KR20170110716A - 크로마토그래피 적용에서 스웹 및 데드 볼륨을 최소화하는 수단 및 방법 - Google Patents

크로마토그래피 적용에서 스웹 및 데드 볼륨을 최소화하는 수단 및 방법 Download PDF

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Publication number
KR20170110716A
KR20170110716A KR1020177025025A KR20177025025A KR20170110716A KR 20170110716 A KR20170110716 A KR 20170110716A KR 1020177025025 A KR1020177025025 A KR 1020177025025A KR 20177025025 A KR20177025025 A KR 20177025025A KR 20170110716 A KR20170110716 A KR 20170110716A
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South Korea
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column
less
chromatographic
post
fraction
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English (en)
Korean (ko)
Inventor
닐스 쿨라크
마티아스 만
Original Assignee
막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우.
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Publication of KR20170110716A publication Critical patent/KR20170110716A/ko
Withdrawn legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/24—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the treatment of the fractions to be distributed
    • B01D15/247—Fraction collectors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N2030/6013—Construction of the column end pieces interfaces to detectors

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020177025025A 2015-02-09 2016-02-05 크로마토그래피 적용에서 스웹 및 데드 볼륨을 최소화하는 수단 및 방법 Withdrawn KR20170110716A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15154374 2015-02-09
EP15154374.1 2015-02-09
PCT/EP2016/052490 WO2016128316A1 (en) 2015-02-09 2016-02-05 Means and methods for minimizing swept and dead volumes in chromatographic applications

Publications (1)

Publication Number Publication Date
KR20170110716A true KR20170110716A (ko) 2017-10-11

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177025025A Withdrawn KR20170110716A (ko) 2015-02-09 2016-02-05 크로마토그래피 적용에서 스웹 및 데드 볼륨을 최소화하는 수단 및 방법

Country Status (8)

Country Link
US (1) US20180031528A1 (https=)
EP (1) EP3256846A1 (https=)
JP (1) JP2018508793A (https=)
KR (1) KR20170110716A (https=)
CN (1) CN107209155A (https=)
AU (1) AU2016218072A1 (https=)
CA (1) CA2975027A1 (https=)
WO (1) WO2016128316A1 (https=)

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RU2729116C2 (ru) 2015-12-16 2020-08-04 Гритстоун Онколоджи, Инк. Идентификация, производство и применение неоантигенов
KR20260039788A (ko) 2017-10-10 2026-03-20 시애틀 프로젝트 코포레이션 핫스팟을 이용한 신생항원 동정
CA3083097A1 (en) 2017-11-22 2019-05-31 Gritstone Oncology, Inc. Reducing junction epitope presentation for neoantigens
US20190227040A1 (en) * 2018-01-22 2019-07-25 Thermo Finnigan Llc Method and Apparatus for Chromatograph Nano-Flow Fractionator
CN112034083B (zh) * 2020-07-30 2023-03-31 北京卫星制造厂有限公司 一种液相色谱泵流路超低死体积的标定方法及系统

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH037815Y2 (https=) * 1984-10-05 1991-02-26
US5305788A (en) * 1992-08-13 1994-04-26 Whitey Co. Stream selector for process analyzer
FR2809490B1 (fr) * 2000-05-23 2002-11-29 Hocer Installation et procede pour la preparation automatique d'echantillons
US6748975B2 (en) * 2001-12-26 2004-06-15 Micralyne Inc. Microfluidic valve and method of manufacturing same
WO2005114168A1 (en) * 2004-05-22 2005-12-01 Agilent Technologies, Inc. Combi column
US8123949B2 (en) * 2005-01-20 2012-02-28 Waters Technologies Corporation Methods for separating compounds
CN2859526Y (zh) * 2005-07-28 2007-01-17 上海烟草（集团）公司 一种大孔径柱到毛细柱的多维气相色谱系统
WO2007052223A2 (en) * 2005-11-01 2007-05-10 The Procter & Gamble Company Multi-phase personal care composition comprising a depositing perfume
US20110232373A1 (en) * 2008-12-04 2011-09-29 Vrije Universiteit Brussel Chromatographic separation device with variable length and a method for its use
US8656955B2 (en) * 2010-05-20 2014-02-25 Bio-Rad Laboratories, Inc. Rotary column selector valve
EP2596134B1 (en) * 2010-07-23 2020-04-08 President and Fellows of Harvard College Methods of detecting diseases or conditions using phagocytic cells
CN203935755U (zh) * 2010-09-22 2014-11-12 魄金莱默保健科学有限公司 用于色谱的反冲系统和装置
GB2491168B (en) * 2011-05-26 2014-09-10 Thermo Electron Mfg Ltd Method and apparatus for improved resolution chromatography
GB2491169B (en) * 2011-05-26 2014-09-10 Thermo Electron Mfg Ltd Method and apparatus for improved resolution chromatography
US20140138312A1 (en) * 2011-06-09 2014-05-22 Waters Technologies Corporation Reducing Dispersion Due To Vias In Planar Microfluidic Separation Devices
HUP1100312A2 (en) * 2011-06-14 2013-01-28 Emil Dr Mincsovics Procedure and equipment for improving of performance characteristics of column chromatography separation processes
CN203060889U (zh) * 2012-12-19 2013-07-17 大连依利特分析仪器有限公司 液相色谱用全自动制备级馏分收集阀站

Also Published As

Publication number Publication date
EP3256846A1 (en) 2017-12-20
WO2016128316A1 (en) 2016-08-18
JP2018508793A (ja) 2018-03-29
CN107209155A (zh) 2017-09-26
CA2975027A1 (en) 2016-08-18
US20180031528A1 (en) 2018-02-01
AU2016218072A1 (en) 2017-08-24

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PA0105 International application

Patent event date: 20170906

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination