggcgg 1800 agccagccag gaagagttct acaagttcat caagcccatc ctggaaaaga tggacggcac 1860 cgaggaactg ctcgtgaagc tgaacagaga ggacctgctg cggaagcagc ggaccttcga 1920 caacggcagc atcccccacc agatccacct gggagagctg cacgccattc tgcggcggca 1980 ggaagatttt tacccattcc tgaaggacaa ccgggaaaag atcgagaaga tcctgacctt 2040 ccgcatcccc tactacgtgg gccctctggc caggggaaac agcagattcg cctggatgac 2100 cagaaagagc gaggaaacca tcaccccctg gaacttcgag gaagtggtgg acaagggcgc 2160 ttccgcccag agcttcatcg agcggatgac caacttcgat aagaacctgc ccaacgagaa 2220 ggtgctgccc aagcacagcc tgctgtacga gtacttcacc gtgtataacg agctgaccaa 2280 agtgaaatac gtgaccgagg gaatgagaaa gcccgccttc ctgagcggcg agcagaaaaa 2340 ggccatcgtg gacctgctgt tcaagaccaa ccggaaagtg accgtgaagc agctgaaaga 2400 ggactacttc aagaaaatcg agtgcttcga ctccgtggaa atctccggcg tggaagatcg 2460 gttcaacgcc tccctgggca cataccacga tctgctgaaa attatcaagg acaaggactt 2520 cctggacaat gaggaaaacg aggacattct ggaagatatc gtgctgaccc tgacactgtt 2580 tgaggacaga gagatgatcg aggaacggct gaaaacctat gcccacctgt tcgacgacaa 2640 agtgatgaag cagctgaagc ggcggagata caccggctgg ggcaggctga gccggaagct 2700 gatcaacggc atccgggaca agcagtccgg caagacaatc ctggatttcc tgaagtccga 2760 cggcttcgcc aacagaaact tcatgcagct gatccacgac gacagcctga cctttaaaga 2820 ggacatccag aaagcccagg tgtccggcca gggcgatagc ctgcacgagc acattgccaa 2880 tctggccggc agccccgcca ttaagaaggg catcctgcag acagtgaagg tggtggacga 2940 gctcgtgaaa gtgatgggcc ggcacaagcc cgagaacatc gtgatcgaaa tggccagaga 3000 gaaccagacc acccagaagg gacagaagaa cagccgcgag agaatgaagc ggatcgaaga 3060 gggcatcaaa gagctgggca gccagatcct gaaagaacac cccgtggaaa acacccagct 3120 gcagaacgag aagctgtacc tgtactacct gcagaatggg cgggatatgt acgtggacca 3180 ggaactggac atcaaccggc tgtccgacta cgatgtggac catatcgtgc ctcagagctt 3240 tctgaaggac gactccatcg acaacaaggt gctgaccaga agcgacaaga accggggcaa 3300 gagcgacaac gtgccctccg aagaggtcgt gaagaagatg aagaactact ggcggcagct 3360 gctgaacgcc aagctgatta cccagagaaa gttcgacaat ctgaccaagg ccgagagagg 3420 cggcctgagc gaactggata aggccggctt catcaagaga cagctggtgg aaacccggca 3480 gatcacaaag cacgtggcac agatcctgga ctcccggatg aacactaagt acgacgagaa 3540 tgacaagctg atccgggaag tgaaagtgat caccctgaag tccaagctgg tgtccgattt 3600 ccggaaggat ttccagtttt acaaagtgcg cgagatcaac aactaccacc acgcccacga 3660 cgcctacctg aacgccgtcg tgggaaccgc cctgatcaaa aagtacccta agctggaaag 3720 cgagttcgtg tacggcgact acaaggtgta cgacgtgcgg aagatgatcg ccaagagcga 3780 gcaggaaatc ggcaaggcta ccgccaagta cttcttctac agcaacatca tgaacttttt 3840 caagaccgag attaccctgg ccaacggcga gatccggaag cggcctctga tcgagacaaa 3900 cggcgaaacc ggggagatcg tgtgggataa gggccgggat tttgccaccg tgcggaaagt 3960 gctgagcatg ccccaagtga atatcgtgaa aaagaccgag gtgcagacag gcggcttcag 4020 caaagagtct atcctgccca agaggaacag cgataagctg atcgccagaa agaaggactg 4080 ggaccctaag aagtacggcg gcttcgacag ccccaccgtg gcctattctg tgctggtggt 4140 ggccaaagtg gaaaagggca agtccaagaa actgaagagt gtgaaagagc tgctggggat 4200 caccatcatg gaaagaagca gcttcgagaa gaatcccatc gactttctgg aagccaaggg 4260 ctacaaagaa gtgaaaaagg acctgatcat caagctgcct aagtactccc tgttcgagct 4320 ggaaaacggc cggaagagaa tgctggcctc tgccggcgaa ctgcagaagg gaaacgaact 4380 ggccctgccc tccaaatatg tgaacttcct gtacctggcc agccactatg agaagctgaa 4440 gggctccccc gaggataatg agcagaaaca gctgtttgtg gaacagcaca agcactacct 4500 ggacgagatc atcgagcaga tcagcgagtt ctccaagaga gtgatcctgg ccgacgctaa 4560 tctggacaaa gtgctgtccg cctacaacaa gcaccgggat aagcccatca gagagcaggc 4620 cgagaatatc atccacctgt ttaccctgac caatctggga gcccctgccg ccttcaagta 4680 ctttgacacc accatcgacc ggaagaggta caccagcacc aaagaggtgc tggacgccac 4740 cctgatccac cagagcatca ccggcctgta cgagacacgg atcgacctgt ctcagctggg 4800 aggcgacaag cgtcctgctg ctactaagaa agctggtcaa gctaagaaaa agaaatgaat 4860 cgattagcaa taaaggatcg tttattttca ttggaagcgt gtgttggttt tttgatcagg 4920 cgcgggtacc aggtcgcggc cgctctagag catggctacg tagataagta gcatggcggg 4980 ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct 5040 cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg 5100 gcctcagtga gcgagcgagc gcgcagagag gga 5133 <210> 900 <211> 5185 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 900 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc tgtggccaac tccatcacta ggggttcctt gtagttaatg 180 attaacccgc catgctactt atctacgtag ccatgctcta gattaattaa tgcccatgta 240 aggaggcaag gcctggggac acccgagatg cctggttata attaacccag acatgtggct 300 gccccccccc ccccaacacc tgctgcctct aaaaataacc ctgcatgcca tgttcccggc 360 gaagggccag ctgtcccccg ccagctagac tcagcactta gtttaggaac cagtgagcaa 420 gtcagccctt ggggcagccc atacaaggcc atggggctgg gcaagctgca cgcctgggtc 480 cggggtgggc acggtgcccg ggcaacgagc tgaaagctca tctgctctca ggggcccctc 540 cctggggaca gcccctcctg gctagtcaca ccctgtaggc tcctctatat aacccagggg 600 cacaggggct gccctcattc taccaccacc tccacagcac agacagacac tcaggagcca 660 gccagcgcta gcgccaccat gatggcccca aagaagaagc ggaaggtcgg tatccacgga 720 gtcccagcag ccgacaagaa gtacagcatc ggcctggaca tcggcaccaa ctctgtgggc 780 tgggccgtga tcaccgacga gtacaaggtg cccagcaaga aattcaaggt gctgggcaac 840 accgaccggc acagcatcaa gaagaacctg atcggagccc tgctgttcga cagcggcgaa 900 acagccgagg ccacccggct gaagagaacc gccagaagaa gatacaccag acggaagaac 960 cggatctgct atctgcaaga gatcttcagc aacgagatgg ccaaggtgga cgacagcttc 1020 ttccacagac tggaagagtc cttcctggtg gaagaggata agaagcacga gcggcacccc 1080 atcttcggca acatcgtgga cgaggtggcc taccacgaga agtaccccac catctaccac 1140 ctgagaaaga aactggtgga cagcaccgac aaggccgacc tgcggctgat ctatctggcc 1200 ctggcccaca tgatcaagtt ccggggccac ttcctgatcg agggcgacct gaaccccgac 1260 aacagcgacg tggacaagct gttcatccag ctggtgcaga cctacaacca gctgttcgag 1320 gaaaacccca tcaacgccag cggcgtggac gccaaggcca tcctgtctgc cagactgagc 1380 aagagcagac ggctggaaaa tctgatcgcc cagctgcccg gcgagaagaa gaatggcctg 1440 ttcggcaacc tgattgccct gagcctgggc ctgaccccca acttcaagag caacttcgac 1500 ctggccgagg atgccaaact gcagctgagc aaggacacct acgacgacga cctggacaac 1560 ctgctggccc agatcggcga ccagtacgcc gacctgtttc tggccgccaa gaacctgtcc 1620 gacgccatcc tgctgagcga catcctgaga gtgaacaccg agatcaccaa ggcccccctg 1680 agcgcctcta tgatcaagag atacgacgag caccaccagg acctgaccct gctgaaagct 1740 ctcgtgcggc agcagctgcc tgagaagtac aaagagattt tcttcgacca gagcaagaac 1800 ggctacgccg gctacattga cggcggagcc agccaggaag agttctacaa gttcatcaag 1860 cccatcctgg aaaagatgga cggcaccgag gaactgctcg tgaagctgaa cagagaggac 1920 ctgctgcgga agcagcggac cttcgacaac ggcagcatcc cccaccagat ccacctggga 1980 gagctgcacg ccattctgcg gcggcaggaa gatttttacc cattcctgaa ggacaaccgg 2040 gaaaagatcg agaagatcct gaccttccgc atcccctact acgtgggccc tctggccagg 2100 ggaaacagca gattcgcctg gatgaccaga aagagcgagg aaaccatcac cccctggaac 2160 ttcgaggaag tggtggacaa gggcgcttcc gcccagagct tcatcgagcg gatgaccaac 2220 ttcgataaga acctgcccaa cgagaaggtg ctgcccaagc acagcctgct gtacgagtac 2280 ttcaccgtgt ataacgagct gaccaaagtg aaatacgtga ccgagggaat gagaaagccc 2340 gccttcctga gcggcgagca gaaaaaggcc atcgtggacc tgctgttcaa gaccaaccgg 2400 aaagtgaccg tgaagcagct gaaagaggac tacttcaaga aaatcgagtg cttcgactcc 2460 gtggaaatct ccggcgtgga agatcggttc aacgcctccc tgggcacata ccacgatctg 2520 ctgaaaatta tcaaggacaa ggacttcctg gacaatgagg aaaacgagga cattctggaa 2580 gatatcgtgc tgaccctgac actgtttgag gacagagaga tgatcgagga acggctgaaa 2640 acctatgccc acctgttcga cgacaaagtg atgaagcagc tgaagcggcg gagatacacc 2700 ggctggggca ggctgagccg gaagctgatc aacggcatcc gggacaagca gtccggcaag 2760 acaatcctgg atttcctgaa gtccgacggc ttcgccaaca gaaacttcat gcagctgatc 2820 cacgacgaca gcctgacctt taaagaggac atccagaaag cccaggtgtc cggccagggc 2880 gatagcctgc acgagcacat tgccaatctg gccggcagcc ccgccattaa gaagggcatc 2940 ctgcagacag tgaaggtggt ggacgagctc gtgaaagtga tgggccggca caagcccgag 3000 aacatcgtga tcgaaatggc cagagagaac cagaccaccc agaagggaca gaagaacagc 3060 cgcgagagaa tgaagcggat cgaagagggc atcaaagagc tgggcagcca gatcctgaaa 3120 gaacaccccg tggaaaacac ccagctgcag aacgagaagc tgtacctgta ctacctgcag 3180 aatgggcggg atatgtacgt ggaccaggaa ctggacatca accggctgtc cgactacgat 3240 gtggaccata tcgtgcctca gagctttctg aaggacgact ccatcgacaa caaggtgctg 3300 accagaagcg acaagaaccg gggcaagagc gacaacgtgc cctccgaaga ggtcgtgaag 3360 aagatgaaga actactggcg gcagctgctg aacgccaagc tgattaccca gagaaagttc 3420 gacaatctga ccaaggccga gagaggcggc ctgagcgaac tggataaggc cggcttcatc 3480 aagagacagc tggtggaaac ccggcagatc acaaagcacg tggcacagat cctggactcc 3540 cggatgaaca ctaagtacga cgagaatgac aagctgatcc gggaagtgaa agtgatcacc 3600 ctgaagtcca agctggtgtc cgatttccgg aaggatttcc agttttacaa agtgcgcgag 3660 atcaacaact accaccacgc ccacgacgcc tacctgaacg ccgtcgtggg aaccgccctg 3720 atcaaaaagt accctaagct ggaaagcgag ttcgtgtacg gcgactacaa ggtgtacgac 3780 gtgcggaaga tgatcgccaa gagcgagcag gaaatcggca aggctaccgc caagtacttc 3840 ttctacagca acatcatgaa ctttttcaag accgagatta ccctggccaa cggcgagatc 3900 cggaagcggc ctctgatcga gacaaacggc gaaaccgggg agatcgtgtg ggataagggc 3960 cgggattttg ccaccgtgcg gaaagtgctg agcatgcccc aagtgaatat cgtgaaaaag 4020 accgaggtgc agacaggcgg cttcagcaaa gagtctatcc tgcccaagag gaacagcgat 4080 aagctgatcg ccagaaagaa ggactgggac cctaagaagt acggcggctt cgacagcccc 4140 accgtggcct attctgtgct ggtggtggcc aaagtggaaa agggcaagtc caagaaactg 4200 aagagtgtga aagagctgct ggggatcacc atcatggaaa gaagcagctt cgagaagaat 4260 cccatcgact ttctggaagc caagggctac aaagaagtga aaaaggacct gatcatcaag 4320 ctgcctaagt actccctgtt cgagctggaa aacggccgga agagaatgct ggcctctgcc 4380 ggcgaactgc agaagggaaa cgaactggcc ctgccctcca aatatgtgaa cttcctgtac 4440 ctggccagcc actatgagaa gctgaagggc tcccccgagg ataatgagca gaaacagctg 4500 tttgtggaac agcacaagca ctacctggac gagatcatcg agcagatcag cgagttctcc 4560 aagagagtga tcctggccga cgctaatctg gacaaagtgc tgtccgccta caacaagcac 4620 cgggataagc ccatcagaga gcaggccgag aatatcatcc acctgtttac cctgaccaat 4680 ctgggagccc ctgccgcctt caagtacttt gacaccacca tcgaccggaa gaggtacacc 4740 agcaccaaag aggtgctgga cgccaccctg atccaccaga gcatcaccgg cctgtacgag 4800 acacggatcg acctgtctca gctgggaggc gacaagcgtc ctgctgctac taagaaagct 4860 ggtcaagcta agaaaaagaa atgaatcgat tagcaataaa ggatcgttta ttttcattgg 4920 aagcgtgtgt tggttttttg atcaggcgcg ggtaccaggt cgcggccgct ctagagcatg 4980 gctacgtaga taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg 5040 agttaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact 5100 gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc 5160 gagcgagcgc gcagctgcct gcagg 5185 <210> 901 <211> 6909 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 901 aagatgacgg tttgtcacat ggagttggca ggatgtttga ttaaaaacat aacaggaaga 60 aaaatgcccc gctgtgggcg gacaaaatag ttgggaactg ggaggggtgg aaatggagtt 120 tttaaggatt atttagggaa gagtgacaaa atagatggga actgggtgta gcgtcgtaag 180 ctaatacgaa aattaaaaat gacaaaatag tttggaacta gatttcactt atctggttcg 240 gatctcctag gcgatatcag tgatcacgga tctcgaccaa ttgacattat tgaagcaact 300 agtatcgatt ttatcagggt tattgtctca gacctgcagg cagctgcgcg ctcgctcgct 360 cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt 420 gagcgagcga gcgcgcagag agggagtggc caactccatc actaggggtt cctgtggcca 480 actccatcac taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctacgt 540 agccatgctc tagattaatt aatgcccatg taaggaggca aggcctgggg acacccgaga 600 tgcctggtta taattaaccc agacatgtgg ctgccccccc ccccccaaca cctgctgcct 660 ctaaaaataa ccctgcatgc catgttcccg gcgaagggcc agctgtcccc cgccagctag 720 actcagcact tagtttagga accagtgagc aagtcagccc ttggggcagc ccatacaagg 780 ccatggggct gggcaagctg cacgcctggg tccggggtgg gcacggtgcc cgggcaacga 840 gctgaaagct catctgctct caggggcccc tccctgggga cagcccctcc tggctagtca 900 caccctgtag gctcctctat ataacccagg ggcacagggg ctgccctcat tctaccacca 960 cctccacagc acagacagac actcaggagc cagccagcgc tagcgccacc atgatggccc 1020 caaagaagaa gcggaaggtc ggtatccacg gagtcccagc agccgacaag aagtacagca 1080 tcggcctgga catcggcacc aactctgtgg gctgggccgt gatcaccgac gagtacaagg 1140 tgcccagcaa gaaattcaag gtgctgggca acaccgaccg gcacagcatc aagaagaacc 1200 tgatcggagc cctgctgttc gacagcggcg aaacagccga ggccacccgg ctgaagagaa 1260 ccgccagaag aagatacacc agacggaaga accggatctg ctatctgcaa gagatcttca 1320 gcaacgagat ggccaaggtg gacgacagct tcttccacag actggaagag tccttcctgg 1380 tggaagagga taagaagcac gagcggcacc ccatcttcgg caacatcgtg gacgaggtgg 1440 cctaccacga gaagtacccc accatctacc acctgagaaa gaaactggtg gacagcaccg 1500 acaaggccga cctgcggctg atctatctgg ccctggccca catgatcaag ttccggggcc 1560 acttcctgat cgagggcgac ctgaaccccg acaacagcga cgtggacaag ctgttcatcc 1620 agctggtgca gacctacaac cagctgttcg aggaaaaccc catcaacgcc agcggcgtgg 1680 acgccaaggc catcctgtct gccagactga gcaagagcag acggctggaa aatctgatcg 1740 cccagctgcc cggcgagaag aagaatggcc tgttcggcaa cctgattgcc ctgagcctgg 1800 gcctgacccc caacttcaag agcaacttcg acctggccga ggatgccaaa ctgcagctga 1860 gcaaggacac ctacgacgac gacctggaca acctgctggc ccagatcggc gaccagtacg 1920 ccgacctgtt tctggccgcc aagaacctgt ccgacgccat cctgctgagc gacatcctga 1980 gagtgaacac cgagatcacc aaggcccccc tgagcgcctc tatgatcaag agatacgacg 2040 agcaccacca ggacctgacc ctgctgaaag ctctcgtgcg gcagcagctg cctgagaagt 2100 acaaagagat tttcttcgac cagagcaaga acggctacgc cggctacatt gacggcggag 2160 ccagccagga agagttctac aagttcatca agcccatcct ggaaaagatg gacggcaccg 2220 aggaactgct cgtgaagctg aacagagagg acctgctgcg gaagcagcgg accttcgaca 2280 acggcagcat cccccaccag atccacctgg gagagctgca cgccattctg cggcggcagg 2340 aagattttta cccattcctg aaggacaacc gggaaaagat cgagaagatc ctgaccttcc 2400 gcatccccta ctacgtgggc cctctggcca ggggaaacag cagattcgcc tggatgacca 2460 gaaagagcga ggaaaccatc accccctgga acttcgagga agtggtggac aagggcgctt 2520 ccgcccagag cttcatcgag cggatgacca acttcgataa gaacctgccc aacgagaagg 2580 tgctgcccaa gcacagcctg ctgtacgagt acttcaccgt gtataacgag ctgaccaaag 2640 tgaaatacgt gaccgaggga atgagaaagc ccgccttcct gagcggcgag cagaaaaagg 2700 ccatcgtgga cctgctgttc aagaccaacc ggaaagtgac cgtgaagcag ctgaaagagg 2760 actacttcaa gaaaatcgag tgcttcgact ccgtggaaat ctccggcgtg gaagatcggt 2820 tcaacgcctc cctgggcaca taccacgatc tgctgaaaat tatcaaggac aaggacttcc 2880 tggacaatga ggaaaacgag gacattctgg aagatatcgt gctgaccctg acactgtttg 2940 aggacagaga gatgatcgag gaacggctga aaacctatgc ccacctgttc gacgacaaag 3000 tgatgaagca gctgaagcgg cggagataca ccggctgggg caggctgagc cggaagctga 3060 tcaacggcat ccgggacaag cagtccggca agacaatcct ggatttcctg aagtccgacg 3120 gcttcgccaa cagaaacttc atgcagctga tccacgacga cagcctgacc tttaaagagg 3180 acatccagaa agcccaggtg tccggccagg gcgatagcct gcacgagcac attgccaatc 3240 tggccggcag ccccgccatt aagaagggca tcctgcagac agtgaaggtg gtggacgagc 3300 tcgtgaaagt gatgggccgg cacaagcccg agaacatcgt gatcgaaatg gccagagaga 3360 accagaccac ccagaaggga cagaagaaca gccgcgagag aatgaagcgg atcgaagagg 3420 gcatcaaaga gctgggcagc cagatcctga aagaacaccc cgtggaaaac acccagctgc 3480 agaacgagaa gctgtacctg tactacctgc agaatgggcg ggatatgtac gtggaccagg 3540 aactggacat caaccggctg tccgactacg atgtggacca tatcgtgcct cagagctttc 3600 tgaaggacga ctccatcgac aacaaggtgc tgaccagaag cgacaagaac cggggcaaga 3660 gcgacaacgt gccctccgaa gaggtcgtga agaagatgaa gaactactgg cggcagctgc 3720 tgaacgccaa gctgattacc cagagaaagt tcgacaatct gaccaaggcc gagagaggcg 3780 gcctgagcga actggataag gccggcttca tcaagagaca gctggtggaa acccggcaga 3840 tcacaaagca cgtggcacag atcctggact cccggatgaa cactaagtac gacgagaatg 3900 acaagctgat ccgggaagtg aaagtgatca ccctgaagtc caagctggtg tccgatttcc 3960 ggaaggattt ccagttttac aaagtgcgcg agatcaacaa ctaccaccac gcccacgacg 4020 cctacctgaa cgccgtcgtg ggaaccgccc tgatcaaaaa gtaccctaag ctggaaagcg 4080 agttcgtgta cggcgactac aaggtgtacg acgtgcggaa gatgatcgcc aagagcgagc 4140 aggaaatcgg caaggctacc gccaagtact tcttctacag caacatcatg aactttttca 4200 agaccgagat taccctggcc aacggcgaga tccggaagcg gcctctgatc gagacaaacg 4260 gcgaaaccgg ggagatcgtg tgggataagg gccgggattt tgccaccgtg cggaaagtgc 4320 tgagcatgcc ccaagtgaat atcgtgaaaa agaccgaggt gcagacaggc ggcttcagca 4380 aagagtctat cctgcccaag aggaacagcg ataagctgat cgccagaaag aaggactggg 4440 accctaagaa gtacggcggc ttcgacagcc ccaccgtggc ctattctgtg ctggtggtgg 4500 ccaaagtgga aaagggcaag tccaagaaac tgaagagtgt gaaagagctg ctggggatca 4560 ccatcatgga aagaagcagc ttcgagaaga atcccatcga ctttctggaa gccaagggct 4620 acaaagaagt gaaaaaggac ctgatcatca agctgcctaa gtactccctg ttcgagctgg 4680 aaaacggccg gaagagaatg ctggcctctg ccggcgaact gcagaaggga aacgaactgg 4740 ccctgccctc caaatatgtg aacttcctgt acctggccag ccactatgag aagctgaagg 4800 gctcccccga ggataatgag cagaaacagc tgtttgtgga acagcacaag cactacctgg 4860 acgagatcat cgagcagatc agcgagttct ccaagagagt gatcctggcc gacgctaatc 4920 tggacaaagt gctgtccgcc tacaacaagc accgggataa gcccatcaga gagcaggccg 4980 agaatatcat ccacctgttt accctgacca atctgggagc ccctgccgcc ttcaagtact 5040 ttgacaccac catcgaccgg aagaggtaca ccagcaccaa agaggtgctg gacgccaccc 5100 tgatccacca gagcatcacc ggcctgtacg agacacggat cgacctgtct cagctgggag 5160 gcgacaagcg tcctgctgct actaagaaag ctggtcaagc taagaaaaag aaatgaatcg 5220 attagcaata aaggatcgtt tattttcatt ggaagcgtgt gttggttttt tgatcaggcg 5280 cgggtaccag gtcgcggccg ctctagagca tggctacgta gataagtagc atggcgggtt 5340 aatcattaac tacaaggaac ccctagtgat ggagttagga acccctagtg atggagttgg 5400 ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac 5460 gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc ctgcaggcat 5520 gcaagctgta gccaaccact agaactatag ctagagtcct gggcgaacaa acgatgctcg 5580 ccttccagaa aaccgaggat gcgaaccact tcatccgggg tcagcaccac cggcaagcgc 5640 cgcgacggcc gaggtcttcc gatctcctga agccagggca gatccgtgca cagcaccttg 5700 ccgtagaaga acagcaaggc cgccaatgcc tgacgatgcg tggagaccga aaccttgcgc 5760 tcgttcgcca gccaggacag aaatgcctcg acttcgctgc tgcccaaggt tgccgggtga 5820 cgcacaccgt ggaaacggat gaaggcacga acccagttga cataagcctg ttcggttcgt 5880 aaactgtaat gcaagtagcg tatgcgctca cgcaactggt ccagaacctt gaccgaacgc 5940 agcggtggta acggcgcagt ggcggttttc atggcttgtt atgactgttt ttttgtacag 6000 tctatgcctc gggcatccaa gcagcaagcg cgttacgccg tgggtcgatg tttgatgtta 6060 tggagcagca acgatgttac gcagcagcaa cgatgttacg cagcagggca gtcgccctaa 6120 aacaaagtta ggtggctcaa gtatgggcat cattcgcaca tgtaggctcg gccctgacca 6180 agtcaaatcc atgcgggctg ctcttgatct tttcggtcgt gagttcggag acgtagccac 6240 ctactcccaa catcagccgg actccgatta cctcgggaac ttgctccgta gtaagacatt 6300 catcgcgctt gctgccttcg accaagaagc ggttgttggc gctctcgcgg cttacgttct 6360 gcccaagttt gagcagccgc gtagtgagat ctatatctat gatctcgcag tctccggcga 6420 gcaccggagg cagggcattg ccaccgcgct catcaatctc ctcaagcatg aggccaacgc 6480 gcttggtgct tatgtgatct acgtgcaagc agattacggt gacgatcccg cagtggctct 6540 ctatacaaag ttgggcatac gggaagaagt gatgcacttt gatatcgacc caagtaccgc 6600 cacctaacaa ttcgttcaag ccgagatcgg cttcccggcc gcggagttgt tcggtaaatt 6660 gtcacaacgc cgcgaatata gtctttacca tgcccttggc cacgcccctc tttaatacga 6720 cgggcaattt gcacttcaga aaatgaagag tttgctttag ccataacaaa agtccagtat 6780 gctttttcac agcataactg gactgatttc agtttacaac tattctgtct agtttaagac 6840 tttattgtca tagtttagat ctattttgtt cagtttaaga ctttattgtc cgcccacacc 6900 cgcttacgc 6909 <210> 902 <211> 6857 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 902 aagatgacgg tttgtcacat ggagttggca ggatgtttga ttaaaaacat aacaggaaga 60 aaaatgcccc gctgtgggcg gacaaaatag ttgggaactg ggaggggtgg aaatggagtt 120 tttaaggatt atttagggaa gagtgacaaa atagatggga actgggtgta gcgtcgtaag 180 ctaatacgaa aattaaaaat gacaaaatag tttggaacta gatttcactt atctggttcg 240 gatctcctag gcgatatcag tgatcacgga tctcgaccaa ttgacattat tgaagcaact 300 agtatcgatt ttatcagggt tattgtctca gaggccactc cctctctgcg cgctcgctcg 360 ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca 420 gtgagcgagc gagcgcgcag agagggagtg gccaactcca tcactagggg ttccttgtag 480 ttaatgatta acccgccatg ctacttatct acgtagccat gctctagatt aattaatgcc 540 catgtaagga ggcaaggcct ggggacaccc gagatgcctg gttataatta acccagacat 600 gtggctgccc cccccccccc aacacctgct gcctctaaaa ataaccctgc atgccatgtt 660 cccggcgaag ggccagctgt cccccgccag ctagactcag cacttagttt aggaaccagt 720 gagcaagtca gcccttgggg cagcccatac aaggccatgg ggctgggcaa gctgcacgcc 780 tgggtccggg gtgggcacgg tgcccgggca acgagctgaa agctcatctg ctctcagggg 840 cccctccctg gggacagccc ctcctggcta gtcacaccct gtaggctcct ctatataacc 900 caggggcaca ggggctgccc tcattctacc accacctcca cagcacagac agacactcag 960 gagccagcca gcgctagcgc caccatgatg gccccaaaga agaagcggaa ggtcggtatc 1020 cacggagtcc cagcagccga caagaagtac agcatcggcc tggacatcgg caccaactct 1080 gtgggctggg ccgtgatcac cgacgagtac aaggtgccca gcaagaaatt caaggtgctg 1140 ggcaacaccg accggcacag catcaagaag aacctgatcg gagccctgct gttcgacagc 1200 ggcgaaacag ccgaggccac ccggctgaag agaaccgcca gaagaagata caccagacgg 1260 aagaaccgga tctgctatct gcaagagatc ttcagcaacg agatggccaa ggtggacgac 1320 agcttcttcc acagactgga agagtccttc ctggtggaag aggataagaa gcacgagcgg 1380 caccccatct tcggcaacat cgtggacgag gtggcctacc acgagaagta ccccaccatc 1440 taccacctga gaaagaaact ggtggacagc accgacaagg ccgacctgcg gctgatctat 1500 ctggccctgg cccacatgat caagttccgg ggccacttcc tgatcgaggg cgacctgaac 1560 cccgacaaca gcgacgtgga caagctgttc atccagctgg tgcagaccta caaccagctg 1620 ttcgaggaaa accccatcaa cgccagcggc gtggacgcca aggccatcct gtctgccaga 1680 ctgagcaaga gcagacggct ggaaaatctg atcgcccagc tgcccggcga gaagaagaat 1740 ggcctgttcg gcaacctgat tgccctgagc ctgggcctga cccccaactt caagagcaac 1800 ttcgacctgg ccgaggatgc caaactgcag ctgagcaagg acacctacga cgacgacctg 1860 gacaacctgc tggcccagat cggcgaccag tacgccgacc tgtttctggc cgccaagaac 1920 ctgtccgacg ccatcctgct gagcgacatc ctgagagtga acaccgagat caccaaggcc 1980 cccctgagcg cctctatgat caagagatac gacgagcacc accaggacct gaccctgctg 2040 aaagctctcg tgcggcagca gctgcctgag aagtacaaag agattttctt cgaccagagc 2100 aagaacggct acgccggcta cattgacggc ggagccagcc aggaagagtt ctacaagttc 2160 atcaagccca tcctggaaaa gatggacggc accgaggaac tgctcgtgaa gctgaacaga 2220 gaggacctgc tgcggaagca gcggaccttc gacaacggca gcatccccca ccagatccac 2280 ctgggagagc tgcacgccat tctgcggcgg caggaagatt tttacccatt cctgaaggac 2340 aaccgggaaa agatcgagaa gatcctgacc ttccgcatcc cctactacgt gggccctctg 2400 gccaggggaa acagcagatt cgcctggatg accagaaaga gcgaggaaac catcaccccc 2460 tggaacttcg aggaagtggt ggacaagggc gcttccgccc agagcttcat cgagcggatg 2520 accaacttcg ataagaacct gcccaacgag aaggtgctgc ccaagcacag cctgctgtac 2580 gagtacttca ccgtgtataa cgagctgacc aaagtgaaat acgtgaccga gggaatgaga 2640 aagcccgcct tcctgagcgg cgagcagaaa aaggccatcg tggacctgct gttcaagacc 2700 aaccggaaag tgaccgtgaa gcagctgaaa gaggactact tcaagaaaat cgagtgcttc 2760 gactccgtgg aaatctccgg cgtggaagat cggttcaacg cctccctggg cacataccac 2820 gatctgctga aaattatcaa ggacaaggac ttcctggaca atgaggaaaa cgaggacatt 2880 ctggaagata tcgtgctgac cctgacactg tttgaggaca gagagatgat cgaggaacgg 2940 ctgaaaacct atgcccacct gttcgacgac aaagtgatga agcagctgaa gcggcggaga 3000 tacaccggct ggggcaggct gagccggaag ctgatcaacg gcatccggga caagcagtcc 3060 ggcaagacaa tcctggattt cctgaagtcc gacggcttcg ccaacagaaa cttcatgcag 3120 ctgatccacg acgacagcct gacctttaaa gaggacatcc agaaagccca ggtgtccggc 3180 cagggcgata gcctgcacga gcacattgcc aatctggccg gcagccccgc cattaagaag 3240 ggcatcctgc agacagtgaa ggtggtggac gagctcgtga aagtgatggg ccggcacaag 3300 cccgagaaca tcgtgatcga aatggccaga gagaaccaga ccacccagaa gggacagaag 3360 aacagccgcg agagaatgaa gcggatcgaa gagggcatca aagagctggg cagccagatc 3420 ctgaaagaac accccgtgga aaacacccag ctgcagaacg agaagctgta cctgtactac 3480 ctgcagaatg ggcgggatat gtacgtggac caggaactgg acatcaaccg gctgtccgac 3540 tacgatgtgg accatatcgt gcctcagagc tttctgaagg acgactccat cgacaacaag 3600 gtgctgacca gaagcgacaa gaaccggggc aagagcgaca acgtgccctc cgaagaggtc 3660 gtgaagaaga tgaagaacta ctggcggcag ctgctgaacg ccaagctgat tacccagaga 3720 aagttcgaca atctgaccaa ggccgagaga ggcggcctga gcgaactgga taaggccggc 3780 ttcatcaaga gacagctggt ggaaacccgg cagatcacaa agcacgtggc acagatcctg 3840 gactcccgga tgaacactaa gtacgacgag aatgacaagc tgatccggga agtgaaagtg 3900 atcaccctga agtccaagct ggtgtccgat ttccggaagg atttccagtt ttacaaagtg 3960 cgcgagatca acaactacca ccacgcccac gacgcctacc tgaacgccgt cgtgggaacc 4020 gccctgatca aaaagtaccc taagctggaa agcgagttcg tgtacggcga ctacaaggtg 4080 tacgacgtgc ggaagatgat cgccaagagc gagcaggaaa tcggcaaggc taccgccaag 4140 tacttcttct acagcaacat catgaacttt ttcaagaccg agattaccct ggccaacggc 4200 gagatccgga agcggcctct gatcgagaca aacggcgaaa ccggggagat cgtgtgggat 4260 aagggccggg attttgccac cgtgcggaaa gtgctgagca tgccccaagt gaatatcgtg 4320 aaaaagaccg aggtgcagac aggcggcttc agcaaagagt ctatcctgcc caagaggaac 4380 agcgataagc tgatcgccag aaagaaggac tgggacccta agaagtacgg cggcttcgac 4440 agccccaccg tggcctattc tgtgctggtg gtggccaaag tggaaaaggg caagtccaag 4500 aaactgaaga gtgtgaaaga gctgctgggg atcaccatca tggaaagaag cagcttcgag 4560 aagaatccca tcgactttct ggaagccaag ggctacaaag aagtgaaaaa ggacctgatc 4620 atcaagctgc ctaagtactc cctgttcgag ctggaaaacg gccggaagag aatgctggcc 4680 tctgccggcg aactgcagaa gggaaacgaa ctggccctgc cctccaaata tgtgaacttc 4740 ctgtacctgg ccagccacta tgagaagctg aagggctccc ccgaggataa tgagcagaaa 4800 cagctgtttg tggaacagca caagcactac ctggacgaga tcatcgagca gatcagcgag 4860 ttctccaaga gagtgatcct ggccgacgct aatctggaca aagtgctgtc cgcctacaac 4920 aagcaccggg ataagcccat cagagagcag gccgagaata tcatccacct gtttaccctg 4980 accaatctgg gagcccctgc cgccttcaag tactttgaca ccaccatcga ccggaagagg 5040 tacaccagca ccaaagaggt gctggacgcc accctgatcc accagagcat caccggcctg 5100 tacgagacac ggatcgacct gtctcagctg ggaggcgaca agcgtcctgc tgctactaag 5160 aaagctggtc aagctaagaa aaagaaatga atcgattagc aataaaggat cgtttatttt 5220 cattggaagc gtgtgttggt tttttgatca ggcgcgggta ccaggtcgcg gccgctctag 5280 agcatggcta cgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag 5340 tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa 5400 aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag 5460 agggacatgc aagctgtagc caaccactag aactatagct agagtcctgg gcgaacaaac 5520 gatgctcgcc ttccagaaaa ccgaggatgc gaaccacttc atccggggtc agcaccaccg 5580 gcaagcgccg cgacggccga ggtcttccga tctcctgaag ccagggcaga tccgtgcaca 5640 gcaccttgcc gtagaagaac agcaaggccg ccaatgcctg acgatgcgtg gagaccgaaa 5700 ccttgcgctc gttcgccagc caggacagaa atgcctcgac ttcgctgctg cccaaggttg 5760 ccgggtgacg cacaccgtgg aaacggatga aggcacgaac ccagttgaca taagcctgtt 5820 cggttcgtaa actgtaatgc aagtagcgta tgcgctcacg caactggtcc agaaccttga 5880 ccgaacgcag cggtggtaac ggcgcagtgg cggttttcat ggcttgttat gactgttttt 5940 ttgtacagtc tatgcctcgg gcatccaagc agcaagcgcg ttacgccgtg ggtcgatgtt 6000 tgatgttatg gagcagcaac gatgttacgc agcagcaacg atgttacgca gcagggcagt 6060 cgccctaaaa caaagttagg tggctcaagt atgggcatca ttcgcacatg taggctcggc 6120 cctgaccaag tcaaatccat gcgggctgct cttgatcttt tcggtcgtga gttcggagac 6180 gtagccacct actcccaaca tcagccggac tccgattacc tcgggaactt gctccgtagt 6240 aagacattca tcgcgcttgc tgccttcgac caagaagcgg ttgttggcgc tctcgcggct 6300 tacgttctgc ccaagtttga gcagccgcgt agtgagatct atatctatga tctcgcagtc 6360 tccggcgagc accggaggca gggcattgcc accgcgctca tcaatctcct caagcatgag 6420 gccaacgcgc ttggtgctta tgtgatctac gtgcaagcag attacggtga cgatcccgca 6480 gtggctctct atacaaagtt gggcatacgg gaagaagtga tgcactttga tatcgaccca 6540 agtaccgcca cctaacaatt cgttcaagcc gagatcggct tcccggccgc ggagttgttc 6600 ggtaaattgt cacaacgccg cgaatatagt ctttaccatg cccttggcca cgcccctctt 6660 taatacgacg ggcaatttgc acttcagaaa atgaagagtt tgctttagcc ataacaaaag 6720 tccagtatgc tttttcacag cataactgga ctgatttcag tttacaacta ttctgtctag 6780 tttaagactt tattgtcata gtttagatct attttgttca gtttaagact ttattgtccg 6840 cccacacccg cttacgc 6857 <210> 903 <211> 60 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 903 tagcaataaa ggatcgttta ttttcattgg aagcgtgtgt tggttttttg atcaggcgcg 60 <210> 904 <211> 3 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 904 tag 3 <210> 905 <211> 3 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 905 taa 3 <210> 906 <211> 3 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 906 tga 3 <210> 907 <211> 166 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 907 tgtgggcgga caaaatagtt gggaactggg aggggtggaa atggagtttt taaggattat 60 ttagggaaga gtgacaaaat agatgggaac tgggtgtagc gtcgtaagct aatacgaaaa 120 ttaaaaatga caaaatagtt tggaactaga tttcacttat ctggtt 166 <210> 908 <211> 225 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 908 gaatatagtc tttaccatgc ccttggccac gcccctcttt aatacgacgg gcaatttgca 60 cttcagaaaa tgaagagttt gctttagcca taacaaaagt ccagtatgct ttttcacagc 120 ataactggac tgatttcagt ttacaactat tctgtctagt ttaagacttt attgtcatag 180 tttagatcta ttttgttcag tttaagactt tattgtccgc ccaca 225 <210> 909 <211> 1155 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 909 catgcaagct gtagccaacc actagaacta tagctagagt cctgggcgaa caaacgatgc 60 tcgccttcca gaaaaccgag gatgcgaacc acttcatccg gggtcagcac caccggcaag 120 cgccgcgacg gccgaggtct tccgatctcc tgaagccagg gcagatccgt gcacagcacc 180 ttgccgtaga agaacagcaa ggccgccaat gcctgacgat gcgtggagac cgaaaccttg 240 cgctcgttcg ccagccagga cagaaatgcc tcgacttcgc tgctgcccaa ggttgccggg 300 tgacgcacac cgtggaaacg gatgaaggca cgaacccagt tgacataagc ctgttcggtt 360 cgtaaactgt aatgcaagta gcgtatgcgc tcacgcaact ggtccagaac cttgaccgaa 420 cgcagcggtg gtaacggcgc agtggcggtt ttcatggctt gttatgactg tttttttgta 480 cagtctatgc ctcgggcatc caagcagcaa gcgcgttacg ccgtgggtcg atgtttgatg 540 ttatggagca gcaacgatgt tacgcagcag caacgatgtt acgcagcagg gcagtcgccc 600 taaaacaaag ttaggtggct caagtatggg catcattcgc acatgtaggc tcggccctga 660 ccaagtcaaa tccatgcggg ctgctcttga tcttttcggt cgtgagttcg gagacgtagc 720 cacctactcc caacatcagc cggactccga ttacctcggg aacttgctcc gtagtaagac 780 attcatcgcg cttgctgcct tcgaccaaga agcggttgtt ggcgctctcg cggcttacgt 840 tctgcccaag tttgagcagc cgcgtagtga gatctatatc tatgatctcg cagtctccgg 900 cgagcaccgg aggcagggca ttgccaccgc gctcatcaat ctcctcaagc atgaggccaa 960 cgcgcttggt gcttatgtga tctacgtgca agcagattac ggtgacgatc ccgcagtggc 1020 tctctataca aagttgggca tacgggaaga agtgatgcac tttgatatcg acccaagtac 1080 cgccacctaa caattcgttc aagccgagat cggcttcccg gccgcggagt tgttcggtaa 1140 attgtcacaa cgccg 1155 <210> 910 <211> 2861 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 910 ccactccctc tatgcgcgct cgctcactca ctcggccctg gagaccaaag gtctccagac 60 tgccggcctc tggccggcag ggccgagtga gtgagcgagc gcgcatagag ggagtgggta 120 cctccatcat ctaggtttgc cagatctgat atcggcgcgc ccctgggcgc gcccgagtcc 180 aacacccgtg ggaatcccat gggcaccatg gcccctcgct ccaaaaatgc tttcgcgtcg 240 cgcagacact gctcggtagt ttcggggatc agcgtttgag taagagcccg cgtctgaacc 300 ctccgcgccg ccccggcccc agtggaaaga cgcgcaggca aaacgcacca cgtgacggag 360 cgtgaccgcg cgccgagcgc gcgccaaggt cgggcaggaa gagggcctat ttcccatgat 420 tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa ttaatttgac 480 tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta 540 gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa 600 gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacaccg cactagagta 660 acagtctgac gtttaagagc tatgctggaa acagcatagc aagtttaaat aaggctagtc 720 cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tttgcggccg cgctcggcgc 780 gcccatattt gcatgtcgct atgtgttctg ggaaatcacc ataaacgtga aatgtctttg 840 gatttgggaa tcttataagt tctgtatgag accacggtac accgcactag agtaacagtc 900 tgacgtttaa gagctatgct ggaaacagca tagcaagttt aaataaggct agtccgttat 960 caacttgaaa aagtggcacc gagtcggtgc tttttttgcg gccgctgacg gcgcgccctg 1020 cagtatttag catgccccac ccatctgcaa ggcattctgg atagtgtcaa aacagccgga 1080 aatcaagtcc gtttatctca aactttagca ttttgggaat aaatgatatt tgctatgctg 1140 gttaaattag attttagtta aatttcctgc tgaagctcta gtacgataag taacttgacc 1200 taagtgtaaa gttgagattt ccttcaggtt tatatagctt gtgcgccgcc tgggtacacc 1260 gcactagagt aacagtctga cgtttaagag ctatgctgga aacagcatag caagtttaaa 1320 