KR20180094989A - 노화 관련 인지장애 및 신경염증의 예방 및/또는 치료 방법 - Google Patents

노화 관련 인지장애 및 신경염증의 예방 및/또는 치료 방법 Download PDF

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Publication number
KR20180094989A
KR20180094989A KR1020187020017A KR20187020017A KR20180094989A KR 20180094989 A KR20180094989 A KR 20180094989A KR 1020187020017 A KR1020187020017 A KR 1020187020017A KR 20187020017 A KR20187020017 A KR 20187020017A KR 20180094989 A KR20180094989 A KR 20180094989A
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aging
animals
subject
zln005
neuroinflammation
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KR1020187020017A
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English (en)
Korean (ko)
Inventor
코아 딘 느구옌
에드가 지. 엥글레만
Original Assignee
더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티
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Publication of KR20180094989A publication Critical patent/KR20180094989A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020187020017A 2015-12-15 2016-12-09 노화 관련 인지장애 및 신경염증의 예방 및/또는 치료 방법 Ceased KR20180094989A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562267437P 2015-12-15 2015-12-15
US62/267,437 2015-12-15
PCT/US2016/065972 WO2017106050A1 (en) 2015-12-15 2016-12-09 Method for preventing and/or treating aging-associated cognitive impairment and neuroinflammation

Publications (1)

Publication Number Publication Date
KR20180094989A true KR20180094989A (ko) 2018-08-24

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KR1020187020017A Ceased KR20180094989A (ko) 2015-12-15 2016-12-09 노화 관련 인지장애 및 신경염증의 예방 및/또는 치료 방법

Country Status (18)

Country Link
US (3) US10653669B2 (https=)
EP (2) EP3390367B1 (https=)
JP (1) JP6837486B2 (https=)
KR (1) KR20180094989A (https=)
CN (1) CN108884053B (https=)
AU (1) AU2016371598B2 (https=)
CA (1) CA3008019A1 (https=)
DK (1) DK3390367T3 (https=)
ES (1) ES2830447T3 (https=)
HR (1) HRP20201652T1 (https=)
HU (1) HUE051771T2 (https=)
IL (2) IL285248B2 (https=)
MX (1) MX379086B (https=)
PL (1) PL3390367T3 (https=)
PT (1) PT3390367T (https=)
RS (1) RS61053B1 (https=)
SM (1) SMT202000601T1 (https=)
WO (1) WO2017106050A1 (https=)

Families Citing this family (11)

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CA3000985C (en) 2014-10-14 2023-01-31 The Board Of Trustees Of The Leland Stanford Junior University Method for treating neurodegenerative diseases
AU2016371598B2 (en) * 2015-12-15 2021-05-13 The Board Of Trustees Of The Leland Stanford Junior University Method for preventing and/or treating aging-associated cognitive impairment and neuroinflammation
KR20210068399A (ko) * 2018-08-06 2021-06-09 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티 신경퇴행성 질병의 치료를 위한 피피에이알지씨1알파 활성제로서 2-아릴벤즈이미다졸
US20240316008A1 (en) 2020-06-22 2024-09-26 Tranquis Therapeutics, Inc. Treatment of systemic immune activation syndromes
CN112933232A (zh) * 2021-02-02 2021-06-11 袁玉佳 PGC-1α激活TFEB介导的自噬在制备治疗急性肾损伤的药物中的应用
WO2022266455A1 (en) * 2021-06-17 2022-12-22 Tranquis Therapeutics, Inc. Therapeutically effective oral administration of a 2 arylbenzimidazole
EP4426295A1 (en) 2021-11-02 2024-09-11 Tranquis Therapeutics, Inc. Selection and treatment of subjects having a circulating myeloid cell inflammatory phenotype
TW202415372A (zh) 2022-06-14 2024-04-16 美商特朗奎斯治療股份有限公司 老化相關改變及疾病之治療
TW202416960A (zh) 2022-06-17 2024-05-01 美商特朗奎斯治療股份有限公司 2-芳基苯并咪唑化合物之調配物
KR20250144994A (ko) * 2022-11-18 2025-10-13 사토시 고조 Zln-005 및 관련 화합물의 용도
WO2024118936A1 (en) 2022-12-02 2024-06-06 Tranquis Therapeutics, Inc. 2-arylbenzimidazole compounds for the treatment of hemoglobinopathies

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CA3000985C (en) * 2014-10-14 2023-01-31 The Board Of Trustees Of The Leland Stanford Junior University Method for treating neurodegenerative diseases
CN104873500A (zh) * 2015-04-29 2015-09-02 中国人民解放军第四军医大学 化合物zln005的用途
JP7134089B2 (ja) * 2015-05-18 2022-09-09 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 老化に関連した障害を処置するための方法及び組成物
AU2016371598B2 (en) * 2015-12-15 2021-05-13 The Board Of Trustees Of The Leland Stanford Junior University Method for preventing and/or treating aging-associated cognitive impairment and neuroinflammation
US20240316008A1 (en) * 2020-06-22 2024-09-26 Tranquis Therapeutics, Inc. Treatment of systemic immune activation syndromes

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Publication number Publication date
CN108884053B (zh) 2022-01-04
US10653669B2 (en) 2020-05-19
AU2016371598B2 (en) 2021-05-13
EP3390367A1 (en) 2018-10-24
EP3390367B1 (en) 2020-09-09
CN108884053A (zh) 2018-11-23
IL259902B (en) 2021-08-31
SMT202000601T1 (it) 2021-01-05
ES2830447T3 (es) 2021-06-03
MX2018007147A (es) 2019-03-28
HK1261918A1 (en) 2020-01-10
EP3390367A4 (en) 2019-08-07
EP3741747A1 (en) 2020-11-25
PT3390367T (pt) 2020-09-23
DK3390367T3 (da) 2020-10-26
RS61053B1 (sr) 2020-12-31
US20240245646A1 (en) 2024-07-25
IL285248B2 (en) 2025-10-01
JP2018537507A (ja) 2018-12-20
BR112018012195A2 (pt) 2018-12-18
IL259902A (en) 2018-07-31
CA3008019A1 (en) 2017-06-22
WO2017106050A1 (en) 2017-06-22
US20180353474A1 (en) 2018-12-13
HUE051771T2 (hu) 2021-03-29
EP3741747C0 (en) 2024-10-16
IL285248B1 (en) 2025-06-01
MX379086B (es) 2025-03-10
JP6837486B2 (ja) 2021-03-03
IL285248A (en) 2021-09-30
EP3741747B1 (en) 2024-10-16
HRP20201652T1 (hr) 2020-12-25
US20210059985A1 (en) 2021-03-04
PL3390367T3 (pl) 2021-03-08
AU2016371598A1 (en) 2018-07-12

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