KR20200099556A - 면역자극성 조성물 - Google Patents

면역자극성 조성물 Download PDF

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Publication number
KR20200099556A
KR20200099556A KR1020207020350A KR20207020350A KR20200099556A KR 20200099556 A KR20200099556 A KR 20200099556A KR 1020207020350 A KR1020207020350 A KR 1020207020350A KR 20207020350 A KR20207020350 A KR 20207020350A KR 20200099556 A KR20200099556 A KR 20200099556A
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South Korea
Prior art keywords
artificial sequence
immunostimulatory
composition
oligonucleotide
dna
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Pending
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KR1020207020350A
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English (en)
Korean (ko)
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토마스 일크
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바이엘 애니멀 헬스 게엠베하
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Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020207020350A 2017-12-15 2018-12-07 면역자극성 조성물 Pending KR20200099556A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP17207750 2017-12-15
EP17207746.3 2017-12-15
EP17207746 2017-12-15
EP17207750.5 2017-12-15
EP17207740 2017-12-15
EP17207740.6 2017-12-15
PCT/EP2018/083956 WO2019115385A1 (en) 2017-12-15 2018-12-07 Immunostimulatory compositions

Publications (1)

Publication Number Publication Date
KR20200099556A true KR20200099556A (ko) 2020-08-24

Family

ID=66818991

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020207020350A Pending KR20200099556A (ko) 2017-12-15 2018-12-07 면역자극성 조성물
KR1020207020351A Ceased KR20200098638A (ko) 2017-12-15 2018-12-07 면역자극성 올리고뉴클레오티드
KR1020257009617A Pending KR20250048594A (ko) 2017-12-15 2018-12-07 면역자극성 올리고뉴클레오티드
KR1020207020349A Active KR102787688B1 (ko) 2017-12-15 2018-12-07 면역자극성 올리고뉴클레오티드

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020207020351A Ceased KR20200098638A (ko) 2017-12-15 2018-12-07 면역자극성 올리고뉴클레오티드
KR1020257009617A Pending KR20250048594A (ko) 2017-12-15 2018-12-07 면역자극성 올리고뉴클레오티드
KR1020207020349A Active KR102787688B1 (ko) 2017-12-15 2018-12-07 면역자극성 올리고뉴클레오티드

Country Status (24)

Country Link
US (7) US11542507B2 (https=)
EP (4) EP3700564B1 (https=)
JP (5) JP7458977B2 (https=)
KR (4) KR20200099556A (https=)
CN (5) CN111801116B (https=)
AU (5) AU2018382419B2 (https=)
BR (2) BR112020011815A2 (https=)
CA (3) CA3085661A1 (https=)
CL (3) CL2020001560A1 (https=)
CO (3) CO2020007120A2 (https=)
CR (1) CR20200260A (https=)
DK (1) DK3700564T3 (https=)
DO (3) DOP2020000106A (https=)
ES (1) ES3052969T3 (https=)
IL (3) IL274975A (https=)
MX (4) MX2020006246A (https=)
PE (3) PE20210636A1 (https=)
PH (3) PH12020550904A1 (https=)
PL (1) PL3700564T3 (https=)
SG (3) SG11202004471RA (https=)
TW (3) TWI821224B (https=)
UY (3) UY38015A (https=)
WO (3) WO2019115386A1 (https=)
ZA (1) ZA202004317B (https=)

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EP4295917A3 (en) 2020-08-07 2024-02-28 Tambo, Inc. Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
CN112159814B (zh) * 2020-10-29 2023-05-16 中国农业科学院兰州兽医研究所 一种CpG寡聚脱氧核苷酸及制备与其用途
CN113797329A (zh) * 2021-10-19 2021-12-17 启锰生物科技(江苏)有限公司 一种二价锰佐剂和CpG佐剂的疫苗佐剂组合物及其制作方法
CN116218852A (zh) * 2023-02-22 2023-06-06 中国人民解放军陆军军医大学 一种靶向基因启动子G-四联体区域的sgRNA及其用途
CN120290549A (zh) * 2024-01-09 2025-07-11 康希诺(上海)生物研发有限公司 一种免疫刺激序列截断多聚a尾的序列构建及其应用

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WO2019115402A1 (en) 2019-06-20
RU2020122553A (ru) 2022-01-17
JP7273040B2 (ja) 2023-05-12
JP2023156485A (ja) 2023-10-24
DOP2020000107A (es) 2020-08-31
TW201936924A (zh) 2019-09-16
JP7770769B2 (ja) 2025-11-17
BR112020011838A2 (pt) 2020-11-24
CR20200260A (es) 2020-08-01
KR20200098637A (ko) 2020-08-20
JP7760560B2 (ja) 2025-10-27
EP3700564A1 (en) 2020-09-02
UY38015A (es) 2019-06-28
US20210062192A1 (en) 2021-03-04
AU2025205082A1 (en) 2025-07-31
CN111801419A (zh) 2020-10-20
CO2020007100A2 (es) 2020-06-19
IL275217A (en) 2020-07-30
AU2018382419B2 (en) 2025-04-10
MX2025007909A (es) 2025-08-01
AU2018385257A1 (en) 2020-06-18
TW201936923A (zh) 2019-09-16
KR102787688B1 (ko) 2025-03-27
WO2019115386A1 (en) 2019-06-20
US11542507B2 (en) 2023-01-03
CO2020007120A2 (es) 2020-06-19
DOP2020000106A (es) 2020-08-31
EP4647437A3 (en) 2026-02-18
BR112020011815A2 (pt) 2020-11-17
CN111801116A (zh) 2020-10-20
CN111447949B (zh) 2025-07-11
US20230174990A1 (en) 2023-06-08
US12305173B2 (en) 2025-05-20
TW201940192A (zh) 2019-10-16
DOP2020000113A (es) 2020-08-31
AU2018385256B2 (en) 2025-09-25
AU2018385256A1 (en) 2020-06-11
IL275086A (en) 2020-07-30
CO2020007102A2 (es) 2020-06-19
KR20250048594A (ko) 2025-04-09
PH12020550904A1 (en) 2021-05-17
PE20210636A1 (es) 2021-03-23
MX2020006244A (es) 2020-09-03
BR112020011845A2 (pt) 2020-11-24
CL2020001562A1 (es) 2020-11-06
WO2019115386A9 (en) 2020-07-23
CL2020001561A1 (es) 2020-11-06
AU2025204678A1 (en) 2025-07-17
ZA202004317B (en) 2023-05-31
CL2020001560A1 (es) 2020-11-06
TWI821224B (zh) 2023-11-11
MX2020006243A (es) 2020-09-03
CA3085661A1 (en) 2019-06-20
PL3700564T3 (pl) 2026-02-23
AU2018382419A1 (en) 2020-06-04
US20250215439A1 (en) 2025-07-03
AU2018385257B2 (en) 2025-04-10
PE20210635A1 (es) 2021-03-23
JP2023153970A (ja) 2023-10-18
SG11202004773SA (en) 2020-06-29
CN111801116B (zh) 2024-11-26
EP3700564B1 (en) 2025-09-17
JP2021506779A (ja) 2021-02-22
JP7458977B2 (ja) 2024-04-01
CA3085575A1 (en) 2019-06-20
WO2019115385A1 (en) 2019-06-20
ES3052969T3 (en) 2026-01-16
JP2021506245A (ja) 2021-02-22
RU2020122545A (ru) 2022-01-19
UY38014A (es) 2019-06-28
IL274975A (en) 2020-07-30
EP4647437A2 (en) 2025-11-12
CA3085657A1 (en) 2019-06-20
US11932857B2 (en) 2024-03-19
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