CN107209155A - 用于最小化色谱应用中扫掠和死体积的装置和方法 - Google Patents

用于最小化色谱应用中扫掠和死体积的装置和方法 Download PDF

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Publication number
CN107209155A
CN107209155A CN201680009475.4A CN201680009475A CN107209155A CN 107209155 A CN107209155 A CN 107209155A CN 201680009475 A CN201680009475 A CN 201680009475A CN 107209155 A CN107209155 A CN 107209155A
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chromatography step
column
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CN201680009475.4A
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Chinese (zh)
Inventor
N·库拉克
M·曼
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Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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Publication of CN107209155A publication Critical patent/CN107209155A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/24—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the treatment of the fractions to be distributed
    • B01D15/247—Fraction collectors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N2030/6013—Construction of the column end pieces interfaces to detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201680009475.4A 2015-02-09 2016-02-05 用于最小化色谱应用中扫掠和死体积的装置和方法 Pending CN107209155A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15154374 2015-02-09
EP15154374.1 2015-02-09
PCT/EP2016/052490 WO2016128316A1 (en) 2015-02-09 2016-02-05 Means and methods for minimizing swept and dead volumes in chromatographic applications

Publications (1)

Publication Number Publication Date
CN107209155A true CN107209155A (zh) 2017-09-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680009475.4A Pending CN107209155A (zh) 2015-02-09 2016-02-05 用于最小化色谱应用中扫掠和死体积的装置和方法

Country Status (8)

Country Link
US (1) US20180031528A1 (https=)
EP (1) EP3256846A1 (https=)
JP (1) JP2018508793A (https=)
KR (1) KR20170110716A (https=)
CN (1) CN107209155A (https=)
AU (1) AU2016218072A1 (https=)
CA (1) CA2975027A1 (https=)
WO (1) WO2016128316A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112034083A (zh) * 2020-07-30 2020-12-04 北京卫星制造厂有限公司 一种液相色谱泵流路超低死体积的标定方法及系统

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Publication number Priority date Publication date Assignee Title
RU2729116C2 (ru) 2015-12-16 2020-08-04 Гритстоун Онколоджи, Инк. Идентификация, производство и применение неоантигенов
KR20260039788A (ko) 2017-10-10 2026-03-20 시애틀 프로젝트 코포레이션 핫스팟을 이용한 신생항원 동정
CA3083097A1 (en) 2017-11-22 2019-05-31 Gritstone Oncology, Inc. Reducing junction epitope presentation for neoantigens
US20190227040A1 (en) * 2018-01-22 2019-07-25 Thermo Finnigan Llc Method and Apparatus for Chromatograph Nano-Flow Fractionator

Citations (10)

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CN1094813A (zh) * 1992-08-13 1994-11-09 惠特利公司 用于过程分析器的流体流选择器
US20040038384A1 (en) * 2000-05-23 2004-02-26 Jacques Dussauze Installation and process for automatic preparation of samples
WO2005114168A1 (en) * 2004-05-22 2005-12-01 Agilent Technologies, Inc. Combi column
CN2859526Y (zh) * 2005-07-28 2007-01-17 上海烟草（集团）公司 一种大孔径柱到毛细柱的多维气相色谱系统
WO2010072546A1 (en) * 2008-12-04 2010-07-01 Vrije Universiteit Brussel A chromatographic separation device with variable length and a method for its use
CN102918309A (zh) * 2010-05-20 2013-02-06 生物辐射实验室股份有限公司 旋转的圆柱选择阀
CN203060889U (zh) * 2012-12-19 2013-07-17 大连依利特分析仪器有限公司 液相色谱用全自动制备级馏分收集阀站
CN103582812A (zh) * 2011-06-09 2014-02-12 沃特世科技公司 减少由于在平面微流体分离装置中的过孔而引起的分散
CN103687654A (zh) * 2011-05-26 2014-03-26 赛默电子制造有限公司 用于改进的分辨率的色谱法的方法和设备
CN203935755U (zh) * 2010-09-22 2014-11-12 魄金莱默保健科学有限公司 用于色谱的反冲系统和装置

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JPH037815Y2 (https=) * 1984-10-05 1991-02-26
US6748975B2 (en) * 2001-12-26 2004-06-15 Micralyne Inc. Microfluidic valve and method of manufacturing same
US8123949B2 (en) * 2005-01-20 2012-02-28 Waters Technologies Corporation Methods for separating compounds
WO2007052223A2 (en) * 2005-11-01 2007-05-10 The Procter & Gamble Company Multi-phase personal care composition comprising a depositing perfume
EP2596134B1 (en) * 2010-07-23 2020-04-08 President and Fellows of Harvard College Methods of detecting diseases or conditions using phagocytic cells
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HUP1100312A2 (en) * 2011-06-14 2013-01-28 Emil Dr Mincsovics Procedure and equipment for improving of performance characteristics of column chromatography separation processes

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CN1094813A (zh) * 1992-08-13 1994-11-09 惠特利公司 用于过程分析器的流体流选择器
US20040038384A1 (en) * 2000-05-23 2004-02-26 Jacques Dussauze Installation and process for automatic preparation of samples
WO2005114168A1 (en) * 2004-05-22 2005-12-01 Agilent Technologies, Inc. Combi column
CN2859526Y (zh) * 2005-07-28 2007-01-17 上海烟草（集团）公司 一种大孔径柱到毛细柱的多维气相色谱系统
WO2010072546A1 (en) * 2008-12-04 2010-07-01 Vrije Universiteit Brussel A chromatographic separation device with variable length and a method for its use
CN102918309A (zh) * 2010-05-20 2013-02-06 生物辐射实验室股份有限公司 旋转的圆柱选择阀
CN203935755U (zh) * 2010-09-22 2014-11-12 魄金莱默保健科学有限公司 用于色谱的反冲系统和装置
CN103687654A (zh) * 2011-05-26 2014-03-26 赛默电子制造有限公司 用于改进的分辨率的色谱法的方法和设备
CN103582812A (zh) * 2011-06-09 2014-02-12 沃特世科技公司 减少由于在平面微流体分离装置中的过孔而引起的分散
CN203060889U (zh) * 2012-12-19 2013-07-17 大连依利特分析仪器有限公司 液相色谱用全自动制备级馏分收集阀站

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THERMO FISHER SCIENTIFIC INC: "《HPLC Analysis of Biomolecules Technical Guide》", 31 December 2010 *
TOM VAN DE GOOR ET AL: "Improving Protein Identification on a Microfluidic HPLC-MS Chip", 《ASMS 2010》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112034083A (zh) * 2020-07-30 2020-12-04 北京卫星制造厂有限公司 一种液相色谱泵流路超低死体积的标定方法及系统

Also Published As

Publication number Publication date
EP3256846A1 (en) 2017-12-20
WO2016128316A1 (en) 2016-08-18
KR20170110716A (ko) 2017-10-11
JP2018508793A (ja) 2018-03-29
CA2975027A1 (en) 2016-08-18
US20180031528A1 (en) 2018-02-01
AU2016218072A1 (en) 2017-08-24

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