KR20180048798A - 트립토판 디옥시게나제 (ido1 및 tdo)의 억제제 및 치료에서 이들의 용도 - Google Patents
트립토판 디옥시게나제 (ido1 및 tdo)의 억제제 및 치료에서 이들의 용도 Download PDFInfo
- Publication number
- KR20180048798A KR20180048798A KR1020187008532A KR20187008532A KR20180048798A KR 20180048798 A KR20180048798 A KR 20180048798A KR 1020187008532 A KR1020187008532 A KR 1020187008532A KR 20187008532 A KR20187008532 A KR 20187008532A KR 20180048798 A KR20180048798 A KR 20180048798A
- Authority
- KR
- South Korea
- Prior art keywords
- optionally substituted
- alkyl
- group
- nhr
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ71151415 | 2015-08-27 | ||
| NZ711514 | 2015-08-27 | ||
| PCT/NZ2016/050135 WO2017034420A1 (en) | 2015-08-27 | 2016-08-25 | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20180048798A true KR20180048798A (ko) | 2018-05-10 |
Family
ID=58100623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187008532A Withdrawn KR20180048798A (ko) | 2015-08-27 | 2016-08-25 | 트립토판 디옥시게나제 (ido1 및 tdo)의 억제제 및 치료에서 이들의 용도 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11414428B2 (https=) |
| EP (1) | EP3350188B1 (https=) |
| JP (2) | JP7334041B2 (https=) |
| KR (1) | KR20180048798A (https=) |
| CN (1) | CN108349997B (https=) |
| AU (2) | AU2016312848A1 (https=) |
| CA (1) | CA2996681C (https=) |
| WO (1) | WO2017034420A1 (https=) |
| ZA (1) | ZA201800787B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2996681C (en) * | 2015-08-27 | 2024-04-09 | Auckland Uniservices Limited | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
| CN108969522B (zh) | 2017-06-05 | 2023-03-28 | 复旦大学 | N-苄基色胺酮类衍生物作为色氨酸双加氧酶(tdo)抑制剂的用途 |
| GB201809050D0 (en) | 2018-06-01 | 2018-07-18 | E Therapeutics Plc | Modulators of tryptophan catabolism |
| CN120004785A (zh) * | 2018-07-03 | 2025-05-16 | 诺华制药股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| EP4274824A1 (en) | 2021-01-08 | 2023-11-15 | IFM Due, Inc. | Heterobicyclic compounds having an urea or analogue and their compositions for treating conditions associated with sting activity |
| EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
| MX2023010371A (es) | 2021-03-05 | 2024-02-12 | Univ Basel | Composiciones para el tratamiento de enfermedades o condiciones asociadas al veb. |
| JP2025507981A (ja) | 2022-03-04 | 2025-03-21 | アンティド セラピューティクス インターナショナル ソシエテ ア レスポンサビリテ リミティー | トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の二重阻害剤と療法におけるそれらの使用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001255410A1 (en) | 2000-04-14 | 2001-10-30 | Corvas International, Inc. | Substituted hydrazinyl heteroaromatic inhibitors of thrombin |
| CA2559105A1 (en) | 2004-03-16 | 2005-09-29 | Janssen Pharmaceutica N.V. | Benzisoxazoles |
| TW200633990A (en) | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
| DE102005018389A1 (de) | 2005-04-20 | 2006-10-26 | Sanofi-Aventis Deutschland Gmbh | Azolderivate als Inhibitoren von Lipasen und Phospholipasen |
| DE102005038947A1 (de) | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| DE102005026194A1 (de) * | 2005-06-06 | 2006-12-07 | Grünenthal GmbH | Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| US10047066B2 (en) | 2007-11-30 | 2018-08-14 | Newlink Genetics Corporation | IDO inhibitors |
| US8461159B2 (en) | 2008-11-25 | 2013-06-11 | Jannsen Pharmaceutica BV | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| WO2010068452A1 (en) * | 2008-11-25 | 2010-06-17 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| CA2754934A1 (en) | 2009-03-10 | 2010-09-16 | Gruenenthal Gmbh | Substituted 3-aminoisoxazolopyridines as kcnq2/3 modulators |
| MX2012009377A (es) | 2010-02-11 | 2012-09-12 | Univ Vanderbilt | Benzotiazoles y azabenzotiazoles como potenciadores alostericos mglur4, composiciones y metodos para tratar la disfuncion neurologica. |
| DK2595995T3 (en) | 2010-07-22 | 2016-02-29 | Basf Se | Herbicidal isoxazolo [5,4-b] pyridines |
| EP2802212B1 (en) | 2012-01-12 | 2015-12-30 | Basf Se | Herbicidal isoxazolo[5,4-b]pyridines |
| PL220630B1 (pl) | 2012-12-28 | 2015-11-30 | Inst Immunologii I Terapii Doświadczalnej Pan | Nowe sulfonamidowe pochodne izoksazolo[5,4-b]pirydyny o aktywności przeciwbakteryjnej, sposób ich wytwarzania oraz nowe zastosowanie 3-aminoizoksazolo[5,4-b]pirydyny |
| SG11201507395PA (en) | 2013-03-14 | 2015-10-29 | Curadev Pharma Private Ltd | Inhibitors of the kynurenine pathway |
| US9931347B2 (en) | 2013-12-03 | 2018-04-03 | Iomet Pharma Ltd. | Pharmaceutical compound |
| KR102746352B1 (ko) | 2014-08-13 | 2024-12-24 | 오클랜드 유니서비시즈 리미티드 | 트립토판 디옥시게나제 (ido1 및 tdo)의 억제제 및 치료에서 이들의 용도 |
| CA2996681C (en) * | 2015-08-27 | 2024-04-09 | Auckland Uniservices Limited | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
| RU2619120C1 (ru) | 2016-06-06 | 2017-05-12 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | 5-Хлор-3-(3-хлорфенилкарбоксамидо)-4,6-диметилизоксазоло[5,4-b]пиридин в качестве антидота 2,4-Д на подсолнечнике |
-
2016
- 2016-08-25 CA CA2996681A patent/CA2996681C/en active Active
- 2016-08-25 AU AU2016312848A patent/AU2016312848A1/en not_active Abandoned
- 2016-08-25 EP EP16839685.1A patent/EP3350188B1/en active Active
- 2016-08-25 JP JP2018511057A patent/JP7334041B2/ja active Active
- 2016-08-25 CN CN201680063267.2A patent/CN108349997B/zh active Active
- 2016-08-25 WO PCT/NZ2016/050135 patent/WO2017034420A1/en not_active Ceased
- 2016-08-25 KR KR1020187008532A patent/KR20180048798A/ko not_active Withdrawn
- 2016-08-25 US US15/755,750 patent/US11414428B2/en active Active
-
2018
- 2018-02-06 ZA ZA2018/00787A patent/ZA201800787B/en unknown
-
2021
- 2021-08-03 AU AU2021212003A patent/AU2021212003B2/en active Active
- 2021-11-08 JP JP2021182007A patent/JP2022033753A/ja active Pending
-
2022
- 2022-08-15 US US17/888,281 patent/US20220411438A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HK1258665A1 (en) | 2019-11-15 |
| JP2022033753A (ja) | 2022-03-02 |
| ZA201800787B (en) | 2025-08-27 |
| CN108349997A (zh) | 2018-07-31 |
| EP3350188A1 (en) | 2018-07-25 |
| AU2016312848A1 (en) | 2018-03-29 |
| US20220411438A1 (en) | 2022-12-29 |
| CA2996681C (en) | 2024-04-09 |
| JP2018525430A (ja) | 2018-09-06 |
| AU2021212003B2 (en) | 2023-09-14 |
| EP3350188A4 (en) | 2019-04-03 |
| US11414428B2 (en) | 2022-08-16 |
| EP3350188B1 (en) | 2024-03-13 |
| US20180244692A1 (en) | 2018-08-30 |
| CN108349997B (zh) | 2025-06-10 |
| AU2021212003A1 (en) | 2021-08-26 |
| CA2996681A1 (en) | 2017-03-02 |
| JP7334041B2 (ja) | 2023-08-28 |
| WO2017034420A1 (en) | 2017-03-02 |
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| US12508268B2 (en) | Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy | |
| AU2021212003B2 (en) | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY | |
| JP5692696B2 (ja) | キナーゼ阻害剤としてのアリール尿素 | |
| HK1258665B (en) | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy | |
| HK1238549B (en) | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy | |
| HK1238549A1 (en) | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20180326 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |