EA202091178A1 - Антигенные конструкции на основе вируса эпштейна-барр - Google Patents
Антигенные конструкции на основе вируса эпштейна-баррInfo
- Publication number
- EA202091178A1 EA202091178A1 EA202091178A EA202091178A EA202091178A1 EA 202091178 A1 EA202091178 A1 EA 202091178A1 EA 202091178 A EA202091178 A EA 202091178A EA 202091178 A EA202091178 A EA 202091178A EA 202091178 A1 EA202091178 A1 EA 202091178A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- barr virus
- epstein
- antigenic
- epshein
- constructions based
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16271—Demonstrated in vivo effect
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
В изобретении предложены антигенные полинуклеотиды, полипептиды и векторы на основе вируса Эпштейна-Барр; а также содержащие их иммуногенные композиции. Изобретение включает применение антигенных конструкций на основе вируса Эпштейна-Барр для получения вакцин для лечения и профилактики инфекций, вызванных вирусом Эпштейна-Барр, и обусловленных вирусом Эпштейна-Барр заболеваний, таких как рассеянный склероз, ревматоидный артрит и системная красная волчанка.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762608038P | 2017-12-20 | 2017-12-20 | |
PCT/IB2018/060101 WO2019123169A1 (en) | 2017-12-20 | 2018-12-14 | Epstein-barr virus antigen constructs |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202091178A1 true EA202091178A1 (ru) | 2020-09-01 |
Family
ID=65363319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202091178A EA202091178A1 (ru) | 2017-12-20 | 2018-12-14 | Антигенные конструкции на основе вируса эпштейна-барр |
Country Status (13)
Country | Link |
---|---|
US (2) | US11773139B2 (ru) |
EP (1) | EP3728291A1 (ru) |
JP (2) | JP2021507712A (ru) |
KR (1) | KR20200101394A (ru) |
CN (2) | CN111801342A (ru) |
AU (1) | AU2018392884B2 (ru) |
BR (1) | BR112020012361A2 (ru) |
CA (1) | CA3085975A1 (ru) |
EA (1) | EA202091178A1 (ru) |
IL (1) | IL275296A (ru) |
MX (1) | MX2020006225A (ru) |
SG (1) | SG11202005451SA (ru) |
WO (1) | WO2019123169A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111394376B (zh) * | 2020-03-30 | 2023-04-28 | 济宁医学院 | 一种融合基因bfna、重组腺病毒及其制备方法和应用 |
WO2023064612A2 (en) * | 2021-10-15 | 2023-04-20 | BioNTech SE | Pharmaceutical compositions for delivery of viral antigens and related methods |
WO2024003239A1 (en) * | 2022-06-29 | 2024-01-04 | Bavarian Nordic A/S | RECOMBINANT MODIFIED saRNA (VRP) AND VACCINIA VIRUS ANKARA (MVA) PRIME-BOOST REGIMEN |
WO2024084091A1 (en) | 2022-10-21 | 2024-04-25 | Medizinische Universität Wien | Materials and methods to treat epstein-barr virus (ebv) and ebv-induced diseases |
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US5716845A (en) * | 1995-07-20 | 1998-02-10 | Wisconsin Alumni Research Foundation | Immortalized lymphocytes for production of viral-free proteins |
DE4427117C1 (de) | 1994-07-30 | 1995-10-19 | Gsf Forschungszentrum Umwelt | Plasmid und damit transfizierte Zellen |
CA2154854C (en) * | 1994-07-30 | 2006-03-14 | William M. Sugden | Immortalized lymphocytes for production of viral-free proteins |
WO1998010087A1 (en) | 1996-09-06 | 1998-03-12 | Trustees Of The University Of Pennsylvania | Chimpanzee adenovirus vectors |
AU756081B2 (en) * | 1997-07-10 | 2003-01-02 | Council Of The Queensland Institute Of Medical Research, The | CTL epitopes from EBV |
CN101676389A (zh) | 2000-11-23 | 2010-03-24 | 巴法里安诺迪克有限公司 | 改良安卡拉痘苗病毒变体 |
US7445924B2 (en) | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
KR20040043129A (ko) | 2001-06-22 | 2004-05-22 | 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 | 세포독성 면역 반응을 유도하는 방법과 그에 유용한재조합체 원숭이 아데노바이러스 조성물 |
EP1711518B1 (en) | 2004-01-23 | 2009-11-18 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Chimpanzee adenovirus vaccine carriers |
WO2006078294A2 (en) | 2004-05-21 | 2006-07-27 | Novartis Vaccines And Diagnostics Inc. | Alphavirus vectors for respiratory pathogen vaccines |
FR2881746B1 (fr) | 2005-02-07 | 2007-04-13 | Centre Nat Rech Scient | Epitopes t cd4+des antigenes de latence de type i et ii du virus epstein-barr aptes a etre reconnus par la majorite des individus de la population caucasienne et leurs applications |
JP4824389B2 (ja) * | 2005-10-28 | 2011-11-30 | 株式会社医学生物学研究所 | エプスタイン−バールウイルス感染細胞を特異的に攻撃する細胞傷害性t細胞エピトープペプチド及びその用途 |
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CN101379078A (zh) * | 2005-12-06 | 2009-03-04 | 赛文医疗私人有限公司 | 爱泼斯坦-巴尔病毒相关疾病的治疗 |
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BRPI1008018A2 (pt) | 2009-02-02 | 2016-03-15 | Okairos Ag | ácidos nucleicos de adenovírus símio e sequências de aminoácidos, vetores contendo os mesmos e uso dos mesmos |
EP2451475A2 (en) | 2009-07-06 | 2012-05-16 | Novartis AG | Self replicating rna molecules and uses thereof |
BR112013000392B8 (pt) | 2010-07-06 | 2022-10-04 | Novartis Ag | Composição farmacêutica contendo partícula de distribuição semelhante a vírion para moléculas de rna autorreplicantes e seu uso |
HUE047796T2 (hu) | 2010-07-06 | 2020-05-28 | Glaxosmithkline Biologicals Sa | RNS bevitele több immunútvonal bekapcsolására |
EP2627774B1 (en) | 2010-10-15 | 2018-11-21 | Bavarian Nordic A/S | Recombinant modified vaccinia virus ankara (mva) influenza vaccine |
WO2012089231A1 (en) | 2010-12-30 | 2012-07-05 | Okairòs Ag | Paramyxovirus vaccines |
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EP2729168A2 (en) | 2011-07-06 | 2014-05-14 | Novartis AG | Immunogenic compositions and uses thereof |
US11896636B2 (en) | 2011-07-06 | 2024-02-13 | Glaxosmithkline Biologicals Sa | Immunogenic combination compositions and uses thereof |
JP6523955B2 (ja) | 2012-08-01 | 2019-06-05 | バヴァリアン・ノルディック・アクティーゼルスカブ | 組換え改変ワクシニアウイルスアンカラ(mva)rsウイルス(rsv)ワクチン |
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WO2019055887A1 (en) * | 2017-09-16 | 2019-03-21 | City Of Hope | PSEUDO-VIRAL PARTICLES OF MULTIVALENT EPSTEIN-BARR VIRUS AND USES THEREOF |
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2018
- 2018-12-14 MX MX2020006225A patent/MX2020006225A/es unknown
- 2018-12-14 SG SG11202005451SA patent/SG11202005451SA/en unknown
- 2018-12-14 JP JP2020534609A patent/JP2021507712A/ja active Pending
- 2018-12-14 CN CN201880089867.5A patent/CN111801342A/zh active Pending
- 2018-12-14 CA CA3085975A patent/CA3085975A1/en active Pending
- 2018-12-14 BR BR112020012361-7A patent/BR112020012361A2/pt unknown
- 2018-12-14 EP EP18845444.1A patent/EP3728291A1/en active Pending
- 2018-12-14 KR KR1020207020466A patent/KR20200101394A/ko not_active Application Discontinuation
- 2018-12-14 EA EA202091178A patent/EA202091178A1/ru unknown
- 2018-12-14 AU AU2018392884A patent/AU2018392884B2/en not_active Ceased
- 2018-12-14 US US16/770,963 patent/US11773139B2/en active Active
- 2018-12-14 CN CN202410465677.6A patent/CN118308379A/zh active Pending
- 2018-12-14 WO PCT/IB2018/060101 patent/WO2019123169A1/en unknown
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2020
- 2020-06-11 IL IL275296A patent/IL275296A/en unknown
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2023
- 2023-07-25 US US18/358,350 patent/US20240076318A1/en active Pending
- 2023-08-02 JP JP2023126388A patent/JP2023145678A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210198321A1 (en) | 2021-07-01 |
CN118308379A (zh) | 2024-07-09 |
AU2018392884A1 (en) | 2020-06-25 |
CA3085975A1 (en) | 2019-06-27 |
US11773139B2 (en) | 2023-10-03 |
JP2023145678A (ja) | 2023-10-11 |
JP2021507712A (ja) | 2021-02-25 |
IL275296A (en) | 2020-07-30 |
AU2018392884B2 (en) | 2021-11-11 |
EP3728291A1 (en) | 2020-10-28 |
KR20200101394A (ko) | 2020-08-27 |
MX2020006225A (es) | 2020-12-07 |
US20240076318A1 (en) | 2024-03-07 |
WO2019123169A1 (en) | 2019-06-27 |
SG11202005451SA (en) | 2020-07-29 |
CN111801342A (zh) | 2020-10-20 |
BR112020012361A2 (pt) | 2020-11-24 |
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