KR20100120546A - Composition for preventing and improving inflammation - Google Patents

Abstract

PURPOSE: A composition containing Prunella vulgaris extract for preventing and treating inflammation is provided to suppress prostaglandin E2 and interleukin 1 without side effects. CONSTITUTION: A composition for preventing and treating inflammation contains Prunella vulgaris extract isolated using water, organic solvent or mixture thereof. The organic solvent is methanol, ethanol, acetone, glycerol, propylene glycol or 1,3-butylene glycol. An oral composition for preventing and treating periodontal diseases contains 0.001-20 weight parts of Prunella vulgaris extract as an active ingredient. A cosmetic composition for preventing and treating dermatitis contains 0.001-20 weight parts of Prunella vulgaris extract as an active ingredient.

Description

Composition for preventing and improving inflammation

The present invention relates to a composition for preventing and improving inflammation, and in particular, even when used for a long time while showing an excellent effect on suppressing and alleviating inflammation, including a hachoridae extract that inhibits the production of prostaglandins and interleukins that promote an inflammatory response. It relates to a composition for preventing and improving inflammation that has no side effects and is safe for the human body.

Inflammatory responses are a mechanism of defense, such as an immune response in human tissues or organs against any external stimulus, but can also be accompanied by a disease that is too painful to induce excessive inflammatory responses or require additional medication.

The main chemical delivery mediators that cause inflammatory reactions are amines such as histamine or serotonin, kinin family, prostaglandin, leukotriene, and interlukin. Of these, prostaglandins play a major role in inducing inflammation, and they also weaken the immune response by inhibiting the activity of T and B cells. It is derived from phospholipids, a major component of cell membranes, and is produced through a route of cyclooxygenase from arachidonic acid consisting of 20 carbons. The basic skeleton of prostaglandins is prostanoic acid, which is named PGA, PGB, PGC, PGD, PGE, PGF, PGG, PGH, and PGI, depending on the ring structure in acid. 1,2,3 depending on the number of double bonds in the side chain. Add a number. Prostaglandins that are most involved in the inflammatory response are PGE ₂ , PGI ₂ , TXA ₂ , TXB ₂ (thromboxane), etc. With PGE ₂ PGI ₂ is known to be involved in vascular permeability and thromboxane is involved in leukocyte action. On the other hand, immune cells and leukocytes in the blood secrete trace amounts of bioactive substances and affect other cells when stimulated. This amount of bioactive substance is interleukin. Interleukins are called interleukins because they mediate interactions between white blood cells, but interleukins work on immune cells and leukocytes as well as hematopoietic cells, angiogenesis cells, neurons, endocrine cells, and many other tissue cells. Interleukin-1 (IL-1) is a molecule made mainly by macrophages and monocytes in the blood and is produced by stimulation of antibodies that bind to cellular components or antigens. When acting on T cells, they activate it, causing inflammation of tissue along with other ILs.

Inflammatory reactions caused by these chemical delivery mediators occur throughout human tissues. In particular, tissues such as skin, scalp and oral tissues that are directly exposed to the external environment may have various reaction patterns depending on the extent or type of stimulus. It becomes visible. When inflammatory reactions in the skin, scalp and oral tissues proceed to excessive levels, various types of negative symptoms occur, and research on materials and products that can reduce irritation and minimize inflammation is actively conducted. Conventional anti-inflammatory components such as aspirin and indomethacin have been widely recognized for their effects, but side effects such as gastrointestinal disorders and antivascular expansion are known, and antagonists to neuropeptide-based components including substance P, bradykinin, etc. Although antagonists and cyclooxygenase inhibitors for nin have been suggested, the anti-inflammatory components known to date have been used for their ranges and levels due to legal issues such as safety aspects for humans, stability problems when contained in products, and restrictions on use content. This is limited.

An object of the present invention to solve the above problems is to use for a long time because it contains a substance derived from nature while showing an excellent effect on the suppression and alleviation of inflammation, including the extract of haejucho to inhibit the production of prostaglandins and interleukins that promote the inflammatory response Even if there is no side effect to provide a composition for preventing and improving inflammation.

The present invention to achieve the above object,

It provides a composition for preventing and improving inflammation comprising the extract of haegocho obtained by extraction with water, an organic solvent or a mixture thereof.

The organic solvent may be a polar organic solvent alone or a mixture thereof selected from the group consisting of methanol, ethanol, acetone, glycerol, propylene glycol and 1,3-butylene glycol.

