KR20200101394A - 엡스타인-바 바이러스 항원 구축물 - Google Patents

엡스타인-바 바이러스 항원 구축물 Download PDF

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KR20200101394A
KR20200101394A KR1020207020466A KR20207020466A KR20200101394A KR 20200101394 A KR20200101394 A KR 20200101394A KR 1020207020466 A KR1020207020466 A KR 1020207020466A KR 20207020466 A KR20207020466 A KR 20207020466A KR 20200101394 A KR20200101394 A KR 20200101394A
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스테파니아 카포네
안토넬라 폴고리
아르민 람
벤자민 위젤
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글락소스미스클라인 바이오로지칼즈 에스.에이.
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  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020207020466A 2017-12-20 2018-12-14 엡스타인-바 바이러스 항원 구축물 KR20200101394A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762608038P 2017-12-20 2017-12-20
US62/608,038 2017-12-20
PCT/IB2018/060101 WO2019123169A1 (en) 2017-12-20 2018-12-14 Epstein-barr virus antigen constructs

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KR20200101394A true KR20200101394A (ko) 2020-08-27

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US (2) US11773139B2 (ja)
EP (1) EP3728291A1 (ja)
JP (2) JP2021507712A (ja)
KR (1) KR20200101394A (ja)
CN (1) CN111801342A (ja)
AU (1) AU2018392884B2 (ja)
BR (1) BR112020012361A2 (ja)
CA (1) CA3085975A1 (ja)
EA (1) EA202091178A1 (ja)
IL (1) IL275296A (ja)
MX (1) MX2020006225A (ja)
SG (1) SG11202005451SA (ja)
WO (1) WO2019123169A1 (ja)

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Publication number Priority date Publication date Assignee Title
CN111394376B (zh) * 2020-03-30 2023-04-28 济宁医学院 一种融合基因bfna、重组腺病毒及其制备方法和应用
WO2023064612A2 (en) * 2021-10-15 2023-04-20 BioNTech SE Pharmaceutical compositions for delivery of viral antigens and related methods
WO2024003239A1 (en) * 2022-06-29 2024-01-04 Bavarian Nordic A/S RECOMBINANT MODIFIED saRNA (VRP) AND VACCINIA VIRUS ANKARA (MVA) PRIME-BOOST REGIMEN
WO2024084091A1 (en) 2022-10-21 2024-04-25 Medizinische Universität Wien Materials and methods to treat epstein-barr virus (ebv) and ebv-induced diseases

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4427117C1 (de) * 1994-07-30 1995-10-19 Gsf Forschungszentrum Umwelt Plasmid und damit transfizierte Zellen
US5716845A (en) 1995-07-20 1998-02-10 Wisconsin Alumni Research Foundation Immortalized lymphocytes for production of viral-free proteins
CA2154854C (en) * 1994-07-30 2006-03-14 William M. Sugden Immortalized lymphocytes for production of viral-free proteins
US6083716A (en) 1996-09-06 2000-07-04 The Trustees Of The University Of Pennsylvania Chimpanzee adenovirus vectors
AU756081B2 (en) * 1997-07-10 2003-01-02 Council Of The Queensland Institute Of Medical Research, The CTL epitopes from EBV
US7445924B2 (en) 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
ES2256323T5 (es) 2000-11-23 2016-11-21 Bavarian Nordic A/S Variante del virus Vaccinia Ankara Modificado
HU228327B1 (en) 2001-06-22 2013-03-28 Wistar Inst Methods of inducing a cytotoxic immune response and recombinant simian adenovirus compositions useful therein
ATE449105T1 (de) 2004-01-23 2009-12-15 Angeletti P Ist Richerche Bio Impfstoffträger für schimpansen-adenovirus
JP4896021B2 (ja) 2004-05-21 2012-03-14 ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド 呼吸器系病原体ワクチンのためのアルファウイルスベクター
FR2881746B1 (fr) * 2005-02-07 2007-04-13 Centre Nat Rech Scient Epitopes t cd4+des antigenes de latence de type i et ii du virus epstein-barr aptes a etre reconnus par la majorite des individus de la population caucasienne et leurs applications
JP4824389B2 (ja) * 2005-10-28 2011-11-30 株式会社医学生物学研究所 エプスタイン−バールウイルス感染細胞を特異的に攻撃する細胞傷害性t細胞エピトープペプチド及びその用途
AU2006338570B2 (en) 2005-11-18 2013-07-11 The Ohio State University Research Foundation Viral gene products and methods for vaccination to prevent viral associated diseases
CA2632402A1 (en) 2005-12-06 2007-06-14 Savine Therapeutics Pty Ltd Treatment of epstein-barr virus-associated diseases
US20090324630A1 (en) * 2008-04-21 2009-12-31 Jensen Michael C Fusion multiviral chimeric antigen
SG172935A1 (en) 2009-02-02 2011-08-29 Okairos Ag Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof
WO2011005799A2 (en) 2009-07-06 2011-01-13 Novartis Ag Self replicating rna molecules and uses thereof
ES2770335T3 (es) 2010-07-06 2020-07-01 Glaxosmithkline Biologicals Sa Administración de ARN para desencadenar múltiples vías inmunológicas
EP4180057A1 (en) 2010-07-06 2023-05-17 GlaxoSmithKline Biologicals S.A. Virion-like delivery particles for self-replicating rna molecules
WO2012048817A2 (en) 2010-10-15 2012-04-19 Bavarian Nordic A/S Recombinant modified vaccinia virus ankara influenza vaccine
WO2012089231A1 (en) 2010-12-30 2012-07-05 Okairòs Ag Paramyxovirus vaccines
JP6091435B2 (ja) 2011-02-22 2017-03-08 カリフォルニア インスティチュート オブ テクノロジー アデノ随伴ウイルス(aav)ベクターを用いたタンパク質の送達
CN110038135B (zh) * 2011-03-17 2021-03-05 伯明翰大学 重新定向的免疫治疗
JP2014522842A (ja) 2011-07-06 2014-09-08 ノバルティス アーゲー 免疫原性組み合わせ組成物およびその使用
EP2729168A2 (en) 2011-07-06 2014-05-14 Novartis AG Immunogenic compositions and uses thereof
CA3158572A1 (en) 2012-08-01 2014-02-06 Bavarian Nordic A/S Recombinant modified vaccinia virus ankara (mva) respiratory syncytial virus (rsv) vaccine
EP3872097A1 (en) * 2012-10-19 2021-09-01 The Council Of The Queensland Institute Of Medical Research Improved human herpesvirus immunotherapy
GB201312133D0 (en) * 2013-07-05 2013-08-21 Univ Birmingham Immunotherapy
EP3054971B1 (en) * 2013-10-11 2021-03-10 The United States of America, represented by the Secretary, Department of Health and Human Services Epstein-barr virus vaccines
EP3888676A1 (en) 2014-06-13 2021-10-06 GlaxoSmithKline Biologicals S.A. Immunogenic combinations
WO2016149384A1 (en) * 2015-03-18 2016-09-22 University Of Massachusetts Virus-like particle compositions and vaccines against epstein-barr virus infection and disease
CN108025058B (zh) * 2015-06-12 2022-12-16 葛兰素史密丝克莱恩生物有限公司 腺病毒多核苷酸和多肽
WO2019055887A1 (en) * 2017-09-16 2019-03-21 City Of Hope PSEUDO-VIRAL PARTICLES OF MULTIVALENT EPSTEIN-BARR VIRUS AND USES THEREOF

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MX2020006225A (es) 2020-12-07
SG11202005451SA (en) 2020-07-29
US20210198321A1 (en) 2021-07-01
CA3085975A1 (en) 2019-06-27
IL275296A (en) 2020-07-30
EP3728291A1 (en) 2020-10-28
US20240076318A1 (en) 2024-03-07
JP2021507712A (ja) 2021-02-25
AU2018392884A1 (en) 2020-06-25
JP2023145678A (ja) 2023-10-11
US11773139B2 (en) 2023-10-03
EA202091178A1 (ru) 2020-09-01
WO2019123169A1 (en) 2019-06-27
AU2018392884B2 (en) 2021-11-11
BR112020012361A2 (pt) 2020-11-24
CN111801342A (zh) 2020-10-20

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