TWI821174B - 治療血液惡性腫瘤患者的方法 - Google Patents

治療血液惡性腫瘤患者的方法 Download PDF

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Publication number
TWI821174B
TWI821174B TW107105790A TW107105790A TWI821174B TW I821174 B TWI821174 B TW I821174B TW 107105790 A TW107105790 A TW 107105790A TW 107105790 A TW107105790 A TW 107105790A TW I821174 B TWI821174 B TW I821174B
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TW
Taiwan
Prior art keywords
flt3
leukemia
cell
compound
btk
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TW107105790A
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English (en)
Chinese (zh)
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TW201842906A (zh
Inventor
威廉 萊斯
曹重明
洪庸萊
Original Assignee
加拿大商艾普托斯生物科學公司
南韓商晶體基因技術股份有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW107105790A 2017-02-21 2018-02-21 治療血液惡性腫瘤患者的方法 TWI821174B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762461584P 2017-02-21 2017-02-21
US62/461,584 2017-02-21
US201762578948P 2017-10-30 2017-10-30
US62/578,948 2017-10-30

Publications (2)

Publication Number Publication Date
TW201842906A TW201842906A (zh) 2018-12-16
TWI821174B true TWI821174B (zh) 2023-11-11

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TW107105790A TWI821174B (zh) 2017-02-21 2018-02-21 治療血液惡性腫瘤患者的方法

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US (2) US20180344702A1 (enExample)
EP (1) EP3585778A4 (enExample)
JP (2) JP7227913B2 (enExample)
KR (1) KR20190128646A (enExample)
CN (1) CN110621665A (enExample)
AU (2) AU2018225539B2 (enExample)
CA (1) CA3054196A1 (enExample)
IL (1) IL268736A (enExample)
MX (1) MX2019009954A (enExample)
TW (1) TWI821174B (enExample)
WO (1) WO2018156578A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3559038B1 (en) 2016-12-21 2022-12-14 The United States of America as represented by The Secretary Department of Health and Human Services Human monoclonal antibodies specific for flt3 and uses thereof
KR101954370B1 (ko) 2018-07-25 2019-03-05 한미약품 주식회사 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물
US20200171001A1 (en) * 2018-11-30 2020-06-04 Aptose Biosciences Inc. Combination therapy with 2,3-dihydro-isoindole-1-one compounds and methods for treating patients with various mutations
BR112021016522A2 (pt) 2019-02-22 2021-10-26 Hanmi Pharm. Co., Ltd. Composição farmacêutica para o tratamento da leucemia mieloide aguda
EP3991733A4 (en) 2019-06-27 2023-07-05 Hanmi Pharm. Co., Ltd. Pharmaceutical composition for treating acute myeloid leukemia, containing flt3 inhibitor and chemotherapeutic agents
CN114828842A (zh) * 2019-10-21 2022-07-29 理森制药股份公司 用于治疗急性髓系白血病的包含dhodh抑制剂的组合物
US20240091226A1 (en) * 2021-01-05 2024-03-21 Sumitomo Pharma Oncology, Inc. Forms and Formulations Of A Tyrosine Kinase Non-Receptor 1 (TNK1) Inhibitor
CN117295737A (zh) * 2021-03-05 2023-12-26 林伯士萨顿公司 Hpk1拮抗剂和其用途
WO2022213062A1 (en) 2021-03-29 2022-10-06 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
WO2023129667A1 (en) 2021-12-30 2023-07-06 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of flt3
CN120857931A (zh) * 2022-12-10 2025-10-28 艾普托斯生物科学公司 用于治疗患有血液学恶性病的患者的方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN104995184A (zh) * 2012-12-28 2015-10-21 晶体基因技术株式会社 作为btk激酶抑制剂的2,3-二氢异吲哚-1-酮诱导体与含此类的药学组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012047017A2 (ko) * 2010-10-05 2012-04-12 크리스탈지노믹스(주) 2,3-디히드로-이소인돌-1-온 유도체 및 이를 포함하는 조성물
US10463658B2 (en) * 2013-10-25 2019-11-05 Videra Pharmaceuticals, Llc Method of inhibiting FLT3 kinase
EP3062809B1 (en) * 2013-10-31 2020-07-08 Biokine Therapeutics Ltd. A cxcr4 peptide inhibitor for use in treating acute myeloid leukemia with a flt3 mutation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104995184A (zh) * 2012-12-28 2015-10-21 晶体基因技术株式会社 作为btk激酶抑制剂的2,3-二氢异吲哚-1-酮诱导体与含此类的药学组合物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
期刊 Pillinger, Genevra, et al. "Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia." Scientific reports 5.1 (2015): 1-9.; *
期刊 Smith, Catherine C., et al. "FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors." Leukemia 29.12 (2015): 2390-2392.; *
網路文獻 4. Aptose Prioritizes Development of CG’806 First-in Class FLT3/BTK Inhibitor， 2017.1.23， 網址： https://www.globenewswire.com/news-release/2017/01/23/909938/35575/en/Aptose-Prioritizes-Development-of-CG-806-First-in-Class-FLT3-BTK-Inhibitor.html *
網路文獻 4. Aptose Prioritizes Development of CG’806 First-in Class FLT3/BTK Inhibitor， 2017.1.23， 網址： https://www.globenewswire.com/news-release/2017/01/23/909938/35575/en/Aptose-Prioritizes-Development-of-CG-806-First-in-Class-FLT3-BTK-Inhibitor.html。

Also Published As

Publication number Publication date
CN110621665A (zh) 2019-12-27
MX2019009954A (es) 2019-12-19
AU2018225539B2 (en) 2022-07-14
EP3585778A4 (en) 2020-12-02
IL268736A (en) 2019-10-31
AU2022252696B2 (en) 2025-01-30
TW201842906A (zh) 2018-12-16
JP2023022330A (ja) 2023-02-14
US20180344702A1 (en) 2018-12-06
CA3054196A1 (en) 2018-08-30
WO2018156578A1 (en) 2018-08-30
AU2022252696A1 (en) 2022-11-03
KR20190128646A (ko) 2019-11-18
US20230012148A1 (en) 2023-01-12
JP2020508313A (ja) 2020-03-19
AU2018225539A1 (en) 2019-09-05
JP7431309B2 (ja) 2024-02-14
JP7227913B2 (ja) 2023-02-22
EP3585778A1 (en) 2020-01-01

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