KR20170079340A - Swelling calves relief patch and manufacturing method of same - Google Patents

Swelling calves relief patch and manufacturing method of same Download PDF

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KR20170079340A
KR20170079340A KR1020150189788A KR20150189788A KR20170079340A KR 20170079340 A KR20170079340 A KR 20170079340A KR 1020150189788 A KR1020150189788 A KR 1020150189788A KR 20150189788 A KR20150189788 A KR 20150189788A KR 20170079340 A KR20170079340 A KR 20170079340A
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edema
hydrogel
patch
weight
extract
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KR101768709B1 (en
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김정현
신민철
문정민
김성빈
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주식회사 케이티에이치아시아
주식회사 메디셀바이오
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Abstract

The present invention relates to a skin temperature responsive functional hydrogel which is applied to a patch to help alleviate edema when the patch is attached to a calf of a patient having swelling and has no adverse effect on the skin even when the patch is attached for a long time, The present invention relates to a patch for relieving calf edema using a skin temperature-responsive functional hydrogel, which helps to alleviate long-lasting edema due to continuous dissolution of a substance,
The composition is prepared by preparing a patch for alleviating edema composed of a urethane film, a nonwoven fabric, a hydrogel, an edema-relieving agent, an auxiliary additive, and a release film, wherein the hydrogel is made of polyacrylic acid, glycerin, water, Wherein the edema-modifying agent is a mixture of a bilberry extract, a dandelion extract, a grape seed extract, and a vitamin agent, and the auxiliary additive is a root of yam root, The hydrogel, the edema-relieving agent and the auxiliary additive are mixed in a ratio of 80 to 90% by weight of the hydrogel, 8 to 14% by weight of the edema-reducing agent, 8 to 14% by weight of the auxiliary additive 2 To 6% by weight.

Description

Technical Field [0001] The present invention relates to a patch for relieving calf edema using a skin temperature responsive functional hydrogel, and a manufacturing method thereof.

The present invention relates to a hydrogel which, when adhered to the periphery of a calf, causes a chemical change in the sol state while slowly dissolving in response to a temperature around the calf to be absorbed into the skin around the calf and an effect to help relieve calf edema And a method for producing a patch for relieving calf edema using the prepared functional hydrogel.

The exact position of the calf is the extremity of the body between the knee and ankle. It is also called as the so - called tongue, and it is one of the areas where the fat is less and the muscle is more difficult to manage than the other body parts. However, nowadays, the importance of the body line, the calf is an important part of the human body that can not be left for the legs.

Unlike diets, calves are less able to reduce size compared to other parts of the body, and when exercised with excessive force or in the wrong way, they can stimulate the calf muscles to develop excessive muscles and produce so-called calf eggs.

On the other hand, such problems also occur when a person who is mainly engaged in a standing job, for example, a nurse, a hairdresser, a salesperson, a golf course assistant, a teacher, Usually, calves are divided into muscular, fatty, and edematous types. In the case of muscle type, for example, excessive exercise will cause the muscles to develop more, so avoid excessive exercise such as jogging, squash, aerobics, massage and stretching to loosen the muscles tightly tightened, good.

Edema refers to a state in which fluid in the capillary blood escapes outside the blood vessels and accumulates in the epileptic tissues, and can be divided into local edema and systemic edema depending on the distribution of the body. Diagnosis of edema itself is not so difficult. You can easily see it by pressing the front of the calf or by examining the radiation, and often you know it first. More importantly, it is necessary to identify the cause of edema and take appropriate action accordingly. Therefore, if you walk a bit or get tired a little, the type of swelling calves that immediately swollen your legs is caused by the accumulation of lactic acid, which is a substance of fatigue, and blood circulation disorder, so you should avoid excessive exercise and treatments that remove swelling with half-bath or massage . Fatty calves are a type found in many people with fat as a whole. It is necessary to exercise diet at the same time as exercise and to carry out regular exercise, aerobic exercise which burns fat and treatment which is effective for cellulite decomposition.

Korean Patent Publication No. 10-2014-0077797 (June 24, 2014). Korean Patent No. 10-1442046 (Dec. 12, 2014) Korean Patent No. 10-1453262 (Oct. 15, 2014)

The present invention relates to a functional hydrogel containing a bilberry extract, a dandelion extract, a grape seed extract, and a vitamin preparation in a hydrogel which slowly melts and is absorbed into the skin in response to calf temperature when attached to a calf of a patient having calf edema, The present invention has been made in view of the above problems.

According to an aspect of the present invention, there is provided a method of manufacturing a nonwoven fabric, comprising the steps of: applying an adhesive (15) to one surface of a urethane film (10); Preparing a functional hydrogel by mixing the hydrogel (25) with an anti-edema agent having an effect of alleviating edema of the calf and an auxiliary additive having cross-linking and moisturizing effect; The functional hydrogel is applied to the surface of the nonwoven fabric 20 or one side surface of the release film 30 and then the functional hydrogel is closely contacted with the nonwoven fabric 20 and the release film 30, ; Aging and drying the patch sheet to form the functional hydrogel in a semi-solid state functional hydrogel; Cutting a patch sheet in which the functional hydrogel is in a semi-solid state to a shape similar to a region where the human body is applied,

The hydrogel 25 is composed of polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate 60, and the edema- Wherein the supplementary additive is a mixture of one or both of the root extract of yam root and the horse root root extract and is mixed with the hydrogel (25) and the edema-reducing agent and the auxiliary The mixing ratio of the additives is 80 to 90% by weight of the hydrogel, 8 to 14% by weight of the edema-reducing agent, and 2 to 6% by weight of the auxiliary additive.

Before the urethane film 10 and the nonwoven fabric 20 are adhered to each other, a step of dyeing or silk printing the selected color to the urethane film 10 or the nonwoven fabric 20 is further added.

The hydrogel 25 may contain 38 to 59.6 wt% of polyacrylic acid, 8 to 18.4 wt% of glycerin, 0.8 to 1.2 wt% of sodium hydroxide, 0.8 to 1.2 wt% of agar, Wherein the supplementary additive comprises 30 to 40% by weight of Polysorbate 60, 30 to 40% by weight of Polysorbate 60, 30 to 40% by weight of Polysorbate 60, The dandelion extract is contained in an amount of 35 to 43% by weight, the grape seed extract is contained in an amount of 35 to 43% by weight, the vitamin preparation 0.5 To 2% by weight.

The vitamin preparation may be any one selected from the group consisting of vitamin A, vitamin B, vitamin C, vitamin E, magnesium, calcium, zinc, and selenium.

The semi-solid state of the functional hydrogel is formed by aging the mixture at 50 to 80 ° C for 2 to 4 days and then drying the aged functional hydrogel for 1 to 3 days.

The patch for relieving the calf edema using the skin temperature responsive functional hydrogel of the present invention manufactured by the above-described method, when applied to a calf of a patient having swelling, responds to the skin temperature so that the functional hydrogel is in a sol state The functional material contained in the functional hydrogel can be smoothly penetrated into the skin to alleviate edema. In particular, even when used for a long period of time, there is no adverse effect on the skin, and the sustained elution of the functional material effectively alleviates edema I will.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a process diagram showing a method for manufacturing a patch for relieving calf edema of the present invention. FIG.
2 is a sectional view for explaining a patch configuration for relieving calf edema of the present invention;

As shown in FIG. 1, the method for manufacturing patch for relieving calf edema using the skin temperature-sensitive functional hydrogel according to the present invention comprises the steps of applying an adhesive 15 to one surface of a urethane film 10 and then bonding the nonwoven fabric 20 step; Preparing a functional hydrogel by mixing the hydrogel (25) with an anti-edema agent having an effect of alleviating edema of the calf and an auxiliary additive having cross-linking and moisturizing effect; The functional hydrogel is applied to the surface of the nonwoven fabric 20 or one side surface of the release film 30 and then the functional hydrogel is closely contacted with the nonwoven fabric 20 and the release film 30, ; Aging and drying the patch sheet to form the functional hydrogel in a semi-solid state functional hydrogel; Cutting a patch sheet in which the functional hydrogel is in a semi-solid state to a shape similar to a region where the human body is applied,

The hydrogel 25 is composed of polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate 60, and the edema- Wherein the supplementary additive is a mixture of one or both of the root extract of yam root and the horse root root extract and is mixed with the hydrogel (25) and the edema-reducing agent and the auxiliary The mixing ratio of the additives is 80 to 90% by weight of the hydrogel, 8 to 14% by weight of the edema-reducing agent, and 2 to 6% by weight of the auxiliary additive.

Before the urethane film 10 and the nonwoven fabric 20 are adhered to each other, a step of dyeing or silk printing the selected color to the urethane film 10 or the nonwoven fabric 20 is further added.

The hydrogel 25 may contain 38 to 59.6 wt% of polyacrylic acid, 8 to 18.4 wt% of glycerin, 0.8 to 1.2 wt% of sodium hydroxide, 0.8 to 1.2 wt% of agar, Wherein the supplementary additive comprises 30 to 40% by weight of Polysorbate 60, 30 to 40% by weight of Polysorbate 60, 30 to 40% by weight of Polysorbate 60, The dandelion extract is contained in an amount of 35 to 43% by weight, the grape seed extract is contained in an amount of 35 to 43% by weight, the vitamin preparation 0.5 To 2% by weight.

The vitamin preparation may be any one selected from the group consisting of vitamin A, vitamin B, vitamin C, vitamin E, magnesium, calcium, zinc, and selenium.

The semi-solid state of the functional hydrogel is formed by aging the mixture at 50 to 80 ° C for 2 to 4 days and then drying the aged functional hydrogel for 1 to 3 days.

Hereinafter, functional materials used for preparing patches for calf edema mitigation using the skin temperature responsive functional hydrogel of the present invention will be described as follows.

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1) Bilberry was first approved as a medicinal product in 1976, then it was commercialized as a medicinal product in Europe. Bilberry extract was proved to be effective as a medicinal product. Bilberry leaf extract has excellent whitening effect and antioxidant activity and is used as a cosmetic raw material . Bilberries contain a large amount of anthocyanin. Anthocyanins help protect the eyes and relieve eye fatigue, help the blood circulation of the capillaries of the retina, and help weakened eyesight and night blindness. In addition, anthocyanins have antioxidant properties that help lower blood pressure and maintain normal levels, thereby increasing insulin production. Therefore, it is a very useful ingredient for patients suffering from diabetes.

In addition, anthocyanin components also help the liver, stomach, and kidney function. Another of the benefits of bilberry is the ability to remove platelets that block blood vessels. This not only helps blood circulation, but also helps prevent microvascular destruction due to the Flavonoid component.

Bilberry contains antioxidant quercetin and resveratrol ingredients, which inhibit free radicals and provide nutrients to rough skin due to vitamin C, vitamin B and vitamin C. In addition, bilberry helps prevent cell senescence If the possibility of cell mutation is lowered and taken steadily, the incidence of cancer cells can be lowered.

In addition to this, bilberry is also effective in preventing menses, laryngitis, cholelithiasis, hematogenesis, insomnia, chronic fatigue, cologenesis, cough, diarrhea, indigestion, inflammation, cataracts, glaucoma, gout, hemorrhoids, hypertension, , Prevention and treatment of rheumatism, gastric ulcer, and edema.

2) Dandelion largely has four effects. First, Silymarin contained in dandelion makes hepatocyte good and detoxifies liver and improves liver function. Second, taking dandelion makes the intestines strong and helps to treat and prevent constipation. Third, it helps to remove edema of a person who usually swims well. If you drink dandelion roots or leaves dalyeoseo three times a day on an empty stomach is good for eliminating edema. In addition, because of its excellent antipyretic action, it is very good for heat due to a cold, respiratory diseases such as cough treatment and asthma. Finally, dandelion, which has the effect of treating inflammation, also helps in the treatment of various gastrointestinal diseases.

3) Grape seed is Vitis vinifera Ext. In other words, the grape extract contains a large amount of various physiologically active substances (flavonoid, polyphenol, anthocyanin, etc.) and has effects such as antioxidative action, anti-inflammatory action, antibacterial action, and protects against cardiovascular, liver, nervous system, It is effective.

4) Yams are also called sugar beans and grow mainly in mountain areas. The stem comes out from the flesh root of the circumference type and hoists up another object. Leaves are opposite or staggered, petiole is long, long oval or triangular, pointed end, bottom is heart-bottomed, hairless.

The main shoots grow on the axilla. The flower is a single flower, blooming in June to July, and runs on a water inflorescence. The male flower ears stand upright, the female flower ears fall down, and white flowers hang. Male flowers have 6 stamens, foliage pieces and 1 pistil, and female flower has 6 filigree pieces and 1 pistil. The fruit is capsule with three wings and the seed also has membranous wings. In particular, the root of yam is root, which means that the root of the yam has grown in size due to the accumulation of nutrients, and the yam root is rich in phyto-mucin (similar to the component of snail mucus as a vegetative mucin) It is included to prevent the skin from drying out, protect the skin from the outside and exert the effect of healing wounds.

5) Horseback riding is also known as an abattoir, growing in deep mountain forests and about 1m in height. It has a thick roots and purplish black. Leaves are alternate phyllotaxis, long petiole, and divide 3 ~ 1 ~ 2 times. Small leaves are ovate, often split into 2-3, with irregular sawtooth. The flowers bloom in August to September in white, with a large conical flower on top of the stem. Calyx is 4 ~ 5 pieces, petals are 2 ~ 3 pieces, and ends are usually divided into 2 pieces. There are many surgeries and ovaries. The fruit is ripened in October as molten and ossified fruit. Breeding is done by seeding, abandoning or leaking. The main efficacy of horse riding can be seen as 升 (up) and mountain (). The word "wins" refers to the symptoms that occur when the stomach does not climb up, such as symptoms of gastrointestinal tract, intestinal wastewater, dehydration, tachypnea, and headache, literally lifting up the stamen. It means to distract the heat poison which is staying in the inside. Therefore, when riding is used as a topical agent for skin, the effect is judged on the basis of these properties. The concept of w is given from the viewpoint of giving elasticity to wrinkled skin and improving wrinkles. The concept of acid is dermatitis due to heat, It can be considered from the viewpoint of releasing the fungus that causes the trouble, and the effects such as antioxidation, anti-aging, moisturizing, sedation can be seen.

The listed functional ingredients exhibit excellent effects on alleviation of edema, skin moisturization, etc. Specifically, the blood circulation is smoothly facilitated, thereby alleviating edema and reducing various kinds of pain.

In the present invention, it is preferable to extract the active ingredient by a hot water extraction method having a wide extraction range, and the hot water extraction method is a method of extracting an active ingredient from the above- As already well known, this means an extraction method in which each of the obtained raw materials is washed, the washed raw material is supplied to a heating vessel together with water, and then the mixture is heated to a strong fire to be lowered to a low temperature and then quenched Since this is a conventional extraction method, a detailed description is omitted.

Hereinafter, a method for manufacturing a patch for relieving calf edema using the skin temperature responsive functional hydrogel of the present invention will be described in detail as follows.

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a) bonding the nonwoven fabric to one side of the urethane film

The step (a) of the present invention is a step of applying the adhesive 15 to one surface of the urethane film 10 and then bonding the nonwoven fabric 20 as shown in Fig. 2. The reason for using the urethane film 10 is that, And it is easy to deform in accordance with the bending shape of the skin and moisture evaporation can be suppressed.

The reason why the nonwoven fabric 20 is used is that it maintains a close contact force with the skin, is safe to the skin to be contacted, sufficiently functions the skin temperature responsive hydrogel of the present invention, At the same time, long-term storage is possible.

In order to colorize the calf swelling mitigation patch of the present invention, the urethane film 10 or the nonwoven fabric 20 is dyed or silk printed in a selected color before the urethane film 10 and the nonwoven fabric 20 are bonded to each other It is possible. The silk printing is one of various printing techniques in which a film is formed and then a dye is poured and pushed out with a rubber so as to stain the dye.

A mark such as a specific logo, a character, or a trademark may be printed on the urethane film 10 or the nonwoven fabric 20, or may be embossed or embossed so as to have a curved surface in addition to a printing method.

When the nonwoven fabric 20 is adhered to one surface of the urethane film 10, the adhesive 15 is applied to one surface of the urethane film 10 and then the nonwoven fabric 20 is adhered to the surface of the urethane film 10 and laminating To the surface of the substrate).

b) preparing a skin temperature responsive functional hydrogel

Step (b) of the present invention is a step of producing a functional hydrogel having an edema-relieving effect, which is a main feature of the present invention and will be described separately below.

c) Patch Sheet Production Step

In step c) of the present invention, after the functional hydrogel prepared in step b) is applied to the surface of the nonwoven fabric 20 or one side of the release film 30, the functional hydrogel is separated from the nonwoven fabric 20 and the release film The nonwoven fabric 20 and the release film 30 are adhered to each other by a rolling device so that the nonwoven fabric 20 having the functional hydrogel coated thereon and the release film 30 are closely contacted with each other, 30) can be mixed.

d) Formation of semi-solid state of functional hydrogel in patch sheet

In the step d) of the present invention, the functional hydrogel contains a functional material composed of a mixture of components in the form of a liquid phase, and the functional hydrogel has a molecular structure in the sol state, When the functional hydrogel is applied, most of the functional hydrogel is separated from the nonwoven fabric 20 and the functional hydrogel is applied to the hand in the process of using the product by the user,

The patch sheet is aged and then dried to form the functional hydrogel as a semi-solid functional hydrogel. One example of forming the functional hydrogel in a semi-solid state is to aged at 50 to 80 ° C for 2 to 4 days, and then aging the functional hydrogel to dry at room temperature in a closed space for 1 to 3 days. The aging period is most preferably 2 days to 4 days, and if it exceeds 4 days, it is gradually cured so that it does not exceed 4 days. If the drying time is less than 1 day, the viscosity is too much to use on the skin, and if it is more than 3 days, the viscosity becomes too small and it is easily disadvantageous when it is used.

The functional hydrogels existing between the nonwoven fabric 20 and the release film 30 are formed in the semi-solid state functional hydrogels through the above-described process because they are close to a sol state so that they do not flow out to the outside during distribution or storage .

The reason why the functional hydrogel is aged at 50 to 80 ° C for 2 to 4 days is that the polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate A plant extract enzyme in which a bilberry extract, a dandelion extract, a grape seed extract, a yam root extract and a horse root root extract are mixed with a hydrogel (25) composed of a polysorbate 60 (Polysorbate 60) So that it is aged and stabilized.

As described above, the patch including the functional hydrogel formed in a semi-solid state dissolves the gel-like hydrogel 25 in response to the body temperature, i.e., the skin temperature due to the application mechanism of sodium hydroxide upon adhering to the skin, State, thereby eventually transferring the functional substance to the skin.

Therefore, the functional hydrogels containing sodium hydroxide are sensitive to skin temperature, so that components that function to relieve calf edema are easily transferred to the affected part.

e) Patch sheet cutting step

Step e) of the present invention is a step of cutting the patch sheet in which the functional hydrogel is in a semi-solid state into a shape similar to the application site of the human body, which is cut so that it can be applied to the entire user's calf or a part of the user's calf.

The method of manufacturing the skin temperature responsive hydrogel of step b), and the action and effect of the skin temperature responsive hydrogel of the present invention described above, in the method of manufacturing a patch for relieving calf edema using the skin temperature responsive hydrogel of the present invention will be described as follows.

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The functional hydrogel of the present invention comprises 80 to 90% by weight of a hydrogel, 8 to 14% by weight of an edema-reducing agent and 2 to 6% by weight of an auxiliary additive,

The hydrogel 25 is composed of polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate 60, and the edema- A dandelion extract, a grape seed extract, and a vitamin agent. The auxiliary additive is a mixture of one or both of a root extract of yam root and an extract of horse root root.

Polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate 60, which constitute the hydrogel 25, are commonly used in the manufacture of patches, A specific description thereof is omitted. The composition of the embodiment is 38 to 59.6% by weight of polyacrylic acid, 8 to 18.4% by weight of glycerin, 0.8 to 1.2% by weight of sodium hydroxide, 0.8 to 1.2% by weight of Agar, 0.8 to 1.2% by weight of Polysorbate 60 and 30 to 40% by weight of water.

Polyacrylic acid among the components of the hydrogel (25) is preferably used as a polymer polymer in an amount of 38 to 59.6% by weight.

On the other hand, the polyacrylic acid is preferably used alone, but polyacrylic acid, polymethacrylic acid, polyacrylic acid copolymer, and polymethacrylic acid copolymer may be used alone or in combination. When the polyacrylic acid is used in an amount of less than 38% by weight, it is difficult to maintain the patch shape and adherence is deteriorated. When the polyacrylic acid is used in an amount exceeding 59.6% by weight, the release rate of the hydrogel Is lowered.

Glycerin may exert the function of a moisturizing softener, but acts as a patch for alleviating calf edema by imparting viscosity to improve spreadability (spreadability). The preferable content of the glycerin is 8 to 18.4 wt%.

Sodium hydroxide is an application mechanism for dissolving the gelated hydrogel 25 into a fluidized state. The preferable content of the sodium hydroxide is 0.8 to 1.2% by weight.

Agar is a viscous, complex polysaccharide mixture extracted by physical and chemical treatments with seaweed and the like as a main raw material, and has an effect of cleansing the blood of a cold person and normalizing the hormone secretion. 0.8 to 1.2% by weight.

In addition, polysorbate (Polysorbate 60) is preferably used as a surfactant (mixture of substances having different properties), and it is preferably used in an amount of 0.8 to 1.2% by weight.

Meanwhile, as described above, the edema-relieving agent contains 12 to 29.5% by weight of a bilberry extract, 35 to 43% by weight of a dandelion extract, 35 to 43% by weight of a grape seed extract, 0.5 to 2% by weight of a vitamin preparation, The extract, the horse root root extract, or both are mixed.

In the edema-relieving preparation, the reason for mixing any one or both of the bilberry extract, dandelion extract, grape seed extract, yam root extract and horse rid extract is that the effect described in 4) and 5) And the effect of protecting the skin from the outside and healing wounds, etc., in the patch for relieving edema of the present invention. In addition, yam root extract and horse root root extract contain a large amount of glycosides such as yogogenin, creptogen, and diosgenin, which act to activate hydrolysis.

The mixing ratio of the hydrogel (25), the edema-relieving agent and the auxiliary additive is 80 to 90% by weight of the hydrogel, 8 to 14% by weight of the edema-reducing agent and 2 to 6% by weight of the auxiliary additive, 5), the efficacy such as alleviation of edema differs depending on the functional raw material, so that the different effects are applied to the patch of the present invention. Here, mixing the auxiliary additive in the functional hydrogel of the present invention is intended to increase softness and moisturization of the skin even after patch removal due to the above-mentioned effects.

On the other hand, if the edema-modifying agent is used in an amount of less than 8% by weight based on the total weight of the functional hydrogel patch composition, the edema-mitigating effect is insufficient, and if it is used in an amount exceeding 14% by weight, edema- It may be deteriorated in performance. Therefore, it is preferable to use it within the above-mentioned range, that is, within the range of 8 to 14% by weight.

If the auxiliary additive is used in an amount less than 2% by weight based on the total weight of the functional hydrogel patch composition, the effect is not expected to be expected. If the auxiliary additive is used in an amount exceeding 6% by weight, .

When the yam root root extract and the horse root root extract are all mixed, it is preferable that the yam root root extract and the horse root root extract are mixed at a ratio of 30 to 70:30 to 70% by weight.

Hereinafter, the efficacy of the vitamin formulation contained in the edema-reducing preparation will be described.

- next -

1) Vitamin A, also called retinol, is present only in animals in the natural state. Egg yolk, liver, milk is a lot, and the carotene in the plant is changed to vitamin A in the body. Carrots are abundant in cabbage, carrots and lettuce. People who lack Vitamin A may have dry eye syndrome. Vitamin A is a component of two pigments that make the eye normal when light intensity is different.

2) Vitamin B is an indispensable vitamins of animals found in 1911 by casimir funk and Suzuki 梅 太郎. There are many kinds of vitamins. B 1 , B 2 , B 3 , B 4 , B 5 , B 6 , B 12 , nicotinic acid, folic acid (folic acid), and the like. They have anti-diabetic factors, anti-neurotrophic factors, growth-promoting factors, anti-dermatitis factors, and anti-pilase factors, and when they are deficient, . It is contained in rice gruel, bean, peanut, egg yolk, yeast, animal liver, spinach. It is easy to dissolve in water and alkali, stable to acid but unstable to alkali.

3) Vitamin C is a water-soluble vitamin, which is well tolerated at low temperatures. Vitamin C contained in green tea is reduced by about 90%, antioxidant vitamins with excellent physiological functions such as delayed aging and stress tolerance, scarcity, decay of resistance to scurvy, anemia, infectious diseases and melanin pigmentation, Depending on the type, green tea contains 250 ~ 300mg%, which maintains the unique function of intercellular cement material. Unstable in air and heat, unstable in alkaline solution. It is easy to break down during cooking and soluble in water, so it is easy to dissolve in water.

4) Vitamin E is tocopherol. It is yellow oil and does not dissolve in water. It is soluble in oil and organic solvent (organic solvent) and has strong anti-oxidative action. It was discovered in 1922 by Evans and others as vitamins necessary for animal reproduction. In humans, reproductive disorders caused by vitamin E deficiency are rarely found. It protects vitamin A and linoleic acid from being destroyed by oxidation in the body. As the consumption of linoleic acid increases, the demand for vitamin E also increases.

5) Magnesium Magnesium is a component of chlorophyll, so it is abundant in green leaves and is rich in nuts, pulses and cereals. However, magnesium in cereals is lost by 80 to 96% during the ripening process. Thus, magnesium is not often deficient in everyday meals, but magnesium intake may be lower if it is highly dependent on refined foods or processed foods. In addition to these, extracts of these foods, processed foods containing the following synthetic ingredients, and magnesium supplement foods are also good source foods.

6) Calcium accounts for about 2% of body weight, most of which form calcium and calcium in the form of bone and teeth. It is also present in plasma and is necessary for the regulation of muscular and nerve function and blood coagulation. The parathyroid gland hormone has the function of keeping the calcium concentration in the plasma normal. When the parathyroid gland is removed, the calcium content in the plasma is lowered, causing a special seizure called Tetany to die. The absorption rate of calcium in the intestines varies by various conditions, but is generally about one-third. When the intestinal tract is tilted to acid, absorption is improved, and vitamin B helps absorption. Milk is a good source of supply. The physiological action of parathyroid hormone was named after the Latin calx, which means lime, which promotes bone resorption of Ca ++ . The elemental metal was first obtained in 1808 by H. Davy of England, which melted and electrolyzed calcium chloride. It is highly reactive and does not exist in the natural state in the free state, but it is widely distributed on the earth as a compound. It is mainly contained in bones, teeth, etc., and is also involved in physiological action. A person's daily intake of about 0.8g is enough. Vitamin D is known to help absorption of calcium.

7) The best sources of zinc are oysters, and meat, poultry, shellfish, eggs, and dairy products are good sources of zinc given their intake and availability. The good sources of zinc in vegetable foods are peanuts, soybeans, grains and their products. Zinc in the grains is mainly present in the shell and is lost during the fermentation. Fruits and vegetables contain a small amount of zinc, and water contains little zinc. In addition, zinc is widely distributed in various oriental vegetable foods, but there are many differences in the contents depending on the foods. In general, zinc contained in animal foods is more absorbed than zinc in plant foods. In addition, extracts of these foods or processed foods containing the following synthetic ingredients and zinc supplement foods are also good source foods.

8) Selenium functions as an enzyme containing selenium in the body. Typical selenium-containing enzymes include glutathione peroxidase, thioredoxin, selenium protein P, and iodothyronine deiodinase. Glutathione peroxidase and thioredoxin are responsible for the antioxidant function of decomposing hydrogen peroxide produced by the body to inhibit cell damage caused by hydrogen peroxide. In this respect, selenium functions as an antioxidant nutrient. Selenium protein P is not yet known for its function but seems to have antioxidant properties. Inadequate selenium intake reduces selenium protein P activity to about 10% of normal.

The above vitamin preparations commonly contain ingredients that help alleviate edema. By mixing them with the edema-relieving agent, the effects to be achieved in the present invention can be further enhanced.

Hereinafter, the present invention will be described more specifically by way of Examples and Experimental Examples.

However, the scope of the present invention is not limited by the examples and experimental examples described below.

( Example ) Functional Hydro  Preparation of gel patches

After applying the adhesive to one side of the urethane film, the nonwoven fabric was bonded and mixed with bilberry extract, dandelion extract, grape seed extract, vitamin B and yam root extract in polyacrylic acid, glycerin, water, sodium hydroxide, agar and polysorbate 60 The functional hydrogel is applied to the surface of the nonwoven fabric and then the functional hydrogel is brought into close contact with the nonwoven fabric and the release film so as to be in close contact with each other to prepare a patch sheet. The functional hydrogel is heated to a temperature of 60 ° C After aging for 3 days, the hydrolyzed functional hydrogel was dried for 2 days and cut into 18 cm length and 10 cm length to prepare a functional hydrogel patch for cramping. The contents of the above components are shown in Table 1 below.

(compare Example ) Normal Hydro  Preparation of gel patches

As a control group of the functional hydrogel patch of the present invention, hydrogel patches were prepared in the same manner as in Example, except for components of berry extract, dandelion extract, grape seed extract and vitamin B were excluded. However, the contents of polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate 60, and yam root extract were the same as in the examples. The contents of the above components are shown in Table 2 below.

Ingredients content
(Unit: g) Polyacrylic acid
(Polyacrylic acid) 40 glycerin
(Glycerin) 10 Sodium hydroxide
(Sodium hydroxide) 1.4 Baby
(Agar) 1.2 Polysorbate 60
(Polysorbate 60) 1.2 water 30 Bilberry extract 18 Dandelion extract 38 Grape seed extract 40 Vitamin B One Yam root root extract 5

Ingredients content
(Unit: g) Polyacrylic acid
(Polyacrylic acid) 40 glycerin
(Glycerin) 10 Sodium hydroxide
(Sodium hydroxide) 1.4 Baby
(Agar) 1.2 Polysorbate 60
(Polysorbate 60) 1.2 water 30 Bilberry extract - Dandelion extract - Grape seed extract - Vitamin B - Yam root root extract 5

( Experimental Example ) Measurement of edema mitigation

The subjects were nurses who had experienced edema among the general nurses standing all day in the ward, and 12 persons were allocated to the embodiment of the present invention and 6 persons were allocated to the comparative embodiment. Subjects who had signs of edema were allowed to attach the patches prepared in Examples and Comparative Examples of the present invention to the calf within once-a-day working hours. During the lab, other treatments and massage were prohibited. To measure the perceived subjective edema degree, ankle and calf circumferences were measured before and after 24 hours using glass fiber tape (MK-311 Esrone tape measure 1.5 m, Vespa). The measured values are shown on the right and left averages, and the results are shown in Tables 3 and 4 below. In a comparative example, hydrogels excluded from the edema-relieving agent were attached to the calf. In the examples, a functional hydrogel containing the edema-relieving agent was attached to the calf.

experimenter Before use after use Ankle circumference
















Comparative Example




One 22.14 22.31 2 21.96 22.47 3 22.18 22.63 4 21.96 22.37 5 21.99 22.58 6 22.07 22.63 Example










One 21.60 21.27 2 21.50 20.93 3 21.56 20.87 4 22.10 21.47 5 22.07 21.61 6 22.05 21.23 7 21.58 21.00 8 21.45 21.03 9 21.63 20.77 10 22.00 21.35 11 22.17 21.45 12 22.23 21.47

experimenter Before use after use Calf circumference
















Comparative Example




One 33.39 34.51 2 33.46 33.85 3 33.51 33.90 4 32.93 34.03 5 33.79 34.71 6 33.71 34.20 Example










One 32.60 32.33 2 32.69 32.25 3 33.30 32.60 4 33.34 32.91 5 33.60 32.92 6 33.29 32.67 7 32.58 32.27 8 32.61 32.16 9 33.25 32.47 10 33.38 33.01 11 33.51 33.02 12 33.53 32.71

As a result of the above test results, the ankle perimeter and calf circumferences of the functional hydrogel patches of the present invention and general hydrogel patches (containing no edema-reducing agent) over time were measured. As a result, the functional hydrogel patches of the present invention It was found that the relaxation effect was better than the hydrogel patch.

Among other things, by developing a patch for alleviating edema using the functional hydrogel of the present invention, which lasts longer than the conventional medicines or patches, and is only required to be easily attached to the medicines during sleep or before going to bed, a high moisture content, a biocompatibility, It can be concluded that the effectiveness of the raw materials having the effect of alleviating edema in the activity can be doubled, so that an effective edema reduction effect can be expected.

