KR20170027721A - 마크로시클릭 광범위 항생제 - Google Patents

마크로시클릭 광범위 항생제 Download PDF

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KR20170027721A
KR20170027721A KR1020167035448A KR20167035448A KR20170027721A KR 20170027721 A KR20170027721 A KR 20170027721A KR 1020167035448 A KR1020167035448 A KR 1020167035448A KR 20167035448 A KR20167035448 A KR 20167035448A KR 20170027721 A KR20170027721 A KR 20170027721A
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alkyl
formula
optionally substituted
independently
compound
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Korean (ko)
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터커 쿠란 로버츠
피터 앤드류 스미스
로버트 아이 히구치
프라수나 파라셀리
필립 베르게론
마이클 에프 티 쾰러
희영 후
제이콥 브래들리 슈워즈
쿠옹 리
제임스 크로포드
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알큐엑스 파마슈티컬스, 인크.
제넨테크, 인크.
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KR1020167035448A 2014-05-20 2015-05-19 마크로시클릭 광범위 항생제 Withdrawn KR20170027721A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462000980P 2014-05-20 2014-05-20
US62/000,980 2014-05-20
US201562142404P 2015-04-02 2015-04-02
US62/142,404 2015-04-02
PCT/US2015/031631 WO2015179441A2 (en) 2014-05-20 2015-05-19 Macrocyclic broad spectrum antibiotics

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US (1) US10392422B2 (https=)
EP (1) EP3145944B1 (https=)
JP (2) JP6823588B2 (https=)
KR (1) KR20170027721A (https=)
CN (1) CN106661084B (https=)
BR (1) BR112016027232A2 (https=)
CA (1) CA2949681A1 (https=)
MX (1) MX2016015218A (https=)
RU (1) RU2016146581A (https=)
WO (1) WO2015179441A2 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
BR112016027232A2 (pt) 2014-05-20 2018-06-26 Genentech Inc antibióticos macrocíclicos de amplo espectro
US11072635B2 (en) 2015-11-20 2021-07-27 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
TWI725075B (zh) * 2015-11-20 2021-04-21 美商Ｒｑｘ製藥公司 巨環廣效抗生素
WO2017122697A1 (ja) * 2016-01-13 2017-07-20 Jsr株式会社 感放射線性樹脂組成物、レジストパターン形成方法、酸拡散制御剤及び化合物
WO2017156071A1 (en) 2016-03-09 2017-09-14 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
AU2017229591B2 (en) * 2016-03-09 2021-08-19 Blade Therapeutics Pty Ltd Calpain modulators and methods of production and use thereof
EP3481835A4 (en) 2016-07-05 2020-02-26 Blade Therapeutics, Inc. CALPAIN MODULATORS AND THERAPEUTIC USE THEREOF
BR112019006110A2 (pt) 2016-09-28 2019-09-10 Blade Therapeutics Inc moduladores de calpaína e usos terapêuticos dos mesmos
EP3330260A1 (en) 2016-12-01 2018-06-06 Enantia, S.L. Process for the preparation of an intermediate for the synthesis of i.a. carfilzomib
UA126027C2 (uk) * 2017-02-15 2022-08-03 АрКьюЕкс ФАРМАСЬЮТІКЛС, ІНК. Макроциклічні антибіотики широкого спектра
JP7086987B2 (ja) 2017-03-21 2022-06-20 ザ スクリプス リサーチ インスティテュート 銅およびニッケル触媒による脱炭酸ホウ素化反応
CN106966947B (zh) * 2017-03-30 2019-09-03 河北医科大学 一种维格列汀的制备方法
KR20240109280A (ko) * 2017-12-15 2024-07-10 메르크 파텐트 게엠베하 유기 전계 발광 디바이스용 치환된 방향족 아민
CN108806787B (zh) * 2018-07-06 2022-04-05 上海长海医院 面向临床手术的医用耗材智能监控系统
CN109355404B (zh) * 2018-08-30 2022-03-29 华南理工大学 基于聚合酶螺旋反应恒温检测单增李斯特菌的引物、试剂盒及检测方法
US12062453B2 (en) * 2018-09-19 2024-08-13 Georgia Tech Research Corporation Self-titrating bacterial protease-activated prodrug
ES2961566T3 (es) * 2019-05-28 2024-03-12 Hoffmann La Roche Antibióticos macrocíclicos de amplio espectro
CN118063337B (zh) * 2024-02-19 2025-01-28 绵阳师范学院 一种(s)-3-氨基-2-戊酮盐酸盐的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3128280A (en) 1959-10-23 1964-04-07 Searle & Co 1-(alkoxylated/halogenated phenyl)-3-pyridylmethylureas
US5204328A (en) 1990-06-26 1993-04-20 Merck & Co., Inc. Peptides having atrial natriuretic factor activity
EP0895999A1 (en) 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
GB9902399D0 (en) 1999-02-03 1999-03-24 Smithkline Beecham Plc Compounds
US6660832B1 (en) 1999-08-20 2003-12-09 Isis Pharmaceuticals, Inc. Macrocyclic compounds and preparation methods thereof
US6951840B2 (en) * 2001-08-31 2005-10-04 Eli Lilly And Company Lipoglycopeptide antibiotics
DE10226921A1 (de) 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
AU2004252174A1 (en) 2003-06-26 2005-01-06 Migenix Inc. Compositions of lipopeptide antibiotic derivatives and methods of use thereof
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014247A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
AU2011223790A1 (en) 2010-03-01 2012-08-30 Myrexis, Inc. Compounds and therapeutic uses thereof
MX2012010381A (es) 2010-03-09 2012-11-23 Merck Canada Inc Lipoglicopeptidos en puente que potencian la actividad de antibacterianos de beta-lactama.
US20130130985A1 (en) 2010-04-01 2013-05-23 Paul Alewood Oxytocin peptide analogues
US9187524B2 (en) 2010-09-15 2015-11-17 The Scripps Research Institute Broad spectrum antibiotic arylomycin analogs
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
TWI642684B (zh) 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
KR20140140580A (ko) * 2012-03-14 2014-12-09 더 스크립스 리서치 인스티튜트 광범위 항생제 아릴로마이신 유사체
CN103788176A (zh) 2012-10-31 2014-05-14 上海来益生物药物研究开发中心有限责任公司 一种arylomycin类化合物及其制备方法和应用
EA201590871A1 (ru) * 2012-11-21 2015-11-30 АрКьюЭкс ФАРМАСЪЮТИКЛС, ИНК. Макроциклические антибиотики широкого спектра действия
BR112016027232A2 (pt) 2014-05-20 2018-06-26 Genentech Inc antibióticos macrocíclicos de amplo espectro
ITUB20154591A1 (it) 2015-10-12 2017-04-12 Crestoptics S R L Apparato di microscopia confocale e relativo procedimento di acquisizione ed elaborazione di immagini
TWI725075B (zh) 2015-11-20 2021-04-21 美商Ｒｑｘ製藥公司 巨環廣效抗生素
US11072635B2 (en) 2015-11-20 2021-07-27 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics

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CN106661084A (zh) 2017-05-10
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RU2016146581A (ru) 2018-06-21
EP3145944A4 (en) 2018-01-03
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JP2021073210A (ja) 2021-05-13
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