KR20190025906A - 조작된 보툴리눔 신경독소 - Google Patents
조작된 보툴리눔 신경독소 Download PDFInfo
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- KR20190025906A KR20190025906A KR1020197000585A KR20197000585A KR20190025906A KR 20190025906 A KR20190025906 A KR 20190025906A KR 1020197000585 A KR1020197000585 A KR 1020197000585A KR 20197000585 A KR20197000585 A KR 20197000585A KR 20190025906 A KR20190025906 A KR 20190025906A
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| KR20190015240A (ko) * | 2016-05-16 | 2019-02-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 보툴리눔 신경독소의 정제 및 활성화 방법 |
| WO2024080682A1 (ko) * | 2022-10-12 | 2024-04-18 | 주식회사 알케미어 | 보툴리눔 독소의 경쇄 변이체 |
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| ES2847241T3 (es) | 2012-05-30 | 2021-08-02 | Harvard College | Neurotoxina botulínica genéticamente modificada |
| CN115925835A (zh) * | 2015-03-26 | 2023-04-07 | 哈佛大学校长及研究员协会 | 工程改造的肉毒杆菌神经毒素 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| TW201718627A (zh) * | 2015-06-11 | 2017-06-01 | 梅茲製藥有限兩合公司 | 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞 |
| GB201607901D0 (en) | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
| PL3481852T3 (pl) * | 2016-07-08 | 2023-07-24 | Children's Medical Center Corporation | Nowa neurotoksyna botulinowa i jej pochodne |
| US11117935B2 (en) | 2016-08-24 | 2021-09-14 | President And Fellows Of Harvard College | Engineered botulinum neurotoxin |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US12098169B2 (en) | 2017-09-29 | 2024-09-24 | Children's Medical Center Corporation | Enterococcus faecium neurotoxin (BoNT/EN) and derivatives thereof |
| TWI810228B (zh) * | 2017-12-20 | 2023-08-01 | 英商艾普森生物製藥有限公司 | 自主神經系統障礙之治療 |
| KR20200115584A (ko) | 2018-01-30 | 2020-10-07 | 칠드런'즈 메디컬 센터 코포레이션 | 바실루스 시스템을 이용한 보툴리눔 신경독소의 생산 |
| US11707510B2 (en) * | 2018-02-16 | 2023-07-25 | Preclinics Discovery Gmbh | Nucleic acid-based botulinum neurotoxin for therapeutic use |
| SE542539C2 (en) * | 2018-02-26 | 2020-06-02 | Toxotech Ab | Chimeric botulinum neurotoxin heavy chain binding domain |
| CN114957482B (zh) * | 2021-02-26 | 2024-09-24 | 重庆誉颜制药有限公司 | 一种经修饰的神经毒素的单链多肽及其用途 |
| KR20230001254A (ko) | 2021-06-28 | 2023-01-04 | (주)메디톡스 | 재조합 보툴리눔 독소 타입 a 경쇄, 재조합 보툴리눔 독소 및 이의 조성물, 용도 및 방법 |
| KR20230001260A (ko) | 2021-06-28 | 2023-01-04 | (주)메디톡스 | 재조합 보툴리눔 독소 타입 a 경쇄, 재조합 보툴리눔 독소 및 이의 조성물, 용도 및 방법 |
| WO2023068485A1 (ko) * | 2021-10-22 | 2023-04-27 | 비피메드(주) | 보툴리눔 유래 펩타이드를 포함하는 탈모개선용 조성물 |
| KR20240116485A (ko) * | 2021-11-22 | 2024-07-29 | 입센 바이오팜 리미티드 | 통증의 치료 |
| CN114369623B (zh) * | 2022-01-12 | 2023-07-07 | 中国人民解放军空军军医大学 | 一种基于Cre-lox重组系统的Synaptotagmin2-RNAi及其应用 |
| CN114410683B (zh) * | 2022-01-12 | 2023-11-28 | 中国人民解放军空军军医大学 | 一种基于Cre-lox重组系统的RIM3-RNAi及其应用 |
| GB202206348D0 (en) * | 2022-04-29 | 2022-06-15 | Ipsen Biopharm Ltd | Treatment of limb spasticity |
| WO2025065012A1 (en) * | 2023-09-21 | 2025-03-27 | The Medical College Of Wisconsin, Inc. | Botulinum neurotoxin variants, constructs, compositions, and methods of use |
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| GB201607901D0 (en) * | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190015240A (ko) * | 2016-05-16 | 2019-02-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 보툴리눔 신경독소의 정제 및 활성화 방법 |
| WO2024080682A1 (ko) * | 2022-10-12 | 2024-04-18 | 주식회사 알케미어 | 보툴리눔 독소의 경쇄 변이체 |
| KR102728382B1 (ko) * | 2022-10-12 | 2024-11-14 | 주식회사 알케미어 | 보툴리눔 독소의 경쇄 변이체 |
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| AU2017277905A1 (en) | 2018-12-20 |
| SG11201810210UA (en) | 2018-12-28 |
| SG10201912099TA (en) | 2020-02-27 |
| US11104891B2 (en) | 2021-08-31 |
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