While the present invention has been described in connection with certain exemplary embodiments and experimental examples, it is to be understood that the invention is not limited thereto and that various changes and modifications will be apparent to those skilled in the art. It will be understood that various modifications and changes may be made without departing from the scope of the appended claims.

10: urethane film 25: hydrogel
15: Adhesive 30: Release film
20: Nonwoven

Claims (8)

Applying an adhesive (15) to one side of the urethane film (10) and then bonding the nonwoven fabric (20);
Preparing a functional hydrogel by mixing the hydrogel (25) with an anti-edema agent having an effect of alleviating edema of the calf and an auxiliary additive having cross-linking and moisturizing effect;
The functional hydrogel is applied to the surface of the nonwoven fabric 20 or one side surface of the release film 30 and then the functional hydrogel is closely contacted with the nonwoven fabric 20 and the release film 30, ;
Aging and drying the patch sheet to form the functional hydrogel in a semi-solid state functional hydrogel;
Cutting a patch sheet in which the functional hydrogel is in a semi-solid state to a shape similar to a region where the human body is applied,
The hydrogel 25 is composed of polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate 60,
The edema-relieving agent is a mixture of a bilberry extract, a dandelion extract, a grape seed extract, and a vitamin agent,
The auxiliary additive is a mixture of any one or both of yam root extract and horse root root extract,
Wherein the mixing ratio of the hydrogel (25), the edema-relieving agent and the auxiliary additive is 80 to 90% by weight of a hydrogel, 8 to 14% by weight of an edema-reducing agent and 2 to 6% by weight of an auxiliary additive. A method for manufacturing a patch for alleviating edema. The method according to claim 1,
Characterized in that dyeing or silk printing of the selected color is further added to the urethane film (10) or the nonwoven fabric (20) before the adhesion between the urethane film (10) and the nonwoven fabric (20) ≪ / RTI > The method according to claim 1,
The hydrogel 25 may include 38 to 59.6 wt% of polyacrylic acid, 8 to 18.4 wt% of glycerin, 0.8 to 1.2 wt% of sodium hydroxide, 0.8 to 1.2 wt% of agar, 0.8 to 1.2% by weight of Polysorbate 60, and 30 to 40% by weight of water. The method for manufacturing a patch for relieving calf edema using a hydrogel according to claim 1, The method according to claim 1,
Wherein the auxiliary additive is a mixture of 30 to 70% by weight of the root extract of yam root and 30 to 70% by weight of the horse root root extract when the root extract of yam root is mixed with the horse root root extract. A method for manufacturing a patch for alleviating edema. The method according to claim 1,
Wherein the edema-relieving agent is a mixture of 12 to 29.5 wt% of a bilberry extract, 35 to 43 wt% of a dandelion extract, 35 to 43 wt% of a grape seed extract, and 0.5 to 2 wt% of a vitamin preparation. A method for manufacturing a patch for alleviating edema. 6. The method according to any one of claims 1 to 5,
Wherein the vitamin preparation is any one selected from the group consisting of vitamin A, vitamin B, vitamin C, vitamin E, magnesium, calcium, zinc, and selenium. The method according to claim 1,
The semi-solid state of the functional hydrogel is aged at 50 to 80 ° C for 2 to 4 days and then the aged functional hydrogel is dried for 1 to 3 days to prepare a patch for relieving calf edema using hydrogel . A patch for relieving calf edema using a hydrogel produced by the method of any one of claims 1 to 7.
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KR101987099B1 (en) * 2018-12-19 2019-06-10 주식회사 메디셀 Forearm patch manufacturing method the same using skin temperature-sensitized hydrogel
KR101987101B1 (en) 2018-12-19 2019-06-10 주식회사 메디셀 Calves patch and manufacturing method the same using skin temperature-sensitized hydrogel

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KR100506543B1 (en) 2003-08-14 2005-08-05 주식회사 제닉 Temperature Sensitive State-Changing Hydrogel Composition and Method for their Preparation
KR101563325B1 (en) 2015-02-27 2015-10-27 주식회사 케이티에이치아시아 Manufacturing method of alleviate fever patch thereof
KR101563324B1 (en) 2015-02-27 2015-10-27 주식회사 케이티에이치아시아 manufacturing method of eye patch thereof

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Publication number Priority date Publication date Assignee Title
KR101987099B1 (en) * 2018-12-19 2019-06-10 주식회사 메디셀 Forearm patch manufacturing method the same using skin temperature-sensitized hydrogel
KR101987101B1 (en) 2018-12-19 2019-06-10 주식회사 메디셀 Calves patch and manufacturing method the same using skin temperature-sensitized hydrogel

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