KR20170125750A - Oral composition - Google Patents

Abstract

The present invention relates to an oral composition and a manufacturing method thereof. According to the present invention, the oral composition is capable of maximizing an oral anti-inflammatory effect, or maximizing an effect of improving periodontal diseases. The oral composition includes a centella asiatica extract, a Titrated extract of Zea Mays L. unsaponifiable fraction, and a machilia extract as effective components. The centella asiatica extract, the Titrated extract, and the machilia extract are 0.003-0.5 wt% to the total weight.

Description

Oral composition [0002]

Toothpaste and the like, and a method of manufacturing the same.

Dental tissue is composed of enamel, cement and dentin. The outer surface of the exposed teeth is covered with enamel, and the outer part of the tooth root located in the alveolar bone is covered with cementite, and the dentin is present inside these teeth. In the dentin, a fine tube called the dentinal tubule is distributed throughout the dentin.

Symptoms of toothache This symptom is felt when the dentin part of an exposed tooth is contacted with cold air or irritating food or the like. As a fundamental cause of this symptom, many tubules existing in the tooth dentin are exposed to the outside. Symptoms of toothache can range from mild symptoms to severe and persistent pain. In addition, since teeth are not regenerated by nature, the use of analgesics or anti-inflammatory agents is not a fundamental solution to the symptom of sehirin, so various treatments have been developed to relieve the symptoms of sehirin.

There are two major treatments for this symptom: ivory tubular septation and dimensional neuron desensitization. The dentinal tubule sealing method is a method in which the exposed dentinal tubules are filled with resin or the like and the enamel lost by fluoride application is recovered again. In the dental neuron desensitization method, the neurotransmission is controlled by the proper ratio of sodium ion and potassium ion To increase the content of potassium ions by artificially increasing the nerve is not feeling the pain is a treatment. However, there is a need for dental care for these specialized therapies, so toothpastes for syringes that can treat or prevent syringitis in everyday life are being sold.

These toothpastes contain an active ingredient useful in the above two therapeutic methods. However, toothpastes containing potassium phosphate, potassium phosphate, and the like are designed to exhibit the effect of the dental neuron desensitizing effect, the dentifrice having an efficacy by the ivory tubular sealing method which exhibits relatively high efficacy is preferred because the time for the efficacy is as long as 15 days have.

However, a conventional toothpaste using a conventional ivory tubular sealing effect contains a fine powder of an effective ingredient to seal the ivory tubule. In general, the toothpaste is diluted in the process of brushing, and is washed away most of the time in the course of rinsing with water There is a problem in that the customs pipe is not sealed and exposed again.

On the other hand, the causes of bad breath are largely classified into oral causes, oral and external causes, and oral causes account for 80% to 90% of the causes of bad breath. Decrease in the amount of oral microorganisms, increase in activity of the oral microorganisms, and oral diseases such as adhesions on the back of the tongue and untreated dental caries and periodontal diseases.

On the other hand, dental caries and periodontal diseases among oral diseases cause various clinical symptoms such as pain, chewing dysfunction, periodontal tissue destruction and bad breath, and are known to be the main cause of tooth loss. The factor is increasing.

A variety of antimicrobial agents including antibiotics, which have bactericidal and bacteriostatic action against these bacteria, are used to prevent tooth decay, periodontal disease and bad breath, Have been developed as inhibitors and remedies for periapical infections.

