JP2012067082A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral composition effectively preventive or ameliorative of wrinkles, flabbiness or the like.SOLUTION: This oral composition contains [A] camellia seed extract and [B] N-acetylglucosamine, wherein a blending amount of [B] N-acetylglucosamine to 100 pts.mass [A] camellia seed extract is ≥50 pts.mass and ≤100 pts.mass. The oral composition preferably contains one, or two or more kinds selected from a group comprising collagen, soybean peptide and astaxanthin. Preferably, the oral composition is a drug, a quasi drug or food.

Description

  The present invention relates to oral compositions.

  Wrinkles and sagging that occur in the skin due to aging are a major concern for women, and many cosmetics and foods related to beautiful skin are on the market. Skin wrinkles and sagging are mainly caused by degeneration and destruction of collagen, elastin, and the like in the dermis due to drying, ultraviolet rays, active oxygen, and aging. The skin is composed of the stratum corneum, epidermis layer, basement membrane and dermis from the outside, and the dermis is the widest part of the skin. The dermis is configured by filling mucopolysaccharides such as hyaluronic acid in the gaps in the network structure composed of collagen and elastin.

  In particular, wrinkles and sagging increase with aging, and the cause of loss of skin gloss and firmness includes a decrease in collagen and hyaluronic acid contained in the dermis. This is because the degradation amount of collagen and hyaluronic acid exceeds the synthesis amount with aging. Conventionally, as a method of relieving wrinkles and sagging, a method of orally ingesting a food containing collagen or a method of injecting collagen directly into the skin has been adopted, but collagen is digested and decomposed in the body even if ingested orally. Therefore, collagen that does not reach the dermis in the form of collagen, and collagen that is directly injected into the skin disappears quickly from the skin, so neither can effectively improve wrinkles and sagging.

  This collagen is produced by fibroblasts in the dermis. For this reason, in recent years, active search for components that promote the growth of fibroblasts in the dermis has been actively conducted as an effective component for eliminating wrinkles and sagging. As such components, many plant components such as chlorella water extract, aloe vera extract, prickly pear extract, kyonin extract, passion flower extract and the like have been reported.

  In such a situation, a fibroblast growth promoter containing an extract obtained from the seeds of camellia japonica belonging to the genus Camellia japonica as an active ingredient has been proposed (for example, JP 2008-137998 A). There is a need for an oral composition that is more excellent in skin beautifying effects and that can simultaneously provide effects other than skin beautifying effects.

JP 2008-137998 A

  The present invention has been made in view of these circumstances, and activates fibroblasts to have a high skin beautifying effect, that is, prevention or improvement of wrinkles and sagging, and prevention or improvement of swelling, joint pain, and fatigued eyes. The purpose of the present invention is to provide an oral composition that can provide effects and the like.

  The inventors of the present invention have intensively studied to solve the above problems. As a result, when a composition comprising a camellia seed extract belonging to the camellia family camellia genus and N-acetylglucosamine is orally ingested, fibroblasts in the dermis are obtained. Is activated and the production of collagen and hyaluronic acid is promoted, so that not only the prevention or improvement effect of wrinkles and sagging is obtained, but also the prevention or improvement effect of swelling, joint pain, fatigued eyes, hair elongation, etc. The inventors found that a promoting effect can be obtained and completed the present invention.

  That is, the invention made in order to solve the said subject contains [A] camellia seed extract and [B] N-acetylglucosamine, and [B] N-acetylglucosamine with respect to 100 mass parts of [A] camellia seed extract. Is an oral composition whose blending amount is 50 parts by mass or more and 100 parts by mass or less.

  The oral composition is orally ingested by blending [B] N-acetylglucosamine in a specific ratio of 50 parts by mass or more and 100 parts by mass or less with respect to 100 parts by mass of [A] camellia seed extract. In that case, the production of collagen and hyaluronic acid can be promoted by dramatically activating the fibroblasts contained in the dermis, and wrinkles and sagging can be effectively prevented or improved. In addition, swelling, joint pain, fatigued eyes can be prevented or improved, and hair elongation can be promoted.

