KR20170030583A - Composition for preparing carbon dioxide formulation for external use, method for producing same, method for evaluating same, and carbon dioxide formulation for external use - Google Patents

Abstract

Disclosed is a composition for preparing a carbon dioxide external preparation which can be peeled off without leaving a composition for preparing a carbon dioxide external preparation in the skin until the end of use, Another object of the present invention is to provide a novel composition for preparing a carbon dioxide external preparation for generating a film-permeable carbon dioxide in an amount exceeding that of a film-permeable carbon dioxide generated from a composition for preparing a carbon dioxide external preparation containing components known from the prior art . It is another object of the present invention to provide a carbon dioxide external preparation and a cosmetic pack obtained from the composition for preparing a novel external preparation for carbon dioxide. A composition for preparing a carbon dioxide external preparation comprising as essential components at least a magnesium salt, a water-soluble calcium salt, a gelling agent gelled by a magnesium ion or a calcium ion, a carbonate, a substance capable of hydrolyzing and generating an acid, a polyhydric alcohol and water.

Description

FIELD OF THE INVENTION [0001] The present invention relates to a composition for preparing a carbon dioxide external preparation, a method for producing the carbon dioxide external preparation, a method for producing the carbon dioxide external preparation,

The present invention relates to a composition used for preparing a carbon dioxide external preparation for mixing two or more agents at the time of use.

There is known a technique for producing a carbonic acid gas by mixing a basic composition containing a carbonate with an acidic composition such as water-soluble acid in the presence of water for the purpose of cosmetic and medical effects (see Patent Document 1, etc.).

In addition, by using a substance that hydrolyzes to generate an acid, a carbonate, a thickener, water, a gelling agent that gels by calcium ions, and a water-insoluble or water-insoluble calcium salt as essential components, carbon dioxide is continuously absorbed percutaneously and lightly It is also known that a carbon dioxide external preparation having a stronger cosmetic and medical effect can be easily prepared (see Patent Document 2, etc.).

The composition for preparing a carbon dioxide external application agent is to mix and react two or more agents when they are used to generate carbon dioxide.

When a composition for preparing a carbon dioxide external preparation is used for a cosmetic pack, a gelling agent which is gelled by calcium ions and a water-insoluble or water-soluble calcium salt are added to a composition for preparing a carbon dioxide external preparation, It is known that it is possible to solidify a composition for use.

However, there has been a problem that the rate of gelation of the composition for preparing a carbon dioxide external preparation and the hardness of the gel are not suitable due to the kind and the blending ratio of the gelling agent and the water-insoluble or water-soluble calcium salt. That is, when the gelation is too fast, the composition for preparing a carbon dioxide external preparation has a problem that spreading on application to skin or the like is poor and sufficient carbon dioxide can not be generated. On the other hand, if the gelation is too slow, the composition for preparing a carbon dioxide external preparation can not be cleanly removed from the surface of the skin by hand, and it is difficult to use the composition as a pack.

Patent Document 1: Japanese Patent Publication No. 4248878 Patent Document 2: Japanese Patent Publication No. 4595058

The present invention relates to a method for preparing a composition for external application of a carbon dioxide which is spread well on application to a skin or the like immediately after mixing two or more agents and which contains more permeable carbon dioxide than the amount of the permeable carbon dioxide generated from a conventionally- And a composition for the preparation of a novel external preparation for carbon dioxide which is hardened until the elapse of use time. It is another object of the present invention to provide a carbon dioxide external preparation and a cosmetic pack obtained from the composition for preparing a novel external preparation for carbon dioxide.

As a result of intensive studies in view of the above circumstances, the present inventors have found that a gelling agent which is gelled by a magnesium salt, a water-soluble calcium salt, a magnesium ion or a calcium ion, a carbonate, a substance which generates an acid by hydrolysis, a polyhydric alcohol, By weight based on the total weight of the composition.

According to the present invention, by containing a magnesium salt, a water-soluble calcium salt, a gelling agent gelled by a magnesium ion or a calcium ion, a carbonate, a substance which generates a hydrolyzed acid, a polyhydric alcohol and water, When the composition for preparing a carbon dioxide external preparation for external use is divided into two or more parts so as to separately form an acid-generating substance, the composition for preparing a carbon dioxide external preparation is applied to the skin, It is possible to provide a composition for preparing a carbon dioxide external preparation for use in which the surface of the coating is not hardened in a state in which it is not adhered, and is gelled so that the composition for preparing a carbon dioxide external preparation can be peeled off without remaining on the skin. That is, it is possible to provide a composition for preparing a carbon dioxide external-use agent which is spread when the composition for preparing a carbon dioxide external-use agent is applied to the skin or the like and is hardened to a degree that can be peeled by hand after a lapse of use time.

Further, according to the composition for preparing a carbon dioxide external preparation for use in the present invention, by containing a magnesium salt, a water-soluble calcium salt, a gelling agent gelled by a magnesium ion or calcium ion, a carbonate, a substance generating an acid by hydrolysis, a polyhydric alcohol, Permeable carbon dioxide in an amount exceeding the amount of the film-permeable carbon dioxide generated from the composition for preparing a carbon dioxide external-use agent, which is composed of a component known as Patent Document 2, can be produced.

Fig. 1 is a graph showing changes in film-permeable carbon dioxide generation amount with time in Example 1 and Comparative Example 3. Fig.
2 is a graph showing changes in pH value with time in Example 1 and Comparative Example 3. Fig.

The composition for preparing a composition for external preparation for carbon dioxide of the present invention is a composition for preparing a carbon dioxide external preparation for mixing two or more agents at the time of use and includes a magnesium salt, a water-soluble calcium salt, a gelling agent gelled by a magnesium ion or a calcium ion, A substance which is decomposed to generate an acid, a polyhydric alcohol and water, and may further contain other components as necessary.

The magnesium salt is not particularly limited as long as it has magnesium in its chemical structural formula and generates magnesium ion in water, and can be appropriately selected according to the purpose. Magnesium stearate, magnesium hydroxide, magnesium acetate, magnesium malate, magnesium citrate, and the like may be added to the aqueous solution of the metal salt, for example, magnesium oxide, magnesium carbonate, magnesium sulfate, magnesium aluminosilicate, magnesium L- . These may be used singly or in combination of two or more kinds, and may also serve as other essential components such as carbonate. Among them, magnesium carbonate and magnesium oxide are preferable, and magnesium carbonate which also serves as a carbonate which is essential as a component of a composition for preparing a carbon dioxide external preparation is more preferable.

The content of the magnesium salt in the total amount of the composition for preparing a carbon dioxide external preparation for use in the present invention is not particularly limited and may be appropriately selected according to the purpose. When the content is more than 12 mass%, the time for hardening of the coated surface may be too short, and the time for hardening the entire gel to be able to peel off the entire gel is also too short. On the other hand, if the content is less than 0.3% by mass, the time for hardening of the applied surface is too long, and the time for solidifying the gel to such an extent that it does not leave the entire gel on the skin becomes too long, so that the content is preferably not less than 0.3% by mass and less than 12% , And more preferably 0.5 mass% or more and 11 mass% or less.

The water-soluble calcium salt is not particularly limited as long as it has calcium in its chemical structure and is water-soluble and generates calcium ions in water, and can be appropriately selected according to the purpose. Examples thereof include calcium chloride and calcium lactate. These may be used singly or in combination of two or more, and they may also serve as other essential components. Among them, a calcium salt which is gelled by hand to allow separation of the composition for preparing a carbon dioxide external preparation by the end of use is preferable, and calcium chloride is more preferable in view of solubility in water.

The content of the water-soluble calcium salt (excluding water in the water-soluble calcium salt) with respect to the total amount of the composition for preparing a carbon dioxide external preparation is not particularly limited and may be appropriately selected according to the purpose. When the content is less than 0.003 mass%, the composition for preparing a carbon dioxide external preparation does not gel sufficiently until the end of the use time, making it difficult to peel off. On the other hand, when the content is more than 0.05% by mass, the coating surface tends to harden from mixing to coating, so that the content is preferably 0.003% by mass or more and 0.05% by mass or less, more preferably 0.003% by mass or more and 0.03% by mass or less.

The gelling agent gelled by the magnesium ion or calcium ion is not particularly limited as long as it is gelled by magnesium ions generated from the magnesium salt or calcium ions generated from the water-soluble calcium salt, and can be appropriately selected according to the purpose. Examples thereof include carrageenan, xanthan gum, tara gum, sodium alginate and the like. These may be used alone or in combination of two or more. Of these, sodium alginate and xanthan gum are preferable in terms of smoothness of application and ease of use.

The content of the gelling agent gelled by the magnesium ion or calcium ion in the total amount of the composition for preparing a carbon dioxide external preparation is not particularly limited and may be appropriately selected depending on the purpose. When the content is less than 1.0% by mass, the composition for preparing a carbon dioxide external preparation is not sufficiently geled, and it becomes difficult to obtain an effect as an external preparation for skin. On the other hand, if it exceeds 7% by mass, the coated surface tends to be hardened in a state in which the composition for preparing a carbon dioxide external-use agent does not adhere to the hands which have come into contact with the coated surface from mixing to coating, More preferably 2% by mass or more and 5% by mass or less.

The carbonate is not particularly limited as long as it is hydrolyzed in the composition for preparing a carbon dioxide external preparation and reacts with a substance generating an acid to generate carbon dioxide, and can be appropriately selected according to the purpose. Examples thereof include ammonium carbonate, ammonium hydrogencarbonate, potassium carbonate, potassium hydrogencarbonate, sodium carbonate, sodium hydrogencarbonate, magnesium carbonate, magnesium hydrogencarbonate, calcium carbonate, calcium hydrogen carbonate and barium carbonate. These may be used singly or in combination of two or more, and may also serve as other essential components such as a magnesium salt and a calcium salt. Among them, magnesium carbonate which also serves to generate magnesium ions is more preferable.

The content of the carbonate in the total amount of the composition for preparing a carbon dioxide external preparation for use in the present invention is not particularly limited and may be appropriately selected according to the purpose. If the content is less than 0.3% by mass, the amount of generated carbon dioxide is reduced, and the effect as an external preparation obtained by carbon dioxide generation is not sufficiently exhibited. On the other hand, when the content is more than 12% by mass, the carbon dioxide generated due to the high pH of the composition for preparing a carbon dioxide external preparation is liable to exist as carbonates and the amount of the permeable carbon dioxide generated is reduced. By mass or less, more preferably 0.5% by mass or more and 11% by mass or less.

The substance capable of hydrolyzing and generating an acid is not particularly limited as long as it has at least one cyclic ester bond in its molecular structure and can be appropriately selected according to the purpose. D, L- or L-lactide (3,6-dimethyl-1,4-dioxane-2,5-dione), D, L- or L-glycolide, phthalic anhydride, maleic anhydride, succinic anhydride and the like. These may be used alone or in combination of two or more. Among them, glucono delta lactone and D, L-lactide are preferable, and glucono delta lactone is more preferable in view of the rate of hydrolysis and the rate of production of an acid reacting with a carbonate and the availability of a compound.

The content of the substance that hydrolyzes and generates an acid with respect to the total amount of the composition for preparing a carbon dioxide external preparation for use in the present invention is not particularly limited and may be appropriately selected depending on the purpose. If the content is less than 10% by mass, the amount of carbon dioxide generated by the reaction between the hydrolyzed acid and the carbonate is reduced, and the effect as an external preparation obtained by carbon dioxide generation becomes difficult to be sufficiently exhibited. On the other hand, when the content exceeds 20 mass%, it becomes difficult to stir and mix with other components, and therefore, it is preferably 10 mass% or more and 20 mass% or less, and more preferably 13 mass% or more and 18 mass%.

The polyhydric alcohol is not particularly limited as long as it is an alcohol having two or more hydroxyl groups in its molecular structure and can be appropriately selected according to the purpose. Examples thereof include glycerin, which is also ethylene glycol, propylene glycol, 1,3-butyleneglycol, polyethylene glycol, glycerin, 1,8-octanediol, and sugar alcohol, Tall, and also trehalose, which is also a sugar. These may be used alone or in combination of two or more. Among them, 1,3-butyleneglycol is preferred from the viewpoint of the effect of shortening the gelation time and the moisturizing effect.

The content of the polyhydric alcohol relative to the total amount of the composition for preparing a carbon dioxide external preparation for use in the present invention is not particularly limited and may be appropriately selected depending on the purpose. If the content is less than 5% by mass, the composition for preparing a carbon dioxide external preparation becomes long after the mixing of two or more components, and the composition for preparing a carbon dioxide external preparation can not be gelled by hand until the end of use . On the other hand, when the content is more than 25 mass%, the coating surface is hardened in a state in which the composition for preparing a carbon dioxide external-use agent is not adhered to the hand contacting the coating surface from mixing to coating, Or less, more preferably 5 mass% or more and 20 mass% or less.

The water contained in the above composition for preparing a carbon dioxide external preparation is not particularly limited as long as it is water used for ordinary cosmetics and medicines, and can be appropriately selected according to the purpose. For example, distilled water, membrane permeated water, and ion exchange water can be mentioned. These may be used singly or in combination of two or more, or as an aqueous solution of other components such as an aqueous solution of calcium chloride.

The content of the water with respect to the total amount of the composition for preparing a carbon dioxide external preparation for use in the present invention is not particularly limited and may be appropriately selected depending on the purpose. The content is the sum of the water and the water contained in the other components such as the water-soluble calcium salt, and is adjusted so that the total amount of the composition for preparing a carbon dioxide external-use agent is 100% by mass. If the content is less than 55 mass%, the viscosity tends to be high and the fluidity, flexibility, and solubility of other components are lost. Therefore, the content is preferably 55 mass% or more.

The other components of the composition for preparing a carbon dioxide external preparation are not particularly limited as long as they are components used in cosmetics or external dermatological preparations and can be appropriately selected according to the purpose. Examples thereof include a surfactant, a pH adjuster, a moisturizer, an antiseptic, an antioxidant, a perfume, a dispersant, an ultraviolet absorber, and a pigment. These may be used singly or in combination of two or more.

The mode of use of the carbon dioxide external application agent is not particularly limited and can be appropriately selected depending on the purpose. For example, a form to be used by mixing two or more agents on a gel on the skin or the like, a form to be used by mixing two or more agents in a gel phase and a granular phase upon application to a skin or the like, And a form in which the agent is dissolved by dissolving it in water and then mixed with a gel agent at the time of application to a skin or the like.

The method for evaluating the excellence of the spreading of the composition for preparing a carbon dioxide external preparation when applied to skin or the like is not particularly limited and may be selected according to the purpose as long as it can demonstrate the excellence of spreading of the coated gel. For example, it is defined as "the time until the surface of the applied gel begins to harden" when the two or more agents are blended and then applied with the skin or the like and then " And a method of evaluating the excellence of spreading by the short and long time of "the time at which the application surface starts to harden".

The method for evaluating the ease of peeling at the end of use after application of the composition for preparing a carbon dioxide external preparation for skin to skin or the like is not particularly limited as long as it can exhibit ease of peeling of the coated gel and easiness of curing, You can choose to follow. For example, when two or more agents are mixed and then applied with a skin or the like, the time until the gel is not left on the skin when the gel is removed is defined as "a time to peel off" Quot; time "is compared with the use time.

The method for evaluating the amount of the film-permeable carbon dioxide generated in the composition for preparing a composition for external preparation for carbon dioxide is not particularly limited as far as it can measure the amount of carbon dioxide permeating the membrane imitating human skin environment. . For example, there is a method of immersing a porous polymer membrane in oil (fat) and measuring the amount of carbon dioxide permeated through the membrane. A microporous film (3M microporous film, 3M microporous film, manufactured by Sumitomo 3M Ltd., pore diameter of 0.3 탆 or less) was used for the porous polymer membrane and olive squalene (manufactured by Kishimoto Tokushu Kaneko Kogyo Co., , Plant squalene), and a method of using a carbon dioxide gas concentration meter (product number: CGP-31, manufactured by DOKAI Co., Ltd.) is particularly preferable for the measurement of the amount of permeated carbon dioxide.

Specifically, the amount of the membrane-permeable carbon dioxide generated in the composition for preparing a composition for external preparation for carbon dioxide was evaluated by 1 g of a gel obtained by stirring and mixing two or more agents into a container dedicated to a carbon dioxide gas concentration meter and 0.1 g of olive squalene The coated microporous film is put on the container, and a detector of a carbon dioxide gas concentration meter is mounted in the dedicated container. A predetermined amount of water is added using a syringe to fill the space between the container and the detector, and immediately after that, the permeable carbon dioxide generation amount is measured and recorded for 60 minutes every minute.

As a method of evaluating the composition for preparing a carbon dioxide external preparation, it is possible to confirm the state of carbon dioxide generated from the composition for preparing a carbon dioxide external preparation by further measuring the pH of the composition for preparing a carbon dioxide external preparation at the time of generating the membrane permeable carbon dioxide .

The method of measuring the pH is not particularly limited as long as the change in pH over time of the composition for preparing a carbon dioxide external preparation can be measured and can be appropriately selected according to the purpose. For example, a method of aging mixing two or more agents and measuring the pH of a composition for preparing a carbon dioxide external preparation with a lapse of time using a water-proof type pH meter (HANNA instruments, pHep4 HI98127).

Example

Hereinafter, the present invention will be specifically described with reference to examples and comparative examples, but the present invention is not limited to these examples.

(Examples 1 to 9 and Comparative Examples 1 to 3)

According to the composition shown in Table 1, a composition for preparing a carbon dioxide external preparation was prepared. In the examples in which the magnesium salt and the magnesium carbonate serving also as the carbonate were mixed, the composition for preparing the carbon dioxide external preparation was prepared in the form of the magnesium carbonate in the formulations shown in the table. However, , It was considered that the magnesium salt and the carbonate were respectively mixed in the same amount.

According to the blending amounts shown in Table 2, the two divided products were stirred and mixed until they were uniformly observed from the naked eye just before use.

The composition for preparing a carbon dioxide external preparation for use in Examples 1 to 9 and Comparative Examples 1 to 3 was evaluated for the composition for preparing a carbon dioxide external preparation by the following evaluation method, And the ease of peeling at the end of use was evaluated.

The time until the gel is no longer attached to the finger when the application surface is contacted is "the time at which the application surface begins to harden" after the two or more agents are mixed and applied with skin or the like, Time to start hardening ". Next, two or more agents are mixed and applied with the skin, and then the "time until the gel is not left on the skin when it is removed" is set as the "time to peel off" and the "time to peel off" . Then, based on the time of applying the two or more agents after mixing with the skin or the like, a proper "time to start hardening of the application surface" is defined and an appropriate "time to peel off" is specified based on the use time. (?) "When both the " time at which the application surface starts to harden" and the time at which it can be removed are within the specified time, and " Quot ;, and when the one side is within the specified time and the other side is not within the specified time, it is evaluated as "normal (O) ", and when it is not hardened even after 60 minutes from mixing or can not be removed, ) ".

In the examples and the comparative examples described above, since the time for applying the two or more agents of the composition for preparing a carbon dioxide external preparation was mixed with the skin or the like was within 5 minutes, the time for starting the hardening of the appropriate applied surface was 5 to 10 minutes did. In addition, in the examples and comparative examples described, the use time of the composition for preparing a carbon dioxide external preparation was 10 to 15 minutes, and therefore, the appropriate time for peeling was specified to be 10 to 15 minutes.

Table 3 shows the evaluation results of the excellence of spreading upon application to the skin after mixing and the ease of peeling at the end of use.

As can be seen from Table 3, in Comparative Example 2 in which the water-soluble calcium salt is not contained, it can not be removed after the end of use as compared with Examples 1, 2 and 6 which were excellent (?) Evaluation. In Examples 3 and 4, it was found that the spreading time at the time of coating was poor because the time for starting the hardening of the coated surface was short. In Comparative Example 1 in which magnesium carbonate was changed to sodium hydrogen chloride, in Examples 7 and 8 in which the coating surface and the amount of magnesium carbonate were increased, the time for starting the hardening of the coated surface was also deteriorated And it became shorter.

