KR20190090255A - Cosmetic composition for preventing hair loss containing arctium lappa seed extract, niacinamide and methyl pca - Google Patents

Abstract

The present invention relates to a cosmetic composition for preventing hair loss, comprising an Arctium lappa seed extract, niacinamide and menthyl PCA as an active ingredient; and a manufacturing method thereof. The present invention relates to a hair care product composition for preventing hair loss, which prevents hair loss and protects the scalp without reducing the intrinsic function of hair care products while stimulating the blood circulation of the scalp to promote hair growth.

Description

{COSMETIC COMPOSITION FOR PREVENTING HAIR LOSS CONTAINING ARCTIUM LAPPA SEED EXTRACT, NIACINAMIDE AND METHYL PCA}

The present invention relates to a cosmetic composition for preventing hair loss, which comprises an extract of Ubija, niacinamide and menthyl picosene. More specifically, the present invention relates to a cosmetic composition for hair loss such as a hair shampoo, a hair conditioner or hair essence including a wisteria extract, niacinamide, ≪ / RTI >

The symptoms of hair loss are increasing in various age groups and women due to various factors such as environmental factors and social factors due to the development of society. Such hair loss phenomenon is caused by environmental and social factors. Especially, due to frequent perms, dyeing, stress, severe diet, etc., the symptom incidence is increasing not only in men but also in women. have.

The scalp fundamentally has all of the organs in the body to protect against external forces such as mechanical external forces, chemical poisoning, microbial invasion, sunshine, and absorption, respiration and excretion, and sensory functions. These scalp excretes harmful substances and waste materials in the body. When the keratin and waste materials mixed with sebum in the scalp accumulate on the surface, they block the scalp pores, prevent skin respiration, cause inflammation in the scalp, do. If the skin is not breathing smoothly, it accumulates in the body and eventually disturbs the balance of the body.

In general, soap or shampoo is generally used for washing hair. Especially, in recent years, interest of general consumers' hair is increased, so that not only simple washing but also functional shampoo for preventing hair loss through health of scalp and hair The development of the In addition, it is important to develop a healthy shampoo that is useful for life when occupying more than 70% of hair cosmetics such as shampoo in real life, and occupying more than 80% when including non-medical cosmetics.

Many researches have been conducted on hair loss prevention shampoos using herbal extracts. However, most of them have improved functionality for hair loss or hair growth, so that the cleaning function, which is a basic function of shampoo, is inferior, Or hair loss, even if the effect of the actual herbal ingredients is too strong, the smell of a powerful smell or shampoo after the hair becomes stiff because the phenomenon occurs, many consumers can not satisfy the taste.

Korean Patent Registration No. 10-1310970 discloses a hair cosmetic composition comprising a first hair loss prevention herbal extract comprising rosewood, yellowish white, gold and the like, and a second hair loss prevention herbal extract containing a right wing, windshield and the like.

It is an object of the present invention to prevent hair loss by mixing hair extracts, niacinamide and menthyl pith, without reducing the inherent functions of hair products such as shampoos, hair conditioners or hair essences, and at the same time stimulating the blood circulation of the scalp And to provide a hair cosmetic composition which promotes hair growth.

The present invention relates to a cosmetic composition for preventing hair loss, which comprises the extract of Ubija, niacinamide and menthyl pic.

Preferably, the fragrance extract is contained in an amount of 0.0001 to 30.0% by weight based on the total weight of the cosmetic composition, the niacinamide is contained in an amount of 0.01 to 10.0% by weight based on the total weight of the cosmetic composition, By weight based on 100% by weight of the total composition.

Preferably, the cosmetic composition promotes hair growth to prevent hair loss.

The cosmetic composition for prevention of hair loss, which contains the extract of the present invention, niacinamide and menthyl picicolate according to the present invention is improved in blood circulation around the scalp and hair root to prevent hair loss and at the same time keep scalp healthy and provide nutrients Thereby promoting hair growth.

In addition, according to the cosmetic composition containing the alopecia extract for preventing alopecia of the present invention, niacinamide and menthyl picosapentaenoic acid, since hair materials derived from natural materials are mainly used, the stimulation of the scalp is alleviated more than the conventional hair products, It is possible to exert an excellent effect in preventing hair loss, promoting scalp healing, and promoting hair growth. Particularly, the addition of the extract of the extract of the present invention improves blood circulation around the scalp and hair root to prevent hair loss, And it has an excellent effect of promoting hair growth by providing nutrients to the hair.

Unless defined otherwise, all technical terms used in the present invention have the following definitions and are consistent with the meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. In addition, preferred methods or samples are described in this specification, but similar or equivalent ones are also included in the scope of the present invention. The contents of all publications referred to herein are incorporated herein by reference. The term " drug " is used herein to refer to a reference quantity, level, value, number, frequency, percentage, dimension, size, quantity, Level, value, number, frequency, percentage, dimension, size, quantity, weight or length of a sample,

Throughout this specification, the words "comprises" and "comprising ", unless the context requires otherwise, include the steps or components, or groups of steps or elements, Steps, or groups of elements are not excluded.

The present invention relates to a cosmetic composition for preventing hair loss, which comprises the extract of Ubija, niacinamide and menthyl pic.

Allium is a plant belonging to the Compositae family. It is native to Korea, Japan and China. Arctii Fructus, Arctium lappa seed) refers to the fruit of a friend. The main component of the stranger is known as lignan, arctigenin, and arctinin as a lignan glycoside (T. Namba, The encyclopedia of Wakan-Yaku with Colors Pictures, Vol I, pp208, Hoikusha, Tokyo, 1993 ), And it is used for various kinds of tumors and poisonous poison (poisonous poison).

In the present invention, the term "right-wing-head extract" refers to an extract obtained by extracting from a right wing.

In addition, the present invention's ubiquitin extract may be prepared according to conventional methods known in the art, that is, under the conditions of ordinary temperature and pressure, using a conventional solvent. The extract of UAV is preferably selected from the group consisting of (a) water, anhydrous or lower alcohol having 1 to 4 carbon atoms (for example, methanol, ethanol, propanol and butanol), propylene glycol, 1,3-butylene glycol, glycerin, Solvent extraction using a solvent selected from the group consisting of diethyl ether, ethyl acetate, butyl acetate, dichloromethane, chloroform, hexane, and mixtures thereof, (b) supercritical extraction with reduced pressure by carbon dioxide, Means extraction using an ultrasonic extraction method.

In the present invention, a solvent extraction method using an extraction solvent is preferably used. In the present invention, the outdresser extract may contain various extraction solvents, for example, water, anhydrous or lower alcohols having 1-4 carbon atoms (e.g., methanol, ethanol, propanol and butanol), propylene glycol, And at least one extraction solvent selected from the group consisting of glycerin, acetone, diethyl ether, ethyl acetate, butyl acetate, dichloromethane, chloroform, hexane and mixtures thereof. (v / v) ethanol or water, and most preferably 70% (v / v) ethanol.

On the other hand, it is obvious to those skilled in the art that the extract of the present invention can be obtained not only by the above-mentioned extraction solvent but also by using other extraction solvent, which exhibits substantially the same effect.

In addition, the UAV extract of the present invention includes not only the extract obtained by the above-mentioned extraction solvent, but also the extract obtained through ordinary purification and fermentation process. For example, decompression by carbon dioxide, extraction by supercritical extraction with high temperature, extraction by extraction using ultrasound, separation by ultrafiltration membrane with constant molecular weight cutoff value, various chromatography (size, charge, hydrophobic or affinity The active fractions obtained by various purification and extraction methods, such as those obtained by separating them according to sex, or extracts from fermentation products using natural or various microorganisms, are also included in the extract of the present invention. In addition, the extract of the present invention includes a liquid substance obtained by cold filtration and heat filtration of the extract at room temperature.

The supercritical fluid extraction refers to supercritical fluid extraction. Generally, the supercritical fluid is extracted from the liquid and the gas when the gas reaches the critical point at high temperature and high pressure. Gas properties and has chemically similar polarity to nonpolar solvents. Due to these properties, supercritical fluids have been used to extract lipophilic substances (J. Chromatogr. A. 1998; 479: 200-205). Carbon dioxide is a supercritical fluid with both liquid and gaseous nature, with the operation of supercritical fluid equipment reaching its critical pressure and temperature, resulting in increased solubility in fat-soluble solutes. When supercritical carbon dioxide passes through an extraction vessel containing a certain amount of sample, the lipophilic substance contained in the sample is extracted into supercritical carbon dioxide. When the supernatant carbon dioxide containing a small amount of cosolvent is passed through the sample remaining in the extraction vessel after extracting the lipid-soluble substance, components that were not extracted by pure supercritical carbon dioxide can be extracted.

The supercritical fluid used in the supercritical extraction method of the present invention can effectively extract an active ingredient by using a mixed fluid in which a cosolvent is further mixed with supercritical carbon dioxide or carbon dioxide. These co-solvents may be used alone or in admixture of two or more selected from the group consisting of chloroform, ethanol, methanol, water, ethyl acetate, hexane and diethyl ether. Most of the extracted samples contain carbon dioxide. Since the carbon dioxide is volatilized into air at room temperature, the extract obtained by the above method can be used as a cosmetic composition, and the cosolvent can be removed by a reduced pressure evaporator.

In addition, the ultrasonic extraction method is an extraction method using energy generated by ultrasonic vibration. Ultrasonic waves can destroy an insoluble solvent contained in a sample in a water-soluble solvent. Due to the high local temperature generated at this time, Since the kinetic energy of the particles is increased, sufficient energy required for the reaction is obtained. By inducing the high pressure by the shock effect of the ultrasonic energy, the mixing efficiency of the substance contained in the sample and the solvent is increased, thereby increasing the extraction efficiency. As the extraction solvent which can be used for the ultrasonic extraction method, one or a mixture of two or more selected from the group consisting of chloroform, ethanol, methanol, water, ethyl acetate, hexane and diethyl ether can be used. The extracted sample is recovered by vacuum filtration, and the filtrate is recovered, and the extract is removed by a vacuum evaporator and freeze-dried to obtain an extract.

The extract according to the present invention also includes an extract obtained through a fermentation process. The fermented extract of the recipient can be prepared as follows. The fragile material is finely crushed to about 100 to 500 mesh, then 1 to 50 g / L of a conventional microorganism culture solution is added, and microorganisms such as yeast or lactic acid bacteria are added in an amount of 10,000 to 100,000 cfu / L. The culture temperature is 30 to 37 ° C. The pH is 5 to 7 and aerobic or anaerobic conditions are maintained for about 5 to 10 days. Which can be obtained through aging and filtration.

According to the present invention, it is preferable that the above-mentioned outpatient extract is contained in an amount of 0.0001 to 30.0% by weight based on the total weight of the cosmetic composition, and more preferably, the above-mentioned outpatient extract is contained in an amount of 0.01 to 10% do. When the content of the extract is less than 0.0001% by weight, the effect of improving the skin is not exhibited. When the content of the extract is more than 30.0% by weight, the degree of improvement of the skin against the increase of the content is insignificant, It is not even.

The cosmetic composition according to the present invention contains Niacinamide (C ₆ H ₆ N ₂ O). The niacinamide may be contained in an amount of 0.01 to 10.0% by weight based on the total weight of the cosmetic composition. When the niacinamide is contained in an amount of less than 0.01% by weight, there is a problem that the substantial increase in the effect is insignificant. When the content exceeds 10.0% by weight, there is a problem in the skin irritation.

In addition, the cosmetic composition according to the present invention contains menthyl PCA (Menthyl pyrrolidone carboxylate, C ₁₅ H ₂₅ NO ₃ ). The menthyl peroxide may be contained in an amount of 0.001 to 2.0% by weight based on the total weight of the cosmetic composition. When it is contained in an amount of less than 0.001% by weight, a substantial increase in the effect is insignificant. When the content is more than 2.0% by weight, there is a problem of skin irritation.

The ingredients contained in the cosmetic composition of the present invention may contain, as an active ingredient, the ingredients commonly used in the cosmetic composition for hair in addition to the above-mentioned effective ingredients, and may contain various additives such as antioxidants, stabilizers, solubilizers, vitamins, A conventional adjuvant, and a carrier.

The hair cosmetic compositions of the present invention may be prepared in any form conventionally produced in the art and may be formulated into various forms such as solutions, suspensions, emulsions, pastes, gels, creams, lotions, surfactant- A hair massage cream, a spray, and the like. However, the present invention is not limited thereto. More specifically, it can be applied to hair tonic, hair nutrition water, hair massage cream, hair, hair cleansing water, pack, spray or hair shampoo and the like.

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide ether Alkylamido betaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, or ethoxylated glycerol fatty acid ester.

When the cosmetic composition of the present invention is a surfactant-containing cleansing formulation or a surfactant-free cleansing formulation, it may be applied to hair and then wiped off, washed or rinsed with water. The surfactant-containing cleansing formulation is a cleansing foam, a cleansing water, a cleansing towel, and a cleansing pack. The surfactant-free cleansing formulation is not limited to a cleansing cream, a cleansing lotion, a cleansing water and a cleansing gel.

On the other hand, the cosmetic process of the present invention refers to all cosmetic processes using the cosmetic composition of the present invention. That is, all methods known in the art using a cosmetic composition belong to the cosmetic method of the present invention. The cosmetic composition of the present invention may be used alone or in combination, or may be used in combination with other cosmetic compositions other than the present invention. The cosmetic composition according to the present invention may be used according to a conventional method of use, and may be used in a number of times depending on the skin condition or taste of the user.

By carrying out the cosmetic method using the cosmetic composition containing the extract of the present invention, niacinamide and menthylpicide of the present invention, blood clotting is assisted and hair loss prevention effect can be obtained.

The cosmetic composition for prevention of hair loss, which contains the extract of the present invention, niacinamide and menthyl picetate, can enhance the activation of dermal papilla cells and increase blood circulation, thereby giving excellent effects to prevent hair loss.

These embodiments are only for describing the present invention in more detail, and the scope of the present invention is not limited by these embodiments in accordance with the gist of the present invention.