However, since antibiotics cause systemic adverse effects on our body and cause the appearance of resistant bacteria and oral hyposensitis in the oral cavity, they are difficult to use for a long time and can only be used as a therapeutic agent. In addition, fluoride, which is an antimicrobial agent, has a pronounced effect of preventing tooth decay, but the effects of periodontal disease and periodontal disease have not been reported yet. Other antimicrobial agents used in toothpaste, toothpaste, or other oral cleansers include sanguinarine, listerine, peroxide or chlorohexidine. However, there is a disadvantage in that the effect of ginseng is not clear on the bacteria in the oral cavity, the effect of treating periodontal disease is more unclear, and the price is also high. Listerine is a major ingredient in alcohol, However, there is a disadvantage that it can show a harmful effect on tissue during long-term use. Recently, peroxide which is added for the whitening effect has a toxic action against bacteria, but at the same time, However, occasionally bacteria resistant to peroxides are also emerging. In addition, chlorhexidine is known to be the most excellent agent known to date as a preventive and therapeutic agent for periodontal disease in addition to suppression of plaque formation. However, chlorhexidine has been widely used as a stimulant for tissue, coloration and degeneration of tissue, (RJ Genco, RJ Genco, RJ Genco, RJ Genco, RJ Genco, RJ Genco, and RJ Genco. et al., p161-169, p368-369, p433, CV Mosby Company, St. Louis, 1990).

Accordingly, efforts have been made to develop natural materials excellent in the prevention, improvement, or treatment effects of disorders or diseases occurring in the oral cavity, and to improve the efficacy of the developed natural materials, without concern for the above- have.

It is an object of the present invention to provide an oral composition and a method for manufacturing the same, which are excellent in the improvement of the disorder, disease or various harmful symptoms occurring in the oral cavity, in particular, the anti-inflammatory effect is maximized.

In order to solve the above-mentioned problems,

The present invention provides an oral composition comprising a natural material having an excellent anti-inflammatory effect in oral cavity as an active ingredient and a method for producing the same.

More specifically, the present invention provides an oral antiinflammatory composition comprising Centella asiatica extract, corn-inhabited extract and succulent extract as an active ingredient, and a method for producing the same.

The inventors of the present invention have confirmed the anti-inflammatory and antimicrobial effects of Centella asiatica, corn-inhabited extract, and horsetail, while screening a large number of natural materials usable in the human body. However, inflammatory diseases in the oral cavity, including periodontal disease, are caused by multiple causes and worsen. As a result, only the use of each of the Centella asiatica, corn-inhabited extract or succulent extract alone causes the antibacterial action against the causative bacteria of inflammation, And the inhibition and regeneration of connective tissue disruption and alveolar bone disruption, and thus it is difficult to exhibit a complex and broad effect, and thus, it is not effective as an oral antiinflammatory composition. However, it has been confirmed that the use of Centella asiatica extract, corn-inhabited extract and succulent extract at a specific weight ratio causes synergistic action between them to exhibit maximal anti-inflammatory activity in the oral cavity. It was confirmed that the effect is further improved by adding a water-soluble plant tincture, and the present invention has been completed.

[extract]

In the present invention, the term "extract" means an extract obtained by an extraction treatment, a dilute or concentrated solution of the extract, a dried product obtained by drying the extract, a controlled preparation or a purified product of the extracted solution, And extracts of all formulations which can be formed using extracts. The dried material can be obtained through ordinary processes known in the art such as vacuum drying, freeze drying or spray drying. The purified product may be subjected to a conventional purification process, for example, separation of the membrane using a filtration membrane having a cut-off value at a constant molecular weight, separation by various chromatographies for separation according to size, charge, hydrophobicity or affinity ≪ / RTI >

The extract includes each plant described below and may include its leaves, stems, stems, bark, roots, flowers or flowers, fruits, seeds, sap, fruits and whole plants in addition to the specified parts, Extraction is also possible.

To prepare the extract, one of ordinary skill in the art can use any suitable method known in the art. For example, a solvent extraction method can be used. The entire plant or any portion thereof may be ground (e.g., a blender) and then the extraction solvent may be treated to obtain a solvent extract. It may be dried and then pulverized before pulverization. In addition, the solvent extract may be prepared in powder form by an additional process such as vacuum distillation and freeze-drying or spray-drying. The kind of the extraction solvent used is not particularly limited, and any solvent known in the art can be used. Non-limiting examples of the extraction solvent include water; C1 to C4 lower alcohols such as methanol, ethanol, propyl alcohol and butyl alcohol; Polyhydric alcohols such as glycerin, butylene glycol and propylene glycol; And hydrocarbon solvents such as methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, and dichloromethane; Or a mixture thereof. The solvent extract may be prepared by extracting the extract at least one time using the solvent, and the dry extract obtained by vacuum distillation or spray drying the solvent extract may be prepared. The amount of the extraction solvent may vary depending on the kind of the extraction solvent used, but may be, for example, 1 to 20 times, or 5 to 20 times the dry weight of the target plant.

In addition, various extraction processes known in the art such as, for example, maceration, infusion, percolation, digestion, decoction, hot continuous extraction, aqueous- (For example, hydrofluoro-carbon solvent), etc.), which may be used alone or in combination with one another, may be used, for example, May be carried out by using two or more methods in combination.

The centella asiatica extract, corn-inhabited extract and succulent extract, which are used as an active ingredient of the oral anti-inflammatory composition of the present invention, can be used as a water-insoluble anti-inflammatory agent to remarkably improve the anti-inflammatory effect of the composition.

Centella asiatica belongs to the genus Umbelliferae (Apiaceae), especially the hydrocotyle subspecies. Active compounds included in centella asiatica include, for example, triterpene genin forms: asiatic acid and madecassic acid; Or triterpene heteroside forms: asiaticoside, madecassoside, and terminoloside; pentacyclic triterpene, and the like. It is native to Korea, and is a perennial plant distributed mainly in the islands of southern Korea.

The centella asiatica extract according to the present invention refers to the results of various formulations obtained by extraction treatment with Centella asiatica. The Centella asiatica extract may be extracted from various organs of a natural, hybrid or variant plant of Centella asiatica and may be obtained from a variety of plants such as seeds, roots, shoots, stems, leaves, flowers, It can be extracted not only from the skin of the fruit but also from the plant tissue culture, but it can be extracted with the stem or the leaf.

The Centella asiatica extract according to the present invention is not particularly limited, but may be preferably a solvent extraction method. The extraction solvent may be obtained by treating the Centella asiatica with an extraction solvent. The type of the extraction solvent to be used is not particularly limited and any solvent known in the art may be used. For example, water, C1 to C4 lower alcohols such as methanol, ethanol, propyl alcohol and butyl alcohol, and mixtures thereof.

The centella asiatica extract according to the present invention may contain a variety of active compounds derived from centella asiatica, but preferably contains the anticoside and the genin, 44% by weight, and 54-66% by weight total ginsin (madecanoic acid and asialic acid).

The Centella asiatica extract according to the present invention is insoluble in water, for example, soluble in pyridine, soluble in ethanol, acetic acid, propylene glycol and dioxane, but insoluble in benzene and water. Thus, it is present in the form of a tablet in the form of a paste containing an excessive amount of water, for example, toothpaste.

The titrated extract of the unsweetable fraction of Zea Mays L. means saponification reaction to corn ( Zea Mays L.), followed by a quantitative extraction of the remaining unsaponifiables. The unsaponifiable material is a lipid component that does not dissolve in water but reacts with strong alkali to make soluble soap, and includes, for example, hydrocarbons, fat soluble pigments, fat soluble vitamins and the like.

The corn used to obtain the corn-deficient extract according to the present invention may be natural, hybrid or variant plants, and is not limited to a specific country of origin or distribution.

The corn-deficient extract according to the present invention may include various active compounds derived from corn-deficient extracts such as phytosterol, squalene, carotene, topoparol and the like, wherein the phytosterol is a compound selected from the group consisting of beta-sitosterol, alpha-sitosterol , Or campesterol, and the like, preferably beta-sitosterol.

The corn-depleted extract according to the present invention can be obtained through various methods known in the art, and commercially available ones can also be used. For example, corn oil extracted from corn (for example, corn germ, etc.) is subjected to continuous saponification using a caustic soda solution and an organic solvent (for example, n-hexane) Can be prepared.