For the composition for preparing a carbon dioxide external preparation for use in Example 1 and Comparative Example 3, the amount of permeable carbon dioxide generated was evaluated by the following method.

For the Examples and Comparative Examples, a microporous film coated with 0.1 g of olive squalene was placed on a container for exclusive use with a carbon dioxide gas concentration meter, in which 1 g of the gel obtained by mixing the two agents described in Table 2 was applied, A detector of a carbon dioxide gas concentration meter is mounted. A predetermined amount of water was added using a syringe to fill the gap between the container and the detector, and the amount of permeated carbon dioxide generated was measured and recorded every minute for 60 minutes immediately thereafter.

The test results of the transmissible carbon dioxide generation amount are shown in Table 4.

Based on Table 4, changes over time in the amount of membrane permeable carbon dioxide generated in Example 1 and Comparative Example 3 are shown in Fig.

From Table 4 and FIG. 1, it can be seen that when Example 1 is compared with Comparative Example 3 which does not contain magnesium ion and water-soluble calcium salt, the permeable carbon dioxide in the up to 15 minutes, Permeable carbon dioxide generated in Comparative Example 3. The amount of the generated carbon dioxide was about 1.2 times that of the membrane permeable carbon dioxide of Comparative Example 3. [

The pH was measured by the following method. The two agents described in Example 1 and Comparative Example 3 were mixed with stirring, and the pH of the composition for preparing a carbon dioxide external preparation was measured with the passage of time using a waterproof type pH meter (HANNA instruments, pHep4 HI98127).

The measurement results of the pH are shown in Table 5 and FIG.

It can be seen from Table 5 and FIG. 2 that in Example 1, the pH was maintained at pH 4.0 to 6.5, which is liable to generate membrane-permeable carbon dioxide, until the pH dropped immediately after mixing of the two agents and elapsed for 60 minutes there was.

It is apparent from Tables 3 to 5 and Figs. 1 and 2 that when the composition for preparing the above-mentioned external preparation for carbon dioxide which is divided into two or more parts is applied on the skin after mixing, the composition for preparing a carbon dioxide external preparation It is possible to provide a composition for preparing a carbon dioxide external preparation for use in which the surface to be coated is not hardened and the composition for preparing a carbon dioxide external-use agent is manually peeled off until the end of use. That is, it was found that when the composition for preparing a carbon dioxide external preparation was spread on skin or the like, it spread well and hardened to a degree that it could be peeled by hand after a lapse of use time.

The composition for preparing a carbon dioxide external preparation for use in the present invention may contain at least one selected from the group consisting of a magnesium salt, a water-soluble calcium salt, a gelling agent gelled by a magnesium ion or calcium ion, a carbonate, a substance which generates an acid by hydrolysis, a polyhydric alcohol, Permeable carbon dioxide generated from a composition for preparing a carbon dioxide external-use preparation which is maintained at a pH of 4 to 6.5 and which is known from Patent Document 2 in a period from immediately after use to end of use, Permeable carbon dioxide was generated.

The above effects are based on several factors. First, the above effect is based on the fact that the ionic crosslinking of a gelling agent such as sodium alginate or xanthan gum is slowed by the addition of a component that generates magnesium ions such as magnesium carbonate, do. The combination of magnesium ions improves the spreading of the composition for preparing a carbon dioxide external preparation immediately after mixing and contributes to solidification of the entire gel. The above effect can be further improved by adding calcium chloride, which is a water-soluble calcium salt, as a component for generating calcium ions, to ion bridging of a gelling agent such as sodium alginate or xanthan gum, Based on that. The mixing of the water-soluble calcium ions contributes to hardening the application surface of the composition for preparing a carbon dioxide external preparation immediately after mixing. The above effect is based on the fact that by increasing the amount of the butylene glycol, which is a polyhydric alcohol, ion crosslinking of the gelling agent can be accelerated. The combination of butyleneglycol contributes to the control of the excellence of the spreading of the composition for preparing a carbon dioxide external preparation immediately after mixing and the detachable time.

The above effect is obtained by adjusting the time at which the surface of the coated layer starts to harden and the time at which it can be peeled by adjusting an appropriate amount of a component for generating magnesium ions such as magnesium carbonate and a water-soluble calcium salt to generate from the composition for preparing a carbon dioxide external preparation Permeable carbon dioxide can be released to the outside of the composition for preparing a carbon dioxide external preparation. The combination of a suitable amount of the magnesium ion-generating component and the water-soluble calcium salt may be a combination of a water-insoluble or water-insoluble calcium salt as a component for generating calcium ions in an appropriate amount and a component known in the art that does not contain a component that generates magnesium ions Permeable carbon dioxide can be generated more than the amount of the membrane permeable carbon dioxide generated from the composition for preparing a carbon dioxide external application agent.

The composition for preparing a composition for external preparation for carbon dioxide of the present invention can be easily mixed and prepared in a ratio of 2 or more and can be spread easily after mixing and hardly spread on the surface of the skin until it is applied to the skin, Permeable carbon dioxide, and can continue to generate a sufficient amount of membrane permeable carbon dioxide within the use time. Therefore, in the cosmetic pack which can appropriately stimulate the skin, it spreads well at the time of application, can be removed cleanly at the end, and also has an effect as a so-called carbonic acid gas pack. And it can be suitably used for any of quasi drugs such as cosmetics, external preparations for skin, hair preparations, medicines, and pet products.

The composition for preparing a carbon dioxide external preparation for use in the present invention is characterized in that it is not compatible with a so-called carbonic acid gas pack on a gel in the cosmetics industry, spreads at the time of application and can be removed at the end of use. Therefore, it is necessary to wipe out a less hard gel that has not been removed at the time of use end so as to use a towel. In addition, a secondary problem has also arisen in the washing treatment of the towel in which the less hard gel is wiped. However, It is also a task to solve.

Claims (7)

A composition for preparing a carbon dioxide external preparation comprising, as essential components, at least a magnesium salt, a water-soluble calcium salt, a gelling agent gelled by a magnesium ion or a calcium ion, a carbonate, a substance generating an acid by hydrolysis, a polyhydric alcohol and water. The method according to claim 1,
When the composition for preparing a carbon dioxide external preparation for external use divided into two or more so that at least the carbonate and the hydrolyzed acid generating substance are separately blended is applied on the skin after mixing, the application surface is not hardened from mixing to application, And the composition for preparing a carbon dioxide external preparation is gelled in a releasable manner from the skin until the end of use. The method according to claim 1 or 2,
Permeable carbon dioxide generation amount in the case where the water-soluble calcium salt is changed to a water-insoluble or water-insoluble calcium salt except for the magnesium salt is exceeded Wherein the magnesium salt and the water-soluble calcium salt are mixed with each other to prepare a composition for external preparation for carbon dioxide. The method according to any one of claims 1 to 3,
Wherein the content of the magnesium salt relative to the total amount of the composition for preparing a carbon dioxide external preparation is from 0.3% by mass to 12% by mass and the content of the water-soluble calcium salt is from 0.003% by mass to 0.05% by mass, And the content of the gelling agent gelled by the magnesium ion or calcium ion with respect to the total amount of the composition for preparing a carbon dioxide external preparation is not less than 1.0% by mass and not more than 7% by mass, Wherein the content of the carbonate is 0.3% by mass or more and 12% by mass or less, and the content of the hydrolyzed acid generating substance with respect to the total amount of the composition for preparing a carbon dioxide external preparation is 10% by mass or more and 20% by mass or less, The content of the polyhydric alcohol relative to the total amount of the composition for preparing a composition for external use for carbon is not less than 5% by mass and not more than 25% Wt% or less, the composition for a carbon dioxide external preparation prepared. A pharmaceutical composition according to any one of claims 1 to 4, which comprises at least a magnesium salt, a water-soluble calcium salt, a gelling agent gelled by a magnesium ion or a calcium ion, a carbonate, a substance generating an acid by hydrolysis, a polyhydric alcohol, By weight based on the total weight of the composition. A carbon dioxide external preparation using the composition for preparing a carbon dioxide external preparation according to any one of claims 1 to 4. A cosmetic pack using the composition for preparing a carbon dioxide external preparation according to any one of claims 1 to 4.

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