JP4756265B2 - Carbon dioxide external agent stripping removal method and divalent cation-containing aqueous solution used therefor - Google Patents
Carbon dioxide external agent stripping removal method and divalent cation-containing aqueous solution used therefor Download PDFInfo
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本発明は、二酸化炭素外用剤剥離除去方法及びそれに用いる二価陽イオン含有水性溶液に関する。 The present invention relates to a carbon dioxide external agent exfoliation and removal method and a divalent cation-containing aqueous solution used therefor.
二酸化炭素の外用による美容もしくは医療効果を簡便に得るために、炭酸ガスを配合した二酸化炭素外用剤や、用時調製により炭酸ガスを発生させる二酸化炭素外用剤が提案されている。例えば、水溶性酸、増粘剤、水溶性分散剤を必須成分とし、増粘剤が水溶性酸及び水溶性分散剤と混合されている粒状物と、炭酸塩、水、増粘剤を必須成分とし、使用時に粒状物と混合する粘性組成物とからなり、二酸化炭素外用剤を短時間で容易に調製できる二酸化炭素外用剤調製用組成物が提案されている（特許文献１）。 In order to easily obtain the beauty or medical effect by the external use of carbon dioxide, a carbon dioxide external preparation containing carbon dioxide and a carbon dioxide external preparation that generates carbon dioxide by preparation at the time of use have been proposed. For example, water-soluble acid, thickener, water-soluble dispersant are essential ingredients, and the thickener is mixed with water-soluble acid and water-soluble dispersant, and carbonate, water, thickener are essential. A composition for preparing a carbon dioxide external preparation, which comprises a viscous composition mixed as a component with a granular material at the time of use and can easily prepare a carbon dioxide external preparation in a short time, has been proposed (Patent Document 1).
上記二酸化炭素外用剤調製用組成物により調製された二酸化炭素外用剤は、効果発現が早く美容及び医療効果が強力であるものの、炭酸塩と酸が急激に反応するため、発生した二酸化炭素がゲル中に気泡化したり、あるいは大気中に散逸したり、さらには原料の種類、配合割合などによってはゲル化が完了する前に二酸化炭素の発生が完了してしまうなどの問題点があった。 Although the carbon dioxide external preparation prepared by the above composition for preparing carbon dioxide external preparation has a rapid onset of effects and a strong beauty and medical effect, the generated carbon dioxide gels because the carbonate and acid react rapidly. There is a problem that bubbles are generated inside or dissipated into the atmosphere, and further, generation of carbon dioxide is completed before gelation is completed depending on the kind and blending ratio of raw materials.
そのことから、さらに上記とは別の二酸化炭素外用ゲル調製用組成物、すなわち、ゲルに二酸化炭素が実質的に非気泡状態で溶解してなる二酸化炭素外用ゲルの調製に用いられ、弱酸と、カルシウムイオン捕捉剤とを必須成分とする粒状物（Ａ）と、この粒状物（Ａ）と混合する、炭酸カルシウムと、カルシウムイオンによりゲル化するゲル化剤と、水とを必須成分とする粘性物（Ｂ）と、からなることを特徴とする二酸化炭素外用ゲル調製用組成物が提案されている（特許文献２）。 Therefore, a composition for preparing a carbon dioxide external gel different from the above, that is, used for the preparation of a carbon dioxide external gel in which carbon dioxide is dissolved in a substantially non-bubble state in the gel, and a weak acid, Viscosity comprising, as essential components, a granular material (A) containing a calcium ion scavenger as an essential component, calcium carbonate mixed with the granular material (A), a gelling agent gelled by calcium ions, and water. A composition for preparing a gel for external use of carbon dioxide characterized by comprising the product (B) has been proposed (Patent Document 2).
しかしながら、特許文献１に記載の二酸化炭素外用剤調製用組成物により調製された二酸化炭素外用剤は、上述した問題点以外にも、外用剤そのものがべたつくために、使用時に外用剤が毛髪に付着したりして使用者に不快感を与えたりすることや、あるいはハイドロゲル化していないために使用後には皮膚粘膜から剥離除去しにくいという問題点があった。 However, the carbon dioxide external preparation prepared by the composition for preparing a carbon dioxide external preparation described in Patent Document 1 has a stickiness to the external preparation in addition to the above-mentioned problems, so that the external preparation adheres to the hair during use. In other words, there is a problem that the user is uncomfortable, or that it is not hydrogelated and therefore it is difficult to peel and remove from the skin mucous membrane after use.
また特許文献２に記載の二酸化炭素外用ゲル調製用組成物あるいはそれから調製された二酸化炭素外用ゲルの場合には、二酸化炭素の発生とハイドロゲル化が同時に起こるため、発生した二酸化炭素がゲル中に気泡化したり、あるいは大気中に散逸したりする問題点や、さらには原料の種類、配合割合などによってはゲル化が完了する前に二酸化炭素の発生が完了してしまうなどの問題点はなく、特許文献１に記載の外用剤よりも、より強い美容もしくは医療効果が得られ、また使用後の剥離除去も容易であるものの、必要に応じて任意の時間に硬化させ剥離除去することができないという問題点があった。 In addition, in the case of the composition for preparing carbon dioxide external gel described in Patent Document 2 or the gel for external use of carbon dioxide prepared therefrom, the generation of carbon dioxide and hydrogelation occur at the same time. There are no problems such as bubbling or dissipating into the atmosphere, and there are no problems such as the generation of carbon dioxide being completed before gelation is completed depending on the type of raw material and the mixing ratio, Although stronger cosmetic or medical effect is obtained than the external preparation described in Patent Document 1, and it is easy to peel and remove after use, it cannot be cured and peeled off at any time if necessary. There was a problem.
本発明の目的は、二価陽イオンによって弾性体を形成する高分子を必須成分とする二酸化炭素外用剤の使用後に、該二酸化炭素外用剤の表面に塗布して硬化させ、該二酸化炭素外用剤の剥離除去を容易とすることを特徴とする二酸化炭素外用剤の剥離除去方法及びそれに用いる二価陽イオン含有水性溶液を提供することにある。 An object of the present invention is to use a carbon dioxide external preparation containing a polymer that forms an elastic body with a divalent cation as an essential component, and then apply and cure the carbon dioxide external preparation on the surface of the carbon dioxide external preparation. An object of the present invention is to provide a method for exfoliating and removing a carbon dioxide external preparation characterized by facilitating exfoliation and removal of a divalent cation-containing aqueous solution.
本発明者は、種々検討した結果、二価陽イオンによって弾性体を形成する高分子を必須成分とする二酸化炭素外用剤の使用後に、該二酸化炭素外用剤の表面に二価陽イオン含有水性溶液を塗布して硬化させることにより二酸化炭素外用剤の剥離除去を容易とさせることを特徴とする二酸化炭素外用剤の剥離除去方法が、上記課題を解決することを見出し、本発明を完成させた。 As a result of various studies, the present inventor has found that a divalent cation-containing aqueous solution is formed on the surface of the carbon dioxide external preparation after the use of the carbon dioxide external preparation containing a polymer that forms an elastic body with divalent cations as an essential component. The present invention has been completed by finding that a method for exfoliating and removing a carbon dioxide external preparation that makes it easy to exfoliate and remove the carbon dioxide external preparation by applying and curing the above.
また本発明は、上記二価陽イオン含有水性溶液に、さらに起泡剤及び泡沫安定化剤が添加されている該二酸化炭素外用剤の剥離除去方法である。 Moreover, this invention is the peeling removal method of this carbon dioxide external preparation by which the foaming agent and the foam stabilizer are further added to the said bivalent cation containing aqueous solution.
また本発明は、二価陽イオンによって弾性体を形成する高分子が、アルギン酸又はその一価の塩である上記二酸化炭素外用剤の剥離除去方法である。 The present invention also provides the method for exfoliating and removing the carbon dioxide external preparation, wherein the polymer that forms an elastic body with divalent cations is alginic acid or a monovalent salt thereof.
また本発明は、二価陽イオン含有水性溶液が、カルシウム塩含有水性溶液である二酸化炭素外用剤の剥離除去方法である。 Moreover, this invention is a peeling removal method of the carbon dioxide external preparation whose divalent cation containing aqueous solution is a calcium salt containing aqueous solution.
さらに本発明は、上記二酸化炭素外用剤の剥離除去方法に用いる二酸化炭素外用剤剥離除去用二価陽イオン含有水性溶液である。 Furthermore, the present invention is a divalent cation-containing aqueous solution for removing and removing carbon dioxide external preparation used in the method for removing and removing carbon dioxide external preparation.
本発明の、二価陽イオンによって弾性体を形成する高分子を必須成分とする二酸化炭素外用剤の使用後に、該二酸化炭素外用剤の表面に塗布して硬化させることにより該二酸化炭素外用剤の剥離除去を容易とすることを特徴とする二酸化炭素外用剤の剥離除去方法を用いることにより、二酸化炭素外用剤塗布後の任意の時間に該二酸化炭素外用剤を硬化させ皮膚粘膜からの剥離除去が容易に達成できる。従って、上記に用いる本発明の二酸化炭素外用剤剥離除去用二価陽イオン含有水性溶液は、二価陽イオンによって弾性体を形成する高分子を必須成分とする二酸化炭素外用剤の剥離除去に有用である。 After the use of the carbon dioxide external preparation of the present invention, which comprises a polymer that forms an elastic body with divalent cations as an essential component, the carbon dioxide external preparation is coated and cured on the surface of the carbon dioxide external preparation. By using the carbon dioxide external agent exfoliation and removal method characterized by facilitating exfoliation and removal, the carbon dioxide external agent can be cured at any time after the carbon dioxide external agent application, and the exfoliation and removal from the skin mucosa can be achieved. Can be easily achieved. Therefore, the divalent cation-containing aqueous solution for removing and removing carbon dioxide external preparation of the present invention used above is useful for removing and removing carbon dioxide external preparation containing a polymer that forms an elastic body with divalent cations as an essential component. It is.
