KR20190107166A - 암 치료 시스템, 방법 및 제형 - Google Patents

암 치료 시스템, 방법 및 제형 Download PDF

Info

Publication number
KR20190107166A
KR20190107166A KR1020197026111A KR20197026111A KR20190107166A KR 20190107166 A KR20190107166 A KR 20190107166A KR 1020197026111 A KR1020197026111 A KR 1020197026111A KR 20197026111 A KR20197026111 A KR 20197026111A KR 20190107166 A KR20190107166 A KR 20190107166A
Authority
KR
South Korea
Prior art keywords
pharmaceutical formulation
epigenetic
administering
quercetin
spb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020197026111A
Other languages
English (en)
Korean (ko)
Inventor
엠디 모하메드 네자미
Original Assignee
리서치 캔서 인스티튜트 오브 아메리카
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 리서치 캔서 인스티튜트 오브 아메리카 filed Critical 리서치 캔서 인스티튜트 오브 아메리카
Publication of KR20190107166A publication Critical patent/KR20190107166A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Inorganic Chemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1020197026111A 2011-07-07 2012-07-06 암 치료 시스템, 방법 및 제형 Withdrawn KR20190107166A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161505393P 2011-07-07 2011-07-07
US61/505,393 2011-07-07
US201161507950P 2011-07-14 2011-07-14
US61/507,950 2011-07-14
PCT/US2012/045821 WO2013006821A1 (en) 2011-07-07 2012-07-06 Systems, methods, and formulations for treating cancer

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147003161A Division KR102020939B1 (ko) 2011-07-07 2012-07-06 암 치료 시스템, 방법 및 제형

Publications (1)

Publication Number Publication Date
KR20190107166A true KR20190107166A (ko) 2019-09-18

Family

ID=47437478

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020197026111A Withdrawn KR20190107166A (ko) 2011-07-07 2012-07-06 암 치료 시스템, 방법 및 제형
KR1020147003161A Active KR102020939B1 (ko) 2011-07-07 2012-07-06 암 치료 시스템, 방법 및 제형

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020147003161A Active KR102020939B1 (ko) 2011-07-07 2012-07-06 암 치료 시스템, 방법 및 제형

Country Status (13)

