KR20190117609A - 3'-데아미노-3'-(2＂-피롤린-1＂-일)-5-이미노-13-데옥시안트라시클린 및 제조 방법 - Google Patents

3'-데아미노-3'-(2＂-피롤린-1＂-일)-5-이미노-13-데옥시안트라시클린 및 제조 방법 Download PDF

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Publication number
KR20190117609A
KR20190117609A KR1020197026451A KR20197026451A KR20190117609A KR 20190117609 A KR20190117609 A KR 20190117609A KR 1020197026451 A KR1020197026451 A KR 1020197026451A KR 20197026451 A KR20197026451 A KR 20197026451A KR 20190117609 A KR20190117609 A KR 20190117609A
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KR
South Korea
Prior art keywords
compound
pyrrolino
pharmaceutically acceptable
group
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1020197026451A
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English (en)
Korean (ko)
Inventor
리차드 올슨
제랄드 월시
Original Assignee
모노파르 테라퓨틱스 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 모노파르 테라퓨틱스 인크. filed Critical 모노파르 테라퓨틱스 인크.
Publication of KR20190117609A publication Critical patent/KR20190117609A/ko
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020197026451A 2017-02-16 2018-02-16 3'-데아미노-3'-(2＂-피롤린-1＂-일)-5-이미노-13-데옥시안트라시클린 및 제조 방법 Abandoned KR20190117609A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/434,617 US10450340B2 (en) 2017-02-16 2017-02-16 3′-deamino-3′-(2″-pyrroline-1″-yl)-5-imino-13-deoxyanthracyclines and methods of preparation
US15/434,617 2017-02-16
PCT/US2018/000090 WO2018151872A1 (en) 2017-02-16 2018-02-16 3'deamino-3'-(2"-pyrroline-1"-yl)-5-imino-13-deoxyanthracyclines and methods of preparation

Publications (1)

Publication Number Publication Date
KR20190117609A true KR20190117609A (ko) 2019-10-16

Family

ID=61692048

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197026451A Abandoned KR20190117609A (ko) 2017-02-16 2018-02-16 3'-데아미노-3'-(2＂-피롤린-1＂-일)-5-이미노-13-데옥시안트라시클린 및 제조 방법

Country Status (11)

Country Link
US (1) US10450340B2 (https=)
EP (1) EP3582788A1 (https=)
JP (1) JP7159177B2 (https=)
KR (1) KR20190117609A (https=)
CN (1) CN110573165B (https=)
AU (1) AU2018220520A1 (https=)
BR (1) BR112019017166A2 (https=)
CA (1) CA3053417A1 (https=)
IL (1) IL268680B (https=)
MX (1) MX388090B (https=)
WO (1) WO2018151872A1 (https=)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
US5948896A (en) 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
US5942605A (en) 1998-03-03 1999-08-24 Gem Pharmaceuticals, Inc. 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them
US7244829B2 (en) 2004-11-08 2007-07-17 Gem Pharmaceuticals, Llc Compositions and processes for preparing 13-deoxy-anthracyclines
JP2007261976A (ja) 2006-03-28 2007-10-11 Meiji Seika Kaisha Ltd 抗腫瘍性アンスラサイクリン系抗生物質の製造法
US7776832B2 (en) 2006-04-21 2010-08-17 Gem Pharmaceuticals, Llc Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines
US9904704B2 (en) 2014-04-22 2018-02-27 Openx Software Limited System and method for controlling audience data and tracking

Also Published As

Publication number Publication date
MX388090B (es) 2025-03-19
RU2019128837A3 (https=) 2021-06-17
BR112019017166A2 (pt) 2020-04-14
US20180230175A1 (en) 2018-08-16
MX2019009733A (es) 2020-02-07
AU2018220520A1 (en) 2019-09-05
CN110573165A (zh) 2019-12-13
CA3053417A1 (en) 2018-08-23
EP3582788A1 (en) 2019-12-25
CN110573165B (zh) 2023-07-11
JP7159177B2 (ja) 2022-10-24
JP2020507608A (ja) 2020-03-12
RU2019128837A (ru) 2021-03-16
IL268680B (en) 2022-02-01
IL268680A (en) 2019-10-31
US10450340B2 (en) 2019-10-22
WO2018151872A1 (en) 2018-08-23

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