KR20190018968A - 병원성 장내세균에 대해 사멸능을 갖는 신규 박테리오파지 및 이의 용도 - Google Patents
병원성 장내세균에 대해 사멸능을 갖는 신규 박테리오파지 및 이의 용도 Download PDFInfo
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Abstract
본 발명은 여시니아(Yersinia)속, 시겔라(Shigella)속 또는 대장균(Escherichia coli)에 속하는 장내 세균에 대해 사멸능을 갖는 신규한 박테리오파지(KFS-YE) 및 이의 용도에 관한 것이다. 본 발명의 박테리오파지는 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 및 대장균(Escherichia coli)에 대해 특이적인 증식 억제 또는 사멸능을 나타내므로, 상기 박테리오파지 또는 이의 배양물은 상기 균들에 의해 유발되는 질환의 예방 또는 치료용 약학적 조성물, 항생제, 항균용 사료 첨가제 등의 용도로 효과적으로 사용될 수 있다.
Description
본 발명은 여시니아(Yersinia)속, 시겔라(Shigella)속 또는 대장균(Escherichia coli)에 속하는 장내 세균에 대해 사멸능을 갖는 신규한 박테리오파지(KFS-YE) 및 이의 용도에 관한 것이다.
여시니아 엔테로콜리티카(Yersinia enterocolitica)는 통성혐기성, 그람음성간균으로 장내세균과에 속하며, 사람과 동물에서 병원성을 나타내는 병원성 세균이다. 우리나라뿐만 아니라 유럽, 캐나다, 일본 등에서 동물과 사람에서 주로 설사를 일으키며, Salmonella와 Campylobacter 다음으로 많이 발생하는 것으로 보고되어 있다(Fredriksson-Ahomaa, M., Stolle, A., & Stephan, R. (2007). Prevalence of pathogenic in pigs slaughtered Yersinia enterocolitica at a Swiss abattoir. International Journal of Food Microbiology, 119, 207-12). 이 균에 감염될 경우 급성위장질환과 패혈증 등과 같은 여시니아증(yersiniosis)이 유발되며, 최근에는 돼지, 소, 닭, 양 등과 같은 동물들이 주로 이 균에 감염되어 권태, 식욕감퇴, 체중감소, 설사, 심한 유연 등을 앓다가 패혈증으로 죽기도 한다. 특히 사육장 내 오염된 토양이나 물, 사료를 통해 쉽게 전염되므로, 가축 시장에 경제적 피해가 우려된다. 또한, 인체에는 주로 덜 익힌 돼지고기 같은 육제품을 통해 감염되며, 돼지, 소, 닭 등의 동물과 유제품, 육류, 난제품, 야채류 등의 식품 및 하수, 토양 등의 환경에서 다양하게 존재한다(Lim, S.Y., et al. (1999). Characteristis of Yersinia enterocolitica isolated from foods. Korean Journal of Food Science and Technology, 31, 183-188). 특히, 이 균은 냉장 온도에서도 생육이 가능하기 때문에, 냉장식품이나 진공처리된 식품에서도 제어가 용이하지 않아 식품산업계에서도 이를 제어하기 위한 기술에 많은 관심을 갖고 있다.
장내세균과에 속하는 그람음성 세균인 시겔라(Shigella)속 세균들은 S. dysenteriae, S. flexneri , S. sonnei , S. doydii의 4종이 알려져 있는데, 세균성 이질을 발생시키며, 감염력이 강하고, 다제내성균이 많이 존재하는 특징이 있다. 시겔라 손네이(Shigella sonnei) 균은 나머지 3종에 비해 상대적으로 약한 균으로 평가되지만, 이 균이 대장을 침범할 경우 고열, 설사, 혈변 등의 증상이 나타나면서 심하면 사망에 이르기도 한다.
대장균(Escherichia coli)은 사람을 포함한 포유류의 장관에 기생하는 장내세균으로, 통성혐기성 그람음성의 간균이며, 글루코오스를 분해하여 산을 생산하는 것으로 알려져 있으며, 동물의 분변에 오염된 물질에 널리 존재하기 때문에 식품의 변질에 의한 오염을 검사하는 지표로 사용된다. 병원성을 나타내는 대장균은 다음 4군의 병원균이 알려져 있다. (1) 병원성 대장균(약칭 EPEC): 유아 설사증의 원인이 되며 특정한 O항원이 있다. (2) 세포침입성 대장균: 살모넬라속균과 같이 장관상피세포 내에 침입하여 세포를 파괴한다. (3) 독소원성 대장균(ETEC): 소아나 성인의 설사증의 원인이 되고, 특히 열대나 아열대지방에서 여행자설사증의 원인균으로 세계적인 주목을 받고 있다. (4) 장관출혈성 대장균(EHEC): 베로톡신(VT)을 생산하며 출혈성 대장염과 용혈성 요독증증후군 등을 일으킨다([네이버 지식백과] 대장균 [colon bacterium, 大腸菌] (생명과학대사전, 초판 2008., 개정판 2014., 도서출판 여초) 참조).
상기 병원성 장내세균에 감염된 경우 치료를 위해 주로 화합물인 항생제가 사용되어 왔으나 날이 갈수록 항생제 내성균의 발생 등에 따른 부작용이 심각해지고 있으며, 이에 따라 상기 균들을 사멸시킬 수 있는 새로운 기술의 개발에 대한 요구가 커지고 있는 실정이다. 그 중 하나가 세균의 성장을 억제하는 세균 특이적인 바이러스인 박테리오파지(bacteriophage)를 이용하는 것이다. 박테리오파지는 세균의 성장을 억제하는 세균 특이적인 바이러스를 의미하며 특정 박테리아에만 특이적으로 작용하는 숙주특이성이 높고, 온도, pH, 유기용매에서 비교적 안정한 장점이 있기 때문에 항생제 대체제 및 병원성 세균을 제어할 수 있는 biocontrol agent 및 bio-recognition agent로서 각광받고 있다.
이에 본 발명자들은 종래 연구가 부족했던 여시니아 엔테로콜리티카의 예방 및 제어를 위한 박테리오파지를 개발하기 위해 닭 가공 공장의 폐수로부터 신규한 박테리오파지를 분리하였으며, 이 박테리오파지의 숙주 범위 및 안정성 등을 실험하던 중 여시니아(Yersinia) 속 균주 뿐만 아니라 시겔라(Shigella)속 세균과 Big-six non-0157 STEC (shiga-toxin producing Escherichia coli)에 속하는 BAA-2196 및 BAA-2192 대장균에 대해서도 성장 저해 및 용균 활성을 나타내는 것을 확인하고 본 발명을 완성하였다.
본 발명의 목적은 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 또는 대장균(Escherichia coli)에 대해 특이적인 증식 억제 또는 사멸능을 갖는 박테리오파지를 제공하는 것이다.
본 발명의 다른 목적은 상기 박테리오파지를 유효성분으로 함유하는 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 또는 대장균(Escherichia coli)에 대한 증식 억제 또는 사멸용 조성물을 제공하는 것이다.
본 발명의 다른 목적은 상기 박테리오파지를 유효성분으로 함유하는 장내세균에 의해 유발되는 질환의 예방 또는 치료용 약학 조성물을 제공하는 것이다.
본 발명의 또다른 목적은 상기 박테리오파지를 함유하는 항생제, 소독제 또는 항균용 사료 첨가제를 제공하는 것이다.
상기 과제를 해결하기 위하여, 본 발명은 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 및 대장균(Escherichia coli)으로 이루어진 장내세균으로부터 선택되는 어느 하나 이상의 균에 대해 특이적인 증식 억제 또는 사멸능을 갖는 신규한 박테리오파지를 제공한다.
본 발명의 일실시예에 있어서, 상기 박테리오파지는 서열번호 1의 염기서열로 구성되는 유전체를 갖는 것이다.
본 발명의 일실시예에 있어서, 상기 박테리오파지는 수탁번호 KCTC 13148BP로 기탁된 박테리오파지이다.
본 발명의 일실시예에 있어서, 상기 여시니아(Yersinia)속 균주는 여시니아 엔테로콜리티카(Yersinia enterocolitica)이고, 상기 시겔라(Shigella)속 균주는 시겔라 손네이(Shigella sonnei)이나, 이에 제한되는 것은 아니다.
다른 양태로서 본 발명은 상기 본 발명의 박테리오파지를 유효성분으로 함유하는, 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 및 대장균(Escherichia coli)으로 이루어진 장내세균으로부터 선택되는 어느 하나 이상의 균에 대한 증식 억제 또는 사멸용 조성물을 제공한다. 본 발명의 일실시예에 있어서, 상기 여시니아(Yersinia)속 균주는 여시니아 엔테로콜리티카(Yersinia enterocolitica)이고, 상기 시겔라(Shigella)속 균주는 시겔라 손네이(Shigella sonnei)이나, 이에 제한되는 것은 아니다.
다른 양태로서 본 발명은 상기 박테리오파지를 유효성분으로 함유하는, 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 및 대장균(Escherichia coli)으로 이루어진 장내세균으로부터 선택되는 어느 하나 이상의 균에 의해 유발되는 질환의 예방 또는 치료용 약학적 조성물을 제공한다.
본 발명의 일실시예에 있어서, 상기 여시니아(Yersinia)속 균주는 여시니아 엔테로콜리티카(Yersinia enterocolitica)이고, 상기 시겔라(Shigella)속 균주는 시겔라 손네이(Shigella sonnei)이나, 이에 제한되는 것은 아니다.
본 발명의 일실시예에 있어서, 상기 질환은 위장염, 관절염, 패혈증, 결핵성 홍반, 균혈증(Bacteremia), 가금티푸스, 장염, 설사, 및 복통 또는 발열을 동반하는 식중독 질환으로 이루어진 군으로부터 선택되는 어느 하나 이상의 질환일 수 있으나, 이에 제한되는 것은 아니다.
다른 양태로서 본 발명은 상기 박테리오파지를 유효성분으로 함유하는 항생제를 제공한다.
다른 양태로서 본 발명은 상기 박테리오파지를 유효성분으로 함유하는 소독제를 제공한다.
다른 양태로서 본 발명은 상기 박테리오파지를 유효성분으로 함유하는 항균용 사료 첨가제를 제공한다.
본 발명의 박테리오파지는 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 및 대장균(Escherichia coli)에 대해 특이적인 증식 억제 또는 사멸능을 나타내므로, 상기 박테리오파지 또는 이의 배양물은 상기 균들에 의해 유발되는 질환의 예방 또는 치료용 약학적 조성물, 항생제, 항균용 사료 첨가제 등의 용도로 효과적으로 사용될 수 있다.
도 1은 여시니아 엔테로콜리티카 ATCC 23715에 대한 본 발명의 박테리오파지(KFS-YE)의 용균 활성을 나타낸 것이다. (좌) 박테리오파지 존재유무 확인을 위한 Dot assay 결과, (우) 박테리오파지 농도 확인을 위한 plaque assay 결과.
도 2는 본 발명의 박테리오파지(KFS-YE)의 전자 현미경 사진이다. 꼬리가 수축되지 않은 박테리오파지(좌)와 수축된 박테리오파지(우)를 비교하였다.
도 3은 본 발명의 박테리오파지(KFS-YE)의 SDS-PAGE 결과를 나타낸 것이다.
도 4는 본 발명의 박테리오파지(KFS-YE)의 내열성 실험 결과를 나타낸 것이다.
도 5는 본 발명의 박테리오파지(KFS-YE)의 내산성 실험 결과를 나타낸 것이다.
도 6은 본 발명의 박테리오파지(KFS-YE) Y. enterocolitica 성장 저해능 실험 결과를 나타낸 것이다.
도 2는 본 발명의 박테리오파지(KFS-YE)의 전자 현미경 사진이다. 꼬리가 수축되지 않은 박테리오파지(좌)와 수축된 박테리오파지(우)를 비교하였다.
도 3은 본 발명의 박테리오파지(KFS-YE)의 SDS-PAGE 결과를 나타낸 것이다.
도 4는 본 발명의 박테리오파지(KFS-YE)의 내열성 실험 결과를 나타낸 것이다.
도 5는 본 발명의 박테리오파지(KFS-YE)의 내산성 실험 결과를 나타낸 것이다.
도 6은 본 발명의 박테리오파지(KFS-YE) Y. enterocolitica 성장 저해능 실험 결과를 나타낸 것이다.
본 발명자들은 여시니아 엔테로콜리티카의 예방 및 제어를 위한 신규 박테리오파지를 개발하기 위해 닭 가공 공장에서 닭 내장 처리공정으로부터 수득한 시료액을 이용하여 용균반 검사를 실시함으로써, 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 및 대장균(Escherichia coli)에 대해 특이적인 사멸능을 나타내는 본 발명의 박테리오파지를 분리하고 이를 "KFS-YE"로 명명하였다. 또한, 유전체 분석을 통해 KFS-YE가 신규한 박테리오파지임을 확인하고 2016년 11월 7일 한국생명공학연구원 생물자원센터에 수탁번호 KCTC13148BP로 기탁하였다.
구체적으로 본 발명의 박테리오파지 KFS-YE은 여시니아 엔테로콜리티카 뿐만 아니라 시겔라 손네이(Shigella sonnei)와 대장균을 선택적으로 감염시키는 종 특이성을 갖고 있으며(표 2), 정이십면체의 머리(isometric capsid)와 꼬리(tail)가 관찰되는 구조를 갖는(도 2), 형태학상 미오비리데(Myoviridae)에 속하는 박테리오파지이며, 36 kDa -170 kDa 범위 안에 41,45 61 kDa 크기의 주요 단백질을 포함한 총 14개의 단백질로 구성되어 있음을 확인하였다(도 3). 또한, 박테리오파지 KFS-YE는 내열성에 있어서 4 - 50 ℃에서 1시간 동안 노출 시 활성을 잃지 않고 유지되었으며(도 4), pH 4.0부터 pH 11.0까지 활성을 잃지 않고 안정적인 내산성을 나타내었으며(도 5), 대상 박테리아의 성장 저해능을 흡광도를 이용하여 확인한 결과, KFS-YE 접종 후 12시간 까지 박테리아의 성장이 저해되는 것으로 확인되었다(도 6).
또한, 본 발명에 따른 KFS-YE는 통상적인 파지 배양법에 의해 대량으로 배양할 수 있다. 배양 배지로는 탄소원, 질소원, 비타민 및 미네랄로 구성된 배지를 사용할 수 있다. 예를 들어, TSB (tryptic soy broth), LB (luria betani broth) 액체 배지, 또는 TSA (tryptic soy agar) 고체배지 등을 사용할 수 있다. 배양은 통상의 배양조건으로 수행할 수 있다. 배양액 중의 배양배지를 제거하고 농축된 균체만을 회수하기 위해 원심분리 또는 여과과정을 거칠 수 있으며 이러한 단계는 당해 기술 분야에서 통상의 지식을 가진 자의 필요에 따라 수행할 수 있다. 농축된 균체는 통상적인 방법에 따라 냉동하거나 냉동 건조하여 그 활성을 잃지 않도록 보존할 수 있다.
따라서, 본 발명은 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 및 대장균(Escherichia coli)으로 이루어진 장내세균으로부터 선택되는 어느 하나 이상의 균에 대해 특이적인 증식 억제 또는 사멸능을 갖는 신규한 박테리오파지를 제공할 수 있다. 본 발명의 일실시예에 있어서, 상기 박테리오파지는 서열번호 1의 염기서열로 구성되는 유전체를 갖는다.
또한, 본 발명은 상기의 박테리오파지를 유효성분으로 함유하는, 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 및 대장균(Escherichia coli)으로 이루어진 장내세균으로부터 선택되는 어느 하나 이상의 균에 의해 유발되는 질환의 예방 또는 치료용 약학적 조성물을 제공한다. 본 발명의 일실시예에 있어서, 상기 질환은 위장염, 관절염, 패혈증, 결핵성 홍반, 균혈증(Bacteremia), 가금티푸스, 장염, 설사, 및 복통 또는 발열을 동반하는 식중독 질환으로 이루어진 군으로부터 선택되는 어느 하나 이상의 질환일 수 있으나, 이에 제한되는 것은 아니다.
상기 본 발명의 약학적 조성물은 생물학적 제제에 통상적으로 사용되는 담체, 희석제, 부형제 또는 둘 이상의 이들의 조합을 포함할 수 있다. 약제학적으로 허용 가능한 담체는 조성물을 생체 내 전달에 적합한 것이면 특별히 제한되지 않으며, 예를 들어 식염수, 멸균수, 링거액, 완충 식염수, 덱스트로스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 등을 혼합하여 이용할 수 있으며, 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한, 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주이용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다. 또한, 본 발명의 조성물은 추가로 동일 또는 유사한 기능을 나타내는 유효성분을 1종 이상 함유할 수 있다.
본 발명의 조성물은 목적하는 방법에 따라 비 경구 투여(예를 들어 정맥 내, 피하, 복강 내 또는 국소에 적용)하거나 경구 투여할 수 있다. 본 발명의 약학적 조성물의 적합한 투여량은 환자의 체중, 연령, 성별, 건강상태, 식이, 제제화 방법, 투여시간, 투여방법, 배설률 및 질환의 중증도 등에 따라 결정될 수 있다.
또한, 상기 본 발명의 박테리오파지는 세균 증식 억제 또는 사멸용 미생물제제, 항생제 및 소독제로 사용할 수 있다. 본 발명의 세균 증식 억제 또는 사멸용 조성물, 미생물제제, 항생제 및 소독제는 통상적인 세균 증식 억제 또는 사멸용 조성물, 항생제 및 소독제 제조방법으로 제조될 수 있으며, 유효성분인 본 발명의 박테리오파지 또는 이의 배양물 이외에 담체, 기타 보조제 등을 추가적으로 포함할 수 있다. 상기 담체는 생리식염수, 증류수, 세균 배양용 배지 등일 수 있으며, 보조제는 버퍼 등일 수 있으나 이에 한정되는 것은 아니다.
또한, 본 발명은 상기 박테리오파지 또는 이의 배양물을 유효성분으로 함유하는 항균용 사료 첨가제 또는 식품 첨가제를 제공한다. 상기 박테리오파지 또는 이의 배양물은 상기 기재한 바와 같이 여시니아 속 균주, 시겔라 속 균주 또는 대장균에 대해 특이적 사멸능을 나타내므로, 상기 성분을 유효성분으로 함유하는 본 발명의 사료첨가제 또는 식품첨가제는 상기 균주를 특이적으로 사멸시킬 수 있다. 본 발명의 일실시예에 있어서, 상기 여시니아 속 균은 여시니아 엔테로콜리티가이며, 상기 시겔라 속 균은 시겔라 소네이 균인 것이 바람직하나, 이에 제한되는 것은 아니다. 상기 사료첨가제는 가축용 및 어류용 사료에 첨가제의 형태로 제조될 수 있으며, 병원균의 감염 용이성, 감염 정도 등에 따라 첨가량을 달리 정할 수 있다. 상기 식품 첨가제가 사용될 수 있는 식품에는 제한이 없으며, 상기 첨가제는 상기 균에 감염되기 쉬운 식품에 당업계에 공지된 방법에 따라 첨가제의 형태로 제조될 수 있다.
이하 본 발명을 실시예에 의하여 더욱 상세하게 설명한다. 이들 실시예는 단지 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본 발명의 범위가 이들 실시예에 국한되지 않는다는 것은 당업계에서 통상의 지식을 가진 자에게 있어서 자명할 것이다.
<실시예 1>
박테리오파지의 분리
<1-1> 대상 박테리아 및 파지의 샘플링
경상북도 상주시에 소재하는 닭 공장에서 닭 내장 처리공정으로부터 수득한 시료 25 ml을 이용하여 시료액을 준비하고, 이를 이용하여 소프트 아가 오버레이 (soft agar overlay) 방법을 수행하였다. 상기 소프트 아가 오버레이 방법이란 탑-아가(top-agar, 0.4% 한천을 이용하여 고체 배지 위에 붙이는 것)에서 성장하는 숙주세포를 이용하여 박테리오파지가 용균하는 것을 관찰하는 방법을 말한다.
구체적으로, TSB배지 225 ml에 샘플 25 ml와 여시니아 엔테로콜리티카 (Yersinia enterocolitica ATCC 23715) 진탕 배양액 (OD640 = 0.3) 1%을 혼합하고 이를 37 ℃에서 18시간 동안 배양한 다음, 상기 배양액을 8,000 rpm에서 10분간 원심 분리하여 그 상등액을 0.25 um 필터로 여과하였다. 그 다음, TSA 평판 배지의 위에 TA soft agar (0.4%(w/v) agar, nutrient broth, NaCl, MgSO4, CaCl2) 4 ml와 여시니아 엔테로콜리티카 ATCC 23715 진탕 배양액 (OD600 = 0.465) 200 ul의 혼합액을 부어 굳힌 후, 그 위에 상기 시료액 10 ul를 적가하고 37 ℃에서 18시간 동안 배양하여 용균반이 형성됨을 확인하였다(도 1).
하나의 용균반에는 한 종류의 박테리오파지가 존재한다고 알려져 있기 때문에, 상기 형성된 용균반으로부터 단일 박테리오파지를 분리하고자 하였다. 구체적으로, 상기 용균반을 900 ul의 SM 용액 (50 mM Tris-HCl, 100mM NaCl, 10mM MgSO4)에 가하고 실온에서 2시간 동안 방치하여 박테리오파지 용액을 수득하였다.
<1-2> 박테리오파지의 대량 배양 및 정제
상기 실시예 1-1에서 수득한 박테리오파지를 여시니아 엔테로콜리티카 ATCC 23715를 이용하여 대량으로 배양하고 이로부터 박테리오파지를 정제하였다.
구체적으로, 여시니아 엔테로콜리티카 ATCC 23715를 진탕배양하여 TA broth (nutrient broth, NaCl, MgSO4, CaCl2) 3 ml에 분주한 후, 2시간 배양시킨 후, 실시예 1-1에서 수득한 박테리오파지를 분주하여 마찬가지로 2시간 배양시킨 후, 원심분리하여 필터링하여 박테리오파지만을 분리하였다. 동일한 방법으로 TA broth의 양을 조절하여 3, 8, 20, 200, 800 ml순으로 진행한다. 그 다음 최종 농도가 10%(w/v)가 되도록 폴리에틸렌글리콜(polyethylene glycol, PEG)과 1M NaCl을 가하여 4 ℃에서 16시간 동안 추가 정치시켰으며, 4 ℃에서 8,000 rpm으로 20분간 원심 분리하여 침전물을 수득하였다.
정제된 파지는 CsCl 밀도 구배 울트라원심분리 (밀도 구배: 1.20, 1.30, 1.40, 1.45, 1.50, 1.70g/ml; 22,000rpm; 2h; 4 ℃) 후, SM 용액 (50 mM Tris-HCl, 100mM NaCl, 10mM MgSO4)에서 투석 과정을 거친 후 4 ℃에 보관하였다.
위와 같이 분리된 박테리오파지를 "KFS-YE"로 명명하고, 2016년 11월 7일 한국생명공학연구원에 수탁번호 KCTC13148BP로 기탁하였다.
<
실시예
2>
본 발명의 박테리오파지
KFS
-YE의 동정
<2-1> 박테리오파지
KFS
-YE의 형태학적 분석
분리된 본 발명의 박테리오파지 KFS-YE의 형태학적 분석을 위해 투과전자현미경(TEM) 관찰을 수행하였다. 분리된 파지를 구리 그리드(grid)에 로드(load)한 후에, 2% 포스포텅스텐산(phosphotungstic acid)으로 음성 염색(negative stain)하고 건조하였다. 전자현미경 촬영은 경북대학교 공동실험실습관에서 보유하고 있는 H-7100(Hitachi)를 이용하여 100 kV의 전압으로 관찰을 진행하였다.
관찰 결과, 박테리오파지 KFS-YE는 머리(가로: 102.4 ± 6.1 nm, 세로: 118.4 ± 11.6 nm)와 꼬리(비수축 : 125.7 ± 15.8 nm, 수축 : 48.2 ± 4.6 nm)로 구성되어 있었으며, 수축성 꼬리를 갖는 것으로 보아 미오비리대(Myoviridae)에 속한다는 것을 알 수 있었다(도 2).
<2-2>
KFS
-YE의 구조 단백질 패턴 분석
1.53 × 1011 PFU/ml 농도의 정제된 박테리오파지 KFS-YE 용액 40 ㎕와 5X SDS 시료 용액 10 ㎕를 혼합하여 95 ℃에서 5분간 끓인 다음, 10% SDS-PAGE를 수행하였다.
그 결과, 박테리오파지 KFS-YE를 대상으로 수행한 SDS-PAGE 결과를 나타내는 전기영동 사진(도 3)에서 확인할 수 있는 바와 같이, 36kDa에서 170kDa의 범위에서 총 14개의 단백질밴드를 확인할 수 있었고, 약 40 kDa, 45 kDa 및 61 kDa 크기의 세 개의 주요 단백질을 가지는 것을 확인할 수 있었다.
<2-3>
KFS
-YE의 유전학적 분석
본 발명의 박테리오파지 KFS-YE의 유전체를 분석하기 위해 Phage DNA Isolation Kit (NORGEN, Canada)를 사용하여 gDNA를 순수 분리하였다. 분리된 gDNA에 대해 전체 유전자 염기서열을 결정하기 위하여 Labgenomics에 의뢰하여 서열을 분석하였다. 전체 염기서열 분석은 Genome Sequencer Illumina SBS chemistry sequencer와 de novo assembler software (Platanus 1.24)을 통하여 수행하였고, 분석된 전체 염기서열을 서열번호 1에 기재하였다.
유전체 분석 결과, 박테리오파지의 유전체는 이중가닥 DNA로 그 크기가 168 kbp이고, 267 개의 open reading frames (ORF)로 구성되어 있으며, 번역 된 BLAST는 파지의 번역 된 게놈 서열을 정렬하는 데 사용되었다. 이 전체 염기서열을 미국 NCBI의 BLAST 검색한 결과, Yersinia pseudotuberculosis에 특이적인 파지인 미오비리데(Myoviridae)과의 yersinia phage PST와 염기서열이 유사하였고, 34개의 ORF는 Yersinia phage PST와 관련하여 대칭 유전자 서열을 갖는 것으로 발견되었다. 따라서 기존 여시니아에 특이적인 박테리오파지와 동일하지 않은 신규한 것임을 알 수 있었다. 또한 기존에 연구된 여시니아에 특이적인 박테리오파지와 비교분석한 결과 아래 표 1에서와 같이 많은 차이가 있음을 확인할 수 있었다.
<실시예 3>
본 발명의 박테리오파지
KFS
-YE의 안정성
<3-1> 온도에 따른
KFS
-YE의 안정성 조사
박테리오파지 KFS-YE의 열에 대한 안정성을 확인하기 위해 다양한 온도에 박테리오파지 KFS-YE를 노출시켜 안정성을 실험하였다.
구체적으로, 1.53 X 108 PFU/ml 농도의 KFS-YE 용액 1 ml를 각각의 온도(4, 22, 37, 50, 60, 70 및 80 ℃)에서 1시간 동안 정치시킨 다음, 소프트 아가 오버레이 방법으로 역가를 측정하였다.
그 결과, 박테리오파지 KFS-YE는 4 - 50 ℃의 온도범위에서 활성을 유지하는 것으로 확인되었다(도 4).
<3-2> pH에 따른
KFS
-YE의 안정성 조사
박테리오파지 KFS-YE의 pH 안정성을 확인하기 위하여 다양한 pH(pH 3, 4, 5, 7, 9 및 11)에 대한 안정성 조사 실험을 실시하였다.
구체적으로, 상기 각 pH 용액 900 ul와 1.53 X 108 PFU/ml 농도의 KFS-YE 100 ㎕를 혼합하여 1시간 동안 상온에서 정치시킨 후 소프트 아가 오버레이 방법을 이용하여 박테리오파지의 역가를 측정하였다.
그 결과, 박테리오파지 KFS-YE는 pH 4 부터 pH 11까지 유의차가 없는 것으로 나타났다. 따라서 박테리오파지 KFS-YE의 경우 넓은 범위의 pH에서 활성을 유지하는 것으로 확인되었다(도 5).
<
실시예
4>
본 발명의 박테리오파지
KFS
-YE의 용균 활성
상기 실시예 1에서 정제한 박테리오파지 KFS-YE가 여시니아 엔테로콜리티카 이외에 다른 병원성 균주에 대하여도 용균 활성을 나타내는지 여부를 확인하기 위해 숙주 범위 측정 실험을 수행하였다.
구체적으로, 여시니아 엔테로콜리티카 2종 외 병원성 세균 28종을 각각 배양하여 각각의 배양액에 대해 상기 정제한 본 발명의 박테리오파지 KFS-YE의 용균반 형성여부를 상기 소프트 아가 오버레이 방법을 수행하여 확인하고 그 결과를 표 2에 나타내었다.
| 균주 명칭 (수탁번호) | 용균반 형성 여부 |
| Yersinia enterocolitica (ATCC 23715) | ++ |
| Yersinia enterocolitica (ATCC 55075) | + |
| Aeromonas hydrophila ( ATCC 7966) | - |
| Aeromonas hydrophila JUNAH | - |
| Aeromonas hydrophila SNUFPC A3 | - |
| Aeromonas hydrophila SNUFPC A5 | - |
| Aeromonas hydrophila SNUFPC A6 | - |
| Aeromonas hydrophila SNUFPC A7 | - |
| Aeromonas hydrophila SNUFPC A8 | - |
| Aeromonas hydrophila SNUFPC A9 | - |
| Aeromonas hydrophila SNUFPC A10 | - |
| Aeromonas hydrophila SNUFPC A11 | - |
| Bacillus cereus ( ATCC 13061) | - |
| Bacillus cereus ( ATCC 21768) | - |
| Bacillus subtilis ( ATCC 6633) | - |
| Escherichia coli ( ATCC BAA-2192) | + |
| Escherichia coli ( ATCC BAA-2196) | ++ |
| Klebsiella pneumoniae ( ATCC 13883) | - |
| Listeria monocytogenes ( ATCC 19116) | - |
| Listeria monocytogenes ( ATCC 7644) | - |
| Listeria innocua ( ATCC 33090) | - |
| Pseudomonas aeruginosa (ATCC 10145) | - |
| Pseudomonas aeruginosa (ATCC 9027) | - |
| Salmonella Enteritidis ( ATCC 13076) | - |
| Salmonella Typhimurium ( ATCC 19586) | - |
| Salmonella Typhimurium ( ATCC 15812) | - |
| Staphylococcus aureus ( ATCC 25923) | - |
| Shigella sonnei ( ATCC 9290) | + |
| Vibrio parahaemolyticus ( ATCC 43996) | - |
| Vibrio parahaemolyticus ( ATCC 17802) | - |
++ : 투명한 플라크, + : 탁한 플라크, - : 플라크 형성 무
상기 표 2에서 확인할 수 있는 바와 같이, 본 발명의 박테리오파지 KFS-YE는 여시니아 엔테로콜리티카 뿐만 아니라 시겔라 손네이(Shigella sonnei)와 대장균에 대해서도 특이적인 용균 활성을 나타내었다.
<
실시예
5>
본 발명의 박테리오파지
KFS
-YE의 성장
저해능
박테리오파지 KFS-YE를 식품에 적용하기에 앞서 액체배지에서 Y. enterocolitica 의 성장 억제 저해능을 확인하기 위해 액체배지에 Y. enterocolitica를 성장시킨 후, MOI(multiplicity of infection) 1의 비율로 KFS-YE를 접종하여 24시간 동안 흡광도를 관찰하여 Y. enterocolitica의 성장 저해능을 확인하였다.
구체적으로, 100 mL의 TSB 배지에 하룻밤 배양시킨 Y. enterocolitica를 접종한다. OD640 값이 0.3 (약 108 CFU/ml)이 되었을 때, 108 PFU/ml의 KFS-YE 용액 1 ml을 접종하고 24시간 동안 3시간마다 흡광도값을 측정하였다.,
그 결과, 도 6에서 확인할 수 있는 바와 같이, KFS-YE를 접종하지 않은 컨트롤의 경우(control), 배양 3시간 만에 OD640 값 1을 넘어 1010 CFU/ml의 농도로 여시니아균이 지속적으로 성장하는 반면, KFS-YE 접종한 경우(MOI=1)에는, KFS-YE 접종 후 3시간 만에 OD640 값 0.02로 떨어져 12시간까지 유지되었다. 따라서, KFS-YE가 Y. enterocolitica의 성장을 억제함을 확인할 수 있었다.
이제까지 본 발명에 대하여 그 바람직한 실시예들을 중심으로 살펴보았다. 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자는 본 발명이 본 발명의 본질적인 특성에서 벗어나지 않는 범위에서 변형된 형태로 구현될 수 있음을 이해할 수 있을 것이다. 그러므로 개시된 실시예들은 한정적인 관점이 아니라 설명적인 관점에서 고려되어야 한다. 본 발명의 범위는 전술한 설명이 아니라 특허청구범위에 나타나 있으며, 그와 동등한 범위 내에 있는 모든 차이점은 본 발명에 포함된 것으로 해석되어야 할 것이다.
SEQUENCE LISTING
<110> Industry-Academic Cooperation Foundation of Kyungpook
National University
<120> Novel bacteriophage having bacteriocidal activity against
pathogenic enterobacteria and uses thereof
<130> PN1705-170
<160> 1
<170> PatentIn version 3.2
<210> 1
<211> 168394
<212> DNA
<213> KFS-YE
<400> 1
ccttgaccac gaacattaca tctacctcct gcggagccaa catcaccacc gccaccaccg 60
ttatagacac cattcacgga tcctgagcca ggtgcagaaa tagtaccgcc agtcgcgcct 120
gattgcatat tagcagaccc accagcagca ccaaaaggac gaccgcctcc accgccaaaa 180
gtcaatctca tttgtagaaa aggagccaat aatccgccgc caccgccgcc accgccgcct 240
gcaatagctc caccattatt aattcttagt ctcccaccaa tatcgttttg aatacaatgg 300
cccccagctg aaccaggact attgctaccg ccattaccgc cacggccata catcgttaca 360
ccgtgtatat tcagttgaac atattcattc ggtgtatctc cgtacatgaa gaataaagga 420
acatctttag aatatgatac taaatctcca gtgatattaa acactatagg tgcactacct 480
gcctcaaaac atctatctcg gaaccattgg ccattgaagt tatggtctgc tccaagcgtg 540
tgaattattt caacagatcg acctatcata ttactcatcc agaacggaat gcccattctt 600
aatcgttggg ccgcgccacc catccaattt tgtcctgtat taactactgc agacgatcct 660
acccacggtc ctgttactgc catataaacc tccaaggggc cgaagcccct cttattattt 720
taacaatgat ttaactaatg ctttaagttc ttcaatttct gatttaagtt ccgcaatttc 780
tgcagtatgc tcattgattg cagctgtatt taaaccaatt acaccgttat agttcaaacg 840
aagtaaagct tcgccatcag ggtcaccttc aactaattca ggcaaaatag cttgaacttc 900
ctgagctatc aaaccggcgt taggttccca tttctgattg ccttcttcat ctaggcctcg 960
cttctgcata taagtgtaac cgttaatttt agaaagcttc tgagaagcat tttcaaattt 1020
aacaaggtct tttttaacac gaatatcaga acggacataa acatcgcgga caaatgtgga 1080
ataggcatcg ctttgttgga ctaaatgacc aaaagaaata atagctcttc cttgttcagt 1140
ccacagagca ccagtggtat cccaaagacc ttcatggaga tggtaagcgg acgaccatga 1200
agcaatatgc actccatttg caaccatgtt aatacgaccg tcaccgccat gaactaatcc 1260
agtatcatta tcaccaataa caagacacgg gccggtccat acagggtcac caccgccagc 1320
tgataatctt gctccagctt gaaccatatt aggagcatac agaactccat tgtggtgaaa 1380
ttcatagata gcttgtgggt cagaaccatt ttcctggtta ccaacacgga taatagcctg 1440
agcccattgg ttagtagtgc gtcgcatacc aaaatcaaca cccgatatgt atccttcatt 1500
agtaatacta gattttcctt tgataatcgg gtaataacta tcattaccga cattgccaaa 1560
atctacaaat atcggcgctt cttgtcgcca ttggtttccc caatcaccag cttggtgcgc 1620
aacccattgt gtaccgttta tatgaaggcg gtctctatta aaattaaatg ttccttgacc 1680
ttgaggagaa agcgatattt cgccgttatt tgttatgtat acaccgcctt gtgtaatgta 1740
actataaaaa cctagaccat tgtcgccgcc gcctttacca atataccaat tattggcccc 1800
ggccgtatca gaacgaataa atgatgaatc actggtcaaa ggaggattaa gaactattcc 1860
agcagcatct ttattaatcc aaagagtgcc ggtcatcgtg tcgccttctt tagacacacg 1920
ggaggcaata gcatcgtgaa tgttagttat atcaccagct gaagtaaatg ttttccaaat 1980
atcagaccag atgttaccat tgcgagcaat agtagcttca ccgccaccga cttgaacgtt 2040
atccgggaag ttaacagtac cgtcttgatt aaaacgagac gtatggcctt gtgaaccatc 2100
ttctttcaga tgatgaataa cgaatgtacc cgaattaatt tcagtaccta aagaccaaac 2160
tgctttaccg tttaaaaact tctgcttaac aataggataa tatttactta cagcatcatc 2220
atcgatttcc tggaaaatag gagccgcttg aacatattga atgtcataac caccagcgcc 2280
agcgccatga ccaacaaatt taatatagcc gttcgcagcg aacgtattgt aacttgattg 2340
taaatctgga atagtaactt taccggtatc taaagccata ctaaacgggc gaagtggacc 2400
gatatcgcca tgtttacctt caccataagc agttggaata atatgaagac tgccttctga 2460
acgtctaaaa atagctccat aatctgcgtt ccaaatgcga agaccattta cagcatttgt 2520
cgcgatttca ccggctgcgc tgattgtacc gtcaaatgta gcatttttta ctactgtaaa 2580
gttttcatta acaatctggg tgccatttat aaccgattcg attttacccg cagttgttcg 2640
ttgaatataa tgcatccatc caatatcatc agaaatttcc atgacatttt tacgggtgcc 2700
ttcacttgga ttagtaaaag tatttcccca aacagctata tacatgttat caacggagct 2760
ttgacccatg gtatagcatt taaacattaa agttgaatta ttatttctac catcaatatt 2820
aaccgaacca ccaataacgt caatattgcc tggagtaact aacaaaccgc catgagtatt 2880
aatgtttgtg gtacccttac cgcggaaata gtgatgatag ttaccgcctt gataatatcc 2940
taaaagagtt tgaccgtcac catacgcgtt attatcatgg taagtaacaa cagtggctaa 3000
tgcatagttt tctgtcggtg gcgttgtcat aagaatccca tccggagaat aacccataac 3060
catttttcta aggctttgtg tttccgcagg accgtaaatg aaagttcttg ttccgttgtt 3120
tactgcatga aaatatccgt cctgatgcca tttaaatccg gtatcattat cgccaatagc 3180
aatagaacct ttacctaagg ctgaatatgt cataggactt gattccatac ctactgcaat 3240
tgaatggcct gcttgaagcc caccggaata agaaaatgac aacatgtaat cagtaggggt 3300
tgaaccagaa taccaactga tgccgttatt ttcacaaatt tcatggagca ttgcggccgc 3360
tgggtcggta cgtacaatgc gcaaatagtt tttatctgtg tcagaattat tatttgctaa 3420
tgaagatata tcataatcgc ccgtcttctt cccatctgta ataactttat cggtcagaat 3480
ttgtggagac gaaatagatt tccatgctga tacttcaggt gaagtaaata ggccactgcc 3540
tgaaaatgca taggtgcttt catcaccagc ggcgtagtct tgaaccctga tattaagtac 3600
ttgtgtagtt aatccatcat tagccggggc ataaattatt ccgcgttcgc ggttattgcc 3660
atcgaaaaaa cgaacatgcg ctgtacttga actttttgta ataagttctc cgccctcagt 3720
cataatctgc ccggcggcaa taatatcgcg agttactcga gcaataccag ttaaattaaa 3780
attacctgtc tgagtgaaag cgccatttaa agtataatca ccagtttgat tatagtttcc 3840
tatatgaata acattcccgt caatgctacc gcccttagca aaaccaagat caatgatatt 3900
tccttggtcg tctttagtaa aaagtacgcg gtcttttaag tttatagcca attcaccttc 3960
ggctaatact gaagcggcag gacgtgctcc tgcagttttg cttcttttaa attgtatttg 4020
ttttaaagta gccataagtc ctcttaataa tagccgaaat cttgaacaga atccttaata 4080
acaatttgat caaatcgtgg aacatgtgaa ggttgagatg caggattctg cgaaaaaagg 4140
tttggcgcag ttaaatttcc tgtcatagta tctccagagc gtaataccct agagtttgcg 4200
tttgctgtaa caatatttat tgctccatca acataatctt tccgtgtaag gtcataatta 4260
tttactggag ataatgaagt tgcgcgtatt tgtgatgctt caattacacc ctttgagcta 4320
atatctccat ttcgcgtgtt aattactaca gttctacccg ctgaaccctg tgatgattta 4380
aaaccaatac cataccacga aacaatatcc atatttgtag tatcatatgt ggcattatca 4440
ccaggaccag caaaaatacc gttgtcacct gaccctgcac caggaacagt cattccttta 4500
ttaaaaatta ctttatttaa atacgtacca ccgttagctt tagaaacgaa atcgttatca 4560
gcagcttgtg gcttattata ttctgaatat attttaaatg atttatagag tacatcgtca 4620
ccggctggat tcaatggaaa atttccttga tgccaaatga cagagcctcc agttgttgaa 4680
cctactttta aatcagccat tgtatgcccc tttattttaa tagtatttat aaagaaaaag 4740
ggaacccgaa ggctccctca atttatactt ctctaaattc ttgcccaaat actttaccag 4800
ctttagacga tgcttgcgta ggaagtacca ttatatccgg aggtgaagca gattcacaga 4860
tataattaac acgaatgccg ttgataccaa attcagcagg tttcgaaata cttccatttc 4920
ttgacacttc cgaaaagctt aaattcctca tgccaccttg accagcttga gcagttcttt 4980
gtgcatatat cgtaaatcct actgcatttt ctggaataac tacataatct tcctttaatt 5040
cccatgaccc agcttgtcca gtaaactcag catgtgttga agaaatatat ccatttgatg 5100
catcataaaa acgaatggat atatttgtag ttccaagatc aagtaaatca gcatcagcat 5160
ataactgtgc tttaagataa agaacatcac caggaattaa attataatca gatagtttac 5220
ttatagcagc tgaagttggt aatcgcgcaa tttcgttatt agttccacca actgctgaca 5280
taaattgctc gacactttca tatgttcttt taggaaatcc tgtagctccg acgtcttcta 5340
aactatcaaa tacaacatct aaaatagttt gatagtcatc tgtgcttttt ctattactta 5400
gtttaacatg ttccaatgca atagctcttt tagaagaagt ataaaaggca gcatatgata 5460
cgtcaaatct tgacaatact gaatctgatg gaaaaactga agttcctgct ccccttaacc 5520
aagatatcac ttcaggagga aaattaacct ttccgctagt tagtatagca acaagtctat 5580
tgtttgacaa agaattcatg aaactaacaa aagcagctga tgtagtatta tttgaagtag 5640
aaaaagcata tgacttacta tcaactaatg ctcctgttga agggtcaaaa actcttaaat 5700
gaagacctgc gctaaatgtt tgatttccga cagggttatc ctgaaattta acatatggtc 5760
ctgctgtaga aagcgggcaa gaacccgcta tacttatttt atatcttact gaattgcttt 5820
ccgataaaaa tggcgtttgg acatatcctt gtccaaactc tgccataaat ttttccataa 5880
tacctcttat tcaacccatt caaatttaac cgttttattc actgggtcag gaataatgcg 5940
aacattacca attcgtaaga aatcacgaat agtaagattc cccattatag cattatcaga 6000
tggtaaagca ccgatatcag atggctgagg agggttacct ccatcaaata cctgaacaaa 6060
gcttgaccaa gaatttttgg ttttctgcca tgtacgcgtc cagcgagtgg tgcgcgcttc 6120
tggggtcgtt ggataagtaa tccaatcttg gtaaagcgaa tcgagtgtgt taccaaattg 6180
agtcagcgta ccaggagatt taacctcttc accgcgttct aagtatggaa gcccagtcac 6240
ttcattagtt ttttcaacca ttttaaaata acccgggaac tggttataag tggctgaatc 6300
attaatatcg attgaccaga atcctacagt atcagatgtt ggcgcacggg tatataaatc 6360
agaggtttta gtaccctgag aacgaattct cgagttaaca gttaaaccac ctgaagttat 6420
agtagcacct ttggcaatga ttaagctttc accaattgta acctgaccag attgattatt 6480
aattgataat ggacgtaatc cattaaaccc accagtctga tcaccagatg cagtaagcat 6540
aaaataggtg ttagcaccat cattacgaat aaagaatccg taatcaccat ttattgctct 6600
aaaagcattc gacgatttac tgataaattc gccattagca gtaactgaac taccgaatgt 6660
tgcaacgcca ttcgcattca atgttcctga agcattcaca tttatcggtg ttactgtacc 6720
attgatatta aatgttatat taccagcttt attgcgctga gaataaaagt gactagacgt 6780
ttcatcacta acttcaaata cagtagaacg cgttgtgtct gattcaccac taaattgatt 6840
tccccacact ttgactgtca tcgtttgagc cgggttcgtt ccagtttgag gtcctttctc 6900
aaaaatcaga cgagttgctg ttccagtatt agaaatggtt agtgtactat ttgctgaaac 6960
tgatccaccg aacgtagcag tactagatga tacaagaggg gcactcagat tcgtttgttg 7020
ggttaaggtt agtgaaccat taaccgtttg tgcaatatcc ctacgaatga actgagatga 7080
atctagacca tccagtaaat tactatctac agcttttgct tttaacggca aataatttgc 7140
taatacacgg tttaattcgt atggcgatac tgcataacta tttttctcgt acaattctaa 7200
tgactgtgtt gaaccaactg tatcattacc aacgaatgta attgaaccag atgaagtttt 7260
aacaaaacct cttaccagag tagtagctgc ccaagtaggt tcactctgca caatccattt 7320
taaatttttt ggagatacag cagtatttgc tgacgttcca gttacagttt cagactgagt 7380
tgcaacttta ataacgcctt cctgcgcttc agtagattta gtacctaaaa gctttttagg 7440
agttattaga acattatcta atgttcctgc agcagcttca acttgcgtag ctacacgaag 7500
tgtaccacgt tgtgtctcat ttgcttcaag aatattaagg gtataatggt cccagagagt 7560
tcctgattca actaatccag atagagcaac aacagaagta cgatcagtac tgttaaatct 7620
ggttttaatt tttaatggtg tagagatacg agtatcgtcg acgcctgcgt cgaattcaac 7680
ttgcgtagca atttcagcta taccacttaa actttcagtt gctttacggt catttaaagt 7740
tttaggagtg actgcacggg tataatcagt tcctgtatta acttcatttt gtgtagcaat 7800
ttcaattaaa ccaattcttg catcagttga tgtcttttta tgtaacgttt ctggcgttac 7860
aaccgcattt gcccatcctt cttggctttg tccagcaatt acttcacttt caactgctaa 7920
aattactgca ccttgttgtg ttggagtagc tttatactga tccaaagctt taggcgaaac 7980
aactaaatta ttagtgtttt tattataaac atttgtacca tttaattcac gactagaagc 8040
tggagtagct cctgcagtag atacaaaagt tacaatacca gataatgatt cagaaccttg 8100
acgagcttga agctttttag gagtaatgat tgtagtatca tcagtacctg tattagtttc 8160
ctgctgcgta gcaatttcag caacgcctct acgagtttct gtagcagttc tttcattcag 8220
ctttttagga gtgatgataa tatcatcagc aaaagagaat gtagtatcct ggttcacttg 8280
ggaagtagtt gctattcttg cgatacctct acgagtttct gtagcagtac ggttagctaa 8340
tgtttctgga gtaattgcta attctttttg cggagaattt tctaaatcag catttgcttg 8400
agcttgtgta gctaaagcaa ttacgcctaa tcttgctcta gtagaatcat ttaaagaatc 8460
aactctttca actgttggca cgttttgctg caccacccag tattttccat cagaatcttc 8520
tatataagca agctgtaaaa ctggaacata attggtttcg ccgttaaaaa ctaattcttg 8580
aacagtcacc cattcagctt caggtggata ttctgaacgt tttgggaatt gcagcaattg 8640
aactgaagaa gcaattttat cttcaccagc agctttgatt ttaactgttt gtccttttct 8700
catataattc atggaaattt taacagtatc accaatggaa atatcggttg gaagctgaag 8760
ttcaattgtt tgggttgttc cgttattcgc tccaaatacc ataacttctt catttggacg 8820
aatactagaa ttagttgtta taatacgtaa acgtgcttta ctatccccgt caaacaatct 8880
ccacaatttt tcattatcat catacatcaa gaaaccatca atcgatgtac ggccttcaat 8940
ggaatgagtt ccaacttctt gcactgaagt tgtttcatcg tatgtagtaa caattgtatg 9000
ataaagtgga tttaatttgt ctaaatcgac gaaattaata atatcgccat gattagcaaa 9060
tctcggaagt ttaatattaa tcgccgcggc tgaagtaaat ctgcgcacga taaaatcgtt 9120
agattgcgcc tgataaagac tcgctggcgt tacaactgcc gcttctctgc tataatcagc 9180
aacatacatt tgccacagac gattactaaa aattaaaact atctgtgatt ttggatgagt 9240
cattagtact gagcgtactt gttgacctct aaagtttaca atgctttgta ccggagctgt 9300
aattaaaacc tggttaactc caggttttcc tccaatatct tggagaacga tagtatcacc 9360
atcaattgga gaagatggca aagtaaatgt aatgtcatta cccgctgcag tgttaactga 9420
aatcgattcg cctgatttta attgataagg tcctgacgaa acagttgtcc agtttgcatc 9480
agtacgtaac gctctccatc gtacgctatt aaaagctcct gctggttttg gaatatcatt 9540
tatagcagcc caaaagcggt tatcataaat gattacaaaa tcttttaaat atccacgagt 9600
tggatcatat tgttgaactg tgttttcttg aattaagtaa tcaacgttaa caccgtcagt 9660
tcctacggta cgatcagcta aagctacgtt gattatttta tcgccacctg cgtccagacc 9720
gtcttctgct ctgaactttc ttttaatctc ggccattctc ccgggctcct attgtgtttt 9780
caataataag tatttatact tgtttacttt aagatttgga tggtatataa tagaaatctc 9840
actaattgaa cgaggttcat atggatttag aaatgatgct ggatgaagat tacaaagaag 9900
gaatttgctt tattgacttt agtcaaattg cgctttcaac tgctttagta aacttcccag 9960
ataaagaaaa aattaattta tcaatggttc gtcatttgat attgaactca attaagttta 10020
atgtcaaaaa agcaaaaact cttggataca ctaaaattgt actgtgtatt gataatgcga 10080
aatctggata ctggcgtcgt gatttcgctt attattataa gaaaaaccgt ggaaaagcac 10140
gagaagaatc gacttgggac tgggaaggtt attttgaatc cagccataaa gttatagatg 10200
aattgaaagc ttatatgcca tacattgtta tggatattga taagtatgaa gcagatgacc 10260
acattgctgt tcttgttaaa aagttctctt tagaaggaca taagatttta atcatttcgt 10320
cggatggtga ctttactcaa cttcacaagt atccaaatgt taagcaatgg tcaccgatgc 10380
ataagaaatg ggttaaaatt aaaagcggtt ctgctgaaat tgactgtatg actaaaattc 10440
ttaagggtga taaaaaggat aacgttgctt cagttaaagt acgatctgac ttttggttta 10500
ccagagttga aggtgaacga actccttcaa tgaaaacatc tattgttgaa gctattgcta 10560
atgaccgtga gcaagctaag gtgcttctca ccgaatctga atataatcga tacaaagaaa 10620
atttagttct aattgatttt gattatattc ctgataatat tgcttcaaac attgtgaatt 10680
actataattc atataaatta ccaccgcgtg gcaaaattta ttcatatttt gtaaaagcgg 10740
gtctttctaa attaactaat agcattaatg aattttgagg tgaataatgg ctaaaaaaga 10800
aatggttgaa tttgatgaag ctatccatgg cgaagacctg gctaaattta tcaaagaagc 10860
atctgatcat aaactgaaaa tttctggtta taatgaattg attaaagata ttcgaattcg 10920
cgccaaagat gaacttggtg ttgatggtaa gatgtttaat cgtcttttag ctttgtatca 10980
taaagataac cgtgatgtgt ttgaagctga aaccgaagag gtagttgaac tttatgacac 11040
agttttctct aaatgatatt cgtccggtcg atgagaccgg tctttcagaa aaagaacttt 11100
caattaagaa agaaaaggat gaaatagcaa agcttcttga tcgtcaagaa aatggattta 11160
tcattgaaaa aatggtagaa gagtttggaa tgagttatct tgaagctaca acagcattct 11220
tggaagaaaa ttctattcct gaaactcaat ttgctaaatt tattccttcg ggtataattg 11280
aaaaaattca gtcagaagct attgacgaaa atcttttacg tccttctgtt gttcgttgtg 11340
aaaaaactaa tacattagat tttctactat gattaaactc cgcatgcctg ctggtggtga 11400
aagatatatt gatggtaaat cagtttataa attatactta atgataaaac aacatatgaa 11460
tggaaagtat gatgtaatta agtataattg gtgcatgcgg gtgtctgatg ccgcttatca 11520
aaagcgaagg gataagtatt ttttccagaa gttatcagaa aaatataaat taaaggaact 11580
tgctttaatc tttataagca atctggttgc taaccaggat gcttggattg gtgacatctc 11640
tgacgctgat gcacttgtgt tttatcgtga atatatcgga cgcttaaagc aaattaaatt 11700
taagtttgaa gaagatattc gcaacattta ttattttagt aaaaaagttg aagtttctgc 11760
ttttaaagaa atctttgagt ataatccaaa agttcaatca agttatattt ttaaactact 11820
tcaatcgaat ataatttcgt ttgagacgtt tatcttgctt gattcgtttt taaatataat 11880
tgataaacat gatgaacaga ctgataattt agtctggaat aattattcta taaagttaaa 11940
ggcttataga aaaattttaa atattgattc acaaaaagct aaaagtgttt tcattgaaac 12000
tgtgaaatct tgcaagtatt aattgcttat tataaataga ttataattat ctcactgacc 12060
agctatgagg tcatacatcg tcatagcacc aactgttaat taaattaaaa aggaaataaa 12120
aatgtttaaa cgtaaatcta ctgctgaact cgctgcacaa atggctaaac tggctggaaa 12180
taaaggtggt ttttcttctg aagataaagg cgagtggaaa ctgaaactcg acaatgcggg 12240
taacggtcaa gcagtaattc gttttcttcc gtctaaaaat gatgaacaag caccattcgc 12300
aattcttgta aatcacggtt tcaagaaaaa tggtaaatgg tatattgaaa actgttcatc 12360
tacccacggt gattacgatt cttgtccagt atgtcagtac atcagtaaaa atgatttgta 12420
taacactgac aataaagagt acggtcttgt taaacgtaaa acttcttact gggctaacat 12480
tcttgtagta aaagacccag ctgctccaga aaatgaaggt aaagtattta aataccgttt 12540
cggtaaaaaa atctgggata aaatcaatgc aatgattgca gttgatgttg aaatgggcga 12600
aactccggtt gatgtaactt gcccgtggga aggtgctaac tttgtactga aagttaaaca 12660
agtttctggt tttagtaact acgacgaatc taaattcctg aatcaatctg cgattccaaa 12720
cattgatgat gaatctttcc agaaagaact gttcgaacaa atggttgacc tttctgaaat 12780
gacttctaaa gataaattca aatcgtttga agaactgagc actaagttca gtcaagttat 12840
gggaactgct gctatgggcg gtgccgcagc aactgccgct aagaaagccg ataaagttgc 12900
tgatgatttg gatgcattca atgttgatga cttcaaaaca aaaactgaag atgattttat 12960
gagctcaagc tctggcagtt catctagtgc tgatgacacg gacctggatg accttttgaa 13020
tgacctttaa tagattatat tactaattaa ttggggaccc tagaggtccc cttttttatt 13080
tcaaattttt ttcacaaaac agtttacatc cttgctcttc tatggtacta tacaactatc 13140
ggcaatactg ctgatgatta aagaggaaaa taacatggct aaagttgata ttgacatcgt 13200
tgattttgaa tatattgaag aaattattcg taatcgttat cctgaactta gaatcacaaa 13260
tgtacaagat tctaagtttt gaagtattca aatcgttatt gaaggtcctc ttgaagacct 13320
catccgcttt atggctaatg aatactgtga tggcatggat tctgaagacg cagaatttta 13380
catgggactg atcgaacaat aattattaag gggctatcaa gcccctatta aaatgaggaa 13440
acattatgta tactggtaga aagtatgaac ttgttccaag acttattgat acatttatta 13500
attatagccc acgttctaat tcatcaatag ttaaagctat tcgagataat ggcggatggt 13560
ttgaagttaa agaagtttcc gtcgctaatg gatataaagc agtaaaacac attgaatgcg 13620
ctaatggaaa gcatttttac ctcaaagata gacttttaga aatttgtgaa gacgaatttc 13680
attgttttcg tgagtataaa gaaccgactt ctgaagaaga tgaagtcgaa gacaagattt 13740
ctggcgtaac aaaaattcac tgcattgttg acgaaaacaa tgtagatgaa atcattgaac 13800
ttttgcgaaa aactttcaaa aagtagttta cagaagggta gtagtgtgat actattaccc 13860
tatcaattaa ggagaataaa atgagattac aacgccagag catcaaagat tcagaagtta 13920
gaggtaaatg gtattttaat atcatcggta aagattctga acttgttgaa aaagctgaac 13980
atcttttacg tgatatggga tgggaagatg aatgtgatga atgccctctt tatgaggatg 14040
gagaaagcgc aggattctgg atttaccatt ctgacgtcga tcagtttaaa gctgattgga 14100
aaattgtgaa aaagtctgtt tgaggaaaat attatgtctg acattcacgt aactggaatt 14160
gctcaagtaa acattcgctg tcaatttaaa actgtacctg gggtgactca tattacttta 14220
tcacacgacc catattctcg tggaagacag ataactggcg taattaagtt tttcggtgga 14280
attggcggaa acgaatttac tataggcgat gacgaaattg ttggctgtaa actaaaagtt 14340
caaaagggcg tgttagaact ttttagtgat gaagtttttg atgaaatctc acgagcagtt 14400
aataaaggaa tgttaacgtt aatcaaaatg attaaagcca gtggatatgt tcccgatcct 14460
ttatattagg agataatatg atttttgtat ttgaatttat gaatgatgaa ttcgattatg 14520
caatttttaa cgcattgcat aatcctgatt taaatgaatt taatgaaatg ttttctgacg 14580
ctttgagtat gtcagaagaa tactgcggag actgtcaacg tgtttgtgtg acagtttttg 14640
aaaacaaaga aaagacatat gaagaactat tctttgatgc taataaagcc actgaatggt 14700
ttattgaaag gggcttttag taatgattaa attggtattc gcttattctc caactaaaac 14760
ggtcgaaggc tttaatgaat tagcattcgg tttaggtgat agtttaccat ggggacgagt 14820
taaaaaggac ctccagaatt ttaaagctcg cactgaaggc acaattatga ttatgggtgc 14880
taaaacgttt cagtcattgc ctacattact tccaggtcgt agtcatgtgg tggtgtgtga 14940
tattaaacgc ggctatcctg aaactaaaga tggtgatttg gctcattttt atattacctg 15000
ggatgagtat gttacattag tagccggtgg acgtatccaa ttatccagtc ctaatacaac 15060
ttttgaaacg tttatcgatt ccagcgaaaa tcgcatcagt gtaattggcg gacccgctct 15120
gttatatgct gcattacctt atgcagatga agtagttgtt tctcgcatcg ttaaaagaca 15180
tcgtgttaat tcaacggttc aattagatgc aagttttctt gatgatataa gcaagcgtga 15240
aatggttgaa acccactggt ataaaataga tgaagtaaca acccttacgg aatcagtgta 15300
taaatgaaat aacgcgtggc ggaaaatatg aactttaatt attatcctat tctattagaa 15360
aaagacgcga aacaaccaaa atggcagggt cctcagttta ttaaaggcgt ctatcaatta 15420
gtagttccca aagacaagat ttatagcagt tgtttcactg aatccgcttg tagtattttc 15480
ggtaatagtt ctccgtattg gaattttgat ataaaattgg atagaaatat cgatatttgg 15540
ttgaaagcta tggatattgg caatatcacg tttgatgaga ataattatca tattattggt 15600
cgtttttcca aacgtggtaa agaattatat ttcacgcctg aaattgaaag aaaatttgac 15660
gctaaaccgt attgattatt tagcttcata aaatgtatta taatttatat aaggtactaa 15720
atgaaacaat accaagattt aattaaagac atttttgaaa atggctatga aactgatgac 15780
cgaacaggca caggaacaat tgctttgttc ggtactaaat tacgctggga tttaagtaaa 15840
ggttttcctg cagtaacaac taagaagctc gcctggaaag cttgcattgc tgagctaata 15900
tggtttttat caggaagcac aaatgtcaat gatttacgat taattcagca tgattcatta 15960
attcaaggca aaacagtctg ggatgaaaat tacgaaaatc aagcaaaaga tttaggatac 16020
catagcggtg aacttggtcc aatttatgga aaacaatggc gtgattttgg cggtgtagac 16080
caaattatag aagttattga tcgtattaaa aaactgccga atgataggcg tcaaattgtt 16140
tctgcatgga atccagctga acttaaatat atggcattac cgccttgtca tatgttctat 16200
cagtttaatg tgcgtaatgg ctatttggat ttgcagtggt atcaaagaag tgttgacgtg 16260
ttcttgggct tgccattcaa cattgcatca tatgctgcat tagttcatat tgtagctaag 16320
atgtgtaatc ttattccagg agatttgata ttttctggtg gtaatactca tatctatatg 16380
aatcacgtag aacaatgtaa agaaattttg cgtcgtgaac ctatggattt atgcgaatta 16440
caattaaaat ttccagatga atttgatgaa tgggacacag aatcacaggt attttggttg 16500
agtcaattcg caaagccgca taattttgtt cttaacaact atgtatctca ccctcctatt 16560
aaaggaaaaa tggcggtgta attaattatt aattgtgagg atatatgatt ttacgattta 16620
aagatacttc tggtgtagtt ctttttacac ttcctaaccc aagcgagtta gaagttccag 16680
gaccaaatca gcctattatc atttatggca aaaaatatta tactcataaa atgactcgtg 16740
agtattttga taataaaatt tctacggtta aaacttcttc agattgttat tatgatatta 16800
ctgttttaac ggaaaaacaa tatgacgaat tatcaccgcg cgggccgtct atgccaagta 16860
gtgaataaat ataaatccga ctttgatgtt aatattcacc gtggtacatt ttggggaaat 16920
tacgtcggta aagatgctgg cagccgggag gctgccattg aattattcaa aaaagatttt 16980
atacgttgaa ttaaatccgg agaaataact aaagcacatt tagagccttt acgtggaatg 17040
aggctaggat gcacatgtaa accaaagccg tgtcatggtg atataatagc tcatatagtt 17100
aaccgattgt ttaaagacga ttttcaagtt gaggacttat gcaattaatt aatgttatca 17160
aaagtagtgg tgtttctcaa agctttgacc cgcaaaaaat tattaaagtt ttatcttggg 17220
cagctgaagg aacatctgta gatccttatg aattatatga aaatattaaa tcatatctcc 17280
gtgatggaat gaccactgat gacattcaaa ccattgtaat taaggctgct gcgaattcta 17340
tttcagttga agagcctgat tatcaatacg tagctgcgcg ctgtttaatg ttcgctcttc 17400
gtaagcatgt ttacggtcag tatgaaccac gttcatttat tgaccatatt tcttactgtg 17460
taaatgaagg taaatacgac cctgaactgt tgtcaaaata ttctgcagaa gaaattacat 17520
ttttagaatc aaaaattaag cacgagcggg atatggaatt tacttattcc ggggcgatgc 17580
aattaaaaga aaaatatctc gttaaagata aaaccactgg tcaaatttat gaaactccac 17640
agtttgcatt tatgactatt ggaatggcat tgcatcaaga tgaacctgtt gatagattaa 17700
aacacgttat tcgtttttat gaagcagtat ctactcgaca gatttcactg ccaactccta 17760
ttatggctgg ttgtcgtact ccaactcggc aatttagttc atgcgttgtt attgaggcag 17820
gtgattcgct gaagtctatc aataaggctt ctgcttcaat tgttgagtat atttctaaac 17880
gagctggaat cggcattaac gttggtatga ttcgtgccga aggttctaag attggcacag 17940
gtgaagtacg ccatactggt gttattcctt tttggaaaca ttttcagact gctgttaaat 18000
catgctcaca gggtggaatt cgtggcggcg ctgctactgc ttattatcct atttggcatt 18060
tggaagttga aaatcttctc gttttgaaaa ataacaaagg tgtagaagaa aaccgtatcc 18120
gtcatatgga ttatggcgtc cagctgaatg atttgatgat ggaacgtttt ggaaagaacg 18180
actacattac tttgttcagt ccgcatgaaa tgggtggcga gctttattat tcttatttta 18240
aagaccaaga ccgtttccgc gaattatacg aagcagcaga aaaagaccct aatattcgca 18300
aaaagcgtat taaagctcgt gaactgtttg aattgctcat gactgaacga tcaggaacag 18360
caaggattta tgtgcagttc attgataata cgaataacta tactccgttt attcgtgaaa 18420
aggcacctat tcgtcagagt aacttgtgct gtgaaattgc tattccaaca aatgatgtga 18480
atagtcctga tgctgaaatt ggattgtgca cgttatctgc atttgtgtta gataacttcg 18540
attggcaaga ccaagataaa attaatgaat tagcagaagt tcaagttcgc gctcttgata 18600
atcttttgga ttatcaagga tatccagttc ctgaagcaga aaaagctaaa aagcgtcgaa 18660
accttggcgt aggtgttact aactatgcag cttggctggc aagtaacttt gcttcttatg 18720
aagatgctaa cgatttaaca catgaactat ttgagagatt acagtatgga ctcattaaag 18780
catccattaa gctcgccaaa gaaaaaggac cttgtgaata ttattcagac actcgttggt 18840
ctcgaggcga attacctatc gactggtaca ataaaaagat tgaccaaatc gcagctccaa 18900
aatacgtttg tgactggtcg tcgctgcggg aagaccttaa gctctttggc atccgtaata 18960
gcacattatc agcacttatg ccatgtgagt catcttccca agtttctaac agtacaaatg 19020
gtatcgagcc tccacgtgga ccagtctcgg ttaaagaatc aaaagagggt tcctttaatc 19080
aagtcgtgcc caatattgaa cataacatag acctctatga ttatacatgg aaattagcta 19140
agaaaggtaa taaaccttat cttacgcagg tagctattat gctgaaatgg gtatgtcaat 19200
cagcttcagc gaatacatat tatgacccgc agatttttcc aaaaggaaag gttccaatgt 19260
ctgtaatgat tgatgacatg ctatacggat ggtattatgg cattaaaaac ttctattatc 19320
ataatactcg tgatggttcc ggtactgatg attacgaaat agaaactcca aaagccgatg 19380
attgcgcagc gtgtaaattg taatgaatta tcaaaaaatc tataatgacc taatttcccg 19440
agctcaggct cgggaatctt tatcagaata taaagagaca catcatataa tccctagatg 19500
tatgggaggt tctgatgata aggaaaattt agttgaatta acagccagag aacattttat 19560
agctcattta ctactatgta agataaatga aggccatttt gggcttgcct ctgcgttaac 19620
gttaatggca acagataaag ctggcaatag aattaataac agattgtaca gcttacacag 19680
aaaattattt gctaaagcta attctgagtt ctttaagaaa tattggaaaa ataatcctca 19740
tcctaaagga atgttaggca agcaccataa aagcgaaact aaacagcatg tatcaaacgt 19800
gaatagatat gcatgcccat ctatagaaat acataaattc tcattagatg gggatttcat 19860
agaaaccttt cactctattg cggcagcgtc ccggtcagtt aatggaaacg ggtcaaatat 19920
caaatattgt gccgagggta aatttcaata tgcttatgga tttagatggt catatcaact 19980
tgatgcaaag tttgacaaaa taaaaccaag agattataaa ggaatccgcg gtaagaaatg 20040
gattaataat ggaagtgaat gcacgcttat aggtaaagat gatattatac cgccaggttg 20100
gaaacacggc agaattttaa agaggaaaaa ttaatgtcta cagtttttaa tacaaatcca 20160
gttgatgttt taaaagaacc catgttcttc ggttcaggtc ttggtattgc gcgttatgat 20220
attcaacgtc ataaagtttt tgaagattta actgaaaagc agttgtcatt tttctggcgt 20280
cctgaagaag taaacttgat gatggatgct gcacaattta ataagcttcc tcaatatcag 20340
caggatattt ttactaataa cctgaagtat caatcacttc tagatagcat tcagggtcgt 20400
gcaccgtctg ctgtacttat gtcattaatt tcagacccaa gccttgatac atgggttgct 20460
acatggactt ttagtgaaac tattcacagc cgttcatata ctcatattat gcgaaatctt 20520
tatactgatc cgtcaaaggt atttgatgag attgtattag ataaagctat tatgaaacgt 20580
gctgaatcta ttggtcgcta ttacgatgat gttctagtta agactcgtga atatcagaat 20640
gcggttgaag attatgaagg aattttatca gaaggatttc gcaaagaaga gttaggcaaa 20700
gttgttgaat gtactaaaca agcactaatg aaatctcttt acctctgctt gcatgtaatc 20760
aacgcactgg aagctattcg tttttatgta tctttcgcat gtacctttaa cttccataag 20820
aacatggaaa tcatggaagg taatgccaag attatgaagt tcattgctcg tgatgagcag 20880
cttcacctta aaggcaccca atatattatt cgtcaacttc aacttggcac tgatggtgat 20940
gaatgggtta aaattgctca agagtgtgaa caagaagcag ttgatatttt catggaagtt 21000
aaccgtcaag aaaaagactg ggcagttcat ttatttaaag atggcgatgt tcctggatta 21060
aatacaaata gcatgtggag ctttattgat tacttaactg tatctcgtat gaaacagtgt 21120
ggtcttccat gcccaattac cgatgctccg gttaaacatc catatccttg gattcgtgaa 21180
taccttaatt ctgataatgt tcaatccgcg ccgcaagaag tagaactgtc atcttacctt 21240
gttgcacaga ttgataatga tgttgatgat aaagttatga tgagttttaa aaaatatttt 21300
taaggagtgg gccgcaaggc ccattttatt atgaaagaaa ttgcaacaga atattcattt 21360
attaaatata ctgagctaga attagacgac aacggaagta taaaacaatt atctattcca 21420
aacaagtata atgtaattta tgctattgct ataaatgatg agcttgttta tattggaaaa 21480
actaaaaatt tacgtaaaag aataaactat tatagaactg ctattaaccg taaagacaaa 21540
acgtctgatt ctactaaatc tgcattaatt catgctgcgc taaaggaagg aagcaaagtt 21600
gaattttacg cccgccaatg ttttaatctt tctatgacaa atgagttagg tacaatgaca 21660
atcgcaacga ttgacttaga ggagccgcta ttcattaaac tgtttaaccc gccttggaat 21720
attcaacaca agaaaaaatg atgcttccac atggagtgtg gtactatatt caaaacacaa 21780
aagaggatac acaatgcaag aactttttaa caatttaatg gaactatgta aggattcaca 21840
gcgtaagttt ttttactcag atgatgtaag tgcatctgga agaacttaca gaattttctc 21900
atataattat gcatcttatt ctgattggtt acttccagac gcattagaat gtcgtggaat 21960
tatgtttgaa atggatggag aaaaaccggt aagaattgct tctcgcccta tggaaaagtt 22020
ttttaacttg aatgaaaatc cattcacgat gaatatcgat ttaaatgatg ttgattacat 22080
tctaacaaaa gaagatgggt ctttggtatc aacttattta gacggtgatg aaattctgtt 22140
caaatcaaaa ggttcaatca aatctgaaca ggctttaatg gctaatggaa ttttgatgaa 22200
cattaatcat catcagttgc gtgatagact taaagaatta gctgaagatg gatttactgc 22260
taactttgaa ttcgtcgctc cgacaaatag aatcgttctt gcttatcaag agatgaaaat 22320
cattttattg aatattcgtg aaaatgaaac aggcgaatac atttcatatg atgacattta 22380
taaagatgct gttcttcgtc catatctagt tgaacgatac gaaattgata gtcctaaatg 22440
ggttgaagaa gctaaaaatg cagaaaacat cgaaggctat gttgctgtga tgaaagatgg 22500
ttctcatttt aaaattaagt ctgactggta cgtgtctctt catagtacaa aaagttcgtt 22560
agataatcca gaaaaattgt ttaagactat tattgatggt gcatcagacg atcttaaggc 22620
aatgtatgct gatgatgaat actcatatag aaaaattgaa gcatttgaga cgacttatct 22680
gaagtactta gaccgagctc tgtttttagt tcttgactgt cacaataagc attgcggtaa 22740
agatagaaag acttatgcga tggaagcgca aggcgttgct aaaggtgctg gaatggaaca 22800
tctgttcggt atcatcatga gcctttacca agggtatgat agtcaagaga aggtcatgtg 22860
tgaaatcgaa cagaattttt tgaaaaatta taaaaaattt atcccagaag gatactaagt 22920
tgtttacaag tcccttatgt tgtgttacag tagtcttact gacataacat gaggacttta 22980
tgatggattt acagcttatt actactgaga tggtcgttga agcatacggt gatactacag 23040
atgggatttc tgtatttaaa ggaaatcgtc gagttggata tatcactgat cttaagaaag 23100
atttagctaa gcaagttaag cggaaaacga ccattaaaga atatcgaaat cgtcgtcttg 23160
agcaagcccg tgatatgctt cctgatgcgg ttgaggagat gaaagtcttt ttagaaaatc 23220
agcttgcgaa atatgattgt gatgtgttca ttaatcagac tcaacctaat gttcatatca 23280
ataactgtaa atgctacatc atcgtcaatc ctttgacaga aaagcatcgt cttggaatta 23340
gtaatccaaa tcgtagtgca tcagatatgg cagaagatgt tgaggcatgc tttaaaattt 23400
ctaaatctcc agctgaacat catattttaa ttaacggtct ttctcaagac gatattgtag 23460
aggttattaa aactttatgc atgtaagtaa ttttacagct ggattgctat tacttgtaat 23520
agcatttggc ggaacatcta ttattttaaa aaataaggta gaaagattag aaacatcggt 23580
tactgaaatt acaaaaacag ccaatgaaaa cgctttagca ttagataatt tgcgaattca 23640
gtataattat attgatgcga tgaataataa aaatcgtgag gcaattgctg ctattgagcg 23700
tgaaaatgaa aaactgcgca aagatgcaaa gaaggcggac gtggtggctc gtaagccagg 23760
attggttgaa aaacaaatca acaactcctt caacaagttc gcagaagaca tccaggacct 23820
ttctaaatga ttagactatc agcagtaata ttatctatcg gtcttctagt tggttgttcg 23880
acaaagcctc tagaagtaaa gaaagaaaca gttcatccta attggcctgt gcaaataaag 23940
tcatatgacg aagctaaact atcttggcaa gttaaagtta ttgatggtaa agcttgggtc 24000
ggtatgccat ttgaagattc ccaggaattt cgcatttggc ttaatgatgt aaaacgatat 24060
gtacatgacc agaaaactat gatatgttat tatcgtcaag agctaaaaga ggataaatgt 24120
aaatgatttc atggcatcaa tttgaacatc tcaaaggatt gatttatgaa tccgagatgg 24180
ctgcaatgat ttatgggcgc cagattcaac gattagaatc tttacctcca actaatgatg 24240
ttttattagc tcaatctcgg gctaatctta aaaatgaata tcaaaataag tggggtaaag 24300
catctaaaga cctgcatgat tatattcaat cattggttga gaaaaataaa tgaaaactct 24360
gctagaacgt tatattgaat gctcagaccg ttacattgac gtatgccgtg aaaatgtatc 24420
aagcattagc gaagacattg aacatgctaa agctttagat gacgctggta aagctttacg 24480
aaaagaagca aaagcccgtg ggcttgatat gtatcagctt aaaaatcaca tgataaaatt 24540
tatttcatct aatgttcaga gcaaatcggt gaatcaatca acagctgaat tatataaaga 24600
gcgacgtgag cataatattc gtattcttga agttttctta ggaattaaat gatgaaaaag 24660
attattttga ctattggctg tcctggttca ggtaagagca cttgggctcg tgaatttatt 24720
gctaaaaatc ctggatttta taatatcaat cgtgatgatt atcgtcaatc catcatgggt 24780
catgaagaac gtgacgagta caagtatacc aaaaagaaag aaggtatcgt aactggtatg 24840
cagtttgata cagctaaaag tattctgtac ggcggtgatt ctgtcaaggg agtgattatt 24900
tcagacacta acttgaatcc cgaacgtcgc ctggcatggg aaacttttgc caaagaatac 24960
ggctggaaag ttgaatataa agtgtttgat gttccttgga ctgaattggt taaacgtaac 25020
tcaaaacgtg gaactaaagc agtaccaatt gatgttttac gctcaatgta taaaagcatg 25080
cgagagtatc tcggtcttcc ggtatacaaa gggactcccg gtaaaccaaa agctgcaatc 25140
tttgaccttg atggaacatt agctattcat acatctcgtg gcccatacga attagataaa 25200
ttatcaaccg atattccaaa cgaaatggtt gtacaatatc tgaagatgct tcatcactca 25260
ggttatgaga ttattactgt aagcggacgt gaatctggca ccgaaaatgc taagttaaaa 25320
tattatgtta tgacacgtga gtggctttta caaaacgata ttccgtttaa tttgcatatc 25380
caacgcaaac aaggtgatac tcgtaaagat gatgtagtta aagaagaaat tttctggaaa 25440
cacattgcgc ctaattacga tgttaaactt gcagttgatg accggaacca agtcgttgag 25500
atgtggcgtc gtatcggtgt tgaatgctgg caagttaacc atggtgactt ttaatggctt 25560
tgcatcatga aacttgggct attgttattg taaacagtgg tttagttggt actagtaatg 25620
ggcaattttg tgtattcact agtgaataca gagcttggga ggaatgtctt aaattaagag 25680
aaaagaatcc tgatgttgaa ctaacagtaa agaaaactaa actgccttta ccatggaaaa 25740
cttatgaata atctagaaaa gatttatcgt ctttgtgata aaattgaaaa agaaaagaaa 25800
tacttatttt gtctatggcc tattgttgac ggaagagtgg gtttagatgt tcttgattat 25860
gaaacagaag acaaagtaga tggttcaact tttgataatg cgttggatgt tattgattgg 25920
cttgaagaaa attatgtgag gtaaatatgt ttccgactta ttctaaaatc gtagaagtag 25980
tgtttagtca aattatcgct aataacatgt ttgaaaagct tgataatgca gctgagcttc 26040
gaattcatgc tcaagtgact cacgtattga acgctttgct tccagaccaa gttgattcta 26100
ttgcaattac gctgtatcca ggttccgcgc atatcattgt cgtatttggt cttgatgctg 26160
agttagttat caaaggcgat attcgttttg aatcgcagac atcagaattc aaagcaattt 26220
aatagtttac tttacggtag agttgtgata ttatagctct accaaaacaa atgaggaaat 26280
tgaaatgagc gaatggtttg aagaagataa ggtttatcgc tttaaagctg gatataaaga 26340
tatttttaat gaaacttgcg gagctaataa acgaattgcc cagtttattg gggaaaattc 26400
atttaaagta aaaatagatc ctgcgaaaaa tgttattagc attaaacgtg aaattgatga 26460
ttgctggtat aaagctgttg atgtaatggg tgaatcctat aaagttagtc cgttattttc 26520
aattgcttat atgttagaat attctttttt cgaagaagtt caaaaagatg attctgtcag 26580
taaatttgaa attaaagctg ataaagaaat taaatggaaa gtagtaggta ttactggttg 26640
tatgttctat atctatgctc aaactgatac gaaggaagaa gctaaaaaga aagctctaga 26700
atatcttgaa gagtatgaag aaggtccggt aatgattact caagatgccg aattagtttc 26760
tgtcaaatta gttaaaaacg ttgaaagtat ggagctggga tcaacatgct aagcgaaaaa 26820
ccaattactg ttaaagaatt ccaagaaaaa gttaaactat ttgctcagga attggtaaat 26880
aaggtttctg aacgatttcc tgaaacatcg gttcgtgtta ttaccgaaac tcctcgttca 26940
gtattagtaa ttgtgaatcc aggtgatggt gaccaaataa cacatctcaa attggatttt 27000
gatggattag ttgaagcaca aagggtgtat ggcgtactat gatgaattta actgatataa 27060
ttgataattg tcttgaaaat gatactggcg atcatagagc gcttgattct gaaacagcac 27120
agttcattag aataacttta atgaatgata ctctagtgaa tagtattcat ccttctgtgt 27180
atgatgctat tattgtgacg aagtatccag ttgagcttca caaaaagatg gctggtgcaa 27240
tttttattga taagaaaaac cgctttaaag atgggcagaa tataattagt tctgttatta 27300
aaagtataac taaacttcgt cacgaaattt atcgtgttga aactgctaaa tctgcttatc 27360
tggtgattat gaaatgaaag cgagtacagt acttcaaatt gcatatttag tatcacaaga 27420
atccaaatgt tgctcctgga aggtaggagc agtaattgaa aagaatggac gtattatttc 27480
tactgggtat aatggttcgc ctgcaggtgg tgtgaattgt tgtgattatg ctgccgagca 27540
aggttggttg ttgaataaac ctaaacatac tatcattcaa ggtcataagc ccgaatgcgt 27600
atcatttggt tcaactgatc gttttgtttt ggcgaaagaa caccgtagcg ctcactctga 27660
atggtcgtct aaaaatgaaa ttcatgctga actaaatgcg attttgtttg ctgcacgaaa 27720
cggttcttca attgaaggtg ctactatgta tgtaacactt tctccttgcc cagattgtgc 27780
aaaagcaata gctcaatctg gaattaaaaa gttggtttat tgtgaaacat acgataaaaa 27840
taaacctggc tgggatgata ttctgcgaaa tgcgggtatt gaagtgttta atgttcctaa 27900
gaaaaacttg aataagttaa actgggaaaa tatcaacgaa ttctgtggtg aataatgaaa 27960
tttcgtttgg tacaactcac agcaattagt tcttattcca acgagaacat ttcatttgct 28020
gtagagtata agaagtattt tttctctaaa tggaagcagt attataagtc agaatgggtt 28080
tgtattgata gaccgtatag ttggaaatct gatttagaaa aatgccaaaa attgctttcc 28140
actcttaaag aacgtggaac aactcatatt aaaactgtga taggtaaata aatgaaactg 28200
acgactgaac aaaaagtagc aattcgtgaa attttgaaaa ctaaattgtc catgggtatt 28260
tcaaacgtgg tttttgaaaa gtctgatggt actattcgta ctatgaaagg tactcgtgat 28320
gcagacttta tgccaaccat gcaaaccggt aaattaactg aatctactcg taaagaatct 28380
actgatatga ttccagtatt tgatgttgag cttggtgcat ggcgaggttt ttctattgac 28440
aaattgattt ctgttaatgg tatgaaagtt gagcatttgc ttcaatttat tggtaaataa 28500
atgctttaag aattatttgt tattattaat tcatctgtta acaaaaagga aaaacgatgt 28560
ctgaagtaca acagctacca attcgtgctg tcggtgaatt tgttatttta gtttctgaac 28620
ctgcgcaagc tggtgatgaa gaagttacag aatcaggact cattatcggt aaacgtgttc 28680
aaggtgaagt tcctgaactg tgtgtagttc actctgttgg tcctgatgtt cctgaaggtt 28740
tctgcgaagt tggtgatttg acttctcttc cagttggtca aattcgaaat gttccgcatc 28800
cttttgtagc tctgggtctt aagcagccaa aagaaattaa acaaaaattc gtaacatgtc 28860
attataaagc tattccatgt ctttataagt gatataaata ataatatgaa ttgggtgtcg 28920
gaataataag ttaaccgaac aattctatgt ggtagtctac aactgagaga tctgtcgaaa 28980
gaagatgaaa ttcagaagaa cgtgactacc gagttttaat ctctaacgag aatttttaaa 29040
tgattaaaca attacaacac gctcttgaac tgcaacgaaa cgcatggaat aatggtcacg 29100
aaaactatgg cgcatctatt gatgttgaag ccgaagctct tgaaatcctg cgttatttca 29160
aacatctgaa tcctgctcaa actgcattag ctgctgagct tcaggaaaaa gatgaactta 29220
agtatgctaa gcctctggct tctgctgcac gaaaagcagt tcgtcacttt gtggtaacac 29280
tgaagtaatt atgttgacga ggtttatggt tatcctgtcg gtaaatattc aaaacctaag 29340
taccccttga gggctttcgc aggcaatgcc aataagtcct gcattttcac ttaaaagaga 29400
atttataatg gcaaaacaag ctaaagcaaa gaaagcagtt gaaaagaaag ttggtgattc 29460
taaacgcgct ggttacaagc gtgggtcgaa ctctcgtatc aatcaaactg ttgagaagat 29520
catgcgtcga gcacgtgcgg ttcttcgaga tgatgcttct cgttttggta agcagaaagc 29580
ataagttgag gactccttcg ggagtccttt tttattttcc aaagattaca caaagttgtt 29640
tacagtatgg ttcctttgtg atagtattat cttacacaaa caaaggagaa taaaatgaaa 29700
acgattaatc tgaacgctgc ggttaaagct aaatgtttca atggtgaata taacgaaact 29760
atgtggttct taatggcagt tgaaggtgat attgttgaag tagaaacaac agaaggtatg 29820
ggaacagatt tcacctttac aattcaagtt cataatttct ttactggttg gatttatgaa 29880
ttgaatacag taatcgttgg aaaaattgaa caaaatgaat taggtgaatg gtattatgtt 29940
acagctcgcc aacgtgccga acgcttaatt gagaagatga aaaaagttgg taaacttgac 30000
atgcaacatt ggaaagtagt aaaataattg tttactttgg tacaggatat gatattatat 30060
acctgtaccg caattaaaca tctcggagaa taaaaatgaa ctacatcaac tttgaacgta 30120
aatatgtttc taatggtatt gcaggttcta ttgatactat ctgcctttgg aaacatcaaa 30180
atggatcagt atgcgaaatt gaacagtata tgactcctaa ctacgtttat atgcgatttg 30240
aaaatggcat cacggtttca atcacgaaag aaggttcttc ctttaaaatc gcattagatg 30300
atgatttccg tcaacgtgat ttaggtactc atccttgttg gaatggcgtt aatcgcaagc 30360
ttctggttaa aacttggatt cgtcatattc tgagtaacag agctaaacct gagcatcttg 30420
aagcaatctt tgatgtagtt cttaacgaat ttgatattta aaaataaatg aggggcttcg 30480
gccccttact gaggaaaata ctatgtttat gactacttat tttgataccc gtaaaaattt 30540
ctgtgaagtg gttttctcaa aggcgcctaa aggccttcct gctcatttgc aacctaccag 30600
tgaatcgatt aaaaactacg ttaatgtagt atgtccttta gagttccgta ctgtaaatgg 30660
acgtgatact ctagcaatca ttaaactcaa tcgtgaaatt gacattgacc cttcaattgc 30720
gcgtgaaatt aatatttctg acattggtgg tggtaatgtt aaatcgcacg gatttcagat 30780
gaggttctaa tgaaattctt tttgggtcaa actgttgaat taaagggagt cggtatacct 30840
ggattaattt ctaaggtttt gcctgcattt aaatggagag acgttcaaat aaaagaggct 30900
tatattgttt cctgggtaga tggaaatgaa gaccttcgta tgggtgatga attatctcct 30960
atctatggat taaaggaatt agtatgaata taattaataa gatttttgga attcagtaca 31020
ttaaggtcac atataaagta acgtataaag gtccgtatac cgatgaacat gaagaaccac 31080
aagttaagtc tattatatta gaaaaggacc ctaactggcc agttgaattt cgtcttcctt 31140
gctatggtca ttgggctgat gttgaaatta taagtattga aaatgtctga gctagagata 31200
agaagcaatt ttagatggcc atcatgtgca ttaagcaatt tcgcccaatg gcctttcgtt 31260
atggatggta tccaatttgg aggtcttgaa ggattcctcc aaggatgtaa ggtgaaaaat 31320
gttgaacagc aaagacgtat atttgggatg tccggattgg atgcacaaaa agctggacga 31380
gcttatgcta gagctcagga ccgtgggacc ctcttttggc ttggagttcc gttttcaaga 31440
tactctccag catggaaaga attatacaca aatgcatatt ttgaagcagc aatccaaaac 31500
aggggctttc gtgatgcatt acaagcctcg aaaggaaaag ttttgaagca cagcatggct 31560
agtggtctaa caaaagatga tacaatacta accgaagctg aatttattga tgtgttaaac 31620
ctattaagag actctctatg aagccaacta ttttaactga tattgatgga gtatgtttaa 31680
gctggcaatc aggccttcct tattttgctc agaaatataa tcttccatta gaacatattt 31740
taaaaatgat ccaagatgag aaatttattt ctccaggtaa actctttaat tgtgacgaag 31800
aacttggcgt caagttaatt gaaaaataca atcgttcaga ttttattcgt tacttgtctc 31860
cgtataaaga tgccctgtgt gtaattaaca aattaaaaga agattataat tttgtagctg 31920
ttacagcatt gggtgattct attgacgctc tgttgaatcg tcaatttaat ttgaatgctc 31980
tttttcctgg tgctttctcg gaagtaatga tgtgtggtca tgattcttca aaagaagagc 32040
tgttcaaaaa ggcaaaagag aaatataacg taatttgtta tattgacgat ctcgctcatc 32100
actgcgatca tgcgagtgaa atattaaatg ttcctgttta ttggatggct cgaggagagc 32160
gtgacaatat tccaaaaact gcgcagcgag tttatacatg gaatgatgta gaaaataagc 32220
ttttttcgcc gaaggaaaat aaagaaagtt ttgatagtga aaaagctata aaagatttaa 32280
ttgagaagat ggttaaaaac gattcttttc cttggaacac tacctggaga acgcctggat 32340
taaatcctta taatcatcta tatcatccat atcagacaca tccgtttcag acatggaact 32400
atattaaacc tggtggcata gagtatttgt ataatagacc tactagtggt gataatattt 32460
ttcaaggagc attctaatgt ttgttgttca tactatttat gaaaatgaag gtaatactac 32520
acgtgattac ggccacgtaa atcaattttt tagatgcaat ccagaattcc gagctcaaaa 32580
agacgaacga atttttaaaa aatgtgtaga acaaggtttc atttacgtca agcactggat 32640
gcaaggaaat aaagttagaa ctacatatca taagtctttg cctgagctta atgatgaatt 32700
gatttataat agagctgtaa accaaaccct gaaggatgag caatgattct taaaattctg 32760
aatgaaatag catctattgg atcaactaaa cagaagcaag caattcttga aaagaataaa 32820
gataatgaat tgcttaaacg agtatatcgt ctgacttatt ctcgtgggtt acagtattat 32880
atcaagaaat ggcctaaacc tggtattgct acccagagtt ttggaatgtt gactattacc 32940
gatatgcttg acttcattga attcacgtta gctactcgga aattgactgg aaatgcagca 33000
attgaggaat taatcgggta tatcaccgat ggtaaaaagg atgatgttga agttttgcgt 33060
cgagttatga tgcgagacct tgaatgtgga gcttcagtat ctattgcaaa caaagtttgg 33120
ccaggtttaa ttcctgaaca acctcaaatg ctggcaagtt cttatgatga aaaaggcatt 33180
agtaagaata tcaagtttcc agcttttgcg cagttaaaag cagatggagc tcggtgtttt 33240
gctgaagtcc gaggcgatga attagatgat gttcgtcttt tatcgcgagc tggtaatgaa 33300
tatttaggat tagatcttct taaggaagag ttaatcaaaa tgactgctga agcccgccag 33360
attcatccag aaggtgtgtt aattgatggc gaattggtat accatgagca agttgaaaag 33420
gaaccagaag gcctagattt tctttttgat gctcctgaaa tcagtaaagc taaagagttt 33480
gccgaagtag ctgaatctcg tactgcttct aatggaatcg ccaataaatc tttaaaggga 33540
actatttcag aaaaagaagc caaatgcatg aagtttcagg tctgggatta tgtcccgttg 33600
gtagaaatat acggtcttcc ggcgtttcgt ttaaaatatg atgtacgttt ttctaaatta 33660
gaacaaatga catcaggata tgataaagta attttaattg aaaaccaggt agtaaataac 33720
ctagatgaag ctaaggtaat ttataaaaaa tatattgacc aaggtcttga aggtattatt 33780
ctcaaaaata ccgatggatt gtgggaaaat gctcgttcaa aaaatctcta taaatttaaa 33840
gaagtaattg atgttgattt aaaaattgta ggaatttatc ctcaccgtaa agaccctact 33900
aaagcgggtg gatttattct tgaatcagag tgtggaaaaa ttaaagtaaa tgcaggttca 33960
ggcttaaaag ataaagctgg cgtaaaatca catgaacttg accgtactcg cattatggaa 34020
aaccaaaatt attatattgg aaaaattcta gagtgcgaat gcaatggttg gttaaaatct 34080
gatggccgca ctgattacgt taaattattt cttccgattg cgattcgttt acgtgaagat 34140
aaaactaaag ctaatacatt tgaggatgta tttggtgatt ttcatgaggt aactggtcta 34200
tgaaagctta cttagaaaca attgtcgtgg ctcaaaaaga aggtggagat gtttctactt 34260
ctgtatcaca aatcgttctc gaatttgtag atgcatatgc ttataataaa tttacagaaa 34320
catttgatgc ctatgaaaaa ggtccaaagt ttgaaatata tcgtactctc ttaccattag 34380
attattaaag gccttcgggc ctttaatttt ataaatagaa taaacactag agaggatatg 34440
atggaactca ttacagaatt atttgacgaa gatactactc ttccgattac aaacttaaat 34500
ccaaagaaga aaataccgca aattttttca gttcatgttg atgacgcaat tgaacaacca 34560
ggctttcgtt tatgtaccta tacatctgga ggtgatacta accgtgattt aaagatgggc 34620
gataaaatga tgcatattgt tccttttaca ttaactgcta aaggttcaat tgctaaatta 34680
aaaggtctcg gtccaagccc aattaattac atcaattcag tttttactgt tgcaatgcag 34740
acgatgcgcc agtataaaat tgatgcctgt atgctccgta ttcttaagtc taaaactgct 34800
ggtcaagctc gacaaattca agttattgct gatagactta tccgtagtcg ttcaggtggc 34860
agatacgtcc ttcttaagga actctgggat tatgataaaa agtatgcata tattcttata 34920
catcgcaaaa atgtatcact agaagacatt ccaggagttc cggaaattag taccgagctc 34980
tttactaaag ttgaatcgaa agtcggcgat gtttatatca ataaagatac tggagctcaa 35040
gtaactaaaa atgaggcaat tgctgcatct attgcgcaag aaaatgataa acgttctgac 35100
caagctgtaa tcgttaaagt taaaatttcc cgtagagcaa ttgcgcaaag tcagtcatta 35160
gaatcttcta gatttgaaag cgaattattc cagaaatatg aatctaccgc agctaatttc 35220
aataaacctg ctacagctcc tttaattccc gaagcagaag aaatgaagct tggaattaat 35280
tcattagctt ctaaaactaa ggcagcaaaa attattgccg aaggaaccgc agatgaactt 35340
cactatgact ataaattctt ttcaaaaagt gaggttaatg aagtttctga aaaaattaaa 35400
gatgtaattc tcaatgcgat taaaaatgaa ccaaccactt caataaaatg tttagagaag 35460
tatgcagcag ctattaataa attctttgaa gaatataaag ataattggct tgataaacat 35520
aataaaaccc gtaaagggca gtcagatgaa gtctgggaag aaataactaa aaattcctgg 35580
aacgcagcaa aaactaaatt cctcaaacga atgatttata gcttttctgg aattggtgca 35640
ggtccaatga ttgatattac tattgcccgt gatggttcta aatatactcc atcacaaaag 35700
cgcggcatta gagagtattg tggttcagga tatactgaca tcaataatct tcttttgggt 35760
cgttacaatc cagaacgata tgatgtaatg agtgaaaaag aaattgaatc tgcgataaat 35820
aatttagatt cagcttttga aaatggtgac cgtataccag aaggcattac agtttatcgt 35880
gctcaaagta tgactgctcc tatatacgaa gcgctagtta aaaataaagt gttctatttc 35940
agaaattttg tatctacttc tttaactcct atcatttttg gacgttttgg aattacacat 36000
gctggtatcg gtcttttaga accagaagct cgtaatgaat taacagttga taaaaatgaa 36060
gaaggaataa ctattaatcc aaacgaaata agagcgtata aagaaaatcc tgaatacgtt 36120
aaagttcaaa taggatgggc aattgatgga gctcataaag ttaatgttgt atatccagga 36180
agtctcggaa tagcaacaga agctgaagta attctaccac gcggattgat ggtcaaagtt 36240
aataaaataa ctgatgcttc taataatgac ggaacaacat ctaataatac aaaactcatt 36300
caagctgaag ttatgactac ggaagaactc accgaatcag taatttatga cggtgaccgt 36360
ctaatggaaa ctggtgaagt agttgcaatg acagatgata ttgaaataga agacagagtt 36420
gactttgcat catttgtttc atcaaatgtt aaacagaaag cagaatcatc tctcggaatt 36480
attgcgtctt gcatagatat tacaaacatg ccttacaagt tcgttcaagg ataaatcatg 36540
gaacttatta cagaattatt tgacggcgct tcggcgccgg ttgttaactt aaatcctaag 36600
cataaaatac ctcaaatttt tgctattcaa gcaggtgaag aaagcgtgct tcctggattt 36660
agattttgta catacacctc tggcggtgat acaaacaaaa acgttaagcc aggcgataaa 36720
atgatgcata tcgtaatgat aggtgtcaat gagaaactat cattagttaa acttaaaaac 36780
ttgggtggaa atccaattgg tgtcattaat gcggtttttg atactgctct tcagacaatg 36840
aaacagtaca aaattgacgc atgcttattc cgcgtactaa agagtaaaac aaatggcgca 36900
gctcgacaaa ttcaagttat tgctgaccgt ttagtacgta ctaaaggagc aggtcgatat 36960
gttcttttaa aagaaatctg ggactatgat aagaaatatg catatattat ggtttaccgt 37020
aaaaatgcca atttagaaga cattccaggt gtacctccta tttcaactga gttattcaca 37080
aaagttgaat caaaggttgg tgatgtttat gtagatgtta aaacaggtaa tgctgttcct 37140
aaagctgtcg ctgttgccgc ttctattgct ttagaaaatg ataagcgcac ggatcaagct 37200
gttattcaga aaactaaaat tagtcgtcga ttagcagcac aagctcaata ttctactgtc 37260
gatgcttcgc ttcagggtga tagcttcgct gctaagaaat accaagagtt tgaatctaaa 37320
gttccggtat ataaagcaga aggaccaatg aactccggcg ttattcaggt tggttcaaac 37380
ttcagcaaag gagctatcgg tggtatgaga agtgcttctc gttttaaatc taacgattat 37440
gaactagaaa gcttccgaaa tcatattgca ttggcacatg cacgtttacg tgatccgtct 37500
atcagactgc aaagcgatat aacatatcaa ggttctcaag aatatttaaa gaataaagaa 37560
ttctttgatt ataaaaccga taaaatttta agcgatcttg ctgacattaa tatttctaat 37620
agctttgatg ttattaagaa aattgtcaat gatttagtta aaggttctaa agccacgcca 37680
gatgaaaagg tagctattat tcaatttgtc atgaatggca tttataaatt gattaatgag 37740
tctgcttctc aagcgtatga atatgcaagt actgaagtac ccccaaaagg attaactcag 37800
gctgagtctg atgtaattga agattattgt gcagattcat atgttgaaat gaactcattc 37860
ctcttgggta aaccagattc tacccgtgaa gaatacatgg aacgagctat taaacacatc 37920
gagacaatgg attctgcctt tgccaaagga tcagttcttc ctccaggaac tacactttac 37980
cgtgggcaag aagttacctt taaaacttta cgtcataata ttgaaaataa aatgttctac 38040
ttcaagaact tcgtatccac atcgcttaaa ccaaatatct tcggtgagta tggtaaaaac 38100
tatatggccc tagatgattc cagtgcagta ttttctggtg aaggagaagg ttcagttgat 38160
gctgaagatt taatgcatat gggtagtcat tccgcatatg ctaatgaaga tgctgaaact 38220
agcgtaggta tggtaattaa aggggctgag cgaattaaag ttatcgttcc aggtcattta 38280
tcaggatttc catcagaagc tgaagttatt ttaccgcgtg gaattttgct gaagattaat 38340
aaagtgagta cgtacatgat gaaagaaact gcttataaca agtatctaat cgaaggcaca 38400
atcgttcctc cttctgaaca attagaagaa tcggtatatg atggtgacca tctgatggaa 38460
actggtgaag ttcgtccaat gactgggttt aatcaattcc ttgtagaaga atcaaaagaa 38520
gaggaaaacg aagtttctca aatcttggct tctttggtta acatcaacgg aatgtctaaa 38580
aagttcaaga tgtagtttac aagtcactcg cgttgtgtta taataatctt actgacataa 38640
catgaggaac acaaaatgaa atcttctttg cgctttttag gtcaagaact catagttgaa 38700
ggcgttattc ctgctgataa cgcttttaat gaagcagttt atgatgaatt tattaaaatt 38760
tttggaacag ataaaaagtt cggaattttt ccttctgaaa atttttcaaa gccagaacag 38820
actgaaagca ttttccaagg tgtagtaaca ggtaaatttg agtcagaagc tccggtaaaa 38880
attgaagttt atattgaaga cagtttagtt gcttcagttt ctgcttttat ttcattccgt 38940
aaataaaaat atggggaccg aaaggtcccc attgttatat tgctcctaat attttacttt 39000
gcgaattgac aattcctgtc atagtattaa tgtttgaaat gcttcctgca gttcctccta 39060
atctactaag tcgtgaaagc gaattagata gtccagtaac acctccacta tttccgagaa 39120
cgctttgaat accatttata gtagcagatt caagccattc aagagcagct tgtctatcaa 39180
ccgctccagc ctgcatgact ctatacgcaa aagtaacatc aaatgtagtt atttggttat 39240
ctccatcgta tgataactca ggagcgctca ctgacactgg aatgcatcca gtgaacatca 39300
cagcagtatg aggtaatcca ttacgagcat gaagattaac ctgaatgtct gcctcgacat 39360
cttgtggcaa agcacgcagt ccagttactg ggtcttgaac agcgttaacc cagtcttgca 39420
ttgcacgata attacacgac tctgaatcca ttctaaatga aataaccaaa gggtctaatt 39480
ctcttccggt tatgcgaata ttaggagaat tatagttcca gtcagtttca taggataatc 39540
tattctctgg catttttacg gagtatatca tcaatccaga tgagttatat gccatgttaa 39600
agaaatcaat taaatatgta ccaactgtaa atgagcccaa taaactttga actgtacgtt 39660
gactcatggc accaataaga tatttactaa cccctgattt tcttatcagt ttttgtgtgc 39720
cagctgtaat tagcgtggta attccctgat taatatcacc ttgagtcaat cctaaccaat 39780
ctgaatttag gcccaagtta ttataagaaa agttgctaat tgaacttatc aacgaagagc 39840
ttttagttga tggagttgtc gcaaaaacgc agctaaacat attattacgt tggaaatctg 39900
cgtttattgc ttgattatta aattcctcta aagaatacat taaaaagtcc ccgcatataa 39960
agaagcacgg tttaacgtga taatttctct catagtaatc tcaagagtaa atgtactagg 40020
gaggtttgga gcaatagcta atccgttaaa gttaccatta ggcgttttat caaatctgat 40080
gctttgtatt tggcatggac caaatatttc agtttttcca tcaaacttag atgttgcacc 40140
aaagtttttc accatccaaa ttgtcgggtt tgaaactact aggacgttag ttaaactcga 40200
tgtcattttc tcaaatagtg ttttattttt agctgcgtct tccggagata aaggttcaat 40260
taacgtagaa cgataccaat catctaaata cccctttatt tcagcagcat attgagattt 40320
acccgtttca ccataagaaa aatagttaaa atattgatag atattaataa tagccattaa 40380
atcttctgtt gaacgtggag tcaaatccca tgtaaacact ttagttctat tctcagcacc 40440
accatacata cttctggctg tggtataaat ctgttcatta ttatcagcca ttataccttg 40500
tgttatactt tccagtgctc caaatactgc agttgaagca atattactta gcacaccagt 40560
agcagttcct ccgcctctac tgataagact ttcttgaaca tcattaaatc tatgtgatga 40620
tgtatcaacg tcagatttag atctcggtaa aagaatgttt gccacaggag ctttacttat 40680
tgttcctgaa ttattatctg atattaatcc atttgacagt tttgatactg tattactgat 40740
agtgtttctg gctgtacgta aaatactcga agatgaagaa gagtagttag atctcatcga 40800
tctaagactt ccagaatccc tagatgacat attgtatgca gtaaataata atccattctt 40860
atatagatct gttacctgga agtcccctgt agtgtcatta ccactagcac gcccagttgg 40920
aaactgggct gtgtatgttt tagttgttac ttctgattta gtactctgtc cggctgaaat 40980
tttctcaccg gactttttaa ttaaatcagc agttatttct ttaacaattg ccatattatt 41040
ccttaattaa ctccagtcgc atcaaataca ccaggagcag tcgtgctcgt tacgggtgtc 41100
atattatgaa cgacagtatt tttcttaata acattattag tattattgat tgaaggagat 41160
gcttgttgaa caggagcttg ttgtgctttg ttcttttcaa taacctggac ttgttttgct 41220
tctggcgatt tagcagaagt ttcaggtttg gcattaggct gatttttctt gagctcttga 41280
taagtagcat caattttaga aaatctagca gcaagttctt ttttaactgc cggcgaatta 41340
tttaaatccg ggtcatccat ccgtttttta aggtcttcat aggcagcttc aactgattta 41400
accgttgaat ctttactcat atcagctgaa tcggcatatt gatcaaaacg attcatagca 41460
gcacgagctt cattagcttt cattaaagca attttagctt cctccggaga aagttgcttt 41520
aatttttctt cttcctctgc cctctcttca tcagtcgtta gtgcttcttt attatcaaca 41580
ccacgaatcc agttagatgc acgagttttc cagttcgcaa ttttgtctag tccttttgct 41640
atcggaccaa ggtctccatt cattctttta tattgataat ttgcaacttt ttcttggtct 41700
tctttgctaa gagaagcatt tgtagtattt tggaaatttt ctagtgctct tccttctact 41760
tcatcagcgg tatccttcat accaggaata actcgaagaa ttgccgcaga taatttagcc 41820
attccaagct gaataagttc tcctaaatta taaagaacct ttccaagccc ttctacaata 41880
gctaccgtca aaccgcccca atctcccgct tcccagaatt ttttaatttc atcaatagaa 41940
ctaaagatgc tctgtaataa aggaccccat gttccggttt cgctagagaa tttagtaaag 42000
tccgtactaa acaaatccca agcctgtgaa aatttatctg accaatattt gaaatgaacc 42060
atcaacaggt ctattccaac aacaacagcc aatatcattg cagtcatttt agcagcttca 42120
atagcagcac tgacggtata cttaaataac atgcttgata ttttatcagt aattgaaata 42180
gattttttaa atccaaaatc aacagtcttt gttaatttat ctaaagcttg agataatttt 42240
aagttaaatg cgtctttttt ctgtttttct tctggcgatt cttgtttggg ctcaactggc 42300
tgaggggtag ggaaaaaatc agcatcagga tcattattaa ctgcttcagg agctggtaat 42360
aaaggaccca cagattcagc tgtatcgtcc tcaacaactt taacaggaat agcgctttca 42420
actgtggcta aactagttcc agtctgttga attccagctg tctgaatttt ttgctctagt 42480
aaacttgtta atttatctaa tttgctcccg agtgattcac cgatttcttt attaatatta 42540
ttgccaattt cgacagtttc agcaattaac tcagaaccag cagtagtatc actcactgcg 42600
ctttctacac tgtcaattgc tccaattatt tcattcgatt tttcttcgac agtttgagca 42660
attaattcag aagcagcttg agcatcatcc aatttcgtag atatatcatt aagtccagat 42720
aaagtgttgg aagcggattt agccgcttcc tgtgttggtt tattatctga aataactttt 42780
ctacgcatcg tttgcatttc ttgtggcttt ttcattcaaa taatccaata atattgccaa 42840
ttccagttat tggaccatta gggccaggaa ttgctaaagt tgtaaaaatg tcatttgccc 42900
attttaaaac gaatgctggc atctcaagaa aattaatttc tttaacttca tcattgacct 42960
taagcaagca tttggataac atatcgctca cagttaaaaa ttgttcaaat tttccaggcg 43020
gtctaaaata aaatgtattt ccttggtttg aaattccaat ctttggcata cataaacatc 43080
attaatgtca taagtataac catctatttc tttacgagat ttaatctttc cattaaattc 43140
caataaatga atagaaacga aatcaacttc tgccggtgat aaattcggac aaatagaatc 43200
aataagaagt tttaaatttt catcaggacc tttaacatct tttaaaatgt tataatgttt 43260
aagacccatt ttaggaatag aaacttcttt attgcttatt ggaagaacta ctttcttcag 43320
tggtagtatc agatttaaat tcatttttaa ccttaactgg gtctattgtt tccagtttcg 43380
ttgcattagt gaacatatat agatgagtta ctgaattatt attggataat tcatggatga 43440
cttcatcaac gtaaaattct gttttaaatt ggtttttatt atcattaaaa ataattttaa 43500
cgccaggtgt caagttaaaa ttaccgacag tagaacattt agcatagcca tcgtattgcg 43560
ccatagtttg aagacgaata gcttcttcat atccattcct ataagtcatt tcagaataag 43620
cacccgacct tgacactaca atagagtttt cgccctttcc tgtagtaatc attggcaatg 43680
aagaatccaa aaacgaatgc gcatagatag tagcgttttt cattgggtca cgtttgtgag 43740
gattcgattt agtcaaccaa acgaaatcat atgccaatgg atattttaat tcttggatga 43800
attgacctat taaagatggc tcaccgacaa tcattggata cggttcttga tttatcatca 43860
tatcatagtc catcatgtta actcccatga tgtcttgcca tacaaataca aatttgtcac 43920
ttcctacagc tagagcaact tctctgacat atgacaaata gttttcaaat gtactagtcc 43980
acggaatatc aggaacataa gcatttatag catttattgc tggagttaat aatgtgcggt 44040
cttgataaat gacgccaagc atttccttta tagattcacc tgcatcaggg aaaaacggtc 44100
tgccaaattt aagattttct atagaatgaa tagttcccaa ttcaatagca atgatgttat 44160
caccctttga atctactgac acagaaaaat gcttacatcc ataaattctt gttttaacat 44220
tattaatatc gtttgcatta gctacagaaa tctgaattat ttcatttcca tccatttttg 44280
tatggatgtt tttagaatca taaaactgca gcattccttc atttcggcca taaagagaat 44340
cccgcatagt taatgtggta atagtagcag ctaattcaac aaatctatta ttactccaag 44400
cgtcgtagct atcaaataat ttaacgctga gatttggata tccagggcgt tgcaacatac 44460
tcattattgt ttatccttct caatcagttt taatacgaat ccgcgctcgg caggaatcat 44520
tttcattatt gaatttaagc tataattact ttttacgagt gtgtgattaa tttgataaaa 44580
agtaaatatc tcatctgggt taactaatag cttaaacaca tctactatat cagtgtattt 44640
ttttacatac ttattacaac acgacatgtg caatgttaaa ttaataggat tcattgcatc 44700
gagaattttt tctaatgttt ctatctcgat ggcatcaaca agttctattt gacttgattc 44760
actaatttcc ttccaatcat accatgtttc atctacttga acagaatgaa tattttcagt 44820
aatcatcttt gctttatttt cataaaactc agaaggaaac tttaatttaa ttttaacatt 44880
agctacatca aaaacaggtt cctttaattc tttttgatat atttcaaatg gaactgtctt 44940
ttctttttta cattttggac atacaaatgt gaccggtact ttagttttac ctattgatcc 45000
tacaaatacc tgcaaaaata taaatggttg ccaagtcttc ggatagtctc caaaataatc 45060
ggcaattaaa tcagcaatta tttctttttg ttcttgtggt gaccgatgtt ctatatcgtt 45120
tcgaactaac aaaaaatctc gataatcttc taccgtaaat ggtttaaaac gatgaacacc 45180
atctggtaat ttacaacgaa taatgtttgc catagatgct ccttttattc tatttataaa 45240
tatgataaat aaaggagcta aatatgtatg aatacaaatt tgacgtgaga gttggttcta 45300
aaataatcaa ctgtcgcgca tttactctta aagaatatct agaacttatt actgctaaaa 45360
agaacggttc agtcgaagaa attgttaaaa agctaattaa agactgtaca aatgcaaaag 45420
atttaaaccg tcaagaatca gaactcttgt tgattcattt atgggcacat tctcttggag 45480
aagttaatca cgaaaactcc tggaagtgca cctgtggaac tgaaatacca acccatataa 45540
atctattaca tacacaaata gatgcaccag aagacctctg gtatacactg ggtgacatta 45600
aaattaagtt ccattaccct aaaatttttg atgataaaaa tatagcccac atgatagtat 45660
catgcataga aacgattcat gctaacgggg aaagcattcc agttgaagac ttaaatgaaa 45720
aggaactgga agatttatat tctatcatca cagagtcaga tattgtagct ataaaagata 45780
tgcttttaaa gcctactgtt tatttggctg ttccaattaa gtgcccagag tgtggaaaaa 45840
ctcatgctca tgtaataaga ggactcaaag aattctttga gctattgtaa tggcaaatat 45900
taataagctt tattctgaca ttgacccaga aatgaaaatg gattgggaca aagacgtttc 45960
cagatctctt ggattaaggt caattaaaaa tagcctttta ggaattatta caaccagaaa 46020
agggtcgaga ccttttgacc cagaatttgg atgcgattta tctgatcaac tttttgagaa 46080
tatgactcct cttactgctg ataccgttga gcgtaacatt gaaagcgcag taagaaacta 46140
cgagccacgt attgataaat tagcagttaa tgtaatacca gtttatgatg attatactct 46200
gatagtagaa atacgctttt cggtcatcga taatcctgat gatattgagc agataaaact 46260
acaactggct tccagtaaca gagtataatg cttcacgtat aaacgtggta taatgaatct 46320
aagtccatcc aataacaatt gaatagagaa caatatgaaa ttagaagatc ttcaagaaga 46380
attgaagaaa gatgtgttta tagattcgac taaattacag tatgaagcag ctaataatgt 46440
gatgttatat agtaaatggc ttaataagca ttcaagtatt aaaaaggaaa tgcttagaat 46500
tgaagcacag aaaaaagttg ctcttaaagc taaattagac tactactcgg gacgaggaga 46560
tggtgatgaa tttagtatgg atcgttatga aaaatcagaa atgaagacag ttctatcagc 46620
tgataaggat gttttaaaag ttgatacttc attacaatat tggggaattt tattagattt 46680
ctgtagcgga gctcttgatg ctattaaatc acgtggattt gctattaagc atattcaaga 46740
catgcgagca tttgaggctg gaaaataatg agatatagca ttgatgatgc ttttaattat 46800
gaagaagaat tcgaaacgga aattcaattc ttaatgaaaa agtataatct caagcgtcag 46860
gatattcgta tcctggccga ccacccatgc ggtgaagatg tactttatgt taaaggaaaa 46920
tttgccggat atcttgatga atatttttat tccaaagata tgggcattga tatgcatatg 46980
agagttatat aaatagatat ataatttaga ggagacaatc atgtcagata agatttgtgt 47040
tgtctgtaaa actccaatcg attctgcatt ggttgttgaa acagacaaag gtcctgtaca 47100
tcctgggcct tgttataatt acattaaaga actaccagtt tcagaaagtt cggaagaaca 47160
attaaatgaa acacaacttt tgctatagtg tgacctttag tctatagttt tggcccttcc 47220
tttttttggt tgggcctttt tttaatttaa aagctttctt ctacttcatc gtctgaatct 47280
tctaattcag ctctttttcc tgccaaagca tctctcacag agatgtcatc agtatctttt 47340
aattcagttt ctttaactct tttcttataa taagcttcaa gttcttctag accttctatc 47400
gtttgacaag aggcaatttt acccataaat tcatcaatag aagcttcata aagaaattgt 47460
ttaaattcta gtaacatctt tttctccaaa gggccgaagc ccttataaat taactgtttt 47520
tctaagtatt cttagtttgt acattgataa tccagtagct ttagaagcat ctttcatgca 47580
tttatactta acaccattta cttctatagg tttagcagct gggttattag ctcctgagtt 47640
atctggcatg ttatctttaa ttttctgaat agatttagcg gaatgtttcc ttccatacat 47700
gccattattt ttacctgatt gattgataga atgcaatctt ttagcttctt cagtccattt 47760
tgttgggttc attcttttag ttttactaat tttacttccc cacgtaattg gacgattttt 47820
catgagtttt gacatatatt gtttatgttc ttccgtatgg tgttttccgt aaaatggatt 47880
accttcacct gattgaagtt ctgccatttt acgacgttcc caggcgtaag atttattaac 47940
gtgtctttca tgagtctttg aattcatccc catacatata acggctttaa ttataccgta 48000
atggtttgga tgaattttag ctaaaagttt atgagctata aaatgctctt cagctgttag 48060
ttctaccaaa ttacacttat catctgtacc gcccatacat ctaggaatta tatgatgagt 48120
ttcagtgtat ccattaaggc gagcccgatt ctgggctcta ttaattaaat tatcgtatat 48180
taatttataa ttcaaagttt aacctctttc atcacataat taaacttctc atcagcataa 48240
cgctgaatac gatcaagtcc atgttttaaa agatagttta aatgcgagta ttttttagaa 48300
gatgtttttg atttagaaac tacgcccgcg tcatctatga ggtcccagac cgttgctatt 48360
gtcttagaac catgcttacg taatacgcga cctattgttt gcaatacaat aattttagat 48420
ttaacgccgt gcgctaaaac aacgtgatgc agatttttaa ctgaaatacc agtagaaaat 48480
acaccataac tagctactat aattattcct ttaccgtttt cagctaaggt tttcattaca 48540
ttgcgcgttt cggtatcaac ttctcctgat acgtaataaa ctttatcgta ttcattttta 48600
attaaatcga aaatagcttt accatgtgat acatgcttaa acatgacaaa agcgttttca 48660
tctttttgtg caagtttaat agctaattta gcgatccatt tatttctttt actgagccca 48720
gtaataattt ttatttcttc ttggtaagtt tttcccttta atttagtagt gaactcatcg 48780
ggatagcgaa gaaaaatact attaattttt aactcagtta cttgtccatc ttccattaat 48840
ttagaagtcg ttactggctt aaatatttca ccaaacattc caacatactg catgatattg 48900
gctttgccat cacgtaatga accggacaaa ccgaatttga acatgcagtt atttaaacct 48960
gatatgatag atgaaatact ttttcctgta gcaagatggc attcatcatt catcatcatt 49020
ccaaactgtg agaaccattc ttttggttgt tttactacag tttgccatgt accaacaacg 49080
actggcgcat catttttata tttatcatct tttgatgctc caccaccgat tttctttatc 49140
attgcatgac tgaataaacg ataatcaaca aagtcatcag ccatctgagt tgtcagagca 49200
gttgttggaa caatgataag aattttacct tcataatttt ccaaataata acgagcaagc 49260
aaagcttgaa ttaaggattt acctgcggat gttggaagat taagaattct acgacgatta 49320
actaatcctt cgaacactgc atctttttga taccagtgtg gttcaattct tttatttcct 49380
gaatagattt ctaacttaga aagccattca tcaaaatctt ttcttgataa ttcttctttt 49440
tcgttaatct gtgggtcaat ccaagcttta tagccaaagt tatcacagaa ctttttaatt 49500
tgcccgacta agccgaatgg aagaagacga ttataatcta aaagacggat tcgtccatcc 49560
cagttgccat atctgaagcg aggattaaat ctatatccat cggcctcaaa cgaaaagaaa 49620
tctcttaatt cgtggaacgt gctctcttca caatcgatgc gtacatgact gaagtcgtga 49680
aaatgtactt taatatccat aattatgcct tactaaattt gcctttagaa tctcttttca 49740
tgagacgacc tttaataaat ccgtcgggaa taataccgtc tggttgtatt aatttattta 49800
ttgcaccatt attgacccaa aaagttcctg tggtagtcgg tttgacttta catccttttc 49860
tggactttct attaggatga accatccctt ttacaaatcc ttctggaaca agttctccag 49920
gtttaataaa aatattttta gttccattag tgtaacaagt tgtacctaat accgtgcccg 49980
gtgagttttc aaatctctta gcggaagatt ctttcatctt tgctataacc tctgtagtca 50040
taacaattcc accaattcca ccaggtttca tattataata atttttgctt tttattattt 50100
caggagttat aatttcttct tcatacatgt acgcttcttc ggaagtttta aactctttta 50160
gtattgttct agagaaattg ttttcaccat atttctttat agcctgctga attgccttac 50220
cggaaccaag gtagccatca ttcaggtcgt cagtagagtg ttttcctata tactttttac 50280
catttattag atttgttgtt tcatatacaa agtggtacat actattttcc gagtaataaa 50340
tatatctata tttatactga ggaaatatta tgatagataa agattatatt gcagagctga 50400
aggctcttga tgataataaa gaagctaagg ctaaattagc tgaatacgct gaacagtttg 50460
gtataaaggt caaaaagaat aaatcttttg ataatatcgt taatgatatt gaagaagccc 50520
tccagaagct cgctagtgaa cctatgccag agactgatgg gttatctatt aaagacttaa 50580
tcaatgctgc tgatgctgca gagggattaa aatatgacga tgaagaagtc aatccagcgg 50640
cagcacttct gattgattct ccggttaaat ctgacattaa aattgaagta gtagaaaagg 50700
ataaaattcc tgaaaatacc gatgttttga ttgaagatac tccttttgtc gaagaaaaat 50760
tcgagcaggc cgtagctgag attattgaat ctgaaaagcc gtctgtattt actcttccgg 50820
aaaactttag tccgaatctt cagctgattg gaaaaaatcc aggattctgt actgttcctt 50880
ggtggattta tcaatggatt gctgaaactc cggattggaa atctcaccca actagttttg 50940
aacacgcgtc agcacaccaa actttattta gcttaattta ttacattaac cgtgacggat 51000
cagttttaat tcgtgaaaca cgcaactctt ctttcgtgac attaaaataa ggataactta 51060
tggcttttac agttgatata actcctaaaa cacctactgg agttatagat cagactcagc 51120
agtttactgc tacacccagt ggtgaaactg gaggcggaac tattacctat gcttggactg 51180
tagatgatgt tccacaagat ggagctgaag caacttttag ttatgtacta aaaggacctg 51240
ccggtcaaaa gactattaaa gtagttgcaa caaatacagt tccagaagct gaagctgaaa 51300
cagcagaagc tactacaact atcacagttc aaaataagac acaaacgact accttagctg 51360
taactccaga tagtccttca gctggagtaa ttggaacccc agttcaattt actgctgcct 51420
tagcttctca accagttgga gcgtctgcta cttatcaatg gtatgtagat gattcacagg 51480
ttggtggaga aactaactct acatttagct atactccaac tacaagtgga gtaaaaagaa 51540
ttaaatgcgt agcccaagta accgcggctg attatgatgc aaaggaagtt acttctaatg 51600
aagtatcatt aacagttaat aagaagacaa tgaatccaca ggttacattg actcctcctt 51660
ctattaacgt tcaacaagat gcttcagcta catttactgc taatgtcact gatgctccag 51720
aagaagcgca aattgaatat tcatggaaga aagattcttc tccagtagaa gggtcaacta 51780
atgtatacac cgttgataca tcatctattg gaagtcaaac tattgaagtt actgcaactg 51840
ttaccgctac tgattatgat agcaaaacta ttacagcaga aggtcaagtt caggtaactg 51900
ataaagttgc tccggaacca gaaggtgaat taccttatgt tcatcctctt ccacatcgca 51960
cttcagctta catctggtgt ggttggtggg ttatggatga aatccaaaaa atgactgaag 52020
aaggtaaaga ttggaaaact gacgacccag atagtaagta ctacttgcat cgttacactc 52080
ttcagaagat gatgaaagac tatccagaag ttgatgttca agaatcgcgc aatggataca 52140
tcattcataa aactgcttta gaaactggta tcatctatac ctatccataa tcttaggggc 52200
ttcggcccct ttcttcattt tgaaagcacg caaaacacaa tcagaaaacg atgtatataa 52260
tggcaccaac tcgataacat gagattgatt atgagaactg aggttgtggt gtttacactc 52320
catgagtctg gaaagtcatt cattgaaatt gctcgtgaat tgaacttaca ggcaaaggaa 52380
gtggctgtat tatgggctcg agctatgact gctaagaata aatttgagac tcgagaaaaa 52440
gttgtctata gaaaaagaca tattaataaa aaggtgaaaa atggaacagt atgatcttta 52500
tgaaaatgaa tattttgcta atcaattacg cgaaaaagca cttaaaagta aacagtttaa 52560
actagagtgt tttattaaag atttttcgga acttgctaat aaagcagctg aacaaggtaa 52620
aacatatttt agttattatt gtaccgctcg cgataaattg attactgaag aaattggtga 52680
ttggctgaga aaagaaggat ttagctttaa agtcaatagt gatcagcgtg atggtgattg 52740
gttagaaatt acattttgag gattaattat gtttaaaaag tatagcagtc ttgaaaatca 52800
ttacaattct aaattcattg aaaaacttta cagtttagga ttgactggcg gcgaatgggt 52860
agctcgtgaa aagattcatg gcacaaattt ctcactaatt attgaacgcg ataaagcaac 52920
ttgtgctaaa cgtactggac cgattcttcc tgctgaagat ttctttgggt atgaaattat 52980
tctaaagaat tacgctgatt ccattaaagc agtacaagat attatggaaa cttcggcagt 53040
tgtatcttat caagtcttcg gcgaattcgc tggacctggc attcagaaga atgtcgatta 53100
tggtgataaa gatttttatg tatttgacat tattgttact acagaaagtg gtgatgtgac 53160
ttatgtcgat gattatatga tggaatcatt ctgtaataca ttcaaattta aaatggctcc 53220
acttttgggt cgtggtaaat ttgaagaact tattaaattg ccaaatgatt tagattctgt 53280
cgtccaggat tataatttta cagtagacca tgctggatta gttgatgcaa ataaatgcgt 53340
ttggaatgct gaagcaaaag gcgaagtatt taccgctgaa ggttatgtat tgaaaccttg 53400
ttatccttct tggatgccta atggcaatcg cgtagcgatt aaatgcaaga actctaaatt 53460
tagtgaaaag aaaaagtctg ataagcctat taaagctaaa gttgagctgt cagaagctga 53520
taataaattg ctgggaattt tagcttgcta cgttacactg aaccgagtaa ataacgttat 53580
ttctaaaatt ggcgaaattg gtccaaagga ttttggaaag gtgatgggac taactgttca 53640
agatattttg gaagaaactt ctcgtgaagg tattacttta actcaagcgg ataatccttc 53700
tttgattaaa aaggaattag ttaaaatggt acaagatgta cttcgtccgg cttggattga 53760
attggtaagt taaataaaaa gggacctttc ggtccctttg ttttattcat caacgataat 53820
ttttggtaat ttaacaccta ataaaacaga caaatctgaa cgacccgcca ttttatccat 53880
gtctccaccg tcaattactc ttgcttcttt ttcatctttt gctacagtgt aaggatttgc 53940
agataaagca tatctaacta ataaaccgat agatggttgc aagctttctg gatcaactac 54000
aactttaaat gcacctacat gttcagggtc atctaagtca agaccttctg tatacggagc 54060
atagaaaatt gatccaacaa tttctttttc accgatattt tctactacgc caacgattac 54120
ataatctaat gggctgttgg tatcgcaata aagcggtaaa ccattagcta agaacccata 54180
ggcattttgt gaaagatatt tgtcatcttc tggtttatgt tttaaccaac ctgatgcagc 54240
aagaatcgca gcagcacgag ctgaagcaac acagaacgtt gctgtataag ttgattcttt 54300
ctggatatgt gaaaccattt cacacaccat tcggtataat gaacgaccgg cttcaggtgc 54360
agatgcataa ctcaaatcaa tgaatccagt atcagtaatt cctgtaactt tatagcgttt 54420
tgacactgta atcaaagact gcagaatatc tttattgatt tcatctgcca tttcggttgc 54480
aagcaaatct tccaagaaat taggagcatc gaatccattt gcttctaaat cttgtgctaa 54540
ttcaactgtg ataccagttt taagtttacg agatttaact gcggtttgcc atttattaat 54600
ctggaatcta gcatcagcaa tttcgctatc agagctttca aatttgctcg ttgacgctgc 54660
gtcagaaaat agacgaacct ttaaaagaac aattgcaatc tgaagagcta attctaaatc 54720
gctttcttca atggtagcaa atggtgtatc ttctaatact ttataaacga tattattata 54780
tttgaataaa tcgcctttat tgagagttaa tttagactct tctgttaatt ctgtgatttg 54840
ttctcggtct acatatccag cttcgccagc gtaagtagca ccagttttaa atgtaaattc 54900
attgtctggg ttaaggtatt tgataccata aaacgcagca acaggttgat tagttctttg 54960
cgttgctaca atgtcagaat atattaattt agtggtagcg cgagtcaaag caacgagatt 55020
tgggcgaccg attgagttgc tattcgttgt ggttgattcg cgcagaagtt cgttgatttt 55080
agccattgcg ctttcctttt ggtttatatg atttatttat accataaaaa caactaaagg 55140
gacccgaagg tcccttaaat cgtcaaagat tagatacctt taacatatac acgtctaaag 55200
taagcgtttt taccaaggct attcagaata gaaggcatac cgctctggat gcgagaagcc 55260
ggagcctgag cagcggattc tgcaaatggg ttgataccga taccgtaacg agttttgaat 55320
cccattactg gttggaagtt cttcggatca gaaccacgca atggagtcag agctacatat 55380
ggagcgtagt aaataccagc atccatttcg ttcggacctt tataacctac agtgaaataa 55440
tcctgtttag catactggtc gatatataca cggtatttac cacccagaac accagcaaat 55500
actgacttgg tagtatcagt gttaaagccg gtagccagac cctgtgcagc ataagaaatg 55560
ccggtatcaa ctgaagccag aacgttaact acgttacggg aagcgataat gaagttacct 55620
tcaccacgac cggtctgacg agcaatttca actgcttctt tgtcaatctg gaacaacaga 55680
gctttaaagg attcacccgc ccagcgagca ccacgaatat caatcggatc ctggaagtca 55740
aatacaccag ctttagaacc cggagtcagg gtcataccag atttaccaac ctgtgcggag 55800
tagttaatcc aatcaacaat ttcacggttg atttccagca tgatttcggt agccagaata 55860
ccagacagtt cagcatcagc atccataccg tgaacagcgc ggaggtcttg tgctaattcg 55920
atagagtaag cagctttcag ctggcgagat ttagcttcga taacttgctt atcgatacgg 55980
aagcccattt cattccatgg gttatcggta gaaccgttga aaccttcctg gagttcagcg 56040
atagaagtag ccataccttc agcgatttct accagtacac cagcttccat ttgtttctta 56100
atttcagcat ctaatttagc tgcgtcagat gcaccagcat cgattgttac tacagcagaa 56160
gcctgcagat acacagtacc agtttcctgg aagaagtgag tatagatatc acctacaacg 56220
gtttgtgtgc tagcagccag agctgggaat ttcttagcag caccctgacc agagaacatt 56280
gcatctggac catacattgg gtggaatgct tctttagcgc cggcagcgat tgggtcttta 56340
ccatatactg cgcgcagtgc gaatacctga ccagttgggc tgttcatcgg ctgaacaccg 56400
caaatatcga aagcaatcag gttaggaata gcacgacgta ccatacccat aacagctggg 56460
ccaatctgag ttactgcgcc agaagtctga cctgcagcga tgttagtagc attgtaaccg 56520
tggtcaccac cgatttcagc ttctgttaag aaagaaccaa atgcctgagc aattttttcg 56580
tctttatact ctggagctgt ctggaaatct ttttcctggt tttcaaagat tttagcgata 56640
atcgcttgtt tgctattagc aatttccggt aaaccttcac cttccagtaa tggcttccat 56700
ttgttcaaaa gttcagcttt agttttgata gtcatttgtg ttaaccttta aaattagaaa 56760
cgagatgcga ctttcgcata tacacttaca atatcttctg caccaggtgc agctttatct 56820
tctacggctt cagtgacgaa attcagtccg gctgcttcag tatcaggagt atttataccc 56880
tcagtaatag tgctttcatc tttattagac ttcttcacca tttctacgat ggcactcaat 56940
ttatttgaga attcatctga ataatccata ccttcgacca gagcagagac tttttctttt 57000
tgagactcag tcagatcttt agtactttcg ctcaatgcca cttcacgctg cacataattg 57060
atatatgcgt cgcgcatatt gagttcttcg aacagacgag ctgattcttc tttatgttct 57120
tgcagctctt cttccatttc agccacaaca tcaactgatt cttctggaac aacaacgttg 57180
tgttcaacaa agagctcttt taatccacca agcatggatt caaacagttc ggctttgatg 57240
cctttatcaa ctgctaattt attttcagcg agccattctt tcgcaagatg gtcaatgaat 57300
ttagaagctt gctcagcgat tttcttctca gctttttctt cggcttcttc tttatttttt 57360
tctacttctt cttctgcttt ttcagcaatt ttagcgatat gagattcagc taatttaacg 57420
gcgtgctgct tgacggtagc ttcgaataca gtgccgaaag tttcttttgc ttccggagaa 57480
atattaactg attcgaaaat actatcaaga gcaacggaag catcaatttt ttgcgcttca 57540
gcaatcagtt gttctttaag cattttgtag tcctgttgtt tagataataa tatttataac 57600
gcttttttca tggcctctgc gagagccata taggcgtcat cggcacttgt atcggcttcc 57660
gccgtctgtg attcggtaat ttccttagga gttacccatg catctggagc acttggaccc 57720
catactgcat caacacctac agttaatttg aatccttcgt ttacgatacg ataaccttta 57780
tttgtgtcag tcaatgaacc taatccacga gaagaaactc ctggaatcca tccggcacga 57840
atattagctg ctaatttatc tccaggaccg tggtcacctt caataacacg agctcgtccg 57900
tatacgtcat ttcctttcca ccacatatct tctataatga tagcggcttg catcgggtca 57960
acattagcgc gtggaggatg atttaattct ccgagagctt gtttagttaa aacttgctca 58020
ttgatatagt cttttaccgc tttttctaat atgcgttttg gataaagacg tttatttcta 58080
ttgacgactt ctgcttgcat gaatattcct tcgatgtata aaccgggttt taaaccgagg 58140
tcttttccat cgtgagattc aagcattggt acaccatcaa taatttcgcc aggttgaccc 58200
caagtttcaa ttagtaattg gggttcattc attagcttaa tcctaatgct ttacggcgtt 58260
taagagcttt tttacgctta cgctgagcac gagattgacc tgctggattg gcaatcttcg 58320
ttttggtagc tttgcgagca atttgtctac gttttgcttt agacagccca gtggtttgaa 58380
atgcattacg ttcgcgtgtt ttgcggtctt tagtacgtgt aatttcacca cgagctgaaa 58440
catgcttaac aatgaattca tttaacggca tattttcatt aatagaagct aatgcaactg 58500
ctaaatcagt ttcatcatca agcatattct cgacaattgt atttatatcg tctttattta 58560
aagcagaaga caattcgtca aagcgaccct gtgcttcagg aataagtgct tcgacattct 58620
cgagaactaa ttcatgagtt tcagggatca gaagcattat tcatcctcgt cttcgtcatc 58680
ttcgtcagag tctttgtctt ttttgtcgtc tttatcatcg ctatcttcgt catcatcctc 58740
atcaggttct tcaccttcga ttaagaaatt acgagcgata gcgatttttt cttctttaat 58800
taaatcaatc gttcttgcag ccatggcttc agcaaagaat ttacgagcgg ctacgaggtc 58860
gtttgattta atagcttcaa ttaaaccttc cattaaaaat cctcttgttc ttggtcgggg 58920
tcttggaaac gagcctcttt agactcttct tcaatttgct tggcttcttg ttctatttct 58980
tcatcagtca tctgcaaaat atctttcata gcagttctgt gagaaatata tttaccaata 59040
aatggttctg ccatggttag catattaatt cttcgttcca aaatttctgc ttctttgagt 59100
tcagtaaagt agctatcccg atgaaattct atcttaatat tatttatttc atcattccac 59160
tcatcttctg tgattatacc tttaagcaac agatttgttt taagcggatc caggaaaact 59220
tcttcaaact tatgctgtaa ctcacgaata aatttagcaa acgttaattc atcacgtgta 59280
atgctagttc cagaatcaaa catcacaccg ccttgttggt cttgcgggat gcgtgaaaga 59340
ggaacacgta atgccatata aagagcttgt ctaaaccaac gaacatcttc catattacca 59400
gtattatcgg caccaggaag agtatcaact tctgtcacag ctttaccatc gcggcgctgt 59460
aaccaatagt cttcggtcat agacatatta tgctgttgat tttttatttt accggtcgat 59520
gcgtcatata ctacacggtt tttcatcgtg ttcatgacat gttgcatgtg ctcagcagct 59580
ttacgagcag gcatattacc tgtgtctaca taccaaacac gacggtcagg agcacgagta 59640
atacgataaa tgacaacagc atcttctaat aattttaatt ggttagcagg tttaacagca 59700
cgatgcaaat acccgatgat atttttacca cagcaatcga ctaatccaga atgggcataa 59760
acgatggcag ctttaggaat ttttattttt gtgccagctt catacattct accatcacat 59820
gcatatgatt cgtgtgcagt atcatatata aaatactctt tgtaaccttt aactattttt 59880
gtgccagctt cagtttctgt tataatttca cgaacatact gaacttgacg agggtctaat 59940
ctacgtaatt cctttatgcc ttcttttgga cgttttggat caataatttt gtgaaagaaa 60000
attcttgaat cgacatacca acgtctaaaa tgatcagaac cttttcgttg aaacgataga 60060
tgatttaata catcgctaaa ttcatctaac atcatatttt taatttttgg gctaaattta 60120
gatttatcca aatttaacgc aacgacttca gtatcatctt catagacgat agcgtctgaa 60180
acaatttctg aaactgcatt atctacttca tagttattca tgagattacg atatgtatca 60240
ataagctcac gagtggtttt cattcctggt tcatatgaac caaaaattgt ttggaatgca 60300
gcattataag gagaagcagc ttcattcgag cttacttcaa attctcttgc tccatcatca 60360
agcttcgggg ctgtaatgga aacaagatct tctttttctt ggtctttaaa atttcgttcg 60420
tccattttag cccatggagc aaacaaactt aatacattaa atttcattgt attctccaaa 60480
tgggaattat agttatattt ataatggact tctctgcttt aagcaggatg gggatttctc 60540
cccattcatt ttattcccaa taatcgagag cgagagttac ttcaaaggtt tggatttcat 60600
tgtttgaatc ccaatctaac tgaagttcac ccacgttagt aggccacaga cctttaattt 60660
caatttcttt tgttactgtt ttagcgtcac gagcatattg gcgtacaata gcgctctttt 60720
tatactctgc tggttttcca ccggtaattt cgtttccttg cccagcagca atgctttgcc 60780
aatcaacaaa cttctgacga gcatcatgtg cctcatcgtt cattactgta atagtccagt 60840
catcgaatgt acgatcgcct gctacgttaa ttttacggtt cataaacccg actggaattt 60900
tttctacaat accagctggt aaagcagtgg ctttacattg aaacgtaaaa ttttgtccaa 60960
gataagaaat ttctacttgg aacaagttag gtcgagcaaa atcaccagat tcaaacgctc 61020
gtgttacatc atctacaaac atattagcct ctgtagtatt tatatcccta tgtttaacct 61080
agggcatata gaattaaaga attaaggata tagtgtattt atatggcctg ccgaaacagg 61140
cctttagaat gcaccgtatt aacctgcaag accagttaac tcatcgaaat ctgcaccagt 61200
agcagttgcg acgaaattca aagtaatata atttatactg cgcgccggtt ggatgtagaa 61260
tgttgcaaca aactcatttc tatcaattac tgacggagtg ttatttgttg tatcgcaaac 61320
tacacgatat tcataaattc caccgagagc tttaattccc tgtaagtact gggcagtttc 61380
tgtgcggaat gatgaacgag taaacgcgtt gtttaattcg aacaaacgat attttgaact 61440
acgtccgata ttcgttttca acatattaaa cagacgacga acgttaatac gatcaaatgg 61500
agaaggaaca gaagtagctg ttttatcacc atacaatacg taaccatcac cacctgtacc 61560
ggttaccggg ttgatagctt cttggtataa acggtcgcgc tgagcttggc gagtttcaat 61620
agccagttta ataacgttca aaatttggcc acgattataa ccagctggag acatccaagt 61680
atgagaaacg ttatcagttc ttgcgcataa accagcaata tcagctgcta atggaaccca 61740
acgattcaca tcattatatt tgtcatactg atacttatag ttaccatcaa ttgccgcata 61800
ggttgaactg atattaaagt tattatcagt gtatgaacct gttgcagttc tccaattgac 61860
taagttatca acagcacgag ttacaggaat tccaactaca gtttcgcgcg gtggtgagca 61920
taatactaag cagtcttggc gagcatcacc aattgaaacg acgtgttttt ggacagtaga 61980
tgctgtttct aaagattcgc cggcgcaaga acccgcaata aacaactgaa catcaacaga 62040
ttcgcggtca gcaaagaagt cccaagcttc catcaaatct cctgctgtta cttcagcatt 62100
tgatgataat ccgccagaca gagttaaaat tccagagaag ccttctggcc agttttgtgc 62160
agttgcgaaa atatattctg aaccaccttt tgcgaaaaag tcatcaatat aaatgttact 62220
atcgtaaata tctttttcac cacgcttcgt tgaaagaaca acgctttgaa caatagcatc 62280
attacgacga actataatag cgtattgcga atcagtttgt ggtccatatc caaacactgc 62340
tttggcagta gatgcacgtg tcccgccacc tggataaatt gggagtaatg cagaagcacc 62400
ttttgcgtag tcagctttag atacgatttc aatttcgatt ttatcgccca actcgcccgg 62460
ataaagagct actactcctg gaattccata tttttcgaga tttgtttgaa attcaaccgc 62520
tgtcatagca gcttcggcat tttcaatttc agctaataaa ataccagaat cagtaataat 62580
ttttccaaga gttattactg cagctaaacc agaggaagac gaagaaattt ccgcggtcca 62640
gttagaacct aatgctggat attcaccaac ttctttcgct ttagcgataa tttttgcagt 62700
aggaatatta attttcttaa tttttccatc agcatctact tcggtaattt taccttccgt 62760
ttcaatgtct tctgaaacat acttaactgt gattttatct ccaaccgcgt agttactacc 62820
tggggtagaa atagtgtatt caatattacc agcaatcgga gatgagtttt tagcggtatc 62880
tctatcgaca gcacgcacaa ctcgcaaatc atttccatat tgtaagaaat tcattgcaga 62940
cataaaatag tcagcagttt cagctgtagg ttgaccaaaa gtattaacta aatctacttc 63000
atttgtaacc tgtttgatct gaaaagcagg accccactgg aatttaccgg ccaaagctgc 63060
tgtaccagta gagttattaa ccacggtgct ttgaaccgta gtttctttga gctcaatgcc 63120
cggagataat aaagtcattt ttaatcctct ttaatatgct ttaatatatt tataccattg 63180
acataccatg agatactgga acatactcag cagaatgaac cgaatcaaca aatataactg 63240
gagcgtattc atcacccata tcttgaagtt cttttgaaaa cacttcagat gctaatcgca 63300
tgtcatcttt gtcggcataa tcaataaatt ttgattgtgt tgataaccat ccaaaaatta 63360
ccaaagacat gactaaatcg tcatgataac cttcttcagc tgcccaagac acaccttttt 63420
cactaaacgt tctaaactct tgaatagttg cacggtgatg aataataagc ttatcttttt 63480
caataaggtc ttttaatgta gagcatccta ctgctttcgt tcgtttagtt tgcttcattc 63540
ctaaatcagt atatgaatcg caaataacgc cttcgtattc taaatccata taaagtgatt 63600
tcgcaactga cacaccagta ctatttaatt caatataaac tgggcattca ttatattcta 63660
ctaaataacg cataacgatg tcaggtagaa ttaaatgaga aattgtgttt gagtgtaaaa 63720
ccccaacttg ttcccacaca tcatcggtga catcaataat atgtaaagca tgataatctt 63780
gtccacgacc ttctgagcag tctagagttg caatatattt tctatctggt tcagggcttt 63840
taaatcgatg aaaaccatga tcatctggtg ttacttcgat gaaatccata acagctaatt 63900
tcattcctga aattagtgta ccagaagtcc cttcaaacgc tgcggtatgt tcttgacgga 63960
attgtgctaa agtggaacca ttaatggttt gtatactcca ttgccatcca tcgtcaaaaa 64020
tatcttcatc attataaaga cgttctttaa ctgaattcca aatagcagtg tatggttcaa 64080
accctgattt accttcaaca gcagcagtcc aaatatcata aaaatgattt aatccattag 64140
gagtcgtagt aataataatt ttcgaacgac gaccagatga aattactggt tgaatagcaa 64200
gccaggaatc atggaagttt ggaataaacg cacattcgtc aatataaatc attgcgaacg 64260
agttaccacg aactgcgtca ggagaggaag cgtaggctcc gattgaggaa ccattatcaa 64320
gttcaataga ccctttattc cattcaacaa ttcctggctg taaaaagtca ggaagcaatt 64380
caattgcttg cttagtacga tctaaaacct ccgcagacat tgagcctttg tgggcaagaa 64440
tacctacagc tttatccttg ttaaaacata caaagtgtgc aagaaaaata gctactacag 64500
ttgttttacc aagctggcgc gatagattac aaacagtcat acgtttagat gacattattt 64560
tgagcatatc acgctgataa tcacgtaatt gaacctttat gacaccatag tcaatgtgag 64620
taatagcaca gtatgtttct gcaaaataaa caatatcatc tcggcatttt ttccattcct 64680
caaccatttc acgagtccat tgtgttttaa tattagctcg tttcaggtta ggaagaccca 64740
tataccgaga tcttttatta ttcttatctt tataggtttg aaataattca ggcttatcag 64800
aattatttgg aatttttact attttgtgta gacgaagata atcactgaat ttttcaggat 64860
accattttcc atcccactgt gattttatcc aatgaattcc atcttcatct tttctttcag 64920
ctaagcttgg gtgttttatt aaaatttttc cagcttcatt taacggatgg aaatcattta 64980
atgcattaat cggttgttcc atttatcacc ttctcacgag cttcttgagc ctcgtaagca 65040
tcaccaattt cgtccattaa ttctgttggt gaacccatga atactgtcgc attctgaata 65100
ttcatttgac ccgtaggaac agcaccttta gtgccaactt gctcagatgt aatatctttc 65160
atatctttat gaagcttcag tatttctctg ttcgtcgtag tcatttgccc cataagagtt 65220
gcaaatactt ccatgtgacg aggagaatca gcattctttg ccgtctcaag aaaaatcttg 65280
gctgcgtcca ttagcatttg ttgttgaaaa tgcatatttc gacgaactac tccataatca 65340
tcttctaagt caggagtacg gttttgagga ttgcttttaa cttctactaa ttgcagaggt 65400
tcatatactt taatttcctc cccgtcaatt ccggggaggt cagaaatatc taaaagtttg 65460
tttatatcaa gaccttccat aataacctct atgttcttgg gccaggaggt tctggcggtg 65520
ttggtctatt tacattgcta gtgaaagttt gttttactgt tccatcccag tcttctgggt 65580
taatatctcg aggaacaact tcgctatcga cagattcaaa aacaccttcg ccatcaggca 65640
aatctcttgt attggcatga aaatctgtat aagtagtacg aattaatcct tctgcatcat 65700
ctaccggagg atacatccat ccatttactt caaatgttag tgaccattca attctacgac 65760
gagataaatt atctccatct atagattcgt ctatagcagc agacatcagt acaattttaa 65820
tatccctttt aaatggaata tcatttccaa actgctcgta catagttgta ttaaaatgag 65880
gttgaaaata tggaagaatc tgttcaacta tttgaaacat atcatcttcg tagcgagtaa 65940
agatactcaa ttcataaatc attttaatag gagatggatt atactgtgat actacagaag 66000
ttgcgccttt ttgtagtaaa ttttgattta aaatgtttgt tttaaatgga gcattatagc 66060
taaaatcaac taaatgtaaa tttatacgag gtagaatagt ttcaacttta gctacatctt 66120
cttgtgaatt tattgatgtc catttattca atttcatcat gaagtgttcc tttgatgcat 66180
acgtaatagg aacacgtata aacttatcac cagattctaa ctgacgtttg atttggatat 66240
ttgaaaacaa atcgcccatc aaggtagcat atcgtctaaa agacgaatta taaaaataac 66300
caaacatgat ttctcctaat ctgggcttta attagtttat aatatttatt aatccatgaa 66360
atcattatca aatgggctag attcaaaaga tttgcctctg ttattgacaa caacataagg 66420
ttcaacatat tctttagctt cagaattaat ttgatctact tcagcatact gatcaatatt 66480
aatatcatga atgccattaa gattacgaac aggatttaat tctaattcac tgaattctgg 66540
aatgttaatt ccttcatttt tctgtagaac cggattaatt tcttctccag aataaatgaa 66600
tttacctgct gtaattttac gaatagcgtt ttggcctaat tgataaaatg gatcatatgg 66660
ttcaacccag ttaatttcga ataagctgtt atccatagga aaatatatca aatccccttc 66720
cttaggttct tttccgttga cttgatgttt aaacaagttt ggattaatgg acaaagtgac 66780
ttcatcctgt acttgcatac caaaattact aaagaatgat ttagctcctt catatccttc 66840
aaatgaattt aaatatgcag cgaatttcca agctttagta aatttatttt ttaagtcttc 66900
gccgaatatc aaatcagggg aaacatactc tcttggaaca taatagcatt ctacacctcg 66960
catttgaatg ctttcagcta ctaatacatc ggccaatatt tgactatttt tataatgatt 67020
gaaatttaca taaggattta gtatttcagt ttcattagtc tgagaataac cagtacgatt 67080
ttctaattta gcaaaaagat ttttatcata agtagccata ttattcgacc ttcttaaatt 67140
tgcaattgtc aaaatggtat cttttagcgt gagatttatc catgatttta gaacagtgcg 67200
ggcattttaa tttttctctg ctatgagata cacccgtgat aactttgcat ttatcgccgt 67260
ggtattttcc ataatttcct acatcacata taattccgca atgcggacaa tttctctttt 67320
cgacttttgc aagaccctta gatagcttat ttaaatactt ttcgtatttt tgggggtcgc 67380
ttttaatctc agaccaaaaa tctttcattt gtttagaaca tctttcttta tattctaaca 67440
tttcgttttc tgataacgat tccaaatatt tcacagaagc ttttcgaata tttgcattaa 67500
cttcttttct cttttcatct gtccataaag atttagtttt tttaatgcct tttccggctc 67560
ttttaattcg ttcatgtttt aaatttggtg atagattcgc ccaaaacttt ttaatggttt 67620
ctgatctaat tttagatgtt tcctctttaa tccatccata atctttactt acaattctct 67680
gctcttttgt acccttggag aattttatta aggcataagc catttcagaa tttcggtgta 67740
ttttaaaaag aagctcatgt gcaaaatagt gttctcttgc tgtcagtaaa accctgtttt 67800
ctttagagtc atctcctccc atggattttg ggacaatatg gtgtgattct gtataataat 67860
ctaatttttt cttattaaga cctcttttaa gagatctttc tataagagag ttgtaaattt 67920
tagtataatt catccaacta acactcccac cggaggatca agcaagtata attcttcgcg 67980
taatgcttct ttttctaatc gagcttcttc tattaaacgc tgtccatcaa ttgtaacacc 68040
accaggaagc atcatgcctt ggtgacgtgc taaaatttgg ccattcagtt ctttagctaa 68100
agctgtagca tagtctttca cccaacgatt attataagca ccttgcttaa catttggatc 68160
ttgaccaaca acgcgaccaa ctaaattgtg gtctgggtta ttatatcgtt cagataatga 68220
ccagctatct tgtggaccga ctgttccata tcctactgta tttccaacca ttttattagt 68280
atcaatatat gatttagtcc agctttctac aataattaaa tcatattttt ggaagtttcc 68340
cataactttg agctgttcat ttgctgaatt aaaccaaaag tctggaatag gcgaaagcat 68400
atcttgcatc attcccatgt aactggtaag ctgggtaaaa taccctaaat cagctccaaa 68460
ggcatttggt ccataaaatc tattacaaga agtccccatg ccaccattaa taccagccat 68520
tcccaaaaga aagtcagtaa accatggata tgtagcgttt ccgtccattg acgttattga 68580
cccaatattc gtgcgcaaaa tgcgagttac tgcgaataca tttgaacctc ttaaatcgaa 68640
gactccggtc ttatattttt cttcgtcatc tcctacataa aatacatgaa aacctttgtt 68700
aagtccatca aaatggtatt caccgtataa ttctagggca cgctggatac aatcataaat 68760
ttgatcgggt gttaactcaa cattaataat tggagcccct aaacgtctta gaatgacatc 68820
tttgagctcc tttggattct gagaattata tcctgacatt taaaatcctt tagggccttg 68880
cggccccatg ttatgctggt gataaaaagg tagaaagcaa tacccattcg ccgtctttac 68940
gaacgtaagc ttgaccatct tttggagctt caggaatata acctgcttct tgtaaagtct 69000
ggacatccct ctgtaatgag gacacattac ctttaatact acgaatctct tgattaattg 69060
aagaaatgtt agtctcatta gcttttattg aattagtcaa tccgcgttct tcgacagttg 69120
aaccattcgg atttgttcca tttactaatt tatttagtgt tacaacttgc cctttaattc 69180
cggaattgtt attaccaatt tcaacctgta agttttgaac atcattgtta agtctattaa 69240
cagaggtttc aacagttgaa actctattta aaagagaccc cggaggagaa ggttgacctc 69300
cgctagaatc agttccaact atctgattta gccatgaaac gttagctctt aaaccggacg 69360
aggtgttttc acctacaatt ccatttaaag attcaataga agtggtatta tctttaattt 69420
gacctttaat actagaagga atatcatctg aaccaatcga tgtttcaata acagttaatc 69480
gctgtttaac gccgccactt ttatttagtt catcatttaa agctgaaatt tcttgactat 69540
tgacattgac atctgtgatt attgaagtat ttcctggata tccaatagaa gttttgatag 69600
atttaatttc ggaactaaga ttaatctgcg attgatctaa attatgcata cgtgaatata 69660
tgctttcact aaatgaagat ggtctttgtc caagttcttg tctaagattt ccaacttcaa 69720
ttgtcagtga acctacatca gattcaataa atttttcttc caaatcactt agacgtattc 69780
cttgggaagt tatagcatct gtattattaa tgatacggtg cttcataccc gtgctgctat 69840
ttcctacaac aggaagacca ttaatatctt gtccagcata ttgccctaat tctcttttaa 69900
tccataacaa atcatttcga actgttctat aaactgaatt tgcgtgttca ttaaatggac 69960
ctatatcaga aagaatgcgg tcaacagtgg catttgtacc atttaatata tcagtgtgtt 70020
cattcgtacg cgtctttaaa tttgatatgt catttttatt aacgctaatc tgtgatagtg 70080
cttcgatatc tccagataca tccaaaatgc cttgaattgt tttaatatct tcctgtgatg 70140
tttcaacggc agttttaaga attcctatat tttcatcaag aacctcaaca tttttaaata 70200
cggacacagt tggtctattc attgatccat cgtttccata cttagtacta gctcctagta 70260
tttcttcacc atttttaatc catgaaatac gctcctgacc ttcgtcagga acgctatcaa 70320
caaaaggtaa atcttttaat tcaatcattt gtaatcctta gtaatgaatt ttaataatat 70380
agtttaatga tatattccat ggtctagttt cataaccaat taatccttca cgattaagtg 70440
taccatgagc atctctcggt ccacctaatt caaatccatc attagtgaag tatgaagcat 70500
tatcccagtc ggaatatttt ctagttccaa gatatccttg ataaactgac gcgccaaatg 70560
ggccttcact tctgttatat tcaccccaac caccagcgtg tttatggtat gacatttgtt 70620
gtgcttgaac accgccaaca tgcattccgt cacatcctac gccaagtcta tccttcccat 70680
aaccatcttg tcctcgttga tttaaaatat gaccgcctgt gccggctcct ctgacgaaaa 70740
gacctcgcat atcaggaata ccaggattat tccaatcacc accaaatctt gttccaacta 70800
cgtttctata atcaggaaat tggtcgcctg acactgttcc accgtgacac atagaccaac 70860
ctggaggtgc tgaatcaccg gcaaacatca taatagtccc aactggaatt ctttcggacg 70920
catatctttc agtggcaaca ggttgatcgc catttttcca cattccgccg cgcgaccaaa 70980
ttccgtttgc tgtaagatgg tctaaattta aagaaccatt aatagtttgt ccaccacgag 71040
tattaattac atctgcgttc catgctaatg ctccagaact atcaccttca ggggcaatac 71100
cggcttgcgt cgttaattta actactccac gcatagaacc ggtagctcct cgaccattta 71160
gtgtttcacc tgttactgca acacccccca aattattatt aatttcagtc tgtgttccta 71220
aacgtataac acccctatat tcatctgttg caacagaatt cataaaggta tacggagaaa 71280
ttgcatatcc ttcgcggaga gttccttgac gagtttgagc gacagttgat aactgaacta 71340
cacctctaac agattctgat gctgtgtctt ctgaaggagc tatttgcgaa attaatttta 71400
ttgcgagttt ttgggttttc aacggagtca tcgccgtagt atcatcaact ccagccaaag 71460
ccgcaggagt tgatgatatt ttaataactc catttgatga ttcagatgaa tacctatttt 71520
ggaatacatc gtcagtatgg tatttcagtt tttgtggcgt tattgatgaa ttattatctg 71580
agccttctaa agtttcttca tttgttgaat agcgtgttaa tccatattta gtttcagtag 71640
catttggata caataatctt gttgctaatg tagctggtgt aacgatttta gaattattag 71700
ttccatctaa aacctcttgc tccgatgcaa tcattgctat tcctttaact tccatagttg 71760
catcaggaat accatttacg ccgatattac ttatttttga taatgctgac tgcactgtcg 71820
tgacagtgtc aggaaaattc gatcctgcag gatcgaattt aacgtatttt gattcatttg 71880
atacgtgctg atatgtattg ttactcatgc tattctctca aaataataaa atactgtagg 71940
ttgggtgtga ctatctagcg taacagtttg cgcacctaat aattgccaag ttccataccc 72000
aggtttagaa ggagaaatta tttcctgttt gaaagtaatt cctttatcag agtattgttc 72060
taagatatgt tcttggttat ctaaatactt aacttgtatt ttatttccta tggtaggatg 72120
gtcttcaaat gaatcaattg caataaattt tgcaaccatt tcctgcagag ctgttctaac 72180
ggcactggta aattcgattg aagtcattcc attagtagct ttaacaggaa tgccaaacat 72240
attaacaata actgggtcac ctggtttggc tgaagtatca gtaacagttc cttcaaatga 72300
ccaatagtct gtttgctgca cgccggtagg agatacgcca cttatattaa ctaatacagc 72360
tccaacctgt tgctctgcca tatttctaac atcattgata gcagattcta catttgagtc 72420
ataaaaacct tttgctattt gtgaaattgt tacagcacct actggctgat tattcataac 72480
cgaaatatca tttttcttag ttctaaaacc aagaaaatct gctaagcggg aaataactcc 72540
cgctttatta ttaagtaaac tcattatgca atccttatcc aacggtatac agtaatagac 72600
ggttgaatat tactaatatt agcaggagga gtatgtgaag agtttgttgt tgcgtagtct 72660
tcacgatatt ttgtatatat aggaccagtt tcatctgggt catattggca acctccaata 72720
ataactgatc cgttttcatc ttcaattaaa actttttcat cagttttagt cgcaggaaga 72780
tttgcgttct caagtgtcac tgatgttgtt ccaactgttc caccggcagt atgcgaagga 72840
tttccgctag aatctaaatc attgttattt aatgcaaagt ttggatccgt aacatcatca 72900
ttccatccta ctaaaacttg tcctttacca aataatttcc atgaaccaaa ccccatataa 72960
gtcaccggat tatttgggtt tatagcattt tcataaattg aaccaatggg ataaatgcta 73020
tcgaaaatag atgatattga attatatgtt ctagtataag aatcaacttt ttcaacattt 73080
ggccaaccga ttttatcaaa atcagttaag gctacgtcac cagtaacttc agtagatgat 73140
cctttgctaa catagcgttc atcagttaat tcaatgatgt catctttttc caaaagagtt 73200
cctaaatcat tattgaacca tgttataacg attatatcac ctgattcaaa ttttctatca 73260
aataaaagac tgatcggttt tccatcttca tattctatag aataatctgt gtttgattct 73320
ttccattcac caccaagaga tatacatcct tcttgtgtat ctgaattagc gccttcacat 73380
aaaaacagag gatatccggc tgttccagct tgttgttgta aaattccatt aaaacgaact 73440
tcaagagaat taggattaat aggttctcct ggaattaatc caaaagcgga aaatggaatt 73500
gatttcatcg tcgataaatc agtaacgtaa atacttcctt ctaatgaagt ctttgatgtt 73560
agttttgaat ctagtacttt tatttggcgt cttgtatatg aacttctcca ttgtgataca 73620
ccatccataa atgtttcaat ttgaacagtg tcaccaatat tacatggctg tcttagccta 73680
atattaaatc catcaagagg aaccaattct ccttcatttt cccctggaga gccaaagtca 73740
ctgttttcgc taaaaacatc gccgtaatac aattcattac cgcggtgttt tactctgatg 73800
ttattaacat tataactagt tccacggaaa atatctaaaa agtctgtttg tccttgaact 73860
tcgactaaaa attctttacg agctacattg ctaatgtctg aactaataat tttgtcaatt 73920
tgtttatttt tgacatattc ccaacgaccc ggagcgcaat aaactagctc taaatcacta 73980
aattgaacgt taatttcaac cgatgacgat gatcctttga tagtatcacc agaagcggct 74040
actaaagtaa ctggattaac attccatgtt gcaaatacat ccctagctct aattacttta 74100
ttataatcat taacagttcc tttaggaagt tgcagtgtta ctcttccaga cgaagtatta 74160
atagcgtatg attttcccca ttcagctttt aatgtttgcc cagatgaagc attataagtt 74220
ttccaggcac cggctgaata tggaacatta ccatcaccaa gttcataata aagctcatca 74280
aagttttcat ttatttttat accaccttta cgcaggtagt caccggtacc atcatctaca 74340
acattaccga tattaatatt ttgtttcatt attgagccac cccgattttc tgcgtagcga 74400
taactttaac tgctgctctc ataccgacag ttgaagaact tatagtcgcc gttacgtaat 74460
tttctttaat actaaatgca atattagcga tttcgtcttc ttctgtttca tttccaactc 74520
gcatgacagc atactcagaa gaaataactt ctgaattaac agtatccaca agaatattta 74580
tttctgctgt tttaattttt cttccatcta ctgattggca cgtaactagc aatttagcca 74640
tattgtattc agtgcgatga aatagtggaa tgtcaactga tccagatgta gaaatattcc 74700
atgtaccttc agcaggtgat tccttttgac caaacatact ttcaatagaa taattccaaa 74760
ccgacgtaga attatcagat gaaatacaac gtaaggtaac tttactatat ggactagtta 74820
ctactaaatt acctgaaacg cctttaattg aatcaatagc ttgaatcgtt aaaggattag 74880
taactgatat tgatccattt gagttaataa attcaacgca gtcgccaagt tcgcctcttt 74940
caatgataac tttaacacct acagtagagg tatcaatatc atgcctagtg ccaactttta 75000
ctggagttgc atactctgca atagagtgtt tttgataata tccagtagca tggataattt 75060
gaccatctgc tccagtgcca tttgctactg ccattttacg ttgatcgcca aacgcgttat 75120
aaattgcgtt aaaatcacta ttaattttat taccaccgtc gaataagata tcaccagtag 75180
aagcgttacc aatttcgccg gtatcaatca atttctttgg ttcttgaatg aacatagcgg 75240
tttccttatg agtttatagt atttataaag aaaaagggag cccatgggct cccttaattt 75300
aaaatgtaaa cagaatattg atttcttctg tctgatccat tgccataata ataggtggcc 75360
tattttccat ataaatcatt tcgcccgaat gcctcattaa atcttccgga tcataataat 75420
ccttttcagc tttaacgttt gggtcatttg gatgagcttt agcttcaaga ggattcgtga 75480
ttattgatat ttgtctaaat cctttatttc ctggcaatgc agcttcagga aaataaactg 75540
aatctaaata tgctttaaaa cggatagtat ttgccttaac acggtaaatt aatccaaaat 75600
catcttgttg ccaagtgaga ttatcttcat atccccatct agtcgggtct tcttttaatt 75660
cctcaggcca aggaaccacg atgtattcat tcgtacatct atttatagat acatcaggcg 75720
gaatctcaaa taaatattcc caaacatatc cgtccccagg ttcaattgtt ccttcagcat 75780
ctcctcggcc ttcaggagga gtcattgacc tagcagaagg agtccatttt ccacctaatt 75840
taagacattc atccttatta gttaaagatg ctattgagca cattccagta tcaggaacat 75900
ctaaacagcg atacactaac catcccgcgc ctgattcagt agcgttgtaa ggagctgagt 75960
tacacactac aatatcgtta attctaaatg tgtatggatc cggatatcta gtatctcccc 76020
aatctcgacg aggaataact gcatcaagca tagatggaag aaccttcacg gttcccatca 76080
tatgagtcca catgtcagtt acacctaaca cagaatcggt gggataaggt ggggcaaatc 76140
ccacctcatt ttcgtttgat gaccacggtt ctgatcttcc aaatgtaata aagatagtgt 76200
ttttatccgg accacttcca attgaattat aaaaattcaa cattttttct gttctaaatt 76260
ttgaagtaac tatcgcacga tagataacac ttgaatcatt catctatttt aacctgtgtt 76320
ggattttcag ggtctcttgg atttcctata ttatctttta gacgtttatt aactaaatcc 76380
ctaaattgtg caaatgttgt tccagatgca tcaaatagag gactcattaa tttacgtcgt 76440
tcagacggca attgaccttg aaatattgaa ttattatttt cagcattata gtcatcagga 76500
agaggatatt ctacgccagc cattgggcca ggttcataaa ttgcttcgcc tgttactgaa 76560
tcatgctcaa tttcaccggt tggagtcaat ttagctactc tatcagcgta ttcagtaggc 76620
aatccagaat cccatttata gtttttgtat ttattaatta tagtctctgt atgtttaaga 76680
gttaaaccaa cattaataaa cattgttaaa agggtaattg ctataaatcc aaatcctact 76740
ggatgaacaa aacgaataac gtcagatttc cagcgggaag aaggtaaatt ggatttaatt 76800
ttcattacat aatatgatct acttctatta atatagtcta tattattttg aagcaaatcc 76860
tttcctttaa ccccgcgaat aatttcgcct tcgaaactag ggagtctttc tgctttaact 76920
tcttgaccgg caattaatct tcccaaaaga ttatgaatag ttacggtcca ttgcaatttg 76980
ccattggaat agcttctttc tatataagta acattacatc ttcctgtagc tgtataaatc 77040
gtttgtccta ctaaatcttc agtcaaagaa tcagattgaa cgattatatc atattcagta 77100
ccagccccag attcaatttc aatttcaact tcttcattat aaagaacttt aaaaagaaat 77160
ttgtatgatg cttcaattcc tttagtagaa taaaaatcat agctacgtga ttcaaaaaat 77220
cttgcaacag catcacgttt atcagcattt aaataaatgt ttcttttata tatctctgac 77280
cacaaatatt cccacgcgtg ctcttctcgc ggatattggt tacgaattaa atttcgtaaa 77340
ttattatact gagttccata tccatcggaa agatactgaa tatatgcctc gcagaatgcc 77400
tcaaaattag aatcctgtag caaataagaa tcaggcatca ttgtgccaat caatggtctt 77460
aaatcaggat cagccaatcc atgctcttct tccggggacc aaggagtttc acgctcttgg 77520
ttttgtaaaa atgcttttaa aaatatttca gttggcttcc aaattatttc aaccgtgtct 77580
ctcactcgat agttaaaatc atagtaagaa attatttcac cagaagactt atagaaaagc 77640
atcccagatg cgtatttttt aaatccagtg aatttaacat ttggcattac tatcgtacaa 77700
tcaccatcat cccagtattc atgaactaat ctatctggtg atgtttccgg aatattttct 77760
ataactttag tgtattttaa atcagcataa actactacag ctctatcaga gttgtttatc 77820
caacagcgtg tgttagattt tttagaccag ttaaagaatg gttctgcata gtatttcatc 77880
ggctgaggcg taaaagtttc ccaatcagac ttttcatctg ctataaatgc catcatatga 77940
taatgcttat cagctagcca ttcacgagga aattcatatt taacagcacc gattaactga 78000
tatttcgctg cagtttcagg gtcattaaca atgttatcac ttaaaaattt aaaattactc 78060
gaagatagag aaactaattt accgtcagtt gacatattcg catatccagg ttgaatacgt 78120
cttctttctt cttcagtgtt gccaaaaact cttttccatg ttttcgtggc atgatttaaa 78180
acatatattc ctttatcggc agaatcaatt atttttgatg ttctaggatt agcatttaat 78240
gtttcaactt caccaataat aagagcaaag actttatcac caatagaatc cattttataa 78300
catactgctt taggatttcc agttatagtc atcgtatcag gttcaaatag actttccgaa 78360
tacgttggag ataatggatc agaatctata ggtgcattac tcgtttttat gtatctaact 78420
ttgtctctgg cgacaacgta aatgtaatca tcggtgcaag taatagcttc tgcaatgcga 78480
tatacattag ctggtaaagt cgcataagtg gcaaaaattt ctacatcaaa tcctagatgt 78540
aattggtcac cgagtttagc gaatgttata ttctgcgaac taaatctgac atcatcagct 78600
gaccatctaa catcagtcga tttgcggcca tagaaaatct tgtcgtatcc tagaacgtat 78660
gttgtgttcg cagattggta atatactgtc ttagataaag gatatcctac acggtcattg 78720
aagagcttta cagctttcca agtttgtcct ttatcattgg atactttaac tacaggttga 78780
taacgctcaa aaaggtataa aatcccttct gattccatca aataaactcg gttaatatcc 78840
ttacatactt gctgaataga accttgtatt tcatgatact cattttcacc aataataaaa 78900
ttacttattg atgaaacatc aacatatgat gggctgaatt gaaacgattc attcatcaat 78960
gcagccatta tagtgtcatt gttaaaattg acatagtcag aattattaag agtaaatttt 79020
tcctgaatga atttattagc taattgcatt tcaatcatgt tttgaaatgt ataagcgttt 79080
gtagcaaaag tttcaaactc ttcagtataa atccaatcag actgctcaaa atcctgcgca 79140
gctgtagcta ctctaataat gtacgatgtc aatggattag cgttatcaaa aaagaagctg 79200
ttatttgcag tatatcctaa gttaatccat ctgtattgat tactcgggag attttccccc 79260
gagtttgttt ttgtctcagc gatttctaca aaatagtaga aattagcacc aacgtcatcc 79320
cagcgtactt gcacctgatt tgcggataac ttggaaattc tgagactagt gactgaaggt 79380
gcttttactg tcattgtgat ataggctcca aatcgatagt taagtattgt ggacgtaaat 79440
cattttcaaa tacaatcagt gaaccatcgc gtgtgaaaat aacatcgtct attggatcag 79500
aatatagctc aatagtctga acctcaaatt tatcggatgt taaattaatt ttagcgatat 79560
tccaataaat catgtcagct ggataattta tttcaccgat aacgtagtat ttgtcgcgtc 79620
catcggaact tgctaattta ttaaaatcat tacctgtata tggctgaatg ttttcatttt 79680
ctgtaacatc acccgaagca aatggaccaa taataacttt accaattcct ttagaatctc 79740
ggtctgttga tactatacga acgtcatata atacatcttc ttctaagcca gtatcaggat 79800
ttacaacctt tcgtccggaa ttaaatgaaa acgtattaga ttccatagaa cgatctttta 79860
tttgattatt gtatttaata cccgcttcag gcgttttata gaagttttgt acttcacgta 79920
ccatctgaat tgtcgctgat gagccaataa tagaatgatc tgcatcatct acatatgtca 79980
acatcttaga tttagcgaaa gatgagttaa aaatttctac atcttcggta taataacgat 80040
caattttatc aattatttga ccttctagcc actgttctga ttcttgcagc ttatttaaag 80100
catatgtgac ttttaaatta gtcttaacaa aaagataatt aggagaaata attgatggtg 80160
taataggagc taaattataa tctttgagat aatttttaat atcttcgcgt tgtacagtag 80220
ttaaatatag tcctgattta ggtttagcag caataaatgc ataaccaggt ttagtagaat 80280
cagtgaaagt ctgaaccgct tgaataatag aaccgaatct ctctgaaacg aatgtatcat 80340
agtcagtcgc agttacgcag cgttgctggg tttcgcgttt aatagtaccc aattcgcgaa 80400
tacgctcaat atcttctgga tcgccgccgc catctgcccc aacaaaatct gggtcatcat 80460
ttggattttc attaatgttg atgacagtta tatttgttaa tgtatctgca tatgaaaatc 80520
cgactgcgcc attcgcatct gcgccgttag tactgatgta ctcaataaca atcgtagagt 80580
tctgggtagg tttaagaccc ccaatataat tagcagtcaa tgctccttct gccgcgttaa 80640
cagaaatctc accttcacca aaataaaatt cagtatttcc atcaatagtt tcacgcatgt 80700
agtaaattgt tgatgtagaa ccagcatgaa ccattgactt tcttgtccag ttaatccatt 80760
ctgctccatc aacgtacagt ttaacttggt ttctatctat atttttgtca taaatgataa 80820
taggtgttaa tttatcataa atgatttcag ttcttactat acgcccttgg gctaatttta 80880
aacgtggaaa atactggtta tttttatcgc gaatagcaat aacatcttcg gtagatacaa 80940
agttgtaagg attaacggaa gtatcttttg catatgctaa aaagcgagta ccacgaggaa 81000
tagtaatgta atttctattc aatgcgtctg tgcaagttaa cataatttca gtttgagcag 81060
ctgattttga agtaggtaaa tatccattat cttgtgccgc ttgaactact gaactacgta 81120
agttagcagt acgcataaag ctttcatata cggcagcatt accaaactgc tgaatgtata 81180
atgtattata agctaaaagg tcacacagaa cgtttaatct tgagccttca aaatcataat 81240
ccaaaaattc attttggcca ttaagccatt catgaggttt tgttttattt cagcaaatgt 81300
acccccgacg aatatctcgg gaatagcatt tgctgttctt gttaattgat aatttacagg 81360
ggtatttgcc attttaaatc ctatttaatg aatactttag atgatgcctg agccacagta 81420
tcaccgcatg atattggatc agccatttga acagctttct ttccagtgac atatacctta 81480
gaagttctag gttgtgtcac tccgccatgt gtttcatatg gctttttaat ttctgtatgt 81540
tctgtaattg gatcacctgc tacgagaaca gcaattcctc cagtgaatac tttactttgt 81600
gtagcattca caactgttgg aggccacgct tcatggccag cagtaacaca cttatcataa 81660
cttaatcctg acattattgc ctctcatata cgtagcttct caatttatta gcccaacgac 81720
tccaatttcc aactatagtt tttgtgtaat ttttaacaag agtttttctt attggagctg 81780
gaggatcggt tggttcagta gtatcagaag atgacctaga attactgcca gaacctccag 81840
attcactttg ttcttggtag tcatatatta atgttacttc gtaagtgaat gtcttctgaa 81900
ggttttgagg agctttccat agatataact gagtattaga atcagttgga aggtcttccc 81960
atgaagcagc agttttaaat tcatcatcta aacgatattt caatgcgtca tttccaaatc 82020
caaatacaga ttcatacgtt ccatataaac gattttcttc tactaaaacc ccaggagttt 82080
cttcgtaact agttatattt atagatacta acgtttcacc tgtttctaat tgagcggtaa 82140
aggtgacgtc gatagaagaa ccttccatgg attctcctaa atcagcgctc attggaagta 82200
tattagccaa ttgttgaatt ctctaatgat gtaaatttat aatcacattt tttcaaagct 82260
tttaaaattg cgttataact tacatccgga aggtcatgtt caattgcttt ttctctaaac 82320
catttgtatt tctgcggatg cggttttccc aaatcctccc aaagtttttt gactttttct 82380
atactaatcc aaggttcaac tgatcttagt tttttatttc tagcatctaa tctcgatttt 82440
cttatcaaag gatcattcca tgattgtttc gttccttcta tttttcctgg atgattgatt 82500
aatttatttc tgtattcatc ggatttccat aaagatttaa cagtattaga aatacgaatt 82560
tttaatgttg ggtcattttc aaaagcagtt ttcatcgcat tactcatttt ctttcgatat 82620
tctggtgatg cgcatctttc tttgtttatt ttagatattt tctctgaaaa ttctttagtt 82680
gacgttgatt tagctaatgc cttcaattga gctttcctat attcaggatt agaccacatt 82740
ctcttcaaat cttcggatga aaaaccatca ccgccggatt ttatattggt acatagaatg 82800
tcagatgatt tatatttcga aatccaatac ctttctctta aattaagaat ttcataagta 82860
gaaacaaatt caattatttc aaaatctatt ttataaccag gtttattgcg tatcttttta 82920
atataatcac cggaacctat atacttgtca ttttctaaat caaaatatct agattcatgt 82980
ttaccaatat aaacacgtac taatcctttc ggattagtaa cggttgtttt atatatgtat 83040
ctaaattgaa cagcgttaga ttttttcata attcacctct gaattattta taaacctacg 83100
tctatacggc taccatcaat tgtgtattga ccagatgaaa tagaactcat agatgccatt 83160
ttttctgtcc aatcaccacc aacgtcccaa tcaactgtcc cagcaacttt ccaagaaaga 83220
tttccattta ctgtattagt ctggtttcct tcaactaaag tggtagcatc tcctttaact 83280
gtaatgtcag cattaccttc aactacaata gtaacattac ctttgactag gatagttcca 83340
ttaccttcaa ccgtcttagt ttcatcgccg cggacaaata ttgtgttgct tccatctatt 83400
tggtgaagac gattatccat gttgtagtaa atttctgatc caccgacgtt agtcttttta 83460
tcgccggcta ccaaaaaatt accgtcagca tttgttatat catacaaatt atcaacagtt 83520
tttctcgttc ttcttcctga tggtgatact tcctcatatg ttccagtcgg atgaactaat 83580
ctgtatcgtt cttgcccagg ggtatcatca aattcctgaa tatgaccgct ttcagtttcc 83640
attgtatgaa catacggata ttcaccttta tatgaagaaa caggttcttt aaataaaatt 83700
ctcgaatcat tcggaatagg agggtcagct ggatcagaag actttgctac agtagcagcc 83760
attgcagaca aagacctagc cggtgttttc acttcaatac cgtatgattc caaattacct 83820
gtaagaataa tcatggtaac acgggatgca cggccttttg tttgttgata ccacaatgaa 83880
tcacgaccag ctttatatgc cttttcccaa tctccggcta acatagcagt taacattgtg 83940
ttaaatttag ctacaccgcc aacacccatc tgaaatgcca tattttctaa cgccatttga 84000
cgagaacgat taactgcttt ccaaactggg ccaactttag aatgtgattt aatgtcacgt 84060
tgcatatcag ccaaatcacg ttcaaataaa gctaccgctt cttccattgt aatagaacct 84120
ggatttccag taatttcacg accaacttgt tttgataaaa ctttattaat ttggttcata 84180
tcacgaactg gctgcttcat gataagatga ccaataccaa ttgtcggata tccttctgta 84240
tcccaataaa cttttagtct taatccttca tcacggcgaa gcatttcagc cattgacata 84300
tttggattat catcagttgg aatctctgat agcggtctat catcaggatt tatcgcagtg 84360
tctagattgc tatcttggat aatattagaa gacgaatcat atcctacttc tccgccttgg 84420
tttaatacgt tagtatcatt tcctagacgt ctaggatact gtccagttgg gtcagaaaat 84480
ccttcaagtc tattaggctt ttcgcgaact attccaccat acgtgccaag gacaattccg 84540
ttagttttcc atttgtctaa aaaatgacca taaactctag ttccttctac cggaccagta 84600
acagagcctc caattccaga cattgctgca gaagttatag gttgaataac tgacatccat 84660
ggtaatttat cagttggaat acccattaca tcaccttgcg ctctttgagg cggatgcaga 84720
ccaaccacac gaacacgaac acgacctaat tttaatgggt ccattctatc ttcaacaaca 84780
ccaacaaacc agttgaggtt attacttatc atttccataa gatttctcca ttatacgtat 84840
aaggtcgttc ataaatgaat tgatgtctga ttttgctatt atttttattt gacgaagttt 84900
ttcattttca agaacagcag cttcatacgt atcgaccgca gcaagtgctc cttcatattg 84960
aggatatttt ctagctttat cgcctttgtc ataccaaaca tatggattat catcgtatga 85020
tattaaatta taaaattttt caccattctc attcacatga tatactattt ggtctccacc 85080
tacatttttg tatttttgta tagatgcttg ataagcagct tcctgtgaag taatccatcc 85140
ataatatgga tcataattat cattacacat caataaaacc caatacaact gcggatttcc 85200
atatatagca tttgctaatt cttccgggcg tggtgaacct ttaatataat aagtacgtaa 85260
gcggtatccc gcaagagcgc gtttgaaata gtctttatag tttctaaaaa tatctgtcat 85320
aggaatagtc ggcgcgtttt tattcaccgt tttggccgca tattcaatcg gatcaaaaaa 85380
tgtaaagagc atgggccctc ctgtttataa atatattatc tatttataag gagaatccaa 85440
tggcatattc tggaaaatgg gttcctaaaa atatatcaaa atatagaggt gaccctaaaa 85500
aaattacgta tagatcaaat tgggaaaaat tcttttttga atggttagat aaaaatccag 85560
aaattattgc atggggtagt gaaacagcag taattcctta tttttgtaat gcagaaggga 85620
aaaaacgtag atacttcatg gatatttgga tgaaagattc ttctggacaa gaatttttta 85680
ttgaaataaa gcctaaaaaa gaaacacaac caccagttaa accagcgcat ctaacaactg 85740
cagcgaagaa aagatttatg aatgaaattt atacatattc cgttaatact gacaaatgga 85800
aagcagctaa agctttagct gaaaagcgtg gaataaaatt tagaattcta acagaagatg 85860
gattacgagc tcttggcttt aagggggcat aatggctatt tttcaaataa ttaatgaaag 85920
cactccccaa gttccaaagg ttaagcaatc attaaacgaa aagaaatgga ttcagatagg 85980
tcttgaatac aaaaaggcca aagcaaaagg aatgacagga aagcaatttg ctgaagaaag 86040
aggaatcaaa tactctacgt ttacttcggc aatgtcaaaa tatgcttcag gaattaaaac 86100
ggctgaaaag attcaaaagc ttgaatcaaa accaatgaat aagctcaata agcaagaaag 86160
acaactgctt atgataaatt cattcaggca aacattacgt gataaaattc gtaatgaagg 86220
cgcagcaatt aataataaaa ccagaaagtg gtttgctgaa actatcaagc aagtaaaagg 86280
acacaaagtt gttcgcccgc agccgggacg aatatatgct tttgcttatg atgctaaaca 86340
caaggaaact cttccttatt gggataaatt tcctttgata atttacctcg gtttaggtaa 86400
acacaattta atgtacggat tgaacttgca ctatattcca cctaaagctc gtcaacagtt 86460
tctagaagag cttttaaagc aatattcaaa tacacctact attactaata aaacgaaatt 86520
aaaaattgat tggagccaag taaaaggatt tagaggtgca gaccaaatga ttaaggcata 86580
tatacctggt aatattatgg gtagccttgt tgaaatcgcc ccgaaagact gggcgaacgt 86640
tgtattaatg ccactccaaa gcttctactc caaaggaaaa cgtttctctg caaacaaagt 86700
ttggagcaat gtacgatgaa ttatgaaaaa atttataatt cactaattga tagggctcgc 86760
aatagagccc ttactggata taaagaaaga catcatatta ttccgaaatg tttaggcggt 86820
agtaatgatg cttctaactt ggttgattta actccagaag agcattatgt tgcacatcag 86880
ctattagtaa aaatacaccc aaattcttta aaattatctt atgcagccat aaaaatgacg 86940
gtttcaacta aatatgttag gagaaataat aaagtttatg gttggttaaa aagaaaacat 87000
gcaaataata tttcaaatac acaaactgga cgaaaatatt ataataatgg taaaagatgt 87060
ataaaattac atgatggaga tataattcct gagggattta ttttaggaag aggatggagt 87120
ccgacacaag gaacaactca ttctagaaaa aatgacacat ttaaaaacaa aaagcttcaa 87180
tctgctttag ctaataaacg gtgggaaaaa gaaaagaaaa taatgttaga taactttgga 87240
gttaacacta ttgatgaagc aaagaaaatt gttcttgatt ttaaatcaac ttgtcatcca 87300
agatattggc gaaagccaac tttagaaaaa tttccattta tgacttctgc tcgtttaaga 87360
agtctaataa attaattcta ttatcttcca ttcttttcta ttgtttgttc taattggaat 87420
tgaatggaag ggacttagac ccattatacc accaacattt ataaagcatt atgaggaata 87480
tatgtcgcaa gcactacaac aaatttttaa ccaagcaaat acaactaact ttgtagtatc 87540
aataccacat agtaatacta catctgcttt tactttaaat gctcagtcag ttcctattcc 87600
aggaattaga atacctgtta ctgataccgt gactgggccg tttggactgg gccgagcaca 87660
gcgtccagga gttacatttg agtacgatcc actcatcgtg agatttatag ttgatgaaga 87720
gcttaagtcg tggataggaa tgtatgaatg gatgctagga actagtaact atcttacagg 87780
cgaaaatact gcccaaaaaa caggtcctga atacattacg ctttacattt tagataatag 87840
taaaactgaa atcgtgatgt caataaattt ttataagcct tgggtttctg acttgtctga 87900
agtagaattt agctacacgg aagattcaga cccagcttta gtatgtacag caacgattcc 87960
ttatacgtat tttcaagtag aaaaagatgg taaaattata gcagaagttt aatgcttcag 88020
tttcatgtgt tataatctta actaaatttg aggagaaaca tatgaaacta atctttttaa 88080
gtggtgtaaa gcgcagtgga aaagatacta ctgcagattt tatcatggaa aattattctg 88140
cagttaaata tcaacttgct ggtcctatta aagatgcatt ggcttatgca tggggtgtat 88200
ttgcagcaaa cactgactat ccttgcttaa ctcgtaaaga gtttgaagga attgactatg 88260
atcgtgagac taatttaaat ctgactaaat cagaagtaat cacgattatg gaacaagcat 88320
tttgctatct taacggtaaa agcccaatta agggtgtgtg tgtttttgag gacgaaggac 88380
aagaatcagt tgattccgta gcatgtaaca agattattga cgttataaat aatattgaag 88440
atcaatggtc agtccgtcgt ctgatgcaag ccctaggtac ggatttgatt gttaataact 88500
tcgaccgcat gtactgggta aaattatttg ctttagatta tcttgataaa tttaactcag 88560
gttatgatta ttatatcgtt cctgatactc gtcaagatca tgaaatggat gcggctaggg 88620
cgatgggtgc tacagtaatt catgtagttc gtcctggtca aaaatccaat gatactcata 88680
ttacagaagc tggattgcca attcgtgatg gcgatttagt aattacaaac gatggttctc 88740
ttgaagaact tttttctaaa attaaaaata cactaaaggt actataatgt ctgaacaaac 88800
tattgaacaa aaactgtctg ctgaaatcgt aactctgaag tctcgtatcc ttgatacgca 88860
ggaccaggcg gctcgtctga tggaagaatc caaaattctg caaggaactt tggctgaaat 88920
tgctcgtgcg gtaggtatta ctggcgatac tatcaaagtt gaagaaatcg tcgaagctgt 88980
caagaatctt actgctgaat ctgctgatga agcaaaagat gaagaataat ggaatttaaa 89040
gacttttcaa cgggtcttta tgtagcagct aagttttcag aattaacact tgatgcgctg 89100
gaagaacttc agcgctcttt acgtgttcct aatccagttc ctagagaaaa aattcattcg 89160
accatatgtt attcaagggt aaatgttccg tatgttccgt caagtggaag ttttgaagta 89220
gcttcttctg gacatttaga agtatggaaa acacaagatg gatcgactct tgtacttgtg 89280
ctagattctg aatatctgcg ctgtcgacac atgtatgcgc gggcactagg tgctacacat 89340
gattttgatg attacacacc gcatataaca ttgtcttata atgttggacc cttatcattt 89400
agcggtgatg tacaaattcc ggtcgtatta gatcgtgaat acaaagagcc tcttaaactc 89460
gattgggcag atgatttaaa ataatttcac aaagttattt acacggggtt ttagttgtga 89520
tactattacc ctatcaaaac aaatgagtga ttggagaata aaatgaaaac atttaaagaa 89580
tttatcaatg aagctacttt taacgaaaaa gtaaaaatta gcaaagctgt caagactttg 89640
attgctgaca tcaattacct atatgatatt gatttaactg actatgtaac agttggtaac 89700
aaacgtaact ttttcgtgtt tgacatctct gaacttgacc agaatcaaat taacaacatt 89760
gagcgttttg ctaatgataa gggtcttcgt catgagtcag cgggttataa aaaatacgca 89820
atttatttaa aatgagttta cttttaaata gggttgtggt actattatct catcaaaatt 89880
aattggaaaa taaaatgaaa acatttaaag aatttatcaa tgaagcggct gcaccaaaga 89940
cattcgttat tcatactcaa gcgggtcttg atgatgagta tgcagaggca attctgaagt 90000
cacttgctaa gaacggcgtt gaagtaatcg cctcggactt taagaaaggg gctcccgaga 90060
tgtttatttc tataactaaa ggatctaaag ctaaaatcaa atcatcattc ggtgttgctc 90120
gtaccgatca aatcgacaat catgacttta aacaaactgg tgttaaacgg cagaacacaa 90180
ttgcatcacg cggaataaaa tagtttataa accgtttact tttcgatggg gtagtgatat 90240
tattacccta tcaactactg aggagaataa aatgaaacgt tgtgaattaa ttcgaaatgt 90300
tgctattgca atttctgctt ccgcttttag tttttcaatg tttgttggat ttatatgcgg 90360
attattgact acagcagaaa atgttttttc acttgtagta gcatttttaa ttggtttaat 90420
tgctatcgtt atggataaaa tttctaaagg ttaataatga ttctttatgc gaaagtatcg 90480
tccgttgaaa atggatataa atatgatcaa gatgcggcta aagccttgat tgatgattat 90540
ggcattttaa catgttttga agttgaaaag gtttacattg accgttcatc ttctcaagtt 90600
aaattagtaa aggaagaccg taaatttaat acagtaaatt ttgatttctt tattgaaaca 90660
gaaaaaggtc ctcttgaata tgatattttc aagaatcctt tgggtcttga atgcatcgta 90720
aacatgtatt atcataaatg gtaaatatgc tttaagaatt atttgttatt attaactcat 90780
atcgcactga ttaataccct ctatcatcaa gggttcttgc ttgagagcct ttgttaataa 90840
ttgggaatta gccaagttgg taaggcactg gattttgatt ccaggatgca aaggttcgag 90900
tcctttattc ccagcgcgag aatggtcaaa ttggtaaagg cacagcactt aaaatgctgc 90960
ggaatgattt ccttgtgggt tcgagtccca cttctcgcac caaatttgcg gatatcgtat 91020
aatggcatta cctcagactt ccaatctgat gatgtgagtt cgattctcat tatccgctcc 91080
aatttaattt actccgtgta gctcagtttg gtagagcgcc tgatttggga tcaggaggtc 91140
caaggttcaa atccttgtat ggagactgga ggcgtggcag agtggtttaa tgcaccggtc 91200
ttgaaaaccg gcagtcgctc cggcgactca taggttcaaa tcctatcgtc tccgtaattt 91260
cgctgattta gctcagtagg tagagcaact cacttgtaat gagaaggtcg gcggttcgat 91320
tccgtcaatc agcatatcaa ggccctgtag ctggaaggtt caagcaagcg actcataatc 91380
gccagatggt ggttcaattc cacccagggc catattttgg gaacataaat actcttagaa 91440
ataggagata tttatgttcc attacattta taaaataaca aataaaatta ataataaaat 91500
ctatataggc gctcattcta ccgaaaattt agatgatgga tatatgggtt ctggtaaatt 91560
attaaaaaga gcccaagata agtatggtat agaaaatttt tctaaagaaa tattagagtt 91620
ctttgacgat aaaacctcta tgtttgagtc agaaaagaat attgtgactg aagagttttt 91680
aaagcgccct gatgtttata atttgaaatt aggtggtgaa ggtggatggg accatataaa 91740
tattcctggg atgctaaacc agaagaaaga cgctagttta aaaggagcta aatcgtttaa 91800
gtcacgtttt aaaaatgata ttttacttca agaaaaatat cgtaaacatg gttcaaatgt 91860
atttaaacgc ttgtggtcaa ctcctgaata cagggaaaaa tttttaaata atagcagatt 91920
tttaaataag catcatactc ctgaaactat taataaaatg aaagaatctc acgccagaaa 91980
taaacatcaa cagggcgaaa agaattccca atttggtatg atgtggattc attcattaga 92040
tgaaaaagtt tctaaacgca ttaagaaaac tgacccaatt ccagaaggat ggtttaaagg 92100
tcgaaaaatg aaattttaaa ttatgtcccg ctggtgtaat ggatagcata cgatccttct 92160
aagtttgcgg tcctggttcg atcccagggc gggataccaa atgagaaacc gggtcgctac 92220
cggtaagtcg tcggactgat gttccctgag taaggaattg cgttaataat ctttgcgttt 92280
attgatgccc tcttacatca cagcagaaac ggcgcaccga attatcgatt cgaggaaata 92340
tctttgccgt aagccgagta gcgtttttga cggaacgttc ggatatggtc gagatatggc 92400
cttttaaaaa tattgagtag cgtcaactac ttaataaccg ggttcgaatc ccggcgtttc 92460
gtacaaacac ttgccttagc aggtggaacc ccgacaaggt tgccgcaagg cttagcccct 92520
accgaaaggt tggggctttt tggtatctag acctttctgg acctctctag gcatcattta 92580
gtttataccc tttataatat attatcctat cttttaattg cccctccctg ccctagaatt 92640
ccctaaaaat ttttaaaaat tttttcacaa aacggtttac atccttgtcc ttccatggta 92700
ctatacaact atcaactact gatacagaaa aacaacttgg agaatgaaat ggataattac 92760
ggcgaactgt tcaacttctt tatgaaatgc gtttcagaag atttcggtcg tacagtgaat 92820
gatattaaag ttatcggtcc tgaccatccg atgtttgaaa cttacgcagt aatgggtaat 92880
gaagatggtc agtggtatac tgtaaaggtt gtgattaaca tgttcactgc tgaaggttat 92940
gttaaactgt cttctaaagt ttaccatgat aacgacgaaa tcgcagaaga atatttcaat 93000
aatatgaaat aagtttacat aggctcatga ttgagatatt atgagcctac aatttgagga 93060
aaaccgttat gtctctttat accgaactga atgaaacttc cgaaaaatct tttgatgata 93120
tcttatcaat aatgcaaaag caggtattag aagagcttag tgaagccgca agcaatgggt 93180
acaaagcttg tcgagttcaa agcccacatc gccgcatgta tgaacgccct cttattaatt 93240
ggctagaaag cgaaggtctt acggttaaga tttgccctgc taaatttgat gtcccacgta 93300
ttcttaatat ttactgggat aaaccggttg agaaaagtga cacttgggtt gttaatgtaa 93360
aaacatgcga taatggatgc tcacttgagg tgtctgctgt aattaaaggc actcatggtg 93420
aaaaatcgtg gggttggcct ggtaaagata aagaaatcgt gttaagtgta aaagctacta 93480
atattatagt aatcctatag ctaaaagcat tatcactgcc gctgttgaag aagctgaacg 93540
aatttgtaaa attaaaaata gtttacatct cttaagtagc atgatataat tcttctgcag 93600
attttaattt ctaatcaacc taaggaaata ctatgaacac actgaagaaa attgttgagt 93660
ttattcgcac taaacttggt tctgctatgg ctaaaaatct atctgtcgaa gaacagtata 93720
ctgctgcagc agcaaaattg cttgataaaa ttaaagatct aaaaactgct tctgttaaat 93780
ctattaatga agaaaagcgt attcgtgaac ttgttatcga aaagaatcga caggccgaat 93840
caaaagagcg tgaaattcgt aaacttcttt ccgaaggtca agatgtaaca atgcatgcta 93900
aactcggttt actatatcgt cgaacggctg agcagttgac tactaaggct gatggttatg 93960
ctgaaatgcg aattgaaatc gccaagaaag tagttgagtt agatgatgct cgtcaagaac 94020
ttgcagttaa attggaatat atccgtgaaa ctcgtgcggc aaatgccctt ggaattagta 94080
ctgccgatga tgtagttgaa attgcggcac tgactaaggt tgatattgaa gatacccttg 94140
ctcgagttga aacctttaac ggtaatattt ctggggttga aactacctct gccgatgttc 94200
aggaatatat taattctctg aaataatgat aaggggcttc ggcccctatt acttggagta 94260
aataggaatg aaaatgcaaa gtgatttcaa ttcaatgttt gaagaattcc aaagacaagt 94320
tgatgttcca gaccaattac taaatgctct taaacgtatg gcagaaggac gtaattatta 94380
ttggggttct tcatatgaaa ctaatgaaag tctttctgga agattttcca gaggtaaaaa 94440
gtctttaata cgtcctggaa tacttattaa cagtattgaa tcaatttatt cattgacatg 94500
cgattttgat gttgaattta ctgatttcat ttctcctgaa tggacagttt gttatttaaa 94560
cgacgatttt gattatctcg gtgtttatag tttaagtgac gcatggttta aacgtaactt 94620
acaaaagtca aatttattct atattgatac tacagtaaaa tttcagggaa agaaatattt 94680
ctttactctt atagttgatt ctgaaacgaa gcatgaaaat aaacgtattc ttagtaaaag 94740
aaatatcttg aatattgttg atgatctttt tgataaatta gtggaaaatc ctaattttga 94800
aagtgattta ttactagaaa aatttgttaa ggaatgtaga gaatatgtca aaaccatcac 94860
tataccttcc aagtaaaccg ttgaagtatg aattaaagcg tcagataatt tctactgatg 94920
tattaatagg tcctgttata cttattctat tgattattgg aggtgtttta gatgttatga 94980
ctgatattga ttctggcgaa atacttgtgt taatgctaat tcttccatta atagttccac 95040
ttttattagt acccgtaaat tgggtaggat actggtatca aggaagacat tatcgtaaac 95100
gcgtacgtga ttggaaagcc cagtgcaaaa agattaaaaa ggaacaccag attaaacttg 95160
ctgcgcatga atttgatgaa attatgaaat ttgttaagga atcacgatgc aaaagccaaa 95220
actaaataaa gtcaaatatt cgtttcctga gtcattttta atttttgctg tggcgttggc 95280
tgcagctctt gcgggtagtc tttttggatt gttaattgac tgtcttattt taaacatcga 95340
tggcacagta aatataatag aagtttggag tgaacttcgc tatactaaaa ttatttcatt 95400
attttcattc ttttgtatca ttctatattt tcattatgat aattttaaaa taaattggca 95460
aagaaaaaag gattacaaaa tacaattaaa agaatataat agctacatgt cttatattga 95520
aaatgaatca atgaaagagt ttgtgattga ttgcaggaaa ttaaaatgaa aacattatca 95580
gctggtatta tctttatgac agaagataaa gatttattta tgggtcgggt tactggttct 95640
cgtaagcctg gaatgatggc acatcgctgg gatattctag aaaattctga tttaaacgca 95700
ctagatgcag cacgaagaga atgtttagaa gagactggtt ttagcaatta taatccagac 95760
cttctagaag acctaggtgt atttaaatat tctagtaata aagacttaca gttgttttat 95820
tatacgattc cagtagagca tgagatgttt agaaattgcc attgcgagtc ttattttgaa 95880
aataaagatg gtgttatgat tccagagatg gatacttttg ctcttattcc tcgtactcag 95940
tggcaatatg tgatgggtcc ttcactttac cgaataatga acagcctctt ttaatttata 96000
aataccttct ataaatactt aggaggtatt atgaatatat ttgaaatgtt acgtatagat 96060
gaaggtctta gacttaaaat ctataaagac accgaaggct attacactat tggcattggt 96120
catttgctta ctaaaagtcc atcactaagc gttgctaaat ctgaattaga taaagctatt 96180
gggcgtaatt gcaatggtgt aattacaaaa gacgaggctg aaaaactctt taatcaggat 96240
gtcgatgctg ctgttcgcgg aattctgaga aatgctaaat taaaaccagt ttatgattct 96300
cttgatgctg ttcgccgctg tgcattaatt aatatggttt ttcaaatggg agaaaccggc 96360
gtggcaggat ttactaattc tctgcgcatg ctccaacaga agcgttggga tgaagcagca 96420
gtaaatctag cccaatctaa atggtatcgt cagacaccta atcgcgcgaa acgcgtaatc 96480
tcaacattta aaacaggaac ttggaaagcg tatatatgaa aacatatagt gaatttttat 96540
cagaatctat tcttaacgaa gctactgaca catttgcaac taagctaggt gcagctttgg 96600
ttgaagccga aagtctatta gcacgtattt ctgaacttgc tagtaagata gatactcgca 96660
aatttgaacg taccagcgat atcgttaagc ttgaagcctt gttgcgtatg tgcgataaac 96720
cagaagaaat cgctaagaac ggctcgctaa tgaaacaacg tcttgaaaaa tatatttcag 96780
gcgcttcaga aaaatagtgt ttacttcctc caaggacttt gatagtatat tcacaattac 96840
ttggagtggt aaatacagaa atggacaatt catgcgccac ggaatggccc catttaattt 96900
aaacttacta tcctaggatt taaaatgaaa acatttaaag aatttatcac tgaagcaaaa 96960
gccccgaagg tttttcaaat ttgttcacaa ggaaatttag acaaagaata cgttgacgcc 97020
atcgtagcaa gcattgtcaa ccaaggcgtg caagtagatg cagttgaatt taccaaaggc 97080
cctaccttta atatcgttgt atctaagggt tctttggcta aaattaaaaa ggcctggggt 97140
gttatgagag cttaccaagt agatgattct gctcccgggc cgaaagtacg aatgaatacc 97200
cttaagggag gccgtgaata cgtttaggcc tattgtctat acttattaga atattatacg 97260
gactaccatg tgccacggaa tggcccaacc taaaagagaa actaaatgag aacattttta 97320
actggtcctt atctatccct gatgaatgct tttacacacc attctgatgc tagagtagaa 97380
gaaatttgta aaaacgatta tatcccacca tttgaagacg tactcaagca gtattgcaca 97440
cttcgactag atggtggacg tcaatccggt aaatcaactg cagtaactaa ttttgccgct 97500
aattggttgt atgacggtgg aacggttatt gttctttcta atacttcagc ttacgctaaa 97560
atttccgcag ataatattaa aaaggaattt tcgcgttatt ctaatgatga tatacgtttt 97620
cgtttattta ctgattctgt gcgcagtttt attggtaata aaggaagcaa gttcagaggt 97680
ttatcgcttt cgcgaatttt gtatataatt gatgagcctg tcaaatctcc tgatatggat 97740
aagatttata gtgtccatat tgacactgta cactgctgct gtaatattaa atgttgcatt 97800
ggtggtatta ctcgtccaca gtttttcgta atcggaatgc aatgatgaca gatacgcaac 97860
ttttcgaata tctttatttt tcgccaaaaa ctattaaaaa taaattggtg aatcattttg 97920
aaattttggc aaataacaat gtcttgagcg aattttatcc taagcaatac aaattacaaa 97980
aaggcgtatt caaaggatgc agagttttgt gcactgctcc taatgcaaga ttaatgaata 98040
aaattccata ttttgccatg gaatttattg atggaccttt taaaggacta attacccaaa 98100
gtttaatggc atatgattct gagccatttt taattaaaga gcaatcttgg ataaatttat 98160
tttctaattg agaggttata tgaaagcata tcaaattctt gaaggcacgc ataaaggtac 98220
tatttatttt gaagacggta ttcaagcacg aattattgtc tctaaaactt ttaaagagga 98280
ctcttttgta gacccagaaa ttttctatgg tttgcatgcc cgtgaaattg aaattgaaac 98340
acaacctaca gttaaaatcg agggtggtca acacctgaac gttaacgttc tgcgtcgtga 98400
aactctggaa gatgcagtta agcatccgga aaaatatccg cagctgacca tccgtgtatc 98460
aggttatgca gttcgcttta actctctgac tccggaacag cagcgcgacg ttatcgctcg 98520
tacctttact gagagcctgt aatggcaaag ataattattg aaggttctga agatgtgcta 98580
aatgctttcg ccgagtggtt tagtaattca ggcgaacagc aatttaatga agcgtggaac 98640
atgggtgata ttaatggaat ttatcctacg acagaaattt ctgttcaagg atatggcatt 98700
catgagccta ttcgtttagt tgaatatgat ttgggaacag gtgaggaagt caaatatgat 98760
tgaagacatt aaaggttata agccacatac tgacgataaa atcagtaaag tgaatgctat 98820
caaagacgct gaagttcgtt taggacttat ctttgatgct ttatatgatg aattctggga 98880
agcgctagat aattgtgaag actgtgaatt cgcgaagaat tatgctgaaa gtctcgatca 98940
gttaactatt gctaaaacga aactcaaaga agccagtatg tgggcttgtc gtgctgtgtt 99000
ccaaccagag gaaaaatatt aatggctcaa ttaagcgcag ggtttggtta tgagtattat 99060
actgcccctc gtcgtgtatc tgttgctcct aagaaaattc aaagtcttga tgacttccag 99120
gaagtagtcc gtaacgcttt ccaggactat gcacgctatc ttaaagaaga ttcacaggac 99180
tgtctcgaag aagatgaaat tgcttactat gagcagcgtc ttgaacaact taaaaaccta 99240
catgaggttc gtgcagaagt tacaaagtct atgaataaat tgattagatt taaagaataa 99300
ttgtttactt ttcctcttga ctgtggtata atttttctat cagttaagag gagaataaca 99360
tgactatcaa cacagaagtt tttatccgtc gaaataagct ccgtcgtcac tttgagtcgg 99420
agtttcgtca aattaacaat gagattcgtg aggcatcaaa agcagcaggg gtctcatcgt 99480
ttcatctaaa atattctcag catcttcttg atcgtgcaat tcaacgggag attgatgaga 99540
catatgtttt tgaattattc cataaaataa aagaccatgt tttagaagtt aatgaattcc 99600
tgagtatgcc tccacgccct gacattgatg aggattttat tgatggggtt gaatatcgtc 99660
ctgggcgttt agaaatcaca gatggaaatc tttggcttgg atttacagtt tgtaaaccta 99720
atgcgaagtt caaagacccg tcgcttcaat gcaggatggc aattatcaac agtcgtcgtt 99780
tacctggaaa ggcttctaaa gcagtaatta aaactcaatg aggtaagcat gagaaaagca 99840
ctactcgctg gtctattggc catttctatg atggcacata gctccgagca tactttcagt 99900
aatgtccaac tcgataacat gcgttacgcg tatcaattcg gggaacaatt ttctaaggat 99960
ggaaaatata aaacacacaa aaatatccac aagagcggat taggccatat aatggctgct 100020
attttatggc aagaaagctc tgccggagtt aatttaaaat ctaaaccaaa acatcatgcc 100080
tatggaatgt tccaaaatta tttgccgacc atgcgagcaa gagttaagga acttggttat 100140
aatatgaccg atgccgaaat aaaaagaatg ttgaataaac ggtccaattc agcttcctgg 100200
gcgtacattg aactttctta ttggttaaat atacataagg gtgatataag aaaggcaata 100260
tcctcttata attcgggatg gaatgttaaa gcaggttcta aatatgcttc tgaagtccta 100320
gaaaaggcta actaccttaa aaataataaa cttttggaaa tagtaaatga ctaaaatttt 100380
ggttttatgt gtaggattaa tttcattttc tgcgttagca aatacatcat atactgaaat 100440
tagagagtat gcaaaccgta ctgccgcgga ttattgtggg aaaaataaag catgccaagc 100500
tgaatttgca cagaaattaa tatatgcata taaagacgga gaaagagata aatcaagcag 100560
atataaaaat gatactttat taaaacgata tgctaaaaag tggaatactt tagaatgttc 100620
agttgcggag gagaaagata aagccgcttg tcattcaatg gttgaccgtt tggtagattc 100680
ttataatcga ggattgagta ctagatgatt gtaaaatata tcaagggcga tattgtcgcc 100740
ctatttcttc aaggaaatat tattgcgcac gggtgcaatt gttttcatac tatgggttca 100800
ggtgtagcgg gtcaattagc aagggcctat cctaaaattt tagaaataga taaaaccact 100860
accgagtacg gttctcgtga taaattaggc gatatgtcta ttgtttttaa acatagtcct 100920
acgggatttg gtatatgcta taacctgtat acgcaatacg aaccgggtcc taatcttgat 100980
tatggtgctt tagtaaattg catgatagaa ttaaatctac aggcagaaac ccttttgttt 101040
aaaccagtaa tttacattcc acgcataggt tgtggtattg ctggcggtga ttgggataag 101100
gtttctaaat taatcgacat gtttactcct gatattgatt taatagtggt ggattatgaa 101160
agcacattac ccacatccgt ttgaccctaa aaataaagtg gaaattattc gtcagtggga 101220
acgcatttgc cgtactaaat gcccaattaa tagtctacat gatgtagata aagactacat 101280
tggaacattc gttgaatata cctttattga taagaaaggt cgtaaacagc atgtagaaga 101340
atattgctta aaggttacat ggttatgagt ctgagtaaag aacaaaaaga taaattgttt 101400
gagcttatcc atgaacttct agatgagcat acagaagcaa acacctttta tgatgaatac 101460
ggcccgctat ctcccgatca acaagaagaa tttgctgatc ggtttgataa gaaagaaaat 101520
gaattaatag cttatgtgaa tacgctttaa gaaggtgata tggcgagttt aatttttact 101580
tatgcagcaa tgaatgctgg aaaatctgct tctcttttga ctgctgcgca taattataaa 101640
gaacgcggaa tgggtgtatt agttcttaag cctgctattg atactcgcga ttctgtttgt 101700
gaagtcgttt ctcgcattgg aattaagcag gaagcgaata ttattacgga tgatatggat 101760
atttttgagt tctataaatg ggctgaagca caaaaagata ttcattgtgt atttgtagat 101820
gaagctcagt ttttaaaaac tgaacaggtg catcaattaa gccgaattgt tgatacatat 101880
aatgttcctg ttatggctta tggtctaagg actgatttcg ctggaaaatt atttgaaggt 101940
tctaaagaac ttttggcgat tgcagataaa cttattgaac taaaggcggt ttgtcattgc 102000
ggtaaaaaag cgattatgac agctcgatta atggaagatg gaacaccagt taaagaaggt 102060
aatcaaatct gtattggtga tgaaatttat gtttctttgt gtagaaaaca ttggaatgaa 102120
ttaactaaaa agctcggtta gtgcaaaagt tataaatagg tttatctaac taaaggggta 102180
tatatgctac aattaactga aaagcaactt cgcaatctta ctgtgcttca attagatgaa 102240
attcgtaggg aagttggaaa tatcatttca gctttgcgtc gagaagtatc gctcaaccaa 102300
tctccggcag actatactaa attgcgaaat tttgaaaaat accttgataa agttaaggcc 102360
gtgcatcggc ataaagtaaa tacaggacaa aaatgatagg aggcctttat ggccttaaaa 102420
gcagcggcac tattcgccat gctaggatta gcgtttgctt tatctccacc aattgaagcg 102480
aatgtcgatc ctcattttga taaatttatg gaatctggta ttaggcacgt ttatacactt 102540
tttgaaaata aaagcgtaga atcgtctgaa caattctata gttttatgag aacgacctat 102600
aaaaatgacc cgtgctcttc tgattttgaa tgcatagagc gaggcgcgga gatggcacaa 102660
tcatacgcta gaattatgaa cattaaattg gagactgaat gaaattcagc gacttttcac 102720
aaagtggaaa accttcaaag gcagatgaat acttaggttt attaatggct gcgcaagctt 102780
attttcattc tgcgcatttt gaaactaaaa gttatgctag acacaaagca tacgatttta 102840
ttttctctga gttgccagat ttgattgata aatttggtga gcagtatttg gggtattctg 102900
gcagaaaata cacgccttca attccagatg ctagtaaact tcctaccgac acaattaaaa 102960
tgattgatcg tatactagac caatctaaca gcatttacaa agaaatgcct ccagccattc 103020
aaagcacgat agatgatatt actggaatgt tttaccagag taagtatctt ctttccctcg 103080
aataacatta gtctccttcg ggagactttt ttcattttac cggtttactt tccatttgag 103140
ctgtgatact atacaaccat cggataaaga ggagaacatc atgaaaattg aagcacttaa 103200
tcaagaagga aatatctacg ttatcattaa tggtgatttt ttcgtcgaca tggatgaagt 103260
tactagtgaa gaacttgtag aacttcttaa gaaacgctat agtatgtgtg atgaagctgc 103320
aactcatatg gcgtgtgcaa tattctctct ttcatatgtg gtggaataat gattagtatc 103380
gaacaagcag ataaaattaa agaattggta gctttaattc gcaaagcaga tgaggaacgc 103440
attaactttg ccttatcagg tattgaagaa tttgaagcta aagttgataa tgctgtagaa 103500
gctttagata tgtttcttga tgaaattatc gatcacaata cgagagttta agtatgctga 103560
cacgcgaaca gtttgaaaaa atcattaaat tagcacgtga tgttgaaata gattcatatc 103620
aattagcagt tgagcattgt gaaggatatt catacgacgg tatagaagca gctaaaaagg 103680
atttggataa atctaaagct aagttagttc aatatcttga aatgattagg tggaataatg 103740
aaaactgtag ttaagtctta ttttggtagt catctttatg gaacttctac tccagaatct 103800
gatgtagatt ttaaagaaat ctttgttcct cctgctcgtg atattcttat cggaaatgtt 103860
aaagagcata tgagtaaaaa cactaacaac acatcatcta aaaacaccaa agatgatatt 103920
gaccatgaac tatacagtct taaatatttc tttaaattag cagcagatgg tgaaactgta 103980
gcattggata tgctccacac tccacctgaa ctggtagtta aatctgattt gcctgatgta 104040
tggaagttta ttcaagacaa tcgttctcgt ttttatacga ctaacatgaa atcctattta 104100
ggatatgttc gcaagcaagc ttctaaatac ggtgttaagg gttctcgttt ggccgcatta 104160
cgtgatgtat tgaaagtagt taatcaaatc cccgatcagt gggttgatta tcaagaagga 104220
atccctgata gacttcgtcg tactaaggta gaagatatca aacacagact ccctgaaaac 104280
gagttctgtg aatggatatt ccataatcat gagaaaacag gcccacagac gttttacaca 104340
gtgttgggtc gtaaatatca gacaacgctt tctcttattg agcttaagca gtcactgaac 104400
aaattagatg ctgaatacgg tgaacgtgct cgtaaggctg aagcgaatga gggcatcgac 104460
tggaaagctc tgagtcatgc ttgtcgtggt ggactccaac tattggaaat ttacaaaact 104520
ggtgacttag tctatccact tcaagacgct ccatttattc tcgacgtgaa gttgggtaaa 104580
catccattta aaaccgttca agagtttttg gaagatgtgg tcgatcaagt agaagcagca 104640
tccattgaag cttctaagaa cggtatgcct aaaacagtag acatgagttt ctgggatgac 104700
ttccttgaga aggtctatct tgaaaaccac cgaagttatt ataaatgata gggagccttc 104760
gggctccctt tttttatttc aaaaattttt tcacaaagtg gtttacaagc ataaagcttt 104820
atggtactat acaactatca aaacaaacac ttaaacggaa aaacaaaatg aaaattacac 104880
caattgaagt aaaaaagttg attgacacag aagaaatttc agagtgtttt gaaagtttct 104940
tagaagatgc aactgaagat aatgcagttt atctcgctca gaaaattatc gaaacttatt 105000
tggagaagaa tcaatgacag tttacgtaga tgttttaatg aatcatggat ggaaacttcg 105060
cggtcatcca actaaaaatt gtcatatgtt cactgatgga gatattgaag agcttcacga 105120
aatggcagaa gcaataggaa tgaaacgttc ttggtttcaa gataaacgca ttaaacatta 105180
tgacttacac gctcggcgac gccaaaaagc tgtagaactt ggagctgtag aagtatctcg 105240
tcgcgaagca gtaaaaattt ggcaaacatt aaaataaatt gtttacagca gggtagtagt 105300
gtgatactat taccctatca aaacaaatgt aaaattggag aataaaatga aaactgtaac 105360
tatcaataag ggtatctact tcggtaaaga aatctctgga acttttgagc tcttaggcga 105420
atggttccca gataatgctc cggtagatgc acaaggagat ggtaaagttt ttgttgaaat 105480
tgacggtaaa cgtcgcggtg tttgggttta caaatcagat atttcatatg atggtgtaaa 105540
agttgaagaa gttaaagaat catatgaaga tatgaaaacc cgcattaata aaagatttaa 105600
tgttatggga atgatgacga acggtattat taatggaaat attcgttcat taattatctc 105660
tggcgcagca ggtattggta aaacgtattc tttagataaa gctttaaata aagcaaatga 105720
taatggatac attgaatata aaagcattaa tggtaaaatc tctggtattg gtctttatga 105780
gcaactttgg aataatcgtg aagagaattc tgtccttttg attgatgatg tggatgtttt 105840
ctctgatatg gacattctta atcttctaaa agccgctctg gacactggag agacccgtaa 105900
agtctgctgg agcactgcat cttcttactt agaagaaaaa ggcattgacc gtgagtttga 105960
atttaaagga acgattgttt ttatcacaaa cgttgacatt gaccgcgaat tagaccgtgg 106020
tactaaactt gctccacatt tacaagcatt agtgtcccgc tcagtttatt tagatttggg 106080
tgttcacacc aatgaagaaa ttatggtcag ggttgaagat gttattcttt caactgacat 106140
gatgcaaaag cgcggtcttt ctgatgaaga aacttataaa gcattatcat ggatgaaagt 106200
caatgttaat cgtttacgca atgtttcact gcgtactgct ctttatcttg ctgactttat 106260
tatgaccgac aaaaacggtt gggaagaaat tgctgaggtt actcttctga aataattcat 106320
aagaggactt ctatgacaaa aaggcagttc agaaatagat tatatggact gccattaaaa 106380
agatgactag aattaaactg gtgaatggag gtagtgatgt tatactcaaa ggctcgtgaa 106440
atttacgaaa ctaaaattaa agaagcagta tttcagttcg caacaacaat gcgatggaca 106500
aatgactggg agtattcaaa aaatcataag aagcccatgg tgacaagaaa ggctcatatg 106560
ttagtgttaa tagaccgtga gcagattaaa gcccgagaag ccctccagaa tcataaaaag 106620
gctgcctttg aatggtttat ggataacact gctcctgaga ctaagaaagc agtgagcgcg 106680
tggttcagtg gaaaaaattg tgaaagaagt ttcttttagt tgtttacaag accgttcctc 106740
tgtggtacta tacaactatc aactacggag gaacagaaaa tgaacgctaa agatattttc 106800
aacttggtaa attacaacga tggtaaattt aaatctgaag cacaaagcaa gttctttaac 106860
gacatctcaa tcggaggtga aatcactgtt gatggaggac aaatttacaa atcccgctgg 106920
aattggatcg ttattattga tgagatcggt attgtagaaa tttacaagaa tacaaataaa 106980
aatcgtacat tacactggtc tcgtgatact aacgaacagt acaaaaagga taaagcatct 107040
aaattatctc gtgtaactca agaagatatt gagttcatca agaaagatat tttaatgtat 107100
gataacttaa ttgctgaaga gcaagctgtt attgataaat ttgatgagat taaagcttct 107160
cgtgaaattc ctgattttat gaaagaatca gtaaatgaac gatacactct catttcagag 107220
cgtattgaaa cttacaaaaa gcaaagagct gaacgccaaa atactcttcg gaagtttgaa 107280
gaacggttaa agacggtact cgcataaccg ctttatatca aggatggtat aatggttcta 107340
agccctttta attgagatta ttatgaaaca gttgataatt aaaagattga atttattgat 107400
atgttgttta tgtgtagtag ttgcatatgg ttattacgca attaatgatt atatgcatta 107460
taaagattat gatgttactg tagttaatac cattacagga acacaaggaa aagggtctag 107520
tttatcgttt attgccgtat atgaactcaa agacggttat agatttagtg aatatatttc 107580
cccggagatg tattcttcaa tagaaaaagg tgataatatt actgtaagtt tacgtccttt 107640
cgacgtaaaa cagacactgt ttgataatat tgtttggttc tttggaatgg cattagttca 107700
atctatatgt ggtgcttata tagtctgttc catcttattc tgtatattta gtaaaattga 107760
aattgagtga ggaaaatatg tcagtagtaa ttaataatgt caatgcagta attaaatctt 107820
tagttaataa aaaaaatgat gaatgaatgg actgtatttc gtcgtggaga gccagataaa 107880
ttttttcata gatttaactc aactttggat ttgaatgtta tcgacagaga tgttcatgca 107940
gaaattttag ataagtttaa agttgatatt ggatttggat tagaaaaaca tttacagcga 108000
acaaatgggt ctggaatgag tttatctaat cgcattatga aagcccttaa taaaattgga 108060
gcgttgtctc gtattaatgc aagtgaaatt cttcgtaatt acaataaagg atatgacctt 108120
tatggtcgac tgatgccaaa attatcattc gatcaaatga tcgcagattt gtgggaaaat 108180
caacgacgac tattagcatt aggcgctcga ttagctaaag gtctagataa acaaatgatt 108240
tttaagacca ataatacaga agaccttaaa tgctttaaat ttagtattcg tggcgatgat 108300
tattacatca gagctcactc tacagattat gttaatatgg ggcatcatct ctgtttagct 108360
tttgaagttt taaaagaagc tggaacatta gaatatacgt ctggtgctaa atgcccgatt 108420
ggttcaaatt gtattttgat ttatcgcccg gatgaatcca gttcaactaa attgcctacg 108480
aaacctgtac cagttcgtag taatgaaaaa cattctgaac aaattgatta ttttaataaa 108540
cagattgaag agctgaatat ttctattcaa caatatgatg atgaaatttt cagactatct 108600
ggattgagta gtaaagctaa atctgagcgt gaaaagttaa ttaaaattgt tgatttactt 108660
aaatcttaag gaacaccatg aaaactcgtt ctcaaattga agatatggtt cgtactgcca 108720
gcgatactcg taatgttatg acatttttgt gtgaaaataa tttagaccct gataaagtta 108780
atcgtgctat tcatcacttt aaatatctaa atagcagtga atgggtgagt aattttagta 108840
aagcgggggt atattacaca aatgacggct cgtgagcagc tcaccgattt ctgtaaaact 108900
attgattata aaaatcctct atttgttcaa ggcgttggtc aaagtaaggt cgatttatca 108960
tctggatttt tcaatccaaa tcattatcgt attgaatgga gatttattgc tctgttccgt 109020
agacaattaa agcaaatttt atcaactgcg agtcgattaa aaggttctga tattaactta 109080
aagaatctga aatttgatgg ttatactctt cagatggaag taagaccatt aaaagaaaat 109140
aatagaactg cacgaattag ctttaaacct aatacaaaaa attctctttc aatttgcgaa 109200
tgccttaaat cgcagttgac agaagcattt aagtatatgg atgttgttgc cgctgttcag 109260
tctaagattt tacctcgttt tgaacgattt aaattagaca caacaacgta tgaacttgat 109320
atgatcgttt catttaaata tgatttttta agaaaggacg aagttacgca agagaaaaag 109380
caagaagtgc aagataactt aaatttatcc aattacttat caaacgatcc taaattttgg 109440
atgtatagct caagcaatat agatgcatgt aaacttaata aagtgagttt tcttcctact 109500
gaaaattcaa attttaaacc tgtagaaaaa tggcacgctg acgcgattga gaagtctctt 109560
aaggcagtag atgatgaact cgttaaagcg accaatgaag tgctagaagc tgaaaaggcg 109620
ttagaacaag ctcagttaag ggttcaaaat ctgacaaagc aacgttctaa actgaacaat 109680
gcactaaatg cactgaacta gtttactttg ccacaaggat gtggtataat gttcttactt 109740
tctactgagg agattaatat gactcgtaac gaatatatca aatcattcaa tagcgttatt 109800
gatgataaag ctataccgtt gtttggccaa aatatcgttc tttctattat caatcaatgg 109860
ctcaatagtg ttgatgcaag tattgtttct tctactaaat ttattcatga aattcgtaaa 109920
atttctagcc gtgtagataa agatgttatc aagaaaacct ttaaagagtc tcgtcttctt 109980
tcatatttgg ttaatcggga tattcttggt aattttggga aagaaattaa acgaaccaaa 110040
gatgtagtag gatataattg gttcggtgat gttaattctt atcatcttaa taataaagaa 110100
gaccctgaga atatttttac tcgtcgttgg attagtaatt tcagactttt caaaggacag 110160
attctaaaat cagcttctaa attatgttat ggcgattatc gtcaaattca tcctttggct 110220
tctgatatga ttatcataaa agaatatgaa cttgataaaa ataaagtagc tatttttgta 110280
aattatggat tttttacacc agaaactaac caaaagaaca ttaataaatt tttctcaatt 110340
gctagcacta taactcgtca attagagacc gcattacttt gtatggaaac agtagaaaat 110400
attcatacat atccttttaa gaatatatgc ggttgggaag gatataaact cgtaattagc 110460
cttcgtgaag tgaaatgtgc ttattcaccg actgataaag aaatttgcca acaaaaatgt 110520
gatgaaattg tgaatactcc taaagaagaa actacccttg aggaactaat ggataatctt 110580
gatgattcgc ctgaaccggt agaaattcgt ccagaagtta ttgcattaga aaaagcttat 110640
aaggaagctc tagaaatttc taataaagcg cagaatgaat atgagcaagc taaaaggatt 110700
tgggaagaat ctgttaatcg cttggatcgt cttgaacaag ctttacagtt aattaagtaa 110760
tttaaagcca aggatggctc ggagtataaa tcattaacca agtgagaaga acatgaaaac 110820
tcgtaaacat tatattgatt attttgacag tcttattact aaacaccgta attatcagat 110880
cgggcacaga gcagtaatca ataatattct tcgtgatttc cttcaatatg ttggccagga 110940
aaatcatatc tgtaaagata ctcaaaacgc ttattctcat tcattaggca atttgcttga 111000
atggtttaaa cgttctcgta tgttatcttc tactgtagct cgtgataaca ttgaaaactt 111060
tatgaagccg agctttatta aatctgagac atctataact gatttggttg aatttactat 111120
tgttaacgat gttaaaaaga cccatttggc tgattggtta tctaccattc ctgaaactaa 111180
atttgctgat aaatttgctt gtcaattcaa tgaccaagtg aatatgcttt ttaagcatgc 111240
tcgcaaacta tttaccgcgg gcgatgaccg tacaaataca gttcatgtta aggactgggt 111300
tattgctgat gaagtaacac acaagccagg tggttcatca gtattaatta atatccaggt 111360
tccttattat tactcacgta atctcggcac catgacagct agagaaatta ataagcacaa 111420
caaaactatt cgttcgttgt cttataaact ccgcatgatg ctaaaaatta tggacgtagt 111480
ggaaatgtat gacgaaaccg aagataatgg ttcaatgctg tacagttcac gcattctaat 111540
taaactgaag aaccctaata catataagcc agttgcaaaa gaacctaaag tagaaaaggt 111600
tgataacctg agtgaagaac gtgaatatct caaatctcga ttggttgaag ttgaagccca 111660
gattgccgaa cacaccaaac tgttaaaagc tcttaatgca aaagcaaatg gtttacgtaa 111720
tgctattgag gtattgaaat gaaaaagcgc ttattagaag atattgcagc ttcaagtaat 111780
tccagtctaa ttaaaattat tatggctggt gaagaagacg atctagaaat gcgtggaaag 111840
attcatggtt gtgacgatct agactttaaa cctcctgctt gggatgccat tatggttatg 111900
gttgaacgtc gcgaaagggc ttctaaaaac gttcctaatt gtcctgaatg cggtactgaa 111960
caggtacaat tagttcattg gcagactagt aatcttcgtt ataaatgtcg ccattgtaaa 112020
caccgatttg accgagaaga aaatgaccaa gcgtaaagaa tatatggagg ctgctgaaaa 112080
ggcagtccgt gaattagcaa tagcttatta taatgaacac ggtaaatttc ctgatagata 112140
cagcgtgctt aaatctgctt taactcgttc atataaaaat atgctatcag aagtaagtga 112200
tattatatac aaacataaag aacaaacggg ccaaagtctt gattacgacg agacttttaa 112260
acaagtacta ggaattaagg aataatatgt ttaaagtata tggttatgat agcaacattc 112320
ataaatgcgt gtattgcgat aatgcaaaac gtcttttgac cgtgaagaaa cagccgtttg 112380
aatttatcaa cattatgccg gaaaaaggtg tttttgatga tgagaaaatc gctgagcttc 112440
tgactaaact aggtcgtgat actcaaatcg gcttgacaat gcctcaggta tttgctcctg 112500
atggaagtca tgttggtgga tttgaccaat tgcgggaata ctttaaatga tgctcgaagg 112560
aactgactat attcacgatt accgcggaag cgcggtatat gtaggtgatg aagttgcagt 112620
ttactatggg tatggaactt tgatgacagc caaggttatt caaattaaaa ataatcgtgc 112680
taaacttgaa gtttattatt ctaatggtga aaagtctatt tctaagtgga aatacggcga 112740
ttgtatggtc aaactggggt aaatatgatt tacgatatta atgtagcaag aactccatca 112800
atggttacta ttccagctga agaattagat cgtcttcata aaattgaaga acttttttgg 112860
gaaattgaat ctgatttgcc atcaggatta gaatcctgga ttgattatga agaacttaat 112920
aagcttcggg gttaaacctt ggtgggcgga tagatgggaa actgtagagc cagagccgga 112980
agaaccggtt tacactgatg aagaaacagt atataatgaa cctacaataa atgacttaat 113040
tgatatggag atgggacatg attacagtag ataagtggtt tagaattaat cgtgctgata 113100
cagggctgtg taattactgg ccggaactta gtgcaggtac tgtctttaaa gttcgtgaac 113160
ttgcaaaaga atgtgaagat gatatagagc ctgacactgg aattattgaa attgaacttt 113220
ctggcggaaa ggttattaac atctatgata agccaattac gtattggtgc ttgtggaata 113280
ctgaatcagt cgaaaatggc gaaattgaag aagttgtaga acgagctgat caagctcttc 113340
ataaacctaa agccgctttt caaggtgaac gtatttcata cgcattagct aaattagctg 113400
cacaagaaaa taacgatggc tatgaaggta acctgatgca agctgccgca gagtacattg 113460
aatggcttga aactcaaatt tctttttctg accaaaagat tcggcaatat aagcgattgc 113520
atcaaatgtt ttataatact tgaaaaaact caaaattctt tttctgacag gacattttaa 113580
tgaaaaccga attggtttat actgaaaagt taaatggcgg taaggtttgg aaacttttta 113640
ttaaaggaca ttctacggac cctcatatga ccacttgcgt aggaacctat tctcgtccta 113700
ctaaaaagat gattcgacag tataaacgat tgcatcgaat gttttacaat acttaaaaat 113760
aataaatacc cttatctatt taaggtaagg gttttattat gttattgact ggcaaattat 113820
ataaagaaga aaaacagaaa ttttatgatg cgcaaaacgg taaatgctta atttgccaac 113880
gagaactaaa tcctgatgtt caagctaatc atcttgatca tgaccatgaa ttaaatggac 113940
caaaagcagg aaaggtgcgt ggattgcttt gtaatctatg caatgccgca gaaggtcaaa 114000
tgaagcacaa atttaatcgt tctggcttaa agggacaagg tgttgattat cttgaatggt 114060
tagaaaattt acttacttac ttaaaatccg attacaccca aaataatatt caccctaact 114120
ttgttggaga taaatcaaag gaattttctc gtttaggaaa agaggaaatg atggctgaga 114180
tgcttcaaag aggatttgaa tataatgaat ctgacactaa aacacaatta atagcttcat 114240
ttaagaagca gcttagaaag agtttaaaat gacaattgaa aaagaaattg aaggattgat 114300
tcataaaact aataaagacc ttttaaacga gaatgctaat aaagattctc gtgtttttcc 114360
aactcaacgg gaccttatgg ctggtattgt gtctaaacac attgccaaaa atatggtccc 114420
gtcttttatt atgaaagcac atgaaagcgg aattatccat ttccatgata ttgattattc 114480
ccctgctctt ccatttacta attgctgttt agtagattta aaaggaatgc ttgagaatgg 114540
atttaaatta ggcaatgcac agattgaaac tcctaaatca atcggtgttg ctactgcaat 114600
tatggcgcaa attactgcac aagttgcttc tcaccaatac ggcggaacga cttttgcgaa 114660
tgtagataaa gtactttctc cttatgttaa acgcacctat gcaaaacata ttgaggatgc 114720
agaaaaatgg caaatcgccg atgcactgaa ttatgcccaa tctaaaacag aaaaagacgt 114780
atacgatgct ttccaggcgt atgagttaat ttaattcagg ctcatgtaaa accggtctaa 114840
acggggaacc tctctagtag acaatcccgt gctaaatgtt cttttgaact aaatgcctaa 114900
cgactaaccg tgatgaatgt agcggtgtag aatagaagct aatgctattc gaaacggccg 114960
gcatcgaaag atgaagatat agtctaatct gcatggcgac atgcagcagt catcttgtat 115020
aaataagatt atcttatgaa tacgaggtga aacaatgaaa tggataaaaa gacgttgtac 115080
taaaataaaa gataaagacg catttacata cttagttaag ttttctaatg gcgacattta 115140
tatcggttat aaaaaattta gaacaattaa aaacaagccc acaaactgga aaacttacac 115200
aacgtcatct aagtatataa atgaacgctt aaaaactgat acacctacta aatggataat 115260
tttaaaaaca tttgatagtt ataaagatgc attaaaacat gaagaagagg tcatacgtaa 115320
atatttttat agcaaaaaat gtttaaataa atccataggc ggtaaaaagt tttataagca 115380
tccggatact gaagaacata ttcaaaaatt aagagatgct cataagggta aagtgttatc 115440
cgaatctcat aaaaacaata taaaatcttc tgtggctgaa tattatgcta aaaacagaag 115500
atctaaggaa catgtgcaaa ataatatcaa tagtcgaaaa agtaaaaaac aagtatcgat 115560
aaagcttaaa aataaaactt ttagaagttt taaaaaagca gcggaatatt taaattgcac 115620
tgaaagtgaa gtcgaaactc atcctcttgt tttgagtatt aagactacta ttcataaagt 115680
tcctgaatat gtggttgttg acggtattaa gtatacgtct tatatagaag cagctaaagt 115740
gctaaatttt catcctagca ctataaaaga acgttgcata tctatggact atccaaattt 115800
tgttgtttca tataaacggg catgaatttg cgactcatgc tgaatataat gatgaagtaa 115860
atactctctt tagttcaaac ggacaaacgc cttttgtaac aattacattt ggcacgggaa 115920
ctgactggac tgaacgaatg attcagaaag caattctgaa aaatcgtatt aaaggtcttg 115980
gtcgtgatgg gataactcct atttttccta aacttgttat gttcgttgaa gaaggtgtta 116040
atctttataa agacgatccg aactatgata ttaagcagct tgctttagag tgtgcaagca 116100
aaaggatgta tcctgatatt atttcagcta agaacaataa agctatcacc ggttcatcta 116160
ttcctgtttc tccaatgggt tgccgtagtt tcttgagcgt atggaaagat tcgactggta 116220
atgaaattct tgatggacgt aataatcttg gtgttgtaac actgaatctt cctcgcattg 116280
cgttagattc ttatattgga acacaattca atgaacagaa atttgttgaa ttattcaatg 116340
aacgaatgga tttgtgtttt gaagctttga tgtgtagaat tagttcttta aagggtgtta 116400
aagcgactgt tgctcctatt ctttaccaag aaggtgcatt cggggttcgt cttaaacctg 116460
atgacgacat aattgagtta tttaaaaacg gtagaagttc agtgtcccta ggatacattg 116520
gtattcacga attgaatatt cttgtcggtc gtgatattgg acaggaaatt ttaactaaaa 116580
tgaatgctcg tcttaagcag tggactgaaa gaactggttt tgcttttagt ttgtattcta 116640
ctcctgctga aaatctgtgc tatcgcttct gtaaacttga taccgaaaaa tatggaagtg 116700
taaaggatgt tactgataaa ggctggtaca ctaacagttt ccacgtttca gtagaagaaa 116760
atattactcc gtttgaaaag atttctcgtg aagccccgta tcatttcatt gcaacaggtg 116820
gtcacatttc ttatgttgaa cttcctgata tgaaaaataa cctaaaaggt cttgaggctg 116880
tatgggatta tgctgcacaa catttagatt attttggtgt taatatgcca gtagataaat 116940
gttttacatg tggaagtacc catgaaatga ctcctactga aaacggattt gtttgttcta 117000
tttgtggaga aactgatcct aaaaagatga acacaataag aagaacatgc ggatatcttg 117060
gaactcctag cgttgttcca tggaatttag gtaaaatgaa agaaatggta aaacgagtaa 117120
aacatgcata ggtattatat aatttataaa ataacaaata taattaattc aaaggaatat 117180
atcggtgcgc atagcaccga taacataaat gacggttata tggggtcagg aacattgatt 117240
cgtgccgctt tattaaaata tggtagaaaa aattttaata aagaaatttt acatgttttt 117300
gataatgaaa aacaaatgta tgataaagaa gctgaacttg taaccgaaga gtattgtcta 117360
aaagaaaata catataatat taaacctggt ggaaaaggtg gaactgccta tgaacagaca 117420
cttgaacatc gccgcaaaaa tagtttagca aataaaggta aaaagagaac agaagaaact 117480
aaaatagcta tttcacgtgc tttaaagaaa tataaacgta cgccagagca tcaagcaaat 117540
ttaaataaag ccgtaagcat agctatgaag cgaaaagatg ttagaagtaa attagctgga 117600
gagcggtctg agaaagataa attatctata tcaaacggtg ttaaaaaata ttacaattct 117660
ttgagtgaag aagaacgcga acttcatcgc aagcgaatta ttgaaggtaa aaagaattct 117720
cccatgtcat tggaatctag acaaaagctt tcaaaagctt taaaaggact tcaagttggt 117780
tcaaaaaatc caatgtatgg aaaaatttct ccaactagca aaaccgtttc agttgacggt 117840
attaaatatg attcaattaa aaaatgctca aacgccataa aagtttctag acatcttata 117900
ttaaaacgct gtaattctac tgatgaagct tggaaaaatt ggatgttatt atgaattacg 117960
atagatttta tccctgcgat tttgtgaatg gccctggatg cagggtcgtt cttttcgtta 118020
caggttgttt gcataaatgt gaagggtgtt ataataaatc aacatggaat gctagaaatg 118080
gcgttccatt cactggtgaa acactagaac aattaattga atgtttgaat aatgattata 118140
tagaaggatt aactataact ggaggagacc ctctttatcc tgataaccga gatgatgttc 118200
attgcattgt tcaaacagta aaaaatcttt atccgaataa aagcatttgg ttgtggacag 118260
ggtacaagtt tgaagatatt aaacaactag aaatgcttaa atatgttgat gttattattg 118320
atgggaagta tgagaaaaat cttccgacca aaaagctgtg gcgaggttca gataatcagc 118380
gactttggtc aaataccgat ggggtgtgga aacatgatta aattgaatta tattatggac 118440
actataaatg atatgatttt tcattttggt ccagaatttt attcgcagta tagtttagtg 118500
cttatcaatg cttggttaat caattaaggg taaaatatgt ataaatttcg taaaggttta 118560
gctgattttc ttacaaccgt aacgttcttt ttgtttatgg cagttggtgc tatttttctt 118620
attcctttta ttgctatatt tttcgtgatt agtttgattt ctccagaaaa aggcttatct 118680
tctagcgaat tcaatgagcg tctggataaa attactaaca agctgaatgc tgctcttagt 118740
aaggaatagt tgtgaaacaa aacaagattg aagtctatgg aattccagat gaagtaggtc 118800
gttgtcctgg atgtcaatca gttacaaaac ttctaaagga gctcaatgct ccttttactt 118860
tctataaagt tcttacaaat aatggtaaga ttgagtatga tcgtccactg attgtatctc 118920
ttgctaaacg cgctggattc acatctctta acattcgtta tccagtcatt ttcatcaatg 118980
attctagaca aaagaacatt aaacacttca aagaaactct catttcactt ggatatgata 119040
gagatatcat agaagactaa gacgggccct ttgggccttt ctttctcaca ttctgtatat 119100
taccattcta agctatcgtt cccttcttat cattccctaa aataattttc acaaagttgt 119160
ttacaagaag ttcaaactat ggtattatta acatatgaat tgcctttgag gatttgatat 119220
ggttgtggtt gataaagaaa ttaaaaaggg acaatattat tttattaatg gtaatgttgt 119280
tcgtgttact tacgtaaacg gttttgaagt ttattatctt atactcaagt tacataaaca 119340
gatgatttgt gaccgtgctg tatttagttc agttgctaag gaaattaaac tccatgggta 119400
aaacgtatcg tcgtaaagat ttaaaagtgc gtgattatga ctatttcgga aagcgtaaag 119460
ctcctgatgg tgtaagtcat aaagatatgg ttgaaaacat ttttcgctca gataaatggc 119520
gtagaatgaa aggcattgat tcagaagtta aagatgagct aaatcgtcaa ttgcgcagtg 119580
aagtaagaaa gttgaaaaaa tcagtttaca ttgatgatga ttttgattat aatacttctc 119640
aacgagttgc taaacgtaaa tcaaacgagt gctatcgtta cagctgagga aaatatgaat 119700
atcaaacgta tgctttttaa acaaggatta tacactttaa atgttgctcc aaaaggcgat 119760
acgaccaagt ggtcagtaaa tgactggatt aaattcattg atgaaaatgg caattggaaa 119820
atttaaatga atcctgaatc taaattatcg caacgaattg ccgaagctcg tcgtcagttc 119880
tttgaaaata tgatagccca aggtattgat gacgaagttt ttctgaactg gttttggaat 119940
cacaaatatt caagctgttc aggggcaata ttaatatcag ccgcaatgat gtatgaaggc 120000
tggaagggtg ccaaacagtt tagctaaggg cttcggccct ttttggataa taaaatttta 120060
acgtaattga ggataatgta tgactattca aattaaaaac gccatcaatt cttacgcata 120120
tgataaagta gtttctctgc tagaaaaagg cgatattgta actcctcaaa ttttggataa 120180
atgggaaaaa gagcttcatc agacgatgaa acagaatgat cagaaaattg gacgcaatac 120240
tgtccgtgaa ttgttggttc aatatatctt gtcagaattt gatgttaaag cttttggtgt 120300
agaatctaaa gcttatcaaa agcatgaaat ttctgataaa actattcgtc gtatgaaaaa 120360
tcaacgcaag aaaaaatttg ctgatctgaa aattactaag gcataattat gaatgaagct 120420
cttattaacg atttgcgtct tgccggatat gaagtaaata caaacggcat tggtttaact 120480
caaattgaag gaaatggatt catccttgag tatgaattta gccaatggtg gttatacgct 120540
aattacggcg aattgattga atacgttgac caatttgatt cactagatgc agctctcgaa 120600
gcggctaagt tgatgaatgt atgaaattta ttaatatttc tattactatt gaaaattatg 120660
gcattttcta tgttgaccaa tacatgaaaa tttcattttt cccaaataag actggtgttg 120720
gatattggga aagccatgtt tctgaattaa atgaaagcga atatgttagt acacatgaaa 120780
agtttttaga ctttttatat catgctgatc taactagtca ttatatagat attcatgaat 120840
ttaaaaagat gatggagaaa gtattccaag catactgttt acttagataa ctgatatcct 120900
ctatgcttta agatagatct tcaaatatta tgatataata gatctatgaa ttgagctaag 120960
aggtgaaaat gtcagaaact aagcctaaat ataattacgt aaacaataaa gagcttttac 121020
aagctattat tgattggaaa acagaattag caaataataa agacccaaat aaagtagttc 121080
gtcagaatga tactatcgga ttagccatta tgcttattgc agaaggctta tctaaacgtt 121140
tcaacttttc aggatacacc caatcttgga aacaagaaat gattgcagat ggtatagaag 121200
cttctattaa ggggcttcat aattttgatg aaacgaaata taaaaaccca catgcatata 121260
taactcaagc ttgttttaat gcattcgtcc aacgtattaa aaaagaacgt aaggaagttg 121320
caaagaaata tagttacttc gttcacaatg tctatgacag tcgtgacgac gatatggttg 121380
cgttagtaga tgaaactttt attcaagaca tctacgataa aatgacgcat tacgaagaat 121440
caacctatag aacaccgggg gctgaaaaga aaagtgttgt agacgattct cctagtttgg 121500
attttttata tgaggctaac gattaacctc tccggattct tggaagaaat acctgaagtt 121560
gaagctattc cctatttact taaaatgtat ctcagggaag ttttagctct tgacattgat 121620
attgatccag aaaatccgta tgataccgct tttaaatcta atggtgtaga attaaactat 121680
cggtatcatt taacagatga tgatttttat tttatattag agaaataata tgactgataa 121740
acccgaaatt aatgatgaag tggaaaagct tatttcttct attgaagaaa agaaccgtct 121800
tgaagcagaa agaaaagcaa ataagttatt gtctaaaaat aaacgcgaac tgaatcgtct 121860
ttataagcac gctcagatcg cagctgaaaa taataatttt gctcaatacg aatatgctat 121920
caagaaaagt cgggatattc taaaacagcc atataacgat gaactcatca gtattctttg 121980
gaagactact agatcgcaga ttgaggatat gattgatgct tacacacgta aaattcaagc 122040
gtcttaaaat taatgcagga tttactgaat ctttgaatgg tcatctttgt gtgaaaattt 122100
ctgaaaaaga ataccatgat agttcaatta aagaagttaa tcctcctatt gtaagagcag 122160
accctaatat gaaagtgtgg gttgattctt atcaagttaa aaaatggtgg caactgtgaa 122220
agatgaacat ccagacttct gaaatagatt ataataaaat tcgttcctct aaagtagaaa 122280
tgatgagacg ctttcaagag tcttacgata aagctaaagc agaaggaact ataacatata 122340
agcgcataaa atttagaagt tctaatgagc ctttgtatgg cgtattatgc ggataggagc 122400
ttcggctcct atattgcttt ataaattttt ggtaaaataa accaaaacaa agaggatatt 122460
aaatgaaagt atgtattttt atggctcgag gtcttgaagg ttgcggtgta actaaatttt 122520
ctcttgagca acgtgattgg tttattaaaa atggtcatga agtaactttg gtttatgcta 122580
aagataaatc atttactcgt aactgtgcac atgattataa atcattttca attccggttt 122640
tattggcaaa agaatacgat aaaacactta agctggtaaa tgattgtgat attctaatta 122700
tcaattcagt tcctgctact tcggttgaag aagacactat taataactat aaaaaaatta 122760
ttgataacat taaaccttct gttcgtgttg tagtttatca acatgaccat tcttctcttt 122820
ctttgcgtcg aaatttggga ttagaagaaa ctgttcgtcg agctgatgtt atttttagtc 122880
attctgataa tggtgatttt aataaagttc tgatgaaaga atggtatcca gaaactgttt 122940
ctctgtttga tgatattgaa gaagcaccga ccgtatacaa ctttcagcct cctatggata 123000
tcgcgaaggt tcgatcaacc tactggaaag atgtttctga aattaacatg aatatcaacc 123060
gctggattgg tcgtacgact acatggaaag gtttttatca gatgtttgat tttcatgaaa 123120
aacatcttaa acctgcagga ctaagtacta ttatggaagg tctggaacgt tctccagcgt 123180
tcattcctat taaagaaaaa ggaattccat acgagtatta tcgtcttcat caagtagacc 123240
aaattaaaat tgctcctaat ttgccaacgc aaattcttga ccgttatgta aatagcgaaa 123300
tgcttgaacg catgagtaaa tccggatttg gttatcagtt gagtaagttg gataaaaaat 123360
atctacaacg ctctttagaa tatactcatc tcgagcttgg tgcatgtgga acaattccgg 123420
tattttggaa atctactggc gaaaatttaa aattccgtgt tgataatact cctttgacct 123480
cgcatgatag cggtatcgtt tggtttgatg aaaatgacat ggaatcaaca tttgaacgta 123540
ttaaagaact gtcatctgac cgagctcttt atgaccgtga gcgagaaaaa gcgtatgaat 123600
ttttgtatca acatcaagat tcaagcttct gctttaaaga acagtttgac attattacaa 123660
aataaagggc ttcggccctt tagctttata cggagtttga tataatgata tttcttggat 123720
atgtgatact ttttcttgca ttttatctat tcactagagc atgctggatt gggttcttta 123780
gcactccaga tggatttatt tcaataattt tattttgcat ttcaatgacg gttcttgata 123840
tatgaaaatt ttaaatttag gtgattggca tttaggcgtt aaagccgatg atgaatggat 123900
tcgcggtatt caaattgatg gaattaagca agcgatagaa tattctaaga aaaatggaat 123960
tactgtatgg attcaatatg gtgatatttt tgatgtgcga aaagcaatca cgcacaaaac 124020
tatggagttc gcccgtgaaa tagttcaaat gcttgatgat gctggaatca cgttacatac 124080
tattgtagga aatcacgatc tccactataa aaatgtaatg catccaaatg cctctactga 124140
gcttttggct aaatatccta atgttaaagt atatgataag cctactacag tagattttga 124200
cggatgtttg attgatttaa ttccttggat gtgtgaagaa aatactggtg aaattcttga 124260
acacatcaaa acttcatctg cttctttttg tgttggtcac tgggaactga atggatttta 124320
tttttataaa ggaatgaaat ctcacggtct tgaacctgat ttccttaaga cttataaaga 124380
ggtgtggtct ggtcacttcc atactatttc tgaggctgca aacgtcagat atattgggac 124440
accatggaca ctaactgcag gtgacgagaa tgaccctcgt gggttctgga tgtttgatac 124500
agaaacagaa cgaatggaat ttattccaaa caatactacc tggcatcgta gaattcatta 124560
tccatttaaa ggaaaaattg actataaaga ttttacaaat ctatcagtac gtgttatagt 124620
aactgaagta gacaaaaatc taacgaagtt cgaatctgaa ctagaaaaag ttgtgcattc 124680
gttacgagtt gtgtcaaaga ttgataactc tgtcgagtca gatgacagtg aagaagttga 124740
agttcaatct cttcagacat tgatggaaga atacattaat gcaattccag acatcactga 124800
ttctgaccgt gaagcactta ttcaatatgc aaatcagcta tatgtagagg caacacaatg 124860
acttttgatg aatttaaaaa tgttatgatg agtcagcatt ttgaatgcga agtaaaagat 124920
gatattgggc ataaagaaat tattgaatat tggtttgaac cgttagaggt tgaagatagt 124980
tgtattaaaa aggttacggt ctgcactgac tgggctgtat cttttaactt caacatttta 125040
gataatgaca cacctaaatc attacaagat atggctgtat cttgtattaa ggatgcatat 125100
tgtgaagttt tcgacatttg acattaacga tgaattcata gcaaatattg attacaccga 125160
agaagattct agatatgttg gaataattta tatcacatca aaagcagcac aaggtgttgt 125220
ttgcatggct gaatttgatg aatacttttt agattatgat gatatgatag aatggtctaa 125280
aagatacatt aaaaggaatc ttttgtgaag aattttaaac ttaatagagt aaaatataaa 125340
aatataatgt cagttggtca aaatgggatt gacattcaat tagataaggt tcaaaaaact 125400
cttattactg gacgaaatgg cggtggtaag tctactatgt tagaagccat cacatttggg 125460
ctttttggca agccatttcg cgatgtaaag aaaggtcaat taataaacag cacaaataag 125520
aaagaacttt tagttgaact gtggatggaa tatgatgaga aaaagtatta tatcaaaaga 125580
ggacaaaaac caaacgtttt cgaaatcacc gttaacggta cacgtcttaa tgaatctgcc 125640
agcagtaaag atttccaagc agaatttgaa cagcttatcg gaatgtcata tgccagtttc 125700
aagcagattg ttgtccttgg tacagcaggg tatacccctt tcatgggttt gtcgacccct 125760
gcgcgaagaa agcttgtgga agacctgctc gaggtaggaa cattagctga aatggataag 125820
cttaataaag cactaatacg tgaattaaat tcacaaaacc aagtgcttga tgttaaaaaa 125880
gatagtatta tccaacaaat taaaatatat aatgataatg ttgaacgcca gaaaaaatta 125940
tctggtgaca accttactcg tctgcagaat atgtatgacg atttggcaaa agaagctaga 126000
acgctaaaat cggaaataga agaagctaat gaaagattag ttaatattgt tttggatgaa 126060
gacccgactg atgcatttaa taaaatcggt caagaagcag ttttgattaa atcaaaaatt 126120
gactcgtata ataaagtcat taatatgtat cacgaaggtg gattatgtcc aacctgtttg 126180
tcacaattaa gttccggtga taaagttgtt tctaaaatta aagataaagt ttctgaatgc 126240
acacattcgt ttgaacagct ttcaacacac cgtgataatt taaaagttct tgttgatgaa 126300
taccgagata atattaaaac ccagcagacg ttggcaaatg atattcgcaa taaaaagcaa 126360
tctctaatca cgacggtaga taaagctaaa aaagttaaag cggctataga aaaagcatca 126420
tctgagttta ttgaccatgc tgatgaaata gcactgcttc aagaagaact tgataaaatt 126480
gttaagacaa aaactaattt agtaatggaa aaataccaca gaggaatttt gactgacatg 126540
ctcaaagatt ctggtattaa aggtgctatt attaaaaagt acattccatt atttaataag 126600
cagattaacc attatcttaa aataatggaa gcagattatg tgtttacatt agatgaagaa 126660
tttaatgaga caattaaatc ccgtggtcgt gaagatttta gttatgcttc atttagtgaa 126720
ggtgaaaagg cacgaatcga tattgctctt ttatttactt ggcgtgatat tgcttctatt 126780
gtatctggtg ttagtattag tacattaatt cttgatgaag tgtttgatgg gtcatttgat 126840
gccgaaggta ttaaaggtgt agcgaatatt ataaattcaa tgaaaaatac taatgttttt 126900
ataatttcgc ataaagacca tgacccgcaa gaatatggtc agcatcttca aatgaagaaa 126960
gttggtcggt ttactgtaat ggtttaattt ataagagatt atgctttaat ttattagagt 127020
ataatctcta tggaggaaaa acatggaata ttcaactgga cagcatctat taactattcc 127080
tgaaataaaa cgatatattc tgagaaataa tttttctaat gaagagcata tagttactga 127140
atctatgctt aagaatgcat ttaaatcaga atatacgaaa ataatgtcca acagaaatga 127200
agcttggact gttactgatt attatgacta aaggtgtatt atgactaaaa ttactgtgaa 127260
ttatactgtt gatgtaaaag atattcagcc aaaacacgtg cgttctgaat caaatccaca 127320
aaaccaaaat aaaattcgtc gagcatgggt tttgtctctt tctgataacg cgatggaagt 127380
tattcagagc aaaattaaat ctgcacctgc tcgtcatgcg tattatgaag ctatcgatcg 127440
tgaagtaagt aataaatgga ttgaactaat gcgcaaacat acggcagaat ctctaaatgc 127500
tggcgctaaa tttattatga cttcatgtgg tgaacgcctt gaagatgatt attgcggtaa 127560
tgcagatgaa cgtctaattg ttgctgctca aattgttgcg gaaacaattg ctgctgattt 127620
taatcgttaa ttgctttatt aaattagtta taaaattaaa tctcatttga attgaaggaa 127680
attacatgaa actgtctaaa gatactactg ctctgcttaa aaatttcgct actattaact 127740
ccggtattat gcttaaatcc ggtcaattta ttatgactcg cgcggttaat ggtacaactt 127800
atgcagaagc aaatatttct gacactattg attttgatgt agcgatttac gatttgaacg 127860
gttttcttgg tattctgtct ctcgttaatg atgatgcaga aatttcccag tcagaagatg 127920
gtaatattaa aattgctgat gctcgttcaa caattttttg gccagcagcc gatccgagta 127980
cagtagttgc tcctaataaa ccaattccat tcccggtagc atctgttgtt actgaaatta 128040
aagctgaaga ccttcaacag ctgttgcgtg tatctcgtgg tctgcagatt gatacaattg 128100
ctatcacagt aaaagaaggt aaaatcgtaa ttaacggttt taataaagta gaagattctg 128160
ctttgactcg tgttaaatat tctttgactc ttggtgatta tgatggtgaa aatacattta 128220
atttcattat caatatggca aatatgaaaa tgcaaccagg aaattataaa cttcttctct 128280
gggcaaaagg taaacaaggc gctgctaaat ttgaaggtga acatgcgaat tatgtagtag 128340
ctcttgaagc tgattctacc cacgattttt aatagagggc ttcggccctt tataatttac 128400
actaaaactt gaatgaggaa attatgatta ctgtaaatga aaaagaacac attcttgaac 128460
agaaatatcg tccatctact atcgatgaat gtattcttcc cgcctttgat aaagaaacct 128520
ttaaatctat tacaagtaaa ggtaagattc cacatattat tcttcattct ccttctccag 128580
gaacaggtaa aacaaccgta gcaaaagcat tgtgtcatga tgtaaatgct gatatgatgt 128640
ttgtgaatgg gtcagattgt aaaattgatt tcgttcgtgg tcctttgact aattttgcta 128700
gtgcagcttc atttgatggt cgtcaaaaag taatcgttat tgatgaattt gaccgttcag 128760
ggttagcaga gtctcagcga catcttcgtt cctttatgga agcttatagt tcaaactgta 128820
gtattattat tactgctaac aatattgatg gtattattaa accgcttcag tcacgctgcc 128880
gagttattac gttcggtcaa ccgaccgatg aagataaaat tgaaatgatg aagcagatga 128940
ttcgtcgatt gactgaaatc tgtaagcatg aaggaattgc tatagctgat atgaaagttg 129000
tagcagcttt ggttaaaaag aattttcctg attttcgtaa aactattggt gagctcgata 129060
gttattcatc taaaggtgtt ttggatgctg gtattttatc actggttact aacgatcgtg 129120
gtgctattga tgatgttctt gaatctctca aaaataaaga tgttaaacag ctcagagctt 129180
tagcgccaaa atatgcagct gattattcgt ggttcgtagg taaacttgcc gaagaaatct 129240
atacacgtgt aactccgcaa agtattattc gtatgtatga aattgttggt gaaaataacc 129300
agtatcatgg aattgcggct aatactgaat tacatttagc atatcttttc attcaattgg 129360
catgcgaaat gcagtggaag tgatatgagc ttatttgaag atgatattca attaaacgag 129420
catcaagttg cttggtattc aaaagattgg acagctgtcc aatctgctgc tgattctttt 129480
aaagaaaaag ctgaaaatga gttttttgaa ataattggag ctatcaataa taaaactaaa 129540
tgctctatta ctcaaaaaga ttattcaaaa tacatggttg agaatgcatt atcacaattt 129600
cctgagtgca tgccagctgt atatgctatg aatttaattg gatcaggttt aagcgatgaa 129660
gcccatttta attatctgat ggctgctgtt cctcggggta aaagatatgg taaatgggca 129720
aaactggttg aagattctac tgaagtattg attattaagt tacttgctaa gcggtatcaa 129780
gttaatacaa atgatgcaat taactataaa tcaattctta ctaaaaatgg aaaacttcct 129840
ttagtattaa aagaactaaa aggtttagtc acggatgatt ttttgaaaga agtgactaag 129900
aacgtaaaag aacagaaaca actcaaaaaa ctagcattgg aatggtaaaa tgattgaaat 129960
tactcttaaa aaacctgaag attttctgaa agtaaaagaa actttgactc gtatgggaat 130020
tgctaataat aaagataaag ttctgtatca gtcctgccac attcttcaga aaaaaggact 130080
atactatatc gtccatttta aagaaatgct tcgtatggat ggtcgtcaag ttgaaatgac 130140
agaagaagat gaagttcgtc gtgattcgat tgcatggctg ttagaagatt ggggactgat 130200
tgaaatcgct cccggtcaaa gaacttttat gaaagattta actaataact tccgagttat 130260
ttcttttaag caaaaacatg aatggaaact cgttcctaaa tatacgattg gtaattaagc 130320
aaggggcttc ggccccttat ttggagtata atatatcaag agcctaataa ctcgggctat 130380
aaactaagga atatctatga aagaatttta tatctctatt gaaacagtcg gaaatagcat 130440
tgttgaacgt tatattgatg aaaacggaaa ggaacgtact cgtgaagtag aatatcttcc 130500
gactatgttt aggcattgta aggaagagtc aaaatacaaa gacatttatg gtaaaaattg 130560
tgctcctcaa aaatttccat caatgaaaga tgcacgagac tggatgaaac gaatggaaga 130620
cattggtctc gaagctctcg gtatgaacga ttttaaactc gcttatatca gtgatacata 130680
tggttcagaa attgtttatg accgaaaatt tgttcgtgta gctaactgtg acattgaggt 130740
tactggtgat aaatttcctg acccaatgaa agcagaatat gaaattgatg ctatcactca 130800
ttatgattca attgacgacc gtttttacgt ctttgatttg ttgaattcaa tgtacggttc 130860
agtatcaaaa tgggatgcaa agttagctgc taaacttgac tgtgaaggtg gtgatgaagt 130920
tcctcaagaa attcttgacc gagtaattta tatgccattt gataatgagc gtgatatgct 130980
catggaatat attaatctct gggaacagaa acgacctgct atttttaccg gttggaatat 131040
tgagggattt gacgttccat atatcatgaa tcgtgttaaa atggttctcg gtgaacgcag 131100
tatgaaacgt ttctctccaa tcggtcgagt aaaatctaaa ctaattcaaa atatgtacgg 131160
tagcaaagaa atttattcta ttgatggcgt atctattctt gattatttag atttgtacaa 131220
aaaattcgca tttactaatt tgccatcatt ctctttggaa tcagttgctc agcatgaaac 131280
caaaaaaggt aaattaccat atgatggtcc tattaataaa cttcgtgaga ctaatcatca 131340
acgatacatt agttataaca tcattgacgt agaatcagtt caagcaattg ataaaattcg 131400
tgggtttatc gatctagttt taagtatgtc ttattacgct aaaatgcctt tttctggtgt 131460
aatgagtcct attaaaactt gggatgctat tatttttaac tcactgaaag gtgaacataa 131520
ggttattcct caacaaggtt cgcacgttaa acagagtttt ccgggtgcat ttgtatttga 131580
acctaaagcg attgctcgtc gatacattat gagttttgac ttgacgtctc tatatcctag 131640
cattattcgt caggttaaca ttagtcctga aactattcgt ggacagttta aagttcatcc 131700
aattcatgaa tatatcgcag gaaccgctcc taagccaagt gatgagtact cttgttcccc 131760
gaatggatgg atgtacgata agcatcaaga aggtatcatt ccaaaggaaa tcgctaaagt 131820
atttttccag cgtaaagatt ggaaaaagaa aatgttcgct gaagaaatga atgccgaagc 131880
tattaaaaag attattatga aaggcgcagg gtcttgctca actaaaccag aagttgaacg 131940
atatgttaag tttaatgatg atttcttaaa cgaattatcg aattacactg aatctgttct 132000
taatagtctg atcgaagaat gtgaaaaagc agctacactt gctaacacaa atcagctgaa 132060
ccgtaaaatt cttattaaca gtctttatgg tgctcttggt aacattcatt tccgctatta 132120
tgatttgcga aatgctactg ctatcacaat ttttggtcaa gttggtattc agtggattgc 132180
tcgtaaaatt aatgaatacc tgaataaagt atgtggaact gatggtgaag atttcatcgc 132240
agcaggtgat actgattcgg tatatgtttg tgtagataaa gtaattgaaa aagtaggtct 132300
tgaccgcttt aaagaacaaa atgatttagt tgaattcatg aatcagttcg gtaagaaaaa 132360
gatggaacct atgattgatg ttgcatatcg tgagttatgt gattatatga ataaccgcga 132420
gcatctgatg catatggacc gtgaagctat ttcttgtcct ccgcttggtt caaagggtgt 132480
tggtggattt tggaaagcga aaaaacgtta tgctctgaac gtttatgata tggaagataa 132540
gcgatttgct gaaccacatc taaaaatcat gggtatggaa actcagcaga gttcaacacc 132600
aaaagcagta caagaagctc tcgaagaaag tattcgtcgt attcttcagg aaggtgaaga 132660
gtctgtccaa gaatactaca agaactttga gaaagaatat cgtcaacttg actataaagt 132720
tattgctgaa gtaaaaaccg cgaacgatat agcgaaatat gacgataaag gttggccagg 132780
atttaaatgc ccgttccaca ttcgtggggt gctaacttat cgtcgagctg ttagtggttt 132840
aggtgtagct ccaattttgg atggaaataa ggtaatggtt cttccattac gtgaaggaaa 132900
tccatttggt gataagtgca ttgcttggcc gtcgggtacg gaacttccaa aagaaattcg 132960
ttctgatgta ctgtcttgga ttgactactc aactttgttc caaaaatcgt ttgttaaacc 133020
gcttgcgggc atgtgtgaat cggcaggtat ggactatgag gaaaaagctt cgttagactt 133080
cctgtttggc tgatagaata aatctaggga cctccgggtc cctttttcat acaagtaata 133140
taaatctata cttaggaaaa atagatgatt ctggacctct ggaattcatt aaaaattttt 133200
tcacaaaact gtttacatct ctgttcttcc atggtactat atcaatatca actgatgcgg 133260
atttggagaa tgaaatgaaa atcgctattt tggttattgc attgggtctt actggttgtg 133320
tagctcaagg accagtagta aatcagtctg atgtaggaaa aattgtaaac tgttcaagca 133380
aattttataa tcctaatgtc aagtgttata aagaagctcc aaaacagaca gtagaacaaa 133440
tgcaggcgaa ttttgacgaa gctattcgtc cagatgaatc tgctcaagca tatcgtaatt 133500
cggatgtaat tacacgcgaa gaaaaaattg aaaattactg cgccgtgctt tgggcaaatt 133560
gggctaataa ttaccaatgg cgtactggta aaaatgctcc gatggagtat gtagtgaatt 133620
cttataattc atgcgtaaaa aatttgacta agtgaggaaa acatggaaac tttagtagca 133680
ggttcaattt ttatggtttt agtttcaggc gtgttggcta ttattatata catgcttccg 133740
tggttcatcg ccttgatgcg tgggtcaaaa tcgacagtag gaatcttttt cacatcttta 133800
ctgtttaact ggtcaattat tggttggttt attacattta tttggtcaat tgccggtgaa 133860
actaaaaaat ctgcacagca aaaccaagta attatcatca gagagaagga atgaaaagca 133920
aaattatagc agtgctgctt ttaatcttga tgattataat aagtatatac tatagtgtaa 133980
cggttcctct tatgattcca acgcttatta tagggtggag tttattactg ttacaagtta 134040
aatatgaatg tatcaattga ggtttaaatg attaatgact ctatgacagt tgaagaaatt 134100
cgtcttcatt tgggaattgc attaaaggaa aaagattttg taattgacaa aaccggggtt 134160
aaaactattg aaattattgg tgcatcattt gtagcagatg aaccttttat ttttggtgct 134220
cttaatgacg aatacattca gcgtgaactt gaatggtata agtctcaaag tctgtttgtt 134280
aaagatattc caggtgaaac accaaagatt tggcaacagg tagcatcttc taaaggcgaa 134340
attaactcga attatggttg ggccatttgg tcagaagata actatgctca gtatgacatg 134400
tgtttagctg aacttggtca aaatcctgat tctcgccgtg gtatcatgat ttatactcgt 134460
ccatccatgc aatttgacta caataaagat ggtatgtcag atttcatgtg tactaataca 134520
gtacagtacc tgattcgtga taagaaagtc aatgcagtag ttaacatgcg ctcaaatgac 134580
gtggtctttg gattccgtaa tgattatgca tggcaaaaat acgtactaga taaattagta 134640
tctgatttga atgcaggtga ttcaactcgt cagtataaag caggttccat tatatggatt 134700
gttggaagcc ttcatgtgta ttctcgtcat ttttacttgg ttgaccattg gtggaaaacc 134760
ggcgaaattc atattgcgaa aaaagattat aatggtgagt ggaaatgatt caattcgtaa 134820
ttccaagcta tcaacgcgta ggggcagttt ctgcccttga tatgtttcca tctgattatg 134880
aaccacatat tgtagtacgt gaacatgaag aaaaagctta ttatgacgct tacgggtcta 134940
gagctaaaat tgtagttatt cccgatgatg taaatggaat tgctggaact cgtaaagcaa 135000
ttactgatat gtatgcaggt cagcgaattt ggatgattga tgatgatact actattcgta 135060
tgagttcaat gcgaaagaaa gatgatcgtc gctgcgtaga taaaattaat cagttaactc 135120
gtgaacagtt ctatgaattg attcaatacg ttgaagatgc catggattgc gggtattatc 135180
atggtcatgc tcgtttacca atttttaaaa ttacttcatc ttggggtaat tatcgtgaaa 135240
attcatatgg attcacgaat acatggtatg accttggaaa acttacaaca gaacaaattg 135300
ggtatggaaa aattgattta tgcgaagata tgtatgcatt tctcaattta attaatcaag 135360
gttatccgca tttggccttg ttcaaatatc tggttgtatc tggaaaagca caagctcccg 135420
gtggatgcag ctcaattcgt agtaattcta aacataatag agcgcttgag caaatcaata 135480
gagaatttcc agagcaagct cgttggaaaa cttctaatat tgaaaaacga aaatcattag 135540
gtgaagaaga cgagccatta aaggttcttc gcatgtgtgt ttcgcgcaaa gaaaaatcag 135600
aagcgtttca taagtttaat gctattcatc caatagcagt tgattaatgc ctaaatttat 135660
tgtgttataa ttactctatc tttaaccagt gaggaaaata taatgatgcc tatggaaaaa 135720
atgaatgtct attgcagatt taaaatcccg tttgattaaa gcttccactt ctaaaatgac 135780
tgctgaactg actacatcta aattctttaa tgaaaaggat gtaatccgta caaaaattcc 135840
aatgctcaat atcgctattt ccggtgcaat tgatggtgga atgcagtctg gtttaactat 135900
tttcgcaggt ccttctaaac actttaaatc aaatatgtct ttgactatgg ttgcggcgta 135960
tttgaacaaa tatcctgatg cagtttgtct attctatgat agcgaatttg gtatcactcc 136020
agcttatttg cgatctatgg gagttgaccc ggaacgagta attcatacac caatccagtc 136080
agttgaacaa ctgaaaattg atatggtgaa tcagcttgaa gctattgagc gcggtgaaaa 136140
agttattgta ttcatcgact caatcggtaa tatggcttct aagaaagaaa cggaagatgc 136200
cttgaatgaa aaatctgtgg cagatatgac tcgtgctaaa tcactgaagt cattattccg 136260
tattgttact ccttatttta gtattaaaaa cattccatgc gttgcggtta accatacaat 136320
tgaaacaatt gagatgttta gtaaaaccgt gatgacaggt ggtacaggcg taatgtattc 136380
ggctgatact gtattcatta tcggtaaacg tcagattaaa gatggttctg atcttcaggg 136440
gtatcaattt gttctaaatg tagaaaaatc tcgtacagtt aaagaaaaaa gtaaattctt 136500
tattgatgtt aaatttgacg gtggtatcga tccttattct ggactgctag atatggctct 136560
tgaattagga tttgtagtaa aacctaaaaa tggttggtat gctcgtgaat ttcttgatga 136620
agaaaccggc gagatgattc gcgaagaaaa atcttggcgt gcaaaagata ccaattgcac 136680
tacattctgg ggtcctttat ttaagcatca accattccga gatgctatta aacgtgctta 136740
tcagttaggt gctattgata gtaatgaaat tgttgaagct gaagtcgacg aattgattaa 136800
ctcaaaggtt gaaaaattta aatctccaga aagtaaaagt aaatcagcag ctgatttaga 136860
aactgaccta gaacagttaa gtgatatgga agaatttaat gaataaagat gatttagatt 136920
tagatctaga aattatcgac gaatccccct cttcggaggg ggaagaagaa agaaaagaac 136980
gcctttttaa tgaatctctt aagataatta aatctgccat ggaaaatgtt atccaggaga 137040
ttgtcattaa actagaagac ggttctacac acattgtgta tgtgacaaaa ttagattggg 137100
ttgatggaaa agtcgtaatg gactttgctg ttcttgacca agaaagaaaa gctgagttag 137160
ctcctcatgt agaaaaatgt attacaatgc aactacaaga tgcatttaat aaaaggtcaa 137220
agaaaaaatt taaattcttt taaggagtaa gtgtggtaga aattattctt tctcatctca 137280
tatttgatca agcttatttt tcaaaagttt ggccatatat ggattcagaa tattttgaaa 137340
gtggtccagc taaaaataca ttcaaattaa ttaaatctca tgtcaatgag taccatagcg 137400
ttccatctat taatgcgtta aatgttgcat tagaaaatag ttcatttact gaaacagaat 137460
attctggtgt aaaaacactt atttcgaaac taaccgattc tccagaagac cacagctggt 137520
tagtaaaaga aacagaaaaa tatgttcagc aaagggcgat gtttaatgct acgtctaaaa 137580
taattgaaat tcaaactaat gctgagcttc ctccggaaaa acgaaataag aaaatgccag 137640
atgttggtgc tattcctgac atcatgcgcc aagcattatc aatttcattt gatagctacg 137700
ttggccatga ttggatggat gactatgaag cacgttggct atcttatatg aataaagctc 137760
gtaaggttcc atttaaactc aaaattctaa ataaaattac taaaggcgga gctgaaactg 137820
gaacactgaa cgttttaatg gctggtgtta acgttggtaa gtcattaggt ctatgttcat 137880
tggcagcaga ttatttgcag ctcggtcata atgttcttta catttcaatg gaaatggcag 137940
aagaagtctg tgctaaacgt attgacgcta atatgcttgg cgtttctctt gatgacattg 138000
atgatgggca tatttcttat gctgagtata aaggaaaaat ggaaaaatgg cgtgagaaat 138060
ctactctcgg ccgtttaatc gttaagcaat atcctactgg tggagcagac gctaatacat 138120
ttcgttctct tttgaacgaa ttgaagctca agaagaattt tgttccaaca atcattattg 138180
ttgactatct gggtatttgt aaatcttgtc gcatcagagt ttactcagaa aatagttaca 138240
caactgttaa agctattgca gaggaattgc gtgctctggc tgttgaaacc gaaactgttc 138300
tttggactgc agcacaggtt ggtaagcaag cttgggattc ttctgatgtt aacatgagcg 138360
atatcgcaga atctgctggt cttccagcaa cagccgattt tatgcttgcg gtcattgaaa 138420
ccgaggagtt agcagctgct gaacaacaac tcattaagca aatcaaatca cgatatggtg 138480
ataagaataa atggaataag tttttgatgg gtgttcaaaa aggaaatcaa aaatgggtag 138540
aaattgagca agattctact ccaactgaag ttaacgaagt agcaggttca cagcagattc 138600
aggctgagca gaatcgctat caaagaaacg aatctactcg agcccagtta gatgctttgg 138660
caaatgaatt aaaattttag tttacaagct gacaggacta tggtatagta gtcttgttgg 138720
ttaaatgagg agattgttat ggaattggta aaggtagttt ttatggggtg gtttaagaat 138780
gaaagcatgt ttactaaaga aatcacaatg atgaaagacg acgttcaatg ggctactact 138840
caatatgctg aagttaataa agcattagtt aaagctttca ttgatgacaa gaaagtatgc 138900
gaagtggatt gccgaggata atatgcacat tgttttattt aaacctactc cgtataatgt 138960
caggaaaaat actcaattca aagcacttgt tgcagatacg tgggaattgg tgttagatat 139020
tccagcagaa gaaagtcctc catttggtcg agtggaattt attaagtttg ctgtgcgccc 139080
tacgaagcga cagattcgcc aatgcaaaag atactttcgt aaaatcatca agttagagaa 139140
acagttattg atgctagtaa aataatagtt tacaagctga tagagttgtg ttatagtaat 139200
tctatcagct aatcgcggag aaaagaaaat gatgctagtt aatagagaat atcagtttaa 139260
atcagaagaa gatttggaaa aattcgcaag tggttgtgaa ctgaatagac gcacagctaa 139320
agtcatagga ttaaaaccct ttacagttct agattgtgaa gtttctaaat tccgcagagg 139380
gtgttctatt agcggtcatg ctctggttga tgggaacaca tttttctttg tttttagcgt 139440
cagagaactt ttattgatta acgaacttga ggaaataaaa tagtttactt ttgttggaaa 139500
ttgagatact atataaacat aaactactga ggagattatc atgaaaaaat ttgtttttgc 139560
tgcaattttt gctttggctt cttgtgctgc tcagcctgct atggcaggtt atgataaaga 139620
tttgtgcgaa tggtctatga ctgcagatca gactgaggtt gaaactcaga ttgaagcaga 139680
tattatgaat attgttgagc gtgatcgccc tgaaatgaaa gctgaagtac aaaaacagct 139740
taagtctggt ggtgtaatgc agtataatta cgttctgtat tgtgataaaa acttcaataa 139800
taaaaatatc atcgctgaag tggtaggtga ataattagag gctaatatga aaacgtttaa 139860
agaatttatc aaagaagata tggtcgctgg agattcaggt ggtaatcctg aaaatatctc 139920
tactggaaca acgtcaggcg ctgtagtaaa taaaggtcct gaacagattc ctaaaaagaa 139980
aaaagaggaa tctaaagaaa aagaagagta aaaatgtcat caataccttg gattgataat 140040
gagtttgcat atcgtgcgct agctcattta cctaaattca cacaagtaaa taatagttca 140100
acttttaaat tacggtttag atgccctgtt tgtggagatt caaaaaccga tcaaaataaa 140160
gcccgtggat ggtattatgg cgataataat gaaggaaata ttcattgtta taactgtaac 140220
tatcatgcac caatcggaat atatttaaag gagtttgaac ctgatttata tcgtgagtat 140280
atctttgaaa taagaaaaga aaaaggtaaa agtcgttcag tagaaaaacc taaagaactt 140340
cctaaacaac ctgagaagaa aataattaaa tctcttccgt catgcattag attagataaa 140400
ctggcggaag accatccaat tataaaatac gtaaaagctc gatgtattcc aaaggataaa 140460
tggaaatatc tttggtttac aactgaatgg cctaaattag ttaatagtat agcaccagga 140520
acatataaaa aggaaatacc tgagcctcgt cttgttattc caatttataa tgctaatgga 140580
aaagctgagt cttttcaagg acgtgcatta aagaaagatg ctcctcaaaa atatatcacc 140640
atcaaagctt atcctgaggc aacaaaaatc tatggagtcg aacgggttaa agatggtgat 140700
gtatatgttc tagaaggacc tatagattct ctttttattg aaaatggtat agctattacg 140760
ggtggtcaat tagacctaga aattgttcca tttaaagata gacgtgtatg ggttttagat 140820
aatgaacctc gtcaccctga cactattaaa cgaatgacta aattagttga tgcaggagaa 140880
agggttatgt tttgggataa atctccctgg aaatcaaaag atgtcaatga tatgattaga 140940
aaggaaggtg caacccctga acaaattatg gaatatatga aaaataatat tgcccaaggg 141000
ttgatggcta aaatgcggct atctaaatat gctaagattt aaattaaccc aactaaagca 141060
aatgctaaat ctacgaatgc atcaagagta attactggaa tactaacgcc atgagcaata 141120
gcaactggcg ataaaacaaa attccaaagt aaaattccta tcatagcaga aatagtaaaa 141180
gctatacgtt ttttattacc tttgatggca ttaacaagtg ccattaattt ttgtaccatg 141240
cgtcgtcctc ctttaaatta atatttatcg caaattttac aaaatttgtt tactttctca 141300
gcttgttatg gtattataaa ataaactgct gaggataata taatgattaa taaaattgtg 141360
catgaaatgg ctttaaacgg agattcatat aaaatatctg ccgtagttga gaatttcata 141420
cttaataaag taaaagaata tttcactgat tgttcagtta gttatcaaga aaaaatggtt 141480
ttaaccgacg atactgaaaa atcaaataat ttgttttgtt cgaattttat aactaagaag 141540
cgtactagaa gatttgatat tgtcatttct cgcaatggta aaaagcatat aattgaaatc 141600
aaacaccaag ttggtggagg tacagccatt gattcggttg gaatatatct ggaagataaa 141660
gataaattaa aagaatacac aaaaactgaa aatcctgtgt cattgatgat attagatttt 141720
ttgccatgtg gatattatcc gcgtaataag tggacaaaaa gagaatcatt tactgataat 141780
ccaaccatcc aagcaaggtt taatgaatat gctaaatcac aaaacgtgtt agtattacta 141840
tcaaatacat atgatgaaga attatataat ttgttttttg ctgcaataaa tgagagaata 141900
taatgctagg agctattgcg tatacaggta ataaacaatc attattacct gaacttaagt 141960
ctcactttcc aaaatatgac agattcgtgg atttattttg cggaggttta tcagtatctt 142020
tgaatgtcga tggtcctgta ttggctaatg atattcaaga accaattatt gaaatgtata 142080
aacgtcttat tagcgtgtca tgggatgacg ttttaaaagt aataaagcaa tacaaattat 142140
caaaaacatc aaaagaagag tttttgaaat tacgtgaaga ttataataaa actagagatc 142200
ctcttttgct ttatgttctt cattttcatg ggtttagtaa tatgattcgc ataaacgaca 142260
aaggaaattt tactactcca tttggaaaaa gaaccataaa caaaaatagt gaaaaacgtt 142320
ttaatcactt taaacaaaat tgtgataaaa taatttttag ctcattgcat tttaaagatg 142380
tcaaaattct agatggtgat tttgtatatg ttgatcctcc atatctcata acagttgccg 142440
attataataa attttggtca gaagatgaag aaaaagacct tttaaatctt ttagactctt 142500
taaatgacag aggaataaaa tttggattgt caaatgtttt agagcatcat ggaaaggaaa 142560
atacacttct taaagaatgg tctaaaaaat ataatgttaa gcatcttaat aaaaaatatg 142620
tctttaacat atatcattcc aaagaaaaga atggaactga tgaagtatat atttttaatt 142680
aattgcttta tatttaaatg atataattaa tctactaatc catgaattga aaggaaaaat 142740
aacatgccac atttcaacga atgtagtcat ctgatcgaag gcgctgataa agctcaaaat 142800
gaatactggg atattctcgg tgatgaaaaa gacccgctgc aagttatgct tgatatgcag 142860
aaatctttgc aagttcgttt agctaaagat aaacctgaat ataaccgtca tcctgatgat 142920
ttggctactg ctggtgaagt tgttgattgg ctgcgtaatc agaaagatta tattgacgat 142980
gaattccgtg aacttctgac ttctcttggc ggtatgagca atggcgaaaa agatgcatct 143040
gctgtatgga agccttggaa gtcgcagcat ggtgaacgtc gtgaaactct aattactgat 143100
ttgtctccac aagaccagtt ggaaattaaa ttcgaaatga ttgatattct tcatttcgtt 143160
ctgaacatgt tccaaggtct tggtcttacg gctgaagaaa tctttaaact ttattatctg 143220
aaaaatgctg aaaacttcgc gcgtcaagac cgaggttatt aatataaatg acggcttaaa 143280
agctgtgaga atttattata aatagtcatg taatttaaat aaaaggagaa ttacatggct 143340
agtactcgcg gttatgttaa tattaaaaca tttgagcaga aattagatgg aaataagaaa 143400
attgaaggaa aagaaatttc tgtagctttc cctctttatt ctgacgttca caaaatttct 143460
ggtgctcatt accagatatt cccttcagaa aaagcagcat atactactgt atacgaagaa 143520
aatcaacgtg atgcatggat tgctgcaaac gaagatctgt ggaaagtaac tggtggttaa 143580
taattcaagg actccttcgg gagtcctttt ttcattttgc cagtttactt ttcaaaatga 143640
gtatggtata ataaaactat cttatagagg agagcactat gttaaatcgc tggattaaac 143700
caaatgaaga ccttcagaag gttcttgata aagctatctc tgataaatgg ggtatgaaaa 143760
gctgggattg tgatatcgtc acgcattcat tcatgatgca tgcagatggt tcagtcgagt 143820
tcaatgctga aatgcgatac actgactggg gtggatttca aagagtcgaa tttcaaagag 143880
gctttttgta atgtttatct tcaattggtt taaaagtttc tttacggatt ttttctctac 143940
aactcccgga gaaggtgtag ttcctatttc aaatgactac cttcctttaa ctgtagttga 144000
atacgtttat atgggagatg gaacagtaga agcagttact atgacttatg aagaagccca 144060
agaatattat aaaaatcctt ggcgctggtc aacacctaca tcatctaatg cgcagaatac 144120
acagtctagt tctgattcat atgacactaa tgttcctgtt catgtatgga cgggagattc 144180
gtgtggaagt tcttgtgatt ctagttgttc atctacatct tgtgattgag gaaaattatg 144240
gaagcgattt tgtttgaaat gtatattagc agtaatagtt tgtcgtttgc taaagacgtt 144300
ccaattaccg tagcagtaat gattgataag ggttattgtg acccaatgta tctcgtagaa 144360
aattttgttt caatgccagt tccagaagat gctgaaataa aacttaaaaa gattggtatc 144420
attgaaactg taccaaatat tccgtttaga gcaattgaag catttactaa atccgaatac 144480
attaatgtta gcgcagaaca atataatgat aagcctttat ctttttattc gtacgattca 144540
ctatatagct ggaaaataga taaaggaaat aaatttataa ttgcaagtga agatgcttta 144600
tcatacttta tttcttctgt atggaatagt ttacatccaa atttgctaaa aattcatgaa 144660
tttgatgatg ctcctactgt tgttttgggt aaagtaaatg aaagttctga agaaaatgtt 144720
tgaatggttc aatagaccaa actcaatgta cattgatgat ggttgggttg aacaggcaaa 144780
taaagaaatg cagaatgaat cagaagaatg gatgaaatca atgattagtg ctgagaaaga 144840
aaagaaatta gaacgctcag cgcttaaatt gatgagagac atctatgggg ataaatcgtg 144900
aacagagata tgacgttaga agaggccaag gctaaagcaa atgaagcact ggatttgctt 144960
cttaaaatag gtaataaaat gatggaagaa aatgagaaat atatccagga aaacaaaatt 145020
cctgacggtc cattagtagg caaaaggaaa tcacatgatt gaagtagcaa aattatattc 145080
aatagaattt atgtctaaag aaggtaaatc agtaaataca cttgataaaa aatgctcatt 145140
aattattcct ttagcagaaa atccggatat tttaattaaa gatataaaag aaagaaaata 145200
tccagaaaat gttatcctaa ttataaagca tactgaagat attttgcaga atactgattc 145260
accattttct tcttctgaag ctttaactat taaaggctat aaaagagctc atgaatatgg 145320
tctttttgac ctgtttgaag acgataaagt taaattagcg agtcaacctt ctaaaagtaa 145380
aacattcatt attgaagata ttaaagatat aaatgcattt gttaagatgg tctgggctca 145440
ttttgatgtt ggactacgct ggagaatgtc cgaagaagaa agaaagatta ttgaagctaa 145500
tcgttatttt ggtttttatc gctaggaatt aatatggatt tatttgagat gttagaagat 145560
aatcattcta cgaatatcca gaatgattct agtgattata agaaagagta ccgtatagta 145620
ttacagaatt atggaattga agccccagat gctcttctag aagaattagc ttcataccat 145680
cttgaccctc cgccttgggc tccctgggca aaataattca aaaagttgtt tactttcctt 145740
cctaacaatg atatgatagc ttctgaagta tacggaggct atcatgatta ttaatcttgc 145800
agatgttgaa cagttatcta taaaagctga aagtgtcgat tttcaatatg atatgtataa 145860
aaaggtctgt gaaaaattta ctgactttga acagtcaatt ctttggcaat gtatggaagc 145920
caaaaagaat gaagctcttc atcggcagtt gaataaaatc attaaaaagc atttaactaa 145980
atcgccttat cagctatatc gtggtatatc aaaatcgaca aaagaactca ttaaagattt 146040
acaagttgga gaagtgtttt caacgaacag agtagattca tttactacta gtttgcatac 146100
agcgtgttct ttttcttatg ctgaatattt cactgaaata gtatttcgct taaaaactga 146160
taaagctttt aattattctg accatatcag cgatattata ctttcttctc ctaatactga 146220
gtttaagtat acatatgaag atactgatgg attagattca gaacgtactg ataacttaat 146280
gatgattgtg cgtgaacaag aatggatgat tccaattgga aagtataaaa taacttctat 146340
ttcaaaagaa aaattacacg attcatttgg aacatttaaa gtgtatgata ttgaggtagt 146400
tgaatgaaat attcagcaat gcaattaaaa gattttaaaa taaaatcaat ggatgcatcg 146460
gtgcgtgctt ctattcgtga agaattactt tctgaaggat ttaatttatc cgaaattgaa 146520
cttttaattc attgtattac taataaacca gacgatcatt cttggttaaa tgaaataatc 146580
aaatctcgtt tggttccaaa cgataaacct ctttggagag gtgttccagt tgagactaag 146640
caggtgttaa atcaaggaat tgatattatt acatttgata aagtagtatc agcttcatat 146700
gataaaaata tagctctgca ttttgcttct ggattagaat acaatacaca agttattttt 146760
gaattcaaag ctcctatggt atttaatttc caggagtatg ctataaaagc tctacgctgt 146820
aaagaataca gtccaagttt taagtttccg gatagtcatc gctatcgtaa tatggaatta 146880
gtttcagatg aacaagaagt aatgatacca gctggaagtg tatttagaat tgcggataga 146940
tacgagtata aaaagtattc aacatacact atctatactc ttgactttga aggatttaat 147000
ctataatgga aggacttaga ttcattatac catgaaagtt ttaaagcatt tttcataaag 147060
ttgtttacaa attaaagtaa aaatgttata gtataagtag ttaacccgtc cgtgagaaaa 147120
atatgaaact gactaataat caaattcgta aaattaaacg tcgtctagag catactcagg 147180
catctgctaa aagacgttct aaagatttta acttagactt caattacatt aagaacattt 147240
tagatcagaa agtttgcgct tactcgggag aaccttttga taatcgtatt gaaggagaga 147300
aattatcatt agaacgtttt gataataacg ttggatacat taaagggaat gttattgcag 147360
taaagaaaaa gtataataca tttcgttctg attatacttt agaagagttg attgaaaagc 147420
gtgatttatt tgctttgcga attggtcgtt catctgcgaa aaaagttcat aaactaaatt 147480
tagatgaaaa gaaatgggct aaaatcaaaa agacttataa tcaaattaaa gctatacaga 147540
aaaaacgtga aaaccgaatt gagcacattt ctcagctttc taaatcaaaa caaacttctg 147600
acgttaagct aacaattgta gcactcaaag ctcgtattga tggttctcgt atagcagaag 147660
gcgctgaagt tgttaaactg aacgttcttc ttaaaggctc ggattggaaa accgtgaaaa 147720
agttgtcaga agcagaaatg caatatgata tgtgtgataa aattattcaa ggtgtagagc 147780
ggtatcaaaa tttgtctttt attgataaac ttaaactgaa aagaggatac ccgctaaatt 147840
gttcaatttt taaacttatc cgaggataat atgttttatg tatatgcgat agtgtataga 147900
gataaagatg gatttgcggt gcctgttcct cttgatgaac atcgtcctgc tgtatttttt 147960
gaaagggaga ttgctgataa agtttttaca actcttaaag agcagtatcg actagcttta 148020
ggtatgggaa ttcctagatt agttgagact ccacgcaagt tttggtttaa taaaatagaa 148080
gttaaacatg ttaagcctga tgtagacaca caaagattat atcggcgaat tttagatact 148140
gggcgtattg ttagtatacc aattgcaggg aatttacgat gacatttgat gatttgaccg 148200
aaggccagaa aaatgccttt aacattgtta tgagggctat taaagaaaag aaacatcatg 148260
taactattaa tggacctgct ggtaccggta agactactct tactaagttc atcattgaag 148320
ctttaatatc tacaggcgaa actggaatta ttttagcagc tcctacacat gcagctaaaa 148380
agattctttc aaaactgtca gggaaagaag cgagtactat tcacagtatt cttaaaatta 148440
acccagtaac atacgaagaa aacgttcttt ttgaacaaaa agaagtaccg gatttggcta 148500
aatgcagagt attaatctgc gacgaagtat caatgtatga tagaaagcta tttaaaattc 148560
tgctttcaac tattccacca tggtgtacta taattggaat aggcgataat aagcaaatta 148620
gacctgttga cccaggagaa aacactgctt atatcagtcc attctttacg cacaaagact 148680
tttatcagtg tgaactcact gaagttaaac gcagtaatgc tcctattatt gatgtagcta 148740
ctgatgttcg taacggtaag tggatttatg ataaaattat tgacgggcat ggagtacgtg 148800
gatttactgg tgataccgct ttacgcgatt ttatggtaaa ttatttttca atcgtaaaat 148860
cactagatga tttgtttgaa aatcgcgtaa tggcatttac gaataaatct gttgataagt 148920
taaatagcat tattcgcaaa aagatttttg aaactgataa agattttatc gttggtgaaa 148980
ttattgtaat gcaggaacca ttaattaaaa catataaaat tgatggaaag cctgtgtcag 149040
aaattatttt taataacgga caattagttc gtattataga agcagagtat acatcaacat 149100
ttgttaaagc tcgtggtgtt tctggagaat atctaattcg tcattgggat ttaacagtag 149160
aaacttacgg cgatgatgaa tattatcgcg aaaagattaa aataatttca tctgatgaag 149220
agctgtataa gtttaactta tttttaggta aaactgcaga aacttataag aactggaata 149280
aaggcggaaa agcaccttgg agtgattttt gggatgctaa atcacagttc agtaaagtga 149340
aagcacttcc tgcatcaaca ttccataaag ctcagggtat gtctgtagac cgtgctttca 149400
tttatacgcc ttgtattcat tatgcagatg ctgaattggc ccaacaactt ctttatgttg 149460
gtgttacccg tggtcgttat gatgtatttt atgtatgatt aaatttgagg aagctattcg 149520
tggaaataac taaagatcag ttttatcttc ttcaagataa agtaagcgaa atttatgaaa 149580
tagcttatag caaaaatcgc aaaaatgtga aaactgaatc tagtaagttg atgcttcaat 149640
tagaagaaat tgaacgagat ttaattgcgt tagaattctt ttgtggtgaa gtaaaaactg 149700
ttacaatcag tgattatatt ttaggtgaaa ttagctatct ttataaggcg gttattaatg 149760
attgaattaa gttggtggca gtttaaatct cttataacaa atgttaaaga tgtcattgaa 149820
gaaaattcag gtcctgaaaa tattactatt cgcgaaaaag cttcaaagat agtatacagt 149880
cttgaagaga tacaaaaaga cattgaatct gtggcaaaat ttattgatga gcccattaat 149940
aaagtttata ttcaagacta tactgtaggt caaattcgcg atttagcaag gaaaatttaa 150000
tgtttgattt tattatagat tttgaaacaa tgggaagtgg tgaaaaggca gctgttattg 150060
atttggctgt tattgccttt gaccctaatc cagaagtagt tgaaacattt gatgaattag 150120
tttcacgtgg cattaaaatc aaatttgatt taaaaagcca aaaaggacat cgtcttttta 150180
ctaaaagcac tatcgaatgg tggaaaaatc aatctcctga agctcgaaaa aatattgcac 150240
cgtccgatga agatgtaagc actatcgacg gtattgcgaa atttaacgat tacatcaatg 150300
cacataatat cgatccttgg aaatctcaag gctggtgccg tggaatgtcg tttgattttc 150360
caattttagt cgatctcatt cgcgatattc aacgtcttaa cggcgtttcc gagaatgagc 150420
ttgatacatt taagttagaa ccgtgtaaat tttggaatca gcgtgatatt cgtaccagaa 150480
ttgaagcact tctacttgtt cgtgatatga caacgtgtcc ccttccaaag ggaactttag 150540
atggatttgt tgcgcataat tctattcatg actgtgcgaa agacatcctg atgatgaagt 150600
atgctttgcg atacgctatg ggtcttgaag atgctccatc agaggaagag tgcgatcctc 150660
tgtctcttcc aacaaaacga taaaaagttg tttacttcct cggttagttg tggtattata 150720
acaccatagc tactgaggat aataaaatga aaatttatcg tgttgaatca tcgtttagta 150780
ttcttaataa tgaagatgct ataacaatac gtcgaaatct ttgtgttcaa ataacgccgt 150840
acaggagtat aatagattca tggagcgaag agtggctatt acacgtaggt tatgacagac 150900
ctaattttat gcatcatagc gataataata aaagaattcc tttaccacac gaagacaaat 150960
tattagttaa aaacgctaat atagcaatta atactaagtt caagaaagat tatgttggag 151020
tagaatatca tattccagga tggtttatag ctctttatca ttttgctttc gctagtgaat 151080
atgatatgat gagatggttc acgcgagaag agcgggaaga attatcttct aaaggatttt 151140
atctcgctgt atacgaagtg ccagatgatc aagttgtcat tggtggacac caagtaatgt 151200
tccgcaaatc ccatgctgaa ctcgtagatt ttattgaaat gagataatta tgaaatttaa 151260
ttataatcct gaatacacac cgaatccggt agctaaactg attgattttg atgttgtaag 151320
cacttatgta tgccctgtta aaccactgga aattaaggaa cctactatga ctaccgctat 151380
tgaaatcggc aaaacctaca aactggttga aactgaaatt aaaactactg aactaagttt 151440
gggttataaa gcattgacca gtgttttggg tgaaggcgag tttgtggtta aaagtttttc 151500
aaaaagtaat tggcatgata agaataaagc ttatgtgatt cgagcacaac gcttagataa 151560
tgatgaagta attaaaacta tagtctttga agcagagctt atcctcttcc aagaatgcga 151620
tcctactgac cttctaactc gtgctgtagc tatcaagacc ccatttattt cggtctgtgg 151680
ttgggtaaca gaccagtgga ttgaagatgg tgttgagctt ctgaacgttg tccatgcagg 151740
agattttagt gtagtacctc gtagtgcggt ggtagctatt ttgaattaat agtttacaaa 151800
ctcttgggac cagagtataa tggtcctgtg gagtataaaa tctttttaac aagtgagaga 151860
taactatgat tattaatatt ggtgaaattg ctcgtgtatc tgataaatcc cgctctaaag 151920
cagcaggaaa attggtcgaa attgtaagca ttcagcttaa acacggcgtt aaagatgaag 151980
attctgaagt aaaagtgcgt atcattccta aagatggaaa gtctaaacct cagtttggtt 152040
atgttcgcgc gaaatttctt gaatctgcgt ttttgaaagc tgttcccgct aaaggaattg 152100
aaacgattga tacttcgcat gtaggtgtag actttaagtg gaaactcggt caagctatta 152160
agttcattgc tccttatgaa ttcgaattta ctgaagatga ggaaggggtt gttcaaaaac 152220
gccgtactcg tgctatgtgc gcatacatta ccgatcagtg ggtagaagat ggtgttaagc 152280
tgtacaatgc ggtattttta ggaacataca aagtcattcc tgaaagttgg attaaacact 152340
atagcaaagc tcgctgtgca taaagtttaa aatttttttc ataaaactat atacatcagt 152400
agttgattat ggtactatat caatatcaac tactgataca gaaaacaact tggagaataa 152460
aatggaaatt cgccaaaggt gctgatactc ttctgaaacg catcgctcca atgtttaatt 152520
aatgaggaaa ttgtaatgaa acgtaaaatt gttcagaatt gcactaatga tgaatttgaa 152580
gatgtattat tcgatccaga tttggtagta gttcaaaagg aacatactag caagtttact 152640
cacttgactt ctgtttatgt gtatgagaaa gtcggtgata aacagccaat ttacggtgta 152700
tttcgtgaaa ttactgaaaa tggcacaact tactggaagg aaatttatta atggctatta 152760
aatttgaagt taataaatgg tatcaattta aaaataaaca agctcaagaa aattttatta 152820
aagaccatac tgataacgga atctatgcgc ggcgtttagg tatggaacct tttaaaattt 152880
tagatgttga ctattacggg cgtcctacta aaattgtgac atctactggc atagttggat 152940
attcatcacg aggtacagtc attgacgaaa actttatctg gctttctagc aacgaagccg 153000
agttctttaa tgaagtggaa aatccatatc aggctgctga agagcaggaa gaccctgcac 153060
cagtaactga accatctgaa ttcccggtaa tgaaagttac tattgaaaat aatgaacaag 153120
catggtcctt gtatcagatg ttgaaagctc actttaagga ataattatgc ctctttatga 153180
ttataaatgt caatccaaag actgtgcaaa agaatacgaa aaaatcaaga aaatttctga 153240
aagagatact gatgtatgtc ctgattgtca tcggattgct attcggttag tttccgctcc 153300
taagcatgtg aacggtggat tttacgacct acttaaaggg taattatgaa atatgttaat 153360
cgttctatcg cggcattagt attagcagta tctttagtag gatgtactga tgctgataat 153420
gcaaccaaag ttttgtcttc aagtggtttt actaatattg aaatcactgg atataattgg 153480
ttcggttgct ctgaaaatga tttccagcat actggatttc gtgctattgg acctactggg 153540
cagaaagtag aaggaaccgt atgttctgga ctattcttca aggattcgac tattcgtttt 153600
aaataaaagg ccttcgggcc tttagcttta tgattaccgg agtataatat tcccgaaacc 153660
aaacgaggat aagtgatgat taagaatgaa attaaaattc tgagcgatat tgaacatatc 153720
aaaaagcgta gcggcatgta cattggctct tcagctaatg aaatgcatga gcgctttctg 153780
tttggtaaat gggaaagtgt tcagtatgta cctggtcttg ttaagcttat tgatgaaatt 153840
atcgataact cagtagatga aggtattcgt actaagttta aattcgcgaa taaaattaat 153900
gttactatta aaaacaatca agtaacagtt gaagacaacg gtcgtggtat tccacaagcg 153960
atggttaaaa cacctaccgg cgaagaaatt cctggtcctg ttgctgcctg gactattcca 154020
aaagcaggtg gtaacttcgg tgatgataaa gaacgcgtca ctggcggtat gaacggtgtt 154080
ggttctagtt taactaacat tttttctgta atgtttgtcg gtgaaactgg cgacggtcaa 154140
aataatattg tagttcgttg ttcaaatggc atggaaaata aatcatggga agatattcct 154200
ggaaaatgga aaggaactcg tgttactttc attcctgatt ttatgtcatt tgaaactaat 154260
gagctatctc aagtttatct tgacattaca ctagatcgtc tccagacact tgcagtagtt 154320
tatcctgata ttcaatttac ctttaatggt aaaaaggttc agggtaattt taagaaatat 154380
gcacgccaat atgatgagca tgctattgtt caagaacaag aaaattgttc tattgcggtt 154440
ggtcgttcac cggatggttt tcgtcaatta acatacgtca ataacattca cactaagaat 154500
ggtggccatc acattgactg tgttatggat gatatttgtg aagaccttat tccacaaatc 154560
aaacgtaagt tcaaaattga tgtgactaaa gcacgtgtca aagaatgttt gactatcgtt 154620
atgtttgtcc gtgatatgaa aaacatgcga tttgattctc agactaaaga gcgtttgact 154680
tctccatttg gtgaaatccg tagtcatatt cagcttgatg ctaaaaagat ttcacgcgct 154740
attctaaata atgaagcaat tctaatgccg attattgaag ctgctttggc tcgtaaattg 154800
gcggcagaaa aagcagcaga aactaaagca gctaaaaagg cttctaaagc taaggttcat 154860
aaacatatca aagcgaatct ttgtggtaaa gatgctgata ctacattgtt cttgactgag 154920
ggtgattctg ctatcggata tcttattgat gttcgtgata aagaacttca tggtggttat 154980
ccattgcgtg gtaaagttct caacagttgg ggtatgtcat atgctgatat gcttaaaaac 155040
aaagaactat ttgatatttg cgcaatcact ggattagttc ttggtgaaaa agcgtttgaa 155100
gaaaaagaag atggcgagtg gtttactttc gaactaaatg gcgatacaat tatcgtaaat 155160
gaaaatgatg aagtacagat taatggtaaa tggataacag taggtgaatt acgaaaaaat 155220
ctataatgac ttaatagtgc ggggtaaaac ccgcgtttct aaatttaagg gtgaaattca 155280
tcatatcctt ccaagatcaa tgggaggttc tgatgataaa gaaaatttgg tgaaactgac 155340
ttttcgtgaa caccttttag cacattttct actatataaa attcatcgta atcgtgaaat 155400
ggcatatgcg atgaatagaa tgttaaacac tgaaaaatat ttacgttcta gtaaattata 155460
tgaaattgct agaatttacc atcaaagagc agtatctgaa tggtcaaaaa actttatgaa 155520
agataaagtt ttaatgagaa gtattaaatc gggtaaatgc gccttattaa ttaaaggatc 155580
atttaaccca aaggaatggt gcggtgttaa taaaggtgtt aagcttcctg gaattaaagg 155640
catgacgtgc tttaaaaatg aaaaaggcga agtttttcgt cttcatgtta atgatccacg 155700
cattaaagct gaaaaattag ttggtattgg aaatactgtt gctgctactg caaaagcagc 155760
tgaacttgaa aaagcgaaac catggtataa taaatcagcg acaaatccag aggctgtaaa 155820
attaacacca aatttatatg aatggtacgt cacgaaatat gaccccgatc attataaacg 155880
aacgggagtt gctaaatgga aatcagttaa taatataact gtgaattcaa aattattcgg 155940
ccgagcattt aatgaattta aacgcggctg gattcctgat gaaaagttct acgaggtgta 156000
taatgaaatt tgtaaaaatt gattcttcta gcattgatat gaaaaaatat aaatcgcaga 156060
acaatgtccg tcgttctatt aaatcctctt caatgaacta tgcgaatgtc gctattatga 156120
cagacgcaga tcacgatgga tagccttcgg gctatccatt gaaatacctc ataattaaga 156180
gattattgga ttaggttcta tttatccttc tctgctcgga ttttttagta attggccaga 156240
attatttgag caaggaagaa ttcgcttcgt caaaactcct gtaatcatcg ctcaggtcgg 156300
taaaaaacaa gaatggtttt atacagtcgc tgaatatgag agtgccaaag atgctctacc 156360
taaacatagc atccgttata ttaagggact tggctctttg gaaaaatctg aatatcgtga 156420
gatgattcaa aacccagtat atgacgttgt taaacttcct gagaactgga aagagctttt 156480
tgaaatgctt atgggagata atgctgatct tcgtaaagaa tggatgagcc agtagtttac 156540
tttaccacaa ggatgtggta taattaattg ggcaaatgag gatattgaaa tgaaatcata 156600
cagagtaaat ttagaacttt ttgataaagc agttcatcga gaatatagaa tcattcaacg 156660
ctttttcgat atgggagaag ccgaagaatt taaaaaccgc tttaaggata ttagagataa 156720
aattcaatct gacaccgcaa ccaaagatga attactagaa gttgctgaag ttattaagcg 156780
taatatgaat taatgaggaa attatatgat tatcaccact gaaaaagaaa caattcttgg 156840
taatggttct aaatcaaaag catttagcat cacagcatct cctaaagtat ttaaaattct 156900
gtcatctgat ttgtatacaa ataaaattcg cgcagttgtt cgtgaattga ttaccaacat 156960
gattgatgcc catgcactta atggaaatcc tgaaaaattt attatacaag ttcctggacg 157020
tttagaccca cgatttgttt gtcgagattt tggtccgggt atgagtgatt ttgatattca 157080
aggtgatgat aattctcctg gtctgtataa ttcatacttc agttcatcta aggctgaatc 157140
taacgatttc attggcggat ttggtttagg ttctaaatct ccgtttagtt atactgatac 157200
atttagtatt acttcgtatc ataaaggtga aattcgcggt tatgtagctt atatggatgg 157260
tgacggtccg cagattaaac ctacattcgt aaaagaaatg ggtccagacg ataaaactgg 157320
tattgaaatt gtagttccag ttgaagaaaa agactttaga aactttgctt atgaagtttc 157380
ttatatcatg cgaccattca aagatttggc tatcattaat ggtcttgacc gcgaaattga 157440
ttattttccg gattttgatg attattacgg cgtaaatcca gaaagatact ggccagatcg 157500
tggtggattg tatgctatct acggcggtat cgtttatcct atcgatggtg ttattagaga 157560
ccgtaactgg ctaagcattc gcaatgaagt gaattacatt aagtttccaa tgggttcact 157620
tgatattgct ccatcgcgtg aggctctttc actagatgat cgtactcgta aaaatattat 157680
tgagcgcgtc aaagagctta gtgagaaggc atttaatgaa gatgtaaaac gatttaaaga 157740
atctacatct cctcgtcata cataccgtga attgatgaag atgggatatt ctgctcgaga 157800
ttatatgatt agtaattcag tcaaatttac gactaaaaat ctgtcatata aaaagatgca 157860
gagcatgttt gaacctgata gtaagttatg caatgcaggg gttgtgtatg aagtaaatct 157920
tgaccctcga ctgaagcgca ttaagcaaag tcatgaaaca tcagccgttg cgtcaagtta 157980
tcgtctgttt ggtattaata caacaaaaat taatatcgtt attgatgata ttaaaaatcg 158040
tgttaatatt gttcgtggat tagcacatgc gttagatgat agtgaattta ataacacttt 158100
aaatattcat cacaatgagc gtcttctgtt tattaatcca gaagtagaat cgcagattga 158160
tttactccct gatattatgg cgatgtttga aagtgatgaa gttaacattc attatttgtc 158220
agaaattgaa gctttagtta aaagctatat tccaaaggta gttaaaagta aagctcctcg 158280
tcctaaagct gctacagcat ttaagtttga aattaaagat gggcgatggg aaaaagagga 158340
actgtttaca cttacgtcag aagcagatga aattactggt tatgtagcat acatgcatcg 158400
ttctgatatt ttctctatgg atggtactac atcgctttgt catccatcta tgaatatttt 158460
gattcgtatg gctaatctta ttggcattaa tgaattttat gttattcgtc cgcttttaca 158520
gaaaaaggta aaagaactcg gtcagtgcca atgtattttt gaaactctgc gtgatttata 158580
tgtagatgct tttgatgatg tagattatga taagtatgta ggttattcaa gttcagctaa 158640
acgatatatt gataaaatta tcaagtatcc tgagctagat tttatgatga agtacttcag 158700
tgtagatgaa gtttctgaag aatatacacg actcgctaat atggttaatt cattacaggg 158760
tgtatatttc aacggtggaa aagataccat cggtcatgac atctggacag taactaatct 158820
ttttgatgta ttatcaaata atgcttcaaa aaacagtgat aaaatggttg ctgagtttac 158880
caagaaattc cgtattgttt ccgacttcat cggttatcgc aactctttaa gtgatgatga 158940
agtttcccaa atcgctaaaa ctatgaaggc ccttgcggcc taataaggaa aattatgtac 159000
aatattaaat gcctgaccaa aaacgaacaa gctgaaattg ttaaactgta ttcaagtggt 159060
aattacaccc aacaggaatt ggctgattgg caaggtgtat cggttgacac aatccgtcgt 159120
gttttgaaaa atgctgaaga agctgagcgt tccaaagtta ccattagcgg tgacattaca 159180
gttgaagtta agagtgatgt agctattgct ccagttgcta aatctgacat tatttggaat 159240
gcatctaaaa aattcatttc aattactgtt gacggtgtaa cttataacgc aactcctaat 159300
actcattcaa acttccagga aattcttaat ctgcttgtag cggataagct ggaagaagca 159360
gcacaaaaaa ttaatgttcg tcgcgctgtt gaaaaatata tttccggtga tgttcgaatt 159420
gaaggcggaa gcttgttcta tcaaaatatc gaattacggt ctggtttagt tgatcgtatt 159480
ctcgattcga tggaaaaagg cgaaaacttt gaattttatt ttccgttctt ggaaaatctg 159540
ctggaaaacc caagccaaaa agcggtatct cgactctttg atttcttggt agcaaacgat 159600
attgaaatta cagaagatgg ttacttctat gcttggaaag tagttcgcag caattacttt 159660
gactgtcact caaacacctt tgataacagt cctggtaaag tagttaaaat gccacgtact 159720
cgtgtgaatg acgatgatac acaaacttgt tctcgtggtc tgcatgtgtg ttctaaatct 159780
tatattcgtc actttggtag ttcaaccagt cgagttgtaa aagttaaagt gcatccgcgc 159840
gatgtagtat caattccgat tgattacaac gacgctaaaa tgcgtacctg ccaatacgaa 159900
gtagttgaag acgttactga acaatttaaa taagggcttc ggcccttaac taaggaaaat 159960
tatgttaggt tatcaagcac gagtaaaaga agaatacgat caattaatgc tcaaaattaa 160020
tgcacttagt aaatttttag aaagtgaaaa gttttcaacg gttaatgcag ttgagcaaga 160080
actgctgctt tcacagttta tctcaatgaa atcttacgca gattgtttag agaaaagaat 160140
tgcacaattc aaataaaata aggggcttcg gcccttttgt tttaaggaaa attatgattt 160200
attgtatgaa tatcggtgat tccgacataa aagaaatttc tctacacgga aatcatcacg 160260
ctaatattgt gtactgtaat aaatttgagt ttggtcacga aaaacttgga gttctttact 160320
gcaatgatgt tatagtcatg gataaaaaga atctcgatga acttgatcgt aattctttag 160380
atgaaaatga tcgaatttat tatggtactc ttaaagtata taacgcttat cttagtggta 160440
aaaaggaaag tctaaatgca gaaaacgaat ccaggtttac agagactatt tcagattccg 160500
acatttaccc tatcgaacaa tgatttgact agtgaaatga aggtcaaaat tgctgataca 160560
gcaagatact ctttaaaaca aaacccgaac caggataaag cggaagttat tgaaagatgt 160620
cgtattgctg tgtacgcaga gttttttgta gcagattggc taagcgggta tgttaacaaa 160680
ggtcaagaag atgtcgatga tccgtacacg tatgcatggg atgttttagc acatccaaaa 160740
tactgcgggc tccgtgtaga agttaagaca catcaaactg actcacgttg gatttctgta 160800
acaacaggat gcagcggaga gtatccatat ggttctggaa taaatctagg gcccattcta 160860
aatcatcaag tcgctgactg tataattata ttcaacacta aagaaattca tccaggtgtc 160920
atccagtaca ctccgaagtt catcggtgac agagaagacc ttcgtaaggt tgtaagaaaa 160980
agcaactaca atggatggta tctttccatt taaaaaattt cacaaaacag tttacatacc 161040
acaaggaccg tggtactata caactatcaa ctacagagga acaaaaatga aatttaaatt 161100
cttttatgtt aaacataaaa tcacaggtga atttgttcat gtacaatatt ctgaaattga 161160
cgatgcaaca tcatttattt cattgggatt gtctaaatat gaatcagacc aaccatatct 161220
tactgataaa ttgcaacaag agcgtttgtt gaatggtgat ttaaacaatt cttgggaagt 161280
tcttatttac gatgatttag agaaagctat taaagaaaat aatcttgaaa tcattgagat 161340
tgaactatga gttcactatg gtggtgtttt gtttggttaa ttagtattcc agtaatttgt 161400
ttaacattta cttttgtgat gaggttatta tgaaaattat gaattctgta cttattgctt 161460
gcgcgtggtg ggttgcgcag gtttcggcgg tagtagttgg tattcacatt tattacgaat 161520
atttttaaaa aagttgttta caagactgtt cttccgtggt actattaccc tatcaactac 161580
ggaggaacag aaaatgaaaa agattgttaa agctatatgg aatgtagtta taatactaat 161640
agttttgagt atattcccaa tcgttttaat gattgatgta ttaaacgctt actttggatt 161700
tatgtgagga aaatatgaag cgtaaacgta gtgcttttac atttattgaa tggtttttcg 161760
ataatatttt tccggcttta ttcattttca tgctgatttt tgccttaggt tcagttgtag 161820
ttggaatcta tttgatgaca gtagtcggaa ttgatattca tcaaaatggt ttaaaatccg 161880
tagttgaaac aatttggaat ggtgtaaaat gatgaattta ctaaacattt ggttttatat 161940
tcttatgttt tacattggcg caaatttccc atattggatg ggatggtcaa cagttgcatt 162000
cggattttat acgccttgag gtgaattatg aaaagcttta aagatgtaaa agttggtgaa 162060
attttctgtt tagataacgg tgatcagtta attcgtattt cacctcttaa gagcactagc 162120
gagaaaccga cagttaatgc tactttagca aataacagta atgaacgttt ctgtattgaa 162180
aatgatactg aaacttatac tgtagaagag ttttgggaat tgagtgtcga ctgcgacgat 162240
taatttaatt ggccgcgtat tcatgcggcc atggagtaga aaataattta gaggaaatta 162300
atatgaaata tatgactgtt actgatctga acaacgcagg cgctactgtt attggtacaa 162360
tcaagggtgg tgagtggttt ttgggaactc cgcataaaga tattttatct gaacctggat 162420
tttacttttt agtaagcaaa tttggtggtc catttgatag tccgtgtgta tctgcacgat 162480
tttatgtagg taatcagcgt tctaaacaag gattcagtgc agttttaagt catattcgtc 162540
agcgtcgatc tcagcttgcg cgtactattg caaataataa tgttccatac acggtatttt 162600
atctacctgc ttctaagatg aaacctctga cgacgggatt tggaaaaggt cagttaactt 162660
tagcgtttac tcgtaatcat cattctgagt atcaaacgct tgaagaaatg aatcgtatgt 162720
tggctgataa ttttaaattt gttttgcagg catattaatg agcaatttcc ataacgaaca 162780
tgtgatgcag ttttatcgta acaatcttaa aactaaaggc gtcttcggac gccagtgagg 162840
aaaatatgaa tattgcgaaa ctattaggag ttatttcatt tatttgttgg atagtagcat 162900
gtgttttaac tatctgtatc gatgctagca gtgtgttttc acaagcttta gcccagggta 162960
tgtgtgcata tttaacattt gcgttgttat ctaatgatta agaaaatctt gggctactcg 163020
gtagcccttg ctgctttatt ggtagcacta tattatggag taatgttcgg attaattcaa 163080
gtcgtgcttt tcatttctga tgttattatg gcactacatt cactagtatg gtaaatttat 163140
gcaactgaat aatcgcgatt taaaaagtat cattgataat gaagcattgg cttatgctat 163200
gtacacggtt gaaaatcgtg ctattccaaa tatgattgat ggatttaagc cagtccaacg 163260
atttgttatt gctcgagctc ttgatttggc acgaggaaat aaagataagt ttcacaaact 163320
cgcttctatt gcaggtggtg tagctgacct tggatatcat catggtgaaa actctgcgca 163380
agacgcgggg gctttgatgg ctaatacttg gaataataac tttcctctat tagatggtca 163440
aggaaacttt ggttctcgta ctgtccaaaa ggcagcagca agtcgttata tttttgctcg 163500
tgtaagtaaa aatttctata acgtatataa agatactgaa tatgctccgg tacatcaaga 163560
taaagaacac attccgcctg ctttctattt gcctattatt cctactgttc ttcttaatgg 163620
cgtttccggt attgcaactg gttatgcaac ttacattctt cctcatagtg tttcttctgt 163680
taagaaagct gtactgcaag ctcttcaagg aaagaaagta actaaaccga aggtagaatt 163740
cccagaattt cgtggtgaag tcgttgaaat tgatgggcaa tatgaaattc gtggaacgta 163800
caagtttact tcacgaactc aaatgcatat cactgagatt ccgtataagt atgatcgtga 163860
aacttacgtg agtaaaatct tagacccgct tgaagataaa ggcttcatta catgggatga 163920
tgcttgcggt gagcatggtt ttggctttaa aattaaattc cgcaaagaat actctttgag 163980
cgataatgaa gaagaacgcc atgcaaaaat catgaaagac ttcgggttga ttgagcgtcg 164040
ttcccaaaat attaccgtta ttaatgagaa aggaaagctg caagtttacg ataacgtagt 164100
cgatttaatt aaagactttg ttgaagttcg taaaacttat gtccaaaaac gaattgataa 164160
caaaatcaaa gaaactgagt cagcttttcg tttagccttt gccaaggcac atttcattaa 164220
gaaagtaatt tcaggtgaaa tcgttgtgca gggtaaaacc cgtaaagaac tgaccgaaga 164280
actttctaaa attgatatgt attcttctta tgttgataaa ctagttggaa tgaatatttt 164340
tcatatgact tccgacgaag caaagaaact tgctgaagaa gctaaagcta agaaagaaga 164400
aaacgaatat tggaaaacta ctgatgtagt tacagaatac accaaagatt tagaggaaat 164460
caaatgagtc cattcattgg tatcacaagc gctgcattag tatctggtgg cattttactg 164520
gcgggtttag gtgttgttcc tgccgtagca ggaggtcttc ttgcgttcgg aattcaacgt 164580
gttatcatga cagttatcac agtcatgcag taattttagg gagagccgag gctctccctt 164640
ttttatttaa aaatttttca caaaacggtt tacaaccaaa gcatactgtg gtactataca 164700
actatcaact actgatacag aattacggag attagaaaat gtctaaagta acttacatca 164760
tcaaagcttc taacgatgtt ctgaatgaaa aaactgctgc gattttaatt accattgcta 164820
agaaagattt cattacagct gcagaagttc gtgaggtgca tccagattta ggtaacgcag 164880
tagttaatag taatattggg gtattgatta aaaaaggcct ggtggagaaa tctggtgatg 164940
gattaatcat tactggtgaa gctcaggata ttatttcaaa tgcagcaact ttatatgcac 165000
aagaaaatgc tccggaacta ctgaaaaaac gagcaactcg taaagctcgc gagattactt 165060
ctgatatgga agaagataaa gacttcatgt taaaactttt agatgaaaat ggatttgttc 165120
ttaaaaaggt tgaaacttat cgtagtaatt atcttgccat tttagaaaaa cgcactcacg 165180
gaattcgtaa ttttgaaatt aacaataatg gaaatatgcg aatttttgga tacaaaatga 165240
tggaacatca tattcagaaa tttactgata tcggaatgtc atgtaaaatc gctaaaaacg 165300
gtaatgtgta tcttgacatt aaacgctcgg cagaaaacat tgaagctgta atcactgtag 165360
catctgaact gtgaggaata aataatgaac aagttagaaa ttgtcaatga acttcgtcgt 165420
tgtgtagaac ctactcaaga gggttgggac atctggtacc atggagctta tcttggaact 165480
attgtaaaga ttaagactgg caaatacatg attattcgtg aaagtaaaga tgctccagta 165540
ggtattcgca ataatttcat ggcagcgata agttcattta cggatgcagc ttacgaaatt 165600
taccttgctg attataaaga attccaggaa tctcaaccag ttattcgctc aattggtgtt 165660
aacaaagctc aacagaaaac tttgtggcaa cgtattaaag gatggtttaa atgaatccat 165720
ttattaatcg tttaaaaatg ctgaatgttc ctttatctcg tgaaactcca gaaagtcttg 165780
ttgaaaaatt taaagcacat ggttataaat gcacagaaga agatattctt gcggaagttc 165840
ctgaaatttg ttggcagtct gcatattggg acgaaaacca aaagtatcaa cgacgaattg 165900
tttgcgcagc caaccgtttt aaattaaaag atggacgaat tcttgttatt ccaggtgctc 165960
gtcattattc taaagatatg gccgaagttt tagatgtagt taaaccccaa ttagttactc 166020
agcaagtttg tgatgatgac caagggttta ttgaccaata tagtaattat tggacacgtg 166080
aagaagcaat gattattgca acttacgctg gacaagtacg tattgaacgt ggtggtagtg 166140
aaaaagaact ttactctgag gacctttact aatgaatatt aaacagtttc aaattgatgg 166200
aattatgaat caaatccagg cgctggaata tgctaataaa atgatgtcaa ccaaatgggg 166260
aatttatgcc aatgaaccgg catttcagtt ctgtaatatg gaattcacta aaaagctcgt 166320
aggaaaagat tatgtgtgcc catttagttc tccagtaaat ggaatgctaa aacctgcttt 166380
acgcgatctt tatattgcga tgaacgaaga aatgataaaa gaattaaaac gtcaactgaa 166440
ggtgattcaa tttggccagg gaaattaatt caaaatctga ttattttaat tctctcaatg 166500
ataaagataa aaatctaata cggcatttta ttgttgagat gggatatacc gatacacgcg 166560
atttaagaga acatatattt gaatgtggtg tagctaaaaa gttttcattc acatgcaaat 166620
gtttgagaga ggtaattcag cactatgaac aatttagtcg caaagcataa ttttaataaa 166680
gcttctgttc ataaagataa gaagaaagcg tttaaagaat ctaatcgcaa acagaaacat 166740
aaggggaagg tctatgatta ttgattctca atctgtggtt caatatacaa tcaaaattga 166800
cattctagaa aagctatata agtttctacc aaacctatac cattcaattg ttaatgaatt 166860
agttgaagaa ctacatcttg agaataatga tttcttggtt ggaacttata aagataactc 166920
aaaggcggga tatttttacg taattccagc tccaggaaaa agtattgatg atgtattaaa 166980
aactataatg ttttatgtcc atgattacga aattgaagat tatttcgaat gagtcataat 167040
cttgaaatgg taatcgagca taatgtagct caggaacgtg agtcgttcaa ggaattcgta 167100
gaaaaaattt ttgaagaaaa taacacagac cagtttacaa atcaagtgtc tgatgatatt 167160
ataataaagt caactaattg agtggtatag ttaatgaata aaaacattga tacagttcgt 167220
gaaattatta ctgttgcgtc tattttaatt aaattttcca gagaagatat tgttgaaaat 167280
cgtgctaatt ttattgcatt tctgaatgag attggagtaa cgcatgaagg tagaaaatta 167340
aatcagaatt cattccgtaa aatcgtttct gaattaactc aagaagataa gaaaaccctc 167400
atcgacgaat tcaacgaggg ttttgagggt gtatatcgat atctagagat gtatacgaac 167460
aaataattat ttagcccttc ctaatattct ggccgcctga gcacatattg attcaaggcg 167520
gtcattactt atatgatcat ttctatacca gtacatggtt attgttccag catagatatt 167580
atccaaattg aaatatggac aactgtacat gtagtttatt tcgggagtag gctttttagt 167640
tggtaaaaaa gcaaattttg agttggaata ataatgacgt ccatttaaat gaactgtata 167700
ttcatccata gttttatcga caggatatcc tccaagtgat ttttcactta ttgttgaagg 167760
taattttcct tcatatgcta taatatcaac aaaatagttt aagtttttag ggcggaaaga 167820
atacaccgca ctaaagtctg cctcagatga tatatgaact atctggagtt gttccagggc 167880
gacagattca aagcgtgcag ttctttcctt ttcaataatt tcactgtatg tttcatactt 167940
tgattgctta tagtactcaa agaaactatc tcccctatac caaacaatcg ccatcataaa 168000
taaaagaatt acgacagcta cccgggaagc aagaactttc ccggtagcgt tatctttgaa 168060
caagcgatct agaacaccca acagaatatc agagggcgaa aatgatattc taggtgctgc 168120
catagaccct ccttttaagg atatttattc aaattatact cttggaccat atattgctcc 168180
aacatttatc cacgttggag cagaccctat gacggcataa ccagcagctc cgccattatg 168240
ttcaggtcct tgaccacgaa cattacatct acctcctgcg gagccaacat caccaccgcc 168300
accaccgtta tagacaccat tcacggatcc tgagccaggt gcagaaatag taccgccagt 168360
cgcgcctgat tgcatattag cagacccacc agca 168394
Claims (9)
- 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 및 대장균(Escherichia coli)으로 이루어진 장내세균으로부터 선택되는 어느 하나 이상의 균에 대해 특이적인 증식 억제 또는 사멸능을 갖고, 서열번호 1의 염기서열로 구성되는 유전체를 갖는 박테리오파지.
- 제1항에 있어서,
상기 박테리오파지는 수탁번호 KCTC 13148BP로 기탁된 것을 특징으로 하는 박테리오파지. - 제1항에 있어서,
상기 여시니아(Yersinia)속 균주는 여시니아 엔테로콜리티카(Yersinia enterocolitica)이고, 상기 시겔라(Shigella)속 균주는 시겔라 손네이(Shigella sonnei)인 것을 특징으로 하는 박테리오파지. - 제1항의 박테리오파지를 유효성분으로 함유하는, 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 및 대장균(Escherichia coli)으로 이루어진 장내세균으로부터 선택되는 어느 하나 이상의 균에 대한 증식 억제 또는 사멸용 조성물.
- 제1항의 박테리오파지를 유효성분으로 함유하는, 여시니아(Yersinia)속 균주, 시겔라(Shigella)속 균주 및 대장균(Escherichia coli)으로 이루어진 장내세균으로부터 선택되는 어느 하나 이상의 균에 의해 유발되는 질환의 예방 또는 치료용 약학적 조성물.
- 제5항에 있어서,
상기 질환은 위장염, 관절염, 패혈증, 결핵성 홍반, 균혈증(Bacteremia), 가금티푸스, 장염, 설사, 및 복통 또는 발열을 동반하는 식중독 질환으로 이루어진 군으로부터 선택되는 어느 하나 이상의 질환인 것을 특징으로 하는 조성물. - 제1항의 박테리오파지를 유효성분으로 함유하는 항생제.
- 제1항의 박테리오파지를 유효성분으로 함유하는 소독제.
- 제1항의 박테리오파지를 유효성분으로 함유하는 항균용 사료 첨가제.
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Citations (3)
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|---|---|---|---|---|
| KR20100116289A (ko) | 2009-04-22 | 2010-11-01 | 경북대학교 산학협력단 | 병원성 장내세균을 사멸시키는 박테리오파지 |
| KR20110041670A (ko) * | 2009-10-16 | 2011-04-22 | 경희대학교 산학협력단 | 대장균 또는 시겔라속 균에 특이적 사멸능을 갖는 박테리오파지 |
| KR20110041698A (ko) * | 2009-10-16 | 2011-04-22 | 경희대학교 산학협력단 | 이질균에 특이적 사멸능을 갖는 박테리오파지 |
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| KR20100116289A (ko) | 2009-04-22 | 2010-11-01 | 경북대학교 산학협력단 | 병원성 장내세균을 사멸시키는 박테리오파지 |
| KR20110041670A (ko) * | 2009-10-16 | 2011-04-22 | 경희대학교 산학협력단 | 대장균 또는 시겔라속 균에 특이적 사멸능을 갖는 박테리오파지 |
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