KR20180095094A - 암을 치료하기 위한 방법 및 치료요법에 대한 임상 감수성의 예측변수로서 바이오마커의 용도 - Google Patents

암을 치료하기 위한 방법 및 치료요법에 대한 임상 감수성의 예측변수로서 바이오마커의 용도 Download PDF

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KR20180095094A
KR20180095094A KR1020187022882A KR20187022882A KR20180095094A KR 20180095094 A KR20180095094 A KR 20180095094A KR 1020187022882 A KR1020187022882 A KR 1020187022882A KR 20187022882 A KR20187022882 A KR 20187022882A KR 20180095094 A KR20180095094 A KR 20180095094A
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biomarker
compound
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엘렌 필바로프
안토니아 로페스-히로나
강 루
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셀진 코포레이션
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KR1020187022882A 2016-01-08 2017-01-06 암을 치료하기 위한 방법 및 치료요법에 대한 임상 감수성의 예측변수로서 바이오마커의 용도 Ceased KR20180095094A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662276700P 2016-01-08 2016-01-08
US62/276,700 2016-01-08
US201662404638P 2016-10-05 2016-10-05
US62/404,638 2016-10-05
PCT/US2017/012496 WO2017120446A1 (en) 2016-01-08 2017-01-06 Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies

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US (3) US10648983B2 (cg-RX-API-DMAC7.html)
EP (1) EP3399980B1 (cg-RX-API-DMAC7.html)
JP (3) JP6880037B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180095094A (cg-RX-API-DMAC7.html)
AU (1) AU2017205170B2 (cg-RX-API-DMAC7.html)
CA (1) CA3010801A1 (cg-RX-API-DMAC7.html)
ES (1) ES3042541T3 (cg-RX-API-DMAC7.html)
IL (2) IL296659A (cg-RX-API-DMAC7.html)
MX (1) MX390772B (cg-RX-API-DMAC7.html)
WO (1) WO2017120446A1 (cg-RX-API-DMAC7.html)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210111938A (ko) * 2020-03-03 2021-09-14 이화여자대학교 산학협력단 교모세포종 예후예측용 조성물
KR20220080003A (ko) * 2020-09-23 2022-06-14 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 세레브론 단백질의 조절제로서의 치환된 n-(2-(2,6-디옥소피페리딘-3-일)-1,3-디옥소이소인돌린-5-일)아릴설폰아미드 유사체
WO2022208107A1 (en) * 2021-03-31 2022-10-06 Imperial College Innovations Limited Methods and compositions for identifying and treating gcn2-dependent cancers
KR20230068335A (ko) 2021-11-09 2023-05-17 한국화학연구원 글루타이미드 모핵을 갖는 이소인돌리논 유도체 및 이의 용도
WO2023085785A1 (ko) 2021-11-09 2023-05-19 한국화학연구원 글루타이미드 모핵을 갖는 이소인돌리논 유도체 및 이의 용도
WO2024101763A1 (ko) 2022-11-08 2024-05-16 주식회사 온코드바이오 아릴시클로알킬아마이드 구조를 갖는 이소인돌리논 유도체 및 이의 용도
WO2024101764A1 (ko) 2022-11-08 2024-05-16 주식회사 온코드바이오 퀴놀린 아마이드 구조를 갖는 이소인돌리논 유도체 및 이의 용도
WO2024215130A1 (en) * 2023-04-13 2024-10-17 Cyrus Therapeutics Inc. Novel gspt1 degrader and use thereof
WO2025164957A1 (ko) * 2024-01-31 2025-08-07 남부대학교산학협력단 인간화된 세레브론 넉인 마우스 모델 및 이를 이용한 다발성 골수종 항암화학요법의 효능 평가 방법

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015085172A2 (en) 2013-12-06 2015-06-11 Celgene Corporation Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers
US10338077B2 (en) 2015-06-02 2019-07-02 Celgene Corporation Methods for determining drug efficacy for treatment of cancer ration of cereblon associated proteins
AU2016326499A1 (en) 2015-09-25 2018-04-12 Celgene Corporation Methods for treating diffuse large B-cell lymphoma and the use of biomarkers as a predictor of responsiveness to drugs
ES3042541T3 (en) 2016-01-08 2025-11-21 Celgene Corp Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies
US11525165B2 (en) 2017-12-20 2022-12-13 Inserm Method of selection of an IRE1-inhibitor therapy for patient suffering from cancer
WO2019191451A1 (en) * 2018-03-30 2019-10-03 Biotheryx, Inc. Thienopyrimidinone compounds
WO2019226770A1 (en) * 2018-05-23 2019-11-28 Celgene Corporation Treating multiple myeloma and the use of biomarkers for 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1- oxoisoindolin-4-yl)oxy)methyl)benzyl) piperazin-1-yl)-3-fluorobenzonitrile
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CA3150653A1 (en) * 2019-09-12 2021-03-18 Yunfu Luo FUSED CYCLIC COMPOUND CAPABLE OF DEGRADING A PROTEIN AND ITS USE
MX2022004984A (es) * 2019-10-28 2022-05-13 Celgene Corp Metodos para tratar leucemia y uso de una firma de celulas madre leucemicas para predecir sensibilidad clinica a terapias.
MX2022005159A (es) * 2019-10-28 2022-06-08 Celgene Corp Uso de biomarcadores para predecir la sensibilidad clinica a 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin- 5-il)metil)-2,2-difluoroacetamida.
US11031119B2 (en) * 2019-11-13 2021-06-08 Cube Click, Inc. Dental images processed with deep learning for national security
WO2021113566A1 (en) * 2019-12-06 2021-06-10 Celgene Corporation Processes for preparing 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
CA3171588A1 (en) * 2020-03-16 2021-09-23 Celgene Corporation Combination therapy for acute myeloid leukemia
WO2021211742A1 (en) * 2020-04-14 2021-10-21 The General Hospital Corporation Use of gcn2 inhibitors in treating mitochondrial myopathies and diseases associated with mitochondrial dysfunction
WO2021260111A1 (en) 2020-06-25 2021-12-30 Tolremo Therapeutics Ag Combination of a cbp/p300 bromodomain inhibitor and a kras inhibitor for the treatment of cancer
US20240261274A1 (en) * 2021-01-13 2024-08-08 Monte Rosa Therapeutics, Inc. Treatment of myc-driven cancers with gspt1 degraders
EP4277901A1 (en) 2021-01-13 2023-11-22 Monte Rosa Therapeutics, Inc. Isoindolinone compounds
AR125312A1 (es) * 2021-04-07 2023-07-05 Tolremo Therapeutics Ag Derivados heterocíclicos, composiciones farmacéuticas y su uso en el tratamiento o la mejora del cáncer
WO2022219412A1 (en) * 2021-04-14 2022-10-20 Monte Rosa Therapeutics Ag Isoindolinone amide compounds useful to treat diseases associated with gspt1
CN114660289A (zh) * 2022-03-03 2022-06-24 中山大学附属第三医院 肝癌标志物及其应用
AU2023252917A1 (en) * 2022-04-14 2024-11-28 Bristol-Myers Squibb Company Novel gspt1 compounds and methods of use of the novel compounds
US20240115557A1 (en) * 2022-07-29 2024-04-11 The Brigham And Women's Hospital, Inc. Inhibitors of rna-guided nucleases and uses thereof
KR20250075597A (ko) * 2022-09-16 2025-05-28 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 심장 아밀로이드증의 치료를 위한 bag3 방법 및 용도

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1574740A (en) * 1924-04-07 1926-02-23 Raynor John Roscoe Cutting device
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
HU196714B (en) 1984-10-04 1989-01-30 Monsanto Co Process for producing non-aqueous composition comprising somatotropin
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
PH30995A (en) 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
EP0631635B1 (en) 1992-03-04 2001-09-12 The Regents Of The University Of California Comparative genomic hybridization (cgh)
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
TW333456B (en) 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US6087324A (en) 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
ATE268591T1 (de) 1995-06-27 2004-06-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von zubereitungen mit verzögerter freisetzung
TW448055B (en) 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
JP2909418B2 (ja) 1995-09-18 1999-06-23 株式会社資生堂 薬物の遅延放出型マイクロスフイア
US5980945A (en) 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
US6264970B1 (en) 1996-06-26 2001-07-24 Takeda Chemical Industries, Ltd. Sustained-release preparation
CA2217134A1 (en) 1996-10-09 1998-04-09 Sumitomo Pharmaceuticals Co., Ltd. Sustained release formulation
ES2221019T3 (es) 1996-10-31 2004-12-16 Takeda Chemical Industries, Ltd. Preparacion de liberacion mantenida.
DE69719367T2 (de) 1996-12-20 2003-10-16 Takeda Chemical Industries, Ltd. Verfahren zur herstellung einer zusammensetzung mit verzoegerter abgabe
US5891474A (en) 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
GB0103527D0 (en) 2001-02-13 2001-03-28 Eastman Kodak Co Photographic developing composition and use thereof in the development of a photographic element
US7122799B2 (en) 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
EP1888784A2 (en) * 2005-05-18 2008-02-20 Wyeth a Corporation of the State of Delaware Leukemia disease genes and uses thereof
HUE026105T2 (en) * 2008-10-29 2016-05-30 Celgene Corp Isoindole compounds for use in the treatment of cancer
EP2544687A1 (en) * 2010-03-12 2013-01-16 Celgene Corporation Methods for the treatment of non-hodgkin's lymphomas using lenalidomide, and gene and protein biomarkers as a predictor
US9090585B2 (en) 2011-03-28 2015-07-28 Deuterx, Llc 2,6-dioxo-3-deutero-piperdin-3-yl-isoindoline compounds
WO2012149299A2 (en) 2011-04-29 2012-11-01 Celgene Corporaiton Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
EP3904875B1 (en) 2012-06-29 2024-11-20 Celgene Corporation Methods for determining drug efficacy using ikzf3 (aiolos)
JP2016521280A (ja) * 2013-05-03 2016-07-21 セルジーン コーポレイション 併用療法を用いて癌を治療する方法
WO2015085172A2 (en) 2013-12-06 2015-06-11 Celgene Corporation Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers
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US9499514B2 (en) * 2014-07-11 2016-11-22 Celgene Corporation Antiproliferative compounds and methods of use thereof
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US10338077B2 (en) 2015-06-02 2019-07-02 Celgene Corporation Methods for determining drug efficacy for treatment of cancer ration of cereblon associated proteins
JP2018523823A (ja) 2015-08-04 2018-08-23 セルジーン コーポレイション 慢性リンパ球性白血病の治療方法及び免疫調節療法に対する臨床的感度の予測因子としてのバイオマーカーの利用
EP3334844A4 (en) 2015-08-12 2019-11-06 Celgene Corporation METHOD FOR THE TREATMENT OF SOLID TUMORS AND USE OF BIOMARKERS AS PREDICTORS OF CLINICAL SENSITIVITY TO IMMUNOMODULATORY THERAPIES
AU2016326499A1 (en) 2015-09-25 2018-04-12 Celgene Corporation Methods for treating diffuse large B-cell lymphoma and the use of biomarkers as a predictor of responsiveness to drugs
KR20180100565A (ko) * 2016-01-08 2018-09-11 셀진 코포레이션 2-(4-클로로페닐)-n-((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-5-일)메틸)-2,2-디플루오로아세트아미드의 제형
ES3042541T3 (en) 2016-01-08 2025-11-21 Celgene Corp Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies
MX385964B (es) * 2016-01-08 2025-03-18 Celgene Corp Formas sólidas de 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il) metil)-2,2-difluoroacetamida y sus composiciones farmacéuticas y usos.
SG11201809501PA (en) * 2016-06-06 2018-12-28 Celgene Corp Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

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US12454519B2 (en) 2020-09-23 2025-10-28 St. Jude Children's Research Hospital, Inc. Substituted N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs as modulators of cereblon protein
KR20220080003A (ko) * 2020-09-23 2022-06-14 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 세레브론 단백질의 조절제로서의 치환된 n-(2-(2,6-디옥소피페리딘-3-일)-1,3-디옥소이소인돌린-5-일)아릴설폰아미드 유사체
US12454518B2 (en) 2020-09-23 2025-10-28 St. Jude Children's Research Hospital, Inc. Substituted N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs as modulators of cereblon protein
WO2022208107A1 (en) * 2021-03-31 2022-10-06 Imperial College Innovations Limited Methods and compositions for identifying and treating gcn2-dependent cancers
KR20230068335A (ko) 2021-11-09 2023-05-17 한국화학연구원 글루타이미드 모핵을 갖는 이소인돌리논 유도체 및 이의 용도
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EP4617270A1 (en) 2022-11-08 2025-09-17 Oncord Bio Inc Isoindolinone derivative having quinoline amide structure, and use thereof
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WO2024215130A1 (en) * 2023-04-13 2024-10-17 Cyrus Therapeutics Inc. Novel gspt1 degrader and use thereof
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