The corn-deficient extract according to the present invention is insoluble in water and is present in the form of a tablet in the form of a paste containing an excessive amount of water, for example, toothpaste.

Magnolia bark is a species of Magnolia ovobata Thunberg, Magnolia officinalis Rehder et Wilson or Magnolia officinalis Rehder et Wilson var biloba Rehder et Wilson Magnoliaceae, ).

The afterglow extract according to the present invention refers to the result of various formulations obtained through extraction treatment on tobacco. The backbone extracts can be extracted from various organs of natural, hybrid or variant plants of the backbone and can be used for various plant organs such as, for example, various organs or parts such as leaves, flowers, fruits, stems, roots, Although it can be extracted from water, it can be preferably extracted using a shell.

The afterglow extract according to the present invention is not particularly limited, but can be preferably subjected to a supercritical fluid extraction method. The supercritical fluid extraction method is a method for extracting and separating a substance using the solubility of a supercritical fluid solvent. When the sample and the supercritical fluid solvent come into close contact with each other, solubility in the sample dissolves into supercritical fluid due to difference in solubility, The supercritical fluid containing the solute from the extraction step is separated from the solute in the separation step by temperature and / or pressure. The solvent that can be used in the supercritical fluid extraction method according to the present invention is preferably supercritical carbon dioxide, and can be extracted under a pressure condition of preferably 30 to 60 ° C and / or 10 to 30 mpa. In order to extract supercritical fluid, it is necessary to use RESS (Rapid Expansion of Supercritical Solutions), GAS (Gas Anti-Solvent), SAS (Supercritical fluid Anti-Solvent), ASES (Aerosol Solvent Extraction System), SEDS (Solution Enhanced Dispersion by Supercritical Fluids) Particles from Gas Saturated Solutions (PGSS) or Reactive Precipitation in Supercritical Solution (RPSS).

Since the extract of Capsicums according to the present invention is insoluble in water, it is present in the form of a tablet in the form of paste containing a large amount of water, for example, toothpaste.

The composition according to the present invention contains, as an active ingredient, all three of Centella asiatica extract, corn-inhabited extract and succulent extract.

As used herein, the term "active ingredient" alone means an ingredient which exhibits the desired activity or which can exhibit activity together with a carrier which itself is not active.

In the present invention, the anti-inflammatory oral composition may contain 0.003-0.5% by weight, more preferably 0.005-0.3% by weight, of Centella asiatica extract, corn-inhabited extract, As shown in FIG.

In the present invention, the Centella asiatica extract may be contained in an amount of 0.001 to 0.2% by weight, preferably 0.005 to 0.1% by weight, based on the total weight of the composition. The corn-deficient extract may be contained in an amount of 0.001 to 0.2% by weight, preferably 0.005 to 0.1% by weight. The afterglow extract may be contained in an amount of 0.001 to 0.2% by weight, preferably 0.005 to 0.1% by weight.

In the present invention, the composition for oral cavity for anti-inflammation may contain two or more of the active ingredients Centella asiatica extract, corn-inhabited extract, and succulent extract. (Centella asiatica extract: Capsicum extract) at a weight ratio of 1: 1 to 20, preferably 1: 2 to 10, more preferably 1: 3 to 6, when the active ingredient is Centella asiatica extract and succulent extract have. When the effective component is Centella asiatica extract or corn-inhabited extract, the weight ratio of Centella asiatica extract to corn (1: 0.5 to 10, preferably 1: 1 to 7, more preferably 1: 2 to 5, Non-digested extract). In addition, when the active ingredient is a corn-inactivation-free extract or an aftertaste extract, it can be a weight ratio of 1: 0.5 to 20, preferably 1: 1 to 10, and more preferably 1: 2 to 5 (corn-inactivation extract: have.

In the present invention, when the active ingredient is composed of Centella asiatica extract, corn-inhabited extract and succulent extract, the weight ratio of Centella asiatica extract, corn-inhabited extract and succulent extract is 1: 0.5 to 10: , Preferably 1: 1 to 7: 2 to 10, more preferably 1: 2 to 5: 3 to 6, most preferably 1: 2: 5 (Centella asiatica extract: corn-inactivation extract: .

Preferably, the anti-inflammatory oral composition of the present invention exhibits the best anti-inflammatory activity when the active ingredient is contained in the above-mentioned content or weight ratio range.

[Plant tincture]

In addition to the three extracts described above, the composition according to the present invention may further comprise a water-soluble plant extract.

The plant tincture refers to a pharmaceutical preparation prepared by leaching a plant with a mixture of ethanol and purified water.

The water soluble plant tincturing agent according to the present invention may be various water soluble plant tincturing agents conventionally used in the art within the scope of not adversely affecting the effects of the present invention. The water soluble plant tincturing agents may be selected from the group consisting of mallow tincture, lattice tincture, Mulletin, and mixtures of two or more thereof.

The myrrh tinct is a tincture using myrrh. The myrrh is a bitter tasting, yellowish reddish brown resin rubber which is bitter and fragrant, and is used in a small and prickly flowering tree of Commiphora It is obtained from plants such as Commiphora myrrha and Commiphora abyssinica, but it is a substance distinguishable from the mentioned plant (Commiphora myrrha). The latinia tincture is a tincture using rhatany, and the lattiana is a plant belonging to the family Crameria casaea and is an indigenous plant in Ecuador, Peru and Bolivia. It grows on the western slopes of the Andes, 1,000 to 3000 meters above sea level. Latania is typically dried roots. The above-mentioned chamomile is a tincture using chamomile, and the chamomilla is also referred to as chrysanthemum, and is the origin of Europe. The stem is divided from the lower part by a lot of branches, and the height is 50cm ~ 100cm. In Europe, she suffered from neuralgia, toothache and dysmenorrhea in the private, and was used for oralitis, conjunctivitis, and pyrogenesis. Camomile is used as an anti-inflammatory, anti-convulsant, antiseptic, disinfectant and uses dry flower peaks. Chamazulene, α-bisabolol oxide A, α-bisabolol oxide B, and bisabolone oxide A are the main components.

The plant tinctures may be commercially available products or may be prepared according to various methods known in the art, for example, maceration or percolation. The cold precipitation method is a method in which a plant is immersed in a leaching agent at room temperature to leach a soluble component, and the percolation method is a leaching of a soluble component through a leaching agent to a plant layer filled in a percolator.

In the composition according to the present invention, the water-soluble plant tincture may be contained in an amount of 0.005 to 3% by weight, preferably 0.01 to 2% by weight, more preferably 0.02 to 1.5% by weight, based on the total weight of the composition. When the water soluble plant extract is contained in an amount of 0.005 to 3% by weight, particularly excellent effects can be exhibited by using the extracts together with the three kinds of extracts.

In the composition according to the present invention, the weight ratio of the water-soluble plant tincture to the three extracts may be 1: 0.01 to 100, preferably 1: 0.1 to 50 (plant tincture: extract) Particularly excellent effects can be exhibited in the range.

[Additional Ingredients]

To the composition according to the present invention, a known additive component that can be used in the composition for oral use may be added to the composition for the purpose of proper formulation and formulation stability, improvement of desired effect, can do. Examples of such additives include abrasives, wetting agents, binders, foaming agents, sweeteners, pH adjusting agents, dentifrice preventive agents, perfumes, solvents, and desensitizers. Specific examples of the additive components have been described below, but the components that can be incorporated into the oral composition of the present invention are not limited thereto.

The abrasive may be, for example, silica, silica gel, zirconium silicate, calcium monohydrogenphosphate, calcium monohydrogenphosphate anhydrous, hydrated alumina, light calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble metaphosphate and aluminum silicate Although not limited thereto, silica may preferably be used. The abrasive may be contained in an amount of 1 to 20% by weight based on the total weight of the polishing compound.

