KR20180122406A - 피리미딘 및 그의 변이체, 및 그의 용도 - Google Patents

피리미딘 및 그의 변이체, 및 그의 용도 Download PDF

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KR20180122406A
KR20180122406A KR1020187029170A KR20187029170A KR20180122406A KR 20180122406 A KR20180122406 A KR 20180122406A KR 1020187029170 A KR1020187029170 A KR 1020187029170A KR 20187029170 A KR20187029170 A KR 20187029170A KR 20180122406 A KR20180122406 A KR 20180122406A
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South Korea
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compound
alkyl
formula
hydrogen
mmol
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Korean (ko)
Inventor
로널드 찰스 홀리
프라바 이브라힘
안토니 피. 포드
조엘 알. 게버
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애퍼런트 파마슈티컬스 인크.
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Priority to KR1020217038082A priority Critical patent/KR102489454B1/ko
Publication of KR20180122406A publication Critical patent/KR20180122406A/ko
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    • C—CHEMISTRY; METALLURGY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
KR1020187029170A 2016-03-14 2017-03-09 피리미딘 및 그의 변이체, 및 그의 용도 Ceased KR20180122406A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217038082A KR102489454B1 (ko) 2016-03-14 2017-03-09 피리미딘 및 그의 변이체, 및 그의 용도

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662308157P 2016-03-14 2016-03-14
US62/308,157 2016-03-14
US201662363630P 2016-07-18 2016-07-18
US62/363,630 2016-07-18
PCT/US2017/021477 WO2017160569A1 (en) 2016-03-14 2017-03-09 Pyrimidines and variants thereof, and uses therefor

Related Child Applications (1)

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KR1020217038082A Division KR102489454B1 (ko) 2016-03-14 2017-03-09 피리미딘 및 그의 변이체, 및 그의 용도

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KR20180122406A true KR20180122406A (ko) 2018-11-12

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KR1020217038082A Active KR102489454B1 (ko) 2016-03-14 2017-03-09 피리미딘 및 그의 변이체, 및 그의 용도

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Country Link
US (1) US10822311B2 (enExample)
EP (1) EP3430000B1 (enExample)
JP (1) JP6968810B2 (enExample)
KR (2) KR20180122406A (enExample)
CN (1) CN108834412B (enExample)
AU (1) AU2017233841B9 (enExample)
MA (1) MA43821A (enExample)
MX (1) MX390482B (enExample)
RU (1) RU2761439C2 (enExample)
WO (1) WO2017160569A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180128015A (ko) * 2016-03-25 2018-11-30 애퍼런트 파마슈티컬스 인크. 피리미딘 및 그의 변이체, 및 그의 용도
KR20220008285A (ko) * 2019-04-30 2022-01-20 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 디아미노피리미딘 화합물의 염, 이의 고체, 이의 제조 방법 및 이의 용도

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10822311B2 (en) 2016-03-14 2020-11-03 Afferent Pharmaceuticals, Inc. Pyrimidines and variants thereof, and uses therefor
MX381790B (es) * 2016-12-20 2025-03-13 Afferent Pharmaceuticals Inc Sales cristalinas y polimorfos de un antagonista de p2x3.
JP7664680B2 (ja) 2017-03-29 2025-04-18 リガケム バイオサイエンシズ， インク． ピロロベンゾジアゼピン二量体前駆体及びそのリガンド－リンカーコンジュゲート化合物
CN107540699A (zh) * 2017-10-16 2018-01-05 康化（上海）新药研发有限公司 一种2‑氨基‑3‑氟吡啶‑4‑硼酸盐酸盐的合成方法
AU2019335070A1 (en) * 2018-09-06 2021-05-13 Ian Cooke Method of treating a sleep breathing disorder
IL282087B2 (en) * 2018-10-10 2025-11-01 Bellus Health Cough Inc 4-(imidazo[1,2-a]pyridin-3-yl)-benzamide derivatives for treating pruritus
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