KR20170018084A - Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법 - Google Patents

Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법 Download PDF

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Publication number
KR20170018084A
KR20170018084A KR1020177002960A KR20177002960A KR20170018084A KR 20170018084 A KR20170018084 A KR 20170018084A KR 1020177002960 A KR1020177002960 A KR 1020177002960A KR 20177002960 A KR20177002960 A KR 20177002960A KR 20170018084 A KR20170018084 A KR 20170018084A
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mmol
aryl
halogen
alkyl
alkoxy
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Korean (ko)
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댄 테오도레스쿠
마이클 벰페
데이비드 로스
챠오 얀
필립 레이건
Original Assignee
더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트
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Publication of KR20170018084A publication Critical patent/KR20170018084A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020177002960A 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법 Ceased KR20170018084A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462022946P 2014-07-10 2014-07-10
US62/022,946 2014-07-10
PCT/US2015/040021 WO2016007905A1 (en) 2014-07-10 2015-07-10 Anti-cancer compounds target ral gtpases and methods of using the same

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KR1020197005669A Division KR102093848B1 (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법

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KR20170018084A true KR20170018084A (ko) 2017-02-15

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KR1020177002960A Ceased KR20170018084A (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법
KR1020207008228A Ceased KR20200034824A (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법
KR1020197005669A Active KR102093848B1 (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법

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KR1020207008228A Ceased KR20200034824A (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법
KR1020197005669A Active KR102093848B1 (ko) 2014-07-10 2015-07-10 Ral gtpases를 타겟으로 하는 항암용 화합물 및 이의 사용방법

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US (4) US10202397B2 (enExample)
EP (2) EP3686202A1 (enExample)
JP (2) JP6672255B2 (enExample)
KR (3) KR20170018084A (enExample)
CN (1) CN106604731B (enExample)
AU (2) AU2015287567A1 (enExample)
CA (1) CA2954560C (enExample)
IL (1) IL249959A0 (enExample)
WO (1) WO2016007905A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016007905A1 (en) 2014-07-10 2016-01-14 The Regents Of The University Of Colorado, A Body Corporate Anti-cancer compounds target ral gtpases and methods of using the same
US10646475B2 (en) 2015-03-10 2020-05-12 The Trustees Of Princeton University SHMT inhibitors
US10077273B2 (en) 2016-09-14 2018-09-18 The Trustees Of Princeton University SHMT inhibitors
CN109305972B (zh) * 2018-09-27 2021-07-09 广州医科大学 一种二氢吡喃并吡唑类化合物及其制备方法和应用
EP3766544A1 (en) * 2019-07-18 2021-01-20 Centre Hospitalier Regional Universitaire de Lille Novel pyrazolone derivatives as pd-1/pd-l1 interaction inhibitors
CA3199138A1 (en) * 2020-11-18 2022-05-27 Texas Tech University System Therapies for cancer using small molecules that bind to and inhibit ral interacting proteins
CN114765064A (zh) * 2021-01-14 2022-07-19 南京天顶星医药科技有限公司 一种靶向RalA-GDP蛋白的药物的虚拟筛选方法
AU2022272475A1 (en) 2021-05-10 2023-10-05 Novalum S.a. Cathode current collector bar of an aluminium production cell
CN114632147B (zh) * 2021-11-09 2024-04-30 南京大学 人类受试者心肌病的治疗

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US5750550A (en) 1995-09-15 1998-05-12 Sanofi 2-(pyrazol-5-yl-oxymethyl)-1,2-benzisothiazol-3 (2H)-One 1, 1-dioxides and compositions and method of use thereof
JPH10279480A (ja) 1997-04-07 1998-10-20 Mitsubishi Chem Corp 皮膚組織障害の予防・治療剤
US6143471A (en) 1998-03-10 2000-11-07 Mitsubishi Paper Mills Limited Positive type photosensitive composition
WO2000040749A2 (en) 1999-01-06 2000-07-13 Genenews Inc. Method for the detection of gene transcripts in blood and uses thereof
WO2005020784A2 (en) * 2003-05-23 2005-03-10 Mount Sinai School Of Medicine Of New York University Surrogate cell gene expression signatures for evaluating the physical state of a subject
CA2533803A1 (en) * 2003-07-29 2005-02-10 Bristol-Myers Squibb Company Biomarkers of cyclin-dependent kinase modulation
KR20080015123A (ko) 2005-05-25 2008-02-18 다나베 미츠비시 세이야꾸 가부시키가이샤 피라졸론 유도체를 포함하는 의약
US7826982B2 (en) 2005-07-29 2010-11-02 Children's Hospital Medical Center Method of identifying inhibitors using a 3-D structure of RAC-1 GTPASE
KR20080040032A (ko) 2005-09-02 2008-05-07 티보텍 파마슈티칼즈 리미티드 Ｈｃｖ 저해제로서의 벤조디아제핀
EP1957474A4 (en) 2005-11-04 2011-08-24 Harvard College SYNTHESIS OF FTSZ HEMMERN
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WO2011010715A1 (ja) * 2009-07-24 2011-01-27 国立大学法人 東京大学 Ｐr－Ｓｅｔ７阻害剤
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WO2016007905A1 (en) * 2014-07-10 2016-01-14 The Regents Of The University Of Colorado, A Body Corporate Anti-cancer compounds target ral gtpases and methods of using the same
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AU2015287567A1 (en) 2017-02-16
JP2017520588A (ja) 2017-07-27
JP6672255B2 (ja) 2020-03-25
JP7102012B2 (ja) 2022-07-19
CN106604731A (zh) 2017-04-26
US20170204112A1 (en) 2017-07-20
WO2016007905A1 (en) 2016-01-14
US11472812B2 (en) 2022-10-18
EP3686202A1 (en) 2020-07-29
EP3166609B1 (en) 2020-03-11
CA2954560C (en) 2021-12-28
USRE48557E1 (en) 2021-05-18
KR20200034824A (ko) 2020-03-31
EP3166609A4 (en) 2017-12-27
AU2020277293A1 (en) 2021-01-07
EP3166609A1 (en) 2017-05-17
IL249959A0 (en) 2017-03-30
CA2954560A1 (en) 2016-01-14
JP2020105195A (ja) 2020-07-09
KR102093848B1 (ko) 2020-03-30
CN106604731B (zh) 2021-05-18
AU2020277293B2 (en) 2021-10-21
US10676480B2 (en) 2020-06-09
KR20190022929A (ko) 2019-03-06
US10202397B2 (en) 2019-02-12
US20190135824A1 (en) 2019-05-09
US20200255442A1 (en) 2020-08-13

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