CN106535864A - Composition for preparing carbon dioxide formulation for external use, method for producing same, method for evaluating same, and carbon dioxide formulation for external use - Google Patents
Composition for preparing carbon dioxide formulation for external use, method for producing same, method for evaluating same, and carbon dioxide formulation for external use Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention addresses the problem of providing a novel composition for preparing carbon dioxide formulation for external use, said composition being highly spreadable on the skin immediately after mixing two or more agents until applying to the skin while preventing the surface of the applied composition from beginning to solidify, being capable of gelling so that the composition can be separated from the skin without remaining on the skin at the end of the use, and, during use period, generating membrane permeable carbon dioxide in an amount greater than the amount of membrane permeable carbon dioxide generated by a conventional composition for preparing carbon dioxide formulation for external use that comprises known components. Also, the present invention addresses the problem of providing a carbon dioxide formulation for external use and a cosmetic pack that are obtained from the novel composition for preparing carbon dioxide formulation. The composition for preparing carbon dioxide formulation at least comprises, as essential components, a gelling agent that gels in the presence of a magnesium salt, a water-soluble calcium salt, magnesium ion or calcium ion, a carbonic acid salt, a substance that generates an acid when hydrolyzed, a polyhydric alcohol and water.
Description
Technical field
The present invention relates to it is a kind of for preparing using two or more preparation when the group of carbon dioxide preparation for external use that mixed
Compound.
Background technology
It is known to have one kind for beauty, medical effect purpose, mix the alkalescence containing carbonate in the presence of water
The acidic composition such as compositionss and water soluble acid, and make which produce the technology of carbon dioxide (with reference to patent documentation 1 etc.).
And, it is also known that have it is a kind of by by Jing hydrolyze produce acid material, carbonate, thickening agent, water, by calcium ion
The gelating agent and water-insoluble or slightly water-soluble calcium salt of gelation is used as neccessary composition such that it is able to easily prepares and continues
Ground percutaneous, through mucous membrane absorbing carbon dioxide, and the higher carbon dioxide preparation for external use of beauty and medical effect is (with reference to patent documentation
2 etc.).
Compositionss for preparing carbon dioxide preparation for external use are to be mixed when using two or more preparation and made which anti-
Answer and the material of generation carbon dioxide.
It is also known that cosmetic pack preparation will used for the compositionss for preparing carbon dioxide preparation for external use
In the case of, in the compositionss for preparing carbon dioxide preparation for external use, addition is by the gelating agent of calcium ion gelation, water
Insoluble or slightly water-soluble calcium salt such that it is able to be used in the compositionss solidification for preparing carbon dioxide preparation for external use.
However, exist being used according to the species and proportioning of the gelating agent and the water-insoluble or slightly water-soluble calcium salt
Become unsuitable problem in the speed of the gelation of the compositionss for preparing carbon dioxide preparation for external use and/or the hardness of gel.
That is, if gelation is too fast, there is autgmentability when skin etc. is applied to for the compositionss for preparing carbon dioxide preparation for external use and become
Difference, and the problem of enough carbon dioxide cannot be produced.If conversely, gelation is excessively slow, existing and being difficult with handss from skin table
The compositionss for preparing carbon dioxide preparation for external use are peeled off in face, and are difficult to the problem as pack preparation.
Prior art literature
Patent documentation
Patent documentation 1：No. 4248878 publications of Japanese Patent No.
Patent documentation 2：No. 4595058 publications of Japanese Patent No.
The content of the invention
Technical problem
The problem of the present invention is to provide a kind of new compositionss for preparing carbon dioxide preparation for external use, is mixed just
When being applied to skin etc. after closing two or more preparation, autgmentability is good, and producing ratio from including it is well known so far into
Point the more membrane permeabilities of membrane permeability amount of carbon dioxide two that produce of the compositionss for preparing carbon dioxide preparation for external use
Carbonoxide, also, solidify through to use time.Also, the problem of the present invention is also to provide a kind of new by this
The carbon dioxide preparation for external use obtained for the compositionss for preparing carbon dioxide preparation for external use and cosmetic facial film.
Technical scheme
Jing the present inventor etc. is concentrated on studies to above-mentioned situation, is as a result found by magnesium salt, water-soluble Ca salt, by magnesium
The gelating agent of ion or calcium ion gelation, carbonate, Jing hydrolysis produce material, polyhydric alcohol and the water of acid as neccessary composition
The compositionss for preparing carbon dioxide preparation for external use.
Invention effect
In accordance with the invention it is possible to provide the following compositionss for being used for preparing carbon dioxide preparation for external use：By containing magnesium salt,
Water-soluble Ca salt, the gelating agent by magnesium ion or calcium ion gelation, carbonate, Jing hydrolysis produce the material, polynary of acid
Alcohol and water, so that be classified into 2 in the way of at least individually coordinating the carbonate and Jing hydrolysis to produce the material of acid
The feelings that the compositionss for preparing carbon dioxide preparation for external use of kind above preparation are applied on skin after being mixed
Under condition, coating surface from be mixed into coating when till to touch, the attachment on hand of the coating surface is upper to be used for preparing carbon dioxide
The state solidification of the compositionss of external preparation, and for preparing the compositionss of carbon dioxide preparation for external use at the end of use being
Skin is not residued in only and gelation is to peelable.I.e., using the teaching of the invention it is possible to provide will be used for preparing the compositionss of carbon dioxide preparation for external use
Autgmentability when being applied to skin etc. it is good and be solidified to after use time degree that available handss are peeled off for preparing
The compositionss of carbon dioxide preparation for external use.
Also, the compositionss for preparing carbon dioxide preparation for external use of the invention, by containing magnesium salt, water solublity
Calcium salt, the gelating agent by magnesium ion or calcium ion gelation, carbonate, Jing hydrolysis produce sour material, polyhydric alcohol and water,
So as to produce more than from the combination for preparing carbon dioxide preparation for external use including the medium composition for knowing of patent documentation 2
The membrane permeability carbon dioxide of the amount of the membrane permeability amount of carbon dioxide that thing is produced.
Description of the drawings
Fig. 1 is to represent embodiment 1 and the time dependent curve of membrane permeability carbon dioxide yield in comparative example 3
Figure.
Fig. 2 is to represent embodiment 1 and the pH value time history plot in comparative example 3.
Specific embodiment
The compositionss for preparing carbon dioxide preparation for external use of the present invention are used for carrying out when preparing using two or more preparation
The carbon dioxide preparation for external use of mixing, which is at least containing magnesium salt, water-soluble Ca salt, by the solidifying of magnesium ion or calcium ion gelation
Gelatinizing agent, carbonate, Jing hydrolysis produce sour material, polyhydric alcohol and water, it is also possible to further contain other compositions as needed.
As long as the magnesium salt has magnesium in its chemical structural formula and generates magnesium ion in water just it is not particularly limited,
Can be properly selected according to purpose.Magnesium oxide, magnesium carbonate, magnesium sulfate, aluminium-magnesium silicate, L-AA -2- can for example be enumerated
Magnesium phosphorate, magnesium silicate, magnesium stearate, magnesium hydroxide, magnesium acetate, Malic acid magnesium salt (1:1)., magnesium citrate etc..These can be used alone
1 kind, it is also possible to and use two or more, and other neccessary compositions such as carbonate can also be had concurrently.Wherein, preferably magnesium carbonate and oxidation
Magnesium etc., further preferably has concurrently as preparing the carbon of the carbonate of the neccessary composition of the compositionss of carbon dioxide preparation for external use
Sour magnesium.
The magnesium salt does not have relative to the content for preparing the total composition of carbon dioxide preparation for external use
Especially limit, can be properly selected according to purpose.If the content starts to coagulate more than 12 mass %, whether coating surface
Solid time or whole gel sets to peel off when do not residue in skin time of degree all become too short.On the other hand,
If the content is less than 0.3 mass %, whether coating surface starts the time for solidifying or whole gel sets to stripping
When do not residue in skin time of degree all become long, therefore preferably 0.3 mass %, less than 12 mass %, is entered
One step is preferably more than 0.5 mass % and below 11 mass %.
As long as the water-soluble Ca salt has calcium in its chemical structural formula and has water solublity, and generates in water
Calcium ion is just not particularly limited, and can be properly selected according to purpose.Calcium chloride, calcium lactate etc. can for example be enumerated.These can
To be used alone a kind, it is also possible to and two or more is used, other neccessary compositions can also be had concurrently.Wherein it is preferred for preparing titanium dioxide
The compositionss of the carbon external preparation calcium salt that gelation is peeled off to available handss at the end of use, from the dissolubility in water
From the aspect of, further preferred calcium chloride.
Water-soluble Ca salt (the removing the water in the water-soluble Ca salt) relative to described for preparing outside carbon dioxide
It is not particularly limited with the content of the total composition of preparation, can be properly selected according to purpose.If the content is less than
0.003 mass %, then the compositionss for preparing carbon dioxide preparation for external use fully do not coagulate to using the end time
Gel and become to be not easily stripped.On the other hand, if the content is more than 0.05 mass %, when coating surface is mixed into coating certainly
Till easily solidify, therefore more than preferably 0.003 mass % and below 0.05 mass %, more preferably 0.003 matter
Below amount more than % and 0.03 mass %.
As long as by the gelating agent of the magnesium ion or calcium ion gelation by the magnesium that produced by the magnesium salt from
Son and/or the calcium ion that produced by the water-soluble Ca salt etc. and gelation is just not particularly limited, can be appropriate according to purpose
Ground is selected.Carrageenan, xanthan gum, tara gum, sodium alginate etc. can for example be enumerated.These can be used alone, it is also possible to and
Use two or more.Wherein, from from the aspect of the slickness and ease for use of coating state, preferably sodium alginate and xanthan gum.
The gelating agent by magnesium ion or calcium ion gelation relative to described for preparing outside carbon dioxide
It is not particularly limited with the content of the total composition of preparation, can be properly selected according to purpose.If the content is less than
1.0 mass %, then the gelation for preparing the compositionss of carbon dioxide preparation for external use is not abundant enough, and is difficult to be made
For the effect of preparation for external application to skin.On the other hand, if more than 7 mass %, the coating surface easily to be mixed into coating certainly when
Till touch coating surface do not adhere on hand for prepare carbon dioxide preparation for external use compositionss state solidify, therefore
More than preferably 1.0 mass % and below 7 mass %, more than further preferred 2 mass % and below 5 mass %.
As long as the carbonate and Jing hydrolysis contained in the compositionss for preparing carbon dioxide preparation for external use
The carbonate that the material of generation acid is reacted and produced carbon dioxide is just not particularly limited, and can suitably be selected according to purpose
Select.Can for example enumerate ammonium carbonate, ammonium hydrogen carbonate, potassium carbonate, potassium bicarbonate, sodium carbonate, sodium bicarbonate, magnesium carbonate, magnesium bicarbonate,
Calcium Carbonate, calcium bicarbonate, brium carbonate etc..These can be used alone or two or more kinds may be used, and can also have magnesium salt concurrently
Or other neccessary compositions such as calcium salt.The magnesium carbonate of the generation of magnesium ion is more preferably had concurrently wherein.
The carbonate relative to the content for preparing the total composition of carbon dioxide preparation for external use not
There is especially restriction, can be properly selected according to purpose.If the content is less than 0.3 mass %, the yield of carbon dioxide
Tail off, it is difficult to give full play to by producing the effect obtained from carbon dioxide as external preparation.On the other hand, if described contain
Amount is uprised more than 12 mass %, the then pH for preparing the compositionss of carbon dioxide preparation for external use, produced titanium dioxide
Easily so that carbonate ions are present, membrane permeability carbon dioxide yield tails off carbon, therefore more than preferably 0.3 mass % and 12
Below quality %, more than more preferably 0.5 mass % and below 11 mass %.
As long as the material that the material of the Jing hydrolysis generation acid has more than 1 ring-type ester bond in its molecular structure is just
It is not particularly limited, can be properly selected according to purpose.Glucose lactone, pantothenic acid lactone, D, L- or L- third can for example be enumerated
Lactide (3,6- dimethyl -1,4- dioxane -2,5- diketone), D, L- or L- Acetic acid, hydroxy-, bimol. cyclic esters, phthalic anhydride, maleic anhydride, amber
Amber anhydride etc..These can be used alone or two or more kinds may be used.Wherein preferred glucose lactone and D, L- lactide
Deng, in terms of the formation speed of the acid reacted from hydrolysis rate and with carbonate, compound obtain easiness from the aspect of,
Further preferred glucose lactone.
The Jing hydrolysis produces the total relative to the compositionss for preparing carbon dioxide preparation for external use of the material of acid
The content of amount is not particularly limited, and can be properly selected according to purpose.If the content is less than 10 mass %, by hydrolyzing
The acid for obtaining and the reaction of carbonate and the yield of carbon dioxide that produces tails off, and be difficult to give full play to by producing dioxy
Change the effect as external preparation obtained from carbon.On the other hand, if the content is more than 20 mass %, be difficult to other into
Point stirring mixing, therefore more than preferably 10 mass % and below 20 mass %, more than more preferably 13 mass % and 18
Quality %.
As long as the alcohol that the polyhydric alcohol has more than 2 hydroxyls in its molecular structure is then not particularly limited, can be with
Properly selected according to purpose.Ethylene glycol, Propylene Glycol, 1,3 butylene glycol, Polyethylene Glycol, glycerol, 1,8- pungent two can for example be enumerated
Alcohol and the glycerol also as sugar alcohol, Sorbitol, also as sugared trehalose etc..These can be used alone, it is also possible to and
Use two or more.Wherein, from from the aspect of the effect and moisturizing for shortening gelation time, preferred 1,3 butylene glycol.
The polyhydric alcohol relative to the content for preparing the total composition of carbon dioxide preparation for external use not
There is especially restriction, can be properly selected according to purpose.If the content is less than 5 mass %, described for preparing titanium dioxide
The time of the compositionss of carbon external preparation gelation after two or more preparation is mixed is elongated, and to using the end time
Cannot be used in and prepare the composition gels of carbon dioxide preparation for external use and peel off to available handss.On the other hand, if the content
More than 25 mass %, then the coating surface from be mixed into coating when till to touch, the attachment on hand of coating surface is upper to be used for making
The state solidification of the compositionss of standby carbon dioxide preparation for external use, therefore more than preferably 5 mass % and below 25 mass %, enter one
Step is preferably more than 5 mass % and below 20 mass %.
As long as in the compositionss for preparing carbon dioxide preparation for external use contained water for general cosmetics,
The water of pharmaceuticals etc., then be not particularly limited, and can be properly selected according to purpose.Can for example enumerate distilled water, membrane permeation water,
Deionized water.These can be used alone or two or more kinds may be used, be also used as calcium chloride water etc. other into
Point aqueous solution and contained.
Not having relative to the content for preparing the total composition of carbon dioxide preparation for external use for the water is special
Do not limit, can be properly selected according to purpose.Also, the content be amounted to the water and the water-soluble Ca salt etc. its
In his composition, the content of contained water, becomes 100 matter with the total composition for preparing carbon dioxide preparation for external use
The mode of amount % is prepared.If also, the content be less than 55 mass %, viscosity is uprised and mobility, flexibility and
Dissolubility of other compositions etc. is short of, therefore the content is preferably more than 55 mass %.
As long as the other compositions for preparing the compositionss of carbon dioxide preparation for external use are used for cosmetics and skin
The composition of external preparation is just not particularly limited, and can be properly selected according to purpose.Surfactant, pH can for example be enumerated to adjust
Section agent, wetting agent, preservative, antioxidant, spice, dispersant, UV absorbent and pigment etc..These can be used alone
1 kind, it is also possible to and use two or more.
The use form of the carbon dioxide preparation for external use is not particularly limited, and can be properly selected according to purpose.
Can for example enumerate mixed to use when gelatinous two or more preparation is applied to skin etc. form, by gel and
Form that granular two or more preparation is mixed to use when being applied to skin etc., in water dissolved particles shape preparation it
Form for being mixed to use when gel preparation being applied to skin etc. afterwards etc..
Whether the autgmentability when compositionss for preparing carbon dioxide preparation for external use are applied to skin etc. is good
As long as evaluation methodology can show that the whether good method of the autgmentability of be coated with gel is just not particularly limited, can be with root
Select according to purpose.For example, following method can be enumerated：Skin etc. will be applied to start " to touching from after mixing two or more preparation
Time till gel is not attached to finger during coating surface " is defined as " coating surface starts the time for solidifying ", and " is applied with this
Cloth surface start solidify time " length it is whether good to evaluate autgmentability.
After the compositionss for preparing carbon dioxide preparation for external use are applied to skin etc., using when terminating
As long as the evaluation methodology of release performance shows the release performance of be coated with gel, the method for easy coagulability is not just especially limited
System, can be selected according to purpose.Following method can for example be enumerated：Skin will be applied to from after mixing two or more preparation
" splitting time " is defined as etc. " time gel does not residue in skin when peeling off " is started, and will be somebody's turn to do " splitting time "
Length is contrasted with use time and is evaluated.
The evaluation for preparing the yield of the membrane permeability carbon dioxide of the compositionss of carbon dioxide preparation for external use
As long as the method that method can measure the amount of carbon dioxide of the film of the skin environment of simulation of infiltration people is just not particularly limited, can
To be properly selected according to purpose.Can for example enumerate porous polymer membrane is impregnated in oils and fatss the two of the film is permeated to measure
The method of carbon oxide amount.Due to being close to the skin environment of people, so as the porous polymer membrane, particularly preferably using micro-
Pore membrane (microporous film) (Sumitomo 3M Limited company systems, 3Mmicroporous film, aperture
Less than 0.3 μm), as the oils and fatss, particularly preferably use Fructus Canarii albi Squalene (olive squalene) (kishimoto
Special liver oil co., ltd. systems, vegetalitas Squalene), two are used when the membrane permeation amount of carbon dioxide is measured
The method of carbonoxide densitometer (DKK-TOA Co. Ltd. systems, model C GP-31).
The evaluation for preparing the yield of the membrane permeability carbon dioxide of the compositionss of carbon dioxide preparation for external use
It is specific as follows：The 1g gels that stirring is mixed with two or more preparation are put in carbon dioxide concentration special container, from it
Side covers the microporous membrane for being coated with 0.1g Fructus Canarii albi Squalenes, and installs the detector of carbon dioxide concentration in the special container.
The water of scheduled volume is added using syringe, so that water is full of between the container and detector, afterwards per 1 in 60 minutes
Minute determines membrane permeability carbon dioxide yield and records.
As the evaluation methodology for preparing the compositionss of carbon dioxide preparation for external use, by producing membrane permeability
PH for prepare the compositionss of carbon dioxide preparation for external use is determined during carbon dioxide further such that it is able to confirmed from for making
The state of the carbon dioxide that the compositionss of standby carbon dioxide preparation for external use are produced.
As long as the assay method of the pH can determine described for preparing the compositionss of carbon dioxide preparation for external use
The time dependent methods of pH are just not particularly limited, and can be properly selected according to purpose.2 kinds of stirring mixing can for example be enumerated
Above preparation, and daily water proof type pH meter (HANNA instruments systems, pHep4 HI98127) is used, temporally determine and use
In the method for the pH of the compositionss for preparing carbon dioxide preparation for external use.
Embodiment
Hereinafter enumerate embodiment and comparative example to be specifically described the present invention, but the present invention does not receive these embodiments
Any restriction.
(embodiment 1～9 and comparative example 1～3)
The compositionss for preparing carbon dioxide preparation for external use are prepared for according to the composition described in table 1.Should illustrate,
In having coordinated the embodiment of the magnesium carbonate for having magnesium salt and carbonate concurrently, prepared for making with the use level of the magnesium carbonate described in table
The compositionss of standby carbon dioxide preparation for external use, but the matching requirements of the neccessary composition in 4,0034 section and 0035 section of claim etc.
Under, can be considered.
According to the use level described in table 2, it is classified into 2 kinds of preparation and mixes to visually In the view of will stir before use
Become uniform.
[table 1]
Use level (unit in embodiment and comparative example：Quality %)
[table 2]
Use level (the unit of each preparation in embodiment and comparative example：g)
By evaluation methodology described below Jing in embodiment 1～9 and comparative example 1～3 is prepared for preparing
It is applied to after the mixing that the compositionss of carbon dioxide preparation for external use carry out this for the compositionss for preparing carbon dioxide preparation for external use
Whether autgmentability during skin etc. is well and using the evaluation of the release performance when terminating.
Skin etc. will be applied to start " to be not attached to gel during touching coating surface from after mixing two or more preparation
Time till finger " as " coating surface start solidify time ", and measure should " coating surface start solidification when
Between ".Then, skin etc. will be applied to start " when peeling off, gel does not residue in skin from after mixing two or more preparation
Time " conduct " splitting time ", and measure " splitting time ".Then, being applied to skin after mixing two or more preparation
The time of skin etc. is defined and specifies appropriate " coating surface starts the time for solidifying ", and is defined by use time and specifies suitable
When " splitting time ".Will " coating surface start solidify time " and " splitting time " the two times at the appointed time
Situation is evaluated as " good (◎) ", and both of which situation not at the appointed time is evaluated as " poor (△) ", by one of them
In stipulated time, another situation not in the stipulated time is evaluated as " general (zero) ", also will not coagulate through 60 minutes after mixing
Gu or situation about not peeling off is evaluated as " unusable (×) ".
In described embodiment and comparative example, for preparing 2 kinds of the mixing of the compositionss of carbon dioxide preparation for external use
Time of skin etc. is applied to after above preparation within 5 minutes, thus the appropriate coating surface start to solidify when
Between be defined as 5～10 minutes.Also, in described embodiment and comparative example, for preparing carbon dioxide preparation for external use
The use time of compositionss is 10～15 minutes, therefore the appropriate splitting time is defined as 10～15 minutes.
Whether autgmentability when being applied to skin etc. after illustrating mixing in table 3 is well and using easily peelable when terminating
The evaluation result of property.
[table 3]
Evaluation result in embodiment and comparative example
Known according to table 3, be compared with the embodiment 1,2 and 6 for being evaluated as good (◎), do not containing water-soluble Ca salt
In comparative example 2, cannot peel off after end of use, in addition, the calcium chloride as water-soluble Ca salt use level become compared with
In many embodiments 3 and 4, coating surface start solidify time it is shorter and be coated with when autgmentability it is poor.Also, be informed in by
Magnesium carbonate is changed in the comparative example 1 of sodium bicarbonate, no matter coating surface or it is internal do not solidify, and matching somebody with somebody in magnesium carbonate
In the embodiment 7 and 8 that resultant is further increased, either coating surface starts the time for solidifying or splitting time becomes
It is short.
By the following method, for Jing in embodiment 1 and comparative example 3 prepare for preparing external carbon dioxide system
The compositionss of agent carry out the evaluation of membrane permeability carbon dioxide yield.
For embodiment and comparative example, the gel of 2 kinds of preparations 1g being mixed with described in table 2 puts into dense carbon dioxide
In degree meter special container, the microporous membrane of the Fructus Canarii albi Squalene for being coated with 0.1g is covered from the upper side, and is installed in the special container
The detector of carbon dioxide concentration.The water of scheduled volume is added using syringe, so that between the container and detector
Full of water, determined membrane permeation carbon dioxide yield afterwards in 60 minutes per 1 minute and record.
The test result of membrane permeability carbon dioxide yield is shown in table 4.
[table 4]
Membrane permeability carbon dioxide yield
(mg/L)
| Mixed time (minute) | Embodiment 1 | Comparative example 3 |
| 0 | 0 | 0 |
| 1 | 0 | 0 |
| 2 | 10 | 10 |
| 3 | 20 | 20 |
| 4 | 40 | 30 |
| 5 | 80 | 40 |
| 6 | 110 | 100 |
| 7 | 150 | 140 |
| 8 | 180 | 200 |
| 9 | 260 | 280 |
| 10 | 370 | 360 |
| 11 | 520 | 460 |
| 12 | 680 | 560 |
| 13 | 810 | 650 |
| 14 | 930 | 770 |
| 15 | 1050 | 860 |
| 16 | 1190 | 960 |
| 17 | 1330 | 1060 |
| 18 | 1420 | 1140 |
| 19 | 1570 | 1230 |
| 20 | 1670 | 1310 |
| 21 | 1740 | 1380 |
| 22 | 1800 | 1450 |
| 23 | 1830 | 1510 |
| 24 | 1870 | 1560 |
| 25 | 1900 | 1610 |
| 26 | 1910 | 1650 |
| 27 | 1940 | 1680 |
| 28 | 1970 | 1710 |
| 29 | 2000 | 1740 |
| 30 | 2020 | 1770 |
| 31 | 1790 | |
| 32 | 1820 | |
| 33 | 1840 | |
| 34 | 1860 | |
| 35 | 1880 | |
| 36 | 1900 | |
| 37 | 1920 | |
| 38 | 1940 | |
| 39 | 1960 | |
| 40 | 1980 | |
| 41 | 2000 | |
| 42 | 2020 |
According to table 4, the change of the membrane permeability carbon dioxide yield with the time of embodiment 1 and comparative example 3 is figure 1 illustrates
Change.
Known according to table 4 and Fig. 1, embodiment 1 and the comparative example 3 for not containing magnesium ion and water-soluble Ca salt are compared
In the case of, the membrane permeability carbon dioxide yield after mixing to the anticipation use time 15 minutes of embodiment 1 is ratio
Compared with about 1.2 times of the membrane permeability carbon dioxide yield of example 3.
The measure of the pH is by the following method carrying out.2 kinds of systems described in stirring mix embodiment 1 and comparative example 3
Agent, and daily water proof type pH meter (HANNA instruments systems, pHep4 HI98127) is used, temporally determine for preparing
The pH of the compositionss of carbon dioxide preparation for external use.
The measurement result of pH is shown in table 5 and Fig. 2.
[table 5] pH measurement results
(pH)
Known according to table 5 and Fig. 2, in embodiment 1, after 2 kinds of preparations are mixed, pH declines immediately, to through 60 points
Clock, is maintained at the pH 4.0～6.5 for easily producing membrane permeability carbon dioxide.
Known according to table 3～5 and Fig. 1～2, using the teaching of the invention it is possible to provide a kind of to be classified into being used for preparing described in two or more preparation
When the compositionss of carbon dioxide preparation for external use are applied on skin after being mixed, when being mixed into certainly coating till, be coated with table
The no state for preparing the compositionss of carbon dioxide preparation for external use non-cohesive on hand to touch the coating surface in face solidifies,
And at the end of use, for preparing the composition gelsization of carbon dioxide preparation for external use to being used for that available handss are peeled off
Prepare the compositionss of carbon dioxide preparation for external use.That is, know and will be applied to for the compositionss for preparing carbon dioxide preparation for external use
During skin etc., autgmentability is good, and is solidified to the degree that available handss are peeled off after use time.
Also, to know and contain magnesium salt, water-soluble by the compositionss for preparing carbon dioxide preparation for external use for making the present invention
Property calcium salt, the gelating agent by magnesium ion or calcium ion gelation, carbonate, Jing hydrolysis produce acid material, polyhydric alcohol and
Water, in a period of after beginning to use certainly to use terminates, pH maintains 4～6.5, and produces more than from bag
The membrane permeability titanium dioxide that the compositionss for preparing carbon dioxide preparation for external use containing well known composition in patent documentation 2 are produced
The membrane permeability carbon dioxide of the amount of carbon amounts.
Above effect is based on several reasons：First, the effect is based on：By coordinate magnesium carbonate etc. produce magnesium ion into
Point so that compared with the situation of the composition for producing calcium ion has been coordinated, alleviate sodium alginate and xanthan gum isogel agent
Ionomer.The cooperation of magnesium ion contribute to optimizing just mixed for preparing the compositionss of carbon dioxide preparation for external use
Autgmentability makes whole gel sets.Additionally, the effect is based on：By coordinate as water-soluble Ca salt calcium chloride as product
The composition of raw calcium ion, so that, compared with the situation of Calcium Carbonate of water-insoluble or slightly water-soluble has been coordinated, accelerate sodium alginate
And/or the ionomer of xanthan gum isogel agent.The cooperation of water-soluble calcium ion contributes to using from after just being mixed
Solidify in the coating surface of the compositionss for preparing carbon dioxide preparation for external use.Also, the effect is more based on being used as by increasing
The use level of the butanediol of first alcohol such that it is able to accelerate the ionomer of gelating agent.The cooperation of butanediol contributes to adjusting firm
The autgmentability for preparing the compositionss of carbon dioxide preparation for external use for being mixed and splitting time.
And, the effect produces the composition and water-soluble Ca salt of magnesium ion based on by suitably coordinating magnesium carbonate etc., from
And adjust time and/or the splitting time that coating surface starts to solidify, and can be by from for preparing carbon dioxide preparation for external use
Compositionss produce membrane permeability carbon dioxide evolution to be used for prepare carbon dioxide preparation for external use compositionss outside.Produce
The appropriate cooperation of the composition and water-soluble Ca salt of raw magnesium ion can be using water-insoluble or slightly water-soluble calcium salt as generation calcium
The components matching of ion be appropriate and producing ratio mismatch the composition that produces magnesium ion and from comprising it is known so far into
Point the more membrane permeabilities of membrane permeability amount of carbon dioxide two that produce of the compositionss for preparing carbon dioxide preparation for external use
Carbonoxide.
Industrial applicability
The compositionss for preparing carbon dioxide preparation for external use of the present invention not only easily carry out the mixing of two or more preparation
Prepare, and when being applied on skin just mixing after till coating surface do not solidify and autgmentability well, and to making
Skin can not be residued in till being terminated with the time and be peeled off, and can persistently produce enough membrane permeabilities in the use of time
Carbon dioxide.Therefore, in it can keep the appropriate cosmetic facial film for stimulating to skin, during coating, autgmentability is good, at the end of
Thoroughly peel off, and with the so-called effect as carbon dioxide facial film, be used not only for cosmetic facial film, additionally it is possible to be suitable
It is local to use for the non-medical quasi drugss such as cosmetics, preparation for external application to skin, the hair preparations such as exfoliator, pharmaceuticals, house pet
Any articles for use in product.
The present invention the compositionss for preparing carbon dioxide preparation for external use especially with beauty circle gelatinous
The autgmentability in coating that cannot take into account in so-called carbon dioxide facial film is good, strippable feature at the end of use.Therefore,
Although need to wipe the unstripped clean gel not solidified completely with towel so far at the end of use, and clean wiping not having
Have the gel for solidifying completely towel process on there is also subsidiary problem, but the present invention can solve this subsidiary class
Topic.
Claims (7)
1. a kind of compositionss for preparing carbon dioxide preparation for external use, it is characterised in that
At least magnesium salt, water-soluble Ca salt, the gelating agent by magnesium ion or calcium ion gelation, carbonate, Jing hydrolysis are produced
The material of raw acid, polyhydric alcohol and water are used as neccessary composition.
2. compositionss for preparing carbon dioxide preparation for external use according to claim 1, wherein,
Institute of more than two kinds is being classified in the way of the material for being at least independently matched with the carbonate and Jing hydrolysis generation acid
State in the case of being applied on skin after being mixed for the compositionss for preparing carbon dioxide preparation for external use, coating surface is certainly
Will not solidify till when being mixed into coating, and for preparing the compositionss of carbon dioxide preparation for external use at the end of use
Gelation is to can be from skin peeling.
3. compositionss for preparing carbon dioxide preparation for external use according to claim 1 and 2, wherein,
With including membrane permeability carbon dioxide yield more than to remove magnesium salt and by water-soluble Ca salt be changed to water-insoluble or
Film in the case that the compositionss for preparing carbon dioxide preparation for external use of slightly water-soluble calcium salt are mixed oozes
Mode during permeability carbon dioxide yield coordinates magnesium salt and water-soluble Ca salt.
4. compositionss for preparing carbon dioxide preparation for external use according to any one of claim 1 to 3, wherein,
The content of the magnesium salt relative to the total composition for preparing carbon dioxide preparation for external use be 0.3 mass % with
Below upper and 12 mass %；The content of the water-soluble Ca salt is relative to the combination for preparing carbon dioxide preparation for external use
Thing total amount is below more than 0.003 mass % and 0.05 mass %；It is described by magnesium ion or the gelation of calcium ion gelation
The content of agent is more than 1.0 mass % and 7 matter relative to the total composition for preparing carbon dioxide preparation for external use
Amount below %；The content of the carbonate is 0.3 relative to the total composition for preparing carbon dioxide preparation for external use
More than quality % and below 12 mass %；Jing hydrolysis produces the content of the material of acid relative to described for preparing titanium dioxide
The total composition of carbon external preparation is below more than 10 mass % and 20 mass %；The content of the polyhydric alcohol is relative to described
Total composition for preparing carbon dioxide preparation for external use is below more than 5 mass % and 25 mass %.
5. the manufacturer for preparing the compositionss of carbon dioxide preparation for external use any one of a kind of Claims 1-4
Method, it is characterised in that
The compositionss for preparing carbon dioxide preparation for external use are at least by magnesium salt, water-soluble Ca salt, by magnesium ion or calcium
The gelating agent of ionic gelation, carbonate, Jing hydrolysis produce material, polyhydric alcohol and the water of acid as neccessary composition.
6. a kind of carbon dioxide preparation for external use, it is characterised in that the carbon dioxide preparation for external use is that usage right requires 1 to 4
Any one of for preparing the compositionss of carbon dioxide preparation for external use.
7. a kind of cosmetic facial film, it is characterised in that the cosmetic facial film is that usage right is required any one of 1 to 4
For preparing the compositionss of carbon dioxide preparation for external use.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014-143729 | 2014-07-11 | ||
| JP2014143729A JP6080810B2 (en) | 2014-07-11 | 2014-07-11 | Composition for preparing carbon dioxide external preparation, production method and evaluation method thereof, and carbon dioxide external preparation |
| PCT/JP2014/077043 WO2016006127A1 (en) | 2014-07-11 | 2014-10-09 | Composition for preparing carbon dioxide formulation for external use, method for producing same, method for evaluating same, and carbon dioxide formulation for external use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106535864A true CN106535864A (en) | 2017-03-22 |
| CN106535864B CN106535864B (en) | 2020-06-23 |
Family
ID=55063796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480080524.4A Active CN106535864B (en) | 2014-07-11 | 2014-10-09 | Composition for producing carbon dioxide external preparation, method for producing same, carbon dioxide external preparation, and cosmetic mask |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JP6080810B2 (en) |
| KR (2) | KR101958158B1 (en) |
| CN (1) | CN106535864B (en) |
| HK (1) | HK1231368A1 (en) |
| SG (1) | SG11201610558PA (en) |
| WO (1) | WO2016006127A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010083A (en) * | 2018-09-07 | 2018-12-18 | 广州华玺生物科技有限公司 | A kind of carbon dioxide composite facial mask composition of layered structure and preparation method thereof constituted with amphiphilic substance |
| CN114555212A (en) * | 2019-11-29 | 2022-05-27 | 三菱重工工程株式会社 | Method for fixing carbon dioxide |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101132801A (en) * | 2005-01-28 | 2008-02-27 | 新化学人股份有限公司 | Composition for preparing carbon dioxide preparation for external use |
| CN101842078A (en) * | 2007-10-31 | 2010-09-22 | 富士胶片株式会社 | Gel sheet and cosmetic preparation in sheet form using the same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0045493A3 (en) * | 1980-07-31 | 1982-08-11 | Syntex (U.S.A.) Inc. | Composition useful for preparing face masks and process preparing such composition |
| TWI327474B (en) | 2001-04-06 | 2010-07-21 | Neochemir Inc | Kit for preparation of carbon dioxide agent for external use. |
| JP2003089615A (en) * | 2001-09-18 | 2003-03-28 | Pola Chem Ind Inc | Pack cosmetic with marshmallow touch |
| JP4756265B2 (en) * | 2005-10-19 | 2011-08-24 | ネオケミア株式会社 | Carbon dioxide external agent stripping removal method and divalent cation-containing aqueous solution used therefor |
| KR100854017B1 (en) * | 2007-12-12 | 2008-08-26 | (주)이노페이스 | Method of massaging skin having enhanced convenience |
| JP2013079203A (en) * | 2011-10-03 | 2013-05-02 | Ken Hirohashi | Pack |
-
2014
- 2014-07-11 JP JP2014143729A patent/JP6080810B2/en active Active
- 2014-10-09 CN CN201480080524.4A patent/CN106535864B/en active Active
- 2014-10-09 SG SG11201610558PA patent/SG11201610558PA/en unknown
- 2014-10-09 KR KR1020187023249A patent/KR101958158B1/en active IP Right Grant
- 2014-10-09 KR KR1020177003471A patent/KR20170030583A/en active Application Filing
- 2014-10-09 WO PCT/JP2014/077043 patent/WO2016006127A1/en active Application Filing
-
2017
- 2017-05-16 HK HK17104906.6A patent/HK1231368A1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101132801A (en) * | 2005-01-28 | 2008-02-27 | 新化学人股份有限公司 | Composition for preparing carbon dioxide preparation for external use |
| CN101132801B (en) * | 2005-01-28 | 2011-02-23 | 新化学人股份有限公司 | Composition for preparing carbon dioxide preparation for external use |
| CN101842078A (en) * | 2007-10-31 | 2010-09-22 | 富士胶片株式会社 | Gel sheet and cosmetic preparation in sheet form using the same |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010083A (en) * | 2018-09-07 | 2018-12-18 | 广州华玺生物科技有限公司 | A kind of carbon dioxide composite facial mask composition of layered structure and preparation method thereof constituted with amphiphilic substance |
| CN109010083B (en) * | 2018-09-07 | 2021-11-02 | 广州华玺生物科技有限公司 | Carbon dioxide composite facial mask composition with layered structure composed of amphiphilic substances and preparation method thereof |
| CN114555212A (en) * | 2019-11-29 | 2022-05-27 | 三菱重工工程株式会社 | Method for fixing carbon dioxide |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180093136A (en) | 2018-08-20 |
| SG11201610558PA (en) | 2017-01-27 |
| WO2016006127A1 (en) | 2016-01-14 |
| JP6080810B2 (en) | 2017-02-15 |
| KR101958158B1 (en) | 2019-03-13 |
| JP2016020309A (en) | 2016-02-04 |
| HK1231368A1 (en) | 2017-12-22 |
| KR20170030583A (en) | 2017-03-17 |
| CN106535864B (en) | 2020-06-23 |
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