Examples of the wetting agent include, but are not limited to, concentrated glycerin, glycerin, sorbitol aqueous solution, amorphous sorbitol aqueous solution, polyethylene glycols, propylene glycol, and the like.

Examples of the binder include sodium carboxymethylcellulose, carrageenan, xanthan gum, hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, guar gum, gellan gum, carbomer, pectin, polyvinylpyrrolidone , Carboxyvinylpolyol, at least one selected from the group consisting of sodium alginate and laponite, preferably carboxymethyl cellulose sodium or xanthan gum, but are not limited thereto.

Examples of the foaming agent include, but are not limited to, anionic and nonionic surfactants such as sodium alkylsulfate, sodium laurylsulfate, sucrose fatty acid ester, and sorbitan fatty acid ester.

Examples of the sweetening agent include, but are not limited to, sodium saccharin, sucralose, maltitol, aspartame, erythritol, xylitol, and licorice acid.

Examples of the preservative include, but are not limited to, benzoic acid, methylparaben, propylparaben, paraoxybenzoic acid ester, and sodium benzoate.

Examples of the tooth decay agent include sodium fluoride, sodium fluorophosphate, tin fluoride, chlorohexidine, allantoin chlorohydroxy aluminate, aminocaproic acid, zinc chloride, pyridoxine hydrochloride, tocopheryl acetate and enzymes. It is not limited.

As the fragrance, peppermint oil, spearmint oil, menthol, etc. may be used singly or in combination, but the present invention is not limited thereto.

Examples of the pH adjuster include sodium phosphate, disodium phosphate, citric acid, triethanolamine, and the like, but are not limited thereto.

Examples of the desensitizer include enzymes such as sodium fluoride, potassium fluoride, ammonium fluoride, fluoride such as tin fluoride and sodium monofluorophosphate, amylase, protease, lysozyme and dextranase, and vitamins B, C and E Potassium nitrate, aluminum lactate, and the like can be used, but the present invention is not limited thereto. The desensitizer may include 0.01 to 5% by weight based on the total weight.

Examples of the solvent include water and lower alcohols having 1 to 4 carbon atoms. When the composition for oral use contains water as a solvent, its content may be 20 to 95% by weight based on the total weight of the oral composition. When the oral composition contains a lower alcohol as a solvent, the content thereof may be 1 to 30% by weight based on the total amount of the oral composition.

In addition to the above-described additive components, natural materials well known in the art may be further included within the scope of not damaging the effects of the present invention. For example, it may include, but is not limited to, cucurbitaceae extract, rhizome extract, Angelica gigantosa extract, or a mixture thereof. The content of each extract may be 0.001 to 1% by weight based on the total weight of the oral composition.

[Composition]

The formulation and shape of the oral composition according to the present invention are not particularly limited and may be, for example, a liquid (solution, emulsion, suspension), a semi-solid (gel, cream, paste, etc.) , Film, kneaded product, molten solid, wax-like solid, elastic solid, etc.).

In addition, the formulated preparations can be used in various forms such as, for example, a skirt (a skirt, a liquid skirt, a liquid skirt, a skirt, etc.), a curing agent, a coating agent, a patch, , Candy, gumi, film, troch, etc.), but is not limited to the above in the range of oral use.

[Effectiveness / Effect]

The oral composition according to the present invention exhibits excellent anti-inflammatory activity.

By the combination of Centella asiatica extract, corn-inhabited extract, and backyard extract, synergistic effects exceed the sum of the effects of plants, their intermediates, and their final substances, the starting material of each extract.

The anti-inflammatory oral composition according to the present invention has excellent antibacterial activity in addition to anti-inflammation.

The oral composition according to the present invention has an excellent antiinflammatory or antimicrobial activity and is effective in improving various diseases, disorders or harmful symptoms that may occur in the oral cavity.

In the present specification, the term " improvement "includes treatment, prevention and alleviation, and the term " prevention" can be understood as a comprehensive concept of prevention before a disease or the like occurs. The "mitigation" means that the disease is reduced or alleviated, and can be understood as a broad concept including improvement, prevention, and treatment. "Treatment" can be understood as a broad concept which means restoring the disease or the like to a state close to the original state that did not occur.

The composition for oral use according to the present invention is particularly effective for improving periodontal disease.

Periodontal disease is divided into periodontal disease (gingivitis) and periodontitis (periodontal disease) depending on the severity of the disease. The periodontal disease is called gingivitis, which is a relatively light and fast-regenerating periodontal disease. Gingivitis caused by inflammation of the gums and gums around the bone is called progression is called gingivitis. This periodontal disease progresses as the protein in the oral saliva forms a thin film on the surface of the teeth and the bacteria adhere with the food, the exfoliated epidermis, and the white blood cell. Bacteria accumulate with minerals and generate plaque and release toxins such as Lipopolysaccharide (LPS), nuclease, leukotoxin, and hydrogen sulfide to cause inflammation in the surrounding tissues, forming a periodontal bag between the teeth and gums. As a result of secretion of various cytokines from host immune cells and secretion of matrix metalloproteinase (MMP) by host immune cells and bacteria, the depth of the periodontal pouch becomes deeper as the inflammatory reaction becomes more severe, causing gingival recession and bone loss The periodontal disease is progressing. The major anaerobic bacteria that cause periodontal disease include, but are not limited to, Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Treponema denticola, (Prevotella intermedia).

[Manufacturing method]

The composition according to the present invention can be produced according to a conventional method known in the art. Specifically, a powder component such as sodium carboxymethyl cellulose and saccharin is dispersed in Solvitol solution, which is a wetting component, and purified water is added, followed by primary mixing in a mixer, and then an abrasive such as precipitated silica and a medicinal agent are added and mixed Finally, the fragrance ingredient may be added and mixed under vacuum to prepare an oral composition.

According to the present invention, there is an excellent effect that the anti-inflammatory effect in the oral cavity is maximized, and further, the improvement effect on periodontal disease is maximized.

Hereinafter, embodiments of the present invention will be described in detail to facilitate understanding of the present invention. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following embodiments. Embodiments of the invention are provided to more fully describe the present invention to those skilled in the art.

Example : Preparation of oral composition

The dentifrice compositions of Examples 1 to 4 and Comparative Examples 1 to 4 were prepared with the components and composition ratios shown in Table 1 below. Specifically, powder components such as sodium carboxymethyl cellulose and saccharin were dispersed in Solvitol solution, which is a wetting component, and purified water was added, followed by primary mixing in a mixer, and then an abrasive such as precipitated silica and a medicinal agent were added and mixed . Finally, the perfume ingredients were added and mixed under vacuum to prepare dentifrice compositions with the components and composition ratios shown in Table 1 below.

division Example Comparative Example One 2 3 4 One 2 3 4 Dental type silica 14,000 14,000 14,000 14,000 14,000 14,000 14,000 14,000 Sorbitol solution (70%) 50,000 50,000 50,000 50,000 50,000 50,000 50,000 50,000 Sodium saccharin 0.100 0.100 0.100 0.100 0.100 0.100 0.100 0.100 Carboxymethylcellulose 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 Spices 1,000 1,000 1,000 1,000 1,000 1,000 1,000 1,000 Sodium lauryl sulfate 2.000 2.000 2.000 2.000 2.000 2.000 2.000 2.000 Purified water Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Acacia extract 0.001 0.050 0.100 0.200 - 0.001 - - Centella asiatica extract 0.001 0.010 0.020 0.050 - - 0.001 - Corn-deficient quantitative extract 0.001 0.020 0.040 0.050 - - - 0.001

The dentifrice compositions of Examples 5 to 19 were prepared with the components and composition ratios shown in Table 2 below.

