KR20180049198A - 신규한 npr-b 길항제 - Google Patents

신규한 npr-b 길항제 Download PDF

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Publication number
KR20180049198A
KR20180049198A KR1020187012130A KR20187012130A KR20180049198A KR 20180049198 A KR20180049198 A KR 20180049198A KR 1020187012130 A KR1020187012130 A KR 1020187012130A KR 20187012130 A KR20187012130 A KR 20187012130A KR 20180049198 A KR20180049198 A KR 20180049198A
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South Korea
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leu
arg
phe
ala
seq
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KR1020187012130A
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Korean (ko)
Inventor
프랭크 오스터캄프
하이코 하프리쉬
게르트 후멀
토비아스 크나우테
울프 라이머
울리히 라이네케
우베 리히터
베르나데트 시몬
에드가르 스펙커
마르쿠스 보이쉬니크
마크 알. 헬버그
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샤이어 오펀 테라피즈 게엠베하
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43781057&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20180049198(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 샤이어 오펀 테라피즈 게엠베하 filed Critical 샤이어 오펀 테라피즈 게엠베하
Publication of KR20180049198A publication Critical patent/KR20180049198A/ko
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2242Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/58Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020187012130A 2009-09-25 2010-09-23 신규한 npr-b 길항제 Ceased KR20180049198A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24596009P 2009-09-25 2009-09-25
US61/245,960 2009-09-25
PCT/US2010/049912 WO2011038061A2 (en) 2009-09-25 2010-09-23 Novel npr-b agonists

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020177022310A Division KR101854820B1 (ko) 2009-09-25 2010-09-23 신규한 npr-b 길항제

Publications (1)

Publication Number Publication Date
KR20180049198A true KR20180049198A (ko) 2018-05-10

Family

ID=43781057

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020187012130A Ceased KR20180049198A (ko) 2009-09-25 2010-09-23 신규한 npr-b 길항제
KR1020177022310A Expired - Fee Related KR101854820B1 (ko) 2009-09-25 2010-09-23 신규한 npr-b 길항제
KR1020127010423A Expired - Fee Related KR101768661B1 (ko) 2009-09-25 2010-09-23 신규한 npr-b 길항제

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020177022310A Expired - Fee Related KR101854820B1 (ko) 2009-09-25 2010-09-23 신규한 npr-b 길항제
KR1020127010423A Expired - Fee Related KR101768661B1 (ko) 2009-09-25 2010-09-23 신규한 npr-b 길항제

Country Status (17)

Country Link
US (5) US8546523B2 (enExample)
EP (1) EP2480247B1 (enExample)
JP (3) JP5893561B2 (enExample)
KR (3) KR20180049198A (enExample)
CN (2) CN105732767A (enExample)
AR (1) AR078445A1 (enExample)
AU (1) AU2010298256B2 (enExample)
BR (1) BR112012006579A2 (enExample)
CA (1) CA2773949C (enExample)
CL (2) CL2012000715A1 (enExample)
MX (3) MX354005B (enExample)
PH (1) PH12012500562A1 (enExample)
RU (3) RU2557290C2 (enExample)
TW (2) TWI577384B (enExample)
UY (1) UY32902A (enExample)
WO (1) WO2011038061A2 (enExample)
ZA (3) ZA201201630B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102677730B1 (ko) * 2023-03-27 2024-06-27 나인바이오팜 주식회사 지방 분해 효능을 갖는 펩타이드 및 이의 용도

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2554713T3 (es) 2005-04-07 2015-12-22 Cardiorentis Ag Uso de un péptido natriurético para tratar insuficiencia cardiaca
RU2465893C2 (ru) * 2006-08-02 2012-11-10 Йоханнес Гутенберг-Университет Майнц Лекарственное средство от отравлений
MX354005B (es) 2009-09-25 2018-02-08 Shire Orphan Therapies Gmbh Agonistas npr-b novedosos.
TW201121995A (en) 2009-12-18 2011-07-01 Alcon Res Ltd Novel NPR-B agonists
CN104039341A (zh) * 2011-12-16 2014-09-10 卡乐斯治疗公司 用于治疗视网膜病症和疾病的anp(心钠素)、bnp(脑钠素)以及cnp(c型利钠肽)相关肽及其衍生物的方法和用途
EP2948165A2 (en) * 2013-01-25 2015-12-02 Cardiorentis Ltd. A natriuretic peptide, a diuretic peptide or a vasodilatory peptide for use in methods of treating cardiovascular indications
SMT202200173T1 (it) 2016-06-01 2022-05-12 Athira Pharma Inc Composti
US20180215788A1 (en) 2017-02-01 2018-08-02 Shire Human Genetic Therapies, Inc. Compounds and Compositions for the Treatment of Ophthalmic Disorders
JP2021531327A (ja) * 2018-06-19 2021-11-18 セラ セラピューティクス エルエルシー 眼圧降下剤、cnp化合物、nrp−b化合物、tie−2アゴニスト、または神経栄養剤を含む、緑内障または高眼圧症を治療するための徐放性薬剤送達系
CN113382998A (zh) * 2018-11-16 2021-09-10 艾库斯生物科学有限公司 Arg1和/或arg2的抑制剂
KR20230024352A (ko) * 2020-06-12 2023-02-20 파마인 코포레이션 C형 나트륨이뇨 펩타이드 및 이의 급성 폐 손상의 치료에서의 방법

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US4757048A (en) * 1985-11-05 1988-07-12 Biotechnology Research Associates J.V. Synthetic analogs of atrial natriuretic peptides
AU2927889A (en) * 1987-12-24 1989-07-19 California Biotechnology, Inc. Linear analogs of atrial natriuretic peptides
WO1990001940A1 (en) 1988-08-18 1990-03-08 California Biotechnology Inc. Atrial natriuretic peptide clearance inhibitors
EP1118329A4 (en) 1998-09-28 2004-12-15 Santen Pharmaceutical Co Ltd LACRYMAL SECRETION PROMOTERS OR OPHTHALMOLOGICAL DROPS CONTAINING NATRIURETIC PEPTIDES AS ACTIVE INGREDIENTS FOR TREATING KERATOCONJUNCTIVITY
US20040266673A1 (en) * 2002-07-31 2004-12-30 Peter Bakis Long lasting natriuretic peptide derivatives
US6025198A (en) 1999-06-25 2000-02-15 Isis Pharmaceuticals Inc. Antisense modulation of Ship-2 expression
US6436703B1 (en) * 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
IL142118A0 (en) * 2001-03-20 2002-03-10 Prochon Biotech Ltd Method and composition for treatment of skeletal dysplasias
TWI231759B (en) 2001-06-27 2005-05-01 Alcon Inc Olopatadine formulations for topical administration
US7648962B2 (en) 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US7297709B2 (en) 2003-05-22 2007-11-20 Abbott Laboratories Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
WO2006005140A2 (en) * 2004-07-15 2006-01-19 The University Of Queensland Proteinaceous compounds and uses therefor
TW200640443A (en) 2005-02-23 2006-12-01 Alcon Inc Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors
WO2007034498A1 (en) * 2005-09-26 2007-03-29 Compugen Ltd. Atrial natriuretic peptide (anp) splice variants and methods of using same
EP1951277A2 (en) * 2005-10-14 2008-08-06 Biorexis Pharmaceutical Corporation Natriuretic peptide modified transferrin fusion proteins
CA2647146A1 (en) 2006-03-30 2007-10-11 Palatin Technologies, Inc. Linear natriuretic peptide constructs
ES2430323T3 (es) * 2006-03-30 2013-11-20 Palatin Technologies, Inc. Construcciones de péptidos natriuréticos cíclicos
CA2705603A1 (en) * 2007-11-21 2009-05-28 Biomarin Pharmaceutical Inc. Variants of c-type natriuretic peptide
MX354005B (es) * 2009-09-25 2018-02-08 Shire Orphan Therapies Gmbh Agonistas npr-b novedosos.
US8551938B2 (en) 2009-09-25 2013-10-08 Alcon Research, Ltd. NPR-B agonists
TW201121995A (en) 2009-12-18 2011-07-01 Alcon Res Ltd Novel NPR-B agonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102677730B1 (ko) * 2023-03-27 2024-06-27 나인바이오팜 주식회사 지방 분해 효능을 갖는 펩타이드 및 이의 용도

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JP2017137362A (ja) 2017-08-10
WO2011038061A3 (en) 2011-07-28
RU2636738C2 (ru) 2017-11-28
AR078445A1 (es) 2011-11-09
US9745344B2 (en) 2017-08-29
KR20170094564A (ko) 2017-08-18
ZA201201630B (en) 2014-05-28
CL2017001190A1 (es) 2017-12-01
MX354005B (es) 2018-02-08
RU2012116531A (ru) 2013-10-27
CN102548574A (zh) 2012-07-04
JP6211032B2 (ja) 2017-10-11
RU2017139870A (ru) 2019-05-16
CN105732767A (zh) 2016-07-06
MX2012003398A (es) 2012-04-10
US20170313743A1 (en) 2017-11-02
US20130345394A1 (en) 2013-12-26
TWI625126B (zh) 2018-06-01
JP2013505937A (ja) 2013-02-21
RU2557290C2 (ru) 2015-07-20
CA2773949C (en) 2020-11-03
TW201630619A (zh) 2016-09-01
US8546523B2 (en) 2013-10-01
WO2011038061A2 (en) 2011-03-31
EP2480247A2 (en) 2012-08-01
EP2480247B1 (en) 2020-02-12
MX370645B (es) 2019-12-19
US9169293B2 (en) 2015-10-27
TWI577384B (zh) 2017-04-11
ZA201401625B (en) 2018-08-25
JP2015131856A (ja) 2015-07-23
JP5893561B2 (ja) 2016-03-23
US20160194357A1 (en) 2016-07-07
EP2480247A4 (en) 2013-09-04
KR20120091110A (ko) 2012-08-17
PH12012500562A1 (en) 2012-10-22
AU2010298256A1 (en) 2012-04-12
CL2012000715A1 (es) 2012-11-30
US20180334477A1 (en) 2018-11-22
US9982016B2 (en) 2018-05-29
CA2773949A1 (en) 2011-03-31
US20110077381A1 (en) 2011-03-31
ZA201702958B (en) 2018-08-29
AU2010298256B2 (en) 2015-08-13
BR112012006579A2 (pt) 2016-11-22
UY32902A (es) 2011-02-28
KR101768661B1 (ko) 2017-08-16
US10196423B2 (en) 2019-02-05
TW201110974A (en) 2011-04-01
RU2017139870A3 (enExample) 2019-05-16
CN102548574B (zh) 2016-03-23
RU2015124607A (ru) 2015-12-10
KR101854820B1 (ko) 2018-05-04

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