KR20180094989A - 노화 관련 인지장애 및 신경염증의 예방 및/또는 치료 방법 - Google Patents

노화 관련 인지장애 및 신경염증의 예방 및/또는 치료 방법 Download PDF

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Publication number
KR20180094989A
KR20180094989A KR1020187020017A KR20187020017A KR20180094989A KR 20180094989 A KR20180094989 A KR 20180094989A KR 1020187020017 A KR1020187020017 A KR 1020187020017A KR 20187020017 A KR20187020017 A KR 20187020017A KR 20180094989 A KR20180094989 A KR 20180094989A
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aging
animals
subject
zln005
neuroinflammation
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KR1020187020017A
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English (en)
Korean (ko)
Inventor
코아 딘 느구옌
에드가 지. 엥글레만
Original Assignee
더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티
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Application filed by 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티 filed Critical 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티
Publication of KR20180094989A publication Critical patent/KR20180094989A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020187020017A 2015-12-15 2016-12-09 노화 관련 인지장애 및 신경염증의 예방 및/또는 치료 방법 Ceased KR20180094989A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562267437P 2015-12-15 2015-12-15
US62/267,437 2015-12-15
PCT/US2016/065972 WO2017106050A1 (en) 2015-12-15 2016-12-09 Method for preventing and/or treating aging-associated cognitive impairment and neuroinflammation

Publications (1)

Publication Number Publication Date
KR20180094989A true KR20180094989A (ko) 2018-08-24

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KR1020187020017A Ceased KR20180094989A (ko) 2015-12-15 2016-12-09 노화 관련 인지장애 및 신경염증의 예방 및/또는 치료 방법

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US (3) US10653669B2 (enExample)
EP (2) EP3390367B1 (enExample)
JP (1) JP6837486B2 (enExample)
KR (1) KR20180094989A (enExample)
CN (1) CN108884053B (enExample)
AU (1) AU2016371598B2 (enExample)
CA (1) CA3008019A1 (enExample)
DK (1) DK3390367T3 (enExample)
ES (1) ES2830447T3 (enExample)
HR (1) HRP20201652T1 (enExample)
HU (1) HUE051771T2 (enExample)
IL (2) IL285248B2 (enExample)
MX (1) MX379086B (enExample)
PL (1) PL3390367T3 (enExample)
PT (1) PT3390367T (enExample)
RS (1) RS61053B1 (enExample)
SM (1) SMT202000601T1 (enExample)
WO (1) WO2017106050A1 (enExample)

Families Citing this family (11)

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WO2016061190A1 (en) 2014-10-14 2016-04-21 The Board Of Trustees Of The Leland Stanford Junior University Method for treating neurodegenerative diseases
CN108884053B (zh) * 2015-12-15 2022-01-04 斯坦福大学托管董事会 预防和/或治疗与衰老有关的认知障碍和神经炎症的方法
EP3833344A4 (en) 2018-08-06 2022-07-06 The Board of Trustees of the Leland Stanford Junior University 2-ARYLBENZIMIDAZOLES USEFUL AS PPARGC1A ACTIVATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
EP4171551A1 (en) 2020-06-22 2023-05-03 Tranquis Therapeutics, Inc. Treatment of systemic immune activation syndromes
CN112933232A (zh) * 2021-02-02 2021-06-11 袁玉佳 PGC-1α激活TFEB介导的自噬在制备治疗急性肾损伤的药物中的应用
JP2024522820A (ja) * 2021-06-17 2024-06-21 トランクイス セラピューティクス， インコーポレイテッド ２－アリールベンゾイミダゾールの治療上有効な経口投与
US20250009714A1 (en) 2021-11-02 2025-01-09 Tranquis Therapeutics, Inc. Selection and treatment of subjects having a circulating myeloid cell inflammatory phenotype
TW202415372A (zh) 2022-06-14 2024-04-16 美商特朗奎斯治療股份有限公司 老化相關改變及疾病之治療
TW202416960A (zh) 2022-06-17 2024-05-01 美商特朗奎斯治療股份有限公司 2-芳基苯并咪唑化合物之調配物
AU2023380184A1 (en) * 2022-11-18 2025-07-03 Satoshi Gojo Uses of zln-005 and related compounds
WO2024118936A1 (en) 2022-12-02 2024-06-06 Tranquis Therapeutics, Inc. 2-arylbenzimidazole compounds for the treatment of hemoglobinopathies

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DK1246808T3 (da) * 2000-01-14 2011-12-05 Bayer Pharma AG 1,2-diarylbenzimidazoler til behandling af sygdomme, som er associeret med en mikroglia-aktivering
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ES2830352T3 (es) * 2013-09-18 2021-06-03 Univ Georgetown Tratamiento de enfermedad neurodegenerativa con fenofibrato y análogos del mismo
WO2016061190A1 (en) * 2014-10-14 2016-04-21 The Board Of Trustees Of The Leland Stanford Junior University Method for treating neurodegenerative diseases
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CN108884053B (zh) * 2015-12-15 2022-01-04 斯坦福大学托管董事会 预防和/或治疗与衰老有关的认知障碍和神经炎症的方法
EP4171551A1 (en) * 2020-06-22 2023-05-03 Tranquis Therapeutics, Inc. Treatment of systemic immune activation syndromes

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JP2018537507A (ja) 2018-12-20
HUE051771T2 (hu) 2021-03-29
US10653669B2 (en) 2020-05-19
EP3390367A4 (en) 2019-08-07
DK3390367T3 (da) 2020-10-26
CN108884053B (zh) 2022-01-04
MX379086B (es) 2025-03-10
IL259902A (en) 2018-07-31
IL285248B2 (en) 2025-10-01
AU2016371598A1 (en) 2018-07-12
HK1261918A1 (en) 2020-01-10
HRP20201652T1 (hr) 2020-12-25
SMT202000601T1 (it) 2021-01-05
IL259902B (en) 2021-08-31
EP3741747C0 (en) 2024-10-16
RS61053B1 (sr) 2020-12-31
WO2017106050A1 (en) 2017-06-22
US20210059985A1 (en) 2021-03-04
EP3390367A1 (en) 2018-10-24
ES2830447T3 (es) 2021-06-03
CA3008019A1 (en) 2017-06-22
US20240245646A1 (en) 2024-07-25
IL285248B1 (en) 2025-06-01
BR112018012195A2 (pt) 2018-12-18
MX2018007147A (es) 2019-03-28
JP6837486B2 (ja) 2021-03-03
AU2016371598B2 (en) 2021-05-13
PL3390367T3 (pl) 2021-03-08
EP3741747B1 (en) 2024-10-16
IL285248A (en) 2021-09-30
US20180353474A1 (en) 2018-12-13
EP3741747A1 (en) 2020-11-25
CN108884053A (zh) 2018-11-23
EP3390367B1 (en) 2020-09-09
PT3390367T (pt) 2020-09-23

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