CN106535864B

CN106535864B - Composition for producing carbon dioxide external preparation, method for producing same, carbon dioxide external preparation, and cosmetic mask

Info

Publication number: CN106535864B
Application number: CN201480080524.4A
Authority: CN
Inventors: 大和谷朱美; 更家勝; 西亮介
Original assignee: Ibtj Co ltd
Current assignee: Ibtj Co ltd
Priority date: 2014-07-11
Filing date: 2014-10-09
Publication date: 2020-06-23
Anticipated expiration: 2034-10-09
Also published as: KR101958158B1; WO2016006127A1; KR20180093136A; JP6080810B2; SG11201610558PA; KR20170030583A; HK1231368A1; CN106535864A; JP2016020309A

Abstract

The present invention addresses the problem of providing a novel composition for producing a carbon dioxide external preparation, which has good spreadability without the coating surface solidifying from immediately after mixing 2 or more preparations until application to the skin, which does not remain on the skin until the end of use and which gels to release, and which generates membrane-permeable carbon dioxide in an amount exceeding the amount of membrane-permeable carbon dioxide generated from a composition for producing a carbon dioxide external preparation containing components known to date during use. Another object of the present invention is to provide a carbon dioxide external preparation and a cosmetic mask obtained from the novel composition for producing a carbon dioxide external preparation. A composition for preparing a carbon dioxide external preparation comprises at least a magnesium salt, a water-soluble calcium salt, a gelling agent which gels with magnesium ions or calcium ions, a carbonate, a substance which generates an acid by hydrolysis, a polyhydric alcohol and water as essential components.

Description

Composition for producing carbon dioxide external preparation, method for producing same, carbon dioxide external preparation, and cosmetic mask

Technical Field

The present invention relates to a composition for preparing a carbon dioxide external preparation which is mixed when 2 or more preparations are used.

Background

For the purpose of cosmetic and medical effects, there is known a technique of mixing an alkaline composition containing a carbonate salt and an acidic composition such as a water-soluble acid in the presence of water to generate carbon dioxide (see patent document 1 and the like).

Further, it is known that a carbon dioxide preparation for external use having a stronger cosmetic and medical effect can be easily prepared by using, as essential components, a substance which generates an acid by hydrolysis, a carbonate, a thickener, water, a gelling agent which gels by calcium ions, and a water-insoluble or water-insoluble calcium salt, and thereby continuously absorbing carbon dioxide through the skin and the mucous membrane (see patent document 2 and the like).

The composition for producing a carbon dioxide preparation for external use is a substance which generates carbon dioxide by mixing and reacting 2 or more preparations.

In addition, when a composition for producing a carbon dioxide external preparation is used in a cosmetic mask preparation, it is also known that the composition for producing a carbon dioxide external preparation can be coagulated by adding a gelling agent gelled by calcium ions or a water-insoluble or water-insoluble calcium salt to the composition for producing a carbon dioxide external preparation.

However, there is a problem that the speed of gelation and/or the hardness of the gel for the composition for producing the carbon dioxide external preparation becomes inappropriate depending on the kind and the compounding ratio of the gelling agent and the water-insoluble or poorly water-soluble calcium salt. That is, if the gelation is too fast, there is a problem that the composition for preparing the carbon dioxide external preparation is poor in spreadability when applied to the skin or the like, and a sufficient amount of carbon dioxide cannot be generated. On the other hand, if the gelation is too slow, there is a problem that it is difficult to peel the composition for preparing the carbon dioxide external preparation from the skin surface by hand, and it is difficult to use the composition as a mask preparation.

Documents of the prior art

Patent document

Patent document 1: japanese patent No. 4248878

Patent document 2: japanese patent No. 4595058

Disclosure of Invention

Technical problem

The present invention addresses the problem of providing a novel composition for producing a carbon dioxide external preparation, which has good spreadability when applied to the skin or the like immediately after mixing 2 or more preparations, generates a greater amount of membrane-permeable carbon dioxide than that generated from a composition for producing a carbon dioxide external preparation containing components known to date, and coagulates over time. Further, another object of the present invention is to provide a carbon dioxide external preparation and a cosmetic mask obtained from the novel composition for producing a carbon dioxide external preparation.

Technical scheme

As a result of intensive studies on the above-mentioned situation, the present inventors have found a composition for producing a carbon dioxide external preparation, which comprises a magnesium salt, a water-soluble calcium salt, a gelling agent which gels with magnesium ions or calcium ions, a carbonate, a substance which generates an acid by hydrolysis, a polyol and water as essential components.

Effects of the invention

According to the present invention, there can be provided the following composition for preparing a carbon dioxide external preparation: when the composition for preparing the external preparation for carbon dioxide, which is divided into 2 or more kinds of preparations, is mixed and applied to the skin so that at least the carbonate and the substance that generates an acid by hydrolysis are blended separately, the composition for preparing the external preparation for carbon dioxide, which contains a magnesium salt, a water-soluble calcium salt, a gelling agent that gels by magnesium ion or calcium ion, a carbonate, a substance that generates an acid by hydrolysis, a polyhydric alcohol, and water, the application surface is solidified in a state where the composition for preparing the external preparation for carbon dioxide is not adhered to the hand touching the application surface from the time of mixing until the time of application, and the composition for preparing the external preparation for carbon dioxide is not left on the skin and gels to be peeled until the time of use. That is, it is possible to provide a composition for producing a carbon dioxide external preparation which has good spreadability when the composition for producing a carbon dioxide external preparation is applied to the skin or the like and which solidifies to such an extent that it can be peeled off by hand after the lapse of a use time.

Further, according to the composition for producing a carbon dioxide external preparation of the present invention, by containing a magnesium salt, a water-soluble calcium salt, a gelling agent that gels by magnesium ions or calcium ions, a carbonate, a substance that generates an acid by hydrolysis, a polyol and water, it is possible to produce membrane-permeable carbon dioxide in an amount exceeding the amount of membrane-permeable carbon dioxide produced from the composition for producing a carbon dioxide external preparation including the components known in patent document 2 and the like.

Drawings

Fig. 1 is a graph showing the change with time of the amount of carbon dioxide produced in the membrane permeability in example 1 and comparative example 3.

FIG. 2 is a graph showing the change of pH with time in example 1 and comparative example 3.

Detailed Description

The composition for producing a carbon dioxide external preparation of the present invention is used for producing a carbon dioxide external preparation mixed when 2 or more kinds of preparations are used, and contains at least a magnesium salt, a water-soluble calcium salt, a gelling agent that gels by magnesium ions or calcium ions, a carbonate, a substance that generates an acid by hydrolysis, a polyol, and water, and may further contain other components as needed.

The magnesium salt is not particularly limited as long as it has magnesium in its chemical structural formula and generates magnesium ions in water, and may be appropriately selected according to the purpose. Examples thereof include magnesium oxide, magnesium carbonate, magnesium sulfate, magnesium aluminum silicate, magnesium L-ascorbate-2-phosphate, magnesium silicate, magnesium stearate, magnesium hydroxide, magnesium acetate, magnesium malate, and magnesium citrate. These may be used alone in 1 kind, or may be used in combination with 2 or more kinds, and may also contain other essential components such as carbonate. Among them, magnesium carbonate and magnesium oxide are preferable, and magnesium carbonate containing a carbonate as an essential component of a composition for producing a carbon dioxide external preparation is more preferable.

The content of the magnesium salt with respect to the total amount of the composition for preparing the carbon dioxide external preparation is not particularly limited and may be appropriately selected according to the purpose. If the content exceeds 12 mass%, the time required for the application surface to start to set or the time required for the gel to set to such an extent that the gel does not remain on the skin when peeled off becomes too short. On the other hand, when the content is less than 0.3% by mass, the time required for the application surface to start to coagulate or the time required for the gel to solidify to such an extent that it does not remain on the skin when peeled off becomes excessively long, and therefore, the content is preferably 0.3% by mass or more and less than 12% by mass, and more preferably 0.5% by mass or more and 11% by mass or less.