本発明でいう二酸化炭素外用剤とは、二価陽イオンによって弾性体を形成する高分子を必須成分とする二酸化炭素外用剤であれば特に限定されるものではなく、例えば、二価陽イオンとしてはカルシウムイオン、マグネシウムイオン等が挙げられ、弾性体を形成する高分子としてはアルギン酸又はその一価の塩が挙げられる。 The carbon dioxide external preparation referred to in the present invention is not particularly limited as long as it is a carbon dioxide external preparation containing a polymer that forms an elastic body with divalent cations as an essential component. Includes calcium ions, magnesium ions and the like, and examples of the polymer forming the elastic body include alginic acid or a monovalent salt thereof.
上記の中でも、カルシウムイオンとアルギン酸ナトリウムがそれぞれより好ましい。 Among the above, calcium ions and sodium alginate are more preferable.
二酸化炭素外用剤は、例えば、国際公開ＷＯ２００２／０８０９４１号特許公報に記載の粒状物（Ａ）と粘性組成物（Ｂ）からなる二酸化炭素外用剤調製用組成物を用いて調製される二酸化炭素外用剤のうち、二価陽イオンによって弾性体を形成する高分子を必須成分とする二酸化炭素外用剤を挙げることができる。その場合、例えば、二価陽イオンによって弾性体を形成する高分子は、増粘剤の一つとして粘性組成物中に配合される。 The carbon dioxide external preparation is, for example, a carbon dioxide external preparation prepared using a composition for preparing a carbon dioxide external preparation comprising a granular material (A) and a viscous composition (B) described in International Publication WO2002 / 080941. Among the agents, mention may be made of a carbon dioxide external preparation containing a polymer that forms an elastic body with divalent cations as an essential component. In this case, for example, a polymer that forms an elastic body with divalent cations is blended in the viscous composition as one of thickeners.
本発明の、二酸化炭素外用剤の剥離除去方法は、上記のようにして調製した二酸化炭素外用剤を皮膚粘膜に塗布した後、使用後に、例えば後記する、ポンプフォーマーに充填された二価陽イオン含有水性溶液を該二酸化炭素外用剤の表面に塗布して、それを硬化させることにより容易に該二酸化炭素外用剤が剥離除去可能となる方法である。 The method for exfoliating and removing the carbon dioxide external preparation of the present invention comprises applying the carbon dioxide external preparation prepared as described above to the skin mucous membrane, and then, after use, for example, a divalent positive electrode filled in a pump former described later. In this method, the carbon dioxide external preparation can be easily peeled and removed by applying an ion-containing aqueous solution to the surface of the carbon dioxide external preparation and curing it.
本発明の、二酸化炭素外用剤剥離除去用二価陽イオン含有水性溶液は、二価陽イオンが含有された水性溶液であれば特に限定されるものではないが、例えば、カルシウムイオン、マグネシウムイオンを含有する水性溶液等が挙げられる。また本発明で言う水性溶液とは、溶媒として医薬品や化粧品の製造で通常用いる蒸留水、イオン交換水、膜濾過水などが適宜使用され、該水の他にアルコールなどの有機溶媒や多価アルコール等、その他の溶媒と混合された液も包含される。 The divalent cation-containing aqueous solution for removing and removing carbon dioxide external preparation of the present invention is not particularly limited as long as it is an aqueous solution containing divalent cations. For example, calcium ions and magnesium ions are used. Examples thereof include an aqueous solution. The aqueous solution referred to in the present invention is appropriately used distilled water, ion-exchanged water, membrane filtered water, etc., which are usually used in the manufacture of pharmaceuticals and cosmetics, as well as organic solvents such as alcohols and polyhydric alcohols. Etc., liquids mixed with other solvents are also included.
上記二価陽イオン源となる物質としては、水に溶解したとき、二価陽イオンを発生するものであれば特に限定されるものではなく、例えば、二価陽イオンがカルシウムイオンの場合には、塩化カルシウム、グルコン酸カルシウム、乳酸カルシウムなどの水溶性が高いものが好適に用いられる。また、グリセロリン酸カルシウムなどの、酸性で水溶性の増加する二価陽イオンは、酸と併用して用いられる。これらの中でもカルシウムのイオン化率が高い塩化カルシウムがより好ましい。 The substance serving as the divalent cation source is not particularly limited as long as it generates a divalent cation when dissolved in water. For example, when the divalent cation is a calcium ion, Those having high water solubility such as calcium chloride, calcium gluconate and calcium lactate are preferably used. Further, divalent cations that increase in acidity and water solubility, such as calcium glycerophosphate, are used in combination with an acid. Among these, calcium chloride having a high calcium ionization rate is more preferable.
本発明に用いる二酸化炭素外用剤剥離除去用二価陽イオン含有水性溶液は、液をそのまま塗布する場合や、霧状にしてスプレーとして用いることも可能であるが、これらは液が必要部位以外の部位に付着したり、目や口などに入ったりしやすいために、例えば起泡剤や泡沫安定化剤などとともにポンプフォーマーに充填され、使用時に泡状になるものが、上記のような問題がないこと、また泡状であるために少量で広範囲に塗布できること、などから好適に用いられる。 The divalent cation-containing aqueous solution for exfoliation and removal of carbon dioxide external agent used in the present invention can be applied as it is or sprayed in the form of a mist, but these are other than the necessary parts of the liquid. The above problem is that the foam former is filled with a foaming agent, foam stabilizer, etc. and becomes foamy when used because it easily adheres to the site or enters the eyes or mouth. It is preferably used because it is free of foam and can be applied over a wide range with a small amount because it is foamy.
