KR20190077095A - 줄기 세포 유래 슈반 세포 - Google Patents
줄기 세포 유래 슈반 세포 Download PDFInfo
- Publication number
- KR20190077095A KR20190077095A KR1020197017089A KR20197017089A KR20190077095A KR 20190077095 A KR20190077095 A KR 20190077095A KR 1020197017089 A KR1020197017089 A KR 1020197017089A KR 20197017089 A KR20197017089 A KR 20197017089A KR 20190077095 A KR20190077095 A KR 20190077095A
- Authority
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- South Korea
- Prior art keywords
- days
- cell
- population
- cells
- schwann cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/08—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662421816P | 2016-11-14 | 2016-11-14 | |
| US62/421,816 | 2016-11-14 | ||
| PCT/US2017/061541 WO2018090002A1 (en) | 2016-11-14 | 2017-11-14 | Stem cell derived schwann cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20190077095A true KR20190077095A (ko) | 2019-07-02 |
Family
ID=62110088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197017089A Ceased KR20190077095A (ko) | 2016-11-14 | 2017-11-14 | 줄기 세포 유래 슈반 세포 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190331666A1 (https=) |
| EP (2) | EP3538115A4 (https=) |
| JP (4) | JP2019535263A (https=) |
| KR (1) | KR20190077095A (https=) |
| CN (2) | CN110249047A (https=) |
| AU (2) | AU2017357076A1 (https=) |
| CA (2) | CA3043226A1 (https=) |
| IL (2) | IL266524A (https=) |
| WO (2) | WO2018090006A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL272246B2 (en) | 2017-07-28 | 2026-01-01 | Applied Therapeutics Inc | History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications |
| US11511136B2 (en) * | 2017-11-17 | 2022-11-29 | The Research Foundation For The State University Of New York | Method for treating damaged peripheral nerves using x-ray microbeam irradiation |
| CA3084259A1 (en) * | 2017-12-04 | 2019-06-13 | The Administrators Of The Tulane Educational Fund | Cell systems using spheroids and methods of making and using the same |
| US11845989B2 (en) | 2019-01-23 | 2023-12-19 | Regeneron Pharmaceuticals, Inc. | Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors |
| MX2021008797A (es) | 2019-01-23 | 2022-01-31 | Regeneron Pharma | Tratamiento de afecciones oftalmicas con inhibidores de proteinas relacionadas a angiopoyetina 7 (angptl7). |
| CA3132136A1 (en) | 2019-04-01 | 2020-10-08 | Andrew Wasmuth | Inhibitors of aldose reductase |
| JP2022531466A (ja) | 2019-05-07 | 2022-07-06 | ユニバーシティ オブ マイアミ | 遺伝性ニューロパチーおよび関連障害の処置および検出 |
| CN110157660A (zh) * | 2019-06-10 | 2019-08-23 | 西安飞如生物科技有限公司 | 诱导成纤维细胞分泌抗菌肽的诱导培养基和方法、成纤维细胞及应用 |
| JPWO2021166984A1 (https=) * | 2020-02-20 | 2021-08-26 | ||
| EP3929281A1 (en) | 2020-06-24 | 2021-12-29 | Fachhochschule Technikum Wien | Cell construct comprising schwann cells or schwann cell-like cells and a biocompatible matrix |
| US11865134B2 (en) | 2021-02-26 | 2024-01-09 | Regeneron Pharmaceuticals, Inc. | Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (ANGPTL7) inhibitors |
| EP4355864A4 (en) * | 2021-06-18 | 2025-04-23 | Memorial Sloan Kettering Cancer Center | Methods of generating sacral neural crest lineages and uses thereof |
| CA3265079A1 (en) * | 2022-08-16 | 2024-02-22 | The Regents Of The University Of California | CELLULAR COMPOSITIONS AND THEIR METHODS OF USE |
| WO2025170529A1 (en) | 2024-02-09 | 2025-08-14 | Hedlund Eva | A method for deriving a multipotent neuromesodermal progenitor cell and/or daughter lineages, and related compositions |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023568A2 (en) * | 1998-10-06 | 2000-04-27 | Albert Einstein College Of Medicine Of Yeshiva University | Methods and compositions for decreasing mitochondrial overproduction of reactive oxygen species in cells |
| CN101066472B (zh) * | 2007-04-18 | 2010-05-19 | 中国人民解放军第二军医大学 | 组织工程化周围神经移植体及其制备方法 |
| US8709805B2 (en) * | 2009-08-07 | 2014-04-29 | Kyoto University | Canine iPS cells and method of producing same |
| WO2011046189A1 (ja) * | 2009-10-15 | 2011-04-21 | 国立大学法人京都大学 | 神経変性疾患のモデル細胞、その製造方法及びその用途 |
| CN102191217A (zh) * | 2010-03-12 | 2011-09-21 | 上海市第一人民医院 | 一种诱导脐带间充质干细胞分化为类神经细胞的方法 |
| DK3578988T3 (da) * | 2010-05-25 | 2025-02-24 | Memorial Sloan Kettering Cancer Center | Fremgangsmåde til nociceptordifferentiering af humane embryonale stamceller og anvendelse heraf |
| BR112013008957A2 (pt) * | 2010-10-15 | 2019-09-24 | Univ Cornell | composições e métodos para tratamento de doenças endócrinas, gastrointestinais ou autoimunes |
| EP3502236B1 (en) * | 2011-02-18 | 2023-08-23 | The Scripps Research Institute | Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate |
| EP2614829A1 (en) * | 2012-01-11 | 2013-07-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons |
| KR20160033703A (ko) * | 2013-07-23 | 2016-03-28 | 에프. 호프만-라 로슈 아게 | 체세포로부터 신경 능선 세포로의 소분자 기반 전환 |
| WO2015017523A1 (en) * | 2013-07-30 | 2015-02-05 | Waters Technologies Corporation | Check valve having polymeric seat and poppet |
| GB201318126D0 (en) * | 2013-10-14 | 2013-11-27 | Univ Cardiff | Neuronal Stem Cell Differentiation |
| AU2014352773B2 (en) | 2013-11-21 | 2021-04-29 | Memorial Sloan-Kettering Cancer Center | Specification of functional cranial placode derivatives from human pluripotent stem cells |
| CN114657141B (zh) * | 2014-09-12 | 2025-02-25 | 京都府公立大学法人 | 雪旺氏细胞及其制备方法 |
| US20180140637A1 (en) * | 2015-05-19 | 2018-05-24 | Maya Sieber-Blum | Epidermal neural crest stem cells as a source of schwann cells |
| KR101903458B1 (ko) * | 2017-01-20 | 2018-10-02 | 한국생명공학연구원 | 슈반 세포 전구체 (Schwann cell precursor) 및 이로부터 분화된 슈반 세포 (Schwann cell)의 제조 방법 |
-
2017
- 2017-11-14 WO PCT/US2017/061549 patent/WO2018090006A1/en not_active Ceased
- 2017-11-14 CN CN201780083272.4A patent/CN110249047A/zh active Pending
- 2017-11-14 EP EP17870215.5A patent/EP3538115A4/en not_active Withdrawn
- 2017-11-14 WO PCT/US2017/061541 patent/WO2018090002A1/en not_active Ceased
- 2017-11-14 CN CN201780082987.8A patent/CN110691601A/zh active Pending
- 2017-11-14 EP EP17870058.9A patent/EP3538110A4/en not_active Withdrawn
- 2017-11-14 JP JP2019524940A patent/JP2019535263A/ja active Pending
- 2017-11-14 KR KR1020197017089A patent/KR20190077095A/ko not_active Ceased
- 2017-11-14 JP JP2019524951A patent/JP2019535265A/ja active Pending
- 2017-11-14 AU AU2017357076A patent/AU2017357076A1/en not_active Abandoned
- 2017-11-14 CA CA3043226A patent/CA3043226A1/en active Pending
- 2017-11-14 CA CA3043223A patent/CA3043223A1/en active Pending
- 2017-11-14 AU AU2017357072A patent/AU2017357072A1/en not_active Abandoned
-
2019
- 2019-05-08 IL IL266524A patent/IL266524A/en unknown
- 2019-05-12 IL IL266554A patent/IL266554A/en unknown
- 2019-05-13 US US16/410,763 patent/US20190331666A1/en not_active Abandoned
- 2019-05-13 US US16/410,686 patent/US20190264173A1/en active Pending
-
2022
- 2022-02-17 JP JP2022022796A patent/JP2022059056A/ja active Pending
- 2022-04-26 JP JP2022072292A patent/JP2022090133A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3043223A1 (en) | 2018-05-17 |
| CA3043226A1 (en) | 2018-05-17 |
| US20190331666A1 (en) | 2019-10-31 |
| EP3538115A4 (en) | 2020-04-22 |
| EP3538115A1 (en) | 2019-09-18 |
| WO2018090002A1 (en) | 2018-05-17 |
| EP3538110A1 (en) | 2019-09-18 |
| CN110249047A (zh) | 2019-09-17 |
| CN110691601A (zh) | 2020-01-14 |
| JP2022059056A (ja) | 2022-04-12 |
| AU2017357076A1 (en) | 2019-05-30 |
| JP2019535263A (ja) | 2019-12-12 |
| US20190264173A1 (en) | 2019-08-29 |
| WO2018090006A1 (en) | 2018-05-17 |
| IL266554A (en) | 2019-07-31 |
| JP2019535265A (ja) | 2019-12-12 |
| JP2022090133A (ja) | 2022-06-16 |
| EP3538110A4 (en) | 2020-04-22 |
| IL266524A (en) | 2019-07-31 |
| AU2017357072A1 (en) | 2019-05-30 |
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