KR20180048798A - 트립토판 디옥시게나제 (ido1 및 tdo)의 억제제 및 치료에서 이들의 용도 - Google Patents
트립토판 디옥시게나제 (ido1 및 tdo)의 억제제 및 치료에서 이들의 용도 Download PDFInfo
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- KR20180048798A KR20180048798A KR1020187008532A KR20187008532A KR20180048798A KR 20180048798 A KR20180048798 A KR 20180048798A KR 1020187008532 A KR1020187008532 A KR 1020187008532A KR 20187008532 A KR20187008532 A KR 20187008532A KR 20180048798 A KR20180048798 A KR 20180048798A
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- nhr
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ711514 | 2015-08-27 | ||
| NZ71151415 | 2015-08-27 | ||
| PCT/NZ2016/050135 WO2017034420A1 (en) | 2015-08-27 | 2016-08-25 | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20180048798A true KR20180048798A (ko) | 2018-05-10 |
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| US (2) | US11414428B2 (https=) |
| EP (1) | EP3350188B1 (https=) |
| JP (2) | JP7334041B2 (https=) |
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| CN (1) | CN108349997B (https=) |
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| CA (1) | CA2996681C (https=) |
| WO (1) | WO2017034420A1 (https=) |
| ZA (1) | ZA201800787B (https=) |
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| CA2996681C (en) * | 2015-08-27 | 2024-04-09 | Auckland Uniservices Limited | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
| WO2018223969A1 (zh) * | 2017-06-05 | 2018-12-13 | 复旦大学 | N-苄基色胺酮类衍生物作为色氨酸双加氧酶(tdo)抑制剂的用途 |
| GB201809050D0 (en) | 2018-06-01 | 2018-07-18 | E Therapeutics Plc | Modulators of tryptophan catabolism |
| CN112823036B (zh) * | 2018-07-03 | 2024-11-08 | 艾福姆德尤股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| TW202235073A (zh) | 2021-01-08 | 2022-09-16 | 美商Ｉｆｍ Ｄｕｅ有限公司 | 用於治療與sting活性相關的病狀之化合物及組合物 |
| WO2022184930A2 (en) | 2021-03-05 | 2022-09-09 | Universität Basel | Compositions for the treatment of ebv associated diseases or conditions |
| EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
| JP2025507981A (ja) | 2022-03-04 | 2025-03-21 | アンティド セラピューティクス インターナショナル ソシエテ ア レスポンサビリテ リミティー | トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の二重阻害剤と療法におけるそれらの使用 |
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| AU2001255410A1 (en) | 2000-04-14 | 2001-10-30 | Corvas International, Inc. | Substituted hydrazinyl heteroaromatic inhibitors of thrombin |
| US20070197610A1 (en) | 2004-03-16 | 2007-08-23 | Janssen Pharmaceutica N.V. | Benzisoxazoles |
| TW200633990A (en) | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
| DE102005018389A1 (de) | 2005-04-20 | 2006-10-26 | Sanofi-Aventis Deutschland Gmbh | Azolderivate als Inhibitoren von Lipasen und Phospholipasen |
| DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| DE102005026194A1 (de) | 2005-06-06 | 2006-12-07 | Grünenthal GmbH | Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| JP5583592B2 (ja) | 2007-11-30 | 2014-09-03 | ニューリンク ジェネティクス コーポレイション | Ｉｄｏ阻害剤 |
| US8461159B2 (en) | 2008-11-25 | 2013-06-11 | Jannsen Pharmaceutica BV | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| US8598356B2 (en) * | 2008-11-25 | 2013-12-03 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| BRPI1009428A2 (pt) | 2009-03-10 | 2016-03-01 | Gruenenthal Gmbh | 3-aminoisoxazolopiridina substituída como moduladores de kcnq2/3 |
| WO2011100614A1 (en) | 2010-02-11 | 2011-08-18 | Vanderbilt University | BENZISOXAZOLES AND AZABENZISOXAZOLES AS mgluR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION |
| PL2595995T3 (pl) | 2010-07-22 | 2016-05-31 | Basf Se | Chwastobójcze izoksazolo[5,4-b]pirydyny |
| JP2015504889A (ja) | 2012-01-12 | 2015-02-16 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 除草性イソオキサゾロ［５，４−ｂ］ピリジン |
| PL220630B1 (pl) | 2012-12-28 | 2015-11-30 | Inst Immunologii I Terapii Doświadczalnej Pan | Nowe sulfonamidowe pochodne izoksazolo[5,4-b]pirydyny o aktywności przeciwbakteryjnej, sposób ich wytwarzania oraz nowe zastosowanie 3-aminoizoksazolo[5,4-b]pirydyny |
| CN105209449B (zh) | 2013-03-14 | 2019-02-01 | 库拉德夫制药私人有限公司 | 犬尿氨酸途径的抑制剂 |
| WO2015082499A2 (en) | 2013-12-03 | 2015-06-11 | Iomet Pharma Ltd | Pharmaceutical compound |
| AU2015302908B2 (en) * | 2014-08-13 | 2020-02-13 | Auckland Uniservices Limited | Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy |
| CA2996681C (en) * | 2015-08-27 | 2024-04-09 | Auckland Uniservices Limited | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
| RU2619120C1 (ru) | 2016-06-06 | 2017-05-12 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | 5-Хлор-3-(3-хлорфенилкарбоксамидо)-4,6-диметилизоксазоло[5,4-b]пиридин в качестве антидота 2,4-Д на подсолнечнике |
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2016
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- 2016-08-25 AU AU2016312848A patent/AU2016312848A1/en not_active Abandoned
- 2016-08-25 JP JP2018511057A patent/JP7334041B2/ja active Active
- 2016-08-25 EP EP16839685.1A patent/EP3350188B1/en active Active
- 2016-08-25 CN CN201680063267.2A patent/CN108349997B/zh active Active
- 2016-08-25 US US15/755,750 patent/US11414428B2/en active Active
- 2016-08-25 KR KR1020187008532A patent/KR20180048798A/ko not_active Withdrawn
- 2016-08-25 WO PCT/NZ2016/050135 patent/WO2017034420A1/en not_active Ceased
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2018
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2021
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2022
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Also Published As
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|---|---|
| CA2996681A1 (en) | 2017-03-02 |
| ZA201800787B (en) | 2025-08-27 |
| AU2016312848A1 (en) | 2018-03-29 |
| AU2021212003B2 (en) | 2023-09-14 |
| EP3350188A1 (en) | 2018-07-25 |
| JP2018525430A (ja) | 2018-09-06 |
| CN108349997B (zh) | 2025-06-10 |
| CA2996681C (en) | 2024-04-09 |
| WO2017034420A1 (en) | 2017-03-02 |
| US20220411438A1 (en) | 2022-12-29 |
| CN108349997A (zh) | 2018-07-31 |
| EP3350188A4 (en) | 2019-04-03 |
| JP7334041B2 (ja) | 2023-08-28 |
| US20180244692A1 (en) | 2018-08-30 |
| AU2021212003A1 (en) | 2021-08-26 |
| US11414428B2 (en) | 2022-08-16 |
| JP2022033753A (ja) | 2022-03-02 |
| HK1258665A1 (en) | 2019-11-15 |
| EP3350188B1 (en) | 2024-03-13 |
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