前記起泡剤としては、起泡剤と二価陽イオンを水や水性溶液に溶解したときに遊離カルシウムイオンが形成されるものであれば特に限定されるものではなく、例えば、化粧品や医薬品に使用される非イオン性界面活性剤、両性界面活性剤あるいはカチオン性界面活性剤の１種又は２種以上が用いられる。それらの中でも両性界面活性剤であるアルキルアミドプロピルジメチルアミノ酢酸ベタイン（例えば、カプリルカプラミドプロピルベタイン）、アルキルジメチルアミノ酢酸ベタイン、アルキルジメチル硫酸ベタイン（例えば、ラウリルジメチル硫酸ベタイン）や非イオン性界面活性剤であるポリオキシエチレンアルキルエーテル、ポリアルコール脂肪酸エステル（例えば、デカグリセリルモノイソステアレート）、脂肪酸アルカノールアミド（例えば、ヤシ油脂肪酸ジエタノールアミド）、天然系界面活性剤であるサポニンが好適に用いられ、より好ましくはカプリルカプラミドプロピルベタイン、ヤシ油脂肪酸ジエタノールアミド、サポニンであり、さらに好ましくはカプリルカプラミドプロピルベタインである。 The foaming agent is not particularly limited as long as free calcium ions are formed when the foaming agent and a divalent cation are dissolved in water or an aqueous solution. One kind or two or more kinds of nonionic surfactants, amphoteric surfactants or cationic surfactants to be used are used. Among them, amphoteric surfactants such as alkylamidopropyldimethylaminoacetic acid betaine (for example, caprylcapramidopropylbetaine), alkyldimethylaminoacetic acid betaine, alkyldimethylsulfate betaine (for example, lauryldimethylsulfate betaine) and nonionic surfactant Polyoxyethylene alkyl ethers that are agents, polyalcohol fatty acid esters (for example, decaglyceryl monoisostearate), fatty acid alkanolamides (for example, coconut oil fatty acid diethanolamide), and saponins that are natural surfactants are preferably used. More preferred are capryl capramidopropyl betaine, coconut oil fatty acid diethanolamide, and saponin, and further preferred is capryl capramidopropyl betaine.
前記泡沫安定化剤としては、泡沫を安定化させ得るものであれば特に限定されるものではないが、例えばゼラチン、カラギーナン、ローカストビーンガム、キサンタンガム、アラビアガム及びヒアルロン酸ナトリウムが好適に用いられ、より好ましくはゼラチンである。 The foam stabilizer is not particularly limited as long as it can stabilize the foam.For example, gelatin, carrageenan, locust bean gum, xanthan gum, gum arabic and sodium hyaluronate are preferably used. More preferred is gelatin.
本発明の、二酸化炭素外用剤剥離除去用二価陽イオン含有水性溶液には、上記成分以外にも、必要に応じて防腐剤や香料などを添加することができる。 In addition to the above components, a preservative, a fragrance, and the like can be added to the divalent cation-containing aqueous solution for removing and removing a carbon dioxide external preparation according to the present invention.
上記防腐剤としては、例えば、メチルパラベン、エチルパラベン、プロピルパラベンを挙げることができる。 Examples of the preservative include methyl paraben, ethyl paraben, and propyl paraben.
上記香料としては、例えば、天然香料であるバラ油、ジャスミン油、ペパーミント油、ベルガモット油、ラベンダー油、ムスク油などが、また合成香料としてリモネン、シトラール、リナロール、メントールなどが、また天然抽出液としてローズマリーエキス、カモミラエキス、セージエキス、ラベンダーエキスなどを挙げることができる。 Examples of the fragrances include natural fragrances such as rose oil, jasmine oil, peppermint oil, bergamot oil, lavender oil, musk oil, and synthetic fragrances such as limonene, citral, linalool, menthol, and natural extracts. Examples include rosemary extract, chamomile extract, sage extract, and lavender extract.
二価陽イオンによって弾性体を形成する高分子の配合量としては、例えば該高分子を粘性組成物に配合する場合には、粘性組成物全量に対して０．５〜２０重量％が好ましく、より好ましくは１〜１０重量％、さらに好ましくは２〜５重量％である。 As a blending amount of the polymer that forms an elastic body with divalent cations, for example, when blending the polymer in the viscous composition, 0.5 to 20% by weight is preferable with respect to the total amount of the viscous composition, More preferably, it is 1-10 weight%, More preferably, it is 2-5 weight%.
二価陽イオン源となる物質の配合量としては、水性溶液全量に対して５〜３０重量％が好ましい。 As a compounding quantity of the substance used as a divalent cation source, 5 to 30 weight% is preferable with respect to the aqueous solution whole quantity.
起泡剤の配合量は、水性溶液全量に対して１〜１０重量％が好ましく、より好ましくは１〜５重量％である。 The blending amount of the foaming agent is preferably 1 to 10% by weight, more preferably 1 to 5% by weight, based on the total amount of the aqueous solution.
