KR20180050331A - 증가된 안정성 및 개선된 흡수율을 갖는 호노키올 및 마그놀롤 제형, 및 이의 사용 방법 - Google Patents

증가된 안정성 및 개선된 흡수율을 갖는 호노키올 및 마그놀롤 제형, 및 이의 사용 방법 Download PDF

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Publication number
KR20180050331A
KR20180050331A KR1020187007412A KR20187007412A KR20180050331A KR 20180050331 A KR20180050331 A KR 20180050331A KR 1020187007412 A KR1020187007412 A KR 1020187007412A KR 20187007412 A KR20187007412 A KR 20187007412A KR 20180050331 A KR20180050331 A KR 20180050331A
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South Korea
Prior art keywords
formulation
magnolol
less
disorder
formulations
Prior art date
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Ceased
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KR1020187007412A
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English (en)
Korean (ko)
Inventor
보미 피. 프람로제
Original Assignee
에스티 아이피 홀딩 아게
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Publication of KR20180050331A publication Critical patent/KR20180050331A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Anesthesiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020187007412A 2015-08-17 2016-01-18 증가된 안정성 및 개선된 흡수율을 갖는 호노키올 및 마그놀롤 제형, 및 이의 사용 방법 Ceased KR20180050331A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2534DE2015 2015-08-17
IN2534/DEL/2015 2015-08-17
PCT/IN2016/050021 WO2017029683A1 (en) 2015-08-17 2016-01-18 Honokiol and magnolol formulations with increased stability and improved uptake, and methods of use thereof

Publications (1)

Publication Number Publication Date
KR20180050331A true KR20180050331A (ko) 2018-05-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187007412A Ceased KR20180050331A (ko) 2015-08-17 2016-01-18 증가된 안정성 및 개선된 흡수율을 갖는 호노키올 및 마그놀롤 제형, 및 이의 사용 방법

Country Status (12)

Country Link
US (1) US10328090B2 (enExample)
EP (1) EP3337487B1 (enExample)
JP (1) JP6663993B2 (enExample)
KR (1) KR20180050331A (enExample)
AU (2) AU2016308080A1 (enExample)
CA (1) CA2995834A1 (enExample)
DK (1) DK3337487T3 (enExample)
ES (1) ES2873601T3 (enExample)
HU (1) HUE054161T2 (enExample)
PL (1) PL3337487T3 (enExample)
PT (1) PT3337487T (enExample)
WO (1) WO2017029683A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110585140A (zh) * 2019-07-08 2019-12-20 苏州海特比奥生物技术有限公司 一种和厚朴酚纳米聚合物胶束冻干制剂及其制备方法
WO2020138974A1 (ko) * 2018-12-28 2020-07-02 충북대학교 산학협력단 일본 목련 추출물을 유효성분으로 함유하는 불안장애의 예방 또는 치료용 약학적 조성물

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019183141A1 (en) 2018-03-21 2019-09-26 Realtime Robotics, Inc. Motion planning of a robot for various environments and tasks and improved operation of same
WO2020154712A1 (en) * 2019-01-25 2020-07-30 Flaask, Llc Compositions and methods for improving quality of life in patients with autism spectrum disorder
US12213505B2 (en) * 2021-07-05 2025-02-04 Healthy Ingredient Solutions, LLC Composition for promoting restful sleep and methods of making and using the same
WO2025136962A1 (en) * 2023-12-19 2025-06-26 Rebalance Health, Inc. Compositions for reducing hot flashes and symptoms associated with anxiety and formulations thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582735B2 (en) 2000-12-15 2003-06-24 Npi, Llc. Compositions and methods of use for extracts of magnoliaceae plants
US7632525B2 (en) 2002-06-25 2009-12-15 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents
CN1723011A (zh) 2002-06-25 2006-01-18 Wm·雷格利Jr·公司 含有厚朴提取物的口气清新和口腔清洁产品
CN101321537A (zh) 2005-12-02 2008-12-10 Gic创新公司 含厚朴提取物的糖食组合物
RU2396941C2 (ru) 2005-12-02 2010-08-20 Джи Ай Си ИННОВАТИОНЗ КОМПАНИ Наполнители с экстрактом коры магнолии для ухода за полостью рта
RU2398593C2 (ru) 2005-12-02 2010-09-10 Джи Ай Си ИННОВАТИОНЗ КОМПАНИ Жевательные составы с экстрактом коры магнолии быстрого высвобождения
BRPI0810435A2 (pt) 2007-04-19 2014-11-25 Mary Kay Inc Composições contendo extrato de magnólia
WO2011115476A1 (en) * 2010-03-17 2011-09-22 N.V. Nutricia Infant nutrition for improving fatty acid composition of brain membranes later in life
DE102010015791A1 (de) * 2010-04-20 2011-10-20 Beiersdorf Ag Wirkstoffkombinationen aus Magnolienrindenextrakt und polyethoxylierten Verbindungen
DE102010015792A1 (de) * 2010-04-20 2011-10-20 Beiersdorf Ag Wirkstoffkombinationen aus Magnolienrindenextrakt und oberflächenaktiven Agentien
EP2611313A1 (en) * 2010-09-03 2013-07-10 N.V. Nutricia Method and preparation for the treatment or prevention of anxiety or neurogenesis
FR2970294B1 (fr) * 2011-01-11 2012-12-28 Peugeot Citroen Automobiles Sa Ligne d'echappement pour un moteur a combustion interne
IE20110008A1 (en) 2011-01-12 2012-08-01 Patrick Thomas Prendergast Compositions for alleviating:- stress, anxiety, depression and aiding with weight loss
WO2013043151A1 (en) 2011-09-19 2013-03-28 Framroze Bomi P Edible oil with a high concentration of poly-unsaturated fatty acids
CA2849294C (en) * 2011-09-20 2023-03-21 Vivaquant Llc Physiological signal denoising

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020138974A1 (ko) * 2018-12-28 2020-07-02 충북대학교 산학협력단 일본 목련 추출물을 유효성분으로 함유하는 불안장애의 예방 또는 치료용 약학적 조성물
CN110585140A (zh) * 2019-07-08 2019-12-20 苏州海特比奥生物技术有限公司 一种和厚朴酚纳米聚合物胶束冻干制剂及其制备方法

Also Published As

Publication number Publication date
PT3337487T (pt) 2021-05-27
WO2017029683A1 (en) 2017-02-23
US20180147220A1 (en) 2018-05-31
JP6663993B2 (ja) 2020-03-13
EP3337487B1 (en) 2021-02-24
EP3337487A4 (en) 2019-04-03
DK3337487T3 (da) 2021-05-25
JP2018528266A (ja) 2018-09-27
US10328090B2 (en) 2019-06-25
AU2016308080A1 (en) 2018-03-22
PL3337487T3 (pl) 2021-12-06
EP3337487A1 (en) 2018-06-27
ES2873601T3 (es) 2021-11-03
AU2022201271A1 (en) 2022-03-17
CA2995834A1 (en) 2017-02-23
HUE054161T2 (hu) 2021-08-30

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