The water-soluble calcium salt is not particularly limited as long as it has calcium in its chemical structural formula and is water-soluble, and generates calcium ions in water, and it can be appropriately selected according to the purpose. Examples thereof include calcium chloride and calcium lactate. These may be used alone in 1 kind, or may be used in combination of 2 or more kinds, and may contain other essential components. Among them, calcium salts which gel until the end of use to be peelable by hand are preferred for the compositions used for producing the carbon dioxide external preparations, and calcium chloride is more preferred from the viewpoint of solubility in water.

The content of the water-soluble calcium salt (excluding water in the water-soluble calcium salt) relative to the total amount of the composition for preparing the carbon dioxide external preparation is not particularly limited and may be appropriately selected according to the purpose. If the content is less than 0.003 mass%, the composition for producing a carbon dioxide external preparation does not sufficiently gel until the end of use and is less likely to peel off. On the other hand, if the content exceeds 0.05 mass%, the coated surface is easily solidified from the mixing to the coating, and therefore, it is preferably 0.003 mass% or more and 0.05 mass% or less, and more preferably 0.003 mass% or more and 0.03 mass% or less.

The gelling agent that gels by the magnesium ion or calcium ion is not particularly limited as long as it gels by the magnesium ion generated from the magnesium salt and/or the calcium ion generated from the water-soluble calcium salt, and the gelling agent can be appropriately selected according to the purpose. Examples thereof include carrageenan, xanthan gum, tara gum, and sodium alginate. These may be used alone in 1 kind, or may be used in combination of 2 or more kinds. Among them, sodium alginate and xanthan gum are preferable from the viewpoint of smoothness and ease of use in a coated state.

The content of the gelling agent gelled by magnesium ions or calcium ions with respect to the total amount of the composition for preparing the carbon dioxide external preparation is not particularly limited and may be appropriately selected according to the purpose. If the content is less than 1.0 mass%, the composition for producing a carbon dioxide external preparation is not sufficiently gelled, and it is difficult to obtain the effect as a skin external preparation. On the other hand, if it exceeds 7 mass%, the coating surface is likely to solidify in a state where the composition for producing the carbon dioxide external preparation is not attached to the hand touching the coating surface from the time of mixing until the time of coating, and therefore, it is preferably 1.0 mass% or more and 7 mass% or less, and more preferably 2 mass% or more and 5 mass% or less.

The carbonate is not particularly limited as long as it reacts with a substance that generates an acid by hydrolysis contained in the composition for preparing a carbon dioxide external preparation to generate carbon dioxide, and may be appropriately selected according to the purpose. Examples thereof include ammonium carbonate, ammonium hydrogencarbonate, potassium carbonate, potassium hydrogencarbonate, sodium carbonate, sodium hydrogencarbonate, magnesium carbonate, magnesium hydrogencarbonate, calcium carbonate, calcium hydrogencarbonate, barium carbonate and the like. These may be used alone in 1 kind, or 2 or more kinds may be used in combination, and other essential components such as magnesium salt and calcium salt may be used together. Among them, magnesium carbonate having both the generation of magnesium ions is more preferable.

The content of the carbonate with respect to the total amount of the composition for preparing the carbon dioxide external preparation is not particularly limited and may be appropriately selected according to purposes. If the content is less than 0.3 mass%, the amount of carbon dioxide generated is reduced, and it is difficult to sufficiently exhibit the effect as an external preparation obtained by generating carbon dioxide. On the other hand, if the content exceeds 12 mass%, the pH of the composition for producing a carbon dioxide external preparation becomes high, and the amount of carbon dioxide produced is likely to be present as carbonate ions and the membrane-permeable carbon dioxide production amount becomes small, and therefore, it is preferably 0.3 mass% or more and 12 mass% or less, and more preferably 0.5 mass% or more and 11 mass% or less.

The substance which generates an acid by hydrolysis is not particularly limited as long as it has 1 or more cyclic ester bonds in its molecular structure, and can be appropriately selected according to the purpose. Examples thereof include gluconolactone, pantolactone, D, L-or L-lactide (3, 6-dimethyl-1, 4-dioxane-2, 5-dione), D, L-or L-glycolide, phthalic anhydride, maleic anhydride, succinic anhydride, and the like. These may be used alone in 1 kind, or may be used in combination of 2 or more kinds. Among them, gluconolactone, D, L-lactide and the like are preferable, and gluconolactone is more preferable from the viewpoints of hydrolysis rate, rate of formation of acid which reacts with carbonate, and easiness of availability of the compound.

The content of the substance generating an acid by hydrolysis with respect to the total amount of the composition for preparing the carbon dioxide external preparation is not particularly limited and may be appropriately selected according to the purpose. If the content is less than 10 mass%, the amount of carbon dioxide generated by the reaction between the acid obtained by hydrolysis and the carbonate is reduced, and it is difficult to sufficiently exert the effect as an external preparation obtained by generating carbon dioxide. On the other hand, if the content exceeds 20 mass%, stirring and mixing with other components are difficult, and therefore, it is preferably 10 mass% or more and 20 mass% or less, and more preferably 13 mass% or more and 18 mass%.

The polyhydric alcohol is not particularly limited as long as it is an alcohol having 2 or more hydroxyl groups in its molecular structure, and may be appropriately selected according to the purpose. Examples thereof include ethylene glycol, propylene glycol, 1, 3-butanediol, polyethylene glycol, glycerol, 1, 8-octanediol, glycerol which is also a sugar alcohol, sorbitol, trehalose which is also a sugar, and the like. These may be used alone in 1 kind, or may be used in combination of 2 or more kinds. Among them, 1, 3-butanediol is preferable from the viewpoint of the effect of shortening the gelation time and moisture retention.

The content of the polyhydric alcohol with respect to the total amount of the composition for preparing the carbon dioxide external preparation is not particularly limited and may be appropriately selected according to the purpose. If the content is less than 5% by mass, the time for gelling the composition for producing a carbon dioxide external preparation after mixing 2 or more preparations becomes long, and the composition for producing a carbon dioxide external preparation cannot be gelled until the end of use until it can be peeled off by hand. On the other hand, if the content exceeds 25 mass%, the coated surface solidifies in a state where the composition for producing the carbon dioxide external preparation does not adhere to the hand touching the coated surface until the time of coating, and therefore, is preferably 5 mass% or more and 25 mass% or less, and more preferably 5 mass% or more and 20 mass% or less.

The water contained in the composition for preparing a carbon dioxide external preparation is not particularly limited as long as it is used for general cosmetics, pharmaceuticals, and the like, and may be appropriately selected according to the purpose. Examples thereof include distilled water, membrane-permeated water and deionized water. These may be used alone in 1 kind, or 2 or more kinds may be used in combination, and may be contained as an aqueous solution of other components such as an aqueous calcium chloride solution.

The content of the water with respect to the total amount of the composition for preparing the carbon dioxide external preparation is not particularly limited and may be appropriately selected according to purposes. The content is a total content of water contained in the water and other components such as the water-soluble calcium salt, and is prepared so that the total amount of the composition for preparing the carbon dioxide external preparation is 100 mass%. When the content is less than 55% by mass, the viscosity increases and the fluidity, flexibility, and solubility of other components are insufficient, so that the content is preferably 55% by mass or more.

The other components of the composition for preparing a carbon dioxide external preparation are not particularly limited as long as they are components used for cosmetics and skin external preparations, and may be appropriately selected according to the purpose. Examples of the surfactant include surfactants, pH adjusters, humectants, preservatives, antioxidants, perfumes, dispersants, ultraviolet absorbers, and pigments. These may be used alone in 1 kind, or may be used in combination of 2 or more kinds.

The form of use of the carbon dioxide external preparation is not particularly limited and may be appropriately selected according to the purpose. Examples thereof include a form in which 2 or more gel-like preparations are applied to the skin and mixed, a form in which 2 or more gel-like and granular preparations are applied to the skin and mixed, and a form in which granular preparations are dissolved in water and then the gel-like preparations are applied to the skin and mixed.

The method for evaluating whether or not the spreadability of the composition for preparing a carbon dioxide external preparation is good when applied to the skin or the like is not particularly limited as long as it can show whether or not the spreadability of the applied gel is good, and it can be selected according to the purpose. For example, the following methods can be mentioned: the "time until gel does not adhere to a finger when touching the application surface" from the start of application to the skin or the like after mixing 2 or more kinds of preparations was defined as "time until the application surface starts to set", and whether or not the spreadability was good was evaluated as the length of the "time until the application surface starts to set".

The method for evaluating the releasability of the composition for preparing the external preparation for carbon dioxide after application to the skin or the like is not particularly limited as long as it shows the releasability and the coagulability of the applied gel, and it can be selected according to the purpose. For example, the following methods may be mentioned: the "time from the start of application of 2 or more preparations to the skin or the like to the time when the gel does not remain on the skin at the time of peeling" is defined as "peeling time", and the length of this "peeling time" is compared with the use time to evaluate.

The method for evaluating the amount of carbon dioxide produced by membrane permeation of the composition for producing a carbon dioxide external preparation is not particularly limited as long as it is a method capable of measuring the amount of carbon dioxide permeating a membrane simulating a human skin environment, and may be appropriately selected according to the purpose. For example, a method of immersing a porous polymer membrane in a fat or oil to measure the amount of carbon dioxide permeating the membrane is mentioned. In order to be close to the human skin environment, it is particularly preferable to use a microporous membrane (microporosity film) (product of Sumitomo 3M Limited company, 3M microporosity film, pore diameter of 0.3 μ M or less) as the porous polymer membrane, and a method of using olive squalene (Kishimospecial squalene) (product of Kishimospecial lever co., ltd., product, plant squalene) as the oil or fat and using a carbon dioxide concentration meter (product of DKK-TOA corporation, model CGP-31) when measuring the amount of carbon dioxide permeated into the membrane.

The evaluation of the production amount of carbon dioxide permeable to the membrane of the composition for producing a carbon dioxide external preparation is specifically as follows: 1g of a gel obtained by stirring and mixing 2 or more kinds of agents was put into a carbon dioxide concentration meter-dedicated container, and a microporous membrane coated with 0.1g of olivine was placed thereon, and a carbon dioxide concentration meter detector was attached to the dedicated container. A predetermined amount of water was added using a syringe so that the space between the container and the detector was filled with water, after which the membrane-permeable carbon dioxide production was measured every 1 minute for 60 minutes and recorded.

As the method for evaluating the composition for preparing the carbon dioxide external preparation, the state of carbon dioxide generated from the composition for preparing the carbon dioxide external preparation can be confirmed by further measuring the pH of the composition for preparing the carbon dioxide external preparation when membrane-permeable carbon dioxide is generated.

The method for measuring the pH is not particularly limited as long as it is a method capable of measuring a change over time in the pH of the composition for producing a carbon dioxide external preparation, and may be appropriately selected according to the purpose. For example, there is a method of mixing 2 or more preparations with stirring and measuring the pH of a composition for producing a carbon dioxide external preparation with time using a daily waterproof pH meter (pHep 4 HI98127, manufactured by HANNA instruments).

Examples

The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to these examples at all.

(examples 1 to 9 and comparative examples 1 to 3)

Compositions for preparing carbon dioxide external preparations were prepared according to the compositions described in table 1. In the examples in which magnesium carbonate having both magnesium salt and carbonate was blended, compositions for producing carbon dioxide external preparations were prepared in the blending amounts of magnesium carbonate shown in the tables, but it can be said that magnesium salt and carbonate were blended in equal amounts under the blending conditions of the essential components such as in claims 4, 0034, and 0035.

The formulations divided into 2 kinds were stirred and mixed until they became uniform by visual observation immediately before use in accordance with the blending amounts shown in table 2.

[ Table 1]

The amounts (unit: mass%) of the components in examples and comparative examples

[ Table 2]

The amounts (unit: g) of the respective preparations in examples and comparative examples

The compositions for producing carbon dioxide external preparations obtained in examples 1 to 9 and comparative examples 1 to 3 were evaluated for good spreadability when applied to the skin or the like after mixing and easy peelability after use, by the evaluation methods shown below.

The time from the start of application of 2 or more formulations to the skin or the like to the time when the gel does not adhere to the fingers when the application surface is touched "was defined as" the time when the application surface starts to set ", and the" time when the application surface starts to set "was measured". Next, the time from the start of application of 2 or more formulations to the skin or the like to the time when the gel does not remain on the skin when peeled "was defined as" the peeling time ", and the" peeling time "was measured". then, the time when two times, the time when the application surface starts to set "and the" peeling time "were applied to the skin or the like after the 2 or more formulations were mixed was defined as" the time when the application surface starts to set ", and the time when the use time was defined as" the time when the application surface starts to set "and the" peeling time "were defined as" the good (◎) ", the case where both times were not applied within the predetermined time was evaluated as" the poor (△) ", the case where one was applied within the predetermined time but the other was not applied as" the normal (○) ", and the case where the non-use time was not applied was evaluated as the non-set (×).

In the examples and comparative examples described above, since the time for applying the composition for preparing a carbon dioxide external preparation to the skin or the like after mixing 2 or more preparations is within 5 minutes, the time for starting coagulation of the appropriate application surface is defined to be 5 to 10 minutes. In the examples and comparative examples described above, the composition for producing the carbon dioxide external preparation is used for 10 to 15 minutes, and therefore the appropriate peeling time is defined as 10 to 15 minutes.

Table 3 shows the evaluation results of whether the spreadability after mixing is good when applying to the skin or the like and the easy peelability after the end of use.

[ Table 3]

Evaluation results in examples and comparative examples

As is clear from table 3, in comparison with examples 1, 2 and 6 evaluated as good (◎), in comparative example 2 containing no water-soluble calcium salt, peeling was not possible after the end of use, and in examples 3 and 4 in which the amount of calcium chloride as a water-soluble calcium salt was large, the time for the coating surface to start setting was short and the spreadability at the time of coating was poor, and in comparative example 1 in which magnesium carbonate was changed to sodium hydrogencarbonate, neither the coating surface nor the inside was set, and in examples 7 and 8 in which the amount of magnesium carbonate added was further increased, both the time for the coating surface to start setting and the peeling time were short.

The composition for producing a carbon dioxide external preparation prepared in example 1 and comparative example 3 was evaluated for the amount of carbon dioxide produced in membrane permeability by the following method.

In the examples and comparative examples, 1g of a gel mixed with 2 kinds of agents described in table 2 was placed in a container dedicated to a carbon dioxide concentration meter, and a microporous membrane coated with 0.1g of olivine was covered from above, and a detector of the carbon dioxide concentration meter was attached to the container dedicated to the carbon dioxide concentration meter. A predetermined amount of water was added using a syringe so that the space between the container and the detector was filled with water, after which the amount of membrane-permeated carbon dioxide production was measured every 1 minute for 60 minutes and recorded.

The results of the membrane permeability carbon dioxide production test are shown in table 4.

[ Table 4]

Membrane permeable carbon dioxide production

(mg/L)

Time after mixing (minutes)	Example 1	Comparative example 3
			0	0	0
1	0	0
			2	10	10
3	20	20
			4	40	30
5	80	40
			6	110	100
7	150	140
			8	180	200
9	260	280
			10	370	360
11	520	460
			12	680	560
13	810	650
			14	930	770
15	1050	860
			16	1190	960
17	1330	1060
			18	1420	1140
19	1570	1230
			20	1670	1310
21	1740	1380
			22	1800	1450
23	1830	1510
			24	1870	1560
25	1900	1610
			26	1910	1650
27	1940	1680
			28	1970	1710
29	2000	1740
			30	2020	1770
31		1790
			32		1820
33		1840
			34		1860
35		1880
			36		1900
37		1920
			38		1940
39		1960
			40		1980
41		2000
			42		2020

Fig. 1 shows the changes with time of the amount of carbon dioxide produced in the membrane permeability of example 1 and comparative example 3, according to table 4.

As is clear from table 4 and fig. 1, when example 1 and comparative example 3 containing no magnesium ion and no water-soluble calcium salt were compared, the amount of carbon dioxide produced by membrane permeability after mixing until the expected usage time of example 1 was 15 minutes was about 1.2 times the amount of carbon dioxide produced by membrane permeability of comparative example 3.

The pH was measured by the following method. The 2 kinds of preparations described in example 1 and comparative example 3 were mixed with stirring, and the pH of the composition for preparing a carbon dioxide external preparation was measured with time using a daily waterproof pH meter (pHep 4 HI98127, manufactured by HANNA instruments).

The results of pH measurement are shown in table 5 and fig. 2.

[ Table 5] results of pH measurement

(pH)

As is clear from table 5 and fig. 2, in example 1, the pH immediately after mixing the preparation 2 was lowered to a pH of 4.0 to 6.5 at which carbon dioxide readily penetrates the membrane after 60 minutes had elapsed.

As is apparent from tables 3 to 5 and fig. 1 to 2, when the composition for preparing the carbon dioxide external preparation divided into 2 or more preparations is mixed and applied to the skin, the composition for preparing the carbon dioxide external preparation is not solidified in a state where the composition for preparing the carbon dioxide external preparation is not adhered to the hand touching the coating surface from the time of mixing to the time of application, and the composition for preparing the carbon dioxide external preparation is gelled to a state where it can be peeled off by hand until the time of use. That is, it is known that a composition for producing a carbon dioxide external preparation spreads well when applied to the skin or the like, and solidifies to a degree that can be peeled off by hand after the lapse of use time.

Further, it is known that by adding a magnesium salt, a water-soluble calcium salt, a gelling agent that gels with magnesium ions or calcium ions, a carbonate, a substance that generates an acid by hydrolysis, a polyol, and water to the composition for producing a carbon dioxide external preparation of the present invention, the pH is maintained at 4 to 6.5 from the start of use to the end of use, and membrane-permeable carbon dioxide is produced in an amount exceeding the amount of membrane-permeable carbon dioxide produced from the composition for producing a carbon dioxide external preparation containing the components known in patent document 2.

The above effect is based on several reasons: firstly, the effect is based on: by compounding a component that generates magnesium ions such as magnesium carbonate, ionic crosslinking of a gelling agent such as sodium alginate and xanthan gum is alleviated, as compared with the case where a component that generates calcium ions is compounded. The incorporation of magnesium ions helps to optimize the spreadability of the composition for preparing a carbon dioxide external preparation immediately after mixing or to solidify the whole gel. Furthermore, the effect is based on: by incorporating calcium chloride as a water-soluble calcium salt as a component generating calcium ions, ionic crosslinking of a gelling agent such as sodium alginate and/or xanthan gum is accelerated as compared with the case of incorporating calcium carbonate which is insoluble or poorly soluble in water. The incorporation of the water-soluble calcium ion helps to solidify from the coating surface of the composition for preparing the carbon dioxide external preparation immediately after mixing. The ionic crosslinking of the gelling agent can be accelerated by increasing the amount of butanediol as the polyol. The incorporation of butanediol helps to adjust the spreadability and peeling time of the composition for preparing a carbon dioxide external preparation immediately after mixing.

The above effects are based on the fact that the time for the coating surface to start to solidify and/or the peeling time are adjusted by appropriately mixing a component that generates magnesium ions such as magnesium carbonate and a water-soluble calcium salt, and that membrane-permeable carbon dioxide generated from the composition for producing a carbon dioxide external preparation can be discharged to the outside of the composition for producing a carbon dioxide external preparation. The incorporation of the magnesium ion-generating component and an appropriate amount of the water-soluble calcium salt enables the incorporation of a water-insoluble or water-sparingly-soluble calcium salt as the calcium ion-generating component in an appropriate amount and produces a greater amount of membrane-permeable carbon dioxide than the membrane-permeable carbon dioxide produced without the magnesium ion-generating component and from the composition for producing a carbon dioxide external preparation containing the heretofore known components.

Industrial applicability

The composition for producing a carbon dioxide external preparation of the present invention can be easily prepared by mixing 2 or more preparations, has good spreadability without solidifying the coating surface until the composition is applied to the skin immediately after mixing, can be peeled off without leaving on the skin until the end of the use period, and can continuously produce a sufficient amount of membrane-permeable carbon dioxide during the use period. Therefore, a cosmetic mask which can keep appropriate stimulation to the skin has good spreadability when applied, completely peels off when finished, has an effect as a so-called carbon dioxide mask, and can be suitably used not only for cosmetic masks but also for cosmetics such as exfoliating agents, non-pharmaceutical drugs such as external skin preparations and hair preparations, and any of pharmaceuticals and pet products.

The composition for producing a carbon dioxide external preparation of the present invention has characteristics that it cannot achieve good spreadability during application and can be peeled off at the end of use, which cannot be achieved in a gel-like so-called carbon dioxide mask film in the cosmetic field in particular. Therefore, although there have been some additional problems in the conventional treatment in which the gel that has not been completely solidified and has not been completely peeled off is wiped off with a towel at the end of use, and the towel that has been wiped off with the gel that has not been completely solidified is washed, the present invention can solve such additional problems.

Claims

1. A composition for producing a carbon dioxide external preparation,

at least magnesium carbonate, calcium chloride, a gelling agent gelled by magnesium ions or calcium ions, gluconolactone, butanediol and water as essential components,

the content of the magnesium carbonate is 0.8 to 2.8 mass% of the total amount of the composition for producing a carbon dioxide external preparation; the content of the calcium chloride is 0.004 mass% or more and 0.005 mass% or less with respect to the total amount of the composition for producing a carbon dioxide external preparation; a content of the gelling agent gelled by magnesium ions or calcium ions is 1.0 mass% or more and 7 mass% or less with respect to the total amount of the composition for producing a carbon dioxide external preparation; the content of the gluconolactone is 10 to 20 mass% based on the total amount of the composition for producing a carbon dioxide external preparation; the content of the butanediol is 5 to 20 mass% based on the total amount of the composition for producing the carbon dioxide external preparation.

2. The composition for the preparation of carbon dioxide external preparation according to claim 1,

magnesium carbonate and calcium chloride are blended so as to include a period during which the amount of carbon dioxide produced by membrane permeability exceeds the amount of carbon dioxide produced by membrane permeability when the composition for producing an external preparation for carbon dioxide, which is obtained by removing magnesium carbonate and changing calcium chloride to calcium carbonate, is mixed.

3. A method for producing the composition for the preparation of a carbon dioxide external preparation according to claim 1 or 2.

4. A carbon dioxide external preparation, which is prepared using the composition for preparing a carbon dioxide external preparation according to claim 1 or 2.

5. A cosmetic mask prepared using the composition for preparing a carbon dioxide external preparation according to claim 1 or 2.