KR20200052297A - Pi3k델타 억제제로서의 이미다조[1,5-a]피라진 유도체 - Google Patents

Pi3k델타 억제제로서의 이미다조[1,5-a]피라진 유도체 Download PDF

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KR20200052297A
KR20200052297A KR1020207007386A KR20207007386A KR20200052297A KR 20200052297 A KR20200052297 A KR 20200052297A KR 1020207007386 A KR1020207007386 A KR 1020207007386A KR 20207007386 A KR20207007386 A KR 20207007386A KR 20200052297 A KR20200052297 A KR 20200052297A
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compound
alkyl
optionally substituted
cycloalkyl
heterocyclyl
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징 리
하이보 자오
즈위 왕
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베이진 엘티디
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020207007386A 2017-09-08 2018-09-07 Pi3k델타 억제제로서의 이미다조[1,5-a]피라진 유도체 Pending KR20200052297A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CNPCT/CN2017/101058 2017-09-08
CN2017101058 2017-09-08
CN2017119373 2017-12-28
CNPCT/CN2017/119373 2017-12-28
CN2018086555 2018-05-11
CNPCT/CN2018/086555 2018-05-11
PCT/CN2018/104559 WO2019047915A1 (en) 2017-09-08 2018-09-07 IMIDAZO [1,5-A] PYRAZINE DERIVATIVES AS PI3KDELTA INHIBITORS

Publications (1)

Publication Number Publication Date
KR20200052297A true KR20200052297A (ko) 2020-05-14

Family

ID=65633578

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207007386A Pending KR20200052297A (ko) 2017-09-08 2018-09-07 Pi3k델타 억제제로서의 이미다조[1,5-a]피라진 유도체

Country Status (21)

Country Link
US (3) US11220506B2 (https=)
EP (2) EP3679042B1 (https=)
JP (1) JP7128264B2 (https=)
KR (1) KR20200052297A (https=)
CN (2) CN111704615B (https=)
AU (2) AU2018328569B2 (https=)
BR (1) BR112020004500A2 (https=)
CA (1) CA3072842A1 (https=)
DK (1) DK3679042T3 (https=)
ES (1) ES2944658T3 (https=)
FI (1) FI3679042T3 (https=)
HU (1) HUE061898T2 (https=)
IL (1) IL272988B (https=)
MX (1) MX2020002630A (https=)
NZ (1) NZ761680A (https=)
PL (1) PL3679042T3 (https=)
PT (1) PT3679042T (https=)
SG (1) SG11202001286SA (https=)
TW (2) TWI817956B (https=)
WO (1) WO2019047915A1 (https=)
ZA (1) ZA202000875B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3045959A1 (en) 2016-12-07 2018-06-14 Beigene, Ltd. Imidazo [1,5-a] pyrazine derivatives as pi3kdelta inhibitors
BR112020004500A2 (pt) 2017-09-08 2020-12-01 Beigene, Ltd. derivados de imidazo [1,5-a] pirazina como inibidores de pi3kdelta
US20230011916A1 (en) * 2019-11-21 2023-01-12 Beigene, Ltd. Methods of cancer treatment using anti-ox40 antibodies in combination with pi3 kinase delta inhibitors
AU2022280905A1 (en) * 2021-05-27 2024-01-18 Beigene Switzerland Gmbh SALTS OF A PI3Kdelta INHIBITOR, CRYSTALLINE FORMS, METHODS OF PREPARATION, AND USES THEREFORE
WO2023040810A1 (en) * 2021-09-14 2023-03-23 Beigene, Ltd. Methods of cancer treatment using a combination of btk inhibitors and pi3 kinase inhibitors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005089352A (ja) * 2003-09-16 2005-04-07 Kissei Pharmaceut Co Ltd 新規なイミダゾ［１，５−ａ］ピラジン誘導体、それを含有する医薬組成物およびそれらの用途
UA83509C2 (en) * 2003-10-15 2008-07-25 Оси Фармасьютикалз, Инк. Imidazopyrazines as tyrosine kinase inhibitors
TW200738725A (en) * 2006-01-25 2007-10-16 Osi Pharm Inc Unsaturated mTOR inhibitors
US20120077813A1 (en) * 2009-04-15 2012-03-29 Astrazeneca Ab Imidazole Substituted Pyrimidines Useful in the Treatment of Glycogen Synthase Kinase-3 Related Disorders such as Alzheimer's Disease
BRPI1014572B8 (pt) 2009-04-16 2022-07-19 Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii Imidazopirazinas para uso como inibidores de cinase
RU2013138835A (ru) * 2011-02-09 2015-03-20 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения в качестве ингибиторов pi3 киназы
ES2588186T3 (es) 2012-01-10 2016-10-31 Bayer Intellectual Property Gmbh Imidazopirazinas sustituidas como inhibidores de la quinasa Akt
AU2013337717B2 (en) 2012-11-01 2018-10-25 Infinity Pharmaceuticals, Inc. Treatment of cancers using PI3 kinase isoform modulators
TWI687220B (zh) * 2013-03-01 2020-03-11 美商英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途
CA2914284A1 (en) 2013-05-30 2014-12-04 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
CA2922058A1 (en) * 2013-10-18 2015-04-23 Medivation Technologies, Inc. Heterocyclic compounds and methods of use
PL3179991T3 (pl) * 2014-08-11 2022-02-14 Acerta Pharma B.V. Kombinacje terapeutyczne inhibitora btk i inhibitora bcl-2
AR102220A1 (es) * 2015-10-08 2017-02-15 Incyte Corp Imidazopiridinas e imidazopirazinas como inhibidores de lsd1
HRP20210508T1 (hr) * 2016-06-16 2021-05-28 Janssen Pharmaceutica Nv Biciklički derivati piridina, pirazina i pirimidina kao inhibitori pi3k beta
CA3045959A1 (en) * 2016-12-07 2018-06-14 Beigene, Ltd. Imidazo [1,5-a] pyrazine derivatives as pi3kdelta inhibitors
BR112020004500A2 (pt) 2017-09-08 2020-12-01 Beigene, Ltd. derivados de imidazo [1,5-a] pirazina como inibidores de pi3kdelta

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Publication number Publication date
BR112020004500A2 (pt) 2020-12-01
CN111051312A (zh) 2020-04-21
PT3679042T (pt) 2023-05-18
ZA202000875B (en) 2021-07-28
DK3679042T3 (da) 2023-05-01
EP3679042A4 (en) 2021-01-13
ES2944658T3 (es) 2023-06-23
US11220506B2 (en) 2022-01-11
PL3679042T3 (pl) 2023-09-04
US11905294B2 (en) 2024-02-20
HUE061898T2 (hu) 2023-08-28
EP4219502A1 (en) 2023-08-02
IL272988B (en) 2022-08-01
JP2020534259A (ja) 2020-11-26
CA3072842A1 (en) 2019-03-14
TW201920116A (zh) 2019-06-01
EP3679042B1 (en) 2023-03-01
CN111704615B (zh) 2023-02-17
CN111704615A (zh) 2020-09-25
AU2018328569B2 (en) 2023-07-27
JP7128264B2 (ja) 2022-08-30
US20240150361A1 (en) 2024-05-09
IL272988A (en) 2020-04-30
WO2019047915A1 (en) 2019-03-14
US20220081447A1 (en) 2022-03-17
NZ761680A (en) 2023-03-31
AU2018328569A1 (en) 2020-02-27
TW202336010A (zh) 2023-09-16
EP3679042A1 (en) 2020-07-15
MX2020002630A (es) 2020-07-20
FI3679042T3 (fi) 2023-05-15
SG11202001286SA (en) 2020-03-30
AU2023254925A1 (en) 2023-11-16
TWI817956B (zh) 2023-10-11
US20200207774A1 (en) 2020-07-02

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