taaggctagt ccgttatcaa cttgaaaaag tggcaccgag tcggtgcttt ttttgcggcc 1380 gcgcttgcgg ccgcctcgag tgatcaaaaa aaccaacaca cgcttccaat gaaaataaac 1440 gatcctttat tgctagcctt tacttgtaca gctcgtccat gccgagagtg atcccggcgg 1500 cggtcacgaa ctccagcagg accatgtgat cgcgcttctc gttggggtct ttgctcaggg 1560 cggactgggt gctcaggtag tggttgtcgg gcagcaacac ggggccgtcg ccgatggggg 1620 tgttctgctg gtagtggtcg gcgagctgca cgctgccgtc ctcgatgttg tggcggatct 1680 tgaagttcac cttgatgccg ttcttctgct tgtcggccat gatatagacg ttgtggctgt 1740 tgtagttgta ctccagcttg tgccccagga tgttgccgtc ctccttgaag tcgatgccct 1800 tcagctcgat gcggttcacc agggtgtcgc cctcgaactt cacctcggcg cgggtcttgt 1860 agttgccgtc gtccttgaag aagatggtgc gctcctggac gtagccttcg ggcatggcgg 1920 acttgaagaa gtcgtgctgc ttcatgtggt cggggtagcg gctgaagcac tgcacgccgt 1980 aggtcagggt ggtcacgagg gtgggccagg gcacgggcag cttgccggtg gtgcagatga 2040 acttcagggt cagcttgccg taggtggcat cgccctcgcc ctcgccggac acgctgaact 2100 tgtggccgtt tacgtcgccg tccagctcga ccaggatggg caccaccccg gtgaacagct 2160 cctcgccctt gctcaccatg gtggcgaccg gtggatcccg ggcccgcggg gtggctttac 2220 caacagtacc cggaatgcca agcttactta gatcgcagtc tcgacgctgg ctggctcctg 2280 agtgtctgtc tgtgctgtgg aggtggtggt agaatgaggg cagcccctgt gcccctgggt 2340 tatatagagg agcctacagg gtgtgactag ccaggagggg ctgtccccag ggaggggccc 2400 ctgagagcag atgagctttc agctcgttgc ccgggcaccg tgcccacccc ggacccaggc 2460 gtgcagcttg cccagcccca tggccttgta tgggctgccc caagggctga cttgctcact 2520 ggttcctaaa ctaagtgctg agtctagctg gcgggggaca gctggccctt cgccgggaac 2580 atggcatgca gggttatttt tagaggcagc aggtgttggg gggggggggg cagccacatg 2640 tctgggttaa ttataaccag gcatctcggg tgtccccagg ccttgcctcc ttacatgggc 2700 acgtcgacga tatcagatct aggaacccct agtgatggag ttggccactc cctctctgcg 2760 cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg 2820 cccggcctca gtgagcgagc gagcgcgcag agagggagtg g 2861 <210> 911 <211> 2861 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 911 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc tagatctgat atcggcgcgc ccctgggcgc gcccgagtcc 180 aacacccgtg ggaatcccat gggcaccatg gcccctcgct ccaaaaatgc tttcgcgtcg 240 cgcagacact gctcggtagt ttcggggatc agcgtttgag taagagcccg cgtctgaacc 300 ctccgcgccg ccccggcccc agtggaaaga cgcgcaggca aaacgcacca cgtgacggag 360 cgtgaccgcg cgccgagcgc gcgccaaggt cgggcaggaa gagggcctat ttcccatgat 420 tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa ttaatttgac 480 tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta 540 gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa 600 gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacaccg cactagagta 660 acagtctgac gtttaagagc tatgctggaa acagcatagc aagtttaaat aaggctagtc 720 cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tttgcggccg cgctcggcgc 780 gcccatattt gcatgtcgct atgtgttctg ggaaatcacc ataaacgtga aatgtctttg 840 gatttgggaa tcttataagt tctgtatgag accacggtac accgcactag agtaacagtc 900 tgacgtttaa gagctatgct ggaaacagca tagcaagttt aaataaggct agtccgttat 960 caacttgaaa aagtggcacc gagtcggtgc tttttttgcg gccgctgacg gcgcgccctg 1020 cagtatttag catgccccac ccatctgcaa ggcattctgg atagtgtcaa aacagccgga 1080 aatcaagtcc gtttatctca aactttagca ttttgggaat aaatgatatt tgctatgctg 1140 gttaaattag attttagtta aatttcctgc tgaagctcta gtacgataag taacttgacc 1200 taagtgtaaa gttgagattt ccttcaggtt tatatagctt gtgcgccgcc tgggtacacc 1260 gcactagagt aacagtctga cgtttaagag ctatgctgga aacagcatag caagtttaaa 1320 taaggctagt ccgttatcaa cttgaaaaag tggcaccgag tcggtgcttt ttttgcggcc 1380 gcgcttgcgg ccgcctcgag tgatcaaaaa aaccaacaca cgcttccaat gaaaataaac 1440 gatcctttat tgctagcctt tacttgtaca gctcgtccat gccgagagtg atcccggcgg 1500 cggtcacgaa ctccagcagg accatgtgat cgcgcttctc gttggggtct ttgctcaggg 1560 cggactgggt gctcaggtag tggttgtcgg gcagcaacac ggggccgtcg ccgatggggg 1620 tgttctgctg gtagtggtcg gcgagctgca cgctgccgtc ctcgatgttg tggcggatct 1680 tgaagttcac cttgatgccg ttcttctgct tgtcggccat gatatagacg ttgtggctgt 1740 tgtagttgta ctccagcttg tgccccagga tgttgccgtc ctccttgaag tcgatgccct 1800 tcagctcgat gcggttcacc agggtgtcgc cctcgaactt cacctcggcg cgggtcttgt 1860 agttgccgtc gtccttgaag aagatggtgc gctcctggac gtagccttcg ggcatggcgg 1920 acttgaagaa gtcgtgctgc ttcatgtggt cggggtagcg gctgaagcac tgcacgccgt 1980 aggtcagggt ggtcacgagg gtgggccagg gcacgggcag cttgccggtg gtgcagatga 2040 acttcagggt cagcttgccg taggtggcat cgccctcgcc ctcgccggac acgctgaact 2100 tgtggccgtt tacgtcgccg tccagctcga ccaggatggg caccaccccg gtgaacagct 2160 cctcgccctt gctcaccatg gtggcgaccg gtggatcccg ggcccgcggg gtggctttac 2220 caacagtacc cggaatgcca agcttactta gatcgcagtc tcgacgctgg ctggctcctg 2280 agtgtctgtc tgtgctgtgg aggtggtggt agaatgaggg cagcccctgt gcccctgggt 2340 tatatagagg agcctacagg gtgtgactag ccaggagggg ctgtccccag ggaggggccc 2400 ctgagagcag atgagctttc agctcgttgc ccgggcaccg tgcccacccc ggacccaggc 2460 gtgcagcttg cccagcccca tggccttgta tgggctgccc caagggctga cttgctcact 2520 ggttcctaaa ctaagtgctg agtctagctg gcgggggaca gctggccctt cgccgggaac 2580 atggcatgca gggttatttt tagaggcagc aggtgttggg gggggggggg cagccacatg 2640 tctgggttaa ttataaccag gcatctcggg tgtccccagg ccttgcctcc ttacatgggc 2700 acgtcgacga tatcagatct aggaacccct agtgatggag ttggccactc cctctctgcg 2760 cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg 2820 ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag g 2861 <210> 912 <211> 4585 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 912 aagatgacgg tttgtcacat ggagttggca ggatgtttga ttaaaaacat aacaggaaga 60 aaaatgcccc gctgtgggcg gacaaaatag ttgggaactg ggaggggtgg aaatggagtt 120 tttaaggatt atttagggaa gagtgacaaa atagatggga actgggtgta gcgtcgtaag 180 ctaatacgaa aattaaaaat gacaaaatag tttggaacta gatttcactt atctggttcg 240 gatctcctag gcgatatcag tgatcacgga tctcgaccaa ttgacattat tgaagcaact 300 agtatcgatt ttatcagggt tattgtctca gacctgcagg cagctgcgcg ctcgctcgct 360 cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt 420 gagcgagcga gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg 480 atatcggcgc gcccctgggc gcgcccgagt ccaacacccg tgggaatccc atgggcacca 540 tggcccctcg ctccaaaaat gctttcgcgt cgcgcagaca ctgctcggta gtttcgggga 600 tcagcgtttg agtaagagcc cgcgtctgaa ccctccgcgc cgccccggcc ccagtggaaa 660 gacgcgcagg caaaacgcac cacgtgacgg agcgtgaccg cgcgccgagc gcgcgccaag 720 gtcgggcagg aagagggcct atttcccatg attccttcat atttgcatat acgatacaag 780 gctgttagag agataattag aattaatttg actgtaaaca caaagatatt agtacaaaat 840 acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa 900 atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc 960 ttgtggaaag gacgaaacac cgcactagag taacagtctg acgtttaaga gctatgctgg 1020 aaacagcata gcaagtttaa ataaggctag tccgttatca acttgaaaaa gtggcaccga 1080 gtcggtgctt tttttgcggc cgcgcttcgg cgcgcccata tttgcatgtc gctatgtgtt 1140 ctgggaaatc accataaacg tgaaatgtct ttggatttgg gaatcttata agttctgtat 1200 gagaccacgg tacaccgcac tagagtaaca gtctgacgtt taagagctat gctggaaaca 1260 gcatagcaag tttaaataag gctagtccgt tatcaacttg aaaaagtggc accgagtcgg 1320 tgcttttttt gcggccgctg acggcgcgcc ctgcagtatt tagcatgccc cacccatctg 1380 caaggcattc tggatagtgt caaaacagcc ggaaatcaag tccgtttatc tcaaacttta 1440 gcattttggg aataaatgat atttgctatg ctggttaaat tagattttag ttaaatttcc 1500 tgctgaagct ctagtacgat aagtaacttg acctaagtgt aaagttgaga tttccttcag 1560 gtttatatag cttgtgcgcc gcctgggtac accgcactag agtaacagtc tgacgtttaa 1620 gagctatgct ggaaacagca tagcaagttt aaataaggct agtccgttat caacttgaaa 1680 aagtggcacc gagtcggtgc tttttttgcg gccgcgctgc ggccgcctcg agtgatcaaa 1740 aaaaccaaca cacgcttcca atgaaaataa acgatccttt attgctagcc tttacttgta 1800 cagctcgtcc atgccgagag tgatcccggc ggcggtcacg aactccagca ggaccatgtg 1860 atcgcgcttc tcgttggggt ctttgctcag ggcggactgg gtgctcaggt agtggttgtc 1920 gggcagcaac acggggccgt cgccgatggg ggtgttctgc tggtagtggt cggcgagctg 1980 cacgctgccg tcctcgatgt tgtggcggat cttgaagttc accttgatgc cgttcttctg 2040 cttgtcggcc atgatataga cgttgtggct gttgtagttg tactccagct tgtgccccag 2100 gatgttgccg tcctccttga agtcgatgcc cttcagctcg atgcggttca ccagggtgtc 2160 gccctcgaac ttcacctcgg cgcgggtctt gtagttgccg tcgtccttga agaagatggt 2220 gcgctcctgg acgtagcctt cgggcatggc ggacttgaag aagtcgtgct gcttcatgtg 2280 gtcggggtag cggctgaagc actgcacgcc gtaggtcagg gtggtcacga gggtgggcca 2340 gggcacgggc agcttgccgg tggtgcagat gaacttcagg gtcagcttgc cgtaggtggc 2400 atcgccctcg ccctcgccgg acacgctgaa cttgtggccg tttacgtcgc cgtccagctc 2460 gaccaggatg ggcaccaccc cggtgaacag ctcctcgccc ttgctcacca tggtggcgac 2520 cggtggatcc cgggcccgcg gggtggcttt accaacagta cccggaatgc caagcttact 2580 tagatcgcag tctcgacgct ggctggctcc tgagtgtctg tctgtgctgt ggaggtggtg 2640 gtagaatgag ggcagcccct gtgcccctgg gttatataga ggagcctaca gggtgtgact 2700 agccaggagg ggctgtcccc agggaggggc ccctgagagc agatgagctt tcagctcgtt 2760 gcccgggcac cgtgcccacc ccggacccag gcgtgcagct tgcccagccc catggccttg 2820 tatgggctgc cccaagggct gacttgctca ctggttccta aactaagtgc tgagtctagc 2880 tggcggggga cagctggccc ttcgccggga acatggcatg cagggttatt tttagaggca 2940 gcaggtgttg gggggggggg ggcagccaca tgtctgggtt aattataacc aggcatctcg 3000 ggtgtcccca ggccttgcct ccttacatgg gcacgtcgac gatatcagat ctaggaaccc 3060 ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga 3120 ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc 3180 agctgcctgc aggcatgcaa gctgtagcca accactagaa ctatagctag agtcctgggc 3240 gaacaaacga tgctcgcctt ccagaaaacc gaggatgcga accacttcat ccggggtcag 3300 caccaccggc aagcgccgcg acggccgagg tcttccgatc tcctgaagcc agggcagatc 3360 cgtgcacagc accttgccgt agaagaacag caaggccgcc aatgcctgac gatgcgtgga 3420 gaccgaaacc ttgcgctcgt tcgccagcca ggacagaaat gcctcgactt cgctgctgcc 3480 caaggttgcc gggtgacgca caccgtggaa acggatgaag gcacgaaccc agttgacata 3540 agcctgttcg gttcgtaaac tgtaatgcaa gtagcgtatg cgctcacgca actggtccag 3600 aaccttgacc gaacgcagcg gtggtaacgg cgcagtggcg gttttcatgg cttgttatga 3660 ctgttttttt gtacagtcta tgcctcgggc atccaagcag caagcgcgtt acgccgtggg 3720 tcgatgtttg atgttatgga gcagcaacga tgttacgcag cagcaacgat gttacgcagc 3780 agggcagtcg ccctaaaaca aagttaggtg gctcaagtat gggcatcatt cgcacatgta 3840 ggctcggccc tgaccaagtc aaatccatgc gggctgctct tgatcttttc ggtcgtgagt 3900 tcggagacgt agccacctac tcccaacatc agccggactc cgattacctc gggaacttgc 3960 tccgtagtaa gacattcatc gcgcttgctg ccttcgacca agaagcggtt gttggcgctc 4020 tcgcggctta cgttctgccc aagtttgagc agccgcgtag tgagatctat atctatgatc 4080 tcgcagtctc cggcgagcac cggaggcagg gcattgccac cgcgctcatc aatctcctca 4140 agcatgaggc caacgcgctt ggtgcttatg tgatctacgt gcaagcagat tacggtgacg 4200 atcccgcagt ggctctctat acaaagttgg gcatacggga agaagtgatg cactttgata 4260 tcgacccaag taccgccacc taacaattcg ttcaagccga gatcggcttc ccggccgcgg 4320 agttgttcgg taaattgtca caacgccgcg aatatagtct ttaccatgcc cttggccacg 4380 cccctcttta atacgacggg caatttgcac ttcagaaaat gaagagtttg ctttagccat 4440 aacaaaagtc cagtatgctt tttcacagca taactggact gatttcagtt tacaactatt 4500 ctgtctagtt taagacttta ttgtcatagt ttagatctat tttgttcagt ttaagacttt 4560 attgtccgcc cacacccgct tacgc 4585 <210> 913 <211> 4585 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 913 aagatgacgg tttgtcacat ggagttggca ggatgtttga ttaaaaacat aacaggaaga 60 aaaatgcccc gctgtgggcg gacaaaatag ttgggaactg ggaggggtgg aaatggagtt 120 tttaaggatt atttagggaa gagtgacaaa atagatggga actgggtgta gcgtcgtaag 180 ctaatacgaa aattaaaaat gacaaaatag tttggaacta gatttcactt atctggttcg 240 gatctcctag gcgatatcag tgatcacgga tctcgaccaa ttgacattat tgaagcaact 300 agtatcgatt ttatcagggt tattgtctca gaccactccc tctatgcgcg ctcgctcact 360 cactcggccc tggagaccaa aggtctccag actgccggcc tctggccggc agggccgagt 420 gagtgagcga gcgcgcatag agggagtggg tacctccatc atctaggttt gccagatctg 480 atatcggcgc gcccctgggc gcgcccgagt ccaacacccg tgggaatccc atgggcacca 540 tggcccctcg ctccaaaaat gctttcgcgt cgcgcagaca ctgctcggta gtttcgggga 600 tcagcgtttg agtaagagcc cgcgtctgaa ccctccgcgc cgccccggcc ccagtggaaa 660 gacgcgcagg caaaacgcac cacgtgacgg agcgtgaccg cgcgccgagc gcgcgccaag 720 gtcgggcagg aagagggcct atttcccatg attccttcat atttgcatat acgatacaag 780 gctgttagag agataattag aattaatttg actgtaaaca caaagatatt agtacaaaat 840 acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa 900 atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc 960 ttgtggaaag gacgaaacac cgcactagag taacagtctg acgtttaaga gctatgctgg 1020 aaacagcata gcaagtttaa ataaggctag tccgttatca acttgaaaaa gtggcaccga 1080 gtcggtgctt tttttgcggc cgcgcttcgg cgcgcccata tttgcatgtc gctatgtgtt 1140 ctgggaaatc accataaacg tgaaatgtct ttggatttgg gaatcttata agttctgtat 1200 gagaccacgg tacaccgcac tagagtaaca gtctgacgtt taagagctat gctggaaaca 1260 gcatagcaag tttaaataag gctagtccgt tatcaacttg aaaaagtggc accgagtcgg 1320 tgcttttttt gcggccgctg acggcgcgcc ctgcagtatt tagcatgccc cacccatctg 1380 caaggcattc tggatagtgt caaaacagcc ggaaatcaag tccgtttatc tcaaacttta 1440 gcattttggg aataaatgat atttgctatg ctggttaaat tagattttag ttaaatttcc 1500 tgctgaagct ctagtacgat aagtaacttg acctaagtgt aaagttgaga tttccttcag 1560 gtttatatag cttgtgcgcc gcctgggtac accgcactag agtaacagtc tgacgtttaa 1620 gagctatgct ggaaacagca tagcaagttt aaataaggct agtccgttat caacttgaaa 1680 aagtggcacc gagtcggtgc tttttttgcg gccgcgctgc ggccgcctcg agtgatcaaa 1740 aaaaccaaca cacgcttcca atgaaaataa acgatccttt attgctagcc tttacttgta 1800 cagctcgtcc atgccgagag tgatcccggc ggcggtcacg aactccagca ggaccatgtg 1860 atcgcgcttc tcgttggggt ctttgctcag ggcggactgg gtgctcaggt agtggttgtc 1920 gggcagcaac acggggccgt cgccgatggg ggtgttctgc tggtagtggt cggcgagctg 1980 cacgctgccg tcctcgatgt tgtggcggat cttgaagttc accttgatgc cgttcttctg 2040 cttgtcggcc atgatataga cgttgtggct gttgtagttg tactccagct tgtgccccag 2100 gatgttgccg tcctccttga agtcgatgcc cttcagctcg atgcggttca ccagggtgtc 2160 gccctcgaac ttcacctcgg cgcgggtctt gtagttgccg tcgtccttga agaagatggt 2220 gcgctcctgg acgtagcctt cgggcatggc ggacttgaag aagtcgtgct gcttcatgtg 2280 gtcggggtag cggctgaagc actgcacgcc gtaggtcagg gtggtcacga gggtgggcca 2340 gggcacgggc agcttgccgg tggtgcagat gaacttcagg gtcagcttgc cgtaggtggc 2400 atcgccctcg ccctcgccgg acacgctgaa cttgtggccg tttacgtcgc cgtccagctc 2460 gaccaggatg ggcaccaccc cggtgaacag ctcctcgccc ttgctcacca tggtggcgac 2520 cggtggatcc cgggcccgcg gggtggcttt accaacagta cccggaatgc caagcttact 2580 tagatcgcag tctcgacgct ggctggctcc tgagtgtctg tctgtgctgt ggaggtggtg 2640 gtagaatgag ggcagcccct gtgcccctgg gttatataga ggagcctaca gggtgtgact 2700 agccaggagg ggctgtcccc agggaggggc ccctgagagc agatgagctt tcagctcgtt 2760 gcccgggcac cgtgcccacc ccggacccag gcgtgcagct tgcccagccc catggccttg 2820 tatgggctgc cccaagggct gacttgctca ctggttccta aactaagtgc tgagtctagc 2880 tggcggggga cagctggccc ttcgccggga acatggcatg cagggttatt tttagaggca 2940 gcaggtgttg gggggggggg ggcagccaca tgtctgggtt aattataacc aggcatctcg 3000 ggtgtcccca ggccttgcct ccttacatgg gcacgtcgac gatatcagat ctaggaaccc 3060 ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga ggccgcccgg 3120 gcaaagcccg ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc 3180 agagagggag tggcatgcaa gctgtagcca accactagaa ctatagctag agtcctgggc 3240 gaacaaacga tgctcgcctt ccagaaaacc gaggatgcga accacttcat ccggggtcag 3300 caccaccggc aagcgccgcg acggccgagg tcttccgatc tcctgaagcc agggcagatc 3360 cgtgcacagc accttgccgt agaagaacag caaggccgcc aatgcctgac gatgcgtgga 3420 gaccgaaacc ttgcgctcgt tcgccagcca ggacagaaat gcctcgactt cgctgctgcc 3480 caaggttgcc gggtgacgca caccgtggaa acggatgaag gcacgaaccc agttgacata 3540 agcctgttcg gttcgtaaac tgtaatgcaa gtagcgtatg cgctcacgca actggtccag 3600 aaccttgacc gaacgcagcg gtggtaacgg cgcagtggcg gttttcatgg cttgttatga 3660 ctgttttttt gtacagtcta tgcctcgggc atccaagcag caagcgcgtt acgccgtggg 3720 tcgatgtttg atgttatgga gcagcaacga tgttacgcag cagcaacgat gttacgcagc 3780 agggcagtcg ccctaaaaca aagttaggtg gctcaagtat gggcatcatt cgcacatgta 3840 ggctcggccc tgaccaagtc aaatccatgc gggctgctct tgatcttttc ggtcgtgagt 3900 tcggagacgt agccacctac tcccaacatc agccggactc cgattacctc gggaacttgc 3960 tccgtagtaa gacattcatc gcgcttgctg ccttcgacca agaagcggtt gttggcgctc 4020 tcgcggctta cgttctgccc aagtttgagc agccgcgtag tgagatctat atctatgatc 4080 tcgcagtctc cggcgagcac cggaggcagg gcattgccac cgcgctcatc aatctcctca 4140 agcatgaggc caacgcgctt ggtgcttatg tgatctacgt gcaagcagat tacggtgacg 4200 atcccgcagt ggctctctat acaaagttgg gcatacggga agaagtgatg cactttgata 4260 tcgacccaag taccgccacc taacaattcg ttcaagccga gatcggcttc ccggccgcgg 4320 agttgttcgg taaattgtca caacgccgcg aatatagtct ttaccatgcc cttggccacg 4380 cccctcttta atacgacggg caatttgcac ttcagaaaat gaagagtttg ctttagccat 4440 aacaaaagtc cagtatgctt tttcacagca taactggact gatttcagtt tacaactatt 4500 ctgtctagtt taagacttta ttgtcatagt ttagatctat tttgttcagt ttaagacttt 4560 attgtccgcc cacacccgct tacgc 4585 <210> 914 <211> 2285 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 914 ccactccctc tatgcgcgct cgctcactca ctcggccctg gagaccaaag gtctccagac 60 tgccggcctc tggccggcag ggccgagtga gtgagcgagc gcgcatagag ggagtgggta 120 cctccatcat ctaggtttgc cagatctgat atcggcgcgc ccctgggcgc gcccgagtcc 180 aacacccgtg ggaatcccat gggcaccatg gcccctcgct ccaaaaatgc tttcgcgtcg 240 cgcagacact gctcggtagt ttcggggatc agcgtttgag taagagcccg cgtctgaacc 300 ctccgcgccg ccccggcccc agtggaaaga cgcgcaggca aaacgcacca cgtgacggag 360 cgtgaccgcg cgccgagcgc gcgccaaggt cgggcaggaa gagggcctat ttcccatgat 420 tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa ttaatttgac 480 tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta 540 gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa 600 gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacaccg caccagagta 660 acagtctgag gtttaagagc tatgctggaa acagcatagc aagtttaaat aaggctagtc 720 cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tttgcggccg cgctcggcgc 780 gcccatattt gcatgtcgct atgtgttctg ggaaatcacc ataaacgtga aatgtctttg 840 gatttgggaa tcttataagt tctgtatgag accacggtac accgcaccag agtaacagtc 900 tgaggtttaa gagctatgct ggaaacagca tagcaagttt aaataaggct agtccgttat 960 caacttgaaa aagtggcacc gagtcggtgc tttttttgcg gccgctgacg gcgcgccctg 1020 cagtatttag catgccccac ccatctgcaa ggcattctgg atagtgtcaa aacagccgga 1080 aatcaagtcc gtttatctca aactttagca ttttgggaat aaatgatatt tgctatgctg 1140 gttaaattag attttagtta aatttcctgc tgaagctcta gtacgataag taacttgacc 1200 taagtgtaaa gttgagattt ccttcaggtt tatatagctt gtgcgccgcc tgggtacacc 1260 gcaccagagt aacagtctga ggtttaagag ctatgctgga aacagcatag caagtttaaa 1320 taaggctagt ccgttatcaa cttgaaaaag tggcaccgag tcggtgcttt ttttgcggcc 1380 gcgctgttta aaccaacaaa atcagcagct aatgaaggca agtcagcagg tcactcatca 1440 ttttccactt cggcaatgca gtgggattat tccaacagag gtttttcaca gcattccttc 1500 agttaactgg agatcgaatc ttgattttca cagatatact tggcaaggtc cgccctgtca 1560 tcagcacatt caagcagatc tccatggcag cattccgtgt ggacttaggt aagatctgtc 1620 actaacttgg aaacttctgc aaactcagct tagggaaatc tctggctcag gcgagctact 1680 gcctcagctt agaaagctct ttctccaaat tattggagac tggcacactt aagtccctgt 1740 taggcagacg aagccttccc ttcatcccga agttcatcga gctttggcaa caggcaggca 1800 gctttatcag cagcttggca acattctgta aaagcagctt tataccttta agcaaagaaa 1860 aggagttccg gggcataaaa gtaaggatgt cttctggcaa tttataataa gtattttttc 1920 aaaaatgtct cttcattgtc atgaaaagca gtgcatcaca catcaacctc tggtctcacc 1980 aatcggggga ggtttgggtt gtttacttag tgttgcaaga attattttat tctctcaggt 2040 tcttgttttg cacagcagtc agctcattca ccataggttt cacgaagagt tgctgcggcc 2100 gcctcgataa tacgactcac tatagggtcg acgatatcag atctaggaac ccctagtgat 2160 ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgccc gggcaaagcc 2220 cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc gcagagaggg 2280 agtgg 2285 <210> 915 <211> 2285 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 915 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc tagatctgat atcggcgcgc ccctgggcgc gcccgagtcc 180 aacacccgtg ggaatcccat gggcaccatg gcccctcgct ccaaaaatgc tttcgcgtcg 240 cgcagacact gctcggtagt ttcggggatc agcgtttgag taagagcccg cgtctgaacc 300 ctccgcgccg ccccggcccc agtggaaaga cgcgcaggca aaacgcacca cgtgacggag 360 cgtgaccgcg cgccgagcgc gcgccaaggt cgggcaggaa gagggcctat ttcccatgat 420 tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa ttaatttgac 480 tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta 540 gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa 600 gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacaccg caccagagta 660 acagtctgag gtttaagagc tatgctggaa acagcatagc aagtttaaat aaggctagtc 720 cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tttgcggccg cgctcggcgc 780 gcccatattt gcatgtcgct atgtgttctg ggaaatcacc ataaacgtga aatgtctttg 840 gatttgggaa tcttataagt tctgtatgag accacggtac accgcaccag agtaacagtc 900 tgaggtttaa gagctatgct ggaaacagca tagcaagttt aaataaggct agtccgttat 960 caacttgaaa aagtggcacc gagtcggtgc tttttttgcg gccgctgacg gcgcgccctg 1020 cagtatttag catgccccac ccatctgcaa ggcattctgg atagtgtcaa aacagccgga 1080 aatcaagtcc gtttatctca aactttagca ttttgggaat aaatgatatt tgctatgctg 1140 gttaaattag attttagtta aatttcctgc tgaagctcta gtacgataag taacttgacc 1200 taagtgtaaa gttgagattt ccttcaggtt tatatagctt gtgcgccgcc tgggtacacc 1260 gcaccagagt aacagtctga ggtttaagag ctatgctgga aacagcatag caagtttaaa 1320 taaggctagt ccgttatcaa cttgaaaaag tggcaccgag tcggtgcttt ttttgcggcc 1380 gcgctgttta aaccaacaaa atcagcagct aatgaaggca agtcagcagg tcactcatca 1440 ttttccactt cggcaatgca gtgggattat tccaacagag gtttttcaca gcattccttc 1500 agttaactgg agatcgaatc ttgattttca cagatatact tggcaaggtc cgccctgtca 1560 tcagcacatt caagcagatc tccatggcag cattccgtgt ggacttaggt aagatctgtc 1620 actaacttgg aaacttctgc aaactcagct tagggaaatc tctggctcag gcgagctact 1680 gcctcagctt agaaagctct ttctccaaat tattggagac tggcacactt aagtccctgt 1740 taggcagacg aagccttccc ttcatcccga agttcatcga gctttggcaa caggcaggca 1800 gctttatcag cagcttggca acattctgta aaagcagctt tataccttta agcaaagaaa 1860 aggagttccg gggcataaaa gtaaggatgt cttctggcaa tttataataa gtattttttc 1920 aaaaatgtct cttcattgtc atgaaaagca gtgcatcaca catcaacctc tggtctcacc 1980 aatcggggga ggtttgggtt gtttacttag tgttgcaaga attattttat tctctcaggt 2040 tcttgttttg cacagcagtc agctcattca ccataggttt cacgaagagt tgctgcggcc 2100 gcctcgataa tacgactcac tatagggtcg acgatatcag atctaggaac ccctagtgat 2160 ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt 2220 cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct 2280 gcagg 2285 <210> 916 <211> 4009 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 916 aagatgacgg tttgtcacat ggagttggca ggatgtttga ttaaaaacat aacaggaaga 60 aaaatgcccc gctgtgggcg gacaaaatag ttgggaactg ggaggggtgg aaatggagtt 120 tttaaggatt atttagggaa gagtgacaaa atagatggga actgggtgta gcgtcgtaag 180 ctaatacgaa aattaaaaat gacaaaatag tttggaacta gatttcactt atctggttcg 240 gatctcctag gcgatatcag tgatcacgga tctcgaccaa ttgacattat tgaagcaact 300 agtatcgatt ttatcagggt tattgtctca gacctgcagg cagctgcgcg ctcgctcgct 360 cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt 420 gagcgagcga gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg 480 atatcggcgc gcccctgggc gcgcccgagt ccaacacccg tgggaatccc atgggcacca 540 tggcccctcg ctccaaaaat gctttcgcgt cgcgcagaca ctgctcggta gtttcgggga 600 tcagcgtttg agtaagagcc cgcgtctgaa ccctccgcgc cgccccggcc ccagtggaaa 660 gacgcgcagg caaaacgcac cacgtgacgg agcgtgaccg cgcgccgagc gcgcgccaag 720 gtcgggcagg aagagggcct atttcccatg attccttcat atttgcatat acgatacaag 780 gctgttagag agataattag aattaatttg actgtaaaca caaagatatt agtacaaaat 840 acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa 900 atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc 960 ttgtggaaag gacgaaacac cgcaccagag taacagtctg aggtttaaga gctatgctgg 1020 aaacagcata gcaagtttaa ataaggctag tccgttatca acttgaaaaa gtggcaccga 1080 gtcggtgctt tttttgcggc cgcgctcggc gcgcccatat ttgcatgtcg ctatgtgttc 1140 tgggaaatca ccataaacgt gaaatgtctt tggatttggg aatcttataa gttctgtatg 1200 agaccacggt acaccgcacc agagtaacag tctgaggttt aagagctatg ctggaaacag 1260 catagcaagt ttaaataagg ctagtccgtt atcaacttga aaaagtggca ccgagtcggt 1320 gctttttttg cggccgctga cggcgcgccc tgcagtattt agcatgcccc acccatctgc 1380 aaggcattct ggatagtgtc aaaacagccg gaaatcaagt ccgtttatct caaactttag 1440 cattttggga ataaatgata tttgctatgc tggttaaatt agattttagt taaatttcct 1500 gctgaagctc tagtacgata agtaacttga cctaagtgta aagttgagat ttccttcagg 1560 tttatatagc ttgtgcgccg cctgggtaca ccgcaccaga gtaacagtct gaggtttaag 1620 agctatgctg gaaacagcat agcaagttta aataaggcta gtccgttatc aacttgaaaa 1680 agtggcaccg agtcggtgct ttttttgcgg ccgcgctgtt taaaccaaca aaatcagcag 1740 ctaatgaagg caagtcagca ggtcactcat cattttccac ttcggcaatg cagtgggatt 1800 attccaacag aggtttttca cagcattcct tcagttaact ggagatcgaa tcttgatttt 1860 cacagatata cttggcaagg tccgccctgt catcagcaca ttcaagcaga tctccatggc 1920 agcattccgt gtggacttag gtaagatctg tcactaactt ggaaacttct gcaaactcag 1980 cttagggaaa tctctggctc aggcgagcta ctgcctcagc ttagaaagct ctttctccaa 2040 attattggag actggcacac ttaagtccct gttaggcaga cgaagccttc ccttcatccc 2100 gaagttcatc gagctttggc aacaggcagg cagctttatc agcagcttgg caacattctg 2160 taaaagcagc tttatacctt taagcaaaga aaaggagttc cggggcataa aagtaaggat 2220 gtcttctggc aatttataat aagtattttt tcaaaaatgt ctcttcattg tcatgaaaag 2280 cagtgcatca cacatcaacc tctggtctca ccaatcgggg gaggtttggg ttgtttactt 2340 agtgttgcaa gaattatttt attctctcag gttcttgttt tgcacagcag tcagctcatt 2400 caccataggt ttcacgaaga gttgctgcgg ccgcctcgat aatacgactc actatagggt 2460 cgacgatatc agatctagga acccctagtg atggagttgg ccactccctc tctgcgcgct 2520 cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg 2580 gcctcagtga gcgagcgagc gcgcagctgc ctgcaggcat gcaagctgta gccaaccact 2640 agaactatag ctagagtcct gggcgaacaa acgatgctcg ccttccagaa aaccgaggat 2700 gcgaaccact tcatccgggg tcagcaccac cggcaagcgc cgcgacggcc gaggtcttcc 2760 gatctcctga agccagggca gatccgtgca cagcaccttg ccgtagaaga acagcaaggc 2820 cgccaatgcc tgacgatgcg tggagaccga aaccttgcgc tcgttcgcca gccaggacag 2880 aaatgcctcg acttcgctgc tgcccaaggt tgccgggtga cgcacaccgt ggaaacggat 2940 gaaggcacga acccagttga cataagcctg ttcggttcgt aaactgtaat gcaagtagcg 3000 tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta acggcgcagt 3060 ggcggttttc atggcttgtt atgactgttt ttttgtacag tctatgcctc gggcatccaa 3120 gcagcaagcg cgttacgccg tgggtcgatg tttgatgtta tggagcagca acgatgttac 3180 gcagcagcaa cgatgttacg cagcagggca gtcgccctaa aacaaagtta ggtggctcaa 3240 gtatgggcat cattcgcaca tgtaggctcg gccctgacca agtcaaatcc atgcgggctg 3300 ctcttgatct tttcggtcgt gagttcggag acgtagccac ctactcccaa catcagccgg 3360 actccgatta cctcgggaac ttgctccgta gtaagacatt catcgcgctt gctgccttcg 3420 accaagaagc ggttgttggc gctctcgcgg cttacgttct gcccaagttt gagcagccgc 3480 gtagtgagat ctatatctat gatctcgcag tctccggcga gcaccggagg cagggcattg 3540 ccaccgcgct catcaatctc ctcaagcatg aggccaacgc gcttggtgct tatgtgatct 3600 acgtgcaagc agattacggt gacgatcccg cagtggctct ctatacaaag ttgggcatac 3660 gggaagaagt gatgcacttt gatatcgacc caagtaccgc cacctaacaa ttcgttcaag 3720 ccgagatcgg cttcccggcc gcggagttgt tcggtaaatt gtcacaacgc cgcgaatata 3780 gtctttacca tgcccttggc cacgcccctc tttaatacga cgggcaattt gcacttcaga 3840 aaatgaagag tttgctttag ccataacaaa agtccagtat gctttttcac agcataactg 3900 gactgatttc agtttacaac tattctgtct agtttaagac tttattgtca tagtttagat 3960 ctattttgtt cagtttaaga ctttattgtc cgcccacacc cgcttacgc 4009 <210> 917 <211> 4009 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 917 aagatgacgg tttgtcacat ggagttggca ggatgtttga ttaaaaacat aacaggaaga 60 aaaatgcccc gctgtgggcg gacaaaatag ttgggaactg ggaggggtgg aaatggagtt 120 tttaaggatt atttagggaa gagtgacaaa atagatggga actgggtgta gcgtcgtaag 180 ctaatacgaa aattaaaaat gacaaaatag tttggaacta gatttcactt atctggttcg 240 gatctcctag gcgatatcag tgatcacgga tctcgaccaa ttgacattat tgaagcaact 300 agtatcgatt ttatcagggt tattgtctca gaccactccc tctatgcgcg ctcgctcact 360 cactcggccc tggagaccaa aggtctccag actgccggcc tctggccggc agggccgagt 420 gagtgagcga gcgcgcatag agggagtggg tacctccatc atctaggttt gccagatctg 480 atatcggcgc gcccctgggc gcgcccgagt ccaacacccg tgggaatccc atgggcacca 540 tggcccctcg ctccaaaaat gctttcgcgt cgcgcagaca ctgctcggta gtttcgggga 600 tcagcgtttg agtaagagcc cgcgtctgaa ccctccgcgc cgccccggcc ccagtggaaa 660 gacgcgcagg caaaacgcac cacgtgacgg agcgtgaccg cgcgccgagc gcgcgccaag 720 gtcgggcagg aagagggcct atttcccatg attccttcat atttgcatat acgatacaag 780 gctgttagag agataattag aattaatttg actgtaaaca caaagatatt agtacaaaat 840 acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa 900 atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc 960 ttgtggaaag gacgaaacac cgcaccagag taacagtctg aggtttaaga gctatgctgg 1020 aaacagcata gcaagtttaa ataaggctag tccgttatca acttgaaaaa gtggcaccga 1080 gtcggtgctt tttttgcggc cgcgctcggc gcgcccatat ttgcatgtcg ctatgtgttc 1140 tgggaaatca ccataaacgt gaaatgtctt tggatttggg aatcttataa gttctgtatg 1200 agaccacggt acaccgcacc agagtaacag tctgaggttt aagagctatg ctggaaacag 1260 catagcaagt ttaaataagg ctagtccgtt atcaacttga aaaagtggca ccgagtcggt 1320 gctttttttg cggccgctga cggcgcgccc tgcagtattt agcatgcccc acccatctgc 1380 aaggcattct ggatagtgtc aaaacagccg gaaatcaagt ccgtttatct caaactttag 1440 cattttggga ataaatgata tttgctatgc tggttaaatt agattttagt taaatttcct 1500 gctgaagctc tagtacgata agtaacttga cctaagtgta aagttgagat ttccttcagg 1560 tttatatagc ttgtgcgccg cctgggtaca ccgcaccaga gtaacagtct gaggtttaag 1620 agctatgctg gaaacagcat agcaagttta aataaggcta gtccgttatc aacttgaaaa 1680 agtggcaccg agtcggtgct ttttttgcgg ccgcgctgtt taaaccaaca aaatcagcag 1740 ctaatgaagg caagtcagca ggtcactcat cattttccac ttcggcaatg cagtgggatt 1800 attccaacag aggtttttca cagcattcct tcagttaact ggagatcgaa tcttgatttt 1860 cacagatata cttggcaagg tccgccctgt catcagcaca ttcaagcaga tctccatggc 1920 agcattccgt gtggacttag gtaagatctg tcactaactt ggaaacttct gcaaactcag 1980 cttagggaaa tctctggctc aggcgagcta ctgcctcagc ttagaaagct ctttctccaa 2040 attattggag actggcacac ttaagtccct gttaggcaga cgaagccttc ccttcatccc 2100 gaagttcatc gagctttggc aacaggcagg cagctttatc agcagcttgg caacattctg 2160 taaaagcagc tttatacctt taagcaaaga aaaggagttc cggggcataa aagtaaggat 2220 gtcttctggc aatttataat aagtattttt tcaaaaatgt ctcttcattg tcatgaaaag 2280 cagtgcatca cacatcaacc tctggtctca ccaatcgggg gaggtttggg ttgtttactt 2340 agtgttgcaa gaattatttt attctctcag gttcttgttt tgcacagcag tcagctcatt 2400 caccataggt ttcacgaaga gttgctgcgg ccgcctcgat aatacgactc actatagggt 2460 cgacgatatc agatctagga acccctagtg atggagttgg ccactccctc tctgcgcgct 2520 cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg 2580 gcctcagtga gcgagcgagc gcgcagagag ggagtggcat gcaagctgta gccaaccact 2640 agaactatag ctagagtcct gggcgaacaa acgatgctcg ccttccagaa aaccgaggat 2700 gcgaaccact tcatccgggg tcagcaccac cggcaagcgc cgcgacggcc gaggtcttcc 2760 gatctcctga agccagggca gatccgtgca cagcaccttg ccgtagaaga acagcaaggc 2820 cgccaatgcc tgacgatgcg tggagaccga aaccttgcgc tcgttcgcca gccaggacag 2880 aaatgcctcg acttcgctgc tgcccaaggt tgccgggtga cgcacaccgt ggaaacggat 2940 gaaggcacga acccagttga cataagcctg ttcggttcgt aaactgtaat gcaagtagcg 3000 tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta acggcgcagt 3060 ggcggttttc atggcttgtt atgactgttt ttttgtacag tctatgcctc gggcatccaa 3120 gcagcaagcg cgttacgccg tgggtcgatg tttgatgtta tggagcagca acgatgttac 3180 gcagcagcaa cgatgttacg cagcagggca gtcgccctaa aacaaagtta ggtggctcaa 3240 gtatgggcat cattcgcaca tgtaggctcg gccctgacca agtcaaatcc atgcgggctg 3300 ctcttgatct tttcggtcgt gagttcggag acgtagccac ctactcccaa catcagccgg 3360 actccgatta cctcgggaac ttgctccgta gtaagacatt catcgcgctt gctgccttcg 3420 accaagaagc ggttgttggc gctctcgcgg cttacgttct gcccaagttt gagcagccgc 3480 gtagtgagat ctatatctat gatctcgcag tctccggcga