AU2016218072A1 - Means and methods for minimizing swept and dead volumes in chromatographic applications - Google Patents

Means and methods for minimizing swept and dead volumes in chromatographic applications Download PDF

Info

Publication number
AU2016218072A1
AU2016218072A1 AU2016218072A AU2016218072A AU2016218072A1 AU 2016218072 A1 AU2016218072 A1 AU 2016218072A1 AU 2016218072 A AU2016218072 A AU 2016218072A AU 2016218072 A AU2016218072 A AU 2016218072A AU 2016218072 A1 AU2016218072 A1 AU 2016218072A1
Authority
AU
Australia
Prior art keywords
column
less
fractions
chromatographic
chromatography step
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2016218072A
Other languages
English (en)
Inventor
Nils KULAK
Matthias Mann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Publication of AU2016218072A1 publication Critical patent/AU2016218072A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/24—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the treatment of the fractions to be distributed
    • B01D15/247—Fraction collectors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N2030/6013—Construction of the column end pieces interfaces to detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2016218072A 2015-02-09 2016-02-05 Means and methods for minimizing swept and dead volumes in chromatographic applications Abandoned AU2016218072A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15154374 2015-02-09
EP15154374.1 2015-02-09
PCT/EP2016/052490 WO2016128316A1 (en) 2015-02-09 2016-02-05 Means and methods for minimizing swept and dead volumes in chromatographic applications

Publications (1)

Publication Number Publication Date
AU2016218072A1 true AU2016218072A1 (en) 2017-08-24

Family

ID=52686078

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016218072A Abandoned AU2016218072A1 (en) 2015-02-09 2016-02-05 Means and methods for minimizing swept and dead volumes in chromatographic applications

Country Status (8)

Country Link
US (1) US20180031528A1 (https=)
EP (1) EP3256846A1 (https=)
JP (1) JP2018508793A (https=)
KR (1) KR20170110716A (https=)
CN (1) CN107209155A (https=)
AU (1) AU2016218072A1 (https=)
CA (1) CA2975027A1 (https=)
WO (1) WO2016128316A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2729116C2 (ru) 2015-12-16 2020-08-04 Гритстоун Онколоджи, Инк. Идентификация, производство и применение неоантигенов
KR20260039788A (ko) 2017-10-10 2026-03-20 시애틀 프로젝트 코포레이션 핫스팟을 이용한 신생항원 동정
CA3083097A1 (en) 2017-11-22 2019-05-31 Gritstone Oncology, Inc. Reducing junction epitope presentation for neoantigens
US20190227040A1 (en) * 2018-01-22 2019-07-25 Thermo Finnigan Llc Method and Apparatus for Chromatograph Nano-Flow Fractionator
CN112034083B (zh) * 2020-07-30 2023-03-31 北京卫星制造厂有限公司 一种液相色谱泵流路超低死体积的标定方法及系统

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH037815Y2 (https=) * 1984-10-05 1991-02-26
US5305788A (en) * 1992-08-13 1994-04-26 Whitey Co. Stream selector for process analyzer
FR2809490B1 (fr) * 2000-05-23 2002-11-29 Hocer Installation et procede pour la preparation automatique d'echantillons
US6748975B2 (en) * 2001-12-26 2004-06-15 Micralyne Inc. Microfluidic valve and method of manufacturing same
WO2005114168A1 (en) * 2004-05-22 2005-12-01 Agilent Technologies, Inc. Combi column
US8123949B2 (en) * 2005-01-20 2012-02-28 Waters Technologies Corporation Methods for separating compounds
CN2859526Y (zh) * 2005-07-28 2007-01-17 上海烟草（集团）公司 一种大孔径柱到毛细柱的多维气相色谱系统
WO2007052223A2 (en) * 2005-11-01 2007-05-10 The Procter & Gamble Company Multi-phase personal care composition comprising a depositing perfume
US20110232373A1 (en) * 2008-12-04 2011-09-29 Vrije Universiteit Brussel Chromatographic separation device with variable length and a method for its use
US8656955B2 (en) * 2010-05-20 2014-02-25 Bio-Rad Laboratories, Inc. Rotary column selector valve
EP2596134B1 (en) * 2010-07-23 2020-04-08 President and Fellows of Harvard College Methods of detecting diseases or conditions using phagocytic cells
CN203935755U (zh) * 2010-09-22 2014-11-12 魄金莱默保健科学有限公司 用于色谱的反冲系统和装置
GB2491168B (en) * 2011-05-26 2014-09-10 Thermo Electron Mfg Ltd Method and apparatus for improved resolution chromatography
GB2491169B (en) * 2011-05-26 2014-09-10 Thermo Electron Mfg Ltd Method and apparatus for improved resolution chromatography
US20140138312A1 (en) * 2011-06-09 2014-05-22 Waters Technologies Corporation Reducing Dispersion Due To Vias In Planar Microfluidic Separation Devices
HUP1100312A2 (en) * 2011-06-14 2013-01-28 Emil Dr Mincsovics Procedure and equipment for improving of performance characteristics of column chromatography separation processes
CN203060889U (zh) * 2012-12-19 2013-07-17 大连依利特分析仪器有限公司 液相色谱用全自动制备级馏分收集阀站

Also Published As

Publication number Publication date
EP3256846A1 (en) 2017-12-20
WO2016128316A1 (en) 2016-08-18
KR20170110716A (ko) 2017-10-11
JP2018508793A (ja) 2018-03-29
CN107209155A (zh) 2017-09-26
CA2975027A1 (en) 2016-08-18
US20180031528A1 (en) 2018-02-01

Similar Documents

Publication Publication Date Title
US20180031528A1 (en) Means and methods for minimizing swept and dead volumes in chromatographic applications
AU2012260982B2 (en) Method and apparatus for improved resolution chromatography
CN104903721B (zh) I相和ii相代谢物以及母体化合物的分析
CN103212217B (zh) 高丰度蛋白质去除的二维常规柱阵列式色谱分离系统及分离方法
AU2012260982A1 (en) Method and apparatus for improved resolution chromatography
US20050214130A1 (en) Multidimensional pump apparatus and method for fully automated complex mixtures separation, identification, and quantification
AU2012260981B2 (en) Method and apparatus for improved resolution chromatography
CN101464430B (zh) 一种内源性多肽在线富集和自动化分析的方法及专用装置
US20120298585A1 (en) Method and apparatus for improved resolution chromatography
AU2012260981A1 (en) Method and apparatus for improved resolution chromatography
CN101206197B (zh) 双分流纳升级液相色谱在线脱盐、富集与质谱联用系统
CN101206205B (zh) 微流量液相色谱在线大体积进样的方法和专用装置
US10252185B2 (en) Method and apparatus for reaction chromatography
US10092858B2 (en) Method and apparatus for improved resolution chromatography
JP2009294118A (ja) 生体試料分離方法，生体試料検出方法，生体試料分離システム及び生体試料分離・検出システム
TWI761660B (zh) 雙重管柱lc-ms系統及其使用方法
CN105891363A (zh) 一种多探头液质联用点板装置
Gil et al. Automated analysis of mouse serum peptidome using restricted access media and nanoliquid chromatography–tandem mass spectrometry
CN215641057U (zh) 三泵三阀液相色谱仪
JP4498186B2 (ja) 液体クロマトグラフ分析方法及び装置
CN110031563B (zh) 一种气相色谱仪-质谱仪分时复用接口装置和检测方法
Slysz et al. Integrating accelerated tryptic digestion into proteomics workflows
CN106501428A (zh) 一种分步聚焦‑轴向混合‑高效液相色谱分离系统的联用方法
CN103323544A (zh) 整体蛋白质在线分级预分离和分离分析方法及其液相色谱系统
Schroeder et al. Automated parallel chromatographic separations in process development, in-process monitoring and validation of biopharmaceutical production

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period