The composition can inhibit the production of prostaglandin E ₂ and interleukin-1.

In order to achieve the other object of the present invention,

It provides a composition for oral cavity prevention and improvement of periodontal disease comprising the extract of Hagocho as an active ingredient.

In order to achieve another object of the present invention,

It provides a composition for the prevention and improvement of scalp hair comprising haegocho extract as an active ingredient.

In order to achieve another object of the present invention,

It provides a cosmetic composition for preventing and improving dermatitis comprising the extract of Hagocho as an active ingredient.

The Hagocho extract may be included in an amount of 0.001 to 20 parts by weight based on 100 parts by weight of the total composition.

The composition for preventing and improving inflammation of the present invention has an excellent effect of reducing or inhibiting inflammation in tissues by inhibiting the production of prostaglandin E ₂ and interleukin-1, and including a substance derived from nature as an active ingredient for a long time when applied to a human body. There is no side effect and it is safe to use.

The composition for oral cavity of the present invention is excellent in the prevention and improvement effect of periodontal disease, including the vinegar extract, there is no side effect even long-term use and can be formulated in various forms.

Hair composition of the present invention is effective in the prevention and improvement of scalpitis, including haegocho extract, there is no irritation to the scalp, there is no side effect even for long-term use and can be formulated in various forms.

The cosmetic composition of the present invention is not only effective in preventing and improving dermatitis, and is not irritating to the skin, and does not cause side effects on the skin even after long-term use.

Hereinafter, the present invention will be described in detail so that those skilled in the art can easily implement the present invention.

Inflammation prevention and improvement composition of the present invention comprises a hyacinth extract. The Hachocho extract is effective in preventing and improving inflammation by inhibiting the production of prostaglandin E ₂ and interleukin-1 that cause inflammation, and is safe for the human body as a substance derived from nature and has no side effects even when used for a long time.

Prunella vulgaris is also called nectar and is a perennial herb. It is native to Korea and Manchuria. It is a perennial herb and grows in mountain fields and roadside grass with a height of 20-30cm. Main stem is square, with white hairs all over, and flowers are often colored. The leaves face each other and have a serrated tooth shape. Ingredients include triterpenoids, oleanolic acid, ursoric acid, rutin, hyperside, caffeic acid, tannin, Contains vitamin B1, vitamin C, vitamin K, and potassium salts. The pharmacological action is potassium salt, triterpenoids, ursonic acid, etc. are diuretic, tannins are astringent.

The vinegar extract may be obtained by extracting various organs or parts of the vinegar, that is, leaves, flowers, fruits, stems, roots, branches and bark. The vinegar extract may be obtained by using various extraction methods known in the art, and preferably may be obtained by extracting various organs or parts of vinegar with an extraction solvent. The extraction solvent may be water, an organic solvent or a mixture thereof. The organic solvent is selected from the group consisting of methanol, ethanol, propanol, isopropanol, butanol, acetone, glycerol, propylene glycol, 1,3-butylene glycol, methyl acetate, ethyl acetate, chloroform, diethyl ether, dichloromethane and hexane It may be selected alone or a mixture thereof, preferably extracted with a polar solvent such as methanol, ethanol, acetone, glycerol, propylene glycol, 1,3-butylene glycol. When extracted with a polar solvent, the production inhibitory effect and solubility of prostaglandin E ₂ and interleukin-1 are superior to those extracted with a nonpolar solvent, and workability in the emulsification step is also improved.

According to an embodiment of the present invention, the edible extract is crushed step (S1); Extraction step (S2); Filtration step (S3); Concentration step S4; And a powdering step (S5).

The crushing step (S1) is a step of crushing hachicho. Although hachocho may be used as it is, it is preferable to use it in powder form by crushing. In the case of crushing into small pieces, the surface area is increased, which may increase the extraction speed and extraction efficiency when extracted with an extraction solvent. In addition, the edible vinegar may be used as it is or dried, and when the dried edible is used, since the moisture is removed, the active ingredient may be extracted at a high concentration. Drying of the edible herbs can be used without limitation methods known in the art. After washing and trimming the vinegar, it can be dried by hot air drying, high temperature drying, natural drying, and the like, and preferably, naturally dried in sunlight.

The extracting step (S2) is a step of extracting the pulverulent crushed in the S1 with an extraction solvent. The extraction method may be a method known in the art such as cold needle extraction, hot water extraction, ultrasonic extraction, reflux cooling extraction, heating extraction. Specifically, the dried vinegar powder powdered in S1 may be extracted by immersion in an extraction solvent for 1 to 5 days at 5 to 80 ° C., and may be repeatedly extracted 2 to 3 times. The extraction solvent is the same as that described above, the amount of the extraction solvent is preferably 2 to 10 times the dry weight of ultrahigh.

The filtration step (S3) is a step of filtering the extract. The filtration may be carried out by a method known in the art, and the extract obtained is usually removed using a filter paper or the like to remove solids, the suspension is centrifuged and the supernatant may be filtered under reduced pressure. The filtration step can be omitted if necessary.

The concentration step (S4) is a step of obtaining a concentrate by concentrating the vinegar extract or filtrate. The concentration can be carried out by a conventional method known in the art, specifically, the filtered extract can be concentrated under reduced pressure at 20 to 100 ℃, preferably 50 to 70 ℃ with a vacuum rotary concentrator.

The powdering step (S5) is a step of powdering the concentrate. The powdering may be performed by conventional methods known in the art, such as lyophilization and spray drying, and a method of lyophilizing to remove moisture is preferable. In addition, the haegocho extract may be used as powdered as described above, it is also possible to use the extract in the liquid state by the extraction solvent as it is or diluted in a solvent.

The edible extract of the present invention is included in the present invention as long as it exhibits substantially the same effect using the above-described extracting solvent as well as other extracting solvents, and the edible extract is not only extracted by the extracting solvent, but also conventional purification It also includes processed extracts. Specifically, the hachocho extract of the present invention may be used as it is or as an extract using an extraction solvent, followed by purification, for example, membrane separation, size, charge, hydrophobicity or affinity using a filtration membrane having a cut-off value at a constant molecular weight. Purification process, such as separation by a variety of chromatography for separation according to the additional can be used.

The Hagocho extract may be included in an amount of 0.001 to 20 parts by weight based on 100 parts by weight of the total composition. When included within the above range, the effect of preventing and improving inflammation is excellent, and even if used for a long time, side effects are small.

The present invention provides a composition for preventing and improving periodontal disease comprising the edible extract as an active ingredient. Bacterial antigens, represented by endotoxin or lipopolysaccharide (LPS) from the plaque, invade the gingival tissue, whereby the neutrophils and macrophages induce prostaglandin E ₂ and interleukin-1 Release. The Hachocho extracts are effective in preventing and improving periodontal disease by inhibiting the production of prostaglandins E ₂ and interleukin-1, which are inflammation-inducing substances released by neutrophils and macrophages, thereby improving softening and tearing of gingival tissues, and continuous bleeding. can do. It is also harmless to the oral mucosa.

The Hagocho extract may be included in an amount of 0.001 to 20 parts by weight based on 100 parts by weight of the total composition. Preferably it may be included in 0.5 to 20 parts by weight. If it is included less than 0.001 parts by weight of the prevention and improvement effect of periodontal disease is insignificant, if it is included more than 20 parts by weight may have difficulty in formulating and may be difficult to secure long-term stability of the product.

The oral composition for preventing and improving periodontal disease may be prepared in any shape such as paste, solid, liquid, or gum. Specific formulations include toothpaste, tooth powder, jelly, caramel, candy, oral rinse, mouthwash, gum, and the like.

The composition for oral cavity for preventing and improving periodontal disease may include other components commonly used within the range not impairing the object of the present invention in addition to the haphwanpi extract. For example, an aqueous component, an oily component, surfactant, a humectant, a thickener, a preservative fragrance, a pigment | dye, etc. can be included. Specifically, when the composition for oral cavity is a toothpaste, abrasives such as alumina, silica gel, precipitated silica, calcium carbonate, calcium dihydrogen phosphate, sodium bicarbonate, etc. which are typically contained in toothpaste; Wetting agents, such as sorbitol, glycerin, polyethylene glycols; Foaming agents such as sodium lauryl sulfate, sodium lauryl sarcosinate, dodecylbenzenesulfonate and the like; Binders such as carboxymethyl cellulose, carrageenan, polyacrylate, and the like; Sweetening agents such as saccharin, aspartame, stevioside and the like; Preservatives such as methyl paraoxybenzoate and propyl paraoxybenzoate; Medicinal agents such as sodium fluoride, sodium fluoride phosphate, vitamins, salts and the like; Spices; Pigments; And pH adjusters.

The present invention provides a cosmetic composition for the prevention and improvement of dermatitis comprising the edible extract as an active ingredient. When exposed to excessive ultraviolet rays or contaminants, the skin tissue causes skin irritation and inflammatory reactions such as erythema, edema, tingling, and itching. Substances such as sebum, sweat, and external skin products such as surfactants, fatty acids, higher alcohols, and proteins in the body may be broken down by skin flora and converted into highly toxic substances, thereby inducing an inflammatory response. have. Inflammatory reactions in the skin also show physiological phenomena such as vasodilation, changes in blood flow, and infiltration of leukocytes in tissues, resulting in symptoms such as redness, fever, swelling, and pain, as well as increased vascular permeability with antibodies, complement and macrophages. Focusing on the back of the inflamed area can also cause erythema. Since the extract of Hagocho has the effect of inhibiting the production of prostaglandin E ₂ and interleukin-1, which are inflammation-causing substances, it is effective in preventing and alleviating inflammation occurring in the skin, and is safe for the human body as a substance derived from nature. There are no side effects.

The hacho fruit extract may be included in an amount of 0.001 to 20 parts by weight based on 100 parts by weight of the total composition. Preferably it may be included in 0.5 to 20 parts by weight. If it is included less than 0.001 parts by weight it is difficult to achieve the object of the present invention, if it contains more than 20 parts by weight may be difficult to formulate and the feeling of the cosmetic composition may be reduced due to the fragrance of the vinegar extract itself.

The cosmetic composition for preventing and improving dermatitis may be variously formulated into flexible lotion, nourishing lotion, nourishing cream, massage cream, essence, pack, and the like. In addition, the cosmetic composition for preventing and improving dermatitis may be combined with components conventionally used in cosmetics within the scope of not impairing the object of the present invention in addition to the hapilpi extract.

The present invention provides a hair composition for preventing and improving scalp infection comprising the edible extract as an active ingredient. The Hachocho extract is effective in preventing and improving scalpitis by inhibiting the production of prostaglandin E ₂ and interleukin-1, which are inflammation causing substances. In addition, the hair composition for preventing and improving scalp infection has no irritation to the scalp and no side effects even when used for a long time.

The hacho fruit extract may be included in an amount of 0.001 to 20 parts by weight in dry weight based on 100 parts by weight of the total composition. Preferably it may be included in 0.5 to 20 parts by weight. When included in less than 0.001 parts by weight it is difficult to achieve the object of the present invention, when included in more than 20 parts by weight may be difficult to formulate and may be difficult to ensure long-term stability of the product.

The composition for the prevention and improvement of the scalp infection is prepared and used in formulations such as supple cosmetics, nourishing cosmetics, nutrition cream, massage cream, essence, pack, hair tonic, hair lotion, shampoo, rinse, treatment, etc. If necessary, together with the components generally used in the composition for hair within the range that does not impair the effects of the present invention, for example, with an aqueous component, an oily component, a surfactant, a humectant, a thickener, a fragrance, a pigment, etc. It can mix.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. This is for the purpose of illustrating the invention only, and thus the scope of the invention is not limited.

Example 1 Preparation of Haechocho Extract

2 g of ethanol (95%) was added to 100 g of powdered and dried pulverized vinegar, and the mixture was immersed at room temperature for 3 to 4 days, repeatedly extracted and filtered. The filtrate was distilled under reduced pressure and concentrated to extract 24.3 g. A concentrate was obtained. This concentrate was dissolved in 10% DMSO solution and used for the evaluation.

<Examples 2 to 5> Preparation of the mouthwash

Oral cleansing agent containing Hachocho extract prepared in Example 1 was prepared by a conventional method known in the art in the composition of Table 1. The unit in Table 1 is parts by weight.

Example 6 Preparation of Toothpaste

Toothpaste comprising the haegocho extract prepared in Example 1 was prepared by a conventional method known in the art in the composition shown in Table 2.

Example 7 Preparation of Gum

The gum containing the edible extract of Example 1 was prepared by a conventional method known in the art in the composition of Table 3 below.

Example 8 Preparation of Cream

The cream containing the Hagocho extract prepared in Example 1 was prepared by a conventional method known in the art with the composition of Table 4 below.

Example 9 Preparation of Lotion

The lotion containing the hawthorn extract prepared in Example 1 was prepared by a conventional method known in the art with the composition of Table 5 below.

Examples 10 to 13 Preparation of Hair Essence

The hair essence comprising the hacho extract of Example 1 was prepared by a conventional method known in the art in the composition of Table 6 below. The unit in Table 6 is parts by weight.