泡沫安定化剤の配合量は、水性溶液全量に対して０．５〜５重量％が好ましく、より好ましくは１〜３重量％である。 The blending amount of the foam stabilizer is preferably 0.5 to 5% by weight, more preferably 1 to 3% by weight, based on the total amount of the aqueous solution.
防腐剤の配合量は、水性溶液全量に対して０．０５〜１重量％が好ましい。 The compounding amount of the preservative is preferably 0.05 to 1% by weight with respect to the total amount of the aqueous solution.
香料の配合量は、水性溶液全量に対して０．０１〜２重量％が好ましく、より好ましくは０．１〜１重量％である。 The blending amount of the fragrance is preferably 0.01 to 2% by weight, more preferably 0.1 to 1% by weight, based on the total amount of the aqueous solution.
本発明の二酸化炭素外用剤の剥離除去方法を美容方法として用いる場合には、二酸化炭素を吸収させた後、直ちに本発明の二価陽イオン含有水性溶液を用いて剥離除去すればよい。 When using the method for exfoliating and removing the carbon dioxide external preparation of the present invention as a cosmetic method, the carbon dioxide is absorbed and then immediately removed using the divalent cation-containing aqueous solution of the present invention.
一方、本発明の二酸化炭素外用剤の剥離除去方法を医療方法として用いる場合には、二酸化炭素を吸収させた後、直ちに本発明の二価陽イオン含有水性溶液を用いて硬化させた後、必要に応じて数時間から数日間そのままの状況で創傷被覆材として保持し、その後該二酸化炭素外用剤を剥離除去することも可能である。 On the other hand, when the method for exfoliating and removing carbon dioxide external preparation of the present invention is used as a medical method, it is necessary to absorb carbon dioxide and immediately harden it using the divalent cation-containing aqueous solution of the present invention. Depending on the situation, it is possible to hold the wound dressing as it is for several hours to several days, and then peel off and remove the carbon dioxide external preparation.
上記の美容方法又は医療方法のいずれの場合にも、本発明の、二酸化炭素外用剤剥離除去用二価陽イオン含有水性溶液の１回当たりの使用量は特に限定されるものではなく、例えば、二価陽イオン含有水性溶液を充填したポンプフォーマーより適宜必要な量を泡状で取り出し、それを、使用後の二酸化炭素外用剤の表面に塗布して硬化させて剥離除去を容易とするための量を使用すればよい。 In any case of the above cosmetic method or medical method, the amount of the divalent cation-containing aqueous solution for removing and removing the carbon dioxide external preparation of the present invention is not particularly limited, for example, To remove the necessary amount in the form of foam from a pump former filled with a divalent cation-containing aqueous solution, and apply it to the surface of the carbon dioxide external preparation after use to cure it for easy peeling and removal. Can be used.
以下に、試験例を挙げて本発明の効果を具体的に説明する。
試験例１（剥離除去比較試験）
１．試験方法
製造例１に記載の粒状物（１）０．６ｇと粘性組成物（１）１２．５ｇをプラスチック容器中でスパチュラを用いて均一に攪拌混合し、比較試験用二酸化炭素外用剤を調製した。５人の評価パネリストが各試験用二酸化炭素外用剤を左右の顔半面に塗布し、３０分間そのまま静置してパックを行った。３０分後、右側の顔半面に、泡状の実施例１の二価陽イオン（塩化カルシウム）含有水性溶液約１ｇを、スパチュラを用いて前記二酸化炭素外用剤の表面に万遍なく塗布した。その後直ちに、左右の顔半面ずつの二酸化炭素外用剤を手で剥離除去し、剥離除去のしやすさを表１に示した４段階の評価基準で各自に評価してもらった。
The effects of the present invention will be specifically described below with reference to test examples.
Test Example 1 (Peeling removal comparison test)
1. Test method 0.6 g of the granular material (1) described in Production Example 1 and 12.5 g of the viscous composition (1) are uniformly stirred and mixed in a plastic container using a spatula to prepare a carbon dioxide external preparation for comparison test. did. Five evaluation panelists applied each test carbon dioxide external preparation to the left and right face halves, and left it for 30 minutes to pack. After 30 minutes, about 1 g of a foam-like aqueous solution containing the divalent cation (calcium chloride) of Example 1 was applied to the right half of the face on the surface of the carbon dioxide external preparation using a spatula. Immediately thereafter, the carbon dioxide topical agent for each half of the left and right faces was peeled and removed by hand, and the ease of peeling and removal was evaluated by each of the four evaluation criteria shown in Table 1.
２．試験結果
結果を表２に示した。表２から明らかなように、本発明の二価陽イオン含有水性溶液を使用した場合、非常に剥離除去が容易なことが判明した。
2. Test results The results are shown in Table 2. As is apparent from Table 2, it was found that when the divalent cation-containing aqueous solution of the present invention was used, peeling and removal were very easy.