[ Manufacturing example  One] Supercritical  Using fluid extraction Warder  Preparation of extract

The supernatant was washed with purified water, dried and crushed into small pieces, and 1 g of the sample was placed in a supercritical fluid extractor (Jasco, Japan) and analyzed with a liquid chromatography pump (Supercritical fluid chromatograph, Jasco, Japan) The extract was poured into a supercritical state at a temperature of 60 ° C and a pressure of 300 at a temperature of 40 ° C for 4 minutes. The extract was dried with a rotary evaporator to obtain a dry weight of 39 mg / g. The dried stratum corneum powder was dissolved in 50% 1,3-butylene glycol and used.

[ Example  1 and Comparative Example  1 to 2]

Example 1 and Comparative Examples 1 and 2 were formulated into shampoo compositions having the compositions shown in Table 1 below.

Comparative Example 1 Comparative Example 2 Example 1 Purified water Balance Balance Balance Ammonium laureth sulfate 13.00 13.00 13.00 Ammonium lauryl sulfate 4.00 4.00 4.00 Dimethicone 2.60 2.60 2.60 Glycol distearate 2.00 2.00 2.00 Cocamide miai 1.00 1.00 1.00 Panthenol 0.10 0.10 0.10 Salicylic acid 0.10 0.10 0.10 Cetyl alcohol 0.60 0.60 0.60 Sodium chloride 0.55 0.55 0.55 Polyquaternium-10 0.31 0.31 0.31 Hydrogenated polydecene 0.20 0.20 0.20 Monte Neil 0.20 0.20 0.20 p-no formula 0.10 0.10 0.10 glycerin 0.03 0.03 0.03 Cocamidopropyl betaine 0.03 0.03 0.03 C12-15 pares-3 0.03 0.03 0.03 Spices Suitable amount Suitable amount Suitable amount Disodium iodide 0.10 0.10 0.10 Warder  Extract Manufacturing example  One) - 5.00 5.00 Niacinamide - 1.0 1.0 Mentyl PCA - - 0.2 Total amount 100.00 100.00 100.00

[ Experimental Example  1] Sensory evaluation

Dandruff and scalp itching were divided into first to third groups of 25 persons each, including 10 persons, and 25 persons belonging to the first group were divided into three groups according to the present invention, i.e., a weevil extract, niacinamide and menthylpiperidine Hair shampoo (Example 1) was allowed to use for 7 weeks (45 days), 25 persons belonging to the second group were given a hair shampoo (Comparative Example 1) which did not contain the extract of Wisteria, niacinamide and menthyl picolinate, Twenty-five of the third group were allowed to use a hair shampoo (Comparative Example 2) containing the extract of Weifeng and niacinamide for 7 weeks (45 days). The state changes of the results are shown in Table 2 below.

division State change The first group
(Comparative Example 1) The second group
(Comparative Example 2) Group 3
(Example 1) Hair condition Very good - 2 17 good 6 6 5 No change 19 17 3 Hair Nutrition Very good - 3 18 good 5 5 5 No change 20 17 2 Scalp condition Very good One 3 17 good 3 3 6 No change 21 19 2

In the above evaluation, in the case of the hair growth state, there is a hair growth symptom in the whole head, and if there is an increase in the number of hair, it is 'very good'. If there is hair growth in a part of the head, When there was no symptom, 'no change' was made. In the case of hair nutrition, there is almost no damage to the hair and it is smooth. It is very good when it is abundant as a whole. When the hair damage is limited to a part, it is good when the hair is smooth, No change '. In case of scalp state, there is no irritation in the whole scalp, no itching, 'very good' when the scalp is clean, 'good' when the sebum or itching is partially improved, 'No change'.

As shown in the above Table 2, when the composition for hair restraint hair restraint (Example 1) containing the fragrant extract, niacinamide and menthyl pion is continuously used, the hair loss rate reduction effect is shown to 68% or more users And all users had the effect of preventing hair loss and thick hair and fine hair. In addition, hair nutritional status was mostly good and more than 72%. The condition of the scalp was mostly improved, and it can be seen that 68% or more of the users got a good evaluation.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the same is by way of illustration and example only and is not to be construed as limiting the scope of the present invention. It is therefore intended that the scope of the invention be defined by the claims appended hereto and their equivalents.

Claims (3)

Hair extract, niacinamide and menthyl picolinate. The method according to claim 1,
The above-mentioned extract is contained in an amount of 0.0001 to 30.0% by weight based on the total weight of the cosmetic composition, the niacinamide is contained in an amount of 0.01 to 10.0% by weight based on the total weight of the cosmetic composition, 2.0% by weight based on the total weight of the cosmetic composition. The method according to claim 1,
Wherein the cosmetic composition promotes hair growth to prevent hair loss.