Example 14 Preparation of Shampoo

Shampoo comprising the haegocho extract prepared in Example 1 was prepared by a conventional method known in the art in the composition of Table 7.

Comparative Examples 1 and 2 Preparation of Mouthwashes

To prepare a mouthwash in a conventional manner known in the art in the composition of Table 8. The units in Table 8 below are parts by weight.

Comparative Examples 3 to 4 Preparation of Hair Essence

To prepare a hair essence in the conventional manner known in the art in the composition of Table 9. The unit in Table 9 is parts by weight.

Experimental Example 1 PGE of Hachocho extract ₂  Generation suppression evaluation

PGE ₂ production inhibition assay was performed using a commercially available quantitative assay kit (US R & D system). Cell lines (HaCaT) were incubated in a 6-well microplate at about 1.0-4.0 × 10 ⁵ / well, and then treated with sodium dodecyl sulfate (SDS) at a concentration of 0.003% as a stimulant and an evaluation sample was injected into each well. After 48 hours, 300 µl of the culture solution was collected from each well, and the amount of PGE ₂ produced was quantitatively evaluated at 450 nm according to the method of the assay kit. At this time, the control (control) means a culture solution recovered from the well treated only the stimulus material, 10% DMSO solution was also included in the quantitative evaluation in order to confirm the effect of the 10% DMSO solution used to dissolve the vinegar extract. Hagicho extract was used in prepared in Example 1, was injected at a concentration of 1%. The evaluation results are expressed in relative values based on the amount of PGE ₂ produced from the culture solution obtained from the well treated with 10 mg / ml of indomethacin, which is widely used as an anti-inflammatory component. The results are shown in Table 10 below.

An antibody capable of PGE ₂ and the complementary coupling in combination with the PGE ₂ contained in the cell culture medium recovered at each well PGE ₂ - Since the principle of generating an antibody complex, and detecting the substance at a particular wavelength in the above Table 10 OD The smaller the value, the more suppressed the PGE ₂ production. As shown in Table 10, the Hachocho extract showed an excellent anti-inflammatory effect almost close to the inhibitory effect of PGE ₂ production of indomethacin, a conventional anti-inflammatory component.

Experimental Example 2 Evaluation of Inhibition of IL-1α Production by Herb Extracts

The inhibition of IL-1α production was also performed using a commercially available quantitative assay kit (US R & D system). Cell lines (HaCaT) were incubated in a 6-well microplate at 1.0-4.0 × 10 ⁵ / well, then treated with SDS at a concentration of 0.003% as a stimulant and an evaluation sample was injected into each well. After 48 hours, 300 μl of the culture solution was recovered from each well, and IL-1α production was quantitatively evaluated at 450 nm according to the method of the assay kit. In this case, the positive control means a culture of wells that have not been treated with any, and the negative control means a culture recovered from wells that have only been treated with a stimulus, and the 10% DMSO solution used to dissolve the vinegar extract. A 10% DMSO solution was also included in the quantitative evaluation to confirm the effect. Hachocho extract was used in the extract prepared in Example 1 and diluted to a concentration of 1%. Unlike the PGE ₂ evaluation, the IL-1α evaluation was determined by comparing the absorbance values themselves measured at 450 nm with each other, since a commonly used inhibitor component is not known. The results are shown in Table 11 below.

Since the antibody capable of complementarily binding to IL-1α binds to IL-1α contained in the cell culture solution recovered from each well, the IL-1α-antibody complex is detected and the substance is detected at a specific wavelength. The smaller the OD value of 11, the more inhibited IL-1α production. As shown in Table 11, Hachocho extract showed an amount of IL-1α produced almost close to the untreated comparison group without any component. Therefore, it can be seen that the Hagocho extract of the present invention has an effect of inhibiting IL-1α production.

Experimental Example 3 PGE of Mouthwashes and Hair Essences ₂  Generation suppression evaluation

Inhibition evaluation of PGE ₂ production of the compositions of Examples 2 to 5, 10 to 13 and Comparative Examples 1 to 4 was performed. Evaluation was carried out in the same manner as in Experiment 1. Each composition was diluted to 10% concentration using a cell culture and then used for evaluation. The evaluation results are shown in the same manner as in Experimental Example 1 based on the degree of inhibition of PGE ₂ production of indomethacin used as a comparative sample. The results are shown in Table 12 below.

