KR20170122799A - TGF-β 억제제 - Google Patents

TGF-β 억제제 Download PDF

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Publication number
KR20170122799A
KR20170122799A KR1020177027381A KR20177027381A KR20170122799A KR 20170122799 A KR20170122799 A KR 20170122799A KR 1020177027381 A KR1020177027381 A KR 1020177027381A KR 20177027381 A KR20177027381 A KR 20177027381A KR 20170122799 A KR20170122799 A KR 20170122799A
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South Korea
Prior art keywords
alkyl
imidazol
imidazo
haloalkyl
pyridine
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Korean (ko)
Inventor
토드 킨셀라
마리나 젤먼
후이 홍
이하브 에스. 다르위쉬
라진데르 싱
지아신 유
로버트 엠. 보르질레리
우펜더 벨라파르티
페이잉 리우
체탄 다르네
하시부르 라하만
자야쿠마르 산카라 와리에르
Original Assignee
리겔 파마슈티칼스, 인크.
브리스톨-마이어스 스큅 컴퍼니
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Publication of KR20170122799A publication Critical patent/KR20170122799A/ko
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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KR1020177027381A 2015-03-02 2016-02-26 TGF-β 억제제 Ceased KR20170122799A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562127109P 2015-03-02 2015-03-02
US62/127,109 2015-03-02
PCT/US2016/019830 WO2016140884A1 (en) 2015-03-02 2016-02-26 TGF-β INHIBITORS

Publications (1)

Publication Number Publication Date
KR20170122799A true KR20170122799A (ko) 2017-11-06

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ID=55543068

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Application Number Title Priority Date Filing Date
KR1020177027381A Ceased KR20170122799A (ko) 2015-03-02 2016-02-26 TGF-β 억제제

Country Status (23)

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US (3) US9884868B2 (enExample)
EP (1) EP3265454B1 (enExample)
JP (1) JP6836998B2 (enExample)
KR (1) KR20170122799A (enExample)
CN (1) CN107406412B (enExample)
AR (1) AR103828A1 (enExample)
AU (1) AU2016226468B2 (enExample)
BR (1) BR112017017135A2 (enExample)
CA (1) CA2973602A1 (enExample)
CL (1) CL2017002207A1 (enExample)
CO (1) CO2017009891A2 (enExample)
EA (1) EA037112B1 (enExample)
ES (1) ES2789331T3 (enExample)
IL (1) IL254187A0 (enExample)
MX (1) MX371167B (enExample)
MY (1) MY186133A (enExample)
PE (1) PE20171789A1 (enExample)
PH (1) PH12017501326A1 (enExample)
SG (1) SG11201705821XA (enExample)
TN (1) TN2017000374A1 (enExample)
TW (1) TW201639827A (enExample)
WO (1) WO2016140884A1 (enExample)
ZA (1) ZA201705527B (enExample)

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WO2023008936A1 (ko) * 2021-07-28 2023-02-02 주식회사 티움바이오 종양 예방 또는 치료용 약학 조성물 및 이의 용도
WO2025063820A1 (ko) * 2023-09-21 2025-03-27 오토텔릭바이오 주식회사 티아졸 유도체 화합물을 포함하는 폐섬유화증 치료용 조성물
WO2025206749A1 (ko) * 2024-03-27 2025-10-02 동국대학교 산학협력단 신규 옥사졸 유도체 및 이를 포함하는 암 예방 또는 치료용 조성물

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JP6836998B2 (ja) 2015-03-02 2021-03-03 ライジェル ファーマシューティカルズ， インコーポレイテッド ＴＧＦ−β阻害剤
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
CA3045947A1 (en) * 2016-12-08 2018-06-14 Michael J. Soth Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease
US10961239B2 (en) 2017-01-05 2021-03-30 Bristol-Myers Squibb Company TGF beta receptor antagonists
US11040027B2 (en) 2017-01-17 2021-06-22 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
ES3053505T3 (en) * 2017-03-23 2026-01-22 Clavius Pharmaceuticals Llc Tri-substituted imidazoles for the inhibition of tgf beta and methods of treatment
CN109293652B (zh) * 2017-07-24 2021-10-22 四川科伦博泰生物医药股份有限公司 一种取代的噻唑衍生物及其用途
GB201718285D0 (en) 2017-11-03 2017-12-20 Discuva Ltd Antibacterial Compounds
ES2918448T3 (es) 2018-03-29 2022-07-15 Univ Masarykova 4-(1H-Imidazol-5-il)-1H-pirrolo [2,3-b]piridinas para su uso en el tratamiento de leucemias, linfomas y tumores sólidos
KR102891320B1 (ko) 2018-07-11 2025-11-28 스칼러 락, 인크. 고친화도, 이소형-선택적 TGFβ1 억제제 및 그의 용도
WO2020041562A1 (en) 2018-08-22 2020-02-27 Clavius Pharmaceuticals, Llc Substituted imidazoles for the inhibition of tgf-beta and methods of treatment
CA3117710A1 (en) * 2018-12-11 2020-06-18 Theravance Biopharma R&D Ip, Llc Alk5 inhibitors
CN111825658B (zh) * 2019-04-18 2024-11-08 华东理工大学 Egfr三突变抑制剂及其应用
US11560366B2 (en) 2019-10-21 2023-01-24 Board Of Regents, The University Of Texas System Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease
KR20220104208A (ko) * 2019-11-22 2022-07-26 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Alk5 억제제로서 치환된 1,5-나프티리딘 또는 퀴놀린
CN114981298B (zh) 2019-12-12 2024-08-20 听治疗有限责任公司 用于预防和治疗听力损失的组合物和方法
WO2021138391A1 (en) 2019-12-30 2021-07-08 Tyra Biosciences, Inc. Indazole compounds
CN116323607A (zh) * 2020-06-10 2023-06-23 施万生物制药研发Ip有限责任公司 用作alk5抑制剂的萘啶衍生物
CN112321592B (zh) * 2020-11-12 2022-03-04 山东省科学院菏泽分院 一种6-氯咪唑并[1,2-b]哒嗪-3-甲腈的合成方法
WO2022251359A1 (en) * 2021-05-26 2022-12-01 Theravance Biopharma R&D Ip, Llc Bicyclic inhibitors of alk5 and methods of use
KR20260019479A (ko) 2023-05-04 2026-02-10 레볼루션 메디슨즈, 인크. Ras 관련 질환 또는 장애를 위한 병용 요법
AU2023449764A1 (en) * 2023-05-22 2025-12-11 Iregene Therapeutics Co., Ltd. Pyrazolecarbonyl piperazinone compound, pharmaceutical composition and use thereof
CN121889155A (zh) 2023-08-07 2026-04-17 锐新医药公司 用于治疗ras蛋白相关疾病或病症的rmc-6291
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
CN117899085A (zh) * 2023-12-27 2024-04-19 无锡市南京大学锡山应用生物技术研究所 用于提升全层皮肤移植成功率的药物组合物和药物制剂及其用途
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