試験例２（経時硬化・剥離除去試験）
試験例１と同様に、製造例１に記載の粒状物（１）０．６ｇと粘性組成物（１）１２．５ｇをプラスチック容器中でスパチュラを用いて均一に攪拌混合し、比較試験用二酸化炭素外用剤を調製した。５人の評価パネリストが各試験用二酸化炭素外用剤を左右の顔半面に塗布し、右側の顔半面には２分後に、左側の顔半面には１０分後に、泡状の実施例１の二価陽イオン含有水性溶液約１ｇを、スパチュラを用いて前記二酸化炭素外用剤の表面に万遍なく塗布した。その後直ちに、左右の顔半面ずつの二酸化炭素外用剤を手で剥離除去し、剥離除去のしやすさを表１に示した４段階の評価基準で各自に評価してもらった。同様に再度上記と同じ二酸化炭素外用剤を左右の顔半面に塗布し、さらに２０分後、３０分後にそれぞれ右側の顔半面、左側の顔半面に泡状の実施例１の二価陽イオン含有水性溶液約１ｇを、スパチュラを用いて前記二酸化炭素外用剤の表面に万遍なく塗布した。２０分後、３０分後に左右顔半面の二酸化炭素外用剤の剥離除去のしやすさを表１に示した４段階の評価基準で各自に評価してもらった。
２．試験結果
結果を表３に示した。表３から明らかなように、本発明の二価陽イオン含有水性溶液を使用した場合、任意の時間に剥離除去が容易なことが判明した。
Test Example 2 (Aging over time / Peeling removal test)
As in Test Example 1, 0.6 g of the granular material (1) described in Production Example 1 and 12.5 g of the viscous composition (1) were uniformly stirred and mixed in a plastic container using a spatula. A carbon external preparation was prepared. Five evaluation panelists applied each test carbon dioxide topical preparation on the left and right face half faces, 2 minutes on the right face half face, 10 minutes on the left face half face, and the foamy Example 1 2 About 1 g of a valent cation-containing aqueous solution was uniformly applied to the surface of the carbon dioxide external preparation using a spatula. Immediately thereafter, the carbon dioxide topical agent for each half of the left and right faces was peeled and removed by hand, and the ease of peeling and removal was evaluated by each of the four evaluation criteria shown in Table 1. Similarly, the same carbon dioxide external preparation as described above was applied again to the left and right face halves, and after 20 minutes and 30 minutes, the right-hand face half and the left-hand face half respectively contained foamy divalent cations of Example 1. About 1 g of the aqueous solution was uniformly applied to the surface of the carbon dioxide external preparation using a spatula. Twenty minutes later, 30 minutes later, each of the left and right face half-faces was evaluated for ease of exfoliation and removal of the carbon dioxide external preparation by the four-step evaluation criteria shown in Table 1.
2. Test results The results are shown in Table 3. As is apparent from Table 3, when the divalent cation-containing aqueous solution of the present invention was used, it was found that peeling removal was easy at an arbitrary time.
以下に、実施例、比較例及び製造例を挙げて本発明をさらに具体的に説明する。 Hereinafter, the present invention will be described more specifically with reference to Examples, Comparative Examples, and Production Examples.
実施例１（二価陽イオン含有水性溶液）
塩化カルシウム二水和物１０重量部、カプリルカプラミドプロピルベタイン２重量部、ゼラチン２重量部、メチルパラベン０．１重量部をビーカーに取り、それに精製水を加えて全量を１００重量部とした。次にそれを５０℃に加熱して１時間撹拌して水性溶液とし、その水性溶液を容量５０ｍｌのポンプフォーマーに充填して、実施例１の二価陽イオン含有水性溶液を得た。
Example 1 (Divalent cation-containing aqueous solution)
10 parts by weight of calcium chloride dihydrate, 2 parts by weight of caprylcapramidopropyl betaine, 2 parts by weight of gelatin and 0.1 part by weight of methylparaben were placed in a beaker, and purified water was added thereto to make a total amount of 100 parts by weight. Next, it was heated to 50 ° C. and stirred for 1 hour to obtain an aqueous solution, and the aqueous solution was charged into a pump former having a capacity of 50 ml to obtain a divalent cation-containing aqueous solution of Example 1.
実施例２（二酸化炭素外用剤の剥離除去方法）
下記製造例（１）に記載の粘性組成物（１）２５．０ｇをプラスチック容器に取り、粒状物（１）１．２ｇを添加してスパチュラで十分攪拌混合し、二酸化炭素外用剤（１）を調製した。それを女性被験者Ａの額、頬、顎の各部分にスパチュラを用いて厚さ約１ｍｍに塗布して二酸化炭素を皮膚粘膜より吸収させた。塗布３０分経過後、実施例１の二価陽イオン含有水性溶液を上記二酸化炭素外用剤の表面に塗布した。塗布直後に直ちに硬化したので、ハイドロゲル全体を剥離除去し、実施例２の剥離除去方法を実施した。
Example 2 (Method for peeling and removing carbon dioxide external preparation)
Take 25.0 g of the viscous composition (1) described in the following Production Example (1) in a plastic container, add 1.2 g of the granular material (1), mix thoroughly with a spatula, and prepare the carbon dioxide external preparation (1). Was prepared. This was applied to each part of the forehead, cheek, and chin of female subject A to a thickness of about 1 mm using a spatula to absorb carbon dioxide from the skin mucosa. After 30 minutes of application, the divalent cation-containing aqueous solution of Example 1 was applied to the surface of the carbon dioxide external preparation. Since it hardened immediately after application | coating, the hydrogel whole was peeled and removed, and the peeling removal method of Example 2 was implemented.