  The oral composition may contain one or more selected from the group consisting of collagen, soybean peptide and astaxanthin in addition to the above components. All of these ingredients have the effect of promoting beautifying skin such as moisturizing action, antioxidant action, blood circulation promoting action, etc., so by ingesting together with the above ingredients, not only wrinkles and sagging, but also skin roughness, dullness, It can prevent or control buckwheat and breakouts, and can improve the texture of makeup by aligning skin texture. Moreover, the effect of preventing or improving swelling, joint pain, fatigued eyes, and the effect of promoting hair elongation can be further improved.

  The oral composition may be a pharmaceutical, a quasi drug, or a food. The oral composition contains the above-described various components, and since any component can be taken orally, the use as a pharmaceutical, a quasi-drug, or a food is preferable. In particular, the use as a food such as supplements and drinks is more preferable because it can be easily incorporated in daily life.

  As described above, the oral composition contains [A] camellia seed extract and [B] N-acetylglucosamine, thereby effectively preventing or improving wrinkles, sagging, etc., and has an excellent skin effect. In addition, it has the effect of preventing or improving swelling, joint pain, fatigued eyes, and promoting hair elongation. In addition, the oral composition is added to foods such as supplements and drinks, or continuously taken orally as pharmaceuticals or quasi drugs, thereby promoting the synthesis of collagen and hyaluronic acid in the dermis, Can maintain and moisturize, effectively prevent and suppress not only wrinkles and sagging, but also spots, rashes, dry skin, and sunburn skin, and also has the effect of preventing or improving swelling, joint pain, fatigued eyes, etc. be able to.

  The oral composition contains [A] camellia seed extract and [B] N-acetylglucosamine as essential components, and one or more selected from the group consisting of collagen, soybean peptide and astaxanthin as optional components Containing.

<[A] Camellia seed extract>
Camellia seed extract is an extract obtained from camellia seeds belonging to Camellia japonica. Examples of such camellia include C. japonica var. Japonica, C. japonica subsp. Rusticana, and C. japonica.
var. macrocarpa), C. japonica subsp. hozanensis, C. hongkongenesis, C. reticulata, C. sallenensis, p. Examples include Yunnan species (C. pitardii var. Yunnanica), Golden flower tea (C. nitidisima), Japanese camellia (same kind of Japanese camellia), Japanese green tea flower (same kind as Japanese camellia), Japanese yam camellia (same kind as apple camellia), and the like.

  Camellia seed extract is an aqueous component obtained by pulverizing and compressing seeds obtained from the above camellia and then purifying them by a known method, and mainly includes saponins, tannins, kaempferol, and their glycosides. As a method for producing a camellia seed extract, for example, after pulverizing and compressing camellia seeds, an oily component is extracted and removed using a hydrophobic organic solvent such as hexane or heptane or a liquefied gas such as liquefied carbon dioxide or liquefied propane. The method of extracting from the defatted lees which are residues using a well-known aqueous solvent is mentioned. Specifically, a method of extracting the defatted rice cake with water and / or lower alcohol is preferable, and for example, methanol, ethanol, normal propanol, isopropanol, normal butanol, isobutanol, etc. so as not to mix oily components. It is more preferable to use a lower alcohol and / or water having a small carbon number. When using a lower alcohol having a large carbon number, it is preferable to increase the water content in order to suppress the extraction of oily components in the defatted lees. For example, when using propanol, the water content is 20% by weight or more and 50% by weight. When using butanol, the water content is preferably about 40% by weight to 70% by weight. For extraction of the aqueous component from the defatted lees, the aqueous solvent is added in an amount of about 1 to 30 times by weight with respect to 1 part by weight of the defatted lees, and normal temperature to about 120 at a pressure of 1 to 5 atm. What is necessary is just to extract, stirring as needed in the range of about 10 minutes to about 3 hours. The extract may be cooled to room temperature and filtered, and the filtrate may be concentrated and dried by an appropriate means such as drying under reduced pressure, spray drying, or freeze drying. The dried product may be appropriately pulverized or subjected to a purification process.

  As an upper limit of the content of the camellia seed extract in the oral composition, for example, 250 mg per soft capsule is preferable, 150 mg is more preferable, and 100 mg is still more preferable. On the other hand, as a minimum of the above-mentioned content of camellia seed extract, 1 mg is preferred, for example, 5 mg is more preferred, and 10 mg is still more preferred. By setting the content of the camellia seed extract in the oral composition within the above range, it is possible to effectively obtain the fibroblast activation action of the camellia seed extract, and thus the collagen production promoting action and hyaluronic acid production promoting action, etc. it can.

<[B] N-acetylglucosamine>
N-acetylglucosamine is a monosaccharide derived from glucose, and is a component that is metabolized in the body and becomes a raw material of hyaluronic acid. N-acetylglucosamine is a synthetic product obtained by acetylating D-glucosamine hydrochloride by chemical synthesis, a natural product-derived degradation product obtained by hydrolyzing chitin such as fermentation products, crabs, shrimps, etc. Although a thing can also be used, the thing derived from the natural product obtained by decomposing | disassembling chitin is preferable.

  As an upper limit of the content of the N-acetylglucosamine in the oral composition, for example, 200 mg per soft capsule is preferable, 150 mg is more preferable, and 100 mg is still more preferable. On the other hand, as a minimum of the above-mentioned content of N-acetylglucosamine, 1 mg is preferred, for example, 5 mg is more preferred, and 10 mg is still more preferred. By setting the content of N-acetylglucosamine in the oral composition within the above range, N-acetylglucosamine has an anti-aging action on the skin, a cell activation action, a collagen production promoting action, a hyaluronic acid production promoting action, etc. It can be obtained effectively.

  In the oral composition, the content ratio of the [A] camellia seed extract and [B] N-acetylglucosamine is 50 parts by mass of [B] N-acetylglucosamine based on 100 parts by mass of [A] camellia seed extract. It is preferably 100 parts by mass or less, more preferably 60 parts by mass or more and 90 parts by mass or less, still more preferably 65 parts by mass or more and 85 parts by mass or less, and a blending ratio of 75 parts by mass. Is most preferred. By setting the content ratio of camellia seed extract and N-acetylglucosamine in the oral composition in the above range, the fibroblasts in the dermis can be more activated and the synthesis of collagen and hyaluronic acid can be promoted. As a result, symptoms such as wrinkles and sagging of the skin can be prevented or improved when the amount of synthesis exceeds the amount of collagen and hyaluronic acid contained in the dermis.

<Collagen>
Collagen is a commercially available ingredient. Collagen used in the oral composition includes, for example, those obtained by extracting from sebum and bone derived from animals such as cattle, pigs and chickens, and skin derived from fish. A collagen peptide obtained by treating bone, cartilage, or scale as a raw material by a conventional method, or a collagen peptide obtained by hydrolyzing the extract with an acid, alkali or enzyme, or a hot extract of collagen protein Some gelatin is also included. As these collagens, commercially available products may be used, one kind may be used alone, or two or more kinds may be used in combination. Among these, fish-derived collagen is preferable, and a collagen peptide obtained by hydrolyzing fish-derived collagen is more preferable. The molecular weight of the collagen peptide is preferably about 1,000 to about 100,000, more preferably about 5,000 to about 70,000 so that it can be effectively absorbed in the body.

  The upper limit of the collagen content in the oral composition is, for example, preferably 150 mg per soft capsule, more preferably 100 mg, still more preferably 80 mg. On the other hand, as a minimum of the above-mentioned content of collagen, for example, 1 mg is preferred, 5 mg is more preferred, and 10 mg is still more preferred. By setting the content of the collagen in the oral composition within the above range, the moisturizing action and the like of collagen can be effectively obtained.

  In the oral composition, the content ratio of the collagen to [A] camellia seed extract is such that the blending amount of collagen is 50 parts by mass or more and 100 parts by mass or less with respect to 100 parts by mass of [A] camellia seed extract. Preferably, it is 60 to 90 parts by mass, more preferably 65 to 85 parts by mass, and most preferably 75 parts by mass. By setting the content ratio of collagen in the oral composition in the above range, the fibroblast activation action of [A] camellia seed extract is further activated, and the synthesis of collagen and hyaluronic acid can be further promoted.

<Soy peptide>
Soy peptide is a component obtained by hydrolyzing protein contained in soybean. The method for preparing / obtaining soy peptide is not particularly limited. For example, after defatted soybeans to produce defatted soy milk, this can be processed as it is with a proteolytic enzyme, or further separated from soy protein. Can be obtained by enzymatic treatment. Moreover, the refined soybean peptide is also marketed and can be used conveniently.

  The upper limit of the soy peptide in the oral composition is, for example, preferably 100 mg per soft capsule, more preferably 80 mg, and still more preferably 50 mg. On the other hand, as a minimum of the above-mentioned content of soybean peptide, for example, 0.1 mg is preferred, 0.5 mg is more preferred, and 1 mg is still more preferred. By setting the content of the soy peptide in the oral composition within the above range, it is possible to effectively obtain a moisturizing action, an energy metabolism promoting action and the like possessed by the soy peptide.

  In the oral composition, the content ratio of the soybean peptide to the [A] camellia seed extract is 10 parts by mass or more and 40 parts by mass or less of the soybean peptide with respect to 100 parts by mass of the [A] camellia seed extract. It is preferably 15 parts by mass or more and 35 parts by mass or less, more preferably 20 parts by mass or more and 30 parts by mass or less, and most preferably 25 parts by mass. By setting the content ratio of soybean peptide in the oral composition within the above range, the fibroblast activation action of [A] camellia seed extract is more activated, and the synthesis of collagen and hyaluronic acid can be further promoted.

<Astaxanthin>
Astaxanthin is a pigment substance contained in the red meat portion of crustaceans and salmonids, and is a kind of carotenoid similar to β-carotene, lycopene and the like. Astaxanthin used in the oral composition may be any one as long as it is obtained according to a conventional method in addition to those derived from the natural product, and includes not only astaxanthin but also derivatives such as esters of astaxanthin. When separating astaxanthin from natural products, for example, red yeast Phaffia, Haematococcus algae, marine microorganisms, etc. are cultured and extracted from the culture with a solvent such as hexane or ethanol, or extracted with a solvent from krill or the like You can list things.

  The upper limit of the astaxanthin in the oral composition is, for example, preferably 100 mg, more preferably 80 mg, and even more preferably 50 mg per soft capsule. On the other hand, as a minimum of the above-mentioned content of astaxanthin, for example, 0.1 mg is preferred, 0.5 mg is more preferred, and 1 mg is still more preferred. By setting the content of the astaxanthin in the oral composition in the above range, the antioxidant action and the like possessed by astaxanthin can be effectively obtained.

  As the content ratio of the astaxanthin to the [A] camellia seed extract in the oral composition, the blending amount of astaxanthin is 5 parts by mass or more and 20 parts by mass or less with respect to 100 parts by mass of the [A] camellia seed extract. The amount is preferably 7 parts by mass or more and 18 parts by mass or less, more preferably 10 parts by mass or more and 15 parts by mass or less, and most preferably 12.5 parts by mass. By setting the content ratio of astaxanthin in the oral composition within the above range, the fibroblast activation action of [A] camellia seed extract is more activated, and the synthesis of collagen and hyaluronic acid can be further promoted.

<Optional component>
The oral composition further includes components used as pharmaceuticals, quasi drugs and food additives, such as vitamin E, excipients, sour agents, artificial sweeteners, flavoring agents, lubricants, coloring agents, increasing amounts. An agent or the like can be appropriately added within a range not impairing the effects of the present invention.

<Vitamin E>
Vitamin E is not particularly limited, and examples thereof include tocopherol and its derivatives, tocotrienol and its derivatives. Among these, one type may be used alone, or two or more types may be used in combination. Examples of tocopherol and its derivatives include dl-α-tocopherol, dl-β-tocopherol, dl-γ-tocopherol, dl-δ-tocopherol, dl-α-tocopherol acetate, nicotinic acid-dl-α-tocopherol, linol. Examples include acid-dl-α-tocopherol and dl-α-tocopherol succinate. In addition, as the tocopherol derivative, these acetates are preferably used. Examples of tocotrienol and derivatives thereof include α-tocotrienol, β-tocotrienol, γ-tocotrienol, and δ-tocotrienol. In addition, as the tocotrienol derivative, these acetates are preferably used. Note that tocotrienol is a tocopherol-like compound contained in wheat, rice bran, palm oil, and the like, and is a component having excellent antioxidant performance because it contains three double bonds in the side chain portion of tocopherol.

  As an upper limit of the content of the vitamin E in the oral composition, for example, 100 mg per soft capsule is preferable, 80 mg is more preferable, and 50 mg is still more preferable. On the other hand, as a minimum of the above-mentioned content of vitamin E, for example, 0.1 mg is preferred, 0.5 mg is more preferred, and 1 mg is still more preferred. By setting the content of vitamin E in the oral composition within the above range, the antioxidant action, blood circulation promoting action and the like of vitamin E can be effectively obtained.

  In the oral composition, the content ratio of the vitamin E to the [A] camellia seed extract is 5 parts by mass or more and 10 parts by mass or less based on 100 parts by mass of the [A] camellia seed extract. It is preferably 6 parts by mass or more and 9 parts by mass or less, and most preferably 7.5 parts by mass. By setting the content ratio of vitamin E in the oral composition within the above range, the fibroblast activation action of [A] camellia seed extract is more activated, and the synthesis of collagen and hyaluronic acid can be further promoted.

  The excipient is not particularly limited, and examples thereof include sucrose, lactose, glucose, corn starch, mannitol, crystalline cellulose, calcium phosphate, and calcium sulfate.

  Although it does not restrict | limit especially as said acidulant, For example, a citric acid (anhydrous citric acid), tartaric acid, malic acid etc. can be mentioned.

  The artificial sweetener is not particularly limited, and examples thereof include sodium saccharin, dipotassium glycyrrhizin, aspartame, stevia and thaumatin.

  Although it does not restrict | limit especially as said fragrance | flavor, Any of a synthetic | combination fragrance | flavor or a natural fragrance | flavor may be sufficient, for example, menthol, lemon, lime, orange, strawberry, etc. can be mentioned.

  The lubricant is not particularly limited, and examples thereof include magnesium stearate, sucrose fatty acid ester, polyethylene glycol, talc, hydrogenated vegetable oil, and the like. In addition, when polyethylene glycol is used as the lubricant, a stable solid agent can be obtained by suppressing the daily degradation of the active ingredient.

  Although it does not restrict | limit especially as said coloring agent, For example, what can be added to pharmaceuticals or foodstuffs, such as edible red No. 2, edible yellow No. 5, edible blue No. 2, can be mentioned.

  Although it does not restrict | limit especially as said bulking agent, For example, starch, D-mannitol, glucose, salt, etc. can be mentioned.

  The oral composition can be used as pharmaceuticals, quasi drugs and foods. What is necessary is just to determine suitably content, a dosage form, etc. of the said various components at the time of using the said oral composition for these uses according to a use. The oral composition can be used in any form such as a solid or liquid as a composition containing the above-mentioned various components. For example, it is processed into a form of a capsule (hard capsule, soft capsule), tablet, syrup, beverage or the like. Of these, a capsule form is preferable, and a soft capsule form is more preferable. The base material constituting the capsule of the capsule is not particularly limited, for example, gelatin derived from cow bone, cow skin, pig skin, fish skin, etc., seaweed derived components such as carrageenan, alginic acid, locust bean gum, guar gum, etc. Plant-derived components, pullulan, curdlan and other microorganism-derived components and components containing cellulose may be used as appropriate.

  When the oral composition is used as a food, for example, bread and confectionery such as bread, biscuits, candy and jelly; processed milk products such as yogurt and ham; seasonings such as miso, sauce, sauce and dressing; tofu and noodles Processed foods; processed oils and fats such as margarine, fat spread and shortening; powdered foods such as powdered drinks and powdered soups; supplement-type health foods such as capsules, tablets, powders and granules. Moreover, when using the said oral composition as a drink, adding to a sports drink, a fruit juice drink, a lactic acid bacteria drink, an alcoholic drink, a vitamin-mineral drink etc. is mentioned, for example. Furthermore, it can be added to processed milk, soy milk, beverages for improving the constitution, beverages combining natural materials that can be expected to have physiological effects, oral pharmaceuticals such as drinks, and the like. For example, when added to a soft drink, the necessary amount of the oral composition is added to the concentrate of the base beverage, mixed with stirring, then diluted with drinking water, and further diluted into a bottle or a plastic bottle. After filling in a packaging material such as the like, heat sterilization treatment may be appropriately performed.

  The oral composition can be used by any age regardless of gender, but particularly suitable for middle-aged men and women, for example, over 40 years old, who are worried about wrinkles and sagging. In addition to healthy people, people who have damaged skin (particularly the dermis) can also be used suitably.

  As a method for ingesting the oral composition, for example, when the above-mentioned various components are filled in soft capsules, it is sufficient to ingest about 3 capsules a day, and it is more preferable to ingest 1 capsule in the morning and 2 in the evening. This is because skin metabolism becomes most active from about 8 pm to about 4 am.

  “Beautiful skin” in the present invention refers to preventing or improving wrinkles and sagging, as well as improving skin tension, elasticity, and transparency, and preventing or suppressing skin roughness, dullness, spots and freckles. , Skin texture, improving makeup, etc. are included.

  In addition, “prevention” in the present invention includes not only completely suppressing wrinkles and sagging, but also suppressing the progression of symptoms such as wrinkles and sagging, and “improvement” completely eliminates wrinkles and sagging. In addition to resolving these problems, alleviating these symptoms should be included.

  EXAMPLES Hereinafter, although this invention is explained in full detail based on an Example, this invention is not interpreted limitedly based on description of this Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Production Example 1]
Each component was mixed according to the following formulation and filled into gelatin capsules by a conventional method to prepare a supplement.

<Test Example 1: Amount of change in moisture and oil (Part 1)>
Taking 10 females in their 40s as subjects, taking the supplement obtained in Production Example 1 twice a day (1 in the morning and 2 before going to bed at night) for 3 weeks, The amount and the oil content were measured, and the average value of the rate of change was calculated. The moisture was measured using Corneometer (registered trademark) CM825 (Integral Co., Ltd.), and the oil content was measured using Sebumeter (registered trademark) SM815 (Integral Co., Ltd.). The results are shown in Table 2 below.

<Test Example 2: Amount of change in moisture and oil content (2)>
Taking 10 women in their 40s as subjects, taking the supplement obtained in Production Example 1 twice a day (1 in the morning, 2 before going to bed at night) for 4 weeks, and not taking the supplement The period was set for 2 weeks. The moisture content and oil content of the skin were measured every two weeks before the start of ingestion, and the average value of the rate of change was calculated. In addition, the water | moisture content and the oil content were measured using the apparatus similar to the said Test Example 1. The results are shown in Table 3 below.

  From Table 2 above, it can be seen that the moisture content and oil content of the skin increase by taking the supplement obtained in Production Example 1 twice a day. Therefore, the supplement of this invention can be used suitably for the replenishment of the water | moisture content and oil content to the skin which is lacking in a water | moisture content and oil content for reasons, such as aging. In addition, from Table 3 above, after taking the supplement continuously for 4 weeks, although the water content of the skin gradually decreases for 2 weeks even after stopping the intake of the supplement, It turns out that it is rising as it is. Therefore, it is presumed that the supplement of the present invention can be obtained with a constant effect even if the period of continuous administration and the period of non-taking are alternately provided.

<Test Example 3: Skin beautifying effect>
Taking 10 females in their 20s to 60s as subjects, the following supplements A to C were taken twice a day (1 in the morning and 2 before going to bed at night) for 1 month. The change to was investigated. The appearance of supplements A to C is the same, and after taking supplement A continuously for one month, before taking the next supplement B, the period of not taking supplements is one month. It was set up.

  The evaluation of the skin condition (moist feeling, texture, tension, etc.) after taking the supplement continuously for one month was evaluated based on the following evaluation point criteria. Subsequently, the average of each evaluation score was calculated.

(Evaluation criteria for skin condition)
5 points: Very good.
4 points: Improved.
3 points: No change.
2 points: Deteriorated.
1 point: Very worse.

(result)
The results of the evaluation are shown in Table 5 below.

  After taking supplement A containing only camellia seed extract powder, for example, the skin feels somewhat moist, the skin feels better, etc. I couldn't get much feeling. Moreover, after ingesting supplement B containing camellia seed extract powder and N-acetylglucosamine, in addition to the real feeling that the skin is moist, for example, the skin has become glossy, the concrete has improved Improvement effect was obtained. Furthermore, after ingesting supplement C containing camellia seed extract powder, N-acetylglucosamine and astaxanthin, the skin tension, luster and texture were improved, rough skin and spots disappeared, and the makeup was improved. All subjects were able to improve the skin condition surely, including swelling, soft joint pain, and light eye strain.

<Test Example 4: Hair growth, hair growth, hair nourishing action>
Similar to Test Example 1 above, each of 10 subjects continuously ingested three types of supplements for one month, and the hair condition (hair growth, hair growth, hair nourishing action) after ingestion was evaluated. Evaluation was performed based on the above evaluation point criteria. Subsequently, the average of each evaluation score was calculated. The evaluation results are shown in Table 6 below.

  After taking supplement A and supplement B, there was not much change in hair, whereas after taking supplement C containing camellia seed extract powder, N-acetylglucosamine and astaxanthin, hair loss decreased. In addition, hair growth, hair growth, and nourishing effects were obtained for all the subjects, such as tension and stiffness on the hair, thick hair, increased elasticity of the hair, and increased number of hairs.

  The oral composition can promote the production of collagen and hyaluronic acid by activating the fibroblasts contained in the dermis, and can effectively prevent or improve wrinkles and sagging, etc. In addition, the effect of preventing or improving joint pain, fatigued eyes, and the effect of promoting hair elongation can be obtained.

Claims (5)

[A] containing camellia seed extract, and [B] N-acetylglucosamine,
[A] The oral composition whose compounding quantity of [B] N-acetylglucosamine with respect to 100 mass parts of camellia seed extract is 50 to 100 mass parts.   Furthermore, the oral composition of Claim 1 containing 1 type, or 2 or more types selected from the group which consists of collagen, a soybean peptide, and an astaxanthin.   The oral composition according to claim 1, which is a skin beautification promoter.   The oral composition according to claim 1 or 2, which is a hair growth, hair growth and / or hair nourishing agent.   The [A] camellia seed extract of 100 mg / kg body weight or more and 150 mg / kg body weight or less is used so that it is orally administered to a human per day. Oral composition as described in.