KR20180026808A - 섬유성 질환을 치료하기 위한 vap―1 억제제의 용도 - Google Patents

섬유성 질환을 치료하기 위한 vap―1 억제제의 용도 Download PDF

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KR20180026808A
KR20180026808A KR1020187006357A KR20187006357A KR20180026808A KR 20180026808 A KR20180026808 A KR 20180026808A KR 1020187006357 A KR1020187006357 A KR 1020187006357A KR 20187006357 A KR20187006357 A KR 20187006357A KR 20180026808 A KR20180026808 A KR 20180026808A
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Prior art keywords
fibrosis
ser
vap
gly
val
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Korean (ko)
Inventor
크리스토퍼 웨스턴
리 찰스 클라리지
데이비드 애덤스
데이비드 스미스
니나 베스테르룬드
마리오 피흐라비스토
트후아 외스테르만
Original Assignee
바이오티에 세라피스 코포레이션
더 유니버시티 오브 버밍햄
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Publication of KR20180026808A publication Critical patent/KR20180026808A/ko
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • GPHYSICS
    • G01MEASURING; TESTING
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • GPHYSICS
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • GPHYSICS
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/902Oxidoreductases (1.)
    • G01N2333/906Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
    • G01N2333/90605Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4)
    • G01N2333/90633Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3) in general
    • G01N2333/90638Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3) in general with a definite EC number (1.4.3.-)
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    • G01N2800/08Hepato-biliairy disorders other than hepatitis
    • G01N2800/085Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin

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  • Heart & Thoracic Surgery (AREA)
KR1020187006357A 2009-09-08 2010-09-07 섬유성 질환을 치료하기 위한 vap―1 억제제의 용도 Ceased KR20180026808A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24040209P 2009-09-08 2009-09-08
US61/240,402 2009-09-08
US32303210P 2010-04-12 2010-04-12
US61/323,032 2010-04-12
PCT/FI2010/050689 WO2011029996A1 (en) 2009-09-08 2010-09-07 Use of vap-1 inhibitors for treating fibrotic conditions

Related Parent Applications (1)

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KR1020127009075A Division KR101837117B1 (ko) 2009-09-08 2010-09-07 섬유성 질환을 치료하기 위한 vap―1 억제제의 용도

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KR20180026808A true KR20180026808A (ko) 2018-03-13

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Application Number Title Priority Date Filing Date
KR1020187006357A Ceased KR20180026808A (ko) 2009-09-08 2010-09-07 섬유성 질환을 치료하기 위한 vap―1 억제제의 용도
KR1020127009075A Expired - Fee Related KR101837117B1 (ko) 2009-09-08 2010-09-07 섬유성 질환을 치료하기 위한 vap―1 억제제의 용도

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Application Number Title Priority Date Filing Date
KR1020127009075A Expired - Fee Related KR101837117B1 (ko) 2009-09-08 2010-09-07 섬유성 질환을 치료하기 위한 vap―1 억제제의 용도

Country Status (27)

Country Link
US (2) US9795671B2 (https=)
EP (1) EP2475387B1 (https=)
JP (3) JP6009355B2 (https=)
KR (2) KR20180026808A (https=)
CN (2) CN102740886A (https=)
AU (1) AU2010294123B2 (https=)
CA (1) CA2773218C (https=)
CY (1) CY1119867T1 (https=)
DK (1) DK2475387T3 (https=)
ES (1) ES2657943T3 (https=)
HR (1) HRP20180131T1 (https=)
HU (1) HUE035890T2 (https=)
IL (1) IL218535A (https=)
LT (1) LT2475387T (https=)
ME (1) ME02999B (https=)
NO (1) NO2475387T3 (https=)
NZ (3) NZ598920A (https=)
PL (1) PL2475387T3 (https=)
PT (1) PT2475387T (https=)
RS (1) RS56809B1 (https=)
RU (2) RU2667963C1 (https=)
SG (1) SG179012A1 (https=)
SI (1) SI2475387T1 (https=)
SM (1) SMT201800043T1 (https=)
UA (1) UA112154C2 (https=)
WO (1) WO2011029996A1 (https=)
ZA (1) ZA201202515B (https=)

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JP5953035B2 (ja) * 2011-11-28 2016-07-13 学校法人慶應義塾 病理診断支援装置、病理診断支援方法、及び病理診断支援プログラム
AU2013255103B2 (en) 2012-05-02 2016-09-29 Syntara Limited Substituted 3-haloallylamine inhibitors of SSAO and uses thereof
WO2014024820A1 (ja) * 2012-08-06 2014-02-13 塩野義製薬株式会社 新規慢性腎臓病治療用医薬組成物及び新規慢性腎臓病治療薬のスクリーニング方法
KR102205845B1 (ko) 2013-10-28 2021-01-22 삼성전자주식회사 입자에 기반한 모델링 방법 및 장치
WO2015189534A1 (en) * 2014-06-12 2015-12-17 Proximagen Limited Vap-1 inhibitors for treating muscular dystrophy
JP2018080114A (ja) * 2015-05-29 2018-05-24 株式会社アールテック・ウエノ 抗ヒトvap−1モノクローナル抗体
WO2019003159A1 (en) * 2017-06-27 2019-01-03 Neuracle Science Co., Ltd. USE OF ANTI-FAM19A5 ANTIBODIES FOR THE TREATMENT OF FIBROSIS
CN119156402A (zh) * 2022-02-23 2024-12-17 耶鲁大学 用作肾病治疗物的il-6抑制剂
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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