JP7458977B2 - 免疫刺激性組成物 - Google Patents

免疫刺激性組成物 Download PDF

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JP7458977B2
JP7458977B2 JP2020531988A JP2020531988A JP7458977B2 JP 7458977 B2 JP7458977 B2 JP 7458977B2 JP 2020531988 A JP2020531988 A JP 2020531988A JP 2020531988 A JP2020531988 A JP 2020531988A JP 7458977 B2 JP7458977 B2 JP 7458977B2
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immunostimulatory
composition
oligonucleotide
nucleic acid
tg4t
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JP2021506779A (ja
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イルグ，トマス
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Elanco Animal Health GmbH
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Elanco Animal Health GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020531988A 2017-12-15 2018-12-07 免疫刺激性組成物 Active JP7458977B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023134080A JP7760560B2 (ja) 2017-12-15 2023-08-21 免疫刺激性組成物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP17207746 2017-12-15
EP17207740 2017-12-15
EP17207746.3 2017-12-15
EP17207750 2017-12-15
EP17207750.5 2017-12-15
EP17207740.6 2017-12-15
PCT/EP2018/083956 WO2019115385A1 (en) 2017-12-15 2018-12-07 Immunostimulatory compositions

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JP2021506779A JP2021506779A (ja) 2021-02-22
JP7458977B2 true JP7458977B2 (ja) 2024-04-01

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JP2020531988A Active JP7458977B2 (ja) 2017-12-15 2018-12-07 免疫刺激性組成物
JP2020531982A Active JP7770769B2 (ja) 2017-12-15 2018-12-07 免疫刺激性オリゴヌクレオチド
JP2020531972A Active JP7273040B2 (ja) 2017-12-15 2018-12-07 免疫刺激性オリゴヌクレオチド
JP2023128316A Pending JP2023153970A (ja) 2017-12-15 2023-08-07 免疫刺激性オリゴヌクレオチド
JP2023134080A Active JP7760560B2 (ja) 2017-12-15 2023-08-21 免疫刺激性組成物

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JP2020531972A Active JP7273040B2 (ja) 2017-12-15 2018-12-07 免疫刺激性オリゴヌクレオチド
JP2023128316A Pending JP2023153970A (ja) 2017-12-15 2023-08-07 免疫刺激性オリゴヌクレオチド
JP2023134080A Active JP7760560B2 (ja) 2017-12-15 2023-08-21 免疫刺激性組成物

Country Status (24)

Country Link
US (7) US20210062192A1 (https=)
EP (4) EP3700564B1 (https=)
JP (5) JP7458977B2 (https=)
KR (4) KR102787688B1 (https=)
CN (5) CN119656298A (https=)
AU (5) AU2018385257B2 (https=)
BR (2) BR112020011815A2 (https=)
CA (3) CA3085575A1 (https=)
CL (3) CL2020001560A1 (https=)
CO (3) CO2020007120A2 (https=)
CR (1) CR20200260A (https=)
DK (1) DK3700564T3 (https=)
DO (3) DOP2020000106A (https=)
ES (1) ES3052969T3 (https=)
IL (3) IL274975A (https=)
MX (4) MX2020006244A (https=)
PE (3) PE20210635A1 (https=)
PH (3) PH12020550906A1 (https=)
PL (1) PL3700564T3 (https=)
SG (3) SG11202004471RA (https=)
TW (3) TWI821224B (https=)
UY (3) UY38016A (https=)
WO (3) WO2019115386A1 (https=)
ZA (1) ZA202004317B (https=)

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WO2021154745A1 (en) * 2020-01-27 2021-08-05 Oregon State University Gonorrhea subunit vaccine
CN113493790A (zh) 2020-04-01 2021-10-12 南京华普生物技术股份有限公司 具有免疫调节功能的CpG ODN及其应用
EP3892260A1 (en) * 2020-04-10 2021-10-13 Bayer Animal Health GmbH Immunostimulatory compositions based on liposomes with zwiterionic and cationic lipids
CN116056765A (zh) 2020-08-07 2023-05-02 坦伯公司 反式环辛烯生物正交剂及在癌症和免疫疗法中的用途
CN112159814B (zh) * 2020-10-29 2023-05-16 中国农业科学院兰州兽医研究所 一种CpG寡聚脱氧核苷酸及制备与其用途
CN113797329A (zh) * 2021-10-19 2021-12-17 启锰生物科技(江苏)有限公司 一种二价锰佐剂和CpG佐剂的疫苗佐剂组合物及其制作方法
CN116218852A (zh) * 2023-02-22 2023-06-06 中国人民解放军陆军军医大学 一种靶向基因启动子G-四联体区域的sgRNA及其用途
WO2025149000A1 (zh) * 2024-01-09 2025-07-17 康希诺(上海)生物研发有限公司 一种免疫刺激序列截断多聚a尾的序列构建及其应用

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JP2014507131A (ja) 2010-12-30 2014-03-27 インターベツト・インターナシヨナル・ベー・ベー 免疫賦活性オリゴデオキシヌクレオチド
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PH12020550904A1 (en) 2021-05-17
CO2020007102A2 (es) 2020-06-19
JP7273040B2 (ja) 2023-05-12
CR20200260A (es) 2020-08-01
US20210170020A1 (en) 2021-06-10
US20210062192A1 (en) 2021-03-04
JP2021506779A (ja) 2021-02-22
MX2020006246A (es) 2020-09-03
AU2018385257A1 (en) 2020-06-18
CN111447949B (zh) 2025-07-11
US11932857B2 (en) 2024-03-19
KR20250048594A (ko) 2025-04-09
CL2020001560A1 (es) 2020-11-06
US20230332162A1 (en) 2023-10-19
AU2025205082A1 (en) 2025-07-31
US20230174990A1 (en) 2023-06-08
EP3701032A1 (en) 2020-09-02
TW201940192A (zh) 2019-10-16
US11542507B2 (en) 2023-01-03
AU2018382419B2 (en) 2025-04-10
DOP2020000107A (es) 2020-08-31
DOP2020000113A (es) 2020-08-31
SG11202004773SA (en) 2020-06-29
WO2019115402A1 (en) 2019-06-20
BR112020011838A2 (pt) 2020-11-24
KR20200099556A (ko) 2020-08-24
IL275217A (en) 2020-07-30
IL274975A (en) 2020-07-30
CN111801419A (zh) 2020-10-20
CO2020007100A2 (es) 2020-06-19
TWI911138B (zh) 2026-01-11
TW201936924A (zh) 2019-09-16
SG11202004952UA (en) 2020-06-29
KR20200098637A (ko) 2020-08-20
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PE20210636A1 (es) 2021-03-23
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