According to the above Table 12, the composition containing the haejucho extract of the present invention was superior to the PGE ₂ production inhibitory effect compared to the composition of Comparative Example 1 or 3 that does not contain it. The reason why the example including the Hagocho extract of the present invention was not superior to the inhibitory effect of PGE ₂ production was shown to be due to the effect of DMSO, a buffer solution.

On the other hand, it can be seen that the composition of Comparative Example 2 or 4 containing an excess of Hachocho extract of the present invention may be difficult to formulate because it is not dissolved in a uniform solution.

Experimental Example 4 Evaluation of Inhibition of IL-1α Production of Mouthwashes and Hair Essences

The inhibition of IL-1α production of the compositions of Examples 2-5, 10-13 and Comparative Examples 1-4 was evaluated. Evaluation was carried out in the same manner as in Experiment 2. Each composition was diluted to 10% concentration using a cell culture and then used for evaluation. Evaluation was carried out by measuring the absorbance at 450nm, as in Experimental Example 2, the results are shown in Table 13 below.

According to the above Table 13, Examples 2 to 5 and 10 to 13 which is a composition comprising the edible extract of the present invention is better than IL-1α production inhibitory effect than Comparative Example 1 or 3 does not contain a edible extract Can be.

Experimental Example 5 Validation of Human Stability through Cytotoxicity Evaluation

The MTT assay, which is generally used for toxicity evaluation, was used to evaluate human safety of Hagocho extract. After preparing the haejucho extract prepared in Example 1 with 10% DMSO solution and dissolved again in PBS solution, haejucho extract sample solutions of various concentrations were prepared through step dilution. Each well of the 96-well microplate was inoculated with an appropriate amount of cell line (HaCaT) and an evaluation sample (1-4 × 10 ⁴ cells / ml) and incubated for 2 days at 37 ° C. and 5% CO ₂ . 0.1 mg of MTT was added to all wells and incubated at 37 ° C. for 4 hours. Plates were gently centrifuged, then the medium in each well was removed and DMSO solution was added and gently shaken for 10 minutes until the resulting formazan crystals dissolved. Absorbance was measured on a microplate reader (540 nm). The results obtained by measuring the absorbance according to the concentrations of the Prunella vulgaris extract and DMSO and PBS solutions are shown in FIG. 1.

The absorbance of FIG. 1 represents the amount of MTT decomposed into cells by formazan (blue) and is proportional to the number of living cells in each well. According to Figure 1, the Hagocho extract showed a level of cytotoxicity almost close to the PBS solution used as a buffer solution at a concentration of about 1%. In addition, when the safety level of the DMSO solution used to dissolve the haegocho extract is significantly lowered from 0.125% concentration, the human safety value of the haegocho extract itself is expected to be higher than the above result. From the above results, it is expected that the safety of the oral cavity, the scalp and the skin will be excellent when the hachocho extract is used in combination with various compositions as described above.

As described above, the edible extract of the present invention has the effect of alleviating and improving inflammation in tissues by inhibiting the production of PGE ₂ and IL-1. Therefore, the haegocho extract may be included in the composition for oral cavity to prevent periodontal disease, and may be included in the cosmetic composition or hair composition to improve dermatitis or scalpitis. In addition, the haegocho extract is a natural-derived material that is safe for the human body and has no irritation to the skin, oral mucosa or scalp, and has no side effects even when used for a long time.

1 is a graph showing the cytotoxicity evaluation results of the extract of Hagocho extract according to an embodiment of the present invention.

Claims (7)

Inflammation prevention and improvement composition comprising the extract of haegocho obtained by extraction with water, an organic solvent or a mixture thereof. The method of claim 1, The composition for preventing and improving inflammation, characterized in that the composition inhibits the production of prostaglandin E ₂ and interleukin-1. The method of claim 1, The composition for preventing and improving inflammation, characterized in that the organic solvent is a polar organic solvent alone or a mixture thereof selected from the group consisting of methanol, ethanol, acetone, glycerol, propylene glycol and 1,3-butylene glycol. The method of claim 1, The composition for preventing and improving inflammation, characterized in that the edible extract is contained in an amount of 0.001 to 20 parts by weight based on 100 parts by weight of the total composition. Oral composition for preventing and improving periodontal disease, characterized in that the extract contains 0.001 to 20 parts by weight as an active ingredient. Cosmetic composition for preventing and improving dermatitis, characterized in that the extract contains 0.001 to 20 parts by weight as an active ingredient. Hair composition for preventing and improving scalp infection, characterized in that it comprises 0.001 to 20 parts by weight as an active ingredient.

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