比較例１
実施例１と同様に、下記製造例（１）に記載の粘性組成物（１）２５．０ｇをプラスチック容器に取り、粒状物（１）１．２ｇを添加してスパチュラで十分攪拌混合し、二酸化炭素外用剤（１）を調製した。それを女性被験者Ａの額、頬、顎の各部分にスパチュラを用いて厚さ約１ｍｍに塗布して二酸化炭素を皮膚粘膜より吸収させた。塗布３０分経過後、実施例１の二価陽イオン含有水性溶液を上記二酸化炭素外用剤の表面に塗布することなく、該二酸化炭素外用剤を剥離除去し、比較例１の剥離除去方法を実施した。
Comparative Example 1
In the same manner as in Example 1, 25.0 g of the viscous composition (1) described in the following Production Example (1) is taken in a plastic container, 1.2 g of the granular material (1) is added, and sufficiently stirred and mixed with a spatula. A carbon dioxide external preparation (1) was prepared. This was applied to each part of the forehead, cheek, and chin of female subject A to a thickness of about 1 mm using a spatula to absorb carbon dioxide from the skin mucosa. After 30 minutes of application, the carbon dioxide external preparation was peeled and removed without applying the divalent cation-containing aqueous solution of Example 1 to the surface of the carbon dioxide external preparation, and the peel removal method of Comparative Example 1 was carried out. did.
製造例１
〔粒状物（１）の製造〕
リンゴ酸２０重量部、バレイショデンプン１０重量部、加工澱粉７重量部、乳糖６０重量部、デキストリン３重量部を用い、水を溶媒として湿式押し出し造粒法により長さ約４ｍｍ、直径約１ｍｍの柱状の粒状物（１）を製造した。
〔粘性組成物（１）〕
精製水９１．５重量部に炭酸水素ナトリウム４．０重量部を溶かし、６０℃まで徐々に加温しながら増粘剤としてアルギン酸ナトリウム１．５重量部、カルボキシメチルセルロースナトリウム３．０重量部を徐々に加えて攪拌しながら溶かし、溶解後一晩放置して、室温まで冷まして粘性組成物（１）を製造した。
〔二酸化炭素外用剤調製用組成物（１）〕
上記粒状物（１）と粘性組成物（１）を組み合わせて製造例１の二酸化炭素外用剤調製用組成物（１）とした。
Production Example 1
[Production of granular material (1)]
20 parts by weight of malic acid, 10 parts by weight of potato starch, 7 parts by weight of modified starch, 60 parts by weight of lactose, 3 parts by weight of dextrin, and a columnar shape having a length of about 4 mm and a diameter of about 1 mm by wet extrusion granulation using water as a solvent The granular material (1) was produced.
[Viscous composition (1)]
Dissolve 4.0 parts by weight of sodium hydrogen carbonate in 91.5 parts by weight of purified water, and gradually heat 1.5 parts by weight of sodium alginate and 3.0 parts by weight of sodium carboxymethyl cellulose as a thickener while gradually heating to 60 ° C. In addition, the mixture was dissolved with stirring. After dissolution, the mixture was allowed to stand overnight and cooled to room temperature to produce a viscous composition (1).
[Composition for preparing carbon dioxide external preparation (1)]
The granular material (1) and the viscous composition (1) were combined to obtain a carbon dioxide external preparation preparation composition (1) of Production Example 1.
製造例２
〔粒状物（２）の製造〕
リンゴ酸２０重量部と乳糖６０重量部を、クエン酸３０重量部、乳糖５０重量部とする以外は、製造例１の粒状物（１）の製造と同様に調製し、粒状物（２）を製造した。
〔粘性組成物（２）の製造〕
精製水８８．５重量部に炭酸水素ナトリウム３．０重量部と、ソウハクヒエキス、オタネニンジンエキス、シソエキス、シコンエキス、ローズマリーエキスをそれぞれ０．１重量部、１，２−ペンタンジオール３．０重量部を溶かし、６０℃まで徐々に加温しながら増粘剤としてアルギン酸ナトリウム３．０重量部、カルボキシメチルセルロースナトリウム２．０重量部を徐々に加えて攪拌しながら溶かし、溶解後一晩放置して、室温まで冷まして粘性組成物（２）を製造した。
〔二酸化炭素外用剤調製用組成物（２）〕
上記粒状物（２）と粘性組成物（２）を組み合わせて二酸化炭素外用剤調製用組成物（２）とした。
Production Example 2
[Production of granular material (2)]
A granular material (2) is prepared in the same manner as in the production of the granular material (1) of Production Example 1 except that 20 parts by weight of malic acid and 60 parts by weight of lactose are changed to 30 parts by weight of citric acid and 50 parts by weight of lactose. Manufactured.
