KR20170090422A - 도파민 d3 수용체 길항제 화합물 - Google Patents
도파민 d3 수용체 길항제 화합물 Download PDFInfo
- Publication number
- KR20170090422A KR20170090422A KR1020177014318A KR20177014318A KR20170090422A KR 20170090422 A KR20170090422 A KR 20170090422A KR 1020177014318 A KR1020177014318 A KR 1020177014318A KR 20177014318 A KR20177014318 A KR 20177014318A KR 20170090422 A KR20170090422 A KR 20170090422A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- heptane
- phenyl
- azaspiro
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1419430.2 | 2014-10-31 | ||
| GB1419433.6 | 2014-10-31 | ||
| GBGB1419430.2A GB201419430D0 (en) | 2014-10-31 | 2014-10-31 | Dopamine D3 receptor antagonist compounds |
| GBGB1419433.6A GB201419433D0 (en) | 2014-10-31 | 2014-10-31 | Dopamine D3 receptor antagonist compounds |
| PCT/GB2015/053272 WO2016067043A1 (en) | 2014-10-31 | 2015-10-30 | Dopamine d3 receptor antagonists compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20170090422A true KR20170090422A (ko) | 2017-08-07 |
Family
ID=54427799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177014318A Withdrawn KR20170090422A (ko) | 2014-10-31 | 2015-10-30 | 도파민 d3 수용체 길항제 화합물 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10000477B2 (OSRAM) |
| EP (1) | EP3212637B1 (OSRAM) |
| JP (1) | JP2017532364A (OSRAM) |
| KR (1) | KR20170090422A (OSRAM) |
| CN (1) | CN107108597B (OSRAM) |
| AU (1) | AU2015340308B2 (OSRAM) |
| CA (1) | CA2964103C (OSRAM) |
| DK (1) | DK3212637T3 (OSRAM) |
| ES (1) | ES2883831T3 (OSRAM) |
| IL (2) | IL251725B (OSRAM) |
| MA (1) | MA40858A (OSRAM) |
| MX (1) | MX2017005484A (OSRAM) |
| NZ (1) | NZ731118A (OSRAM) |
| RU (1) | RU2017118562A (OSRAM) |
| SG (1) | SG11201702982UA (OSRAM) |
| WO (1) | WO2016067043A1 (OSRAM) |
| ZA (1) | ZA201702765B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2017005484A (es) * | 2014-10-31 | 2017-10-20 | Indivior Uk Ltd | Compuestos antagonistas del receptor de dopamina d3. |
| CN106883192B (zh) * | 2017-03-30 | 2019-05-14 | 苏州汉德创宏生化科技有限公司 | 含氮类杂环抗肿瘤药物活性物恶唑基修饰的苯甲酸类化合物的合成方法 |
| WO2019146740A1 (ja) | 2018-01-26 | 2019-08-01 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する環式化合物 |
| TWI767148B (zh) * | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| PH12022550605A1 (en) * | 2019-09-13 | 2023-09-25 | Nimbus Saturn Inc | Hpk1 antagonists and uses thereof |
| PE20221454A1 (es) | 2019-10-09 | 2022-09-21 | Novartis Ag | Derivados de 2-azaespiro[3.4]octano como agonistas de m4 |
| CN114555592B (zh) | 2019-10-09 | 2024-09-06 | 诺华股份有限公司 | 作为m4激动剂的2-氮杂螺[3.4]辛烷衍生物 |
| CN110981795B (zh) * | 2019-12-18 | 2021-02-12 | 武汉世纪久海检测技术有限公司 | 一种利用2-氰基异烟酸甲酯制备2-氨酰基异烟酸的方法 |
| WO2021127333A1 (en) * | 2019-12-19 | 2021-06-24 | Casma Therapeutics, Inc. | Trpml modulators |
| WO2022213062A1 (en) | 2021-03-29 | 2022-10-06 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
| CN116082192B (zh) * | 2021-06-11 | 2024-09-13 | 重庆医药高等专科学校 | 一种反式4-(叔丁氧羰氨基)环己烷羧酸的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3654305A (en) * | 1970-01-26 | 1972-04-04 | Robins Co Inc A H | 5-azaspiro(2.4)heptanes |
| AU658134B2 (en) | 1989-12-28 | 1995-04-06 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
| JPH06509069A (ja) | 1991-06-27 | 1994-10-13 | バージニア・コモンウェルス・ユニバーシティ | シグマレセプターリガンドおよびその用途 |
| US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| WO2001021615A1 (fr) | 1999-09-17 | 2001-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Dérivés de benzimidazole |
| EP1248770A1 (en) | 1999-12-16 | 2002-10-16 | Biostream Therapeutics | 1,3,4-substituted piperidine analogs and uses thereof in treating addictions |
| MY137020A (en) | 2000-04-27 | 2008-12-31 | Abbott Lab | Diazabicyclic central nervous system active agents |
| ES2315494T3 (es) * | 2002-04-26 | 2009-04-01 | Schering Corporation | Antagonistas muscarinicos. |
| CN101044134A (zh) | 2004-09-20 | 2007-09-26 | 塔加西普特公司 | 具有烟碱性胆碱能受体活性的氮杂螺烯和氮杂螺烷化合物 |
| GB0502509D0 (en) | 2005-02-07 | 2005-03-16 | Pfizer Ltd | Novel salt form of a dopamine agonist |
| US7977346B2 (en) | 2006-01-17 | 2011-07-12 | Guoqing Paul Chen | Spiro compounds and methods of use |
| JP2009528315A (ja) | 2006-03-01 | 2009-08-06 | ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ | シグマ受容体阻害剤としてのピラゾール誘導体 |
| TW200813051A (en) * | 2006-05-08 | 2008-03-16 | Neurogen Corp | Substituted azaspiro derivatives |
| US20080247964A1 (en) * | 2006-05-08 | 2008-10-09 | Yuelian Xu | Substituted azaspiro derivatives |
| GB0700786D0 (en) | 2007-01-15 | 2007-02-21 | Pfizer Ltd | Morpholine dopamine agonists for the treatment of pain |
| GB201004200D0 (en) | 2010-03-15 | 2010-04-28 | Univ Basel | Spirocyclic compounds and their use as therapeutic agents and diagnostic probes |
| WO2012128582A2 (en) | 2011-03-23 | 2012-09-27 | Hyundai Pharm Co., Ltd. | A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME |
| US8809552B2 (en) | 2011-11-01 | 2014-08-19 | Hoffmann-La Roche Inc. | Azetidine compounds, compositions and methods of use |
| TWI577671B (zh) | 2011-11-14 | 2017-04-11 | Sunshine Lake Pharma Co Ltd | Aminoquinazoline derivatives and salts thereof and methods of use thereof |
| ITMI20112329A1 (it) * | 2011-12-21 | 2013-06-22 | Rottapharm Spa | Nuovi derivati spiro amminici |
| MX2017005484A (es) * | 2014-10-31 | 2017-10-20 | Indivior Uk Ltd | Compuestos antagonistas del receptor de dopamina d3. |
-
2015
- 2015-10-30 MX MX2017005484A patent/MX2017005484A/es unknown
- 2015-10-30 EP EP15790229.7A patent/EP3212637B1/en active Active
- 2015-10-30 JP JP2017523340A patent/JP2017532364A/ja active Pending
- 2015-10-30 CN CN201580071094.4A patent/CN107108597B/zh active Active
- 2015-10-30 ES ES15790229T patent/ES2883831T3/es active Active
- 2015-10-30 AU AU2015340308A patent/AU2015340308B2/en active Active
- 2015-10-30 CA CA2964103A patent/CA2964103C/en active Active
- 2015-10-30 KR KR1020177014318A patent/KR20170090422A/ko not_active Withdrawn
- 2015-10-30 WO PCT/GB2015/053272 patent/WO2016067043A1/en not_active Ceased
- 2015-10-30 DK DK15790229.7T patent/DK3212637T3/da active
- 2015-10-30 SG SG11201702982UA patent/SG11201702982UA/en unknown
- 2015-10-30 NZ NZ731118A patent/NZ731118A/en unknown
- 2015-10-30 RU RU2017118562A patent/RU2017118562A/ru not_active Application Discontinuation
- 2015-10-30 MA MA040858A patent/MA40858A/fr unknown
- 2015-10-30 US US15/522,863 patent/US10000477B2/en active Active
-
2017
- 2017-04-13 IL IL251725A patent/IL251725B/en active IP Right Grant
- 2017-04-19 ZA ZA2017/02765A patent/ZA201702765B/en unknown
-
2018
- 2018-05-09 US US15/975,466 patent/US10239870B2/en active Active
-
2019
- 2019-01-29 US US16/261,206 patent/US10654842B2/en active Active
-
2020
- 2020-07-30 IL IL276400A patent/IL276400A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017532364A (ja) | 2017-11-02 |
| US20170334895A1 (en) | 2017-11-23 |
| AU2015340308B2 (en) | 2019-09-19 |
| IL251725A0 (en) | 2017-06-29 |
| US10654842B2 (en) | 2020-05-19 |
| RU2017118562A (ru) | 2018-11-30 |
| CN107108597B (zh) | 2020-04-17 |
| US20190300514A1 (en) | 2019-10-03 |
| WO2016067043A1 (en) | 2016-05-06 |
| CA2964103A1 (en) | 2016-05-06 |
| IL251725B (en) | 2020-08-31 |
| ZA201702765B (en) | 2019-05-29 |
| MX2017005484A (es) | 2017-10-20 |
| CA2964103C (en) | 2022-08-30 |
| CN107108597A (zh) | 2017-08-29 |
| NZ731118A (en) | 2023-05-26 |
| US10000477B2 (en) | 2018-06-19 |
| EP3212637A1 (en) | 2017-09-06 |
| BR112017009042A2 (pt) | 2018-07-03 |
| ES2883831T3 (es) | 2021-12-09 |
| US10239870B2 (en) | 2019-03-26 |
| AU2015340308A1 (en) | 2017-05-11 |
| EP3212637B1 (en) | 2021-06-02 |
| MA40858A (fr) | 2021-03-31 |
| DK3212637T3 (da) | 2021-07-12 |
| RU2017118562A3 (OSRAM) | 2019-05-28 |
| US20180282318A1 (en) | 2018-10-04 |
| IL276400A (en) | 2020-09-30 |
| SG11201702982UA (en) | 2017-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20170526 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination |