CN110621665A - 用于治疗患有恶性血液病的患者的方法 - Google Patents
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201762461584P | 2017-02-21 | 2017-02-21 | |
| US62/461,584 | 2017-02-21 | ||
| US201762578948P | 2017-10-30 | 2017-10-30 | |
| US62/578,948 | 2017-10-30 | ||
| PCT/US2018/018951 WO2018156578A1 (en) | 2017-02-21 | 2018-02-21 | Methods for treating patients with hematologic malignancies |
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| CN110621665A true CN110621665A (zh) | 2019-12-27 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116829143A (zh) * | 2021-01-05 | 2023-09-29 | 住友制药肿瘤公司 | 非受体型酪氨酸激酶1（tnk1）抑制剂的形式和制剂 |
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| EP3559038B1 (en) | 2016-12-21 | 2022-12-14 | The United States of America as represented by The Secretary Department of Health and Human Services | Human monoclonal antibodies specific for flt3 and uses thereof |
| KR101954370B1 (ko) | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| US20200171001A1 (en) * | 2018-11-30 | 2020-06-04 | Aptose Biosciences Inc. | Combination therapy with 2,3-dihydro-isoindole-1-one compounds and methods for treating patients with various mutations |
| BR112021016522A2 (pt) | 2019-02-22 | 2021-10-26 | Hanmi Pharm. Co., Ltd. | Composição farmacêutica para o tratamento da leucemia mieloide aguda |
| EP3991733A4 (en) | 2019-06-27 | 2023-07-05 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition for treating acute myeloid leukemia, containing flt3 inhibitor and chemotherapeutic agents |
| CN114828842A (zh) * | 2019-10-21 | 2022-07-29 | 理森制药股份公司 | 用于治疗急性髓系白血病的包含dhodh抑制剂的组合物 |
| CN117295737A (zh) * | 2021-03-05 | 2023-12-26 | 林伯士萨顿公司 | Hpk1拮抗剂和其用途 |
| WO2022213062A1 (en) | 2021-03-29 | 2022-10-06 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
| WO2023129667A1 (en) | 2021-12-30 | 2023-07-06 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of flt3 |
| CN120857931A (zh) * | 2022-12-10 | 2025-10-28 | 艾普托斯生物科学公司 | 用于治疗患有血液学恶性病的患者的方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150119421A1 (en) * | 2013-10-25 | 2015-04-30 | Arog Pharmaceuticals, Llc | Method of inhibiting flt3 kinase |
| CN104995184A (zh) * | 2012-12-28 | 2015-10-21 | 晶体基因技术株式会社 | 作为btk激酶抑制剂的2,3-二氢异吲哚-1-酮诱导体与含此类的药学组合物 |
| CN106029084A (zh) * | 2013-10-31 | 2016-10-12 | 百欧肯治疗有限公司 | 治疗具有类fms酪氨酸激酶3突变的急性骨髓性白血病的方法 |
Family Cites Families (1)
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|---|---|---|---|---|
| WO2012047017A2 (ko) * | 2010-10-05 | 2012-04-12 | 크리스탈지노믹스(주) | 2,3-디히드로-이소인돌-1-온 유도체 및 이를 포함하는 조성물 |
-
2018
- 2018-02-21 KR KR1020197027330A patent/KR20190128646A/ko not_active Ceased
- 2018-02-21 TW TW107105790A patent/TWI821174B/zh active
- 2018-02-21 MX MX2019009954A patent/MX2019009954A/es unknown
- 2018-02-21 JP JP2019545304A patent/JP7227913B2/ja active Active
- 2018-02-21 AU AU2018225539A patent/AU2018225539B2/en active Active
- 2018-02-21 EP EP18756992.6A patent/EP3585778A4/en not_active Withdrawn
- 2018-02-21 WO PCT/US2018/018951 patent/WO2018156578A1/en not_active Ceased
- 2018-02-21 CA CA3054196A patent/CA3054196A1/en not_active Withdrawn
- 2018-02-21 CN CN201880018924.0A patent/CN110621665A/zh active Pending
- 2018-02-21 US US15/901,439 patent/US20180344702A1/en not_active Abandoned
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2019
- 2019-08-15 IL IL26873619A patent/IL268736A/en unknown
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2022
- 2022-02-18 US US17/675,469 patent/US20230012148A1/en not_active Abandoned
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- 2022-12-12 JP JP2022197816A patent/JP7431309B2/ja active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104995184A (zh) * | 2012-12-28 | 2015-10-21 | 晶体基因技术株式会社 | 作为btk激酶抑制剂的2,3-二氢异吲哚-1-酮诱导体与含此类的药学组合物 |
| US20150119421A1 (en) * | 2013-10-25 | 2015-04-30 | Arog Pharmaceuticals, Llc | Method of inhibiting flt3 kinase |
| CN106029084A (zh) * | 2013-10-31 | 2016-10-12 | 百欧肯治疗有限公司 | 治疗具有类fms酪氨酸激酶3突变的急性骨髓性白血病的方法 |
Non-Patent Citations (3)
| Title |
|---|
| CC SMITH等: "FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors", 《LEUKEMIA》 * |
| D. GARY GILLILAND 等: "The roles of FLT3 in hematopoiesis and leukemia", 《BLOOD》 * |
| DONALD SMALL: "FLT3 Mutations: Biology and Treatment", 《HEMATOLOGY AM SOC HEMATOL EDUC PROGRAM》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116829143A (zh) * | 2021-01-05 | 2023-09-29 | 住友制药肿瘤公司 | 非受体型酪氨酸激酶1（tnk1）抑制剂的形式和制剂 |
Also Published As
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|---|---|
| MX2019009954A (es) | 2019-12-19 |
| AU2018225539B2 (en) | 2022-07-14 |
| EP3585778A4 (en) | 2020-12-02 |
| TWI821174B (zh) | 2023-11-11 |
| IL268736A (en) | 2019-10-31 |
| AU2022252696B2 (en) | 2025-01-30 |
| TW201842906A (zh) | 2018-12-16 |
| JP2023022330A (ja) | 2023-02-14 |
| US20180344702A1 (en) | 2018-12-06 |
| CA3054196A1 (en) | 2018-08-30 |
| WO2018156578A1 (en) | 2018-08-30 |
| AU2022252696A1 (en) | 2022-11-03 |
| KR20190128646A (ko) | 2019-11-18 |
| US20230012148A1 (en) | 2023-01-12 |
| JP2020508313A (ja) | 2020-03-19 |
| AU2018225539A1 (en) | 2019-09-05 |
| JP7431309B2 (ja) | 2024-02-14 |
| JP7227913B2 (ja) | 2023-02-22 |
| EP3585778A1 (en) | 2020-01-01 |
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