[Production of viscous composition (2)]
88.5 parts by weight of purified water, 3.0 parts by weight of sodium bicarbonate, 0.1 parts by weight of Sakuhak extract, ginseng extract, perilla extract, sicon extract and rosemary extract, respectively, 3.0 parts by weight of 1,2-pentanediol , And gradually warmed up to 60 ° C. while gradually adding 3.0 parts by weight of sodium alginate and 2.0 parts by weight of sodium carboxymethylcellulose as a thickener and dissolved with stirring. The viscous composition (2) was produced by cooling to room temperature.
[Composition for preparing carbon dioxide external preparation (2)]
The granular material (2) and the viscous composition (2) were combined to obtain a carbon dioxide external preparation preparation composition (2).
Claims (4)
ａ）起泡剤が、アルキルアミドプロピルジメチルアミノ酢酸ベタイン、アルキルジメチルアミノ酢酸ベタイン、アルキルジメチル硫酸ベタイン、ポリオキシエチレンアルキルエーテル、ポリアルコール脂肪酸エステル、脂肪酸アルカノールアミド及びサポニンから選択される１種又は２種以上であり、
ｂ）泡沫安定化剤が、ゼラチン、カラギーナン、ローカストビーンガム、キサンタンガム、アラビアガム及びヒアルロン酸ナトリウムから選択される１種又は２種以上であり、
ｃ）カルシウム塩が、塩化カルシウム、グルコン酸カルシウム、乳酸カルシウム及び酸と併用したグリセロリン酸カルシウムから選択される１種又は２種以上であり、
ａ）起泡剤、ｂ）泡沫安定化剤、及びｃ）カルシウム塩の配合量が、水性溶液全量に対してそれぞれ１〜１０重量％、０．５〜５重量％、５〜３０重量％であって、
任意の時間に硬化させ剥離除去することができる、前記二酸化炭素外用剤の剥離除去方法。 After applying a carbon dioxide external preparation containing sodium alginate as an essential component to the skin or mucous membrane to absorb carbon dioxide percutaneously through the mucosa, a) a foaming agent, b) foam stability on the surface of the carbon dioxide external preparation An exfoliation and removal method for a carbon dioxide external preparation characterized in that an exfoliating agent and c) an aqueous solution containing a calcium salt is applied in the form of a foam and the carbon dioxide external preparation is cured to facilitate its exfoliation and removal. There,
a) One or two foaming agents selected from alkylamidopropyldimethylaminoacetic acid betaine, alkyldimethylaminoacetic acid betaine, alkyldimethylsulfuric acid betaine, polyoxyethylene alkyl ether, polyalcohol fatty acid ester, fatty acid alkanolamide and saponin More than seeds,
b) The foam stabilizer is one or more selected from gelatin, carrageenan, locust bean gum, xanthan gum, gum arabic and sodium hyaluronate,
c) The calcium salt is one or more selected from calcium chloride, calcium gluconate, calcium lactate and calcium glycerophosphate used in combination with an acid,
The blending amount of a) foaming agent, b) foam stabilizer, and c) calcium salt is 1 to 10% by weight, 0.5 to 5% by weight, and 5 to 30% by weight with respect to the total amount of the aqueous solution, respectively. There,
The method for exfoliating and removing the carbon dioxide external preparation, which can be cured and removed at any time.
ａ）起泡剤が、アルキルアミドプロピルジメチルアミノ酢酸ベタイン、アルキルジメチルアミノ酢酸ベタイン、アルキルジメチル硫酸ベタイン、ポリオキシエチレンアルキルエーテル、ポリアルコール脂肪酸エステル、脂肪酸アルカノールアミド及びサポニンから選択される１種又は２種以上であり、
ｂ）泡沫安定化剤が、ゼラチン、カラギーナン、ローカストビーンガム、キサンタンガム、アラビアガム及びヒアルロン酸ナトリウムから選択される１種又は２種以上であり、
ｃ）カルシウム塩が、塩化カルシウム、グルコン酸カルシウム、乳酸カルシウム及び酸と併用したグリセロリン酸カルシウムから選択される１種又は２種以上であり、
さらにａ）起泡剤、ｂ）泡沫安定化剤及びｃ）カルシウム塩の配合量が、水性溶液全量に対してそれぞれ１〜１０重量％、０．５〜５重量％および５〜３０重量％である前記の水性溶液。 A) Foaming agent, b) Foam stabilizer and c) Calcium salt for removing and removing carbon dioxide external preparation for use in the method for peeling and removing carbon dioxide external preparation according to any one of claims 1 to 3. an aqueous solution containing,
a) One or two foaming agents selected from alkylamidopropyldimethylaminoacetic acid betaine, alkyldimethylaminoacetic acid betaine, alkyldimethylsulfuric acid betaine, polyoxyethylene alkyl ether, polyalcohol fatty acid ester, fatty acid alkanolamide and saponin More than seeds,
b) The foam stabilizer is one or more selected from gelatin, carrageenan, locust bean gum, xanthan gum, gum arabic and sodium hyaluronate,
c) The calcium salt is one or more selected from calcium chloride, calcium gluconate, calcium lactate and calcium glycerophosphate used in combination with an acid,
Further, the blending amounts of a) foaming agent, b) foam stabilizer and c) calcium salt are 1 to 10% by weight, 0.5 to 5% by weight and 5 to 30% by weight, respectively, based on the total amount of the aqueous solution. An aqueous solution as described above.
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