Country Link
US (3) US20130011488A1 (enExample)
EP (2) EP2729008B1 (enExample)
JP (3) JP6082737B2 (enExample)
KR (2) KR20190107166A (enExample)
CN (2) CN103796514A (enExample)
AU (2) AU2012278813B2 (enExample)
CA (1) CA2839727C (enExample)
ES (1) ES2630306T3 (enExample)
IN (1) IN2014DN00195A (enExample)
MX (1) MX354383B (enExample)
PL (1) PL2729008T3 (enExample)
RU (1) RU2644635C2 (enExample)
WO (1) WO2013006821A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8933078B2 (en) 2011-07-14 2015-01-13 Research Cancer Institute Of America Method of treating cancer with combinations of histone deacetylase inhibitors (HDAC1) substances
US20140363523A1 (en) * 2012-01-18 2014-12-11 Concert Pharmaceuticals, Inc. Deuterated alpha-lipoic acid
CN103877066B (zh) * 2014-02-21 2016-08-24 中国人民解放军第二军医大学 载多西他赛和莱菔硫烷的自组装纳米粒的制备方法与应用
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
WO2018157081A1 (en) * 2017-02-27 2018-08-30 Research Cancer Institute Of America Compositions, methods, systems and/or kits for preventing and/or treating neoplasms
US11369585B2 (en) * 2017-03-17 2022-06-28 Research Cancer Institute Of America Compositions, methods, systems and/or kits for preventing and/or treating neoplasms
EP3691632B1 (en) * 2017-10-06 2025-01-01 Research Cancer Institute of America Compositions, methods, systems and/or kits for preventing and/or treating neoplasms
US12213958B2 (en) 2017-11-17 2025-02-04 Research Cancer Institute Of America Compositions, methods, systems and/or kits for preventing and/or treating neoplasms
WO2020061254A1 (en) * 2018-09-19 2020-03-26 Virginia Tech Intellectual Properties, Inc. Brca1 modulating compounds, formulations thereof, and uses thereof
US20230008508A1 (en) * 2019-12-10 2023-01-12 H. Lee Moffitt Cancer Center And Research Institute, Inc. Combination therapies for the treatment of cancer
CN112336716A (zh) * 2020-11-25 2021-02-09 四川大学华西医院 维生素c和双硫仑在制备抗肿瘤联合用药物中的用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4569836A (en) * 1981-08-27 1986-02-11 Gordon Robert T Cancer treatment by intracellular hyperthermia
JP2514500B2 (ja) * 1991-09-14 1996-07-10 呉羽化学工業株式会社 多剤耐性抑制剤及び発現阻害剤
DE69719320T2 (de) * 1996-06-11 2003-12-11 Novartis Ag, Basel Kombination eines somatostatin analogs und eines rapamycins
US5865722A (en) 1997-04-04 1999-02-02 Numotech, Incorporated Shape-adaptable topical hyperbaric oxygen chamber
US6299925B1 (en) * 1999-06-29 2001-10-09 Xel Herbaceuticals, Inc. Effervescent green tea extract formulation
US6376525B1 (en) * 2000-09-15 2002-04-23 Qingzhong Kong Method and composition for treating cancer using cellular organelle crystallizing agents
WO2002049501A2 (en) * 2000-12-18 2002-06-27 Board Of Regents, University Of Texas System Local regional chemotherapy and radiotherapy using in situ hydrogel
WO2003012085A1 (en) * 2001-07-30 2003-02-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Antigen presenting cells, method for their preparation and their use for cancer vaccines
US7435725B2 (en) * 2001-11-06 2008-10-14 The Quigly Corporation Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20030105104A1 (en) * 2001-11-27 2003-06-05 Burzynski Stanislaw R. Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy
US6572897B1 (en) * 2002-07-03 2003-06-03 Vitacost.Com, Inc. Insulin sensitivity maintenance and blood sugar level maintenance formulation for the prevention and treatment of diabetes
JP2007504131A (ja) * 2003-08-29 2007-03-01 エートン ファーマ インコーポレーティッド 癌の組み合わせ処置法
EP1571225A1 (en) * 2004-03-02 2005-09-07 PrimaGen Holding B.V. Diagnosis of a disease and monitoring of therapy using the AC133 gene
WO2006059237A1 (en) * 2004-08-30 2006-06-08 Lunamed, Inc. 4-phenylbutyric acid controlled-release formulations for therapeutic use
JP2006298781A (ja) * 2005-04-15 2006-11-02 Geno Membrane:Kk エストロン３硫酸トランスポーター活性阻害剤
ES2444890T3 (es) * 2006-03-31 2014-02-27 Erasmus University Medical Center Rotterdam Nueva composición para el control del crecimiento tumoral
EP1847274A1 (en) * 2006-04-21 2007-10-24 CIPROSA LLC - Corporate Creations Network, Inc. Association of phenylbutyrate, ATRA and cytidine and its use in anti-tumour therapy
US7745486B2 (en) * 2006-07-17 2010-06-29 Quercegen Pharma Llc Quercetin-containing compositions
PT2099442E (pt) * 2006-12-26 2015-02-10 Pharmacyclics Inc Métodos de utilização de inibidores de histona desacetilase e monitorização de biomarcadores em terapia de combinação
US20080305096A1 (en) * 2007-06-07 2008-12-11 Unicity International, Inc. Method and composition for providing controlled delivery of biologically active substances
US20110104100A1 (en) * 2007-10-04 2011-05-05 Medistem Laboratories, Inc. Compositions and methods of stem cell therapy for autism
US8394377B2 (en) * 2008-02-21 2013-03-12 The Regents Of The University Of Colorado Methods for treating cancer using combination therapy
EP2306996A1 (en) * 2008-07-18 2011-04-13 Novartis AG Use of hdac inhibitors for the treatment of hodgkin's disease
US20100316733A1 (en) * 2009-06-15 2010-12-16 Locklear Kenneth R Hyperbaric Oxygen Therapy and Treatment Method

Also Published As

Publication number Publication date
EP3326625A1 (en) 2018-05-30
EP2729008B1 (en) 2017-04-05
CN109675041A (zh) 2019-04-26
CA2839727A1 (en) 2013-01-10
JP2017105797A (ja) 2017-06-15
KR102020939B1 (ko) 2019-09-11
ES2630306T3 (es) 2017-08-21
MX2014000150A (es) 2014-05-14
US20170014376A1 (en) 2017-01-19
JP6082737B2 (ja) 2017-02-15
PL2729008T3 (pl) 2017-10-31
JP2014518274A (ja) 2014-07-28
US20200206183A1 (en) 2020-07-02
MX354383B (es) 2018-03-02
RU2644635C2 (ru) 2018-02-13
KR20140076546A (ko) 2014-06-20
JP2018203767A (ja) 2018-12-27
CA2839727C (en) 2023-10-17
US20130011488A1 (en) 2013-01-10
CN103796514A (zh) 2014-05-14
RU2014101261A (ru) 2015-08-20
IN2014DN00195A (enExample) 2015-06-05
AU2012278813B2 (en) 2016-09-08
AU2016269491B2 (en) 2018-08-30
WO2013006821A1 (en) 2013-01-10
JP6401317B2 (ja) 2018-10-10
EP2729008A1 (en) 2014-05-14
AU2012278813A1 (en) 2014-01-30
EP2729008A4 (en) 2014-10-29
AU2016269491A1 (en) 2017-01-05

Similar Documents

Publication Publication Date Title
KR102020939B1 (ko) 암 치료 시스템, 방법 및 제형
KR102011641B1 (ko) 치환된 퀴나졸리논을 위한 경구 즉시 방출 제형
US12042483B2 (en) Prophylactic and therapeutic drug for nonalcoholic fatty liver disease
US20190167634A1 (en) Method of treating cancer with combinations of histone deacetylase inhibitors (hdac1) substances
JP2021169534A (ja) 化学療法の改善
CN102552908B (zh) 含青蒿素及青蒿素类衍生物和Bcl-2抑制剂的药物组合物及其应用
CN102441168B (zh) 含芹菜素及芹菜素类衍生物和Bcl-2抑制剂的药物组合物及其在制备治疗癌症的药物中的应用
KR101695801B1 (ko) 운동 뉴런의 자가 포식 작용 억제를 위한 약학적 조성물 및 이의 용도
WO2014047782A1 (zh) 含有白藜芦醇及白藜芦醇类衍生物和Bcl-2抑制剂的药物组合物及其应用
CN114306366A (zh) 含nad和cd38抑制剂的药物组合物及其用途
WO2011143590A1 (en) Combination therapy compositions and methods using lipoic acid derivatives and an anti-proliferation agent
CN102440987B (zh) 含有芹菜素及芹菜素类衍生物和青蒿素及青蒿素类衍生物的药物组合物及其应用
CN102292081A (zh) 包含硫辛酸和羟基柠檬酸作为活性成分的药物联用物
JP2008509877A (ja) 通常、ビタミンｃ、マグネシウム、緑茶抽出物を含む心血管系疾患を抑制するための医薬調合物
AU2015101671A4 (en) Combination therapy comprising a PI3, AKT kinase or mTOR inhibitors
EP3265086A1 (en) A lysosomal inhibitor and a multikinase inhibitor in the treatment of liver cancer

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20190905

Application number text: 1020147003161

Filing date: 20140206

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid