WO2016006127A1 - Composition for preparing carbon dioxide formulation for external use, method for producing same, method for evaluating same, and carbon dioxide formulation for external use - Google Patents

Abstract

The present invention addresses the problem of providing a novel composition for preparing carbon dioxide formulation for external use, said composition being highly spreadable on the skin immediately after mixing two or more agents until applying to the skin while preventing the surface of the applied composition from beginning to solidify, being capable of gelling so that the composition can be separated from the skin without remaining on the skin at the end of the use, and, during use period, generating membrane permeable carbon dioxide in an amount greater than the amount of membrane permeable carbon dioxide generated by a conventional composition for preparing carbon dioxide formulation for external use that comprises known components. Also, the present invention addresses the problem of providing a carbon dioxide formulation for external use and a cosmetic pack that are obtained from the novel composition for preparing carbon dioxide formulation. The composition for preparing carbon dioxide formulation at least comprises, as essential components, a gelling agent that gels in the presence of a magnesium salt, a water-soluble calcium salt, magnesium ion or calcium ion, a carbonic acid salt, a substance that generates an acid when hydrolyzed, a polyhydric alcohol and water.

Description

Composition for preparing carbon dioxide external preparation, production method and evaluation method thereof, and carbon dioxide external preparation

This invention relates to the composition used for preparation of the carbon dioxide external preparation which mixes two or more agents at the time of use.

For the purpose of beauty and medical effects, a technology for generating a carbon dioxide gas by mixing a basic composition containing a carbonate and an acidic composition such as a water-soluble acid in the presence of water is known (Patent Literature). 1 etc.).
In addition, carbon dioxide can be sustained by using substances that hydrolyze to produce acids, carbonates, thickeners, water, gelling agents that gel with calcium ions, and water-insoluble or poorly water-soluble calcium salts as essential ingredients. It is also known that a carbon dioxide external preparation that can be percutaneously / transmucosally absorbed and has a stronger beauty and medical effect can be easily prepared (see Patent Document 2, etc.).

The composition for preparing a carbon dioxide external preparation is one in which two or more agents are mixed and reacted at the time of use to generate carbon dioxide.
Furthermore, when using a composition for preparing a carbon dioxide external preparation as a cosmetic pack, a gelling agent that gels with calcium ions and a water-insoluble or poorly water-soluble calcium salt are added to the composition for preparing a carbon dioxide external preparation. By doing so, it is known that the composition for preparing a carbon dioxide external preparation can be hardened.

However, there is a problem that the gelation speed and the gel hardness of the composition for preparing a carbon dioxide external preparation are not appropriate depending on the types and blending ratios of the gelling agent and the water-insoluble or poorly water-soluble calcium salt. That is, if the gelation is too fast, the composition for preparing a carbon dioxide external preparation has a problem that the elongation is poor when applied to the skin and the like, and sufficient carbon dioxide cannot be generated. On the other hand, if the gelation is too slow, the composition for preparing a carbon dioxide external preparation cannot be peeled cleanly from the skin surface by hand, and there is a problem that it is difficult to use as a pack agent.

Japanese Patent No. 4248878 Japanese Patent No. 4595058

The present invention has good elongation at the time of application to the skin or the like immediately after mixing of two or more agents, and from the amount of membrane-permeable carbon dioxide generated from a composition for preparing a carbon dioxide external preparation comprising conventionally known components. Another object of the present invention is to provide a novel composition for preparing a carbon dioxide external preparation that generates a large amount of membrane-permeable carbon dioxide and hardens by the time of use. Another object of the present invention is to provide a carbon dioxide external preparation and a cosmetic pack obtained from the novel composition for preparing carbon dioxide external preparation.

As a result of intensive studies in view of the above circumstances, the present inventors have found that magnesium salts, water-soluble calcium salts, gelling agents that gel with magnesium ions or calcium ions, carbonates, substances that are hydrolyzed to produce acids, many The composition for carbon dioxide external preparation preparation which used a monohydric alcohol and water as an essential component was discovered.

According to the present invention, by containing a magnesium salt, a water-soluble calcium salt, a gelling agent that gels with magnesium ions or calcium ions, a carbonate, a substance that is hydrolyzed to generate an acid, a polyhydric alcohol, and water, When the composition for preparing an external preparation for carbon dioxide divided into two or more agents is applied to the skin after mixing so that at least the carbonate and the substance that generates acid by hydrolysis are separately mixed, the mixture is applied from the mixing to the application. The coating surface does not harden in such a state that the composition for preparing a carbon dioxide external preparation does not adhere to the hand that has touched the coating surface before, and the composition for preparing a carbon dioxide external preparation does not touch the skin by the end of use. It is possible to provide a composition for preparing a carbon dioxide external preparation that gels so as not to be peeled off. That is, it is possible to provide a composition for preparing a carbon dioxide external preparation, which has good elongation when applied to the skin or the like, and is solidified to the extent that it can be peeled off by hand after the use time has elapsed.
Further, according to the composition for preparing a carbon dioxide external preparation of the present invention, a magnesium salt, a water-soluble calcium salt, a gelling agent that gels with magnesium ions or calcium ions, a carbonate, a substance that is hydrolyzed to generate an acid, By containing a polyhydric alcohol and water, the amount of membrane-permeable carbon dioxide exceeding the amount of membrane-permeable carbon dioxide generated from the composition for preparing a carbon dioxide external preparation comprising components known in Patent Document 2 and the like Can be generated.

The graph which shows the time-dependent change of the membrane-permeable carbon dioxide generation amount in Example 1 and Comparative Example 3. The graph which shows the time-dependent change of the pH value in Example 1 and Comparative Example 3.

The composition for preparing a carbon dioxide external preparation of the present invention is for preparing a carbon dioxide external preparation in which two or more agents are mixed at the time of use, and gels with a magnesium salt, a water-soluble calcium salt, magnesium ion or calcium ion. It contains at least a gelling agent, a carbonate, a substance that is hydrolyzed to generate an acid, a polyhydric alcohol, and water, and may further contain other components as necessary.

The magnesium salt is not particularly limited as long as it has magnesium in its chemical structural formula and generates magnesium ions in water, and can be appropriately selected depending on the purpose. For example, magnesium oxide, magnesium carbonate, magnesium sulfate, magnesium aluminate silicate, magnesium L-ascorbate-2-phosphate, magnesium silicate, magnesium stearate, magnesium hydroxide, magnesium acetate, magnesium malate, citric acid Examples include magnesium. These may be used individually by 1 type, may use 2 or more types together, and may serve as other essential components, such as carbonate. Among these, magnesium carbonate and magnesium oxide are preferable, and magnesium carbonate which also serves as a carbonate essential as a component of the composition for preparing carbon dioxide external preparation is more preferable.

The content of the magnesium salt with respect to the total amount of the composition for preparing carbon dioxide external preparation is not particularly limited and can be appropriately selected depending on the purpose. When the content exceeds 12% by mass, the time when the coated surface starts to harden and the time when the entire gel hardens to the extent that it can be peeled off without leaving the skin may be too short. On the other hand, when the content is less than 0.3% by mass, the time for the coating surface to start to solidify and the time for the gel to harden to the extent that it can be peeled without remaining on the skin become too long. % Is preferably less than 0.5%, more preferably 0.5% by mass or more and 11% by mass or less.

The water-soluble calcium salt is not particularly limited as long as it has calcium in its chemical structural formula and has water solubility and generates calcium ions in water, and can be appropriately selected depending on the purpose. Examples thereof include calcium chloride and calcium lactate. These may be used individually by 1 type, may use 2 or more types together, and may serve as another essential component. Among them, a calcium salt that gels so that the composition for preparing a carbon dioxide external preparation by hand can be peeled off by the end of use is preferable, and calcium chloride is more preferable in terms of solubility in water.

The content of the water-soluble calcium salt (excluding water in the water-soluble calcium salt) with respect to the total amount of the composition for preparing carbon dioxide external preparation is not particularly limited and can be appropriately selected depending on the purpose. When the content is less than 0.003% by mass, the composition for preparing a carbon dioxide external preparation is not sufficiently gelled by the end of use and is difficult to peel off. On the other hand, if the content exceeds 0.05% by mass, the coating surface tends to harden from mixing to coating, and therefore it is preferably 0.003% by mass or more and 0.05% by mass or less. More preferably, it is at least 0.03% by mass.

The gelling agent that gels with magnesium ions or calcium ions is not particularly limited as long as it gels with magnesium ions generated from the magnesium salt or calcium ions generated from the water-soluble calcium salt, and is appropriately selected depending on the purpose. can do. For example, carrageenan, xanthan gum, tara gum, sodium alginate and the like can be mentioned. These may be used alone or in combination of two or more. Among these, sodium alginate and xanthan gum are preferable from the viewpoint of smoothness in application state and ease of use.

The content of the gelling agent that gels with magnesium ions or calcium ions with respect to the total amount of the composition for preparing a carbon dioxide external preparation is not particularly limited and can be appropriately selected depending on the purpose. When the content is less than 1.0% by mass, the composition for preparing a carbon dioxide external preparation is not sufficiently gelled, and it is difficult to obtain an effect as a skin external preparation. On the other hand, if it exceeds 7% by mass, the coated surface tends to harden in a state where the composition for preparing a carbon dioxide external preparation does not adhere to the hand that touched the coated surface from mixing to coating. % To 7% by mass, more preferably 2% to 5% by mass.

The carbonate is not particularly limited as long as it is a carbonate that reacts with a substance that is hydrolyzed to generate an acid contained in the composition for preparing an external preparation for carbon dioxide, and is appropriately selected depending on the purpose. be able to. For example, ammonium carbonate, ammonium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, sodium carbonate, sodium hydrogen carbonate, magnesium carbonate, magnesium hydrogen carbonate, calcium carbonate, calcium hydrogen carbonate, barium carbonate and the like can be mentioned. These may be used individually by 1 type, may use 2 or more types together, and may serve as other essential components, such as a magnesium salt and a calcium salt. Of these, magnesium carbonate, which also serves to generate magnesium ions, is more preferable.

The content of the carbonate with respect to the total amount of the composition for preparing a carbon dioxide external preparation is not particularly limited and can be appropriately selected depending on the purpose. When the content is less than 0.3% by mass, the generated amount of carbon dioxide is reduced, and the effect as an external preparation obtained by the generation of carbon dioxide is not sufficiently exhibited. On the other hand, if the content exceeds 12% by mass, the pH of the composition for preparing a carbon dioxide external preparation is high, and the generated carbon dioxide tends to exist as carbonate ions, so the amount of generated membrane-permeable carbon dioxide decreases. It is preferably 0.3% by mass or more and 12% by mass or less, and more preferably 0.5% by mass or more and 11% by mass or less.

The substance that generates an acid by hydrolysis is not particularly limited as long as it has one or more cyclic ester bonds in its molecular structure, and can be appropriately selected depending on the purpose. For example, glucono delta lactone, pantolactone, D, L- or L-lactide (3,6-dimethyl-1,4-dioxane-2,5-dione), D, L- or L-glycolide, phthalic anhydride , Maleic anhydride, succinic anhydride and the like. These may be used alone or in combination of two or more. Of these, glucono delta lactone and D, L-lactide are preferable, and glucono delta lactone is more preferable from the viewpoints of hydrolysis rate, acid generation rate that reacts with carbonate, and availability of compounds.

The content of the substance that is hydrolyzed to generate an acid with respect to the total amount of the composition for preparing a carbon dioxide external preparation is not particularly limited and can be appropriately selected depending on the purpose. When the content is less than 10% by mass, the amount of carbon dioxide generated by the reaction between the hydrolyzed acid and the carbonate decreases, and the effect as an external preparation obtained by carbon dioxide generation is not sufficiently exhibited. . On the other hand, when the content exceeds 20% by mass, it is difficult to stir and mix with other components. Therefore, the content is preferably 10% by mass or more and 20% by mass or less, and more preferably 13% by mass or more and 18% by mass.

The polyhydric alcohol is not particularly limited as long as it has two or more hydroxyl groups in its molecular structure, and can be appropriately selected depending on the purpose. Examples include ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin, 1,8-octanediol, glycerin that is a sugar alcohol, sorbitol, and trehalose that is also a sugar. These may be used alone or in combination of two or more. Among them, 1,3-butylene glycol is preferable from the viewpoint of shortening the gelation time and moisturizing.

The content of the polyhydric alcohol with respect to the total amount of the composition for preparing a carbon dioxide external preparation is not particularly limited and can be appropriately selected depending on the purpose. When the content is less than 5% by mass, the composition for preparing a carbon dioxide external preparation has a longer time for gelation after mixing two or more agents, and the composition for preparing a carbon dioxide external preparation by the end of use. Cannot be gelled so that it can be peeled off by hand. On the other hand, when the content exceeds 25% by mass, the coated surface hardens in such a state that the carbon dioxide external preparation preparation composition does not adhere to the hand that touched the coated surface from mixing to coating. The mass is preferably from 25% by mass to 25% by mass, and more preferably from 5% by mass to 20% by mass.

The water contained in the composition for preparing a carbon dioxide external preparation is not particularly limited as long as it is water used for normal cosmetics, pharmaceuticals, and the like, and can be appropriately selected depending on the purpose. For example, distilled water, membrane permeated water, and ion exchange water can be mentioned. These may be used individually by 1 type, may use 2 or more types together, and may be contained as aqueous solution of other components, such as calcium chloride aqueous solution.

The content of the water with respect to the total amount of the composition for preparing a carbon dioxide external preparation is not particularly limited and can be appropriately selected depending on the purpose. The content is a total of water and water contained in other components such as the water-soluble calcium salt, and is prepared so that the total amount of the carbon dioxide external preparation preparation composition is 100% by mass. Is done. Further, when the content is less than 55% by mass, the viscosity becomes high and fluidity, flexibility, and solubility of other components are lacking. Therefore, the content is preferably 55% by mass or more.

Other components of the carbon dioxide external preparation preparation composition are not particularly limited as long as they are components used in cosmetics and skin external preparations, and can be appropriately selected depending on the purpose. For example, surfactants, pH adjusters, humectants, preservatives, antioxidants, fragrances, dispersants, ultraviolet absorbers, dyes and the like can be mentioned. These may be used individually by 1 type and may use 2 or more types together.

The usage form of the carbon dioxide external preparation is not particularly limited and can be appropriately selected depending on the purpose. For example, a form used by mixing two or more gel-like agents when applied to the skin, etc., a form used by mixing two or more gel-like and granular agents when applied to the skin, granules, etc. Examples include a form in which a gel-like agent is mixed with water after being dissolved in water and then mixed at the time of application to the skin.

The method for evaluating the goodness of elongation of the carbon dioxide external preparation preparation composition when applied to the skin or the like is not particularly limited as long as it can show the goodness of elongation of the applied gel, and is selected according to the purpose. can do. For example, after mixing two or more agents and applying to the skin etc., the “time until the gel does not adhere to the finger when the application surface is touched” is defined as “the time when the application surface starts to solidify”, There is a method of evaluating the goodness of elongation by the length of the “time when the coated surface starts to harden”.

After the application of the composition for preparing a carbon dioxide external preparation to the skin or the like, the evaluation method of the ease of peeling at the end of use can be any method that can show the ease of peeling and the tendency of the applied gel to be solidified. There is no particular limitation, and it can be selected according to the purpose. For example, after mixing two or more agents and applying to the skin etc., the “time until the gel does not remain on the skin when peeled” is defined as “the time to peel off”, and the “time to peel off” There is a method of evaluating long and short in comparison with use time.

The method for evaluating the amount of carbon-permeable carbon dioxide generated in the composition for preparing a carbon dioxide external preparation is particularly limited as long as it can measure the amount of carbon dioxide that permeates through a membrane simulating a human skin environment. It can be appropriately selected depending on the purpose. For example, a method of immersing a porous polymer membrane in oil and fat and measuring the amount of carbon dioxide that permeates the membrane can be mentioned. In order to approach the human skin environment, a microporous film (manufactured by Sumitomo 3M, 3M microporous film, pore size of 0.3 μm or less) is used for the porous polymer film, and olive squalane (Kishimoto Special) is used for the fats and oils. A method using a carbon dioxide concentration meter (manufactured by Toa DKK Co., Ltd., model number CGP-31) is particularly preferable for measuring the amount of carbon dioxide permeated through a liver oil industry plant, plant squalane.

Specifically, evaluation of the amount of membrane-permeable carbon dioxide generated in the composition for preparing a carbon dioxide external preparation was carried out by putting 1 g of a gel in which two or more agents were stirred and mixed into a container dedicated to a carbon dioxide concentration meter. Then, a microporous film coated with 0.1 g of olive squalane is covered, and a detector of a carbon dioxide concentration meter is attached to the dedicated container. A predetermined amount of water is added using a syringe so as to fill the space between the container and the detector, and the amount of membrane-permeable carbon dioxide generated is measured and recorded for 60 minutes every minute immediately after.

As a method for evaluating the composition for preparing a carbon dioxide external preparation, the carbon dioxide generated from the composition for preparing a carbon dioxide external preparation is further measured by further measuring the pH of the composition for preparing a carbon dioxide external preparation when membrane-permeable carbon dioxide is generated. The state of carbon can be confirmed.
The method for measuring the pH is not particularly limited as long as it is a method capable of measuring the change over time of the pH of the composition for preparing an external preparation for carbon dioxide, and can be appropriately selected depending on the purpose. For example, a method of stirring and mixing two or more agents and measuring the pH of the composition for preparing a carbon dioxide external preparation over time using an everyday waterproof pH meter (manufactured by HANNA instruments, pHep4 HI98127) can be mentioned.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples.

(Examples 1 to 9 and Comparative Examples 1 to 3)
According to the composition described in Table 1, a composition for preparing a carbon dioxide external preparation was prepared. In the examples in which magnesium carbonate that also serves as a magnesium salt and carbonate was blended, a composition for preparing a carbon dioxide external preparation was prepared with the blending amount of magnesium carbonate described in the table. And 0035 and the like, it was considered that the same amount of magnesium salt and carbonate was mixed.
According to the blending amount described in Table 2, the agent divided into two was stirred and mixed until it became uniform visually before use.

About the composition for preparing carbon dioxide external preparations prepared in Examples 1 to 9 and Comparative Examples 1 to 3, the composition for preparing carbon dioxide external preparations was mixed according to the following evaluation method. Evaluation of good elongation at the time of application and ease of peeling at the end of use.
After mixing two or more agents on the skin or the like, the “time until the gel does not adhere to the finger when the application surface is touched” is defined as the “time when the application surface starts to solidify”, and the “application surface is The time to start setting was measured. Next, after mixing two or more agents and applying to the skin, etc., the “time until the gel does not remain on the skin when peeled” was defined as the “time to remove”, and the “time to remove” was measured. . Then, specify the appropriate “time for the coated surface to start to solidify” based on the time to apply two or more agents to the skin, etc., and specify the appropriate “time to peel off” based on the usage time. did. If both “time when the coated surface starts to solidify” and “time to peel off” are within the specified time, it is evaluated as “good (◎)”, and if both are not within the specified time, “bad (△)”. If one is within the specified time and the other is not within the specified time, it is evaluated as “Normal (○)”. If it does not solidify or peel off after 60 minutes after mixing, X) ".
In the examples and comparative examples described, since the time for applying two or more agents of the composition for preparing a carbon dioxide external preparation to the skin after mixing was within 5 minutes, the time for the appropriate application surface to start to solidify was It was defined as 5-10 minutes. Further, in the examples and comparative examples described, the use time of the composition for preparing a carbon dioxide external preparation was 10 to 15 minutes, so the appropriate peeling time was defined as 10 to 15 minutes.
Table 3 shows the evaluation results of good elongation at the time of application to the skin after mixing and ease of peeling at the end of use.

From Table 3, compared with Examples 1, 2 and 6 which were good (◎) evaluation, Comparative Example 2 which does not contain a water-soluble calcium salt does not peel off after use, and is a water-soluble calcium salt. In Examples 3 and 4 where the compounding amount of calcium chloride is large, it was found that the time when the coating surface started to solidify was short and the elongation during coating was not good. Further, in Comparative Example 1 in which magnesium carbonate is changed to sodium hydrogen carbonate, neither the coating surface nor the inside is hardened, and in Examples 7 and 8 in which the blending amount of magnesium carbonate is further increased, the time at which the coating surface begins to harden and the time to peel off are short. I found out that

About the composition for carbon dioxide external preparation preparation obtained by preparing in Example 1 and Comparative Example 3, the amount of membrane-permeable carbon dioxide generation was evaluated by the following method.
For Examples and Comparative Examples, 1 g of gel mixed with the two agents listed in Table 2 was put in a container dedicated to a carbon dioxide concentration meter, and a microporous film coated with 0.1 g of olive squalane was placed thereon, and the dedicated container Attach a carbon dioxide concentration meter detector. A predetermined amount of water was added using a syringe so as to fill the space between the container and the detector, and the amount of carbon dioxide permeated through the membrane was measured and recorded every minute for 60 minutes.
Table 4 shows the test results of the amount of generated carbon permeable carbon dioxide.

Based on Table 4, the time-dependent change of the membrane-permeable carbon dioxide generation amount of Example 1 and Comparative Example 3 is shown in FIG.
From Table 4 and FIG. 1, when Example 1 was compared with Comparative Example 3 not containing magnesium ions and water-soluble calcium salt, the membrane-permeable dioxide up to 15 minutes, which was the assumed usage time of Example 1 after mixing, It can be seen that the carbon generation amount is about 1.2 times the membrane-permeable carbon dioxide generation amount of Comparative Example 3.

The pH was measured by the following method. The two agents described in Example 1 and Comparative Example 3 were stirred and mixed, and the pH of the composition for preparing a carbon dioxide external preparation was measured over time using an everyday waterproof pH meter (manufactured by HANNA instruments, pHep4 HI98127). .
The measurement results of pH are shown in Table 5 and FIG.

From Table 5 and FIG. 2, in Example 1, the pH drops immediately after mixing the two agents, and is maintained at pH 4.0 to 6.5 where membrane-permeable carbon dioxide is likely to be generated until 60 minutes have passed. I understood that.

From Tables 3 to 5 and FIGS. 1 and 2, when the composition for preparing carbon dioxide external preparations divided into two or more agents is applied on the skin after mixing, it is applied to the hand touching the application surface from mixing to application. The coating surface does not harden in such a state that the composition for preparing a carbon dioxide external preparation does not adhere, and the carbon dioxide external preparation composition is gelled so that the composition for preparing a carbon dioxide external preparation can be peeled off by the end of use. It turned out that the composition for carbon external preparation preparation can be provided. That is, it was found that when the composition for preparing an external preparation for carbon dioxide was applied to the skin or the like, the elongation was good, and it solidified to the extent that it could be peeled by hand after the use time.
Further, the composition for preparing a carbon dioxide external preparation of the present invention comprises a magnesium salt, a water-soluble calcium salt, a gelling agent that gels with magnesium ions or calcium ions, a carbonate, a substance that is hydrolyzed to produce an acid, a polyvalent By containing alcohol and water, the preparation of a carbon dioxide external preparation comprising a component that is maintained at a pH of 4 to 6.5 and is known in Patent Document 2 in the period from the start of use to the end of use It has been found that membrane permeable carbon dioxide is generated in an amount exceeding the amount of membrane permeable carbon dioxide generated from the composition for use.

These effects are based on several factors. First, the effect is that by blending a component that generates magnesium ions such as magnesium carbonate, the ionic crosslinking of gelling agents such as sodium alginate and xanthan gum is made more gradual than when a component that generates calcium ions is blended. based on. The blending of magnesium ions improves the elongation of the composition for preparing a carbon dioxide external preparation immediately after mixing, and contributes to hardening the entire gel. Further, the effect is that by adding calcium chloride, which is a water-soluble calcium salt, as a component that generates calcium ions, a gelling agent such as sodium alginate or xanthan gum is more effective than when water-insoluble or poorly water-soluble calcium carbonate is added. Based on accelerating ionic crosslinking of The formulation of water-soluble calcium ions contributes to hardening the coating surface of the carbon dioxide external preparation preparation composition immediately after mixing. Moreover, the said effect is based on the fact that the ionic crosslinking of the gelling agent can be accelerated by increasing the blending amount of butylene glycol which is a polyhydric alcohol. The blend of butylene glycol contributes to the good elongation of the composition for preparing a carbon dioxide external preparation immediately after mixing and the adjustment of the peeling time.
And the said effect adjusts the time which a coating surface begins to solidify, and the time to peel off by mix | blending an appropriate quantity of the component which produces magnesium ions, such as magnesium carbonate, and a water-soluble calcium salt, From the composition for carbon dioxide external preparation preparation This is based on the fact that the generated membrane-permeable carbon dioxide can be released out of the composition for preparing a carbon dioxide external preparation. The appropriate amount of the component that generates magnesium ions and the water-soluble calcium salt is selected from the conventionally known components that are mixed in an appropriate amount of water-insoluble or poorly water-soluble calcium salt as the component that generates calcium ions and do not include the component that generates magnesium ions. More membrane-permeable carbon dioxide can be generated than the amount of membrane-permeable carbon dioxide generated from the composition for preparing a carbon dioxide external preparation.

The composition for preparing an external preparation for carbon dioxide of the present invention is easy to mix and prepare two or more agents, has a good elongation without being hardened by the time of application on the skin immediately after mixing, and the use time is over. It can be peeled off so as not to remain on the skin, and a sufficient amount of membrane-permeable carbon dioxide can be generated within the use time. Therefore, in a cosmetic pack that can continue moderate irritation to the skin, it stretches well at the time of application, peels off cleanly at the end, and has an effect as a so-called carbon dioxide gas pack. It can be suitably used for cosmetics such as agents, external preparations for skin, quasi-drugs such as hair preparations, pharmaceuticals, and pet products.

The composition for preparing a carbon dioxide external preparation of the present invention has a characteristic that it is well stretched at the time of application and can be peeled off at the end of use, which is said to be incompatible with a so-called carbon dioxide gas pack in the beauty industry. For this reason, until now it was necessary to wipe off the lump of gel that could not be peeled off at the end of use with a towel, and there was a secondary problem in the washing process of towels that had been wiped off lump of gel. Solves such secondary problems.

Claims (7)

1. Preparation of topical carbon dioxide preparation containing at least magnesium salt, water-soluble calcium salt, gelling agent that gels with magnesium ion or calcium ion, carbonate, substance that generates acid upon hydrolysis, polyhydric alcohol and water Composition.
2. When the carbon dioxide external preparation preparation composition divided into two or more is applied on the skin after mixing so that at least the carbonate and the substance that generates acid upon hydrolysis are separately mixed, from mixing to application The composition for preparing a carbon dioxide external preparation according to claim 1, wherein the coating surface does not solidify and gels so that the composition for preparing a carbon dioxide external preparation can be peeled from the skin by the end of use.
3. Membrane-permeable carbon dioxide generation when the amount of carbon-permeable carbon dioxide generated is mixed with the composition for preparation of carbon dioxide external preparation prepared by changing the water-soluble calcium salt to a water-insoluble or poorly water-soluble calcium salt except for the magnesium salt The composition for preparing a carbon dioxide external preparation according to claim 1 or 2, wherein a magnesium salt and a water-soluble calcium salt are blended so as to have a period exceeding the amount.
4. Content of the said magnesium salt with respect to the said composition for carbon dioxide external preparation preparation is 0.3 mass% or more and 12 mass% or less, Content of the said water-soluble calcium salt with respect to the said total composition for carbon dioxide external preparation preparation Is 0.003% by mass or more and 0.05% by mass or less, and the content of the gelling agent gelled by the magnesium ions or calcium ions with respect to the total amount of the composition for preparing a carbon dioxide external preparation is 1.0% by mass or more. 7% by mass or less, and the content of the carbonate with respect to the total amount of the carbon dioxide external preparation preparation composition is 0.3% by mass or more and 12% by mass or less, and the carbon dioxide external preparation preparation total amount The content of the substance that is hydrolyzed to generate an acid is 10% by mass or more and 20% by mass or less. The alcohol content is 25 mass% or more 5 wt%, carbon dioxide external preparation prepared composition according to any one of claims 1 to 3.
5. The essential components are at least a magnesium salt, a water-soluble calcium salt, a gelling agent that gels with magnesium ions or calcium ions, a carbonate, a substance that is hydrolyzed to generate an acid, a polyhydric alcohol, and water. The manufacturing method of the composition for carbon dioxide external preparation preparation in any one of these.
6. A carbon dioxide external preparation using the composition for preparing carbon dioxide external preparation according to any one of claims 1 to 4.
7. A cosmetic pack using the carbon dioxide external preparation preparation composition according to any one of claims 1 to 4.

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