gcaccggagg cagggcattg 3540 ccaccgcgct catcaatctc ctcaagcatg aggccaacgc gcttggtgct tatgtgatct 3600 acgtgcaagc agattacggt gacgatcccg cagtggctct ctatacaaag ttgggcatac 3660 gggaagaagt gatgcacttt gatatcgacc caagtaccgc cacctaacaa ttcgttcaag 3720 ccgagatcgg cttcccggcc gcggagttgt tcggtaaatt gtcacaacgc cgcgaatata 3780 gtctttacca tgcccttggc cacgcccctc tttaatacga cgggcaattt gcacttcaga 3840 aaatgaagag tttgctttag ccataacaaa agtccagtat gctttttcac agcataactg 3900 gactgatttc agtttacaac tattctgtct agtttaagac tttattgtca tagtttagat 3960 ctattttgtt cagtttaaga ctttattgtc cgcccacacc cgcttacgc 4009 <210> 918 <211> 2285 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 918 ccactccctc tatgcgcgct cgctcactca ctcggccctg gagaccaaag gtctccagac 60 tgccggcctc tggccggcag ggccgagtga gtgagcgagc gcgcatagag ggagtgggta 120 cctccatcat ctaggtttgc cagatctgat atcggcgcgc ccctgggcgc gcccgagtcc 180 aacacccgtg ggaatcccat gggcaccatg gcccctcgct ccaaaaatgc tttcgcgtcg 240 cgcagacact gctcggtagt ttcggggatc agcgtttgag taagagcccg cgtctgaacc 300 ctccgcgccg ccccggcccc agtggaaaga cgcgcaggca aaacgcacca cgtgacggag 360 cgtgaccgcg cgccgagcgc gcgccaaggt cgggcaggaa gagggcctat ttcccatgat 420 tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa ttaatttgac 480 tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta 540 gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa 600 gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacaccg caccagagta 660 acagtctgac gtttaagagc tatgctggaa acagcatagc aagtttaaat aaggctagtc 720 cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tttgcggccg cgctcggcgc 780 gcccatattt gcatgtcgct atgtgttctg ggaaatcacc ataaacgtga aatgtctttg 840 gatttgggaa tcttataagt tctgtatgag accacggtac accgcaccag agtaacagtc 900 tgacgtttaa gagctatgct ggaaacagca tagcaagttt aaataaggct agtccgttat 960 caacttgaaa aagtggcacc gagtcggtgc tttttttgcg gccgctgacg gcgcgccctg 1020 cagtatttag catgccccac ccatctgcaa ggcattctgg atagtgtcaa aacagccgga 1080 aatcaagtcc gtttatctca aactttagca ttttgggaat aaatgatatt tgctatgctg 1140 gttaaattag attttagtta aatttcctgc tgaagctcta gtacgataag taacttgacc 1200 taagtgtaaa gttgagattt ccttcaggtt tatatagctt gtgcgccgcc tgggtacacc 1260 gcaccagagt aacagtctga cgtttaagag ctatgctgga aacagcatag caagtttaaa 1320 taaggctagt ccgttatcaa cttgaaaaag tggcaccgag tcggtgcttt ttttgcggcc 1380 gcgctgttta aaccaacaaa atcagcagct aatgaaggca agtcagcagg tcactcatca 1440 ttttccactt cggcaatgca gtgggattat tccaacagag gtttttcaca gcattccttc 1500 agttaactgg agatcgaatc ttgattttca cagatatact tggcaaggtc cgccctgtca 1560 tcagcacatt caagcagatc tccatggcag cattccgtgt ggacttaggt aagatctgtc 1620 actaacttgg aaacttctgc aaactcagct tagggaaatc tctggctcag gcgagctact 1680 gcctcagctt agaaagctct ttctccaaat tattggagac tggcacactt aagtccctgt 1740 taggcagacg aagccttccc ttcatcccga agttcatcga gctttggcaa caggcaggca 1800 gctttatcag cagcttggca acattctgta aaagcagctt tataccttta agcaaagaaa 1860 aggagttccg gggcataaaa gtaaggatgt cttctggcaa tttataataa gtattttttc 1920 aaaaatgtct cttcattgtc atgaaaagca gtgcatcaca catcaacctc tggtctcacc 1980 aatcggggga ggtttgggtt gtttacttag tgttgcaaga attattttat tctctcaggt 2040 tcttgttttg cacagcagtc agctcattca ccataggttt cacgaagagt tgctgcggcc 2100 gcctcgataa tacgactcac tatagggtcg acgatatcag atctaggaac ccctagtgat 2160 ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgccc gggcaaagcc 2220 cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc gcagagaggg 2280 agtgg 2285 <210> 919 <211> 2285 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 919 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc tagatctgat atcggcgcgc ccctgggcgc gcccgagtcc 180 aacacccgtg ggaatcccat gggcaccatg gcccctcgct ccaaaaatgc tttcgcgtcg 240 cgcagacact gctcggtagt ttcggggatc agcgtttgag taagagcccg cgtctgaacc 300 ctccgcgccg ccccggcccc agtggaaaga cgcgcaggca aaacgcacca cgtgacggag 360 cgtgaccgcg cgccgagcgc gcgccaaggt cgggcaggaa gagggcctat ttcccatgat 420 tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa ttaatttgac 480 tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta 540 gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa 600 gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacaccg caccagagta 660 acagtctgac gtttaagagc tatgctggaa acagcatagc aagtttaaat aaggctagtc 720 cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt tttgcggccg cgctcggcgc 780 gcccatattt gcatgtcgct atgtgttctg ggaaatcacc ataaacgtga aatgtctttg 840 gatttgggaa tcttataagt tctgtatgag accacggtac accgcaccag agtaacagtc 900 tgacgtttaa gagctatgct ggaaacagca tagcaagttt aaataaggct agtccgttat 960 caacttgaaa aagtggcacc gagtcggtgc tttttttgcg gccgctgacg gcgcgccctg 1020 cagtatttag catgccccac ccatctgcaa ggcattctgg atagtgtcaa aacagccgga 1080 aatcaagtcc gtttatctca aactttagca ttttgggaat aaatgatatt tgctatgctg 1140 gttaaattag attttagtta aatttcctgc tgaagctcta gtacgataag taacttgacc 1200 taagtgtaaa gttgagattt ccttcaggtt tatatagctt gtgcgccgcc tgggtacacc 1260 gcaccagagt aacagtctga cgtttaagag ctatgctgga aacagcatag caagtttaaa 1320 taaggctagt ccgttatcaa cttgaaaaag tggcaccgag tcggtgcttt ttttgcggcc 1380 gcgctgttta aaccaacaaa atcagcagct aatgaaggca agtcagcagg tcactcatca 1440 ttttccactt cggcaatgca gtgggattat tccaacagag gtttttcaca gcattccttc 1500 agttaactgg agatcgaatc ttgattttca cagatatact tggcaaggtc cgccctgtca 1560 tcagcacatt caagcagatc tccatggcag cattccgtgt ggacttaggt aagatctgtc 1620 actaacttgg aaacttctgc aaactcagct tagggaaatc tctggctcag gcgagctact 1680 gcctcagctt agaaagctct ttctccaaat tattggagac tggcacactt aagtccctgt 1740 taggcagacg aagccttccc ttcatcccga agttcatcga gctttggcaa caggcaggca 1800 gctttatcag cagcttggca acattctgta aaagcagctt tataccttta agcaaagaaa 1860 aggagttccg gggcataaaa gtaaggatgt cttctggcaa tttataataa gtattttttc 1920 aaaaatgtct cttcattgtc atgaaaagca gtgcatcaca catcaacctc tggtctcacc 1980 aatcggggga ggtttgggtt gtttacttag tgttgcaaga attattttat tctctcaggt 2040 tcttgttttg cacagcagtc agctcattca ccataggttt cacgaagagt tgctgcggcc 2100 gcctcgataa tacgactcac tatagggtcg acgatatcag atctaggaac ccctagtgat 2160 ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt 2220 cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct 2280 gcagg 2285 <210> 920 <211> 4009 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 920 aagatgacgg tttgtcacat ggagttggca ggatgtttga ttaaaaacat aacaggaaga 60 aaaatgcccc gctgtgggcg gacaaaatag ttgggaactg ggaggggtgg aaatggagtt 120 tttaaggatt atttagggaa gagtgacaaa atagatggga actgggtgta gcgtcgtaag 180 ctaatacgaa aattaaaaat gacaaaatag tttggaacta gatttcactt atctggttcg 240 gatctcctag gcgatatcag tgatcacgga tctcgaccaa ttgacattat tgaagcaact 300 agtatcgatt ttatcagggt tattgtctca gacctgcagg cagctgcgcg ctcgctcgct 360 cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt 420 gagcgagcga gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg 480 atatcggcgc gcccctgggc gcgcccgagt ccaacacccg tgggaatccc atgggcacca 540 tggcccctcg ctccaaaaat gctttcgcgt cgcgcagaca ctgctcggta gtttcgggga 600 tcagcgtttg agtaagagcc cgcgtctgaa ccctccgcgc cgccccggcc ccagtggaaa 660 gacgcgcagg caaaacgcac cacgtgacgg agcgtgaccg cgcgccgagc gcgcgccaag 720 gtcgggcagg aagagggcct atttcccatg attccttcat atttgcatat acgatacaag 780 gctgttagag agataattag aattaatttg actgtaaaca caaagatatt agtacaaaat 840 acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa 900 atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc 960 ttgtggaaag gacgaaacac cgcaccagag taacagtctg acgtttaaga gctatgctgg 1020 aaacagcata gcaagtttaa ataaggctag tccgttatca acttgaaaaa gtggcaccga 1080 gtcggtgctt tttttgcggc cgcgctcggc gcgcccatat ttgcatgtcg ctatgtgttc 1140 tgggaaatca ccataaacgt gaaatgtctt tggatttggg aatcttataa gttctgtatg 1200 agaccacggt acaccgcacc agagtaacag tctgacgttt aagagctatg ctggaaacag 1260 catagcaagt ttaaataagg ctagtccgtt atcaacttga aaaagtggca ccgagtcggt 1320 gctttttttg cggccgctga cggcgcgccc tgcagtattt agcatgcccc acccatctgc 1380 aaggcattct ggatagtgtc aaaacagccg gaaatcaagt ccgtttatct caaactttag 1440 cattttggga ataaatgata tttgctatgc tggttaaatt agattttagt taaatttcct 1500 gctgaagctc tagtacgata agtaacttga cctaagtgta aagttgagat ttccttcagg 1560 tttatatagc ttgtgcgccg cctgggtaca ccgcaccaga gtaacagtct gacgtttaag 1620 agctatgctg gaaacagcat agcaagttta aataaggcta gtccgttatc aacttgaaaa 1680 agtggcaccg agtcggtgct ttttttgcgg ccgcgctgtt taaaccaaca aaatcagcag 1740 ctaatgaagg caagtcagca ggtcactcat cattttccac ttcggcaatg cagtgggatt 1800 attccaacag aggtttttca cagcattcct tcagttaact ggagatcgaa tcttgatttt 1860 cacagatata cttggcaagg tccgccctgt catcagcaca ttcaagcaga tctccatggc 1920 agcattccgt gtggacttag gtaagatctg tcactaactt ggaaacttct gcaaactcag 1980 cttagggaaa tctctggctc aggcgagcta ctgcctcagc ttagaaagct ctttctccaa 2040 attattggag actggcacac ttaagtccct gttaggcaga cgaagccttc ccttcatccc 2100 gaagttcatc gagctttggc aacaggcagg cagctttatc agcagcttgg caacattctg 2160 taaaagcagc tttatacctt taagcaaaga aaaggagttc cggggcataa aagtaaggat 2220 gtcttctggc aatttataat aagtattttt tcaaaaatgt ctcttcattg tcatgaaaag 2280 cagtgcatca cacatcaacc tctggtctca ccaatcgggg gaggtttggg ttgtttactt 2340 agtgttgcaa gaattatttt attctctcag gttcttgttt tgcacagcag tcagctcatt 2400 caccataggt ttcacgaaga gttgctgcgg ccgcctcgat aatacgactc actatagggt 2460 cgacgatatc agatctagga acccctagtg atggagttgg ccactccctc tctgcgcgct 2520 cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg 2580 gcctcagtga gcgagcgagc gcgcagctgc ctgcaggcat gcaagctgta gccaaccact 2640 agaactatag ctagagtcct gggcgaacaa acgatgctcg ccttccagaa aaccgaggat 2700 gcgaaccact tcatccgggg tcagcaccac cggcaagcgc cgcgacggcc gaggtcttcc 2760 gatctcctga agccagggca gatccgtgca cagcaccttg ccgtagaaga acagcaaggc 2820 cgccaatgcc tgacgatgcg tggagaccga aaccttgcgc tcgttcgcca gccaggacag 2880 aaatgcctcg acttcgctgc tgcccaaggt tgccgggtga cgcacaccgt ggaaacggat 2940 gaaggcacga acccagttga cataagcctg ttcggttcgt aaactgtaat gcaagtagcg 3000 tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta acggcgcagt 3060 ggcggttttc atggcttgtt atgactgttt ttttgtacag tctatgcctc gggcatccaa 3120 gcagcaagcg cgttacgccg tgggtcgatg tttgatgtta tggagcagca acgatgttac 3180 gcagcagcaa cgatgttacg cagcagggca gtcgccctaa aacaaagtta ggtggctcaa 3240 gtatgggcat cattcgcaca tgtaggctcg gccctgacca agtcaaatcc atgcgggctg 3300 ctcttgatct tttcggtcgt gagttcggag acgtagccac ctactcccaa catcagccgg 3360 actccgatta cctcgggaac ttgctccgta gtaagacatt catcgcgctt gctgccttcg 3420 accaagaagc ggttgttggc gctctcgcgg cttacgttct gcccaagttt gagcagccgc 3480 gtagtgagat ctatatctat gatctcgcag tctccggcga gcaccggagg cagggcattg 3540 ccaccgcgct catcaatctc ctcaagcatg aggccaacgc gcttggtgct tatgtgatct 3600 acgtgcaagc agattacggt gacgatcccg cagtggctct ctatacaaag ttgggcatac 3660 gggaagaagt gatgcacttt gatatcgacc caagtaccgc cacctaacaa ttcgttcaag 3720 ccgagatcgg cttcccggcc gcggagttgt tcggtaaatt gtcacaacgc cgcgaatata 3780 gtctttacca tgcccttggc cacgcccctc tttaatacga cgggcaattt gcacttcaga 3840 aaatgaagag tttgctttag ccataacaaa agtccagtat gctttttcac agcataactg 3900 gactgatttc agtttacaac tattctgtct agtttaagac tttattgtca tagtttagat 3960 ctattttgtt cagtttaaga ctttattgtc cgcccacacc cgcttacgc 4009 <210> 921 <211> 4009 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 921 aagatgacgg tttgtcacat ggagttggca ggatgtttga ttaaaaacat aacaggaaga 60 aaaatgcccc gctgtgggcg gacaaaatag ttgggaactg ggaggggtgg aaatggagtt 120 tttaaggatt atttagggaa gagtgacaaa atagatggga actgggtgta gcgtcgtaag 180 ctaatacgaa aattaaaaat gacaaaatag tttggaacta gatttcactt atctggttcg 240 gatctcctag gcgatatcag tgatcacgga tctcgaccaa ttgacattat tgaagcaact 300 agtatcgatt ttatcagggt tattgtctca gaccactccc tctatgcgcg ctcgctcact 360 cactcggccc tggagaccaa aggtctccag actgccggcc tctggccggc agggccgagt 420 gagtgagcga gcgcgcatag agggagtggg tacctccatc atctaggttt gccagatctg 480 atatcggcgc gcccctgggc gcgcccgagt ccaacacccg tgggaatccc atgggcacca 540 tggcccctcg ctccaaaaat gctttcgcgt cgcgcagaca ctgctcggta gtttcgggga 600 tcagcgtttg agtaagagcc cgcgtctgaa ccctccgcgc cgccccggcc ccagtggaaa 660 gacgcgcagg caaaacgcac cacgtgacgg agcgtgaccg cgcgccgagc gcgcgccaag 720 gtcgggcagg aagagggcct atttcccatg attccttcat atttgcatat acgatacaag 780 gctgttagag agataattag aattaatttg actgtaaaca caaagatatt agtacaaaat 840 acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa 900 atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc 960 ttgtggaaag gacgaaacac cgcaccagag taacagtctg acgtttaaga gctatgctgg 1020 aaacagcata gcaagtttaa ataaggctag tccgttatca acttgaaaaa gtggcaccga 1080 gtcggtgctt tttttgcggc cgcgctcggc gcgcccatat ttgcatgtcg ctatgtgttc 1140 tgggaaatca ccataaacgt gaaatgtctt tggatttggg aatcttataa gttctgtatg 1200 agaccacggt acaccgcacc agagtaacag tctgacgttt aagagctatg ctggaaacag 1260 catagcaagt ttaaataagg ctagtccgtt atcaacttga aaaagtggca ccgagtcggt 1320 gctttttttg cggccgctga cggcgcgccc tgcagtattt agcatgcccc acccatctgc 1380 aaggcattct ggatagtgtc aaaacagccg gaaatcaagt ccgtttatct caaactttag 1440 cattttggga ataaatgata tttgctatgc tggttaaatt agattttagt taaatttcct 1500 gctgaagctc tagtacgata agtaacttga cctaagtgta aagttgagat ttccttcagg 1560 tttatatagc ttgtgcgccg cctgggtaca ccgcaccaga gtaacagtct gacgtttaag 1620 agctatgctg gaaacagcat agcaagttta aataaggcta gtccgttatc aacttgaaaa 1680 agtggcaccg agtcggtgct ttttttgcgg ccgcgctgtt taaaccaaca aaatcagcag 1740 ctaatgaagg caagtcagca ggtcactcat cattttccac ttcggcaatg cagtgggatt 1800 attccaacag aggtttttca cagcattcct tcagttaact ggagatcgaa tcttgatttt 1860 cacagatata cttggcaagg tccgccctgt catcagcaca ttcaagcaga tctccatggc 1920 agcattccgt gtggacttag gtaagatctg tcactaactt ggaaacttct gcaaactcag 1980 cttagggaaa tctctggctc aggcgagcta ctgcctcagc ttagaaagct ctttctccaa 2040 attattggag actggcacac ttaagtccct gttaggcaga cgaagccttc ccttcatccc 2100 gaagttcatc gagctttggc aacaggcagg cagctttatc agcagcttgg caacattctg 2160 taaaagcagc tttatacctt taagcaaaga aaaggagttc cggggcataa aagtaaggat 2220 gtcttctggc aatttataat aagtattttt tcaaaaatgt ctcttcattg tcatgaaaag 2280 cagtgcatca cacatcaacc tctggtctca ccaatcgggg gaggtttggg ttgtttactt 2340 agtgttgcaa gaattatttt attctctcag gttcttgttt tgcacagcag tcagctcatt 2400 caccataggt ttcacgaaga gttgctgcgg ccgcctcgat aatacgactc actatagggt 2460 cgacgatatc agatctagga acccctagtg atggagttgg ccactccctc tctgcgcgct 2520 cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg 2580 gcctcagtga gcgagcgagc gcgcagagag ggagtggcat gcaagctgta gccaaccact 2640 agaactatag ctagagtcct gggcgaacaa acgatgctcg ccttccagaa aaccgaggat 2700 gcgaaccact tcatccgggg tcagcaccac cggcaagcgc cgcgacggcc gaggtcttcc 2760 gatctcctga agccagggca gatccgtgca cagcaccttg ccgtagaaga acagcaaggc 2820 cgccaatgcc tgacgatgcg tggagaccga aaccttgcgc tcgttcgcca gccaggacag 2880 aaatgcctcg acttcgctgc tgcccaaggt tgccgggtga cgcacaccgt ggaaacggat 2940 gaaggcacga acccagttga cataagcctg ttcggttcgt aaactgtaat gcaagtagcg 3000 tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta acggcgcagt 3060 ggcggttttc atggcttgtt atgactgttt ttttgtacag tctatgcctc gggcatccaa 3120 gcagcaagcg cgttacgccg tgggtcgatg tttgatgtta tggagcagca acgatgttac 3180 gcagcagcaa cgatgttacg cagcagggca gtcgccctaa aacaaagtta ggtggctcaa 3240 gtatgggcat cattcgcaca tgtaggctcg gccctgacca agtcaaatcc atgcgggctg 3300 ctcttgatct tttcggtcgt gagttcggag acgtagccac ctactcccaa catcagccgg 3360 actccgatta cctcgggaac ttgctccgta gtaagacatt catcgcgctt gctgccttcg 3420 accaagaagc ggttgttggc gctctcgcgg cttacgttct gcccaagttt gagcagccgc 3480 gtagtgagat ctatatctat gatctcgcag tctccggcga gcaccggagg cagggcattg 3540 ccaccgcgct catcaatctc ctcaagcatg aggccaacgc gcttggtgct tatgtgatct 3600 acgtgcaagc agattacggt gacgatcccg cagtggctct ctatacaaag ttgggcatac 3660 gggaagaagt gatgcacttt gatatcgacc caagtaccgc cacctaacaa ttcgttcaag 3720 ccgagatcgg cttcccggcc gcggagttgt tcggtaaatt gtcacaacgc cgcgaatata 3780 gtctttacca tgcccttggc cacgcccctc tttaatacga cgggcaattt gcacttcaga 3840 aaatgaagag tttgctttag ccataacaaa agtccagtat gctttttcac agcataactg 3900 gactgatttc agtttacaac tattctgtct agtttaagac tttattgtca tagtttagat 3960 ctattttgtt cagtttaaga ctttattgtc cgcccacacc cgcttacgc 4009 <210> 922 <211> 472 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 922 cgagtccaac acccgtggga atcccatggg caccatggcc cctcgctcca aaaatgcttt 60 cgcgtcgcgc agacactgct cggtagtttc ggggatcagc gtttgagtaa gagcccgcgt 120 ctgaaccctc cgcgccgccc cggccccagt ggaaagacgc gcaggcaaaa cgcaccacgt 180 gacggagcgt gaccgcgcgc cgagcgcgcg ccaaggtcgg gcaggaagag ggcctatttc 240 ccatgattcc ttcatatttg catatacgat acaaggctgt tagagagata attagaatta 300 atttgactgt aaacacaaag atattagtac aaaatacgtg acgtagaaag taataatttc 360 ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga ctatcatatg cttaccgtaa 420 cttgaaagta tttcgatttc ttggctttat atatcttgtg gaaaggacga aa 472 <210> 923 <211> 108 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 923 gctcggcgcg cccatatttg catgtcgcta tgtgttctgg gaaatcacca taaacgtgaa 60 atgtctttgg atttgggaat cttataagtt ctgtatgaga ccacggta 108 <210> 924 <211> 251 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 924 tgacggcgcg ccctgcagta tttagcatgc cccacccatc tgcaaggcat tctggatagt 60 gtcaaaacag ccggaaatca agtccgttta tctcaaactt tagcattttg ggaataaatg 120 atatttgcta tgctggttaa attagatttt agttaaattt cctgctgaag ctctagtacg 180 ataagtaact tgacctaagt gtaaagttga gatttccttc aggtttatat agcttgtgcg 240 ccgcctgggt a 251 <210> 925 <211> 251 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 925 tgacggcgcg ccctgcagta tttagcatgc cccacccatc tgcaaggcat tctggatagt 60 gtcaaaacag ccggaaatca agtccgttta tctcaaactt tagcattttg ggaataaatg 120 atatttgcta tgctggttaa attagatttt agttaaattt cctgctgaag ctctagtacg 180 ataagtaact tgacctaagt gtaaagttga gatttccttc aggtttatat agcttgtgcg 240 ccgcctgggt a 251 <210> 926 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 926 caccgaaatg atgagtgaag ttatat 26 <210> 927 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 927 aaacatataa cttcactcat catttc 26 <210> 928 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 928 caccggtttg ttcaaaagcg tggct 25 <210> 929 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 929 aaacagccac gcttttgaac aaac 24 <210> 930 <211> 45 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 930 gaattgtaat acgactcact ataggaatga tgagtgaagt tatat 45 <210> 931 <211> 45 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 931 gaattgtaat acgactcact atagggtttg ttcaaaagcg tggct 45 <210> 932 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 932 aaaagcaccg actcggtgcc ac 22 <210> 933 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 933 caccggacac aatgtaggaa gcct 24 <210> 934 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 934 aaacaggctt cctacattgt gtcc 24 <210> 935 <211> 40 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 935 gaattgtaat acgactcact ggacacaatg taggaagcct 40 <210> 936 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 936 aaaagcaccg actcggtgcc ac 22 <210> 937 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 937 ggattgactg aaatgatggc caagg 25 <210> 938 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 938 ctgccacgat tactctgctt ccag 24 <210> 939 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 939 agcaggcaga gaaggtggta 20 <210> 940 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 940 gggcgtatct cttcatagcc tt 22 <210> 941 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 941 gcgtgtgtgt ttgtttaggg 20 <210> 942 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 942 caccgagagt aacagtctga ctgg 24 <210> 943 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 943 aaacgtcaga ctgttactct agtgc 25 <210> 944 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 944 caccgcacta gagtaacagt ctgac 25 <210> 945 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 945 aaacccagtc agactgttac tctc 24 <210> 946 <211> 141 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 946 aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg 60 ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc 120 gagcgcgcag agagggagtg g 141 <210> 947 <211> 20 <212> DNA <213> Homo sapiens <400> 947 cagagtaaca gtctgagtag 20 <210> 948 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 948 cgctgcccaa tgccatcctg 20 <210> 949 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 949 atcttacagg aactccagga 20 <210> 950 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 950 aggaactcca ggatggcatt 20 <210> 951 <211> 18 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 951 cgctgcccaa tgccatcc 18 <210> 952 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 952 gttttaaaat ttttatatta 20 <210> 953 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 953 ttttatatta cagaatataa 20 <210> 954 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 954 tatgtgttac ctacccttgt 20 <210> 955 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 955 gtacaaggac cgacaagggt 20 <210> 956 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 956 caggauggca uugggcagcg 20 <210> 957 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 957 uccuggaguu ccuguaagau 20 <210> 958 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 958 aaugccaucc uggaguuccu 20 <210> 959 <211> 18 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 959 ggauggcauu gggcagcg 18 <210> 960 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 960 uaauauaaaa auuuuaaaac 20 <210> 961 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 961 uuauauucug uaauauaaaa 20 <210> 962 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 962 acaaggguag guaacacaua 20 <210> 963 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 963 acccuugucg guccuuguac 20 <210> 964 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 964 cgcugcccaa ugccauccug 20 <210> 965 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 965 aucuuacagg aacuccagga 20 <210> 966 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 966 aggaacucca ggauggcauu 20 <210> 967 <211> 18 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 967 cgcugcccaa ugccaucc 18 <210> 968 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 968 guuuuaaaau uuuuauauua 20 <210> 969 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 969 uuuuauauua cagaauauaa 20 <210> 970 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 970 uauguguuac cuacccuugu 20 <210> 971 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 971 guacaaggac cgacaagggu 20 <210> 972 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 972 tctttttctt cttttttcct tttt 24 <210> 973 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 973 ctttttcttc ttttttcctt tttg 24 <210> 974 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 974 tttttcttct tttttccttt ttgc 24 <210> 975 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 975 tcttcttttt tcctttttgc aaaa 24 <210> 976 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 976 cttctttttt cctttttgca aaaa 24 <210> 977 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 977 ttcttttttc ctttttgcaa aaac 24 <210> 978 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 978 ttcctttttg caaaaaccca aaat 24 <210> 979 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 979 tcctttttgc aaaaacccaa aata 24 <210> 980 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 980 cctttttgca aaaacccaaa atat 24 <210> 981 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 981 ctttttgcaa aaacccaaaa tatt 24 <210> 982 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 982 tgcaaaaacc caaaatattt tagc 24 <210> 983 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 983 gcaaaaaccc aaaatatttt agct 24 <210> 984 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 984 caaaaaccca aaatatttta gctc 24 <210> 985 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 985 agctcctact cagactgtta ctct 24 <210> 986 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 986 gctcctactc agactgttac tctg 24 <210> 987 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 987 cttagtaacc acaggttgtg tcac 24 <210> 988 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 988 gagatggcag tttccttagt aacc 24 <210> 989 <400> 989 000 <210> 990 <400> 990 000 <210> 991 <400> 991 000 <210> 992 <400> 992 000 <210> 993 <400> 993 000 <210> 994 <400> 994 000 <210> 995 <400> 995 000 <210> 996 <400> 996 000 <210> 997 <400> 997 000 <210> 998 <400> 998 000 <210> 999 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 999 tagtttggag atggcagttt cctt 24 <210> 1000 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1000 ttctcatacc ttctgcttga tgat 24 <210> 1001 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1001 tcattttttc tcataccttc tgct 24 <210> 1002 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1002 atcatttttt ctcatacctt ctgc 24 <210> 1003 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1003 aagaaaaact tctgccaact ttta 24 <210> 1004 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1004 aaagaaaaac ttctgccaac tttt 24 <210> 1005 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1005 tctttaaaat gaagattttc cacc 24 <210> 1006 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1006 ctttaaaatg aagattttcc acca 24 <210> 1007 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1007 tttaaaatga agattttcca ccaa 24 <210> 1008 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1008 aaatgaagat tttccaccaa tcac 24 <210> 1009 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1009 ccaccaatca ctttactctc ctag 24 <210> 1010 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1010 caccaatcac tttactctcc taga 24 <210> 1011 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1011 ctctcctaga ccatttccca ccag 24 <210> 1012 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1012 agaaaagatt aaacagtgtg ctac 24 <210> 1013 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1013 tttgagaaaa gattaaacag tgtg 24 <210> 1014 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1014 atttgagaaa agattaaaca gtgt 24 <210> 1015 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1015 tatttgagaa aagattaaac agtg 24 <210> 1016 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1016 atcttttctc aaataaaaag acat 24 <210> 1017 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1017 ctcaaataaa aagacatggg gctt 24 <210> 1018 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1018 tcaaataaaa agacatgggg cttc 24 <210> 1019 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1019 tgttttgcct ttttggtatc ttac 24 <210> 1020 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1020 gttttgcctt tttggtatct taca 24 <210> 1021 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1021 ttttgccttt ttggtatctt acag 24 <210> 1022 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1022 gcctttttgg tatcttacag gaac 24 <210> 1023 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1023 cctttttggt atcttacagg aact 24 <210> 1024 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1024 tggtatctta caggaactcc agga 24 <210> 1025 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1025 ggtatcttac aggaactcca ggat 24 <210> 1026 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1026 aggattgctg aattatttct tccc 24 <210> 1027 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1027 gaggattgct gaattatttc ttcc 24 <210> 1028 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1028 tgaggattgc tgaattattt cttc 24 <210> 1029 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1029 ctgtagaata ctggcatctg tttt 24 <210> 1030 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1030 cctgtagaat actggcatct gttt 24 <210> 1031 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1031 tcctgtagaa tactggcatc tgtt 24 <210> 1032 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1032 cagacctcct gccaccgcag attc 24 <210> 1033 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1033 tgtctgacag ctgtttgcag acct 24 <210> 1034 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1034 ctgtctgaca gctgtttgca gacc 24 <210> 1035 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1035 tctgtctgac agctgtttgc agac 24 <210> 1036 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1036 ttctgtctga cagctgtttg caga 24 <210> 1037 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1037 attcctatta gatctgtcgc ccta 24 <210> 1038 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1038 cattcctatt agatctgtcg ccct 24 <210> 1039 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1039 agcagacttt ttaagctttc ttta 24 <210> 1040 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1040 gcagactttt taagctttct ttag 24 <210> 1041 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1041 taagctttct ttagaagaat attt 24 <210> 1042 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1042 aagctttctt tagaagaata tttc 24 <210> 1043 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1043 agctttcttt agaagaatat ttca 24 <210> 1044 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1044 tttagaagaa tatttcatga gaga 24 <210> 1045 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1045 gaagaatatt tcatgagaga ttat 24 <210> 1046 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1046 tcagtataac caaaaaatat acgc 24 <210> 1047 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1047 acataatcca tctatttttc ttga 24 <210> 1048 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1048 cataatccat ctatttttct tgat 24 <210> 1049 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1049 tcttgatcca tatgctttta cctg 24 <210> 1050 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1050 cttgatccat atgcttttac ctgc 24 <210> 1051 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1051 ttgatccata tgcttttacc tgca 24 <210> 1052 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1052 tcaacagatc tgtcaaatcg cctg 24 <210> 1053 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1053 acctgcaggc gatttgacag atct 24 <210> 1054 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1054 cctgcaggcg atttgacaga tctg 24 <210> 1055 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1055 acagatctgt tgagaaatgg cggc 24 <210> 1056 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1056 tatcataatg aaaacgccgc catt 24 <210> 1057 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1057 cattatgata taaagatatt taat 24 <210> 1058 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1058 tatttagcat gttcccaatt ctca 24 <210> 1059 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1059 gaaaaaacaa atcaaagact tacc 24 <210> 1060 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1060 atttgttttt tcgaaattgt attt 24 <210> 1061 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1061 ttttttcgaa attgtattta tctt 24 <210> 1062 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1062 ttcgaaattg tatttatctt cagc 24 <210> 1063 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1063 tcgaaattgt atttatcttc agca 24 <210> 1064 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1064 cgaaattgta tttatcttca gcac 24 <210> 1065 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1065 gaaattgtat ttatcttcag caca 24 <210> 1066 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1066 agaagttaaa gagtccagat gtgc 24 <210> 1067 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1067 tcttcagcac atctggactc ttta 24 <210> 1068 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1068 catcaccctt cagaacctga tctt 24 <210> 1069 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1069 acttcttaaa gatcaggttc tgaa 24 <210> 1070 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1070 gactgttgtt gtcatcatta tatt 24 <210> 1071 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1071 actgttgttg tcatcattat atta 24 <210> 1072 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1072 aactagaata aaaggaaaaa taaa 24 <210> 1073 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1073 ctactatata tttatttttc cttt 24 <210> 1074 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1074 tttttccttt tattctagtt gaaa 24 <210> 1075 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1075 tccttttatt ctagttgaaa gaat 24 <210> 1076 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1076 ccttttattc tagttgaaag aatt 24 <210> 1077 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1077 cttttattct agttgaaaga attc 24 <210> 1078 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1078 attctagttg aaagaattca gaat 24 <210> 1079 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1079 ttctagttga aagaattcag aatc 24 <210> 1080 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1080 attcaactgt tgcctccggt tctg 24 <210> 1081 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1081 acatttcatt caactgttgc ctcc 24 <210> 1082 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1082 cttttggatt gcatctactg tata 24 <210> 1083 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1083 tgtgattttc ttttggattg catc 24 <210> 1084 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1084 atactaacct tggtttctgt gatt 24 <210> 1085 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1085 aaaaggtatc tttgatacta acct 24 <210> 1086 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1086 aaaaaggtat ctttgatact aacc 24 <210> 1087 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1087 ttttaaaaag gtatctttga tact 24 <210> 1088 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1088 attttaaaaa ggtatctttg atac 24 <210> 1089 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1089 ttaatgcaaa ctgggacaca aaca 24 <210> 1090 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1090 taaattgcca tgtttgtgtc ccag 24 <210> 1091 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1091 aaattgccat gtttgtgtcc cagt 24 <210> 1092 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1092 aattgccatg tttgtgtccc agtt 24 <210> 1093 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1093 tgtcccagtt tgcattaaca aata 24 <210> 1094 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1094 caacatagtt ctcaaactat ttgt 24 <210> 1095 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1095 ccaacatagt tctcaaacta tttg 24 <210> 1096 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1096 tccaacatag ttctcaaact attt 24 <210> 1097 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1097 tttccaacat agttctcaaa ctat 24 <210> 1098 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1098 ttttccaaca tagttctcaa acta 24 <210> 1099 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1099 tttttccaac atagttctca aact 24 <210> 1100 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1100 cattaacaaa tagtttgaga acta 24 <210> 1101 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1101 agaactatgt tggaaaaaaa aata 24 <210> 1102 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1102 gttcttctag cctggagaaa gaag 24 <210> 1103 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1103 attcttcttt ctccaggcta gaag 24 <210> 1104 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1104 ttcttctttc tccaggctag aaga 24 <210> 1105 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1105 tccaggctag aagaacaaaa gaat 24 <210> 1106 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1106 aaattctgac aagatattct tttg 24 <210> 1107 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1107 cttttagttg ctgctctttt ccag 24 <210> 1108 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1108 agaaaataaa attaccttga cttg 24 <210> 1109 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1109 tgcaagcagg ccctggggga tttg 24 <210> 1110 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1110 attttctcaa atcccccagg gcct 24 <210> 1111 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1111 ttttctcaaa tcccccaggg cctg 24 <210> 1112 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1112 ctcaaatccc ccagggcctg cttg 24 <210> 1113 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1113 tcaaatcccc cagggcctgc ttgc 24 <210> 1114 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1114 ttaattcaat cattggtttt ctgc 24 <210> 1115 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1115 taattcaatc attggttttc tgcc 24 <210> 1116 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1116 aattcaatca ttggttttct gccc 24 <210> 1117 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1117 attcaatcat tggttttctg ccca 24 <210> 1118 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1118 gcaaggaact atgaataacc taat 24 <210> 1119 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1119 ctgcccatta ggttattcat agtt 24 <210> 1120 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1120 tgcccattag gttattcata gttc 24 <210> 1121 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1121 tagaaaacaa tttaacagga aata 24 <210> 1122 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1122 ctgttaaatt gttttctata aacc 24 <210> 1123 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1123 gaaataaaaa agatgttact gtat 24 <210> 1124 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1124 agaaataaaa aagatgttac tgta 24 <210> 1125 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1125 ctataaaccc ttatacagta acat 24 <210> 1126 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1126 tataaaccct tatacagtaa catc 24 <210> 1127 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1127 ttatttctaa aagtgttttg gctg 24 <210> 1128 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1128 tatttctaaa agtgttttgg ctgg 24 <210> 1129 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1129 atttctaaaa gtgttttggc tggt 24 <210> 1130 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1130 tttctaaaag tgttttggct ggtc 24 <210> 1131 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1131 taaaagtgtt ttggctggtc tcac 24 <210> 1132 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1132 cataatacaa agtaaagtac aatt 24 <210> 1133 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1133 acataataca aagtaaagta caat 24 <210> 1134 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1134 ggctggtctc acaattgtac ttta 24 <210> 1135 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1135 gctggtctca caattgtact ttac 24 <210> 1136 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1136 ctttgtatta tgtaaaagga atac 24 <210> 1137 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1137 tattatgtaa aaggaataca caac 24 <210> 1138 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1138 ttcttacagg caacaatgca ggat 24 <210> 1139 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1139 gaacagaggc gtccccagtt ggaa 24 <210> 1140 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1140 ggcagcggta atgagttctt ccaa 24 <210> 1141 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1141 tcaaattttg ggcagcggta atga 24 <210> 1142 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1142 aaaaacaaga ccagcaatca agag 24 <210> 1143 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1143 tgtgtcccat gcttgttaaa aaac 24 <210> 1144 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1144 ttaacaagca tgggacacac aaag 24 <210> 1145 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1145 taacaagcat gggacacaca aagc 24 <210> 1146 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1146 aacaagcatg ggacacacaa agca 24 <210> 1147 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1147 acaagcatgg gacacacaaa gcaa 24 <210> 1148 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1148 ttgaaacttg tcatgcatct tgct 24 <210> 1149 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1149 attgaaactt gtcatgcatc ttgc 24 <210> 1150 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1150 tattgaaact tgtcatgcat cttg 24 <210> 1151 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1151 aataaaaact taagttcata tatc 24 <210> 1152 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1152 gtgaatatat tattggattt ctat 24 <210> 1153 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1153 aagataattc atgaacatct taat 24 <210> 1154 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1154 acagaaaagc atacacatta ctta 24 <210> 1155 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1155 ctgttaaaga ggaagttaga agat 24 <210> 1156 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1156 tgttaaagag gaagttagaa gatc 24 <210> 1157 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1157 ccgccttcca ctcagagctc agat 24 <210> 1158 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1158 ccctcagctc ttgaagtaaa cggt 24 <210> 1159 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1159 cttcaagagc tgagggcaaa gcag 24 <210> 1160 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1160 aacaaatagc tagagccaaa gaga 24 <210> 1161 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1161 gaacaaatag ctagagccaa agag 24 <210> 1162 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1162 gctctagcta tttgttcaaa agtg 24 <210> 1163 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1163 ttcaaaagtg caactatgaa gtga 24 <210> 1164 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1164 tctctcaccc agtcatcact tcat 24 <210> 1165 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1165 ctctctcacc cagtcatcac ttca 24 <210> 1166 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1166 tatatatata tatatttttc tctt 24 <210> 1167 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1167 tctctttcta tagacagcta attc 24 <210> 1168 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1168 ctctttctat agacagctaa ttca 24 <210> 1169 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1169 aaacagtaaa aaaatgaatt agct 24 <210> 1170 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1170 tctttctata gacagctaat tcat 24 <210> 1171 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1171 aaaacagtaa aaaaatgaat tagc 24 <210> 1172 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1172 tatagacagc taattcattt tttt 24 <210> 1173 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1173 tattctgtaa tataaaaatt ttaa 24 <210> 1174 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1174 atattctgta atataaaaat ttta 24 <210> 1175 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1175 tttactgttt taaaattttt atat 24 <210> 1176 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1176 ttactgtttt aaaattttta tatt 24 <210> 1177 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1177 tactgtttta aaatttttat atta 24 <210> 1178 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1178 actgttttaa aatttttata ttac 24 <210> 1179 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1179 ctgttttaaa atttttatat taca 24 <210> 1180 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1180 aaaattttta tattacagaa tata 24 <210> 1181 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1181 aaatttttat attacagaat ataa 24 <210> 1182 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1182 ttgtagacta tcttttatat tctg 24 <210> 1183 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1183 tatattacag aatataaaag atag 24 <210> 1184 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1184 atattacaga atataaaaga tagt 24 <210> 1185 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1185 tattacagaa tataaaagat agtc 24 <210> 1186 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1186 caatgctgct gtcttcttgc tatg 24 <210> 1187 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1187 caatgggaaa aagttaacaa aatg 24 <210> 1188 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1188 tgcaagtatc aagaaaaata tatg 24 <210> 1189 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1189 tcttgatact tgcagaaatg attt 24 <210> 1190 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1190 cttgatactt gcagaaatga tttg 24 <210> 1191 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1191 ttgatacttg cagaaatgat ttgt 24 <210> 1192 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1192 ttttcaggga actgtagaat ttat 24 <210> 1193 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1193 catggagggt actgaaataa attc 24 <210> 1194 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1194 ccatggaggg tactgaaata aatt 24 <210> 1195 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1195 cagggaactg tagaatttat ttca 24 <210> 1196 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1196 tccatggagg gtactgaaat aaat 24 <210> 1197 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1197 agggaactgt agaatttatt tcag 24 <210> 1198 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1198 ttccatggag ggtactgaaa taaa 24 <210> 1199 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1199 cctgtctttt ttccatggag ggta 24 <210> 1200 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1200 ccctgtcttt tttccatgga gggt 24 <210> 1201 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1201 tccctgtctt ttttccatgg aggg 24 <210> 1202 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1202 tttcagtacc ctccatggaa aaaa 24 <210> 1203 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1203 agtaccctcc atggaaaaaa gaca 24 <210> 1204 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1204 agtttgcatg gttcttgctc aagg 24 <210> 1205 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1205 ataagaaaat gcattccttg agca 24 <210> 1206 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1206 cataagaaaa tgcattcctt gagc 24 <210> 1207 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1207 catggttctt gctcaaggaa tgca 24 <210> 1208 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1208 acctacatgt ggaaataaat tttc 24 <210> 1209 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1209 gacctacatg tggaaataaa tttt 24 <210> 1210 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1210 tgacctacat gtggaaataa attt 24 <210> 1211 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1211 cttatgaaaa tttatttcca catg 24 <210> 1212 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1212 ttatgaaaat ttatttccac atgt 24 <210> 1213 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1213 attacatttt tgacctacat gtgg 24 <210> 1214 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1214 cattacattt ttgacctaca tgtg 24 <210> 1215 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1215 tcattacatt tttgacctac atgt 24 <210> 1216 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1216 tttccacatg taggtcaaaa atgt 24 <210> 1217 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1217 cacatgtagg tcaaaaatgt aatg 24 <210> 1218 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1218 ttgcaatcca gccatgatat tttt 24 <210> 1219 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1219 actgttggtt tgttgcaatc cagc 24 <210> 1220 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1220 cactgttggt ttgttgcaat ccag 24 <210> 1221 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1221 aatgctctca tccatagtca tagg 24 <210> 1222 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1222 atgtctcagt aatcttctta ccta 24 <210> 1223 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1223 caagttattt aatgtctcag taat 24 <210> 1224 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1224 acaagttatt taatgtctca gtaa 24 <210> 1225 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1225 gactctgatg acatattttt cccc 24 <210> 1226 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1226 tccccagtat ggttccagat catg 24 <210> 1227 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1227 ccccagtatg gttccagatc atgt 24 <210> 1228 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1228 cccagtatgg ttccagatca tgtc 24 <210> 1229 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1229 tatttgtctt tgtgtatgtg tgta 24 <210> 1230 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1230 tctttgtgta tgtgtgtatg tgta 24 <210> 1231 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1231 tgtatgtgtg tatgtgtatg tgtt 24 <210> 1232 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1232 aggccagacc tatttgactg gaat 24 <210> 1233 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1233 ggccagacct atttgactgg aata 24 <210> 1234 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1234 actggaatag tgtggtttgc cagc 24 <210> 1235 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1235 ccagcagtca gccacacaac gact 24 <210> 1236 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1236 tctatgccta attgatatct ggcg 24 <210> 1237 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1237 ccaaccttca ggatcgagta gttt 24 <210> 1238 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1238 tggactacca ctgcttttag tatg 24 <210> 1239 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1239 agtatggtag agtttaatgt tttc 24 <210> 1240 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1240 gtatggtaga gtttaatgtt ttca 24 <210> 1241 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1241 agactctaaa aggataatga acaa 24 <210> 1242 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1242 actttgattt gttcattatc cttt 24 <210> 1243 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1243 tatatttgag actctaaaag gata 24 <210> 1244 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1244 atttgttcat tatcctttta gagt 24 <210> 1245 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1245 gtttctatat ttgagactct aaaa 24 <210> 1246 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1246 ggtttctata tttgagactc taaa 24 <210> 1247 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1247 tggtttctat atttgagact ctaa 24 <210> 1248 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1248 ttcattatcc ttttagagtc tcaa 24 <210> 1249 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1249 agagtctcaa atatagaaac caaa 24 <210> 1250 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1250 gagtctcaaa tatagaaacc aaaa 24 <210> 1251 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1251 cacttcctgg atggcttcaa tgct 24 <210> 1252 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1252 gcctcaacaa gtgagcattg aagc 24 <210> 1253 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1253 cctcaacaag tgagcattga agcc 24 <210> 1254 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1254 ggtggccttg gcaacatttc cact 24 <210> 1255 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1255 gtcactttag gtggccttgg caac 24 <210> 1256 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1256 atgatgtaac tgaaaatgtt cttc 24 <210> 1257 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1257 cctgttgaga atagtgcatt tgat 24 <210> 1258 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1258 cagttacatc atcaaatgca ctat 24 <210> 1259 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1259 agttacatca tcaaatgcac tatt 24 <210> 1260 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1260 cacactttac ctgttgagaa tagt 24 <210> 1261 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1261 ctgttttata tgcattttta ggta 24 <210> 1262 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1262 tgttttatat gcatttttag gtat 24 <210> 1263 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1263 atatgcattt ttaggtatta cgtg 24 <210> 1264 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1264 tatgcatttt taggtattac gtgc 24 <210> 1265 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1265 taggtattac gtgcacatat atat 24 <210> 1266 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1266 aggtattacg tgcacatata tata 24 <210> 1267 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1267 ggtattacgt gcacatatat atat 24 <210> 1268 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1268 agcaacaact ataatattgt gcag 24 <210> 1269 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1269 gttcctccat ctttctcttt ttat 24 <210> 1270 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1270 tctttttatg gagttcacta ggtg 24 <210> 1271 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1271 tatggagttc actaggtgca ccat 24 <210> 1272 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1272 atggagttca ctaggtgcac catt 24 <210> 1273 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1273 tggagttcac taggtgcacc attc 24 <210> 1274 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1274 ataattgcat ctgaacattt ggtc 24 <210> 1275 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1275 gtcctttgca gggtgagtga gcga 24 <210> 1276 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1276 ttccaaagca gcctctcgct cact 24 <210> 1277 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1277 cagggtgagt gagcgagagg ctgc 24 <210> 1278 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1278 gaagaaactc atagattact gcaa 24 <210> 1279 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1279 caggtccagg gggaactgtt gcag 24 <210> 1280 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1280 ccaggtccag ggggaactgt tgca 24 <210> 1281 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1281 agcttctgta agccaggcaa gaaa 24 <210> 1282 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1282 ttgcctggct tacagaagct gaaa 24 <210> 1283 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1283 cttacgggta gcatcctgta ggac 24 <210> 1284 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1284 ctcccttgga gtcttctagg agcc 24 <210> 1285 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1285 actcccttgg agtcttctag gagc 24 <210> 1286 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1286 atcagctctt ttactccctt ggag 24 <210> 1287 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1287 cgctttagca ctcttgtgga tcca 24 <210> 1288 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1288 gcactcttgt ggatccaatt gaac 24 <210> 1289 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1289 tccctggctt gtcagttaca agta 24 <210> 1290 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1290 gtccctggct tgtcagttac aagt 24 <210> 1291 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1291 ttttgtccct ggcttgtcag ttac 24 <210> 1292 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1292 gttttgtccc tggcttgtca gtta 24 <210> 1293 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1293 tacttgtaac tgacaagcca ggga 24 <210> 1294 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1294 gctcctactc agactgttac tctg 24 <210> 1295 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1295 taccatgtat tgctaaacaa agta 24 <210> 1296 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1296 attgaagagt aacaatttga gcca 24 <210> 1297 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1297 aggctctgca aagttctttg aaag 24 <210> 1298 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1298 aaagagcaac aaaatggctt caac 24 <210> 1299 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1299 aaagagcaat aaaatggctt caac 24 <210> 1300 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1300 aaagaacttt gcagagcctc aaaa 24 <210> 1301 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1301 ctgaatatct atgcattaat aact 24 <210> 1302 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1302 tattatatta cagggcatat tata 24 <210> 1303 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1303 aggtaagccg aggtttggcc ttta 24 <210> 1304 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1304 cccagagtcc ttcaaagata ttga 24 <210> 1305 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1305 ucuuuuucuu cuuuuuuccu uuuu 24 <210> 1306 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1306 cuuuuucuuc uuuuuuccuu uuug 24 <210> 1307 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1307 uuuuucuucu uuuuuccuuu uugc 24 <210> 1308 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1308 ucuucuuuuu uccuuuuugc aaaa 24 <210> 1309 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1309 cuucuuuuuu ccuuuuugca aaaa 24 <210> 1310 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1310 uucuuuuuuc cuuuuugcaa aaac 24 <210> 1311 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1311 uuccuuuuug caaaaaccca aaau 24 <210> 1312 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1312 uccuuuuugc aaaaacccaa aaua 24 <210> 1313 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1313 ccuuuuugca aaaacccaaa auau 24 <210> 1314 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1314 cuuuuugcaa aaacccaaaa uauu 24 <210> 1315 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1315 ugcaaaaacc caaaauauuu uagc 24 <210> 1316 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1316 gcaaaaaccc aaaauauuuu agcu 24 <210> 1317 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1317 caaaaaccca aaauauuuua gcuc 24 <210> 1318 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1318 agcuccuacu cagacuguua cucu 24 <210> 1319 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1319 gcuccuacuc agacuguuac ucug 24 <210> 1320 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1320 cuuaguaacc acagguugug ucac 24 <210> 1321 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1321 gagauggcag uuuccuuagu aacc 24 <210> 1322 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1322 uaguuuggag auggcaguuu ccuu 24 <210> 1323 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1323 uucucauacc uucugcuuga ugau 24 <210> 1324 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1324 ucauuuuuuc ucauaccuuc ugcu 24 <210> 1325 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1325 aucauuuuuu cucauaccuu cugc 24 <210> 1326 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1326 aagaaaaacu ucugccaacu uuua 24 <210> 1327 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1327 aaagaaaaac uucugccaac uuuu 24 <210> 1328 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1328 ucuuuaaaau gaagauuuuc cacc 24 <210> 1329 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1329 cuuuaaaaug aagauuuucc acca 24 <210> 1330 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1330 uuuaaaauga agauuuucca ccaa 24 <210> 1331 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1331 aaaugaagau uuuccaccaa ucac 24 <210> 1332 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1332 ccaccaauca cuuuacucuc cuag 24 <210> 1333 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1333 caccaaucac uuuacucucc uaga 24 <210> 1334 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1334 cucuccuaga ccauuuccca ccag 24 <210> 1335 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1335 agaaaagauu aaacagugug cuac 24 <210> 1336 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1336 uuugagaaaa gauuaaacag ugug 24 <210> 1337 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1337 auuugagaaa agauuaaaca gugu 24 <210> 1338 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1338 uauuugagaa aagauuaaac agug 24 <210> 1339 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1339 aucuuuucuc aaauaaaaag acau 24 <210> 1340 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1340 cucaaauaaa aagacauggg gcuu 24 <210> 1341 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1341 ucaaauaaaa agacaugggg cuuc 24 <210> 1342 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1342 uguuuugccu uuuugguauc uuac 24 <210> 1343 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1343 guuuugccuu uuugguaucu uaca 24 <210> 1344 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1344 uuuugccuuu uugguaucuu acag 24 <210> 1345 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1345 gccuuuuugg uaucuuacag gaac 24 <210> 1346 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1346 ccuuuuuggu aucuuacagg aacu 24 <210> 1347 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1347 ugguaucuua caggaacucc agga 24 <210> 1348 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1348 gguaucuuac aggaacucca ggau 24 <210> 1349 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1349 aggauugcug aauuauuucu uccc 24 <210> 1350 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1350 gaggauugcu gaauuauuuc uucc 24 <210> 1351 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1351 ugaggauugc ugaauuauuu cuuc 24 <210> 1352 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1352 cuguagaaua cuggcaucug uuuu 24 <210> 1353 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1353 ccuguagaau acuggcaucu guuu 24 <210> 1354 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1354 uccuguagaa uacuggcauc uguu 24 <210> 1355 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1355 cagaccuccu gccaccgcag auuc 24 <210> 1356 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1356 ugucugacag cuguuugcag accu 24 <210> 1357 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1357 cugucugaca gcuguuugca gacc 24 <210> 1358 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1358 ucugucugac agcuguuugc agac 24 <210> 1359 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1359 uucugucuga cagcuguuug caga 24 <210> 1360 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1360 auuccuauua gaucugucgc ccua 24 <210> 1361 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1361 cauuccuauu agaucugucg cccu 24 <210> 1362 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1362 agcagacuuu uuaagcuuuc uuua 24 <210> 1363 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1363 gcagacuuuu uaagcuuucu uuag 24 <210> 1364 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1364 uaagcuuucu uuagaagaau auuu 24 <210> 1365 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1365 aagcuuucuu uagaagaaua uuuc 24 <210> 1366 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1366 agcuuucuuu agaagaauau uuca 24 <210> 1367 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1367 uuuagaagaa uauuucauga gaga 24 <210> 1368 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1368 gaagaauauu ucaugagaga uuau 24 <210> 1369 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1369 ucaguauaac caaaaaauau acgc 24 <210> 1370 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1370 acauaaucca ucuauuuuuc uuga 24 <210> 1371 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1371 cauaauccau cuauuuuucu ugau 24 <210> 1372 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1372 ucuugaucca uaugcuuuua ccug 24 <210> 1373 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1373 cuugauccau augcuuuuac cugc 24 <210> 1374 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1374 uugauccaua ugcuuuuacc ugca 24 <210> 1375 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1375 ucaacagauc ugucaaaucg ccug 24 <210> 1376 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1376 accugcaggc gauuugacag aucu 24 <210> 1377 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1377 ccugcaggcg auuugacaga ucug 24 <210> 1378 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1378 acagaucugu ugagaaaugg cggc 24 <210> 1379 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1379 uaucauaaug aaaacgccgc cauu 24 <210> 1380 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1380 cauuaugaua uaaagauauu uaau 24 <210> 1381 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1381 uauuuagcau guucccaauu cuca 24 <210> 1382 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1382 gaaaaaacaa aucaaagacu uacc 24 <210> 1383 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1383 auuuguuuuu ucgaaauugu auuu 24 <210> 1384 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1384 uuuuuucgaa auuguauuua ucuu 24 <210> 1385 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1385 uucgaaauug uauuuaucuu cagc 24 <210> 1386 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1386 ucgaaauugu auuuaucuuc agca 24 <210> 1387 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1387 cgaaauugua uuuaucuuca gcac 24 <210> 1388 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1388 gaaauuguau uuaucuucag caca 24 <210> 1389 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1389 agaaguuaaa gaguccagau gugc 24 <210> 1390 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1390 ucuucagcac aucuggacuc uuua 24 <210> 1391 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1391 caucacccuu cagaaccuga ucuu 24 <210> 1392 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1392 acuucuuaaa gaucagguuc ugaa 24 <210> 1393 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1393 gacuguuguu gucaucauua uauu 24 <210> 1394 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1394 acuguuguug ucaucauuau auua 24 <210> 1395 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1395 aacuagaaua aaaggaaaaa uaaa 24 <210> 1396 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1396 cuacuauaua uuuauuuuuc cuuu 24 <210> 1397 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1397 uuuuuccuuu uauucuaguu gaaa 24 <210> 1398 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1398 uccuuuuauu cuaguugaaa gaau 24 <210> 1399 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1399 ccuuuuauuc uaguugaaag aauu 24 <210> 1400 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1400 cuuuuauucu aguugaaaga auuc 24 <210> 1401 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1401 auucuaguug aaagaauuca gaau 24 <210> 1402 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1402 uucuaguuga aagaauucag aauc 24 <210> 1403 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1403 auucaacugu ugccuccggu ucug 24 <210> 1404 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1404 acauuucauu caacuguugc cucc 24 <210> 1405 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1405 cuuuuggauu gcaucuacug uaua 24 <210> 1406 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1406 ugugauuuuc uuuuggauug cauc 24 <210> 1407 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1407 auacuaaccu ugguuucugu gauu 24 <210> 1408 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1408 aaaagguauc uuugauacua accu 24 <210> 1409 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1409 aaaaagguau cuuugauacu aacc 24 <210> 1410 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1410 uuuuaaaaag guaucuuuga uacu 24 <210> 1411 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1411 auuuuaaaaa gguaucuuug auac 24 <210> 1412 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1412 uuaaugcaaa cugggacaca aaca 24 <210> 1413 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1413 uaaauugcca uguuuguguc ccag 24 <210> 1414 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1414 aaauugccau guuugugucc cagu 24 <210> 1415 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1415 aauugccaug uuuguguccc aguu 24 <210> 1416 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1416 ugucccaguu ugcauuaaca aaua 24 <210> 1417 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1417 caacauaguu cucaaacuau uugu 24 <210> 1418 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1418 ccaacauagu ucucaaacua uuug 24 <210> 1419 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1419 uccaacauag uucucaaacu auuu 24 <210> 1420 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1420 uuuccaacau aguucucaaa cuau 24 <210> 1421 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1421 uuuuccaaca uaguucucaa acua 24 <210> 1422 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1422 uuuuuccaac auaguucuca aacu 24 <210> 1423 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1423 cauuaacaaa uaguuugaga acua 24 <210> 1424 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1424 agaacuaugu uggaaaaaaa aaua 24 <210> 1425 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1425 guucuucuag ccuggagaaa gaag 24 <210> 1426 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1426 auucuucuuu cuccaggcua gaag 24 <210> 1427 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1427 uucuucuuuc uccaggcuag aaga 24 <210> 1428 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1428 uccaggcuag aagaacaaaa gaau 24 <210> 1429 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1429 aaauucugac aagauauucu uuug 24 <210> 1430 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1430 cuuuuaguug cugcucuuuu ccag 24 <210> 1431 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1431 agaaaauaaa auuaccuuga cuug 24 <210> 1432 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1432 ugcaagcagg cccuggggga uuug 24 <210> 1433 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1433 auuuucucaa aucccccagg gccu 24 <210> 1434 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1434 uuuucucaaa ucccccaggg ccug 24 <210> 1435 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1435 cucaaauccc ccagggccug cuug 24 <210> 1436 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1436 ucaaaucccc cagggccugc uugc 24 <210> 1437 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1437 uuaauucaau cauugguuuu cugc 24 <210> 1438 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1438 uaauucaauc auugguuuuc ugcc 24 <210> 1439 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1439 aauucaauca uugguuuucu gccc 24 <210> 1440 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1440 auucaaucau ugguuuucug ccca 24 <210> 1441 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1441 gcaaggaacu augaauaacc uaau 24 <210> 1442 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1442 cugcccauua gguuauucau aguu 24 <210> 1443 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1443 ugcccauuag guuauucaua guuc 24 <210> 1444 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1444 uagaaaacaa uuuaacagga aaua 24 <210> 1445 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1445 cuguuaaauu guuuucuaua aacc 24 <210> 1446 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1446 gaaauaaaaa agauguuacu guau 24 <210> 1447 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1447 agaaauaaaa aagauguuac ugua 24 <210> 1448 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1448 cuauaaaccc uuauacagua acau 24 <210> 1449 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1449 uauaaacccu uauacaguaa cauc 24 <210> 1450 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1450 uuauuucuaa aaguguuuug gcug 24 <210> 1451 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1451 uauuucuaaa aguguuuugg cugg 24 <210> 1452 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1452 auuucuaaaa guguuuuggc uggu 24 <210> 1453 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1453 uuucuaaaag uguuuuggcu gguc 24 <210> 1454 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1454 uaaaaguguu uuggcugguc ucac 24 <210> 1455 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1455 cauaauacaa aguaaaguac aauu 24 <210> 1456 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1456 acauaauaca aaguaaagua caau 24 <210> 1457 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1457 ggcuggucuc acaauuguac uuua 24 <210> 1458 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1458 gcuggucuca caauuguacu uuac 24 <210> 1459 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1459 cuuuguauua uguaaaagga auac 24 <210> 1460 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1460 uauuauguaa aaggaauaca caac 24 <210> 1461 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1461 uucuuacagg caacaaugca ggau 24 <210> 1462 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1462 gaacagaggc guccccaguu ggaa 24 <210> 1463 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1463 ggcagcggua augaguucuu ccaa 24 <210> 1464 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1464 ucaaauuuug ggcagcggua auga 24 <210> 1465 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1465 aaaaacaaga ccagcaauca agag 24 <210> 1466 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1466 ugugucccau gcuuguuaaa aaac 24 <210> 1467 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1467 uuaacaagca ugggacacac aaag 24 <210> 1468 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1468 uaacaagcau gggacacaca aagc 24 <210> 1469 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1469 aacaagcaug ggacacacaa agca 24 <210> 1470 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1470 acaagcaugg gacacacaaa gcaa 24 <210> 1471 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1471 uugaaacuug ucaugcaucu ugcu 24 <210> 1472 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1472 auugaaacuu gucaugcauc uugc 24 <210> 1473 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1473 uauugaaacu ugucaugcau cuug 24 <210> 1474 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1474 aauaaaaacu uaaguucaua uauc 24 <210> 1475 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1475 gugaauauau uauuggauuu cuau 24 <210> 1476 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1476 aagauaauuc augaacaucu uaau 24 <210> 1477 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1477 acagaaaagc auacacauua cuua 24 <210> 1478 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1478 cuguuaaaga ggaaguuaga agau 24 <210> 1479 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1479 uguuaaagag gaaguuagaa gauc 24 <210> 1480 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1480 ccgccuucca cucagagcuc agau 24 <210> 1481 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1481 cccucagcuc uugaaguaaa cggu 24 <210> 1482 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1482 cuucaagagc ugagggcaaa gcag 24 <210> 1483 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1483 aacaaauagc uagagccaaa gaga 24 <210> 1484 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1484 gaacaaauag cuagagccaa agag 24 <210> 1485 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1485 gcucuagcua uuuguucaaa agug 24 <210> 1486 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1486 uucaaaagug caacuaugaa guga 24 <210> 1487 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1487 ucucucaccc agucaucacu ucau 24 <210> 1488 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1488 cucucucacc cagucaucac uuca 24 <210> 1489 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1489 uauauauaua uauauuuuuc ucuu 24 <210> 1490 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1490 ucucuuucua uagacagcua auuc 24 <210> 1491 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1491 cucuuucuau agacagcuaa uuca 24 <210> 1492 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1492 aaacaguaaa aaaaugaauu agcu 24 <210> 1493 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1493 ucuuucuaua gacagcuaau ucau 24 <210> 1494 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1494 aaaacaguaa aaaaaugaau uagc 24 <210> 1495 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1495 uauagacagc uaauucauuu uuuu 24 <210> 1496 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1496 uauucuguaa uauaaaaauu uuaa 24 <210> 1497 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1497 auauucugua auauaaaaau uuua 24 <210> 1498 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1498 uuuacuguuu uaaaauuuuu auau 24 <210> 1499 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1499 uuacuguuuu aaaauuuuua uauu 24 <210> 1500 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1500 uacuguuuua aaauuuuuau auua 24 <210> 1501 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1501 acuguuuuaa aauuuuuaua uuac 24 <210> 1502 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1502 cuguuuuaaa auuuuuauau uaca 24 <210> 1503 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1503 aaaauuuuua uauuacagaa uaua 24 <210> 1504 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1504 aaauuuuuau auuacagaau auaa 24 <210> 1505 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1505 uuguagacua ucuuuuauau ucug 24 <210> 1506 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1506 uauauuacag aauauaaaag auag 24 <210> 1507 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1507 auauuacaga auauaaaaga uagu 24 <210> 1508 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1508 uauuacagaa uauaaaagau aguc 24 <210> 1509 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1509 caaugcugcu gucuucuugc uaug 24 <210> 1510 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1510 caaugggaaa aaguuaacaa aaug 24 <210> 1511 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1511 ugcaaguauc aagaaaaaua uaug 24 <210> 1512 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1512 ucuugauacu ugcagaaaug auuu 24 <210> 1513 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1513 cuugauacuu gcagaaauga uuug 24 <210> 1514 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1514 uugauacuug cagaaaugau uugu 24 <210> 1515 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1515 uuuucaggga acuguagaau uuau 24 <210> 1516 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1516 cauggagggu acugaaauaa auuc 24 <210> 1517 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1517 ccauggaggg uacugaaaua aauu 24 <210> 1518 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1518 cagggaacug uagaauuuau uuca 24 <210> 1519 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1519 uccauggagg guacugaaau aaau 24 <210> 1520 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1520 agggaacugu agaauuuauu ucag 24 <210> 1521 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1521 uuccauggag gguacugaaa uaaa 24 <210> 1522 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1522 ccugucuuuu uuccauggag ggua 24 <210> 1523 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1523 cccugucuuu uuuccaugga gggu 24 <210> 1524 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1524 ucccugucuu uuuuccaugg aggg 24 <210> 1525 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1525 uuucaguacc cuccauggaa aaaa 24 <210> 1526 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1526 aguacccucc auggaaaaaa gaca 24 <210> 1527 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1527 aguuugcaug guucuugcuc aagg 24 <210> 1528 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1528 auaagaaaau gcauuccuug agca 24 <210> 1529 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1529 cauaagaaaa ugcauuccuu gagc 24 <210> 1530 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1530 caugguucuu gcucaaggaa ugca 24 <210> 1531 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1531 accuacaugu ggaaauaaau uuuc 24 <210> 1532 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1532 gaccuacaug uggaaauaaa uuuu 24 <210> 1533 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1533 ugaccuacau guggaaauaa auuu 24 <210> 1534 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1534 cuuaugaaaa uuuauuucca caug 24 <210> 1535 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1535 uuaugaaaau uuauuuccac augu 24 <210> 1536 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1536 auuacauuuu ugaccuacau gugg 24 <210> 1537 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1537 cauuacauuu uugaccuaca ugug 24 <210> 1538 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1538 ucauuacauu uuugaccuac augu 24 <210> 1539 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1539 uuuccacaug uaggucaaaa augu 24 <210> 1540 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1540 cacauguagg ucaaaaaugu aaug 24 <210> 1541 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1541 uugcaaucca gccaugauau uuuu 24 <210> 1542 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1542 acuguugguu uguugcaauc cagc 24 <210> 1543 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1543 cacuguuggu uuguugcaau ccag 24 <210> 1544 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1544 aaugcucuca uccauaguca uagg 24 <210> 1545 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1545 augucucagu aaucuucuua ccua 24 <210> 1546 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1546 caaguuauuu aaugucucag uaau 24 <210> 1547 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1547 acaaguuauu uaaugucuca guaa 24 <210> 1548 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1548 gacucugaug acauauuuuu cccc 24 <210> 1549 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1549 uccccaguau gguuccagau caug 24 <210> 1550 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1550 ccccaguaug guuccagauc augu 24 <210> 1551 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1551 cccaguaugg uuccagauca uguc 24 <210> 1552 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1552 uauuugucuu uguguaugug ugua 24 <210> 1553 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1553 ucuuugugua uguguguaug ugua 24 <210> 1554 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1554 uguaugugug uauguguaug uguu 24 <210> 1555 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1555 aggccagacc uauuugacug gaau 24 <210> 1556 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1556 ggccagaccu auuugacugg aaua 24 <210> 1557 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1557 acuggaauag ugugguuugc cagc 24 <210> 1558 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1558 ccagcaguca gccacacaac gacu 24 <210> 1559 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1559 ucuaugccua auugauaucu ggcg 24 <210> 1560 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1560 ccaaccuuca ggaucgagua guuu 24 <210> 1561 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1561 uggacuacca cugcuuuuag uaug 24 <210> 1562 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1562 aguaugguag aguuuaaugu uuuc 24 <210> 1563 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1563 guaugguaga guuuaauguu uuca 24 <210> 1564 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1564 agacucuaaa aggauaauga acaa 24 <210> 1565 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1565 acuuugauuu guucauuauc cuuu 24 <210> 1566 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1566 uauauuugag acucuaaaag gaua 24 <210> 1567 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1567 auuuguucau uauccuuuua gagu 24 <210> 1568 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1568 guuucuauau uugagacucu aaaa 24 <210> 1569 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1569 gguuucuaua uuugagacuc uaaa 24 <210> 1570 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1570 ugguuucuau auuugagacu cuaa 24 <210> 1571 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1571 uucauuaucc uuuuagaguc ucaa 24 <210> 1572 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1572 agagucucaa auauagaaac caaa 24 <210> 1573 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1573 gagucucaaa uauagaaacc aaaa 24 <210> 1574 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1574 cacuuccugg auggcuucaa ugcu 24 <210> 1575 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1575 gccucaacaa gugagcauug aagc 24 <210> 1576 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1576 ccucaacaag ugagcauuga agcc 24 <210> 1577 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1577 gguggccuug gcaacauuuc cacu 24 <210> 1578 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1578 gucacuuuag guggccuugg caac 24 <210> 1579 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1579 augauguaac ugaaaauguu cuuc 24 <210> 1580 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1580 ccuguugaga auagugcauu ugau 24 <210> 1581 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1581 caguuacauc aucaaaugca cuau 24 <210> 1582 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1582 aguuacauca ucaaaugcac uauu 24 <210> 1583 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1583 cacacuuuac cuguugagaa uagu 24 <210> 1584 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1584 cuguuuuaua ugcauuuuua ggua 24 <210> 1585 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1585 uguuuuauau gcauuuuuag guau 24 <210> 1586 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1586 auaugcauuu uuagguauua cgug 24 <210> 1587 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1587 uaugcauuuu uagguauuac gugc 24 <210> 1588 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1588 uagguauuac gugcacauau auau 24 <210> 1589 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1589 agguauuacg ugcacauaua uaua 24 <210> 1590 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1590 gguauuacgu gcacauauau auau 24 <210> 1591 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1591 agcaacaacu auaauauugu gcag 24 <210> 1592 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1592 guuccuccau cuuucucuuu uuau 24 <210> 1593 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1593 ucuuuuuaug gaguucacua ggug 24 <210> 1594 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1594 uauggaguuc acuaggugca ccau 24 <210> 1595 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1595 auggaguuca cuaggugcac cauu 24 <210> 1596 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1596 uggaguucac uaggugcacc auuc 24 <210> 1597 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1597 auaauugcau cugaacauuu gguc 24 <210> 1598 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1598 guccuuugca gggugaguga gcga 24 <210> 1599 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1599 uuccaaagca gccucucgcu cacu 24 <210> 1600 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1600 cagggugagu gagcgagagg cugc 24 <210> 1601 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1601 gaagaaacuc auagauuacu gcaa 24 <210> 1602 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1602 cagguccagg gggaacuguu gcag 24 <210> 1603 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1603 ccagguccag ggggaacugu ugca 24 <210> 1604 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1604 agcuucugua agccaggcaa gaaa 24 <210> 1605 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1605 uugccuggcu uacagaagcu gaaa 24 <210> 1606 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1606 cuuacgggua gcauccugua ggac 24 <210> 1607 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1607 cucccuugga gucuucuagg agcc 24 <210> 1608 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1608 acucccuugg agucuucuag gagc 24 <210> 1609 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1609 aucagcucuu uuacucccuu ggag 24 <210> 1610 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1610 cgcuuuagca cucuugugga ucca 24 <210> 1611 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1611 gcacucuugu ggauccaauu gaac 24 <210> 1612 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1612 ucccuggcuu gucaguuaca agua 24 <210> 1613 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1613 gucccuggcu ugucaguuac aagu 24 <210> 1614 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1614 uuuugucccu ggcuugucag uuac 24 <210> 1615 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1615 guuuuguccc uggcuuguca guua 24 <210> 1616 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1616 uacuuguaac ugacaagcca ggga 24 <210> 1617 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1617 gcuccuacuc agacuguuac ucug 24 <210> 1618 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1618 uaccauguau ugcuaaacaa agua 24 <210> 1619 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1619 auugaagagu aacaauuuga gcca 24 <210> 1620 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1620 aggcucugca aaguucuuug aaag 24 <210> 1621 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1621 aaagagcaac aaaauggcuu caac 24 <210> 1622 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1622 aaagagcaau aaaauggcuu caac 24 <210> 1623 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1623 aaagaacuuu gcagagccuc aaaa 24 <210> 1624 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1624 cugaauaucu augcauuaau aacu 24 <210> 1625 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1625 uauuauauua cagggcauau uaua 24 <210> 1626 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1626 agguaagccg agguuuggcc uuua 24 <210> 1627 <211> 24 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1627 cccagagucc uucaaagaua uuga 24 <210> 1628 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1628 attggctttg atttcccta 19 <210> 1629 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1629 tgtagagtaa gtcagccta 19 <210> 1630 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1630 cctactcaga ctgttactc 19 <210> 1631 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1631 ttggacagaa cttaccgac 19 <210> 1632 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1632 cagttgccta agaactggt 19 <210> 1633 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1633 gggctccacc ctcacgagt 19 <210> 1634 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1634 tttgcttcgc tataaaacg 19 <210> 1635 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1635 tctgaggatg gggccgcaa 19 <210> 1636 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1636 gatctgtcaa atcgcctgc 19 <210> 1637 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1637 ccaggatggc attgggcag 19 <210> 1638 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1638 ctgaatctgc ggtggcagg 19 <210> 1639 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1639 ttcttttgtt cttctagcc 19 <210> 1640 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1640 gaaaagcttg agcaagtca 19 <210> 1641 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1641 gaagagttgc ccctgcgcc 19 <210> 1642 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1642 acaaatctcc agtggataa 19 <210> 1643 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1643 tgtttctcag gtaaagctc 19 <210> 1644 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1644 gaaggaccat ttgacgtta 19 <210> 1645 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1645 aactgctatt tcagtttcc 19 <210> 1646 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1646 ccagccactc agccagtga 19 <210> 1647 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1647 gtatgctttt ctgttaaag 19 <210> 1648 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1648 ctcctggact gaccactat 19 <210> 1649 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1649 gaacagaggc gtccccagt 19 <210> 1650 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1650 gaggctagaa caatcatta 19 <210> 1651 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1651 acaagaacac cttcagaac 19 <210> 1652 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1652 ggtttctgtg attttcttt 19 <210> 1653 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1653 ggccaaagac ctccgccag 19 <210> 1654 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1654 ttggagaagc attcataaa 19 <210> 1655 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1655 tcgctcactc accctgcaa 19 <210> 1656 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1656 aaaagagctg atgaaacaa 19 <210> 1657 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1657 tacacttttc aaaatgctt 19 <210> 1658 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1658 gagatgatca tcaagcaga 19 <210> 1659 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1659 ctttgaaaga gcaataaaa 19 <210> 1660 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1660 cacaaaagtc aaatcggaa 19 <210> 1661 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1661 atttcaatat aagattcgg 19 <210> 1662 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1662 cttaagcaat cccgaactc 19 <210> 1663 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1663 ccttctttat cccctatcg 19 <210> 1664 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1664 aggccaaacc tcggcttac 19 <210> 1665 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1665 ttcgaaaatt tcaggtaag 19 <210> 1666 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1666 gcagaacagg agataacag 19 <210> 1667 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1667 gcggccctcg cccttctct 19 <210> 1668 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1668 tagtgatcgt ggatacgag 19 <210> 1669 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1669 tacagccctc ggtgtatat 19 <210> 1670 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1670 ggaaggaatt aagcccgaa 19 <210> 1671 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1671 ggaacagctt tcgtagttg 19 <210> 1672 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1672 ataaagtcca gtgtcgatc 19 <210> 1673 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1673 aaaaccagag cttcggtca 19 <210> 1674 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1674 gagtcttctg ggcaggctta a 21 <210> 1675 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1675 tcgggtgagc atgtctttaa t 21 <210> 1676 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1676 gtgtcaccag agtaacagt 19 <210> 1677 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1677 tgatcatcaa gcagaaggt 19 <210> 1678 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1678 aacttcgaaa atttcaggta 20 <210> 1679 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1679 gaaactcatc aaatatgcgt 20 <210> 1680 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1680 tcatttacac taacacgcat 20 <210> 1681 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1681 gaatgaaact catcaaatat 20 <210> 1682 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1682 tcatcaatat ctttgaagga 20 <210> 1683 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1683 tgttttcata ggaaaaatag 20 <210> 1684 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1684 aattggaaaa tgtgatggga 20 <210> 1685 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1685 atgatcatca agcagaaggt 20 <210> 1686 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1686 agatgatcat caagcagaag 20 <210> 1687 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1687 cattttttct cataccttct 20 <210> 1688 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1688 tcctactcag actgttactc 20 <210> 1689 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1689 acaggttgtg tcaccagagt 20 <210> 1690 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1690 ttatcatttt ttctcatacc 20 <210> 1691 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1691 ttgcctaaga actggtggga 20 <210> 1692 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1692 aaacagttgc ctaagaactg 20 <210> 1693 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1693 tttcccacca gttcttaggc 20 <210> 1694 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1694 tggctttgat ttccctaggg 20 <210> 1695 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1695 tagggaaatc aaagccaatg 20 <210> 1696 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1696 gaccctaggg aaatcaaagc 20 <210> 1697 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1697 tgagggctcc accctcacga 20 <210> 1698 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1698 aaggattgag ggctccaccc 20 <210> 1699 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1699 gctccaccct cacgagtggg 20 <210> 1700 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1700 tatcccctat cgaggaaacc 20 <210> 1701 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1701 gataaagaag gcctatttca 20 <210> 1702 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1702 aggccttctt tatcccctat 20 <210> 1703 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1703 tgagggctcc accctcacga 20 <210> 1704 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1704 gataaagaag gcctatttca 20 <210> 1705 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1705 attggctttg atttcccta 19 <210> 1706 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1706 tgtagagtaa gtcagccta 19 <210> 1707 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1707 cctactcaga ctgttactc 19 <210> 1708 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1708 ttggacagaa cttaccgac 19 <210> 1709 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1709 cagttgccta agaactggt 19 <210> 1710 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1710 gggctccacc ctcacgagt 19 <210> 1711 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1711 tttgcttcgc tataaaacg 19 <210> 1712 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1712 tctgaggatg gggccgcaa 19 <210> 1713 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1713 gatctgtcaa atcgcctgc 19 <210> 1714 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1714 ccaggatggc attgggcag 19 <210> 1715 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1715 ctgaatctgc ggtggcagg 19 <210> 1716 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1716 ttcttttgtt cttctagcc 19 <210> 1717 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1717 gaaaagcttg agcaagtca 19 <210> 1718 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1718 gaagagttgc ccctgcgcc 19 <210> 1719 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1719 acaaatctcc agtggataa 19 <210> 1720 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1720 tgtttctcag gtaaagctc 19 <210> 1721 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1721 gaaggaccat ttgacgtta 19 <210> 1722 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1722 aactgctatt tcagtttcc 19 <210> 1723 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1723 ccagccactc agccagtga 19 <210> 1724 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1724 gtatgctttt ctgttaaag 19 <210> 1725 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1725 ctcctggact gaccactat 19 <210> 1726 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1726 gaacagaggc gtccccagt 19 <210> 1727 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1727 gaggctagaa caatcatta 19 <210> 1728 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1728 acaagaacac cttcagaac 19 <210> 1729 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1729 ggtttctgtg attttcttt 19 <210> 1730 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1730 ggccaaagac ctccgccag 19 <210> 1731 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1731 ttggagaagc attcataaa 19 <210> 1732 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1732 tcgctcactc accctgcaa 19 <210> 1733 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1733 aaaagagctg atgaaacaa 19 <210> 1734 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1734 tacacttttc aaaatgctt 19 <210> 1735 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1735 gagatgatca tcaagcaga 19 <210> 1736 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1736 ctttgaaaga gcaataaaa 19 <210> 1737 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1737 cacaaaagtc aaatcggaa 19 <210> 1738 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1738 atttcaatat aagattcgg 19 <210> 1739 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1739 cttaagcaat cccgaactc 19 <210> 1740 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1740 ccttctttat cccctatcg 19 <210> 1741 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1741 aggccaaacc tcggcttac 19 <210> 1742 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1742 ttcgaaaatt tcaggtaag 19 <210> 1743 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1743 gcagaacagg agataacag 19 <210> 1744 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1744 gcggccctcg cccttctct 19 <210> 1745 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1745 tagtgatcgt ggatacgag 19 <210> 1746 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1746 tacagccctc ggtgtatat 19 <210> 1747 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1747 ggaaggaatt aagcccgaa 19 <210> 1748 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1748 ggaacagctt tcgtagttg 19 <210> 1749 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1749 ataaagtcca gtgtcgatc 19 <210> 1750 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1750 aaaaccagag cttcggtca 19 <210> 1751 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1751 gagtcttctg ggcaggctta a 21 <210> 1752 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1752 tcgggtgagc atgtctttaa t 21 <210> 1753 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1753 gtgtcaccag agtaacagt 19 <210> 1754 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1754 tgatcatcaa gcagaaggt 19 <210> 1755 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1755 aacttcgaaa atttcaggta 20 <210> 1756 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1756 gaaactcatc aaatatgcgt 20 <210> 1757 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1757 tcatttacac taacacgcat 20 <210> 1758 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1758 gaatgaaact catcaaatat 20 <210> 1759 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1759 tcatcaatat ctttgaagga 20 <210> 1760 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1760 tgttttcata ggaaaaatag 20 <210> 1761 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1761 aattggaaaa tgtgatggga 20 <210> 1762 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1762 atgatcatca agcagaaggt 20 <210> 1763 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1763 agatgatcat caagcagaag 20 <210> 1764 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1764 cattttttct cataccttct 20 <210> 1765 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1765 tcctactcag actgttactc 20 <210> 1766 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1766 acaggttgtg tcaccagagt 20 <210> 1767 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1767 ttatcatttt ttctcatacc 20 <210> 1768 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1768 ttgcctaaga actggtggga 20 <210> 1769 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1769 aaacagttgc ctaagaactg 20 <210> 1770 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1770 tttcccacca gttcttaggc 20 <210> 1771 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1771 tggctttgat ttccctaggg 20 <210> 1772 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1772 tagggaaatc aaagccaatg 20 <210> 1773 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1773 gaccctaggg aaatcaaagc 20 <210> 1774 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1774 tgagggctcc accctcacga 20 <210> 1775 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1775 aaggattgag ggctccaccc 20 <210> 1776 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1776 gctccaccct cacgagtggg 20 <210> 1777 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1777 tatcccctat cgaggaaacc 20 <210> 1778 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1778 gataaagaag gcctatttca 20 <210> 1779 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1779 aggccttctt tatcccctat 20 <210> 1780 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1780 tgagggctcc accctcacga 20 <210> 1781 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1781 gataaagaag gcctatttca 20 <210> 1782 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1782 uagaagaucu gagcucugag 20 <210> 1783 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1783 agaucugagc ucugagugga 20 <210> 1784 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1784 ucugagcucu gaguggaagg 20 <210> 1785 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1785 ccguuuacuu caagagcuga 20 <210> 1786 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1786 aagcagccug accuagcucc 20 <210> 1787 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1787 gcuccuggac ugaccacuau 20 <210> 1788 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1788 cccucagcuc uugaaguaaa 20 <210> 1789 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1789 gucaguccag gagcuagguc 20 <210> 1790 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1790 uaguggucag uccaggagcu 20 <210> 1791 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1791 gcuccaauag uggucagucc 20 <210> 1792 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1792 uggccaaaga ccuccgccag 20 <210> 1793 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1793 guggcagaca aauguagaug 20 <210> 1794 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1794 uguagaugug gcaaaugacu 20 <210> 1795 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1795 cuuggcccug aaacuucucc 20 <210> 1796 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1796 cagagaauau caaugccucu 20 <210> 1797 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1797 cagagaauau caaugccucu 20 <210> 1798 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1798 cauuugucug ccacuggcgg 20 <210> 1799 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1799 cuacauuugu cugccacugg 20 <210> 1800 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1800 caucuacauu ugucugccac 20 <210> 1801 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1801 auaaucccgg agaaguuuca 20 <210> 1802 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1802 uaucaucugc agaauaaucc 20 <210> 1803 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1803 uguuaucaug uggacuuuuc 20 <210> 1804 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1804 ugauauauca uuucucugug 20 <210> 1805 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1805 uuuaugaaug cuucuccaag 20 <210> 1806 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1806 uucuccaggc uagaagaaca a 21 <210> 1807 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1807 cugcucuuuu ccagguucaa g 21 <210> 1808 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1808 gucuguuuca guuacuggug g 21 <210> 1809 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1809 uccaguuuca uuuaauuguu u 21 <210> 1810 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1810 cuuaugggag cacuuacaag c 21 <210> 1811 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1811 uugcuucauu accuucacug g 21 <210> 1812 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1812 uugugucacc agaguaacag u 21 <210> 1813 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1813 aguaaccaca gguuguguca c 21 <210> 1814 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1814 uucaaauuuu gggcagcggu a 21 <210> 1815 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1815 caagaggcua gaacaaucau u 21 <210> 1816 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1816 uuguacuuca ucccacugau u 21 <210> 1817 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1817 cuucagaacc ggaggcaaca g 21 <210> 1818 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1818 caacaguuga augaaauguu a 21 <210> 1819 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1819 gccaagcuug agucauggaa g 21 <210> 1820 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1820 cuugguuucu gugauuuucu u 21 <210> 1821 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1821 ucauuucaca ggccuucaag a 21 <210> 1822 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1822 cagaaauauu cguacagucu c 21 <210> 1823 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1823 caauuaccuc ugggcuccug g 21 <210> 1824 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1824 gatactaggg tggcaaatag 20 <210> 1825 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1825 gtgttcttaa aagaatggtg 20 <210> 1826 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1826 gtcaagaaca gctgcagaac 20 <210> 1827 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1827 gcagttgaat gaaatgttaa 20 <210> 1828 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1828 gatactagtg tggctcatag 20 <210> 1829 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1829 gatacgatgg tggcaaatcg 20 <210> 1830 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1830 gatactaggg tggggaataa 20 <210> 1831 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1831 tttttcttaa aagaatggta 20 <210> 1832 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1832 ttgatcttag aagaatggtg 20 <210> 1833 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1833 gttttcttga aaaaatggtg 20 <210> 1834 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1834 ctgttcttaa aaggttggtg 20 <210> 1835 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1835 gagttcttca aagaatagtg 20 <210> 1836 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1836 tctagggcag ctgcagaac 19 <210> 1837 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1837 tcattcacag ctgcagaac 19 <210> 1838 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1838 caaagaatag ctgcagaac 19 <210> 1839 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1839 tcaagaacag ctgcagcag 19 <210> 1840 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1840 tcaagaacag ctgcatcac 19 <210> 1841 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1841 cagttacatg aaatgttaa 19 <210> 1842 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1842 cattttaatg aaatgttaa 19 <210> 1843 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1843 aagttgaatg aaattttaa 19 <210> 1844 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1844 cagtggaata aaatgttaa 19 <210> 1845 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1845 aaagatatat aatgtcatga at 22 <210> 1846 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1846 gcagaatcaa atataatagt ct 22 <210> 1847 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1847 aacaaatatc ccttagtatc 20 <210> 1848 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1848 aatgtatttc ttctattcaa 20 <210> 1849 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1849 aacaataagt caaatttaat tg 22 <210> 1850 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1850 gaactggtgg gaaatggtct ag 22 <210> 1851 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1851 tcctttggta aataaaagtc ct 22 <210> 1852 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1852 taggaatcaa atggacttgg at 22 <210> 1853 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1853 taattctttc tagaaagagc ct 22 <210> 1854 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1854 ctcttgcatc ttgcacatgt cc 22 <210> 1855 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1855 acttagaggt cttctacata ca 22 <210> 1856 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1856 tcagaggtga gtggtgaggg ga 22 <210> 1857 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1857 acacacagct gggttatcag ag 22 <210> 1858 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1858 cacagctggg ttatcagag 19 <210> 1859 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1859 acacagctgg gttatcagag 20 <210> 1860 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1860 cacacagctg ggttatcaga g 21 <210> 1861 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1861 aacacacagc tgggttatca gag 23 <210> 1862 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1862 ctgstgggar atggtctag 19 <210> 1863 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1863 actggtggga aatggtctag 20 <210> 1864 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1864 aactggtggg aaatggtcta g 21 <210> 1865 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1865 agaactggtg ggaaatggtc tag 23 <210> 1866 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1866 atatcttctt aaatacccga 20 <210> 1867 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1867 agtctcacaa aactgcagag 20 <210> 1868 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1868 tacttatgta ttttaaaaac 20 <210> 1869 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1869 gaataatttc tattatatta ca 22 <210> 1870 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1870 ttcgaaaatt tcaggtaagc cg 22 <210> 1871 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1871 tcatttctaa aagtcttttg cc 22 <210> 1872 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1872 tttgagacac agtataggtt at 22 <210> 1873 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1873 atataataga aattattcat 20 <210> 1874 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1874 taatatgccc tgtaatataa 20 <210> 1875 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1875 tgatatcatc aatatctttg 20 <210> 1876 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1876 gcaattaatt ggaaaatgtg 20 <210> 1877 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1877 ctttaagctt aggtaaaatc a 21 <210> 1878 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1878 cagtaatgtg tcataccttc 20 <210> 1879 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1879 cagggcatat tatatttaga 20 <210> 1880 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1880 caaaagccaa atctatttca 20 <210> 1881 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1881 atgctttggt gggaagaagt agagga 26 <210> 1882 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1882 atgctttggt gggaagaata gaggac 26 <210> 1883 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1883 ttgtgacaag ctcactaatt agg 23 <210> 1884 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1884 aagtttgaag aacttttacc agg 23 <210> 1885 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1885 aggcagcgat aaaaaaaacc tgg 23 <210> 1886 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1886 gctttggtgg gaagaagtag agg 23 <210> 1887 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1887 gctgggtgtc ccattgaaa 19 <210> 1888 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1888 cagccgctcg ctgcagcag 19 <210> 1889 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1889 tggagagttt gcaaggagc 19 <210> 1890 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1890 gtttattcag ccgggagtc 19 <210> 1891 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1891 cgccaggagg ggtgggtcta 20 <210> 1892 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1892 ccttggtgag actggtaga 19 <210> 1893 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1893 gtcttcaggt tctgttgct 19 <210> 1894 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1894 atattcctga tttaaaagt 19 <210> 1895 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1895 ttaaaagtcg gctggtagc 19 <210> 1896 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1896 cgggccgggg gcggggtcc 19 <210> 1897 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1897 gcccgagccg cgtgtggaa 19 <210> 1898 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1898 ccttcattgc ggcgggctg 19 <210> 1899 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1899 ccgacccctc ccgggtccc 19 <210> 1900 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1900 caggaccgcg cttcccacg 19 <210> 1901 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1901 tgcaccctgg gagcgcgag 19 <210> 1902 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1902 ccgcacgcac ctgttccca 19 <210> 1903 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1903 aaaacagcga gggagaaac 19 <210> 1904 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1904 ttaacttgat tgtgaaatc 19 <210> 1905 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1905 aaaacaatgc atatttgca 19 <210> 1906 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1906 aaaatccagt attttaatg 19 <210> 1907 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1907 acccagcact gcagcctgg 19 <210> 1908 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1908 aacttatgcg gcgtttcct 19 <210> 1909 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1909 tcactttaaa accacctct 19 <210> 1910 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1910 gcatcttttt ctctttaat 19 <210> 1911 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1911 tgtactctct gaggtgctc 19 <210> 1912 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1912 acgcagataa gaaccagtt 19 <210> 1913 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1913 catcaagtca gccatcagc 19 <210> 1914 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1914 gagtcaccct cctggaaac 19 <210> 1915 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1915 gctagggatg aagaataaa 19 <210> 1916 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1916 ttgaccaata gccttgaca 19 <210> 1917 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1917 tgcaaatatc tgtctgaaa 19 <210> 1918 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1918 aaattagcag tatcctctt 19 <210> 1919 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1919 cctgggctcc ggggcgttt 19 <210> 1920 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1920 ggcccctgcg gccaccccg 19 <210> 1921 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1921 ctccctccct gcccggtag 19 <210> 1922 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1922 aggtttggaa agggcgtgc 19 <210> 1923 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1923 gattggcttt gatttcccta 20 <210> 1924 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1924 gtgtagagta agtcagccta tgg 23 <210> 1925 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1925 gcctactcag actgttactc 20 <210> 1926 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1926 gttggacaga acttaccgac tgg 23 <210> 1927 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1927 gcagttgcct aagaactggt 20 <210> 1928 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1928 ggggctccac cctcacgagt 20 <210> 1929 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1929 gtttgcttcg ctataaaacg agg 23 <210> 1930 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1930 gtctgaggat ggggccgcaa tgg 23 <210> 1931 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1931 ggatctgtca aatcgcctgc agg 23 <210> 1932 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1932 gccaggatgg cattgggcag cgg 23 <210> 1933 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1933 gctgaatctg cggtggcagg agg 23 <210> 1934 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1934 gttcttttgt tcttctagcc tgg 23 <210> 1935 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1935 ggaaaagctt gagcaagtca agg 23 <210> 1936 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1936 ggaagagttg cccctgcgcc agg 23 <210> 1937 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1937 gacaaatctc cagtggataa agg 23 <210> 1938 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1938 gtgtttctca ggtaaagctc tgg 23 <210> 1939 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1939 ggaaggacca tttgacgtta agg 23 <210> 1940 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1940 gaactgctat ttcagtttcc tgg 23 <210> 1941 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1941 gccagccact cagccagtga agg 23 <210> 1942 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1942 ggtatgcttt tctgttaaag agg 23 <210> 1943 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1943 gctcctggac tgaccactat tgg 23 <210> 1944 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1944 ggaacagagg cgtccccagt tgg 23 <210> 1945 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1945 ggaggctaga acaatcatta cgg 23 <210> 1946 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1946 gacaagaaca ccttcagaac cgg 23 <210> 1947 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1947 gggtttctgt gattttcttt tgg 23 <210> 1948 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1948 gggccaaaga cctccgccag tgg 23 <210> 1949 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1949 gttggagaag cattcataaa agg 23 <210> 1950 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1950 gtcgctcact caccctgcaa agg 23 <210> 1951 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1951 gaaaagagct gatgaaacaa tgg 23 <210> 1952 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1952 gtacactttt caaaatgctt tgg 23 <210> 1953 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1953 ggagatgatc atcaagcaga agg 23 <210> 1954 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1954 gctttgaaag agcaataaaa tgg 23 <210> 1955 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1955 gcacaaaagt caaatcggaa tgg 23 <210> 1956 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1956 gatttcaata taagattcgg agg 23 <210> 1957 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1957 gcttaagcaa tcccgaactc tgg 23 <210> 1958 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1958 gccttcttta tcccctatcg 20 <210> 1959 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <220> <221> modified_base <222> (21)..(22) <223> a, c, t, g, unknown or other <400> 1959 gaggccaaac ctcggcttac nngrr 25 <210> 1960 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <220> <221> modified_base <222> (21)..(22) <223> a, c, t, g, unknown or other <400> 1960 gttcgaaaat ttcaggtaag nngrr 25 <210> 1961 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <220> <221> modified_base <222> (21)..(22) <223> a, c, t, g, unknown or other <400> 1961 ggcagaacag gagataacag nngrrt 26 <210> 1962 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1962 ggcggccctc gcccttctct ggggat 26 <210> 1963 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1963 gtagtgatcg tggatacgag agg 23 <210> 1964 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1964 gtacagccct cggtgtatat tgg 23 <210> 1965 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1965 gggaaggaat taagcccgaa tgg 23 <210> 1966 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1966 gggaacagct ttcgtagttg agg 23 <210> 1967 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1967 gataaagtcc agtgtcgatc agg 23 <210> 1968 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1968 gaaaaccaga gcttcggtca agg 23 <210> 1969 <211> 34 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1969 ggagtcttct gggcaggctt aaaggctaac ctgg 34 <210> 1970 <211> 34 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1970 gtcgggtgag catgtcttta atctacctcg atgg 34 <210> 1971 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1971 ggtgtcacca gagtaacagt ctgagt 26 <210> 1972 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1972 gtgatcatca agcagaaggt atgag 25 <210> 1973 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1973 gaacttcgaa aatttcaggt aagccgagg 29 <210> 1974 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1974 ggaaactcat caaatatgcg tgttagtgt 29 <210> 1975 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1975 gtcatttaca ctaacacgca tatttgatg 29 <210> 1976 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1976 ggaatgaaac tcatcaaata tgcgtgtta 29 <210> 1977 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1977 gtcatcaata tctttgaagg actctgggt 29 <210> 1978 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1978 gtgttttcat aggaaaaata ggcaagttg 29 <210> 1979 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1979 gaattggaaa atgtgatggg aaacagata 29 <210> 1980 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1980 gatgatcatc aagcagaagg tatgagaaa 29 <210> 1981 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1981 gagatgatca tcaagcagaa ggtatgaga 29 <210> 1982 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1982 gcattttttc tcataccttc tgcttgatg 29 <210> 1983 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1983 gtcctactca gactgttact ctggtgaca 29 <210> 1984 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1984 gacaggttgt gtcaccagag taacagtct 29 <210> 1985 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1985 gttatcattt tttctcatac cttctgctt 29 <210> 1986 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1986 gttgcctaag aactggtggg aaatggtct 29 <210> 1987 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1987 gaaacagttg cctaagaact ggtgggaaa 29 <210> 1988 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1988 gtttcccacc agttcttagg caactgttt 29 <210> 1989 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1989 gtggctttga tttccctagg gtccagctt 29 <210> 1990 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1990 gtagggaaat caaagccaat gaaacgttc 29 <210> 1991 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1991 ggaccctagg gaaatcaaag ccaatgaaa 29 <210> 1992 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1992 gtgagggctc caccctcacg agtgggttt 29 <210> 1993 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1993 gaaggattga gggctccacc ctcacgagt 29 <210> 1994 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1994 ggctccaccc tcacgagtgg gtttggttc 29 <210> 1995 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1995 gtatccccta tcgaggaaac cacgagttt 29 <210> 1996 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1996 ggataaagaa ggcctatttc atagagttg 29 <210> 1997 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1997 gaggccttct ttatccccta tcgaggaaa 29 <210> 1998 <211> 27 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1998 gtgagggctc caccctcacg agtgggt 27 <210> 1999 <211> 27 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 1999 ggataaagaa ggcctatttc atagagt 27 <210> 2000 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2000 caccgcagcc gctcgctgca gcag 24 <210> 2001 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2001 aaacctgctg cagcgagcgg ctgc 24 <210> 2002 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2002 caccggctgg gtgtcccatt gaaa 24 <210> 2003 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2003 aaactttcaa tgggacaccc agcc 24 <210> 2004 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2004 caccggttta ttcagccggg agtc 24 <210> 2005 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2005 aaacgactcc cggctgaata aacc 24 <210> 2006 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2006 caccgtggag agtttgcaag gagc 24 <210> 2007 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2007 aaacgctcct tgcaaactct ccac 24 <210> 2008 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2008 caccgccctc cagactttcc acct 24 <210> 2009 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2009 aaacaggtgg aaagtctgga gggc 24 <210> 2010 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2010 caccgaattt tcttccaagt tctc 24 <210> 2011 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2011 aaacgagaac ttggaagaaa attc 24 <210> 2012 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2012 caccgctgcg gagagaagaa aggg 24 <210> 2013 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2013 aaaccccttt cttctctccg cagc 24 <210> 2014 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2014 caccgagagc caccccctgg ctcc 24 <210> 2015 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2015 aaacggagcc agggggtggc tctc 24 <210> 2016 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2016 caccgcgaag ccaaccgcgg cggg 24 <210> 2017 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2017 aaaccccgcc gcggttggct tcgc 24 <210> 2018 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2018 caccgagagg gaagacgatc gccc 24 <210> 2019 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2019 aaacgggcga tcgtcttccc tctc 24 <210> 2020 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2020 caccgcccct ttaactttcc tccg 24 <210> 2021 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2021 aaaccggagg aaagttaaag gggc 24 <210> 2022 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2022 caccggcagc cccgcttcct tcaa 24 <210> 2023 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2023 aaacttgaag gaagcggggc tgcc 24 <210> 2024 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2024 caccgcgaga gcgagaggag ggag 24 <210> 2025 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2025 aaacctccct cctctcgctc tcgc 24 <210> 2026 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2026 caccggagag agcttgagag cgcg 24 <210> 2027 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2027 aaaccgcgct ctcaagctct ctcc 24 <210> 2028 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2028 caccgggtgg agggggcggg gccc 24 <210> 2029 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2029 aaacgggccc cgccccctcc accc 24 <210> 2030 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2030 caccgggtat ccacgtaaat caaa 24 <210> 2031 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2031 aaactttgat ttacgtggat accc 24 <210> 2032 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2032 caccgccaat cactggctcc ggtc 24 <210> 2033 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2033 aaacgaccgg agccagtgat tggc 24 <210> 2034 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2034 caccgggcgc ccgagggaag aaga 24 <210> 2035 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2035 aaactcttct tccctcgggc gccc 24 <210> 2036 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2036 caccggggtg ggggtaccag agga 24 <210> 2037 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2037 aaactcctct ggtaccccca cccc 24 <210> 2038 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2038 caccgccggg gacagaagag aggg 24 <210> 2039 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2039 aaacccctct cttctgtccc cggc 24 <210> 2040 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2040 caccggagag agagtgggag aagc 24 <210> 2041 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2041 aaacgcttct cccactctct ctcc 24 <210> 2042 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2042 caccgaaagt aactgtcaaa tgcg 24 <210> 2043 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2043 aaaccgcatt tgacagttac tttc 24 <210> 2044 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2044 caccgttaac cagagcgccc agtc 24 <210> 2045 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2045 aaacgactgg gcgctctggt taac 24 <210> 2046 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2046 caccgcgtcg gagctgcccg ctag 24 <210> 2047 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2047 aaacctagcg ggcagctccg acgc 24 <210> 2048 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2048 tgtactctct gaggtgctc 19 <210> 2049 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2049 acgcagataa gaaccagtt 19 <210> 2050 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2050 catcaagtca gccatcagc 19 <210> 2051 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2051 gagtcaccct cctggaaac 19 <210> 2052 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2052 cctgggctcc ggggcgttt 19 <210> 2053 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2053 ggcccctgcg gccaccccg 19 <210> 2054 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2054 ctccctccct gcccggtag 19 <210> 2055 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2055 aggtttggaa agggcgtgc 19 <210> 2056 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2056 actccactgc actccagtct 20 <210> 2057 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2057 tctgtggggg acctgcactg 20 <210> 2058 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2058 ggggcgccag ttgtgtctcc 20 <210> 2059 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2059 acaccattgc caccaccatt 20 <210> 2060 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2060 caatgacccc ttcattgacc 20 <210> 2061 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2061 ttgattttgg agggatctcg 20 <210> 2062 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2062 ggaatccatg gagggaagat 20 <210> 2063 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2063 tgttctcgct caggtcagtg 20 <210> 2064 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2064 ctctctgctc ctttgccaca 20 <210> 2065 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2065 gtgctcttcg ggtttcagga 20 <210> 2066 <211> 30 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2066 cgaaagagaa agcgaaccag tatcgagaac 30 <210> 2067 <211> 27 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2067 cgttgtgcat agtcgctgct tgatcgc 27 <210> 2068 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2068 uagaagaucu gagcucugag 20 <210> 2069 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2069 agaucugagc ucugagugga 20 <210> 2070 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2070 ucugagcucu gaguggaagg 20 <210> 2071 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2071 ccguuuacuu caagagcuga 20 <210> 2072 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2072 aagcagccug accuagcucc 20 <210> 2073 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2073 gcuccuggac ugaccacuau 20 <210> 2074 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2074 cccucagcuc uugaaguaaa 20 <210> 2075 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2075 gucaguccag gagcuagguc 20 <210> 2076 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2076 uaguggucag uccaggagcu 20 <210> 2077 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2077 gcuccaauag uggucagucc 20 <210> 2078 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2078 uggccaaaga ccuccgccag 20 <210> 2079 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2079 guggcagaca aauguagaug 20 <210> 2080 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2080 uguagaugug gcaaaugacu 20 <210> 2081 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2081 cuuggcccug aaacuucucc 20 <210> 2082 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2082 cagagaauau caaugccucu 20 <210> 2083 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2083 cagagaauau caaugccucu 20 <210> 2084 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2084 cauuugucug ccacuggcgg 20 <210> 2085 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2085 cuacauuugu cugccacugg 20 <210> 2086 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2086 caucuacauu ugucugccac 20 <210> 2087 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2087 auaaucccgg agaaguuuca 20 <210> 2088 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2088 uaucaucugc agaauaaucc 20 <210> 2089 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2089 uguuaucaug uggacuuuuc 20 <210> 2090 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2090 ugauauauca uuucucugug 20 <210> 2091 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2091 uuuaugaaug cuucuccaag 20 <210> 2092 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2092 uucuccaggc uagaagaaca a 21 <210> 2093 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2093 cugcucuuuu ccagguucaa g 21 <210> 2094 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2094 gucuguuuca guuacuggug g 21 <210> 2095 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2095 uccaguuuca uuuaauuguu u 21 <210> 2096 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2096 cuuaugggag cacuuacaag c 21 <210> 2097 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2097 uugcuucauu accuucacug g 21 <210> 2098 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2098 uugugucacc agaguaacag u 21 <210> 2099 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2099 aguaaccaca gguuguguca c 21 <210> 2100 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2100 uucaaauuuu gggcagcggu a 21 <210> 2101 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2101 caagaggcua gaacaaucau u 21 <210> 2102 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2102 uuguacuuca ucccacugau u 21 <210> 2103 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2103 cuucagaacc ggaggcaaca g 21 <210> 2104 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2104 caacaguuga augaaauguu a 21 <210> 2105 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2105 gccaagcuug agucauggaa g 21 <210> 2106 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2106 cuugguuucu gugauuuucu u 21 <210> 2107 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2107 ucauuucaca ggccuucaag a 21 <210> 2108 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2108 cagaaauauu cguacagucu c 21 <210> 2109 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2109 caauuaccuc ugggcuccug g 21 <210> 2110 <211> 19 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2110 gaacuucuau uuaauuuug 19 <210> 2111 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2111 auuucaggua agccgagguu 20 <210> 2112 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2112 ucuuaauaau guuucacugu 20 <210> 2113 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2113 auaauuucua uuauauuaca 20 <210> 2114 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2114 uuucauucau aucaagaaga 20 <210> 2115 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2115 auaguuuaaa ggccaaaccu 20 <210> 2116 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2116 ugugaaaaaa uauaguuuaa 20 <210> 2117 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2117 cgaaaauuuc agguaagccg 20 <210> 2118 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2118 caaaaaccca aaatatttta gct 23 <210> 2119 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2119 cctttttggt atcttacagg aac 23 <210> 2120 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2120 ccgctgccca atgccatcct gga 23 <210> 2121 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2121 tttttccttt tattctagtt gaa 23 <210> 2122 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2122 ttgatccata tgcttttacc tgc 23 <210> 2123 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2123 tcaacagatc tgtcaaatcg cct 23 <210> 2124 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2124 ttcttctttc tccaggctag aag 23 <210> 2125 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2125 gttcttctag cctggagaaa gaa 23 <210> 2126 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2126 caaatcctgc attgttgcct gta 23 <210> 2127 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2127 ctgttaaaga ggaagttaga aga 23 <210> 2128 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2128 aaaattttta tattacagaa tat 23 <210> 2129 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2129 ttgtagacta tcttttatat tct 23 <210> 2130 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2130 ttttgcattt tagatgaaag aga 23 <210> 2131 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2131 aacatcttct ctttcatcta aaa 23 <210> 2132 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2132 ttttgaacat cttctctttc atc 23 <210> 2133 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2133 caaaaaccca aaatatttta gct 23 <210> 2134 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2134 gcttgtgttt ctaatttttc ttt 23 <210> 2135 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2135 acttattgtt attgaaattg gct 23 <210> 2136 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2136 taccatgtat tgctaaacaa agt 23 <210> 2137 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2137 gtatcaattc acaccagcaa gtt 23 <210> 2138 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2138 ctcctctgta aagtggcgat tat 23 <210> 2139 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2139 tttaaaatga agattttcca cca 23 <210> 2140 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2140 aaatgaagat tttccaccaa tca 23 <210> 2141 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2141 ccaccaatca ctttactctc cta 23 <210> 2142 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2142 ccaccagttc ttaggcaact gtt 23 <210> 2143 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2143 cattaattta tatccttgat tat 23 <210> 2144 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2144 gttgttgttg ttaaggtcaa agt 23 <210> 2145 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2145 aaattaccct agatcttaaa gtt 23 <210> 2146 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2146 gcctctgatt agggtggggg cgtg 24 <210> 2147 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2147 tcacaggctc caggaagggt ttgg 24 <210> 2148 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2148 cccagggggg cctctttcgg aagg 24 <210> 2149 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2149 ggaaggctct cttggtgatg gaga 24 <210> 2150 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2150 aagctagtct agtgcaagct aaca 24 <210> 2151 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2151 ctggcctatg ttattacctg tatg 24 <210> 2152 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2152 tggcctatgt tattacctgt atgg 24 <210> 2153 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2153 ttccattcta atgggtggct gtt 23 <210> 2154 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2154 ctcctctgta aagtggcgat 20 <210> 2155 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2155 ttccattcta atgggtggct 20 <210> 2156 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2156 gtatcaattc acaccagcaa 20 <210> 2157 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2157 taccatgtat tgctaaacaa 20 <210> 2158 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2158 acttattgtt attgaaattg 20 <210> 2159 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2159 gcttgtgttt ctaatttttc 20 <210> 2160 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2160 caaaaaccca aaatatttta 20 <210> 2161 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2161 tttaaaatga agattttcca 20 <210> 2162 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2162 aaatgaagat tttccaccaa 20 <210> 2163 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2163 ccaccaatca ctttactctc 20 <210> 2164 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2164 ccaccagttc ttaggcaact 20 <210> 2165 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2165 cattaattta tatccttgat 20 <210> 2166 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2166 agttatagct ctctttcaat 20 <210> 2167 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2167 atgtataaca attccaacat 20 <210> 2168 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2168 aaattaccct agatcttaaa 20 <210> 2169 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2169 gttgttgttg ttaaggtcaa 20 <210> 2170 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2170 gcttgtgttt ctaatttttc 20 <210> 2171 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2171 taatttttct ttttcttctt 20 <210> 2172 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2172 gcaaaaagga aaaaagaaga 20 <210> 2173 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2173 gggtttttgc aaaaaggaaa 20 <210> 2174 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2174 agctcctact cagactgtta 20 <210> 2175 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2175 tgcaaaaacc caaaatattt 20 <210> 2176 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2176 tgtcaccaga gtaacagtct 20 <210> 2177 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2177 cttagtaacc acaggttgtg 20 <210> 2178 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2178 tagtttggag atggcagttt 20 <210> 2179 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2179 gagatggcag tttccttagt 20 <210> 2180 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2180 cttgatgttg gaggtacctg 20 <210> 2181 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2181 atgttggagg tacctgctct 20 <210> 2182 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2182 taacttgatc aagcagagaa 20 <210> 2183 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2183 tctgcttgat caagttataa 20 <210> 2184 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2184 taaaatcaca gagggtgatg 20 <210> 2185 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2185 atatcctcaa ggtcacccac 20 <210> 2186 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2186 atgatcatct cgttgatatc 20 <210> 2187 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2187 tcataccttc tgcttgatga 20 <210> 2188 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2188 tcattttttc tcataccttc 20 <210> 2189 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2189 tgccaacttt tatcattttt 20 <210> 2190 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2190 aatcagaaag aagatcttat 20 <210> 2191 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2191 atttccctag ggtccagctt 20 <210> 2192 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2192 gctcaaattg ttactcttca 20 <210> 2193 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2193 agctcctact cagactgtta 20 <210> 2194 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2194 attctagtac tatgcatctt 20 <210> 2195 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2195 acttaagtta cttgtccagg 20 <210> 2196 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2196 ccaaggtccc agagttccta 20 <210> 2197 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2197 tttccctggc aaggtctgaa 20 <210> 2198 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2198 gctcattctc atgcctggac 20 <210> 2199 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2199 tttagcaata catggtagaa 20 <210> 2200 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2200 agccaaactc ttattcatga 20 <210> 2201 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2201 taacaatgtg gatactttgt 20 <210> 2202 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2202 guguuauuac uugcuacugc a 21 <210> 2203 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2203 guguauugcu uguacuacuc a 21 <210> 2204 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2204 guuuaaaugu aaauagcuca g 21 <210> 2205 <211> 22 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2205 gaauuuucaa ugauguucug gg 22 <210> 2206 <211> 22 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2206 gaacuggugg gaaauggucu ag 22 <210> 2207 <211> 22 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2207 guuucauugg cuuugauuuc cc 22 <210> 2208 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2208 ggcaauucuc cugaauagaa a 21 <210> 2209 <211> 22 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2209 gauuauacuu aggcugaaua gu 22 <210> 2210 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2210 gacuuccaga auuauguguu c 21 <210> 2211 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2211 gugagggccu gacacauggu a 21 <210> 2212 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2212 gugaagauca uuucuuggua g 21 <210> 2213 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2213 gcacagucag aacuagugug c 21 <210> 2214 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2214 gaguaagccc gaucauuauu g 21 <210> 2215 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2215 ggaagggaca uauucuaugg g 21 <210> 2216 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2216 gaccacaagc ugacuugggg g 21 <210> 2217 <211> 21 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2217 ggauuuguau ccauuaucug g 21 <210> 2218 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2218 cucugcauug uuuuggccuc 20 <210> 2219 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2219 uccuccaaag aguagaaugg 20 <210> 2220 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2220 gcccuaaacu uacacuguuc 20 <210> 2221 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2221 aaagauagau uagauugucc 20 <210> 2222 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2222 guugcuaaau uacauaguuu 20 <210> 2223 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2223 uguugcaaua gucaaucaag 20 <210> 2224 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2224 auacugauua agacagauga 20 <210> 2225 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2225 aauacugauu aagacagaug 20 <210> 2226 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2226 cucuauacaa augccaacgc 20 <210> 2227 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2227 acuugcaugc acaccagcgu 20 <210> 2228 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2228 uugggcuaau guagcauaau 20 <210> 2229 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2229 gcguuggcau uuguauagag 20 <210> 2230 <211> 19 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2230 ugggcuaagu agcauaaug 19 <210> 2231 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2231 uuugggcuaa uguagcauaa 20 <210> 2232 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2232 gcuuaacucc uuaauauuaa 20 <210> 2233 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2233 ucuucuauau uaaagcagau 20 <210> 2234 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2234 cuucuauauu aaagcagauu 20 <210> 2235 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2235 aauauauaac uaccuugggu 20 <210> 2236 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2236 accuccauuc uacucuuugg 20 <210> 2237 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2237 uuucaaugau auccaaccca 20 <210> 2238 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2238 aguaccucca uucuacucuu 20 <210> 2239 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2239 cuauccucca aagaguagaa 20 <210> 2240 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2240 uuuugcuaca uauuucaggc 20 <210> 2241 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2241 uuugcuacau auuucaggcu 20 <210> 2242 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2242 ggguuggaua ucauugaaaa 20 <210> 2243 <211> 19 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2243 auauuucagg cuggguucu 19 <210> 2244 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2244 uugaaauaua uaacuaccuu 20 <210> 2245 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2245 auugaaauau auaacuaccu 20 <210> 2246 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2246 gugaguagug gggcacuuua 20 <210> 2247 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2247 uguauguaga agguuaacua 20 <210> 2248 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2248 gagccuaaua aauguacaau 20 <210> 2249 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2249 uuguauguag aagguuaacu 20 <210> 2250 <211> 19 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2250 caauuuguuu ugaguaacu 19 <210> 2251 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2251 ugccuucuga aauaguccag 20 <210> 2252 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2252 guuaauaggg aaacagcaua 20 <210> 2253 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2253 aacaaugcag aguuaauugu 20 <210> 2254 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2254 gaacauguug aguagacaca 20 <210> 2255 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2255 uuuaucaucu gugucuauuc 20 <210> 2256 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2256 ucuuuacuuu cuugacuaua 20 <210> 2257 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2257 aauauucuca aaccucguuc 20 <210> 2258 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2258 auuaacugug uuccagaacg 20 <210> 2259 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2259 uaacugcuuc uuuggaugac 20 <210> 2260 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2260 gaccagaaca guguaaguuu 20 <210> 2261 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2261 accagaacag uguaaguuua 20 <210> 2262 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2262 cuacuuuuuc cccacuacug 20 <210> 2263 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2263 uggaacacag uuaauucacu 20 <210> 2264 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2264 guguuguuua acugcuucuu 20 <210> 2265 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2265 aacugucagu ugcauauucc 20 <210> 2266 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2266 cagaaaggaa ugcugguacc 20 <210> 2267 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2267 ucugccuaca caaugaaugg 20 <210> 2268 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2268 cacagaucaa uccaauuguu 20 <210> 2269 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2269 uugacaggug gaaaguacau 20 <210> 2270 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2270 acauuuuuag gcuugacagg 20 <210> 2271 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2271 cucucccaug acagacuccc 20 <210> 2272 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2272 uugguaagag uuaugauaag 20 <210> 2273 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2273 aacacaaauu aaguucaccu 20 <210> 2274 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2274 aggaucagug cuguagugcc 20 <210> 2275 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2275 ggccguuuau uauuauugac 20 <210> 2276 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2276 ucucaggauu gcuaugcaac 20 <210> 2277 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2277 caggaagaca uaccauguaa 20 <210> 2278 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2278 agcagggcuc uuucaguuuc 20 <210> 2279 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2279 uaacauuuuc agcuugaacc 20 <210> 2280 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2280 ucaagcugaa aauguuacac 20 <210> 2281 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2281 guaacauuuu cagcuugaac 20 <210> 2282 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2282 cagaaugaau uuuggagcac 20 <210> 2283 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2283 uuuauuauua uugacuggug 20 <210> 2284 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2284 agaagaaucu gaccuuuaca 20 <210> 2285 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2285 gcagggcucu uucaguuucu 20 <210> 2286 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2286 cuaaacagua gccaggcgug 20 <210> 2287 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2287 cgccuggcua cuguuuagug 20 <210> 2288 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2288 cuccgcacua aacaguagcc 20 <210> 2289 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2289 guagccaggc guguggaugu 20 <210> 2290 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2290 cuuggcuuug acuauucugc 20 <210> 2291 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2291 aguagccagg cguguggaug 20 <210> 2292 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2292 uccucccaca uccacacgcc 20 <210> 2293 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2293 uuggcuuuga cuauucugcu 20 <210> 2294 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2294 auaaugucuc uggcuuguaa 20 <210> 2295 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2295 ugguacccgg cagcucucug 20 <210> 2296 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2296 gugggaggaa ccucaaagag 20 <210> 2297 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2297 ugacuauucu gcugggaaca 20 <210> 2298 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2298 cucucugagg aauguucccu 20 <210> 2299 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2299 aacauuccuc agagagcugc 20 <210> 2300 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2300 auucugaagc uccaaacaau 20 <210> 2301 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2301 uaaauuacuc ugcuaaagua 20 <210> 2302 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2302 aguacaaacc agguuuguac 20 <210> 2303 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2303 auauccuucc aguacaaacc 20 <210> 2304 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2304 caaaccaggu uuguacugga 20 <210> 2305 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2305 ggcagcuaaa gcaucacuga 20 <210> 2306 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2306 aucucugagu aguacaaacc 20 <210> 2307 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2307 gugucccauu cucuuugacu 20 <210> 2308 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2308 ugugucccau ucucuuugac 20 <210> 2309 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2309 uucugaaugu ugaacaagua 20 <210> 2310 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2310 gucucccagu caaagagaau 20 <210> 2311 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2311 auucucuuug acugggagac 20 <210> 2312 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2312 ucuuugacug ggagacaggc 20 <210> 2313 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2313 gugguguccu uugaauaugc 20 <210> 2314 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2314 agauugucca ggauauaauu 20 <210> 2315 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2315 uuagcaacca aauuauaucc 20 <210> 2316 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2316 guugaaauua aacuacacac 20 <210> 2317 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2317 aucuuuaccu gcauauucaa 20 <210> 2318 <211> 17 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2318 guguccuuug aauaugc 17 <210> 2319 <211> 17 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2319 uuguccagga