Experimental Example : Water insolubility  The composition ratio of anti-inflammatory agent (vegetable extract) and Ting  Effect of inhibiting gingival bleeding according to content

<Experimental Method>

The criteria of tooth and tooth surface to be studied were applied in the same way as the gingival index. Bleeding on probing (BOP) was recorded as 1 point if there was bleeding within 10 to 30 seconds after probing and 0 point without bleeding within the gingivitis test.

BOP = sum of total points / total number of teeth examined X 100

<Experimental Results>

The experimental results are shown in Table 3 below. As shown in Examples 1 to 4, it was confirmed that the gingival bleeding index was decreased according to the content and the ratio of the water-insoluble anti-inflammatory agent. Especially, when the ratio of 5: 1: 2 ratio (1: 1: 1: 1: 1: 1) of the extract of Codonopsis lanceolata, Centella asiatica extract and corn starch extract, The highest reduction of the index was observed, showing a synergistic effect on the anti-inflammatory effect at a certain ratio. In Examples 5 to 19, the gingival bleeding index tended to decrease depending on the content and type of tincture, and when the three kinds were mixed, the decrease in gingival bleeding index was more remarkable than in the case of using alone Respectively. Therefore, it was confirmed that the use of a water - insoluble anti - inflammatory agent and a tincture can improve the bleeding index reduction effect by the oral hygiene agent.

Toothpaste group n Baseline After 4 weeks P-value Average Standard Deviation Average Standard Deviation Example 1 30 8.82 2.22 6.82 1.82 Initial <0.001 Example 2 30 8.81 1.89 6.31 1.77 Example 3 31 8.86 1.85 5.86 2.10 Example 4 29 8.88 1.71 5.48 1.52 Example 5 29 8.81 1.73 5.31 1.64 Example 6 30 8.87 1.64 4.87 1.82 Example 7 30 8.86 1.73 4.56 1.54 Example 8 31 8.83 1.84 4.23 1.93 Example 9 31 8.86 1.68 5.36 1.90 Example 10 30 8.86 1.67 4.86 2.15 Example 11 30 8.85 1.95 4.55 1.54 Example 12 30 8.81 1.69 4.21 2.25 Example 13 29 8.80 1.92 5.30 1.95 Example 14 31 8.86 1.93 4.86 1.73 Example 15 31 8.83 1.51 4.53 1.80 Example 16 30 8.85 1.51 4.25 1.55 Example 17 30 8.83 1.51 4.63 1.51 Example 18 30 8.81 1.92 4.61 1.60 Example 19 29 8.84 1.52 4.34 1.90 Comparative Example 1 29 8.83 2.00 8.53 1.61 Comparative Example 2 31 8.88 1.85 8.38 2.11 Comparative Example 3 29 8.81 2.09 8.31 1.72 Comparative Example 4 30 8.82 1.82 8.32 2.22

Claims (9)

An anti-inflammatory oral composition comprising Centella asiatica extract, corn-inhabited extract, and ascidian extract as an active ingredient. [3] The composition according to claim 1, wherein the Centella asiatica extract, corn-inhabited extract and succulent extract are 0.003-0.5 wt% based on the total weight of the composition. The method according to claim 1, wherein the weight ratio of the Centella asiatica extract, the corn-inhabited extract, and the crude extract is 1: 0.5-10: 1 to 20 (Centella asiatica extract: &Lt; / RTI &gt; The composition according to claim 1, wherein the Centella asiatica extract is a solvent extract using water, a lower alcohol, or a mixture thereof as a solvent. 2. The composition according to claim 1, wherein the crude extract is a carbon dioxide supercritical extract. The composition according to claim 1, wherein the composition further comprises a water-soluble plant tincture. 7. The composition according to claim 6, wherein the water-soluble plant tincture is at least one selected from the group consisting of myrrh tincture, lathania tincture, and chamomile tincture. 7. The composition according to claim 6, wherein the water-soluble phytotoxic agent is 0.005 to 3% by weight based on the total weight of the composition. 9. An oral composition for improving periodontal disease comprising the composition according to any one of claims 1 to 8.