KR20190128646A - 혈액 종양 환자들의 치료 방법 - Google Patents

혈액 종양 환자들의 치료 방법 Download PDF

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Publication number
KR20190128646A
KR20190128646A KR1020197027330A KR20197027330A KR20190128646A KR 20190128646 A KR20190128646 A KR 20190128646A KR 1020197027330 A KR1020197027330 A KR 1020197027330A KR 20197027330 A KR20197027330 A KR 20197027330A KR 20190128646 A KR20190128646 A KR 20190128646A
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KR
South Korea
Prior art keywords
flt3
leukemia
itd
mutated
point mutation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020197027330A
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English (en)
Korean (ko)
Inventor
윌리암 쥐 라이스
조중명
홍용래
Original Assignee
압토스 바이오사이언시스 인코포레이티드
크리스탈지노믹스(주)
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Publication date
Application filed by 압토스 바이오사이언시스 인코포레이티드, 크리스탈지노믹스(주) filed Critical 압토스 바이오사이언시스 인코포레이티드
Publication of KR20190128646A publication Critical patent/KR20190128646A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020197027330A 2017-02-21 2018-02-21 혈액 종양 환자들의 치료 방법 Ceased KR20190128646A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762461584P 2017-02-21 2017-02-21
US62/461,584 2017-02-21
US201762578948P 2017-10-30 2017-10-30
US62/578,948 2017-10-30
PCT/US2018/018951 WO2018156578A1 (en) 2017-02-21 2018-02-21 Methods for treating patients with hematologic malignancies

Publications (1)

Publication Number Publication Date
KR20190128646A true KR20190128646A (ko) 2019-11-18

Family

ID=63253344

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197027330A Ceased KR20190128646A (ko) 2017-02-21 2018-02-21 혈액 종양 환자들의 치료 방법

Country Status (11)

Country Link
US (2) US20180344702A1 (enExample)
EP (1) EP3585778A4 (enExample)
JP (2) JP7227913B2 (enExample)
KR (1) KR20190128646A (enExample)
CN (1) CN110621665A (enExample)
AU (2) AU2018225539B2 (enExample)
CA (1) CA3054196A1 (enExample)
IL (1) IL268736A (enExample)
MX (1) MX2019009954A (enExample)
TW (1) TWI821174B (enExample)
WO (1) WO2018156578A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3559038B1 (en) 2016-12-21 2022-12-14 The United States of America as represented by The Secretary Department of Health and Human Services Human monoclonal antibodies specific for flt3 and uses thereof
KR101954370B1 (ko) 2018-07-25 2019-03-05 한미약품 주식회사 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물
US20200171001A1 (en) * 2018-11-30 2020-06-04 Aptose Biosciences Inc. Combination therapy with 2,3-dihydro-isoindole-1-one compounds and methods for treating patients with various mutations
BR112021016522A2 (pt) 2019-02-22 2021-10-26 Hanmi Pharm. Co., Ltd. Composição farmacêutica para o tratamento da leucemia mieloide aguda
EP3991733A4 (en) 2019-06-27 2023-07-05 Hanmi Pharm. Co., Ltd. Pharmaceutical composition for treating acute myeloid leukemia, containing flt3 inhibitor and chemotherapeutic agents
CN114828842A (zh) * 2019-10-21 2022-07-29 理森制药股份公司 用于治疗急性髓系白血病的包含dhodh抑制剂的组合物
US20240091226A1 (en) * 2021-01-05 2024-03-21 Sumitomo Pharma Oncology, Inc. Forms and Formulations Of A Tyrosine Kinase Non-Receptor 1 (TNK1) Inhibitor
CN117295737A (zh) * 2021-03-05 2023-12-26 林伯士萨顿公司 Hpk1拮抗剂和其用途
WO2022213062A1 (en) 2021-03-29 2022-10-06 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
WO2023129667A1 (en) 2021-12-30 2023-07-06 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of flt3
CN120857931A (zh) * 2022-12-10 2025-10-28 艾普托斯生物科学公司 用于治疗患有血液学恶性病的患者的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012047017A2 (ko) * 2010-10-05 2012-04-12 크리스탈지노믹스(주) 2,3-디히드로-이소인돌-1-온 유도체 및 이를 포함하는 조성물
DK2940014T3 (en) * 2012-12-28 2018-12-10 Crystalgenomics Inc 2,3-DIHYDRO-ISOINDOL-1-ON DERIVATIVE AS BTK KINase INHIBITORS AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME
US10463658B2 (en) * 2013-10-25 2019-11-05 Videra Pharmaceuticals, Llc Method of inhibiting FLT3 kinase
EP3062809B1 (en) * 2013-10-31 2020-07-08 Biokine Therapeutics Ltd. A cxcr4 peptide inhibitor for use in treating acute myeloid leukemia with a flt3 mutation

Also Published As

Publication number Publication date
CN110621665A (zh) 2019-12-27
MX2019009954A (es) 2019-12-19
AU2018225539B2 (en) 2022-07-14
EP3585778A4 (en) 2020-12-02
TWI821174B (zh) 2023-11-11
IL268736A (en) 2019-10-31
AU2022252696B2 (en) 2025-01-30
TW201842906A (zh) 2018-12-16
JP2023022330A (ja) 2023-02-14
US20180344702A1 (en) 2018-12-06
CA3054196A1 (en) 2018-08-30
WO2018156578A1 (en) 2018-08-30
AU2022252696A1 (en) 2022-11-03
US20230012148A1 (en) 2023-01-12
JP2020508313A (ja) 2020-03-19
AU2018225539A1 (en) 2019-09-05
JP7431309B2 (ja) 2024-02-14
JP7227913B2 (ja) 2023-02-22
EP3585778A1 (en) 2020-01-01

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