CN110573165B - 3’-脱氨基-3’-(2’’-吡咯啉-1’’-基)-5-亚氨基-13-脱氧蒽环及制备方法 - Google Patents

3’-脱氨基-3’-(2’’-吡咯啉-1’’-基)-5-亚氨基-13-脱氧蒽环及制备方法 Download PDF

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Publication number
CN110573165B
CN110573165B CN201880025418.4A CN201880025418A CN110573165B CN 110573165 B CN110573165 B CN 110573165B CN 201880025418 A CN201880025418 A CN 201880025418A CN 110573165 B CN110573165 B CN 110573165B
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CN
China
Prior art keywords
compound
pyrrolino
pharmaceutically acceptable
anthracycline
alkyl
Prior art date
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Expired - Fee Related
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CN201880025418.4A
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English (en)
Chinese (zh)
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CN110573165A (zh
Inventor
R.奥尔森
G.沃尔什
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Valerio Therapeutics SA
Original Assignee
Onxeo SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201880025418.4A 2017-02-16 2018-02-16 3’-脱氨基-3’-(2’’-吡咯啉-1’’-基)-5-亚氨基-13-脱氧蒽环及制备方法 Expired - Fee Related CN110573165B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/434,617 US10450340B2 (en) 2017-02-16 2017-02-16 3′-deamino-3′-(2″-pyrroline-1″-yl)-5-imino-13-deoxyanthracyclines and methods of preparation
US15/434617 2017-02-16
PCT/US2018/000090 WO2018151872A1 (en) 2017-02-16 2018-02-16 3'deamino-3'-(2"-pyrroline-1"-yl)-5-imino-13-deoxyanthracyclines and methods of preparation

Publications (2)

Publication Number Publication Date
CN110573165A CN110573165A (zh) 2019-12-13
CN110573165B true CN110573165B (zh) 2023-07-11

Family

ID=61692048

Family Applications (1)

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CN201880025418.4A Expired - Fee Related CN110573165B (zh) 2017-02-16 2018-02-16 3’-脱氨基-3’-(2’’-吡咯啉-1’’-基)-5-亚氨基-13-脱氧蒽环及制备方法

Country Status (11)

Country Link
US (1) US10450340B2 (https=)
EP (1) EP3582788A1 (https=)
JP (1) JP7159177B2 (https=)
KR (1) KR20190117609A (https=)
CN (1) CN110573165B (https=)
AU (1) AU2018220520A1 (https=)
BR (1) BR112019017166A2 (https=)
CA (1) CA3053417A1 (https=)
IL (1) IL268680B (https=)
MX (1) MX388090B (https=)
WO (1) WO2018151872A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
CN1299366A (zh) * 1998-03-03 2001-06-13 杰姆药物股份有限公司 5－亚氨基－13－脱氧蒽环素衍生物,其用途及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
US7244829B2 (en) 2004-11-08 2007-07-17 Gem Pharmaceuticals, Llc Compositions and processes for preparing 13-deoxy-anthracyclines
JP2007261976A (ja) 2006-03-28 2007-10-11 Meiji Seika Kaisha Ltd 抗腫瘍性アンスラサイクリン系抗生物質の製造法
US7776832B2 (en) 2006-04-21 2010-08-17 Gem Pharmaceuticals, Llc Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines
US9904704B2 (en) 2014-04-22 2018-02-27 Openx Software Limited System and method for controlling audience data and tracking

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
CN1299366A (zh) * 1998-03-03 2001-06-13 杰姆药物股份有限公司 5－亚氨基－13－脱氧蒽环素衍生物,其用途及其制备方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin;Jana Stepankova等;《Biochemical Pharmacology》;20111231(第82期);第227-235页 *
Regression of rat Dunning R-3327-H prostate carcinoma by treatment with targeted cytotoxic analog of luteinizing hormone-releasing hormone AN-207 containing 2-pyrrolinodoxorubicin;Jungwirth A等;《International Journal of Oncology》;19971231;第10卷(第5期);第877-884页 *
Targeting of Cytotoxic Somatostatin Analog AN-238 to Somatostatin Receptor Subtypes 5 and/or 3 in Experimental Pancreatic Cancers;Karoly Szepeshazi等;《Clinical Cancer Research》;20010930;第7卷;第2854-2861页 *

Also Published As

Publication number Publication date
MX388090B (es) 2025-03-19
RU2019128837A3 (https=) 2021-06-17
BR112019017166A2 (pt) 2020-04-14
US20180230175A1 (en) 2018-08-16
MX2019009733A (es) 2020-02-07
AU2018220520A1 (en) 2019-09-05
CN110573165A (zh) 2019-12-13
CA3053417A1 (en) 2018-08-23
EP3582788A1 (en) 2019-12-25
JP7159177B2 (ja) 2022-10-24
JP2020507608A (ja) 2020-03-12
RU2019128837A (ru) 2021-03-16
KR20190117609A (ko) 2019-10-16
IL268680B (en) 2022-02-01
IL268680A (en) 2019-10-31
US10450340B2 (en) 2019-10-22
WO2018151872A1 (en) 2018-08-23

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