uauaauu 17 <210> 2320 <211> 17 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2320 gcaaccaaau uauaucc 17 <210> 2321 <211> 17 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2321 gaaauuaaac uacacac 17 <210> 2322 <211> 17 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2322 uuuaccugca uauucaa 17 <210> 2323 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2323 uacacauuuu uaggcuugac 20 <210> 2324 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2324 cauuccuggg agucugucau 20 <210> 2325 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2325 uguaugaugc uauaauacca 20 <210> 2326 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2326 guggaaagua cauaggaccu 20 <210> 2327 <211> 20 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2327 ucuuaucaua acucuuacca 20 <210> 2328 <211> 17 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2328 acauuuuuag gcuugac 17 <210> 2329 <211> 17 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2329 uccugggagu cugucau 17 <210> 2330 <211> 17 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2330 augaugcuau aauacca 17 <210> 2331 <211> 17 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2331 gaaaguacau aggaccu 17 <210> 2332 <211> 17 <212> RNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2332 uaucauaacu cuuacca 17 <210> 2333 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2333 gagttcctac tcagactgtt actc 24 <210> 2334 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2334 gtgagttcct actcagactg ttactc 26 <210> 2335 <211> 28 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2335 gtctgagttc ctactcagac tgttactc 28 <210> 2336 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2336 aaagatatat aatgtcatga at 22 <210> 2337 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2337 gcagaatcaa atataatagt ct 22 <210> 2338 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2338 aacaaatatc ccttagtatc 20 <210> 2339 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2339 aatgtatttc ttctattcaa 20 <210> 2340 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2340 aacaataagt caaatttaat tg 22 <210> 2341 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2341 gaactggtgg gaaatggtct ag 22 <210> 2342 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2342 tcctttggta aataaaagtc ct 22 <210> 2343 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2343 taggaatcaa atggacttgg at 22 <210> 2344 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2344 taattctttc tagaaagagc ct 22 <210> 2345 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2345 ctcttgcatc ttgcacatgt cc 22 <210> 2346 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2346 acttagaggt cttctacata ca 22 <210> 2347 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2347 tcagaggtga gtggtgaggg ga 22 <210> 2348 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2348 acacacagct gggttatcag ag 22 <210> 2349 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2349 cacagctggg ttatcagag 19 <210> 2350 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2350 acacagctgg gttatcagag 20 <210> 2351 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2351 cacacagctg ggttatcaga g 21 <210> 2352 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2352 aacacacagc tgggttatca gag 23 <210> 2353 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2353 ctgstgggar atggtctag 19 <210> 2354 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2354 actggtggga aatggtctag 20 <210> 2355 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2355 aactggtggg aaatggtcta g 21 <210> 2356 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2356 agaactggtg ggaaatggtc tag 23 <210> 2357 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2357 atatcttctt aaatacccga 20 <210> 2358 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2358 agtctcacaa aactgcagag 20 <210> 2359 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2359 tacttatgta ttttaaaaac 20 <210> 2360 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2360 gaataatttc tattatatta ca 22 <210> 2361 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2361 ttcgaaaatt tcaggtaagc cg 22 <210> 2362 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2362 tcatttctaa aagtcttttg cc 22 <210> 2363 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2363 tttgagacac agtataggtt at 22 <210> 2364 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2364 atataataga aattattcat 20 <210> 2365 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2365 taatatgccc tgtaatataa 20 <210> 2366 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2366 tgatatcatc aatatctttg 20 <210> 2367 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2367 gcaattaatt ggaaaatgtg 20 <210> 2368 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2368 ctttaagctt aggtaaaatc a 21 <210> 2369 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2369 cagtaatgtg tcataccttc 20 <210> 2370 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2370 cagggcatat tatatttaga 20 <210> 2371 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2371 caaaagccaa atctatttca 20 <210> 2372 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2372 atgctttggt gggaagaagt agagga 26 <210> 2373 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2373 atgctttggt gggaagaata gaggac 26 <210> 2374 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2374 ttgtgacaag ctcactaatt agg 23 <210> 2375 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2375 aagtttgaag aacttttacc agg 23 <210> 2376 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2376 aggcagcgat aaaaaaaacc tgg 23 <210> 2377 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2377 gctttggtgg gaagaagtag agg 23 <210> 2378 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2378 tgcaaaaacc caaaatattt tag 23 <210> 2379 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2379 aaaatatttt agctcctact cag 23 <210> 2380 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2380 cagagtaaca gtctgagtag gag 23 <210> 2381 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2381 ttgccttttt ggtatcttac agg 23 <210> 2382 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2382 tttgcctttt tggtatctta cag 23 <210> 2383 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2383 cgctgcccaa tgccatcctg gag 23 <210> 2384 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2384 atttattttt cctttattct ag 22 <210> 2385 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2385 tttcctttta ttctagttga aag 23 <210> 2386 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2386 tgattctgaa ttctttcaac tag 23 <210> 2387 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2387 atccatatgc ttttacctgc agg 23 <210> 2388 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2388 gatccatatg cttttacctg cag 23 <210> 2389 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2389 cagatctgtc aaatcgcctg cag 23 <210> 2390 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2390 ttattcttct ttctccaggc tag 23 <210> 2391 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2391 aattttattc ttctttctcc agg 23 <210> 2392 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2392 caattttatt cttctttctc cag 23 <210> 2393 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2393 taagggatat ttgttcttac agg 23 <210> 2394 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2394 ctaagggata tttgttctta cag 23 <210> 2395 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2395 tgttcttaca ggcaacaatg cag 23 <210> 2396 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2396 tgtatgcttt tctgttaaag agg 23 <210> 2397 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2397 atgtgtatgc ttttctgtta aag 23 <210> 2398 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2398 gtgtatgctt ttctgttaaa gag 23 <210> 2399 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2399 gttttaaaat ttttatatta cag 23 <210> 2400 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2400 ttttatatta cagaatataa aag 23 <210> 2401 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2401 atattacaga atataaaaga tag 23 <210> 2402 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2402 tgaaaattta tttccacatg tag 23 <210> 2403 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2403 gaaaatttat ttccacatgt agg 23 <210> 2404 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2404 ttacattttt gacctacatg tgg 23 <210> 2405 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2405 tgtgtatgtg tatgtgtttt agg 23 <210> 2406 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2406 tatgtgtatg tgttttaggc cag 23 <210> 2407 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2407 ctattccagt caaataggtc tgg 23 <210> 2408 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2408 gtgtagtgtt aatgtgctta cag 23 <210> 2409 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2409 ggacttctta tctggatagg tgg 23 <210> 2410 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2410 taggtggtat caacatctgt aag 23 <210> 2411 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2411 tgaacatttg gtcctttgca ggg 23 <210> 2412 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2412 tctgaacatt tggtcctttg cag 23 <210> 2413 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2413 tctcgctcac tcaccctgca aag 23 <210> 2414 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2414 aaagaaaatc acagaaacca agg 23 <210> 2415 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2415 aaaatcacag aaaccaaggt tag 23 <210> 2416 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2416 ggtatctttg atactaacct tgg 23 <210> 2417 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2417 gtaatacaaa tggtatctta agg 23 <210> 2418 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2418 tatgtgttac ctacccttgt cgg 23 <210> 2419 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2419 aaatgtacaa ggaccgacaa ggg 23 <210> 2420 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2420 gtacaaggac cgacaagggt agg 23 <210> 2421 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2421 atgctctcat ccatagtcat agg 23 <210> 2422 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2422 tctcatccat agtcataggt aag 23 <210> 2423 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2423 catccatagt cataggtaag aag 23 <210> 2424 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2424 tgcactattc tcaacaggta aag 23 <210> 2425 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2425 tcaaatgcac tattctcaac agg 23 <210> 2426 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2426 ctttacacac tttacctgtt gag 23 <210> 2427 <211> 18 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2427 ttccctggca aggtctga 18 <210> 2428 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2428 atcctcaagg tcacccacc 19 <210> 2429 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2429 gtctttctgt cttgtatcct ttgg 24 <210> 2430 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2430 aatgttagtg cctttcaccc 20 <210> 2431 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2431 gggaaatcag gctgatgggt 20 <210> 2432 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2432 gtctactgtt catttcagc 19 <210> 2433 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2433 gcaggaaact atcagagtg 19 <210> 2434 <211> 18 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2434 acaccttgct gttacgat 18 <210> 2435 <211> 18 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2435 ccaccaaacc tggcaaat 18 <210> 2436 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2436 gaactatgaa taacctaatg ggcag 25 <210> 2437 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2437 ttcttactca aggcattcag ac 22 <210> 2438 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2438 ggtcaccaca cccatcaat 19 <210> 2439 <211> 18 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2439 tgcctggaga aagggttt 18 <210> 2440 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2440 gcacagtcaa taacacaaag gt 22 <210> 2441 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2441 agcgatccac tctctcagga tg 22 <210> 2442 <211> 28 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2442 gcacctcaat gccccaatct gatttacg 28 <210> 2443 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2443 gggtctaata tggcagaatc ca 22 <210> 2444 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2444 gttgtaaagt aggacatgat ctgg 24 <210> 2445 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2445 aggactatgg gcattggtt 19 <210> 2446 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2446 gtgtagaaat gacaagtctc agatg 25 <210> 2447 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2447 gaaagctact ctgttagatg ggctag 26 <210> 2448 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2448 ggctttgtat atatacacgt g 21 <210> 2449 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2449 gcagcatcaa agacaagca 19 <210> 2450 <211> 18 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2450 tccttacggg tagcatcc 18 <210> 2451 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2451 cccagaagag caagataaac ttgaa 25 <210> 2452 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2452 ctctgttcca aatcctgcat tgt 23 <210> 2453 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2453 caagaccagc aatcaagagg ctag 24 <210> 2454 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2454 tcatgtggac ttttctggta tcatc 25 <210> 2455 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2455 gaactccagg atggcattgg 20 <210> 2456 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2456 ctctgttcca aatcctgcat tgt 23 <210> 2457 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2457 gaaactgcca tctccaaact agaaa 25 <210> 2458 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2458 ttctccaaga ggcattgata ttctc 25 <210> 2459 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2459 cccagaagag caagataaac ttgaa 25 <210> 2460 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2460 ctctgttcca aatcctgcat tgt 23 <210> 2461 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2461 caagaccagc aatcaagagg ctag 24 <210> 2462 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2462 gagagacttt ttccgaagtt cac 23 <210> 2463 <211> 18 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2463 ttccctggca aggtctga 18 <210> 2464 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2464 atcctcaagg tcacccacc 19 <210> 2465 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2465 cacacctgtt atatttttcc gtgaag 26 <210> 2466 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2466 caaaggagaa gcaaaaacac attcta 26 <210> 2467 <211> 31 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2467 gtaatgtata actgtataac gtggggcact c 31 <210> 2468 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2468 ggtgagttgt tgctacagct cttcc 25 <210> 2469 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2469 cccagaagag caagataaac ttgaa 25 <210> 2470 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2470 ctctgttcca aatcctgcat tgt 23 <210> 2471 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2471 cataagccca gaagagcaag ataaa 25 <210> 2472 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2472 ataggagata accacagcag cagat 25 <210> 2473 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2473 gggaaaaatt gaacctgcac 20 <210> 2474 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2474 catcagctct tttactccct t 21 <210> 2475 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic primer" <400> 2475 ggagggtccc tatacagtag 20 <210> 2476 <211> 11 <212> PRT <213> Homo sapiens <400> 2476 Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr 1 5 10 <210> 2477 <211> 7 <212> PRT <213> Homo sapiens <400> 2477 Met Ser Glu Val Ser Ser Asp 1 5 <210> 2478 <211> 16 <212> PRT <213> Homo sapiens <400> 2478 Met Thr Glu Ile Ile Leu Leu Ile Phe Phe Pro Ala Tyr Phe Leu Asn 1 5 10 15 <210> 2479 <211> 13 <212> PRT <213> Homo sapiens <400> 2479 Met Ser Ala Arg Lys Leu Arg Asn Leu Ser Tyr Lys Lys 1 5 10 <210> 2480 <211> 10 <212> PRT <213> Homo sapiens <400> 2480 Met Leu His Arg Lys Thr Tyr His Val Lys 1 5 10 <210> 2481 <211> 21 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2481 atattttagc tcctactcag a 21 <210> 2482 <211> 11 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2482 ccccacaggt c 11 <210> 2483 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2483 ctggctccac ccttgacctg 20 <210> 2484 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2484 tgaattatgg taatccccac 20 <210> 2485 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2485 ttgtctttga tgctgctctg 20 <210> 2486 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2486 atcaaagaca agcatggtac 20 <210> 2487 <211> 20 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2487 gaaacctcct ctgtggagag 20 <210> 2488 <211> 40 <212> DNA <213> Homo sapiens <400> 2488 aaaaacccaa aatattttag ctcctactca gactgttact 40 <210> 2489 <211> 19 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2489 aaaaacccaa aatattact 19 <210> 2490 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2490 aaaaacccaa aatattttag ctccta 26 <210> 2491 <211> 36 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2491 aaaaacccaa aatattttag ctcctagact gttact 36 <210> 2492 <211> 37 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2492 aaaaacccaa aatattttag ctcctcagac tgttact 37 <210> 2493 <211> 40 <212> DNA <213> Homo sapiens <400> 2493 gcctttttgg tatcttacag gaactccagg atggcattgg 40 <210> 2494 <211> 16 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2494 gcctttttgg cattgg 16 <210> 2495 <211> 26 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2495 gcctttttgg tatcttacag gaatgg 26 <210> 2496 <211> 32 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2496 gcctttttgg tatcttacag gaactgcatt gg 32 <210> 2497 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2497 gcctttttgg tatcttacag gaact 25 <210> 2498 <211> 40 <212> DNA <213> Homo sapiens <400> 2498 agaaaatcac agaaaccaag gttagtatca aagatacctt 40 <210> 2499 <211> 38 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2499 agaaaatcac agaaaccaat tagtatcaaa gatacctt 38 <210> 2500 <211> 35 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2500 agaaaatcac agaaacttag tatcaaagat acctt 35 <210> 2501 <211> 28 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2501 agaaaatcac agaaaccaaa gatacctt 28 <210> 2502 <211> 31 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2502 agaaaatcac agaaaccaag gaagatacct t 31 <210> 2503 <211> 40 <212> DNA <213> Homo sapiens <400> 2503 ccatatgctt ttacctgcag gcgatttgac agatctgttg 40 <210> 2504 <211> 33 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2504 ccatatgctt ttaccgattt gacagatctg ttg 33 <210> 2505 <211> 32 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2505 ccatacctgc aggcgatttg acagatctgt tg 32 <210> 2506 <211> 32 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2506 ccatatctgc aggcgatttg acagatctgt tg 32 <210> 2507 <211> 39 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2507 ccatatgctt ttactgcagg cgatttgaca gatctgttg 39 <210> 2508 <211> 40 <212> DNA <213> Homo sapiens <400> 2508 ttttattctt ctttctccag gctagaagaa caaaagaata 40 <210> 2509 <211> 10 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2509 ttttattctt 10 <210> 2510 <211> 23 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2510 caggctagaa gaacaaaaga ata 23 <210> 2511 <211> 31 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2511 ttttattcca ggctagaaga acaaaagaat a 31 <210> 2512 <211> 40 <212> DNA <213> Homo sapiens <400> 2512 agggatattt gttcttacag gcaacaatgc aggatttgga 40 <210> 2513 <211> 22 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2513 aggcaacaat gcaggatttg ga 22 <210> 2514 <211> 31 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2514 agggatattt gttcacaatg caggatttgg a 31 <210> 2515 <211> 30 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2515 agggatacag gcaacaatgc aggatttgga 30 <210> 2516 <211> 28 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2516 agggataggc aacaatgcag gatttgga 28 <210> 2517 <211> 40 <212> DNA <213> Homo sapiens <400> 2517 tgtatgcttt tctgttaaag aggaagttag aagatctgag 40 <210> 2518 <211> 34 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2518 tgtatgcttt tctgtggaag ttagaagatc tgag 34 <210> 2519 <211> 38 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2519 tgtatgcttt tctgttagag gaagttagaa gatctgag 38 <210> 2520 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2520 tgtatgcttt tctgttaaga agatctgag 29 <210> 2521 <211> 28 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2521 tgtatgcttt tctgttagaa gatctgag 28 <210> 2522 <211> 40 <212> DNA <213> Homo sapiens <400> 2522 atgtacaagg accgacaagg gtaggtaaca catatatttt 40 <210> 2523 <211> 30 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2523 atgtacaagg accgacaaca catatatttt 30 <210> 2524 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2524 atgtacaagg accgacaata tttt 24 <210> 2525 <211> 39 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2525 atgtacaagg accgacaggg taggtaacac atatatttt 39 <210> 2526 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2526 atgtacaagg taggtaacac atatatttt 29 <210> 2527 <211> 40 <212> DNA <213> Homo sapiens <400> 2527 gctctcatcc atagtcatag gtaagaagat tactgagaca 40 <210> 2528 <211> 34 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2528 gctctcatcc ataggtaaga agattactga gaca 34 <210> 2529 <211> 34 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2529 gctctcatcc ataggtaaga agattactga gaca 34 <210> 2530 <211> 34 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2530 gctctcatcc ataggtaaga agattactga gaca 34 <210> 2531 <211> 34 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2531 gctctcatcc ataggtaaga agattactga gaca 34 <210> 2532 <211> 40 <212> DNA <213> Homo sapiens <400> 2532 tgtatgtgta tgtgttttag gccagaccta tttgactgga 40 <210> 2533 <211> 12 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2533 tgtatgtgtg ga 12 <210> 2534 <211> 35 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2534 tgtatgtgta tgtgttttag gcctatttga ctgga 35 <210> 2535 <211> 38 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2535 tgtatgtgta tgtgttttag gccagacatt tgactgga 38 <210> 2536 <211> 39 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2536 tgtatgtgta tgtgttttag gccagactat ttgactgga 39 <210> 2537 <211> 40 <212> DNA <213> Homo sapiens <400> 2537 aaatgcacta ttctcaacag gtaaagtgtg taaaggacag 40 <210> 2538 <211> 40 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2538 aaatgcacta ttctttacac ataaagtgtg taaaggacag 40 <210> 2539 <211> 37 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2539 aaatgcacta ttctcaggta aagtgtgtaa aggacag 37 <210> 2540 <211> 38 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2540 aaatgcacta ttctccaggt aaagtgtgta aaggacag 38 <210> 2541 <211> 38 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2541 aaatgcacta ttcaacaggt aaagtgtgta aaggacag 38 <210> 2542 <211> 40 <212> DNA <213> Homo sapiens <400> 2542 gaacatttgg tcctttgcag ggtgagtgag cgagaggctg 40 <210> 2543 <211> 28 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2543 gaacatttgg tgagtgagcg agaggctg 28 <210> 2544 <211> 17 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2544 gaacatttgg tcctttg 17 <210> 2545 <211> 14 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2545 tgagcgagag gctg 14 <210> 2546 <211> 35 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2546 gaacatttgg tcctttgcaa gtgagcgaga ggctg 35 <210> 2547 <211> 12 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2547 gagcctgcaa ca 12 <210> 2548 <211> 12 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2548 atcgaacagt tg 12 <210> 2549 <211> 12 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2549 aaagagttac tg 12 <210> 2550 <211> 12 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2550 cagaagttga aa 12 <210> 2551 <211> 12 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2551 gtgaagctcc ta 12 <210> 2552 <211> 12 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2552 taaaaggacc tc 12 <210> 2553 <211> 40 <212> DNA <213> Homo sapiens <400> 2553 aaaaacccaa aatattttag ctcctactca gactgttact 40 <210> 2554 <211> 33 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2554 aaaaacccaa aatattttac tcagactgtt act 33 <210> 2555 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2555 aaaaacccaa aatattttag ctcctaact 29 <210> 2556 <211> 30 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2556 aaaaacccaa aatattttca gactgttact 30 <210> 2557 <211> 36 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2557 aaaaacccaa aatattttag ctcctagact gttact 36 <210> 2558 <211> 34 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2558 aaaaacccaa aatattttag ctcagactgt tact 34 <210> 2559 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2559 aaaaacccaa aatatttcag actgttact 29 <210> 2560 <211> 31 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2560 aaaaacccaa aatatttctc agactgttac t 31 <210> 2561 <211> 29 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2561 aaaaacccaa aatattttag actgttact 29 <210> 2562 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2562 cagtggataa aggcaacaat gcag 24 <210> 2563 <211> 38 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2563 aattatggta atccccacag gtcaagggtg gagccagg 38 <210> 2564 <211> 27 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2564 aattatggta atccccacag agccagg 27 <210> 2565 <211> 36 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2565 aattatggta atccccacag caagggtgga gccagg 36 <210> 2566 <211> 35 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2566 aattatggta atcacaggtc aagggtggag ccagg 35 <210> 2567 <211> 25 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2567 aattatggtc aagggtggag ccagg 25 <210> 2568 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2568 cagtggataa aggtcaaggg tgga 24 <210> 2569 <211> 24 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic oligonucleotide" <400> 2569 cagtggataa aggtttccag agct 24

Claims (49)

  1. 심근세포를,
    Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및
    gRNA, 또는 gRNA를 코딩하는 서열과 접촉시키는 단계를 포함하고, 여기서, gRNA는 디스트로핀 유전자의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하는 것인, 심근세포에서 돌연변이체 디스트로핀 유전자를 편집하는 방법.
  2. 제1항에 있어서, gRNA가 엑손 51, 45, 53, 44, 46, 52, 50, 43, 6, 7, 8, 또는 55의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하는 것인 방법.
  3. 제1항 또는 제2항에 있어서, gRNA가 서열번호: 60 내지 705, 712 내지 862, 947 내지 2377 중 어느 하나의 서열을 포함하거나, 또는 그를 표적화하는 것인 방법.
  4. 제1항 내지 제3항 중 어느 한 항에 있어서, 벡터가 gRNA, 또는 gRNA를 코딩하는 서열을 포함하는 것인 방법.
  5. 제4항에 있어서, 벡터가 바이러스 벡터 또는 비-바이러스 벡터인 것인 방법.
  6. 제5항에 있어서, 바이러스 벡터가 아데노-연관 바이러스 (AAV) 벡터인 것인 방법.
  7. 제6항에 있어서, AAV 벡터가 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 및 양 AAV로부터 선택되는 것인 방법.
  8. 제5항에 있어서, 비-바이러스 벡터가 플라스미드인 것인 방법.
  9. 제5항에 있어서, 비-바이러스 벡터가 나노입자인 것인 방법.
  10. 제1항 내지 제9항 중 어느 한 항에 있어서, 제1 벡터가 gRNA, 또는 gRNA를 포함하는 서열을 포함하고, 제2 벡터가 Cas9, 또는 Cas9를 포함하는 서열을 포함하는 것인 방법.
  11. 제10항에 있어서, 제1 벡터 및 제2 벡터가 AAV인 것인 방법.
  12. 제1항 내지 제11항 중 어느 한 항에 있어서, 돌연변이체 디스트로핀 유전자가 점 돌연변이를 포함하는 것인 방법.
  13. 제12항에 있어서, 점 돌연변이가 슈도-엑손 돌연변이인 것인 방법.
  14. 제1항 내지 제13항 중 어느 한 항에 있어서, 돌연변이체 디스트로핀 유전자가 결실을 포함하는 것인 방법.
  15. 제1항 내지 제14항 중 어느 한 항에 있어서, 돌연변이체 디스트로핀 유전자가 중복 돌연변이를 포함하는 것인 방법.
  16. 제1항 내지 제15항 중 어느 한 항에 있어서, Cas9 뉴클레아제가 스트렙토코쿠스 피오게네스(Streptococcus pyogenes)로부터 단리 또는 유래된 것 (spCas9)인 방법.
  17. 제1항 내지 제15항 중 어느 한 항에 있어서, Cas9 뉴클레아제가 스타필로코쿠스 아우레우스(Staphylococcus aureus)로부터 단리 또는 유래된 것 (saCas9)인 방법.
  18. 제1항 내지 제17항 중 어느 한 항의 방법에 따라 제조된 심근세포로서, 여기서, 심근세포는 디스트로핀 단백질을 발현하는 것인 심근세포.
  19. 제18항에 있어서, 심근세포가 유도 만능성 줄기 세포 (iPSc)로부터 유래된 것인 심근세포.
  20. 치료 유효량의, 제18항 또는 제19항의 심근세포를 포함하는 조성물.
  21. 뒤센 근 이영양증(Duchenne muscular dystrophy: DMD)의 치료 또는 예방을 필요로 하는 대상체에게 치료 유효량의, 제20항의 조성물을 투여하는 단계를 포함하는, DMD 치료 또는 예방을 필요로 하는 대상체에서 DMD를 치료 또는 예방하는 방법.
  22. 제21항에 있어서, 치료 유효량이 환자에서 적어도 부분적으로 또는 완전히 심수축성을 회복시키는 것인 방법.
  23. Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및
    gRNA, 또는 gRNA를 코딩하는 서열을 포함하는 유도 만능성 줄기 세포 (iPSc)로서,
    여기서, gRNA는 디스트로핀 유전자의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하는 것인 iPSC.
  24. 제23항의 iPSC로부터 유래된 심근세포를 포함하는 조성물.
  25. 뒤센 근 이영양증 (DMD)의 치료 또는 예방을 필요로 하는 대상체에게 치료 유효량의, 제24항의 조성물을 투여하는 단계를 포함하는, DMD 치료 또는 예방을 필요로 하는 대상체에서 DMD를 치료 또는 예방하는 방법.
  26. 제25항에 있어서, 치료 유효량이 환자에서 적어도 부분적으로 또는 완전히 심수축성을 회복시키는 것인 방법.
  27. 뒤센 근 이영양증 (Duchenne muscular dystrophy: DMD)의 치료 또는 예방을 필요로 하는 대상체에서 DMD를 치료 또는 예방하는 방법으로서,
    대상체에게
    Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및
    gRNA, 또는 gRNA를 코딩하는 서열을 투여하는 단계를 포함하고, 여기서, gRNA는 디스트로핀 유전자의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하고;
    여기서, 투여는 대상체의 심근세포의 적어도 10%에서 디스트로핀 발현을 회복시키는 것인, 방법.
  28. 제27항에 있어서, gRNA가 엑손 51, 45, 53, 44, 46, 52, 50, 43, 6, 7, 8, 또는 55의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하는 것인 방법.
  29. 제27항 또는 제28항에 있어서, gRNA가 서열번호: 60 내지 705, 712 내지 862, 또는 947 내지 2377 중 어느 하나의 서열을 포함하거나, 또는 그를 표적화하는 것인 방법.
  30. 제27항 내지 제29항 중 어느 한 항에 있어서, 벡터가 gRNA, 또는 gRNA를 코딩하는 서열을 포함하는 것인 방법.
  31. 제30항에 있어서, 벡터가 바이러스 벡터 또는 비-바이러스 벡터인 것인 방법.
  32. 제31항에 있어서, 바이러스 벡터가 아데노-연관 바이러스 (AAV) 벡터인 것인 방법.
  33. 제32항에 있어서, AAV 벡터가 AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAVRh74, AAV2i8, AAVRh10, AAV39, AAV43, AAVRh8, 조류 AAV, 소 AAV, 개 AAV, 말 AAV, 및 양 AAV로부터 선택되는 것인 방법.
  34. 제31항에 있어서, 비-바이러스 벡터가 플라스미드인 것인 방법.
  35. 제31항에 있어서, 비-바이러스 벡터가 나노입자인 것인 방법.
  36. 제27항 내지 제35항 중 어느 한 항에 있어서, 제1 벡터가 gRNA, 또는 gRNA를 코딩하는 서열을 포함하고, 제2 벡터가 Cas9, 또는 Cas9를 코딩하는 서열을 포함하는 것인 방법.
  37. 제36항에 있어서, 제1 벡터 및 제2 벡터가 AAV인 것인 방법.
  38. 제27항 내지 제37항 중 어느 한 항에 있어서, 돌연변이체 디스트로핀 유전자가 점 돌연변이를 포함하는 것인 방법.
  39. 제38항에 있어서, 점 돌연변이가 슈도-엑손 돌연변이인 것인 방법.
  40. 제27항 내지 제39항 중 어느 한 항에 있어서, 돌연변이체 디스트로핀 유전자가 결실을 포함하는 것인 방법.
  41. 제27항 내지 제40항 중 어느 한 항에 있어서, 돌연변이체 디스트로핀 유전자가 중복 돌연변이를 포함하는 것인 방법.
  42. 제27항 내지 제41항 중 어느 한 항에 있어서, Cas9 뉴클레아제가 스트렙토코쿠스 피오게네스로부터 단리 또는 유래된 것 (spCas9)인 방법.
  43. 제27항 내지 제42항 중 어느 한 항에 있어서, Cas9 뉴클레아제가 스타필로코쿠스 아우레우스로부터 단리 또는 유래된 것 (saCas9)인 방법.
  44. 제27항 내지 제43항 중 어느 한 항에 있어서, 대상체가 확장성 심근증(dilated cardiomyopathy)을 앓고 있는 것인 방법.
  45. 제27항 내지 제44항 중 어느 한 항에 있어서, 투여가 대상체의 심근세포의 적어도 30%에서 디스트로핀 발현을 회복시키는 것인 방법.
  46. 제27항 내지 제45항 중 어느 한 항에 있어서, 투여가 적어도 부분적으로 심수축성을 구제하는 것인 방법.
  47. 제27항 내지 제46항 중 어느 한 항에 있어서, 투여가 대상체의 심근세포의 적어도 50%에서 디스트로핀 발현을 회복시키는 것인 방법.
  48. 제27항 내지 제47항 중 어느 한 항에 있어서, 투여가 완전히 심수축성을 구제하는 것인 방법.
  49. 뒤센 근 이영양증 (Duchenne muscular dystrophy: DMD)의 치료 또는 예방을 필요로 하는 대상체에서 DMD를 치료 또는 예방하는 방법으로서,
    유도 만능성 줄기 세포 (iPSc)를,
    Cas9 뉴클레아제, 또는 Cas9 뉴클레아제를 코딩하는 서열, 및
    gRNA, 또는 gRNA를 코딩하는 서열과 접촉시키는 단계로서, 여기서, gRNA는 디스트로핀 유전자의 스플라이스 공여자 또는 스플라이스 수용자 부위를 표적화하는 것인 단계;
    iPSC를 심근세포로 분화시키는 단계; 및
    심근세포를 대상체에게 투여하는 단계를 포함하는, 방법.
KR1020207022943A 2018-01-31 2019-01-31 인간 심근세포에서 디스트로핀 돌연변이를 교정하기 위한 조성물 및 방법 KR20200116933A (ko)

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